|Publication number||USRE37479 E1|
|Application number||US 09/227,163|
|Publication date||Dec 18, 2001|
|Filing date||Jan 7, 1999|
|Priority date||Mar 15, 1995|
|Also published as||CA2214509A1, CA2214509C, DE69625339D1, DE69625339T2, EP0814732A1, EP0814732A4, EP0814732B1, US5591235, WO1996028118A1|
|Publication number||09227163, 227163, US RE37479 E1, US RE37479E1, US-E1-RE37479, USRE37479 E1, USRE37479E1|
|Inventors||Stephen D. Kuslich|
|Original Assignee||Spineology, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (34), Referenced by (83), Classifications (72), Legal Events (5)|
|External Links: USPTO, USPTO Assignment, Espacenet|
1. Field of the Invention
This invention relates to a device for fixing adjacent vertebrae to each other using a rod and unique hollow screws.
2. Description of the Related Art
Fixation (or fusion) of vertebral columns with bone material or rods and plates is a common, long practiced surgical method for treating a variety of conditions. Many of the existing procedures involve components that protrude outwardly that may contact and damage a body part, such as the aorta, the vena cava, the sympathetic nerves, the intestine and the ureter. Also, many constructions involve components that may loosen and cause undesirable problems. A Dunn device was on the market until pulled by the U.S. Food & Drug Administration because of problems with delayed rupture of the aorta secondary to the device being so bulky as to contact the aorta, erode its surface and lead to fatal hemorrhage in several cases.
U.S. Pat. No. 5,152,303 issued to Allen on Oct. 6, 1992 relates to an anterolateral spinal fixation system including a cannulated screw threaded into a vertebra and a rod attached to the screw. The process involves threading the cannulated screw into a pilot hole drilled into the vertebral body portion and fastening a rod at its lower and upper ends to the vertebral body by the cannulated screws. (Col. 3, lines 62-64; Col. 4, lines 5-8).
U.S. Pat. No. 4,059,115 issued to Jamashev et al. on Nov. 22, 1977 relates to a surgical instrument for operation of anterior fenestrated spondylodesis in vertebral osteochondrosis. The instrument includes a hollow cylindrical cutter with a cutting edge, and a handle. By rotation of the handle accompanied with slight pressure the cutter is worked into the bodies of the adjacent vertebras (abstract, Col. 6, lines 56-58).
U.S. Pat. No. 5,015,247 issued to Michelson on May 14, 1991 relates to a method of performing internal stabilization of a spine. The method involves seating a drill sleeve into the two vertebrae and drilling the vertebrae with the drill installed through the drill sleeve. Bagby U.S. Pat. No. 4,501,269 is mentioned. (Col. 6, lines 27-30, Col. 7, line 68, Col. 9, lines 22-25, 39).
Current devices have substantial deficiencies when osteoporotic bone is encountered. The soft, decalcified bone in such patients has poor pull-out strength for screws. Bone screws are known to have very little holding power in osteoporotic bone and loosen readily, severely limiting the holding power and fixation ability of current devices.
Some devices have designs that include hollow screws or screws with transversely drilled holes, presumably to improve holding power and allow bone to grow therethrough. These devices are all relatively small screws which are not capable of large surface area fixation.
The art described in this section is not intended to constitute an admission that any patent, publication or other information referred to herein is “prior art” with respect to this invention, unless specifically designated as such. In addition, this section should not be construed to mean that a search has been made or that no other pertinent information as defined in 37 C.F.R. §1.56(a) exists.
The invention provides a method and device for fixing two or more vertebrae. The process is elegantly simple and solves many of the problems attendant with previous devices.
Each vertebra to be joined is prepared by forming a partial annular cut, as by a hole saw, preferably leaving the core plug of bone in place. A hollow screw is threaded into the annular ring recess thus formed. A channel is cut in the vertebral bone between each of the screws to accommodate a rod that is placed over each screw. A locking cap over each screw secures the rod to the screws and thereby fixes the spine as desired.
The method and device provide many advantages. The hollow screws are exceptionally strong, having greater holding surface area than conventional solid screws. The rod is held in the screw between two widely spaced slots. The rod is also held firmly by a third point by a dimple on the locking cap. The rod is secured to the screws by at least three points of fixation over a much greater distance than traditional systems. This provides a linkage which is significantly greater in terms of mechanical stability over the prior art.
Holes in the side walls of the hollow screws allow for bone ingrowth to further strengthen the connection. Since the bone plug is not removed, the screw's wall is very thin, bone can grow through the screw rapidly, thus securely fusing the screw to the vertebra and provides a better anchor to the vertebral bone. Additionally, as the bone grows through the holes in the screw, the bond becomes stronger with time. Prior art devices use screws that may slowly become less secure with age and the inevitable micromotion that occurs between the screw and the vertebral bone.
By varying the cross-section geometric structure and diameter of the rod, various degrees of stiffness may be imparted. Also, by varying the geometric cross-section structure of the rod, stiffness may be imparted selectively in the appropriate plane of motion. For instance, if increased flexion-extension stability is desired, the rod can be oriented in the flexion-extension plane and elongated such that it will provide greater stiffness in flexion-extension than in lateral bending. Such a feature will allow the surgeon to define the plane of stiffness necessary to match the pathology encountered.
The rods within the cut channels avoid the cantilever effect of prior art devices where the load is carried far from the center of the spine. Thus, the rod acts more like an intramedullary rod in the vertebrae. This is far preferable in that a rod nearer the center of the axis of rotation does not have the cantilever effect of prior art systems. This also presents no protrusions that may abut against vital body components.
The process is very simple, requiring only the drilling of a single hole saw cut in each vertebra, formation of channels therebetween and installation of the hollow screws, placement of the rod and securement with the locking caps.
A detailed description of the invention is hereafter described with specific reference being made to the drawings in which:
FIG. 1 is a perspective view of the device of the invention securing vertebrae together;
FIG. 2 is an exploded view of the rod, screw, cap and prepared vertebrae;
FIG. 3 is a cross-sectional view taken through line 3—3 of FIG. 1;
FIG. 4 is a cross-sectional view taken through line 4—4 of FIG. 3;
FIG. 5a is a cross-sectional view taken through line 5—5 of FIG. 4 showing the rod in cross-section;
FIG. 5b is a cross-sectional view taken through line 5—5 of FIG. 4 showing an alternate rod in cross-section;
FIG. 5c is a cross-sectional view taken through line 5—5 of FIG. 4 showing an alternate rod in cross-section;
FIG. 5d is a cross-sectional view taken through line 5—5 of FIG. 4 showing an alternate rod in cross-section;
FIG. 5e is a cross-sectional view taken through line 5—5 of FIG. 4 showing an alternate rod in cross-section;
FIG. 6 is a cross-sectional view similar to FIG. 3 with an overcap design;
FIG. 7 is an end view of a corpectomy block partially cut away;
FIG. 8 is a tool for threading in the device into the annular ring recess in the vertebral body;
FIG. 9 is a perspective view of the corpectomy block of FIG. 7;
FIG. 10 is a perspective view of a wedge placable between adjacent vertebrae;
FIG. 11 is a cross-sectional view of the wedge of FIG. 10 through line 11—11;
FIG. 12 is a cross-sectional view of the wedge of FIG. 10 through line 12—12;
FIG. 13 is an alternative wedge in which a top is not planar;
FIG. 14 shows a section of a spinal column in need of realignment;
FIG. 15 shows the spinal column of FIG. 14 with a correcting wedge in place;
FIG. 16 shows a spinal column in need of alignment, such as in scoliosis; and
FIG. 17 shows the spinal column of FIG. 16 in cross-section, realigned with a correcting wedge.
With specific reference to FIGS. 1 and 2 it will be seen that an anterior spinal fixation system 10 may join adjacent vertebrae together. The system includes an elongated rod 12 and at least two hollow cylindrical screws 14. Each screw 14 includes external bone engaging threads 16, internal cap engaging threads 28, an upper rim 18 and a lower rim 20. The internal threads 28 need only be as deep as the locking cap. A smooth inner wall is preferred to avoid placing torque on the remaining bone core during insertion of the screw. As shown in FIG. 2, upper rim 18 is broken by two opposing rod fixation slots 22, 24 that are sized such that rod 12 may pass into the slots 22, 24 as shown. Preferably, the screws 14 include a plurality of bone ingrowth openings 36 through the side walls which allow bone to grow therethrough.
The rod 12 is held to the screws by a locking cap 26. As shown, locking cap 26 may be disc-shaped, having threads 30 about the circular periphery. Top 32 of the cap 26 may have a pair of spaced holes 34 to which a tool (not shown) may connect to insert said cap 26 into a hollow, threaded screw 14. Cap 26 may be threaded into said screw 14 such that no part of said cap projects beyond the screw 14. The cap may be porous and may have holes to allow bone ingrowth and increase the blood supply to the interior.
Alternatively, as shown in FIG. 6, the cap may be designed as an overcap 72 which engages with threads 74 on the outer surface of the bone screw 14. As shown, overcap 72 includes a cap projection 42 which abuts against rod 12. In the case of an overcap, some bone may be removed to accommodate the overcap as shown.
Rod 12 is preferably made of a biocompatible, malleable metal such as titanium. A rod of titanium has an advantage of having a modulus of elasticity similar to natural bone. In any case, the rod is bent by the surgeon to attain the correct configuration desired for the patient. As shown in the Figures, the rod 12 may have a plurality of spaced dimples 40 which may be round or elongated. The dimples 40 interface with a mating projection 42. In the case of a round dimple 40, the projection 42 engagement serves to prevent slippage of the rod relative to the screw 14. An elongated dimple 40 allows limited slippage which is sometimes desirable.
FIGS. 5a-e show that the cross-section of rod 12 may be nearly any shape other than round. Although a round cross-section rod would work, any non-round rod provides better torsion control. The size of the rod may be selected depending on the individual patient's size. As stated previously, the cross-sectional shape of the rod may be altered to provide stability in the proper axis of motion for a particular patient.
Installation of the device is straight forward. The surgeon exposes the vertebra 46 anteriorly and drills a cylindrical opening 50 in the vertebral bone as shown in FIG. 2. Preferably, a hole saw is used to form the opening 50, since a hole saw will leave the core 52 in place. For ease of illustration, FIG. 2 does not show a bone core 52, although the bone core 52 is shown in FIGS. 3 and 4. If a bone core 52 is not left in place, the opening may be packed with bone or bone substitute. It is noted that the bone opening 50 may be threaded if the drill used is self-tapping or it may be tapped by an additional tool used after drilling.
Preferably, the implant screws 14 are slightly larger in external diameter than the external diameter of the hole saw cut, thus providing a high friction secure linkage to the vertebral body. This also provides a screw with an internal diameter slightly larger than the outer diameter of the bone core, thus reducing the possibility of torquing the core during placement of the screw. Torquing the core in the process of insertion may destroy the blood supply to the core at its posterior surface. This would be undesirable since it may lead to delayed incorporation of the bone locking ability through the holes in the screw.
It may also be possible to use a bone screw 14 of the device to cut its own opening 50. In such a case, the screw 14 is then left in place after fully inserted.
Each of the vertebra adjacent another bone opening 50 is then cut, as by a chisel or router tool, to form a channel 54 of a depth to hold at least half the diameter of the rod 12. Although the vertebrae may be connected without the channel using the device and methods of this invention, many of the advantages are lost if at least most of the rod is not in a channel 54.
The bone screws 14 are then screwed into the bone openings 50 with threads 28, 16 on the interior and exterior of the bone screws 14 engaging vertebral bone. The screws are positioned such that the rod fixation slots 22, 24 line up with the bone channels 54. A tool 58 as shown in FIG. 8 may be used to screw the bone screws 14 into bone openings 50. As shown, tool 58 includes a shaft 60 with a handle 62 on one end a screw engaging head 64 on the other end. The screw engaging head 64 includes a pair of tabs 66, 68 that engage with slots 22, 24. The head 64 closely fits into the interior of the screw 14. No part of tool 58 projects beyond the outer circumference of the bone screws 14.
A rod 12 of the required length is then bent to the required shape and inserted into each screw via the rod fixation slots 22, 24 and into the formed bone channels 54. The rod 12 may be removed to adjust the curvature of the spine that will be defined by the installed system as needed. Once the degree of correction has been achieved, the rod is captively held in place by securing a locking cap 26 over each screw 14 thereby trapping the rod 12 in place.
The bone screws 14 are preferably placed into the vertebral bone quite deep, leaving a safety zone of about 3 mm. Depending on the size of the vertebrae, the screw diameters may range from 1.5 to 3.5 cm. Preferably, the diameter of the screws 14 is sufficient to cut into the harder, outer bone of the vertebra. The screws 14 may have a relatively thin cylindrical wall and still provide great strength and holding power.
The installed system of the invention provides a spinal correction with many important advantages. Since the cylindrical screws have far greater surface area than a conventional solid screw, the holding power is much higher. The installed system is entirely contained within the confines of the vertebral bone. Nothing projects outwardly that may contact adjacent body structures. The rod 12 is much closer to the center of the vertebral meaning that undesirable cantilever effects as in the prior art devices is greatly reduced.
The system of the invention may be used to stabilize many or only two vertebrae. It may be used to provide corrections due to rumor, fracture, degenerative disease, deformity or infection. The non-round rod used in most cases provides longitudinal rotational control. The normal healing process of the body will cause bone growth around the screws, rods and caps to lock the system even more securely to the vertebra. The screws 14 may include perforations through-out the length of the cylinder to allow bone ingrowth which may increase holding power.
FIGS. 1, 7 and 9 show that the invention may be used between two or more adjacent vertebrae and may be used in conjunction with a corpectomy block 80 which functions as a spacer for a removed vertebral body. A corpectomy block 80 is used when a large portion of the vertebral body has been removed, such as to remove tumor, fractured bone or in cases of massive bone loss. Most of the vertebra is removed anteriorly forming a gap between the remaining vertebrae. The usual prior art solution is to provide a number of fill plates with rods or a large ceramic block anchored with plates and conventional screws. U.S. Pat. No. 5,192,327 shows a suitable corpectomy block which merely needs to be designed with a slot through which the rod 12 may pass.
In FIG. 7 and 9 are corpectomy block 80 is shown in which the block is substantially hollow and is formed from a body compatible material such as titanium or ceramic. The block may be porous or at least roughened at the ends to allow bone ingrowth. A fill port 82 may be built into the block 80 to allow addition of bone graft. The block 80 includes a lengthwise slot 84 through which rod 12 may pass. In use, a block 80 of the appropriate size is fitted between the remaining vertebrae after re-section and is filled with bone graft. The rod 12 is placed through the slot 84 and is tightened at each bone screw 14 by end caps 26 or 72. This firmly holds the corpectomy block 80 in place to allow bone fusion to the adjacent vertebrae as shown in FIG. 1.
The block should allow for vascular ingrowth by having at least porous end plates 86, 88. The block 80 may be porous titanium or a ceramic with roughened end plates.
FIG. 1 shows that the invention will function even if one or more vertebra are resected and replaced with a corpectomy block. In all forms of the invention, the hollow screws 14 provide greater holding power and allow for an intramedullary rod that eliminates the cantilevered structures found in prior art pedicle screw systems such as in U.S. Pat. No. 5,324,290 that issued Jun. 28, 1994. The present invention directs the forces from nearer the center of the vertebrae and therefor the axis of forces and motion.
In some cases, the spinal column is in need of realigning, front to back, side to side, or both. FIGS. 10 through 17 show means of correcting alignment while using the spinal fixation device 10 of the invention.
In FIGS. 10-13 wedges are shown which may be inserted between the vertebrae in place of a removed disc. The wedge 90 of FIGS. 10-12 may be a solid block of ceramic, may be a titanium wedge or any other body implantable material that could replace a disc. The anterior side 92 of wedge 90 is higher than the posterior edge 94. A slot 96 is formed to allow the rod 12 to pass thereby.
The wedge 100 of FIG. 12 includes a similarly formed body, includes a slot 96 but no directional wedge. Rather, a surface 102 of wedge 100 is rounded or otherwise non-planar. In this manner, wedge 100 with surface 102 against a vertebra may allow rotational or angular correction of deformity. Wedges 100 may be inserted to replace the disc, forming a clamshell appearance in which both adjacent vertebrae would rest against a rounded surface 102.
FIGS. 14 through 17 show how a wedge of the invention may be used to correct a defect of the spinal alignment. In FIGS. 14 and 15, a spinal column consisting of vertebra 104, 106 is out of alignment with the spine pitched forwardly. In FIG. 15 each vertebra includes a screw 14, rod 12 and a wedge 90 which, by virtue of its greater anterior height, corrects the alignment. This procedure may be used instead of bending rod 12 to obtain similar results, or in conjunction with a bent rod.
FIGS. 16 and 17 show a typical scoliosis of the spine in which a corrective wedge 90 is slipped in from the side such that the thickest portion of the wedge 90 is to a side, thereby correcting the curvature. In all cases, the wedge is inserted into position, the vertebrae are allowed to contact the wedge and the locking caps 26 are screwed into engage with the rod 12 and keep the entire structure as desired.
The invention may be used anteriorly, anterior-laterally and laterally depending on the needs of the patient. The drawings show the anterior use of the bone screws as one possible position.
While this invention may embodied in many different forms, there are shown in the drawings and described in detail herein specific preferred embodiments of the invention. The present disclosure is an exemplification of the principles of the invention and is not intended to limit the invention to the particular embodiments illustrated.
This completes the description of the preferred and alternate embodiments of the invention. Those skilled in the art may recognize other equivalents to the specific embodiment described herein which equivalents are intended to be encompassed by the claims attached hereto.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4059115 *||Jun 14, 1976||Nov 22, 1977||Georgy Stepanovich Jumashev||Surgical instrument for operation of anterior fenestrated spondylodessis in vertebral osteochondrosis|
|US4289123 *||Mar 31, 1980||Sep 15, 1981||Dunn Harold K||Orthopedic appliance|
|US4448191 *||Jul 7, 1981||May 15, 1984||Rodnyansky Lazar I||Implantable correctant of a spinal curvature and a method for treatment of a spinal curvature|
|US4658809 *||Feb 24, 1984||Apr 21, 1987||Firma Heinrich C. Ulrich||Implantable spinal distraction splint|
|US4743260 *||Jun 10, 1985||May 10, 1988||Burton Charles V||Method for a flexible stabilization system for a vertebral column|
|US4790297 *||Jul 24, 1987||Dec 13, 1988||Biotechnology, Inc.||Spinal fixation method and system|
|US4805602 *||Nov 3, 1986||Feb 21, 1989||Danninger Medical Technology||Transpedicular screw and rod system|
|US4834757 *||Mar 28, 1988||May 30, 1989||Brantigan John W||Prosthetic implant|
|US4854304 *||Mar 15, 1988||Aug 8, 1989||Oscobal Ag||Implant for the operative correction of spinal deformity|
|US4865604 *||Aug 29, 1988||Sep 12, 1989||Chaim Rogozinski||Prosthetic bone joint|
|US4878915 *||Jan 4, 1989||Nov 7, 1989||Brantigan John W||Surgical prosthetic implant facilitating vertebral interbody fusion|
|US4892545 *||Jul 14, 1988||Jan 9, 1990||Ohio Medical Instrument Company, Inc.||Vertebral lock|
|US4913134 *||Jul 29, 1988||Apr 3, 1990||Biotechnology, Inc.||Spinal fixation system|
|US5007909 *||Nov 5, 1986||Apr 16, 1991||Chaim Rogozinski||Apparatus for internally fixing the spine|
|US5015247 *||Jun 13, 1988||May 14, 1991||Michelson Gary K||Threaded spinal implant|
|US5015255 *||May 10, 1989||May 14, 1991||Spine-Tech, Inc.||Spinal stabilization method|
|US5059193 *||Apr 19, 1990||Oct 22, 1991||Spine-Tech, Inc.||Expandable spinal implant and surgical method|
|US5102412 *||Jun 19, 1990||Apr 7, 1992||Chaim Rogozinski||System for instrumentation of the spine in the treatment of spinal deformities|
|US5129388 *||Feb 8, 1990||Jul 14, 1992||Vignaud Jean Louis||Device for supporting the spinal column|
|US5171279 *||Mar 17, 1992||Dec 15, 1992||Danek Medical||Method for subcutaneous suprafascial pedicular internal fixation|
|US5181917 *||Dec 3, 1991||Jan 26, 1993||Chaim Rogozinski||System and method for instrumentation of the spine in the treatment of spinal deformities|
|US5242443 *||Aug 15, 1991||Sep 7, 1993||Smith & Nephew Dyonics, Inc.||Percutaneous fixation of vertebrae|
|US5242446 *||Jan 2, 1992||Sep 7, 1993||Acromed Corporation||Connector for a spinal column corrective device|
|US5261911 *||Jul 9, 1992||Nov 16, 1993||Allen Carl||Anterolateral spinal fixation system|
|US5261913 *||Aug 25, 1992||Nov 16, 1993||J.B.S. Limited Company||Device for straightening, securing, compressing and elongating the spinal column|
|US5360431 *||Apr 26, 1990||Nov 1, 1994||Cross Medical Products||Transpedicular screw system and method of use|
|US5364399 *||Feb 5, 1993||Nov 15, 1994||Danek Medical, Inc.||Anterior cervical plating system|
|US5437669 *||Aug 12, 1993||Aug 1, 1995||Amei Technologies Inc.||Spinal fixation systems with bifurcated connectors|
|US5466237 *||Nov 19, 1993||Nov 14, 1995||Cross Medical Products, Inc.||Variable locking stabilizer anchor seat and screw|
|US5474555 *||Aug 3, 1994||Dec 12, 1995||Cross Medical Products||Spinal implant system|
|US5540688 *||Mar 8, 1994||Jul 30, 1996||Societe "Psi"||Intervertebral stabilization device incorporating dampers|
|DE4220218A1 *||Jun 20, 1992||Dec 23, 1993||S & G Implants Gmbh||Implantat mit einer offenzelligen oder offenporigen Metallstruktur|
|FR2682280A1 *||Title not available|
|WO1991016020A1 *||Apr 26, 1990||Oct 31, 1991||Danninger Medical Tech||Transpedicular screw system and method of use|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6524315 *||Aug 8, 2000||Feb 25, 2003||Depuy Acromed, Inc.||Orthopaedic rod/plate locking mechanism|
|US6607530 *||Mar 28, 2000||Aug 19, 2003||Highgate Orthopedics, Inc.||Systems and methods for spinal fixation|
|US6635087||Aug 29, 2001||Oct 21, 2003||Christopher M. Angelucci||Laminoplasty implants and methods of use|
|US7192447||Dec 19, 2002||Mar 20, 2007||Synthes (Usa)||Intervertebral implant|
|US7326200 *||Jul 25, 2003||Feb 5, 2008||Warsaw Orthopedic, Inc.||Annulus repair systems, instruments and techniques|
|US7338490||May 21, 2003||Mar 4, 2008||Warsaw Orthopedic, Inc.||Reduction cable and bone anchor|
|US7427284 *||Dec 4, 2000||Sep 23, 2008||University Of Leeds||Fixation technology|
|US7608095||Feb 12, 2003||Oct 27, 2009||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US7713301||Mar 29, 2006||May 11, 2010||Disc Dynamics, Inc.||Intervertebral disc prosthesis|
|US7766965||Jun 30, 2006||Aug 3, 2010||Disc Dynamics, Inc.||Method of making an intervertebral disc prosthesis|
|US7780703||Mar 6, 2002||Aug 24, 2010||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US7819901||Aug 31, 2005||Oct 26, 2010||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US7867232||Feb 26, 2008||Jan 11, 2011||University Of Leeds||Fixation technology|
|US7909856||May 2, 2006||Mar 22, 2011||Howmedica Osteonics Corp.||Methods for securing spinal rods|
|US7909873||Dec 14, 2007||Mar 22, 2011||Soteira, Inc.||Delivery apparatus and methods for vertebrostenting|
|US7959679||Jan 16, 2007||Jun 14, 2011||Intrinsic Therapeutics, Inc.||Intervertebral anulus and nucleus augmentation|
|US7972337||Dec 19, 2006||Jul 5, 2011||Intrinsic Therapeutics, Inc.||Devices and methods for bone anchoring|
|US7998213||Nov 17, 2006||Aug 16, 2011||Intrinsic Therapeutics, Inc.||Intervertebral disc herniation repair|
|US8002836||Sep 20, 2004||Aug 23, 2011||Intrinsic Therapeutics, Inc.||Method for the treatment of the intervertebral disc anulus|
|US8021401||Jun 20, 2003||Sep 20, 2011||K2M, Inc.||Systems, methods, devices and device kits for fixation of bones and spinal vertebrae|
|US8021425 *||Sep 20, 2011||Intrinsic Therapeutics, Inc.||Versatile method of repairing an intervertebral disc|
|US8025698||Apr 27, 2009||Sep 27, 2011||Intrinsic Therapeutics, Inc.||Method of rehabilitating an anulus fibrosus|
|US8038702||Aug 25, 2009||Oct 18, 2011||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US8105365 *||Aug 13, 2010||Jan 31, 2012||Trans1 Inc.||Methods and apparatus for performing therapeutic procedures in the spine|
|US8105384||Jun 29, 2009||Jan 31, 2012||Intrinsic Therapeutics, Inc.||Weakened anulus repair|
|US8114082||Aug 20, 2009||Feb 14, 2012||Intrinsic Therapeutics, Inc.||Anchoring system for disc repair|
|US8147521 *||Jul 20, 2006||Apr 3, 2012||Nuvasive, Inc.||Systems and methods for treating spinal deformities|
|US8231675||Feb 8, 2007||Jul 31, 2012||Synthes Usa, Llc||Intervertebral implant|
|US8231678||May 3, 2006||Jul 31, 2012||Intrinsic Therapeutics, Inc.||Method of treating a herniated disc|
|US8257437||Sep 4, 2012||Intrinsic Therapeutics, Inc.||Methods of intervertebral disc augmentation|
|US8292928||Sep 16, 2009||Oct 23, 2012||Trans1 Inc.||Method and apparatus for spinal distraction and fusion|
|US8313510||Jun 30, 2010||Nov 20, 2012||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US8317867 *||Jan 3, 2012||Nov 27, 2012||Trans1 Inc.||Methods and apparatus for performing therapeutic procedures in the spine|
|US8323341||Nov 12, 2009||Dec 4, 2012||Intrinsic Therapeutics, Inc.||Impaction grafting for vertebral fusion|
|US8353938||Dec 10, 2007||Jan 15, 2013||Warsaw Orthopedic, Inc.||Annulus repair systems, instruments and techniques|
|US8357197||Jan 9, 2006||Jan 22, 2013||Hatch Medical, L.L.C.||Percutaneous spinal stabilization device and method|
|US8357198||Jun 8, 2007||Jan 22, 2013||Hatch Medical, L.L.C.||Percutaneous spinal stabilization device and method|
|US8361155||Jan 29, 2013||Intrinsic Therapeutics, Inc.||Soft tissue impaction methods|
|US8394146||Mar 12, 2013||Intrinsic Therapeutics, Inc.||Vertebral anchoring methods|
|US8409284||Apr 2, 2013||Intrinsic Therapeutics, Inc.||Methods of repairing herniated segments in the disc|
|US8454612||Aug 20, 2009||Jun 4, 2013||Intrinsic Therapeutics, Inc.||Method for vertebral endplate reconstruction|
|US8486078||Jan 17, 2007||Jul 16, 2013||Highgate Orthopedics||Systems, devices and apparatuses for bony fixation and disk repair and replacement methods related thereto|
|US8496660||Dec 29, 2006||Jul 30, 2013||K2M, Inc.||Systems, devices and apparatuses for bony fixation and disk repair and replacement and methods related thereto|
|US8540752||Jun 27, 2008||Sep 24, 2013||Spine Tek, Inc.||Interspinous mesh|
|US8579903||Jul 13, 2007||Nov 12, 2013||K2M, Inc.||Devices and methods for stabilizing a spinal region|
|US8597356||Jun 29, 2012||Dec 3, 2013||DePuy Synthes Products, LLC||Intervertebral implant|
|US8623025||Jan 15, 2010||Jan 7, 2014||Gmedelaware 2 Llc||Delivery apparatus and methods for vertebrostenting|
|US8652177||Apr 3, 2012||Feb 18, 2014||Nuvasive, Inc.||Systems and methods for treating spinal deformities|
|US8657856||Aug 30, 2010||Feb 25, 2014||Pioneer Surgical Technology, Inc.||Size transition spinal rod|
|US8709087 *||Sep 12, 2012||Apr 29, 2014||Baxano Surgical, Inc.||Methods and apparatus for performing therapeutic procedures in the spine|
|US8808294||Sep 9, 2008||Aug 19, 2014||William Casey Fox||Method and apparatus for a multiple transition temperature implant|
|US8808327||Oct 17, 2012||Aug 19, 2014||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US8808380||Aug 27, 2007||Aug 19, 2014||William Casey Fox||Method and apparatus for an osteotomy fixation or arthrodesis cage|
|US8845728||Sep 21, 2012||Sep 30, 2014||Samy Abdou||Spinal fixation devices and methods of use|
|US9039741||Mar 7, 2013||May 26, 2015||Intrinsic Therapeutics, Inc.||Bone anchor systems|
|US9078712||Oct 30, 2009||Jul 14, 2015||Warsaw Orthopedic, Inc.||Preformed drug-eluting device to be affixed to an anterior spinal plate|
|US9192397||Jun 17, 2009||Nov 24, 2015||Gmedelaware 2 Llc||Devices and methods for fracture reduction|
|US9226832||Jan 28, 2013||Jan 5, 2016||Intrinsic Therapeutics, Inc.||Interbody fusion material retention methods|
|US9237916||Dec 14, 2007||Jan 19, 2016||Gmedeleware 2 Llc||Devices and methods for vertebrostenting|
|US20030125742 *||Feb 12, 2003||Jul 3, 2003||Howmedica Osteonics Corp.||Device for securing spinal rods|
|US20030135209 *||Dec 4, 2000||Jul 17, 2003||Bahaa Seedhom||Fixation technology|
|US20050021029 *||Jul 25, 2003||Jan 27, 2005||Trieu Hai H.||Annulus repair systems, instruments and techniques|
|US20050288671 *||Aug 31, 2005||Dec 29, 2005||Hansen Yuan||Methods for securing spinal rods|
|US20060009845 *||Jul 5, 2005||Jan 12, 2006||Chin Kingsley R||Method and device for kinematic retaining cervical plating|
|US20060195091 *||Feb 15, 2005||Aug 31, 2006||Mcgraw J K||Percutaneous spinal stabilization device and method|
|US20060195094 *||Jan 9, 2006||Aug 31, 2006||Mcgraw J K||Percutaneous spinal stabilization device and method|
|US20080033432 *||Jun 8, 2007||Feb 7, 2008||Hatch Medical, L.L.C.||Percutaneous spinal stabilization device and method|
|US20080097449 *||Dec 10, 2007||Apr 24, 2008||Trieu Hai H||Annulus repair systems, instruments and techniques|
|US20080147069 *||Feb 26, 2008||Jun 19, 2008||University Of Leeds||Fixation technology|
|US20080183300 *||Feb 26, 2008||Jul 31, 2008||University Of Leeds||Fixation technology|
|US20090112261 *||Oct 29, 2007||Apr 30, 2009||Barry Richard J||Minimally invasive spine internal fixation system|
|US20100268237 *||Jan 17, 2007||Oct 21, 2010||Highgate Orthopedics, Inc.||Systems, Devices and Apparatuses For Bony Fixation and Disk Repair and Replacement Methods Related Thereto|
|US20100268282 *||Oct 21, 2010||Warsaw Orthopedic, Inc.||Anterior spinal plate with preformed drug-eluting device affixed thereto|
|US20100305617 *||Dec 2, 2010||Trans1 Inc.||Methods and apparatus for performing therapeutic procedures in the spine|
|US20110054532 *||Jun 27, 2008||Mar 3, 2011||Alexandre De Moura||Interspinous mesh|
|US20110054535 *||Aug 30, 2010||Mar 3, 2011||Gephart Matthew P||Size Transition Spinal Rod|
|US20110196492 *||Sep 5, 2008||Aug 11, 2011||Intrinsic Therapeutics, Inc.||Bone anchoring systems|
|US20110218627 *||Mar 3, 2010||Sep 8, 2011||Warsaw Orthopedic, Inc.||System and method for replacing at least a portion of a vertebral body|
|US20120123543 *||Jan 3, 2012||May 17, 2012||Trans1 Inc.||Methods and apparatus for performing therapeutic procedures in the spine|
|US20120310282 *||Aug 13, 2012||Dec 6, 2012||Abdou M Samy||Device and method for the prevention of multi-level vertebral extension|
|US20130018473 *||Jan 17, 2013||Trans1 Inc.||Methods and apparatus for performing therapeutic procedures in the spine|
|US20130144342 *||Jun 28, 2011||Jun 6, 2013||K2M, Inc.||Spine stabilization system|
|US20140005786 *||Apr 1, 2013||Jan 2, 2014||Intrinsic Therapeutics, Inc.||Methods of repairing herniated segments in the disc|
|U.S. Classification||623/17.11, 606/907, 606/264, 606/279, 606/261, 606/247, 606/271, 606/272|
|International Classification||A61B17/58, A61F2/28, A61F2/44, A61B17/70, A61B17/88, A61F2/30, A61F2/00, A61F2/46|
|Cooperative Classification||A61F2002/30125, A61F2002/30154, A61F2230/0021, A61F2002/30507, A61F2002/4623, A61F2002/3085, A61F2002/30225, A61B17/70, A61B17/7032, A61F2230/0017, A61F2002/30785, A61F2/4465, A61F2002/3038, A61F2002/4475, A61F2002/30616, A61F2230/0008, A61F2002/2835, A61F2002/30143, A61F2/442, A61F2230/0013, A61F2/4425, A61F2/4611, A61F2002/449, A61B17/701, A61F2002/30131, A61F2002/3082, A61F2230/0069, A61F2002/464, A61F2002/30594, A61F2230/0026, A61F2220/0025, A61F2230/0023, A61F2/446, A61F2002/30235, A61F2310/00023, A61B17/7076, A61F2/44, A61F2002/30329, A61F2/30744, A61F2230/0034, A61F2002/30405, A61F2002/30158, A61F2002/30156, A61F2002/30187, A61F2002/3023, A61F2220/0033, A61F2310/00179|
|European Classification||A61F2/44, A61B17/70B1E, A61F2/44D, A61B17/70, A61F2/44F4, A61B17/70B2, A61F2/46B7, A61F2/30B9, A61B17/70T2|
|May 9, 2005||FPAY||Fee payment|
Year of fee payment: 8
|May 9, 2005||SULP||Surcharge for late payment|
|Jun 27, 2005||PRDP||Patent reinstated due to the acceptance of a late maintenance fee|
Effective date: 20011218
|Jun 27, 2008||FPAY||Fee payment|
Year of fee payment: 12
|Jul 13, 2012||AS||Assignment|
Effective date: 20120706
Owner name: VENTURE BANK, MINNESOTA
Free format text: SECURITY AGREEMENT;ASSIGNOR:SPINEOLOGY INC.;REEL/FRAME:028550/0391