|Publication number||USRE40768 E1|
|Application number||US 10/447,490|
|Publication date||Jun 23, 2009|
|Filing date||May 29, 2003|
|Priority date||Mar 1, 1999|
|Also published as||CA2289159A1, DE60045806D1, EP1033569A1, EP1033569B1, US6239445|
|Publication number||10447490, 447490, US RE40768 E1, US RE40768E1, US-E1-RE40768, USRE40768 E1, USRE40768E1|
|Original Assignee||Siemens Healthcare Diagnostics Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (12), Non-Patent Citations (3), Classifications (14), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates to an apparatus and method for performing tests on a sample of body fluid to be optically inspected.
It is useful for various medical diagnostic purposes to utilize a reflectance spectroscope to analyze samples of body fluid, for example, to determine the color of a person's urine. A conventional spectroscope may determine the color of a urine sample disposed on a white, non-reactive pad by illuminating the pad and taking a number of reflectance readings from the pad, each having a magnitude relating to a different wavelength of visible light. The color of the urine on the pad may then be determined based upon the relative magnitudes of red, green, blue and infrared reflectance signals.
Conventional spectroscopes may be used to perform a number of different urinalysis tests utilizing a reagent strip on which a number of different reagent pads are disposed. Each reagent pad may be provided with a different reagent which causes a color change in response to the presence of a certain type of constituent in urine, such as leukocytes (white blood cells) or red blood cells. Such a reagent strip may have ten or more different types of reagent pads.
In a conventional spectroscope, the process of inspecting a reagent strip may be performed by dipping the reagent strip in a urine sample, blotting excess urine from the reagent strip, placing the reagent strip at a designated location in the spectrophotometer, and pressing a start button which causes the spectroscope to begin automatic processing and inspection of the reagent strip.
It is an object of the invention to overcome the disadvantages of the prior art. This object is solved by a combination of features of the main claim. The sub-claims disclose further advantageous embodiments of the invention.
The summary of the invention does not necessarily describe all necessary features of the invention, and the invention may also reside in a sub-combination of described features. The “Summary of the Invention,” thus incorporated, presents, therefore, only an example, but not a limitation of the subject matter.
The invention is directed to an apparatus and method which allow different types of liquid carriers to be utilized in an optical inspection apparatus in a simple and convenient manner.
An apparatus in accordance with the invention is directed to an optical inspection apparatus adapted to inspect a liquid sample, such as a body fluid sample. The apparatus includes a tray that is adapted to be physically coupled to a first liquid sample carrier and a second liquid sample carrier, each of the first and second liquid sample carriers being adapted to hold a liquid sample. The first liquid sample carrier is of a first type and the second liquid sample carrier is of a second type different from the first type. The apparatus has a light source adapted to illuminate one of the liquid samples associated with one of the liquid sample carriers when the liquid sample carrier is coupled to the tray at an inspection location and a detector adapted to receive light from the liquid sample when the liquid sample is being illuminated by the light source.
The first liquid sample carrier may be in the form of a disposable reagent cassette, and the second liquid sample carrier may be adapted to support a reagent strip having a plurality of reagent pads disposed thereon, with the first liquid sample carrier having an elongated channel formed therein, the channel being sized to accommodate the reagent strip.
The invention is also directed to a method of using an optical inspection apparatus having a support tray that supports a liquid sample to be inspected, a light source that illuminates the liquid sample supported by the support tray when the support tray is at an inspection location, and a detector that detects light received from the liquid sample.
The method includes the steps of (a) placing onto the support tray a removable insert of a first type that carries a liquid sample, (b) causing the liquid sample to be illuminated by the light source, (c) causing light received from the liquid sample to be detected by the detector, (d) taking the removable insert off of the support tray, (e) placing onto the support tray a removable insert of a second type that carries a liquid sample, the second type of removable insert having a different physical structure from the first type of removable insert, (f) causing the liquid sample on the second type of removable insert to be illuminated by the light source, and (g) causing light received from the liquid sample to be detected by the detector.
The features and advantages of the present invention will be apparent to those of ordinary skill in the art in view of the detailed description of the preferred embodiment, which is made with reference to the drawings, a brief description of which is provided below.
The inspection apparatus 10 has a housing 17 with an opening 18 formed therein into which a support tray 20 may be retracted. Referring to
As shown in
As shown in
The reagent strip holder 40 has a central channel 43 formed therein which is sized to conform to the shape of a reagent strip 46 (FIG. 6). The reagent strip holder 40 may have a raised lip 44 which is disposed around The periphery of the reagent strip holder 40 to reduce the likelihood of body fluid samples contaminating the support tray 20.
When the support tray 20 is disposed so that either the reagent cassette 22 or the reagent strip holder 40 is disposed at an inspection location within the inspection apparatus 10, the controller 100 turns on a light source 108, which may be a light bulb or a light-emitting diode for example, via a switch 110 connected to the controller 100. The light source 108 may be turned on a period of time prior to the performance of an optical inspection so that it will be sufficiently warmed up. If the light source 108 is not needed to provide illumination within a period of time following a test, it may be turned off to conserve its life.
When the fluid sample in either the reagent cassette 22 or on the reagent strip holder 40 is illuminated by the light source 108, a detection apparatus 112 is used to detect light from the fluid sample. The detection apparatus 112 may be composed, for example, of a number of detectors disposed in a detector array, with each of the detectors generating a respective electrical reflectance signal which may be provided to a routing circuit in the form of a multiplexer 114, for example.
Each reflectance signal has a magnitude that depends on the amount of light detected by the associated detector. The controller 100 can selectively read any one of the reflectance signals by transmitting a select signal to the multiplexer 114. The multiplexer 114 then transmits the selected reflectance signal to an amplifier 116 and an analog-to-digital (A/D) converter 118, which transmits the binary signal corresponding to the analog reflectance signal output by the amplifier 116 to the controller 100.
The inspection apparatus 10 may be used to optically inspect multiple reagent cassettes 22 and multiple reagent strips 46 in any order desired by the user, since the reagent cassettes 22 and the reagent strip holder 40 have the same outer dimensions and fit within the recess 30 in the support tray 20.
In using the inspection apparatus 10, the user may prepare a reagent cassette 22 for optical inspection by putting a body fluid sample in the well 24 and then placing the cassette 22 in the recess 30 formed in the support tray 20. The user may then press a start button 14 on the keyboard 12 to cause the controller 100 to retract the support tray 20 inwardly so that the window 28 in the reagent cassette 22 is illuminated by the light source 108 and so that one or more reflectance signals are generated by the detection apparatus 112. After the reflectance signals are generated and processed by the controller 100, the test results may be displayed on the display 16 (
In order to then perform one or more optical inspection tests on a reagent strip 46, the user would remove the reagent cassette 22 from the recess 30 in the support tray, discard the cassette 22, and place the reagent strip holder 40 in the recess 30 in the support tray 20.
To prepare a reagent strip 46 for optical inspection, the user would dip the reagent strip 46 into a body fluid sample to be tested so that the reagent pads 50 are immersed in the sample or otherwise apply the sample to the pads 50. After the side of the reagent strip 46 is blotted to remove excess fluid, the user places the strip 46 in the central channel 43 of the holder 40 and presses the start key 14 to initiate optical inspection of the reagent strip 46. The reagent strip holder 40 is then automatically retracted into the housing 17 and may be successively positioned at multiple locations within the inspection apparatus 10 so that each of the reagent pads 50 is optically inspected at an inspection location.
The provision of a support table 20 which is adapted to be used with different types of liquid carriers allows the user to quickly and conveniently change the liquid carrier while allowing the inspection apparatus to optically inspect different types of liquid-carrying mechanisms. It should be noted that the support tray 20 does not have to be removed from the inspection apparatus 10 in order to replace one type of liquid carrier with another type of liquid carrier.
Modifications of the inspection apparatus 10 will be apparent to those of ordinary skill in the art. For example, instead of providing the support tray 20 with the recess 30, the support tray 20 could be adapted to be physically coupled to each of the liquid carriers 22, 40 in alternative ways.
Numerous further modifications and alternative embodiments of the invention will be apparent to those skilled in the art in view of the foregoing description. This description is to be construed as illustrative only, and is for the purpose of teaching those skilled in the art the best mode of carrying out the invention. The details of the structure and methods may be varied substantially without departing from the spirit of the invention, and the exclusive use of all modifications which come within the scope of the appended claims is reserved.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3907503 *||Jan 21, 1974||Sep 23, 1975||Miles Lab||Test system|
|US4689702 *||Apr 12, 1984||Aug 25, 1987||Fuji Photo Film Co., Ltd.||Magnetic tape cassette|
|US5059394 *||Feb 11, 1988||Oct 22, 1991||Lifescan, Inc.||Analytical device for the automated determination of analytes in fluids|
|US5231576 *||Sep 7, 1990||Jul 27, 1993||Terumo Kabushiki Kaisha||Measuring apparatus|
|US5661563 *||May 9, 1996||Aug 26, 1997||Bayer Corporation||Reflectance spectroscope with read head for minimizing singly-reflected light rays|
|US5945341 *||Oct 21, 1996||Aug 31, 1999||Bayer Corporation||System for the optical identification of coding on a diagnostic test strip|
|US5955028 *||Aug 14, 1997||Sep 21, 1999||Caliper Technologies Corp.||Analytical system and method|
|EP0806662B1||Apr 28, 1997||Oct 27, 2004||Bayer Corporation||Apparatus and method for determination of urine color|
|EP0871033A2||Mar 12, 1998||Oct 14, 1998||LRE Technology Partner GmbH||Test strip package and measuring apparatus for using the same|
|EP1130383B1||Apr 15, 1994||Sep 15, 2004||Boehringer Mannheim Gmbh||Diskette with circular arranged test elements|
|WO1983000926A1||Aug 26, 1982||Mar 17, 1983||Clark, Stanley||Reflectance meter|
|WO2000022406A2||Oct 12, 1999||Apr 20, 2000||Matallana Kielmann Ina||Method and device for analyzing reactive strips|
|1||*||Clinitek 50 User's Guide, 1996 Bayer Corporation, Revised Mar. 1996, 18 pages.|
|2||European Office Action, Application No. : 00103322.4-1524, Date Mailed: Feb. 14, 2007.|
|3||*||Howard, W. E. III, An Introduction to Reflectance Spectroscopy for Dry Phase Reagent Chemistry, Miles Science Journal, pp. 33-37.|
|U.S. Classification||250/576, 250/573, 356/440, 422/566|
|International Classification||G01N21/78, G01N1/10, G01J3/46, G01N21/27, G01N21/86, G01N21/01, G01N21/00, G01N21/49|
|Jan 19, 2009||AS||Assignment|
Owner name: BAYER HEALTHCARE LLC, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAYER CORPORATION;REEL/FRAME:022123/0585
Effective date: 20030101
Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC., NEW YORK
Free format text: CHANGE OF NAME;ASSIGNOR:SIEMENS MEDICAL SOLUTIONS DIAGNOSTICS;REEL/FRAME:022123/0689
Effective date: 20071220
Owner name: SIEMENS MEDICAL SOLUTIONS DIAGNOSTICS, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BAYER HEALTHCARE LLC;REEL/FRAME:022123/0608
Effective date: 20070102
|Nov 6, 2012||FPAY||Fee payment|
Year of fee payment: 12