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Publication numberUSRE35390 E
Publication typeGrant
Application numberUS 08/393,156
Publication dateDec 3, 1996
Filing dateFeb 17, 1995
Priority dateNov 17, 1989
Fee statusPaid
Publication number08393156, 393156, US RE35390 E, US RE35390E, US-E-RE35390, USRE35390 E, USRE35390E
InventorsStewart G. Smith
Original AssigneeSmith; Stewart G.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Pressure relieving device and process for implanting
US RE35390 E
Abstract
This invention involves a porous device for implantation in the scleral tissue of the eye to relieve the intraocular pressure of glaucoma and a method for surgically implanting the device.
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Claims(7)
What is claimed is:
1. A device for relieving intraocular pressure comprises a body portion .Iadd.and wall portions in the form of a hexahedron; at least the body portion .Iaddend.composed of a biocompatible porous material; said device adapted to be implanted within the scleral tissue of the eye with at least one edge of the device at an opening of, with no substantial extension into, the anterior chamber and adjacent to the area where the sclera makes the transition into clear cornea of the eye; the pores of the body portion are of such size and quantity as to permit drainage of fluid from the anterior chamber to the scleral tissue without collapse of the anterior chamber.
2. A device as in claim 1 wherein .[.one face of the hexahedron is.]. .Iadd.said body portion has a first surface, said first surface of said body portion being .Iaddend.sloped to overlie the opening into the anterior chamber to direct fluid from the anterior chamber into the body portion of the device.
3. A device as in claim 1 wherein .[.at least one edge of one wall portion of the device.]. at least one edge of .[.one wall portion.]. .Iadd.the top surface .Iaddend.of the device is extended for anchoring the device in position.
4. A device as in claim 1 wherein the .Iadd.three .Iaddend.edges of .[.three wall portions of.]. the .Iadd.top surface of the .Iaddend.device, other than .[.an.]. .Iadd.the .Iaddend.edge at the opening of the anterior chamber, are extended for anchoring the device in position.
5. A device as in claim 1 wherein a thin flange extends from four sides of the base of the device, the flange at the posterior side of the device being raised and held in position by extensions of the vertical walls of said device .[.four sides of the base of device, the flange at the posterior side of the device being raised and held in position by extensions of the vertical walls of said device..].
6. A method for reducing intraocular pressure comprising the steps of:
creating a scleral flap by making an incision in the sclera substantially adjacent to the limbus of the eye;
excising a block of sclera by making a second incision into the sclera underneath the previously produced scleral flap but extending into the cornea and entering the anterior chamber at substantially the area where sclera becomes cornea to provide a pocket in the sclera and a shelf in the cornea .[.and to provide a window providing direct fluid contact with the anterior chamber of the eye.].;
.[.providing a device for relieving intraocular pressure, said device comprising a body portion composed of a biocompatible porous material, said body portion comprising a first end portion and a second end portion, said body portion defining pores therethrough, said pores being of such size and quantity as to permit drainage of fluid from the anterior chamber to the scleral tissue without collapse of the anterior chamber.].; and
placing .[.said device for relieving intraocular pressure.]. .Iadd.the hexahedrally shaped device of claim 1 .Iaddend.in said pocket of the sclera .[.whereby said first end.]. .Iadd.with the anterior portion of said device .[.is.]. positioned in said shelf of the cornea .[.such that said first end portion is adjacent said window and is in direct fluid contact with the anterior chamber without extending substantially into the anterior chamber and whereby said second end portion is.]. .Iadd.with the remaining portions of the device .Iaddend.positioned within the sclera. .Iadd.
7. A device for relieving intraocular pressure comprising a body portion constructed of a biocompatible material having flow passages therein; said flow passages selected from the group consisting of pores, openings, channels and spaces between fibers in a meshwork of fibers; said device having a substantially uniform cross-section adapted to be fitted within the scleral tissue of the eye at an area adjacent an opening of, with no substantial extension into, the anterior chamber of the eye at a first position adjacent to the area of the eye where the sclera makes the transition into clear cornea of the eye; and extending to a second position within the scleral tissue of the eye, the distance between said first and second positions defining the length of the body portion through which fluid can flow, said length being approximately six (6) millimeters; said flow passages being of such size and quantity as to permit drainage of fluid from the anterior chamber to the scleral tissue without collapse of the anterior chamber..Iaddend..Iadd.8. A method for reducing intraocular pressure within the anterior chamber of an eye, said method comprising the following steps
a. creating a scleral flap by making an incision in the sclera of the eye substantially adjacent to the limbus of the eye;
b. excising a block of scleral tissue by making a second incision into the sclera underneath the previously produced scleral flap but extending into the cornea and entering the anterior chamber at substantially the area where sclera becomes cornea to provide a pocket in the sclera and a shelf in the cornea, c. placing a device for relieving intraocular pressure, said device comprising a body portion constructed of a biocompatible material; and having flow passages therein; said device having a first end portion and a second end portion with said flow passages therebetween; and
d. the device being placed in said pocket of the sclera with said first end portion of said device positioned in said shelf of the cornea whereby said first end portion of said body portion is in direct fluid contact with the anterior chamber of the eye without substantial extension into the anterior chamber of the eye and with the second end portion of said device positioned within the sclera of the eye to permit drainage of fluid from the anterior chamber into the scleral tissue without collapse of the anterior chamber..Iaddend.
Description

.Iadd.This application is a continuation of Serial No. 08/170,664, filed Dec. 16, 1993, now abandoned, which is a continuation of 07/925,726 filed Aug. 4, 1992, now abandoned, which is a reissue of 07/437,840, filed Nov. 17, 1989, now U.S. Pat. No. 4,946,436..Iaddend.

FIELD OF INVENTION

This invention relates to the drainage of aqueous humour from eyes in the course of relieving eye disorders. Specifically, the invention relates to an implant which, when permanently affixed to or implanted in a specific area of the eye, will provide such drainage efficiently, for longer periods than heretofore accomplished, and, in short, will provide relief and prevent (or at least postpone) the adverse ultimate effects of glaucoma.

BACKGROUND OF THE INVENTION

The eyeball is composed of three basic layers: (1) the sclera. (2) the middle layer and (3) the retina.

The sclera is the outer layer of the eyeball. It consists of tough, white tissue that serves as the supporting framework of the eye. At the front of the eye, the sclera is continuous with the clear, transparent cornea through which light enters the eye. Behind the cornea is a small space, the anterior chamber, which contains a clear watery fluid called the aqueous humour.

The middle layer is composed of three parts: (1) the choroid. (2) the ciliary muscle, and (3) the iris. The choroid lies behind and to the sides of the eyeball making up about 80% of the middle layer. It contains most of the blood vessels that nourish the eye.

Toward the front of the eyeball, the choroid becomes the ciliary muscle. This muscle is connected by fibers to the lens, keeping the lens in place and controlling its shape.

At the very front, the middle layer becomes the iris, a thin curtain of tissue in front of the lens. A round opening in the iris, whose size is controlled by muscles in the iris, is called the pupil.

In simple terms, the cornea refracts light through the anterior chamber and then through the pupil, the entrance aperture of the eye to the lens. The lens serves to focus the refracted light through the vitreous chamber containing the vitreous humour onto the retina, the rear surface of the eye.

Normally the fluid within the eye, the aqueous humour, is produced by the-ciliary body and migrates through the pupil into the anterior chamber, the small space behind the cornea. From this chamber, the liquid migrates through the trabecular meshwork and into the aqueous veins which form fluid collection channels beneath the conjuctiva, the latter covering the front of the eyeball except for the cornea.

When the aqueous, migration, described above, is insufficient to relieve the build-up of intra-ocular pressure, glaucoma results. This pressure build-up is usually due to one or more obstructions in the trabecular meshwork. Unless controlled, the high pressures associated with glaucoma ultimately leads to permanent damage of the optic nerve, the nerve formed from the sensitive fibers of the retina.

The object of the present invention is to provide a device that can be implanted permanently, simply and effectively to permit substantially normal migration of fluid out of the anterior chamber of the eye and, thus, avoid the abnormal build-up of intra-ocular pressure. Another object is to provide the implant in a manner that will also avoid excessive migration of fluid that would lead to collapse of the anterior chamber with its accompanying complications.

PRIOR ART

U.S. Pat. No. 4,457,757, issued Jul. 3, 1984 to A. C. B. Molteno, involves the use of at least two ridged bodies anchored to the sclera with two tubular extensions, one communicating through the sclera to the anterior chamber to drain the aqueous humour out of the eyeball.

U.S. Pat. No. 4,750,901, issued Jun. 14, 1988, to A. C. B. Molteno, recognized a problem that arose with his earlier device (as described in U.S. Pat. No. 4,457,757). In the first few days after insertion of the earlier device, the pressure within the eye tends to fall to an unacceptably low level "which may result in surgical complications which damage sight". This fall in pressure is due to excessive absorption of the aqueous humour by the patient's Tenon capsule, a smooth layer of tissue that covers the scleral plate when it is sutured to the eye. This later patent discloses the use of a subsidiary ridge in the upper surface the scleral plate that provides, with a portion of the Tenon's tissue, a small cavity where aqueous humour is drained initially and, thus, the aqueous humour can only be partially absorbed by the small area of Tenon's tissue exposed.

U.S. Pat. No. 4,634,418, issued Jan. 6, 1987, to P. S. Binder, involves the implantation of a seton constructed of a hydrogel in the anterior chamber of the eye to alleviate intra-ocular pressure. Once implanted, the seton acts as a wick to transfer aqueous humour from the anterior chamber to the space under the conjunctiva without allowing bacteria to ingress into the eye. Implantation is made after the removal of a rectangular-sized piece of cornea, Schalbe's line and a portion of the trabecular meshwork.

U.S. Pat. No. 4,722,724, issued Feb. 2, 1988, to S. Schocket, involves the use of an implant that includes two connected tubes or a tube connected to a band. One tube is located in the anterior chamber and the other tube or band is located around the orbit of the eye. To prevent hypotony, a destructible value is located at the end of the tube inserted with the interior chamber to control the pressure of the aqueous humour flowing from the chamber.

U.S. Pat. No. 4,787,885, issued Nov. 29, 1988 to P. S. Binder, is a continuation of an application that was a continuation-in-part of the application that resulted in U.S. Pat. No. 4,634,418. This patent, like its predecessor, also involves the removal of a rectangular-sized piece of cornea, Schwalbe's line and a portion of the trabecular meshwork to accomodate a seton; and the seton permits migration of the aqueous humour from the anterior chamber to the area beneath the conjunctiva (the external covering of the eye).

In both patents, the inventor achieves fluid flow to the exterior of the sclera into a space created beneath the conjunctiva and the accompanying Tenon's tissue that covers the scleral plate, i.e. outside the main body of the eye. Since these areas are particularly agressive in healing, the reduction in intra-ocular pressure is short-lived; the space created beneath the conjunctiva and the tenon tissue tends to collapse and prevent further migration of the fluid from the anterior chamber with the consequent pressure increase, characteristic of glaucoma.

The object of the present invention is to provide a means and method for treating the excessive intra-ocular pressure characteristic of glaucoma in a manner which will not be defeated by the subsequent healing process i.e. in a manner that will provide the patient with relief for several years. A further object is to help avoid other problems such as collapse of the anterior chamber, penetration of scar tissue over the trabecular meshwork, which tend to occur in the immediate post operative period with the conventional glaucoma surgery (trabeculotomy) disclosed in the prior art.

SUMMARY OF THE INVENTION

The invention involves an implant that is biocompatible with the tissue of the eye and allows fluid to migrate from the anterior chamber into the coarsely woven fibers of the sclera, thus by-passing the obstructed trabecular meshwork but, instead of leaving the body of the eye, exiting into the outer layer of the eyeball, the sclera. The normal pressure of fluid in the sclera serves to control the flow from the anterior chamber in a way that disastrous collapse of the chamber is prevented. Further, by not creating a space to accept fluid beneath the conjunctiva and the associated Tenon's tissue, the aggressive healing of these areas is not effective in recreating the excessive intra-ocular pressure in the anterior chamber.

Basically, this invention involves substituting a material that is composed of small pores of similar size or larger than a healthy trabecular meshwork in an area almost adjacent to the area of the troubled trabecular meshwork, i.e. close to where the sclera meets the cornea. In this manner, an area of relatively small pores within the implant, is placed within the relatively large pores of the sclera.

Specifically, the device for relieving intraocular pressure comprises a body portion and wall portions in substantially hexahedral form; at least the body portion is composed of a biocompatible porous hydrogel material. The device is adapted to be implanted within the scleral tissue of the eye with at least one edge of the device at an opening of, with no substantial extension into the anterior chamber adjacent to the area where the sclera makes the transition into the clear cornea of the eye. The pores of the body portion are of such size and quantity as to permit drainage of fluid from the anterior chamber to the scleral tissue without collapse of the anterior chamber. The wall portions have at least one extension on at least one wall portion for anchoring the device securely in position.

The implant is made from a hydrogel or other material which is biocompatible with the tissue of the eye. Such hydrogel material may have a water content ranging anywhere from about 30% to about 80%. Typically, such materials comprise silicones, acrylic polymers and/or fluorocarbon polymers or the like. The implant is shaped to retain its position once it is implanted within the eye and to provide sufficient surface area to accomodate the migration of the aqueou humour in a controlled manner, i.e. enough migration to reduce intra-ocular pressure but not enough to cause collapse of the chamber.

The invention will be more clearly understood by referring to the drawings and the description which follow.

THE DRAWINGS

FIG. 1 is a cross-sectional view of the eye showing one embodiment of the invention implanted therein;

FIG. 2 is a side view of that embodiment of the invention;

FIG. 3 is a front view of that embodiment;

FIG. 4 is a plan or top view of that emobodiment;

FIG. 5 is a side view of another emobodiment of the invention;

FIG. 6 is a front view of that other embodiment; and

FIG. 7 is a plan view of that other embodiment.

DETAILED DESCRIPTION OF THE INVENTION

In the first embodiment, the overall shape of the device 11 is a hexahedral structure having a substantially rectangular cross-section as shown in FIG. 1, approximately 6 mm in length, 3 mm in width, and 1/2 mm in depth. The device 11 is designed to be placed in a pocket made in the sclera 12 as seen in FIG. 1 in the following manner. An incision is made in the sclera, 2 mm from the limbus of the eye. A rectangular flap is raised into the clear cornea 13. The overall thickness of this flap is approximately 1/3 mm. Following the same incision technique, another flap of sclera 12 is raised underneath the previously made flap but extending into clear cornea 13. This block of sclera is then excised by entering the anterior chamber 14 at the anterior wound edge 15 (just as the sclera 12 makes the transition into clear cornea, 13). The aqueous fluid would then be able to enter this space through an opening; 16, 4 1/2 mm in length, 1 mm in width, and 1/2 mm in depth. (Since the cornea follows a curve, the tissue excised would be triangular when viewed from the side.)

The implant 11 is then placed in this pocket created in the sclera 12 with the anterior portion of the device anchored in the lamellar shelf 17 previously created in the clear cornea 13. It should be noted that by anchoring the device in the lamellar shelf rather than extending the device into the anterior chamber, contact with the endothelial cells 18 along the interior surface of the cornea is avoided. Such contact would result in the death of these cells and the loss of corneal function.

Small lamellar dissections (1 mm in size) are created in the posterior wall, medial wall and lateral wall of the sclera 12. Using the embodiment of the device containing flanges, the flanges 19 (or extensions integral with the device) are placed within these lamellar dissections. By sliding the device 11 anteriorly, it becomes firmly anchored in the previously prepared corneal lamellar shelf 17. If necessary, it can be further secured by suturing the device to assure maintenance of its position. The first scleral flap is then sutured back into position. The sclera 12 with the implant 11 in position would be of approximately the same thickness as before the procedure.

Fluid would then exit the anterior chamber 14 through the incision under the flap and to the implanted device 11. It would then enter the implant 11 which would allow it access to three vertical walls of sclera because of the porous nature of the interior 20 of the implant. The coarsely woven fibers of the vertically cut sclera 12 would then allow the fluid to exit into the tissue 21 of the sclera 12.

The other embodiment shown in FIGS. 5, 6 and 7 consists of a similar basic implant 11 having similar dimensions but with a thin flange 19 (1/8 mm) around the base of the implant on all four sides. The flange would project 1 mm from the sides that would be in contact with the sclera only and about 1/2 mm for the side which would project into a raised flange. This raised flange is attached by a 1 mm extension 22 of the vertical walls of the portion of the implant in contact with the sclera. This extension is approximately 1/8 mm thick. Attached perpendicularly to this extension is the flange 19. The point of attachment is at the mid section of the flange. The flange is 1/8 mm thick and 2 mm wide. The posterior section is 7 mm in length and the two sides are 2 1/2 mm in length.

This embodiment is implanted in a similar fashion to the previously described implant with the following modifications. 1. The initial scleral flap would be 1/2 mm. 2. A block of sclera would not be excised. 3. A lamellar dissection would be performed at the base of the flap for approximately 1 mm. 4. After the opening into the anterior chamber is created, the implant is placed into position sliding the posterior flange into the previously formed space from the lamellar dissection. The scleral flap is then placed back into its previous position and underneath the superior flange. This superior flange would overlie the incision into the sclera to create a flap of 1 mm on each side except for the furthermost anterior aspect (which would not be covered by Tenon's tissue since it does not insert as far anteriorly as the conjunctiva). The scleral flap is then sutured into position through the superior flange.

This embodiment would help prevent ingrowth of Tenon's tissue into the incision and would be firmly anchored into position. It also would allow access to vertically cut edges of sclera in the same manner as the previous embodiment.

A further modification of the device of the invention involves the particular method by which the fluid from the anterior chamber travels to the sclera. This modification would involve the use of a meshwork of fibers .Iadd.26 .Iaddend.to allow rapid flow of fluid through the spaces .Iadd.28 .Iaddend.between the fibers. The meshwork of fibers .Iadd.26 .Iaddend.being made of a biocompatible material would be flexible. The meshwork would allow fluid flow to the vertically cut edges of the implant and the sclera.

Another way to achieve porosity would be through a system of channels .Iadd.30 .Iaddend.through the implant. A variety of patterns could be cut so as to achieve high fluid flow through the implant to the vertically cut edges. For example, a fan shaped system .Iadd.32 .Iaddend.of drilled holes or a grid pattern of drilled holes from front to back or an interlocking pattern drilled from side to side, etc. could be used. The purpose and design are such that fluid could pass through, as described above, and the implant would resist collapse from the imposed pressure.

A typical operation for inserting the preferred embodiment of the invention follows: After retrobulbar anesthesia, the superior rectus muscle is placed on a four O silk bridal suture. Following this, a conjunctival flap is raised starting at the superior rectus and working forward to This is then reflected back to the cornea. Cautery is used to obtain hemostasis and to outline the location of the placement for the implant. A rectangular area, 5 mm by 3 mm, is outlined using a 64 Beaver blade. A small groove is made on the sclera side to half the depth of the sclera. This is grasped at one corner and the flap is dissected anteriorly until the rectangular flap is completely raised in the clear cornea. At this point a 75 blade is used to make a stab incision into the anterior chamber of the eye and a 1 by 4 mm section of the cornea and trabecular meshwork are excised en bloc.

Using a lamellar dissecting blade, attention is turned to the posterior aspect of the bed of the rectangular flap. Further dissection at the base is carried posteriorly for approximately 0.5 millimeter. The implant is then placed into position in this bed with the inferior posterior flap laid into the groove that has just been created on the posterior aspect of the bed. The anterior portion is in direct communication with the anterior chamber. The scleral flap is then laid over this implant and tucked in underneath the superior flanges that are present. If necessary, a portion of the scleral flap can be excised so that the sclera lays down smoothly over the implant. The implant is then sutured to the sclera on both sides with a 10-O nylon suture through the fixation holes in the superior flange. The conjunctival tissue is then sutured back together with a 6-O-plain gut running suture.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4037604 *Jan 5, 1976Jul 26, 1977Newkirk John BArtifical biological drainage device
US4457757 *Jul 20, 1981Jul 3, 1984Molteno Anthony C BDevice for draining aqueous humour
US4521210 *Dec 27, 1982Jun 4, 1985Wong Vernon GEye implant for relieving glaucoma, and device and method for use therewith
US4634418 *Apr 6, 1984Jan 6, 1987Binder Perry STreating uncontrolled glaucoma; a conduit for fluid migration; surgical implant
US4722724 *Jun 23, 1986Feb 2, 1988Stanley SchocketAnterior chamber tube shunt to an encircling band, and related surgical procedure
US4750901 *Mar 5, 1987Jun 14, 1988Molteno Anthony C BImplant for drainage of aqueous humour
US4787885 *Mar 6, 1987Nov 29, 1988Binder Perry SHydrogel seton
US4936825 *Apr 11, 1988Jun 26, 1990Ungerleider Bruce AMethod for reducing intraocular pressure caused by glaucoma
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US5752928 *Jul 14, 1997May 19, 1998Rdo Medical, Inc.Glaucoma pressure regulator
US6280468Apr 16, 1998Aug 28, 2001Ras Holding CorpScleral prosthesis for treatment of presbyopia and other eye disorders
US6299640Dec 27, 1999Oct 9, 2001R A S Holding CorpScleral prosthesis for treatment of presbyopia and other eye disorders
US6450984Apr 26, 2000Sep 17, 2002Gmp Vision Solutions, Inc.Shunt device and method for treating glaucoma
US6464724Apr 26, 2000Oct 15, 2002Gmp Vision Solutions, Inc.Stent device and method for treating glaucoma
US6524275Apr 26, 2000Feb 25, 2003Gmp Vision Solutions, Inc.Inflatable device and method for treating glaucoma
US6533768Apr 14, 2000Mar 18, 2003The Regents Of The University Of CaliforniaDevice for glaucoma treatment and methods thereof
US6595945Jan 9, 2001Jul 22, 2003J. David BrownGlaucoma treatment device and method
US6626858Sep 12, 2002Sep 30, 2003Gmp Vision Solutions, Inc.Shunt device and method for treating glaucoma
US6638239Apr 14, 2000Oct 28, 2003Glaukos CorporationApparatus and method for treating glaucoma
US6666841May 2, 2001Dec 23, 2003Glaukos CorporationBifurcatable trabecular shunt for glaucoma treatment
US6699210 *Apr 27, 1999Mar 2, 2004The Arizona Board Of RegentsGlaucoma shunt and a method of making and surgically implanting the same
US6736791Nov 1, 2000May 18, 2004Glaukos CorporationGlaucoma treatment device
US6780164Mar 21, 2003Aug 24, 2004Glaukos CorporationL-shaped implant with bi-directional flow
US6783544Oct 11, 2002Aug 31, 2004Gmp Vision Solutions, Inc.Stent device and method for treating glaucoma
US6827699May 27, 2003Dec 7, 2004Gmp Vision Solutions, Inc.Shunt device and method for treating glaucoma
US6827700May 27, 2003Dec 7, 2004Gmp Vision Solutions, Inc.Shunt device and method for treating glaucoma
US6881198Jun 16, 2003Apr 19, 2005J. David BrownGlaucoma treatment device and method
US6955656Dec 4, 2002Oct 18, 2005Glaukos CorporationApparatus and method for treating glaucoma
US6981958Jul 24, 2003Jan 3, 2006Glaukos CorporationImplant with pressure sensor for glaucoma treatment
US6991650May 22, 2001Jan 31, 2006Refocus Ocular, Inc.Scleral expansion device having duck bill
US7008396Aug 30, 2000Mar 7, 2006Restorvision, Inc.Ophthalmic device and method of manufacture and use
US7037335Nov 19, 2002May 2, 2006Eagle Vision, Inc.Bulbous scleral implants for the treatment of eye disorders such as presbyopia and glaucoma
US7094225May 3, 2002Aug 22, 2006Glaukos CorporationMedical device and methods of use of glaucoma treatment
US7135009Apr 8, 2002Nov 14, 2006Glaukos CorporationGlaucoma stent and methods thereof for glaucoma treatment
US7160264Dec 16, 2003Jan 9, 2007Medtronic-Xomed, Inc.Article and method for ocular aqueous drainage
US7163543Jun 7, 2002Jan 16, 2007Glaukos CorporationCombined treatment for cataract and glaucoma treatment
US7186232Mar 7, 2003Mar 6, 2007Glaukoa CorporationFluid infusion methods for glaucoma treatment
US7273475Oct 21, 2005Sep 25, 2007Glaukos CorporationMedical device and methods of use for glaucoma treatment
US7297130Mar 21, 2003Nov 20, 2007Glaukos CorporationImplant with anchor
US7331984Aug 28, 2002Feb 19, 2008Glaukos CorporationGlaucoma stent for treating glaucoma and methods of use
US7431710Mar 18, 2005Oct 7, 2008Glaukos CorporationOcular implants with anchors and methods thereof
US7488303Sep 22, 2003Feb 10, 2009Glaukos CorporationOcular implant with anchor and multiple openings
US7563241Nov 13, 2006Jul 21, 2009Glaukos CorporationImplant and methods thereof for treatment of ocular disorders
US7678065Sep 24, 2004Mar 16, 2010Glaukos CorporationImplant with intraocular pressure sensor for glaucoma treatment
US7708711Nov 12, 2003May 4, 2010Glaukos CorporationOcular implant with therapeutic agents and methods thereof
US7850637Nov 12, 2004Dec 14, 2010Glaukos CorporationShunt device and method for treating glaucoma
US7857782Feb 5, 2009Dec 28, 2010Glaukos CorporationOcular implant delivery system and method thereof
US7867186Aug 5, 2003Jan 11, 2011Glaukos CorporationDevices and methods for treatment of ocular disorders
US7867205May 6, 2005Jan 11, 2011Glaukos CorporationMethod of delivering an implant for treating an ocular disorder
US7879001Aug 8, 2007Feb 1, 2011Glaukos CorporationDevices and methods for treatment of ocular disorders
US7879079Jun 19, 2006Feb 1, 2011Glaukos CorporationImplant delivery system and methods thereof for treating ocular disorders
US7927372Jul 31, 2008Apr 19, 2011Refocus Group, Inc.Scleral prosthesis having crossbars for treating presbyopia and other eye disorders
US7951155Jan 16, 2007May 31, 2011Glaukos CorporationCombined treatment for cataract and glaucoma treatment
US8007459Dec 18, 2008Aug 30, 2011Glaukos CorporationOcular implant with anchoring mechanism and multiple outlets
US8062244Feb 5, 2009Nov 22, 2011Glaukos CorporationSelf-trephining implant and methods thereof for treatment of ocular disorders
US8075511Apr 28, 2008Dec 13, 2011Glaukos CorporationSystem for treating ocular disorders and methods thereof
US8118768Oct 6, 2008Feb 21, 2012Dose Medical CorporationDrug eluting ocular implant with anchor and methods thereof
US8142364Jan 4, 2010Mar 27, 2012Dose Medical CorporationMethod of monitoring intraocular pressure and treating an ocular disorder
US8152752Nov 12, 2004Apr 10, 2012Glaukos CorporationShunt device and method for treating glaucoma
US8273050Jul 12, 2004Sep 25, 2012Glaukos CorporationOcular implant with anchor and therapeutic agent
US8333742May 7, 2009Dec 18, 2012Glaukos CorporationMethod of delivering an implant for treating an ocular disorder
US8337445Sep 25, 2007Dec 25, 2012Glaukos CorporationOcular implant with double anchor mechanism
US8337550Dec 6, 2010Dec 25, 2012Refocus Ocular, Inc.Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8348877May 3, 2010Jan 8, 2013Dose Medical CorporationOcular implant with therapeutic agents and methods thereof
US8388568May 7, 2009Mar 5, 2013Glaukos CorporationShunt device and method for treating ocular disorders
US8409277Jul 11, 2007Apr 2, 2013Refocus Ocular, Inc.Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8506515Nov 9, 2007Aug 13, 2013Glaukos CorporationUveoscleral shunt and methods for implanting same
US8579846Nov 21, 2011Nov 12, 2013Glaukos CorporationOcular implant systems
US8617094Jan 12, 2006Dec 31, 2013Glaukos CorporationFluid infusion methods for glaucoma treatment
US8632489Dec 22, 2011Jan 21, 2014A. Mateen AhmedImplantable medical assembly and methods
US8771217Dec 13, 2010Jul 8, 2014Glaukos CorporationShunt device and method for treating ocular disorders
US8801648Feb 5, 2009Aug 12, 2014Glaukos CorporationOcular implant with anchor and methods thereof
US8801649Oct 5, 2010Aug 12, 2014Transcend Medical, Inc.Glaucoma treatment device
US8808219Feb 5, 2009Aug 19, 2014Glaukos CorporationImplant delivery device and methods thereof for treatment of ocular disorders
US8808220Oct 14, 2010Aug 19, 2014Transcend Medical, Inc.Ocular pressure regulation
US8814819Dec 16, 2010Aug 26, 2014Transcend Medical, Inc.Glaucoma treatment device
US8814820Sep 20, 2012Aug 26, 2014Glaukos CorporationOcular implant with therapeutic agent and methods thereof
EP2078516A2Mar 8, 2001Jul 15, 2009Glaukos CorporationImplant for treating ocular disorders
EP2260803A2Mar 8, 2001Dec 15, 2010Glaukos CorporationOcular implant system for treating glaucoma
Classifications
U.S. Classification604/8
International ClassificationA61F9/007
Cooperative ClassificationA61F9/00781
European ClassificationA61F9/007V
Legal Events
DateCodeEventDescription
Apr 3, 2002SULPSurcharge for late payment
Year of fee payment: 11
Apr 3, 2002FPAYFee payment
Year of fee payment: 12
Jun 4, 1998FPAYFee payment
Year of fee payment: 8
Jun 4, 1998SULPSurcharge for late payment