|Publication number||USRE37704 E1|
|Application number||US 09/534,842|
|Publication date||May 14, 2002|
|Filing date||Mar 28, 2000|
|Priority date||Mar 22, 1990|
|Publication number||09534842, 534842, US RE37704 E1, US RE37704E1, US-E1-RE37704, USRE37704 E1, USRE37704E1|
|Original Assignee||Argomed Ltd.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (173), Non-Patent Citations (3), Referenced by (19), Classifications (35), Legal Events (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is for a continuation-in-part of my prior patent application Ser. No. 07/669,366, filed Mar. 14, 1991 now U.S. Pat. No. 5,257,977.
The present invention relates to thermal treatment apparatus for thermally treating selected tissues of a subject. The invention is particularly useful as a thermal treatment apparatus for treating prostate, bladder and uterus, and is described below particularly with respect to an apparatus for treating the prostate. The invention also relates to a catheter construction, a heater, a peristaltic pump, and a thermal sensor assembly, all especially useful in the novel thermal treatment apparatus.
Thermal treatment is now a recognized form of treatment of certain types of ailments including benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer. My prior U.S. application Ser. No. 07/669,366, filed Mar. 14, 1991, now U.S. Pat. No. 5,257,977 discloses one form of thermal treatment apparatus including a catheter insertable into the subject's urethra. The proximal end of the catheter includes an inflatable anchoring section in the form of a balloon to be anchored in the subjects bladder, and a heating section which, when the balloon is so anchored, extends through the subject's prostate. A heated liquid, such as water, is used to inflate the balloon and is also circulated through the heating section to heat the adjacent tissues of the prostate and the bladder neck.
The present invention relates to this type of thermal treatment apparatus but provides a number of important advantages, as will be described more particularly below.
According to the present invention, there is provided a thermal treatment apparatus for thermally treating selected tissues of a subject located in or near a body cavity, comprising a catheter insertable into the subject's body cavity and including a proximal end formed with an inflatable anchoring section for anchoring the catheter in the body cavity, a distal end to be located externally of the body cavity, and an inflatable heating section adjacent the proximal end to be located near the tissue to be heated. The catheter is formed with first and second passageways extending from the distal end to the, inflatable heating section for circulating heated fluid through the inflatable heating section but not through the inflatable anchoring section; and a third passageway from the distal end to the inflatable anchoring section for inflating the inflatable anchoring section with a non-heated fluid, whereby the inflatable heating section and the tissue in its proximity may be heated to a desired high temperature without correspondingly heating the inflatable anchoring section and the tissue in its proximity.
By thus inflating the anchoring section at the proximal end of the catheter with a separate, non-heated fluid, the heating fluid may be more particularly targeted, by the inflatable heating section, to the tissue to be subjected to the thermal treatment, thereby enabling higher temperatures to be applied if desired.
According to a another aspect of the invention, there is provided a thermal treatment apparatus for thermally treating selected tissues of a subject located in or near a body cavity, comprising: a catheter insertable into the subject's body cavity and including a proximal end having an inflatable anchoring section for anchoring the catheter in the body cavity, a distal end to be located externally of the body cavity, and an inflatable heating section adjacent the proximal end to be located near the tissue to be heated; first and second passageways from the distal end to the inflatable heating section for circulating heated fluid through the inflatable heating section but not through the inflatable anchoring section; a first thermal sensor assembly near the inlet end of the first passageway for measuring the temperature of the heated fluid entering the first passageway; and a second thermal sensor assembly near the outlet end of the second passageway for measuring the temperature of the heated liquid exiting from the second passageway.
More particularly, each of the two thermal sensor assemblies includes: a thermal sensor, a metal tube connectable to the respective end of the respective passageway of the catheter to receive the heated fluid flowing therethrough; a metal thermal coupling member formed with a recess on one face for receiving the thermal sensor therein, a recess on the opposite face complementary to the shape of the metal tube for receiving the metal tube therein, and a relatively thin web between the two recesses; and a cover pressing the metal tube to the metal thermal coupling member.
According to a still further aspect of the invention, there is provided a liquid heater which is particularly useful in such thermal treatment apparatus and including a heating block formed with a semi-spherical cavity; a container defining a liquid reservoir and also formed with a semispherical wall removably receivable in the cavity of the heating block; a cover attached to the container; a liquid inlet tube passing through the cover for inletting a liquid into the container to be heated by the heating block; and a liquid outlet tube passing through the cover for outletting a liquid from the container after having been heated by the heating block.
According to a further aspect of the invention, there is provided a peristaltic pump particularly useful in thermal treatment apparatus, which peristaltic pump includes a housing formed with a cylindrical cavity; and a rotor rotatably mounted within the cavity and carrying rollers engageable with a peristaltic tube insertable into the cavity for pressing the peristaltic tube against a wall of the housing in order to pump a liquid through the peristaltic tube during the rotation of the rotor; the wall of the housing including a skirt depending from a lid removably received over the cylindrical cavity; the depending skirt extending less than the circumference of the lid to produce an interruption in the housing wall against which the peristaltic tube is pressed by the rollers of the rotor.
Further features and advantages of the invention will be apparent from the description below.
The invention is herein described, by way of example only, with reference to the accompanying drawings, wherein:
FIG. 1 is a block diagram illustrating the main components of a thermal treatment apparatus constructed in accordance with the present invention;
FIG. 2 is a view, partially in longitudinal section diagrammatically illustrating one form of catheter constructed in accordance with the present invention for use in the thermal treatment apparatus of FIG. 1;
FIG. 3 is a view, partially in longitudinal section and rotated 90° with respect to FIG. 2, illustrating the catheter of FIG. 2;
FIGS. 4, 5 and 6 are transverse sectional views along lines IV—IV, V—V and VI—VI in FIG. 3;
FIG. 7 is a bottom view illustrating one form of liquid heater constructed in accordance with the invention for use in the thermal treatment apparatus of FIG. 1;
FIG. 7a is a sectional view along line VIIa—VIIa of FIG. 7;
FIG. 8 is a longitudinal sectional view along line VIII—VIII of FIG. 9, and FIG. 9 is a transverse sectional view along line IX—IX of FIG. 8, of one form of peristaltic pump constructed in accordance with the invention, FIG. 9a being a fragmentary detail view along line IXa—IXa of FIG. 9;
FIG. 10 is a transverse sectional view along line X—X of FIG. 11, and FIG. 11 is a longitudinal sectional view along line XI—XI of FIG. 10, illustrating one form of thermal sensor assembly constructed in accordance with the invention for use in the thermal treatment apparatus of FIG. 1.
The thermal treatment apparatus diagrammatically illustrated in FIG. I includes a catheter 2 insertable into a subject's body cavity to be treated thermally. In the example to be described below, the heat is applied to treat the prostate. The catheter 2 would therefore be inserted into the subject's urethra, such that one end of the catheter is anchored in the subject's bladder. This locates a heating section of the catheter in the subject's prostate.
The thermal treatment apparatus illustrated in FIG. 1 further includes a heater 4 for heating a fluid, in this case a liquid such as water, to be circulated in a closed circuit through the heating section of the catheter by means of a pump 6, The temperature of the heating liquid inletted from pump 6 into the catheter 2 is measured by a thermal sensor assembly 8, and the temperature of the liquid exiting from the catheter 2 to the heater 4 is measured by another thermal sensor assembly 10. The illustrated apparatus further includes a controller 12 which controls both the heater 4 and the pump 6 in response to the temperature sensed by sensor assemblies 8 and 10 and another sensor (to be described below) in the heater 4.
The construction of the catheter 2 is shown in FIGS. 2-6; the construction of the liquid heater 4 is shown in FIGS. 7 and 7a; the construction of the pump 6 is shown in FIGS. 8, 9 and 9 a; and the construction of the two thermal sensor assemblies 8 and 10 is shown in FIGS. 10 and 11.
The catheter 2, as shown in FIGS. 2-6, includes a long slender tube 20 formed with an inflatable anchoring section 21 at the proximal end for anchoring the catheter in the subject's bladder, and thereby for locating an inflatable cylindrical heating section 22 extending through the subject's prostate when the catheter is so anchored. The opposite end of the catheter, called the distal end, is to be located externally of the subject's urethra so as to be readily accessible for inflating the proximal anchoring section 21 and for inflating and circulating a heating liquid through the inflatable heating section 22.
The heating liquid is circulated through the inflatable heating section 22 via two passageways 24 a, 24 b having an inlet 25 and an outlet 26 at the distal end 23 of the catheter. The inflatable anchoring section 21 of the catheter is inflated by an unheated fluid, such as air, introduced via an inlet 27 at the distal end 23 and communicating with the anchoring section 21 via the third passageway 28 and an opening 29.
The portion of the catheter from the distal end 23 to the inflatable heating section 22 is thermally insulated from the subject's tissue by means of outer chambers 30, 30 a and 30 b enclosing passageways 24 a, 24 b, referred to generically by numeral 24, through which the heating liquid is circulated to the heating section 22. One of these chambers communicates with passageway 28 through which unheated air is applied to inflate the anchoring section 21.
The catheter also includes an extension 31 at the proximal end, which extension is received within the subject's bladder. Extension 31 is formed with an opening 32 for draining the subject's bladder via a passageway 33 passing through the length of the catheter and terminating in an outlet 34 at the distal end 23 of the catheter for connection to a drain. Extension 31 and its passageway 33 may also be used for introducing a drug into the bladder if desired.
The Heater 4 (FIG. 7)
The liquid heater 4, as more particularly illustrated in FIG. 7, includes a heating block 40 made of a good heat-conducting material, such as aluminum. Heating block 40 is of dome shape to define a smoothly curved semi-spherical cavity 41, and is integrally formed with four perpendicular ribs 42. A plurality of electrical heating elements 43, and one or more thermal sensors 44, are encased within the heating block 40. As seen in FIG. 7, an electrical heating element 43 is encased in each of the four ribs 42, and thermal sensor 44 is encased in each of the two opposite sides of the heating block, midway between two heating elements 43. The dome-shaped section of the heating block is relatively thin, as shown at 45 in FIG. 7a, to thereby reduce its thermal mass.
The heating block 40 illustrated in FIG. 7a further includes a removable container 50 serving as a water reservoir and formed with a complementary-curved wall 51, i.e., of semi-spherical configuration corresponding to the semi-spherical configuration of cavity 41. The semi-spherical wall 51 of container 50, however, is of slightly smaller dimensions than the heating block cavity 41 so as to provide a small gap 52 adapted to receive a small quantity of a liquid 53 to provide a good thermal coupling between block 40 and container wall 51. The semi-spherical shape of the container wall 51 permits it to be of a thin- wall construction and therefore sufficiently inexpensive so as to be disposable after one-time use. The thinness of the plastic wall also provides good thermal conductivity between heating block 40 and the interior of container 50.
Container 50 further includes a cover 54, preferably bonded by an adhesive or solvent or welded to the curved wall 51 of the container. Cover 54 is formed with a reentry tube 55 substantially centrally of the cover for receiving an inlet tube 56 which inlets into the container the liquid to be heated by the heating block 40. A second reentry tube 57 is formed in cover 54 laterally Of reentry tube 55, for receiving the outlet tube 58 which outlets the liquid from the container. The inlet reentry tube 55 extends from cover 54 substantially to the bottom of the container 50, whereas the outlet reentry tube 57 terminates close to the top of the container 50. This arrangement provides a relatively large residence time and contact surface for heating the liquid as it is circulated within container 50 from the inlet 56 to the outlet 58.
The Peristaltic Pump 6 (FIGS. 8, 9 and 9 a)
Pump 6 in FIG. 1 is a peristaltic pump as more particularly illustrated in FIGS. 8, 9 and 9 a. It includes a housing 60 formed with a cylindrical cavity 61. Disposed within cylindrical cavity 61 is a rotor 62 connected by a drive shaft 63 to a gear motor (not shown) and including a pair of spaced discs 64 a, 64 b rotatably mounting between them a plurality (3) of rollers 65 within cavity 61. Also located within the cylindrical cavity 61 is a peristaltic tube 66 which is engageable by the roller 65 for pumping the liquid through the tube during the rotation of rotor 62. Assuming rotor 62 is rotated counter-clockwise in FIG. 9, the liquid will be pumped through the peristaltic tube 66 from an inlet nipple 67 to an outlet nipple 68.
As shown in FIG. 8, housing 60 further includes a lid 70 formed with a large central opening 71 for accommodating disc 64 of the rotor 62. Lid 70 is formed with a depending skirt 72 which extends into the cylindrical cavity 61 such that the peristaltic tube 66 is located between the inner surface of skirt 72 and the rollers 65. Skirt 72 extends only for a part of the circumference of the lid, e.g., from 160° to 200°, to accommodate the inlet and outlet ends of the peristaltic tube 66. As shown in FIG. 9, skirt 72 extends slightly more than 180°; also, its leading edge 73 and its trailing edge 74 are tapered to provide a gradual application of the pressure to the peristaltic tube by the roller 65, and a gradual release of the pressure.
Housing 60 is of polygonal, preferably square, cross-section to provide a flat surface 60 a. Lid 70 is provided with a depending pin 75 in contact with the outer flat surface 60 a of housing 60 (see FIGS. 9 and 9a) to prevent rotation of the lid during the rotation of the rotor 62.
The illustrated construction, including the depending skirt 72, facilitates the assembly of the peristaltic pump with the peristaltic tube 66 between the skirt and the rollers 65. Thus, with the lid removed the peristaltic tube 66 may be conveniently applied around the rollers 65. The lid 70 may then be applied with its skirt 72 received between the peristaltic tube 66 and the inner surface of the cylindrical cavity 61 formed in housing 60, so as to squeeze the tube between it and the rollers 65. For this purpose, the lower edge of skirt 72 is tapered, as shown at 76 in FIGS. 8 and 9a, to facilitate the application of the skirt.
The foregoing construction not only facilitates the assembly of the peristaltic pump, but also covers the rollers 65 to minimize exposure to a person's fingers or the like. In addition, the thickness of skirt 72 influences the outlet pressure produced by the pump, so that lids 70 with different thickness skirts 72 may be provided to provide different outlet pressures. In addition, the inner surface of the skirt 72 may be provided with one or more grooves, as shown at 77 in FIG. 9, to produce a pulsatile output.
The thermal sensors assemblies 8, 10
The thermal sensor assemblies 8, 10 are more particularly illustrated in FIGS. 10 and 11. They are both enclosed within a common housing 80 in the shape of an “H” and closed by a common cover 31. Thermal sensor assembly 8 near the inlet end of the catheter 2 includes a thermal sensor element 82 received within a rectangular recess formed in a metal thermal coupling member 83. The opposite face of the coupling member is formed with a recess for receiving a metal tube 84 connectable to an inlet tube 85 near the inlet end of the catheter. Thermal sensor assembly 10 similarly includes a thermr al sensor element 86 received within a recess formed in another thermal coupling member 87. The opposite face of member 87 is similarly formed with a recess for receiving a metal tube 88 adapted to be coupled to an outlet tube 89 near the outlet end of the catheter. Electrical connections are made to the two thermal sensor elements 82 and 86 via a cable 90 leading to the controller 12 in FIG. 1.
The two thermal coupling members 83, 87, as well as the two tubes 84, 88, are of a metal, such as stainless steel, having relatively good thermal conductivity. The coupling members 83, 87 include relatively thin web portions 83 a, 87 a, respectively, between the thermal sensor elements 82, 86 and the metal tubes 84, 88, so as to provide a good thermal coupling between the liquid flowing through the two metal tubes and their respective thermal sensor elements. The cover 81, fixed to the common H-shaped housing 80 in any suitable manner, presses the metal tubes 94, 88 firmly against their respective metal coupling members 83, 87.
The overall operation of the thermal treatment apparatus illustrated in the drawings is as follows:
The catheter 2 is inserted into the urethra of the subject until the inflatable anchoring section 21 at the proximal end passes through the subject's bladder neck. An unheated fluid, preferably air, is introduced via inlet 27 and passageway 28 into the interior of the anchoring section 21 to inflate it. This anchors section 21 in the subject's bladder, wherepon the cylindrical heating section 22 of the catheter extends through the subject's prostate.
A heating fluid, such as water, is then pumped from the container 50 via pump 6 into the inlet 25 of passageway 24 a, to fill the catheter and to inflate the cylindrical heating section 22 of the catheter. Additional water is added to the catheter (e.g., via a separate inlet in the connector connecting the catheter to the closed circuit) to completely fill the closed circuit including container 50 and the catheter 2. The water heated within container 50 is circulated by the peristaltic pump 6 through the closed circuit including the cylindrical heating section 22 of the catheter.
During the circulation of the heating liquid, the sensor assemblies 8, 10 sense the temperature of the heating liquid near the inlet and outlet ends of the catheter, respectively. These sensor assemblies, together with the thermal sensors 44 in the electrical heater 4, control the controller 12 to maintain the desired temperature. Only the inflated heating section 22 of the catheter is effective to heat tissue, because of the thermal insulation provided by the unheated air within the anchoring section 21 of the catheter, and within chambers 30 of the remaining portion of the catheter. Accordingly, the liquid applied to the inflatable heating section 22 may be heated to a relatively high temperature for application to the tissue within the prostate, with less danger of unduly heating other tissue contacted by the catheter. The inflation of the heating section 22 of the catheter also presses that section firmly against the tissue to be thermally treated thereby further enhancing the heating effects.
Drain opening 32 at the proximal end of the catheter, and passageway 33 through the catheter, provide a drain for the bladder liquids or enable the introduction of a drug into the bladder.
While the invention has been described with respect to one preferred embodiment, it will be appreciated that many other variations, modifications and applications of the invention may be made.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US612724||Jun 4, 1897||Oct 18, 1898||Bert j|
|US827099||Jul 8, 1905||Jul 31, 1906||Frederick Hofmann||Medical device.|
|US899477||Oct 26, 1907||Sep 22, 1908||William Bryant||Dilator and applicator.|
|US1011606||Mar 5, 1910||Dec 12, 1911||Jacob A Fulton||Appliance for subjecting portions of the human system to heat or cold.|
|US1393153||Jan 14, 1921||Oct 11, 1921||Fox Morris John||Device for treatment by temperature|
|US1584464||Mar 7, 1923||May 11, 1926||Maranville Clarence H||Medicinal applicator|
|US1620929||Feb 5, 1925||Mar 15, 1927||Wallerich George W||Heat-therapy method and means|
|US1652954||Mar 29, 1926||Dec 13, 1927||Pierce Charles C||Prostate applicator|
|US1690995||Dec 28, 1927||Nov 6, 1928||Monte Lloyd Corp||Anorectal dilator|
|US1764838||Nov 3, 1928||Jun 17, 1930||Newton H Horne||Hydraulic pulsator|
|US1786373||Nov 30, 1929||Dec 23, 1930||Walker Ralph C||Electrically-heated therapeutical appliance|
|US1827306||Sep 14, 1925||Oct 13, 1931||Fischer & Co H G||Electrode|
|US1904020||Oct 26, 1929||Apr 18, 1933||Wappler Reinhold H||Temperature controlling apparatus|
|US2024301||Sep 21, 1934||Dec 17, 1935||Norwood Robert R||Surgical appliance|
|US2026747||Mar 16, 1935||Jan 7, 1936||William P B Nemzek||Gravity thermal dilator|
|US2043083||Jul 8, 1932||Jun 2, 1936||Charles Wappler Frederick||Therapeutic electrode and plug therefor|
|US2058780||Mar 28, 1931||Oct 27, 1936||Elliott Charles Robert||Thermo-therapeutical method and apparatus|
|US2074634||May 27, 1935||Mar 23, 1937||Henri Ackermann||Tubular heating device for gynecological purposes|
|US2076638||Apr 25, 1936||Apr 13, 1937||Haynos John J||Prostate gland massaging and variable temperature applicator|
|US2077453||Mar 29, 1934||Apr 20, 1937||American Anode Inc||Therapeutical appliance|
|US2078786||Dec 17, 1934||Apr 27, 1937||Mason Wood Glen||Applicator and control means therefor|
|US2103371||Apr 21, 1934||Dec 28, 1937||Kleckner Arthur C||Therapeutic device|
|US2168427||May 25, 1937||Aug 8, 1939||Mcconkey Walter N||Thermal dilator|
|US2190383||Aug 29, 1936||Feb 13, 1940||Newman Louis B||Therapeutic apparatus|
|US2190384||Jul 6, 1937||Feb 13, 1940||Newman Louis B||Therapeutic bag|
|US2192768||Jun 20, 1939||Mar 5, 1940||Cross Thomas J||Therapeutical heating device|
|US2466042||Aug 26, 1947||Apr 5, 1949||Nechtow Mitchell J||Internal heat-treatment device|
|US2734508||Mar 29, 1954||Feb 14, 1956||Kozinski|
|US2777442||Apr 11, 1955||Jan 15, 1957||Joseph Zelano||Nasal filter|
|US2777445||Jul 12, 1952||Jan 15, 1957||Electronic Medical Foundation||Electrical therapeutical device for internal application|
|US2849001||Oct 17, 1955||Aug 26, 1958||Vincent J Oddo||Haemostatic catheter|
|US3154077||Jun 4, 1962||Oct 27, 1964||Joseph P Cannon||Hemostatic device for anal surgery|
|US3227154||May 11, 1962||Jan 4, 1966||Galen B Cook||Diagnostic bag with impressionable outer surface and method of using it|
|US3369549||Oct 5, 1965||Feb 20, 1968||Thomas A. Armao||Capsule probe having thermoelectric heat exchange means therein|
|US3417746||Feb 27, 1968||Dec 24, 1968||Welch Allyn Inc||Illuminating endoscope with disposable elements|
|US3625793||Sep 23, 1969||Dec 7, 1971||David S Sheridan||Balloon-type catheters and method of manufacture|
|US3645265||Jun 25, 1969||Feb 29, 1972||Majzlin Gregory||Intrauterine cauterizing device|
|US3811450||Oct 25, 1972||May 21, 1974||P Lord||Catheters|
|US3848602||Apr 19, 1972||Nov 19, 1974||Gutnick Morton||Abortion facilitating device and process|
|US3848607||Jun 8, 1973||Nov 19, 1974||M Clair||Therapeutic apparatus|
|US4091672||Jun 9, 1977||May 30, 1978||Sarns, Inc.||Temperature probe and connector|
|US4112943||Mar 26, 1975||Sep 12, 1978||Adams Robbie J||Therapeutic assembly|
|US4137922||May 21, 1975||Feb 6, 1979||Ortho Pharmaceutical Corp.||Dilator for cervical canal|
|US4143649||Jan 24, 1977||Mar 13, 1979||George Foti||Pump for closed circulation system|
|US4160455||Jul 13, 1977||Jul 10, 1979||Ferranti Limited||Heater for heating fluid in a body cavity|
|US4185948||Nov 30, 1977||Jan 29, 1980||Maguire Stephen B||Peristaltic pump construction|
|US4244377||Oct 19, 1978||Jan 13, 1981||Grams Guenter A||Ear probe for use in closed-loop caloric irrigation|
|US4335726||Jul 11, 1980||Jun 22, 1982||The Kendall Company||Therapeutic device with temperature and pressure control|
|US4367747||Oct 1, 1980||Jan 11, 1983||Lothar Witzel||Pneumatic dilatator for introdution into the esophagus|
|US4469103||Mar 3, 1982||Sep 4, 1984||Barrett Harold F||Method of treating conditions such as tumors in living bodies|
|US4530647||Feb 8, 1984||Jul 23, 1985||Unolab Co., Ltd.||Peristaltic pump having conical rollers|
|US4552557||Oct 21, 1983||Nov 12, 1985||Avvari Rangaswamy||Inflatable uterine hemostat|
|US4574752||Oct 15, 1984||Mar 11, 1986||Marvion E. Reichert, Jr.||Internal combustion engine shutdown device|
|US4610660||Dec 18, 1984||Sep 9, 1986||The Kendall Company||Method of performing a nephrostomy procedure with connector assembly|
|US4628931||May 18, 1984||Dec 16, 1986||Barrett Harold F||Medical treatment method|
|US4636195||Apr 4, 1985||Jan 13, 1987||Harvey Wolinsky||Method and apparatus for removing arterial constriction|
|US4655746||Dec 2, 1985||Apr 7, 1987||Target Therapeutics||Catheter device|
|US4662368||Jun 28, 1985||May 5, 1987||Trimedyne Laser Systems, Inc.||Localized heat applying medical device|
|US4671795||Nov 19, 1984||Jun 9, 1987||Mulchin William L||Permanent/retrievable ureteral catheter|
|US4672962||Oct 7, 1985||Jun 16, 1987||Cordis Corporation||Plaque softening method|
|US4676258||Jun 5, 1986||Jun 30, 1987||Kureha Kagaku Kogyo Kabushiki Kaisha||Device for hyperthermia|
|US4686965||Jan 31, 1986||Aug 18, 1987||Richard Wolf Gmbh||Instrument for endoscopic operations|
|US4686985||Apr 24, 1986||Aug 18, 1987||Lottick Edward A||Anal dilator and occluder|
|US4709698||May 14, 1986||Dec 1, 1987||Thomas J. Fogarty||Heatable dilation catheter|
|US4710169||Dec 11, 1985||Dec 1, 1987||Christopher T Graham||Urinary catheter with collapsible urethral tube|
|US4754752||Jul 27, 1987||Jul 5, 1988||Robert Ginsburg||Vascular catheter|
|US4787388||Nov 26, 1986||Nov 29, 1988||Schneider - Shiley Ag||Method for opening constricted regions in the cardiovascular system|
|US4793351||Jun 15, 1987||Dec 27, 1988||Mansfield Scientific, Inc.||Multi-lumen balloon catheter|
|US4793352||May 11, 1987||Dec 27, 1988||Eichenlaub John E||Limited heat transfer device and method|
|US4799479||Jan 8, 1987||Jan 24, 1989||The Beth Israel Hospital Association||Method and apparatus for angioplasty|
|US4819751||Oct 16, 1987||Apr 11, 1989||Baxter Travenol Laboratories, Inc.||Valvuloplasty catheter and method|
|US4823812||May 5, 1987||Apr 25, 1989||Biodan Medical Systems Ltd.||Applicator for insertion into a body opening for medical purposes|
|US4824436||Apr 21, 1987||Apr 25, 1989||Harvey Wolinsky||Method for the prevention of restenosis|
|US4832691||Mar 12, 1987||May 23, 1989||Lothar Witzel||Pneumatic bougie, particularly for treatment of stenoses|
|US4860744||Nov 2, 1987||Aug 29, 1989||Raj K. Anand||Thermoelectrically controlled heat medical catheter|
|US4865047||Jun 30, 1988||Sep 12, 1989||City Of Hope||Hyperthermia applicator|
|US4893623||Nov 20, 1987||Jan 16, 1990||Advanced Surgical Intervention, Inc.||Method and apparatus for treating hypertrophy of the prostate gland|
|US4932938||May 5, 1989||Jun 12, 1990||Medical Engineering Corporation||Urethral indwelling catheter with incontinence control|
|US4932956||May 4, 1989||Jun 12, 1990||American Medical Systems, Inc.||Prostate balloon dilator|
|US4946449||Dec 18, 1986||Aug 7, 1990||Davis Jr Richard C||Indwelling urethral catheter system and method|
|US4949718||Sep 9, 1988||Aug 21, 1990||Gynelab Products||Intrauterine cauterizing apparatus|
|US4950227||Nov 7, 1988||Aug 21, 1990||Boston Scientific Corporation||Stent delivery system|
|US4955859||Jul 7, 1989||Sep 11, 1990||C. R. Bard, Inc.||High-friction prostatic stent|
|US4967765||Jul 28, 1988||Nov 6, 1990||Bsd Medical Corporation||Urethral inserted applicator for prostate hyperthermia|
|US4973301||Jul 11, 1989||Nov 27, 1990||Israel Nissenkorn||Catheter and method of using same|
|US4995872||Oct 4, 1989||Feb 26, 1991||Ferrara Janice J||Expandable catheter and bridge device|
|US5007437||Apr 19, 1990||Apr 16, 1991||Mmtc, Inc.||Catheters for treating prostate disease|
|US5019075||Jul 31, 1990||May 28, 1991||The Beth Israel Hospital||Method and apparatus for angioplasty|
|US5035694||May 15, 1989||Jul 30, 1991||Advanced Cardiovascular Systems, Inc.||Dilatation catheter assembly with heated balloon|
|US5041092||Oct 30, 1990||Aug 20, 1991||Medical Engineering Corporation||Urethral indwelling catheter with magnetically controlled drainage valve and method|
|US5045056||Sep 15, 1989||Sep 3, 1991||Behl Robert S||Method and device for thermal ablation of hollow body organs|
|US5059169||Jul 24, 1990||Oct 22, 1991||C. R. Bard, Inc.||High-friction prostatic stent|
|US5061241||Feb 8, 1991||Oct 29, 1991||Stephens Jr Harry W||Rapid infusion device|
|US5084044||Jul 14, 1989||Jan 28, 1992||Ciron Corporation||Apparatus for endometrial ablation and method of using same|
|US5098374||Sep 2, 1988||Mar 24, 1992||Engineers & Doctors A/A||Device for the placing of a partial catheter in a body cavity|
|US5105808||Aug 9, 1990||Apr 21, 1992||Gynelab Products||Intrauterine cauterizing method|
|US5112306||Dec 27, 1989||May 12, 1992||American Medical Systems, Inc.||Method and apparatus for valving body fluids|
|US5151100||Jul 3, 1990||Sep 29, 1992||Boston Scientific Corporation||Heating catheters|
|US5159925||Jan 28, 1991||Nov 3, 1992||Gynelab, Inc.||Cauterizing apparatus and method for laparoscopic cholecystostomy, gallbladder ablation and treatment of benign prostate hypertrophy|
|US5176626||Jan 15, 1992||Jan 5, 1993||Wilson-Cook Medical, Inc.||Indwelling stent|
|US5188596||Sep 27, 1990||Feb 23, 1993||Mentor Corporation||Transparent prostate dilation balloon and scope|
|US5195565||Oct 11, 1991||Mar 23, 1993||Elopak Systems A.G.||Variable stroke lifter system|
|US5195965||Mar 7, 1991||Mar 23, 1993||Shantha Totada R||Method and apparatus for localized treatment of human viral infections and cancers|
|US5220927||Mar 15, 1990||Jun 22, 1993||Bsd Medical Corporation||Urethral inserted applicator for prostate hyperthermia|
|US5234004||Mar 12, 1991||Aug 10, 1993||Technomed International||Method and apparatus for the surgical treatment of tissues by thermal effect, and in particular the prostate, using a urethral microwave-emitting probe means|
|US5257977||Mar 14, 1991||Nov 2, 1993||Argomed Ltd.||Technique for localized thermal treatment of mammals|
|US5269758||Apr 29, 1992||Dec 14, 1993||Taheri Syde A||Intravascular catheter and method for treatment of hypothermia|
|US5269802||Sep 10, 1991||Dec 14, 1993||Garber Bruce B||Prostatic stent|
|US5281213||Apr 16, 1992||Jan 25, 1994||Implemed, Inc.||Catheter for ice mapping and ablation|
|US5286259||Feb 18, 1992||Feb 15, 1994||Diagnostic Devices Group Limited||Dual-diameter multifunction catheter|
|US5306241||Dec 13, 1991||Apr 26, 1994||Samples Charles R||Method of catheterization on and bladder drainage|
|US5312343||Nov 23, 1990||May 17, 1994||Michael Krog||Device for segmental perfusion and aspiration of colon and rectum|
|US5314443||Jan 21, 1993||May 24, 1994||Meadox Medicals, Inc.||Prostate balloon dilatation catheter|
|US5322501||Oct 2, 1992||Jun 21, 1994||Mahmud Durrani Ayaz||Continent urethral stent for treating and preventing urethral stricture after surgery|
|US5328471||Aug 4, 1993||Jul 12, 1994||Endoluminal Therapeutics, Inc.||Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens|
|US5372600||May 10, 1993||Dec 13, 1994||Instent Inc.||Stent delivery systems|
|US5385540||May 26, 1993||Jan 31, 1995||Quest Medical, Inc.||Cardioplegia delivery system|
|US5391196||Jun 18, 1993||Feb 21, 1995||Devonec; Marian||Method for therapeutic treatment of an obstructed natural canal|
|US5403281||Sep 25, 1992||Apr 4, 1995||Minnesota Mining And Manufacturing Company||Inline heat exchanger and cardioplegia system|
|US5419763||Jan 4, 1994||May 30, 1995||Cortrak Medical, Inc.||Prostatic drug-delivery catheter|
|US5431648||Nov 10, 1992||Jul 11, 1995||Fondazione Centro S. Raffaele Del Monte Tabor||Radiating device for hyperthermia|
|US5439446||Jun 30, 1994||Aug 8, 1995||Boston Scientific Corporation||Stent and therapeutic delivery system|
|US5451218||Mar 2, 1994||Sep 19, 1995||Moore; Patrick S.||Urinary drainage device|
|US5478349||Apr 28, 1994||Dec 26, 1995||Boston Scientific Corporation||Placement of endoprostheses and stents|
|US5480417||May 24, 1993||Jan 2, 1996||Technomed Medical Systems||Method and apparatus for the surgical treatment of tissues by thermal effect, and in particular the prostate, using a urethral microwave-emitting probe means|
|US5496271||Jun 16, 1993||Mar 5, 1996||American Medical Systems, Inc.||Combined hyperthermia and dilation catheter|
|US5496311||May 2, 1994||Mar 5, 1996||Boston Scientific Corporation||Physiologic low stress angioplasty|
|US5499994||Apr 28, 1994||Mar 19, 1996||American Medical Systems, Inc.||Dilation device for the urethra|
|US5509929||Oct 6, 1992||Apr 23, 1996||Technomed Medical Systems||Urethral probe and apparatus for the therapeutic treatment of the prostate by thermotherapy|
|US5514092||Aug 8, 1994||May 7, 1996||Schneider (Usa) Inc.||Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration|
|US5514095||Apr 4, 1994||May 7, 1996||Haemonetics Corporation||Apparatus for heating, filtering and eliminating gas from biological fluids|
|US5514178||May 27, 1994||May 7, 1996||Synthelabo||Prosthesis for bodily canal|
|US5518498||Oct 7, 1993||May 21, 1996||Angiomed Ag||Stent set|
|US5571153||Mar 25, 1996||Nov 5, 1996||Wallst+E,Acu E+Ee N; Hans I.||Device for hyperthermia treatment|
|US5578008||Oct 14, 1993||Nov 26, 1996||Japan Crescent, Inc.||Heated balloon catheter|
|US5588965||Mar 7, 1995||Dec 31, 1996||American Medical Systems, Inc.||Device for slowly dilating the prostatic urethra|
|US5609583||Sep 21, 1995||Mar 11, 1997||Hakki; A-Hamid I.||Collapsible catheter|
|US5624392||Aug 8, 1994||Apr 29, 1997||Saab; Mark A.||Heat transfer catheters and methods of making and using same|
|US5685847||Jul 27, 1995||Nov 11, 1997||Boston Scientific Corporation||Stent and therapeutic delivery system|
|US5718686||Jul 2, 1996||Feb 17, 1998||Urocath Corporation||Anchoring system and method for indwelling urethral catheter|
|US5766209||Feb 16, 1994||Jun 16, 1998||Devonec; Marian A.||Prosthesis intended for the treatment of a natural lumen or tract, in particular an endo-urethral prosthesis|
|US5785641||May 8, 1996||Jul 28, 1998||Urocath Corporation||Male indwelling urethral catheter sizing system and insertion method|
|US5843144||Jun 26, 1995||Dec 1, 1998||Urologix, Inc.||Method for treating benign prostatic hyperplasia with thermal therapy|
|US5876517||Oct 28, 1997||Mar 2, 1999||Atotech Deutschland Gmbh||Chromate-plating bath and process for finishing zinc zinc alloy or cadmium surfaces|
|US5916195||Feb 4, 1998||Jun 29, 1999||Argomed Ltd.||Internal catheter|
|DE895046C||Oct 2, 1948||Dec 7, 1953||Ulrich W Doering||Medizinisches Geraet zur Waermebehandlung innerer Organe und Einfuehrung in Koerperhoehlen|
|EP0105677B1||Sep 22, 1983||Dec 10, 1986||Kureha Kagaku Kogyo Kabushiki Kaisha||Endotract antenna device for hyperthermia|
|EP0341988B1||May 9, 1989||Jan 13, 1993||American Medical Systems, Inc.||Prostate balloon dilator|
|EP0449472B1||Mar 18, 1991||Dec 6, 1995||Argomed Ltd||An apparatus for localized thermal treatment of mammals|
|EP0543309B1||Nov 16, 1992||Nov 2, 1995||Engel, Konrad Dr.med.||Device for the treatment of male urinary incontinence|
|EP0672401B1||Mar 6, 1995||Sep 25, 2002||AGROMED Ltd.||Thermal treatment apparatus|
|EP0733379B1||Mar 20, 1996||Sep 1, 2004||ContiCare Medical, Inc.||Self-cleansing bladder drainage device|
|EP0753289B1||Jul 2, 1996||Nov 26, 2003||Marian Devonec||Fractionable catheter|
|EP0790041B1||Jul 17, 1996||May 6, 2004||Eckhard Dr. Alt||Implantable vascular and endoluminal stents|
|EP0801938B1||Apr 16, 1997||Jun 23, 2004||Wit IP Corporation||Thermal treatment apparatus|
|FR439636A||Title not available|
|FR774318A||Title not available|
|FR1328484A||Title not available|
|FR1550927A||Title not available|
|GB151004A||Title not available|
|GB287772A||Title not available|
|GB315971A||Title not available|
|GB317604A||Title not available|
|GB658662A||Title not available|
|GB1563795A||Title not available|
|JP1263440A||Title not available|
|JP6189330A||Title not available|
|JP6343661A||Title not available|
|JP52104397A||Title not available|
|JP60235940A||Title not available|
|JP62005045A||Title not available|
|JP63222759A||Title not available|
|JPS5616437B2||Title not available|
|1||Abstract, Kaver et al., "A New Transurethral Water-Induced Thermal (WIR) Dilation Device for the Treatment of BPH," presented at SIU, Sydney, Australia, Poster Session 26, BPH, Thermotherapy and Hypothermia (Sep. 1994).|
|2||European Search Report, Application No. EP 95 10 3189 dated Sep. 26, 1995.|
|3||European Search Report, Application No. EP 97 10 6282 dated Dec. 7, 1999.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6655934 *||Mar 20, 2002||Dec 2, 2003||Innovent, L.L.C.||Inverted peristaltic pumps and related methods|
|US6758857 *||Nov 13, 2001||Jul 6, 2004||Acmi Corporation||Treatment catheters with thermally insulated regions|
|US7306586||Dec 30, 2003||Dec 11, 2007||Opmi Funding Corporation||Continuous drainage adaptor|
|US7615046 *||Oct 25, 2006||Nov 10, 2009||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US7777130||Jun 18, 2007||Aug 17, 2010||Vivant Medical, Inc.||Microwave cable cooling|
|US8093500||Jun 14, 2010||Jan 10, 2012||Vivant Medical, Inc.||Microwave cable cooling|
|US8167870 *||Oct 1, 2009||May 1, 2012||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US20020082556 *||Nov 13, 2001||Jun 27, 2002||Iulian Cioanta||Treatment catheters with thermally insulated regions|
|US20040208764 *||Apr 15, 2004||Oct 21, 2004||Richard Wolf Gmbh||Medical tubing pump|
|US20050148999 *||Dec 30, 2003||Jul 7, 2005||Opmi Funding, Inc.||Continuous drainage adaptor|
|US20070005049 *||Jun 29, 2006||Jan 4, 2007||Comben Richard H||Apparatus and Method of Treating Urinary Incontinence by Heating Urethra|
|US20080172041 *||Oct 25, 2006||Jul 17, 2008||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US20100016839 *||Oct 1, 2009||Jan 21, 2010||Sobhy Shehata||Apparatus and method for the controlled hydrodistention of the urinary bladder|
|US20100243287 *||Jun 14, 2010||Sep 30, 2010||Vivant Medical, Inc.||Microwave Cable Cooling|
|US20110208180 *||Feb 25, 2010||Aug 25, 2011||Vivant Medical, Inc.||System and Method for Monitoring Ablation Size|
|EP1469201A2 *||Feb 11, 2004||Oct 20, 2004||Richard Wolf GmbH||Peristaltic pump for medical purposes|
|EP1469201A3 *||Feb 11, 2004||Jul 12, 2006||Richard Wolf GmbH||Peristaltic pump for medical purposes|
|EP1610739A2 *||Mar 16, 2004||Jan 4, 2006||Elmedical Ltd.||System and method for treating urinary tract disorders|
|EP1610739A4 *||Mar 16, 2004||Jun 20, 2007||Elmedical Ltd||System and method for treating urinary tract disorders|
|U.S. Classification||604/113, 604/97.01, 606/28, 604/153|
|International Classification||A61F2/958, A61B17/00, F04B43/12, A61F7/00, A61B17/22, A61F7/12, A61F7/02, A61B18/00, A61B18/08, F24H1/12|
|Cooperative Classification||A61B2018/00101, A61F2007/025, A61F2007/0095, A61F2007/0054, F04B43/1253, A61B18/08, A61M25/10, A61F7/12, A61B2018/00547, A61F7/123, A61B2018/00166, A61F2007/0086, A61B2017/00274, F24H1/121, A61B2017/22038|
|European Classification||A61B18/08, F24H1/12B, A61M25/10, F04B43/12G, A61F7/12, A61F7/12B|
|Dec 10, 2002||AS||Assignment|
Owner name: JPMORGAN CHASE BANK, AS ADMINISTRATIVE AGENT, NEW
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Year of fee payment: 8
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Owner name: WIT IP CORPORATION, MASSACHUSETTS
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Effective date: 20050721
|Mar 3, 2008||REMI||Maintenance fee reminder mailed|
|Aug 22, 2008||LAPS||Lapse for failure to pay maintenance fees|