|Publication number||USRE42480 E1|
|Application number||US 10/017,611|
|Publication date||Jun 21, 2011|
|Filing date||Dec 14, 2001|
|Priority date||Nov 14, 1994|
|Also published as||CA2202453A1, CA2202453C, DE69725932D1, DE69725932T2, EP0820740A1, EP0820740B1, EP1166725A2, EP1166725A3, EP1166725B1, US5674296, US5865846, US6001130, US6156067, US20040098131, USRE42576|
|Publication number||017611, 10017611, US RE42480 E1, US RE42480E1, US-E1-RE42480, USRE42480 E1, USRE42480E1|
|Inventors||Vincent Bryan, Alex Kunzler|
|Original Assignee||Warsaw Orthopedic, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (135), Non-Patent Citations (28), Referenced by (5), Classifications (77), Legal Events (3) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Human spinal disc prothesis with hinges
US RE42480 E1
The invention relates to a spinal disc endoprosthesis. The endoprosthesis has a resilient body formed of one or more materials which may vary in stiffness from a relatively stiff exterior annular gasket portion to a relatively supple central nucleus portion. Concaval-convex elements at least partly surround that nucleus portion so as to retain the nucleus portion and gasket between adjacent vertebral bodies in a patient's spine. Assemblies of endoprosthetic discs, endoprosthetic vertebral bodies, and endoprosthetic longitudinal ligaments may be constructed. To implant this endoprosthesis assembly, information is obtained regarding the size, shape, and nature of a patient's damaged spine. Thereafter, one or more prosthetic vertebral bodies and disc units are constructed in conformity with that information. Finally, the completed and conformed vertebral body and disc assembly is implanted in the patient's spine.
1. A vertebral An intervertebral disc endoprosthesis, comprising a resilient body formed of materials varying in stiffness from a relatively stiff exterior portion to a relatively supple central portion; and concaval-convex elements at least partly surrounding the resilient body for retaining said resilient body in a position between the concaval-convex elements, and wherein said concaval-convex elements each comprise generally L-shaped supports, each support having a first concaval-convex leg, the first leg having an outer convex surface for engaging adjacent bone and a corresponding inner concave surface for retaining the resilient body, each support further having a second leg extending generally perpendicularly to the first leg and adapted for affixation to adjacent bone structures.
2. A vertebral An intervertebral disc endoprosthesis according to claim 1 wherein said resilient body comprises an annular gasket and a nuclear central portion.
3. A vertebral An intervertebral disc endoprosthesis according to claim 2 wherein the gasket extends about the nuclear central portion to enclose it within a thin layer.
4. A vertebral An intervertebral disc endoprosthesis according to claim 3 wherein the gasket, and the nuclear central portion, and the thin layer are molded together as one piece.
5. A vertebral An intervertebral disc endoprosthesis according to claim 1 further comprising cannulated screw means for attaching the concaval-convex element supports to adjacent bone structure.
6. A vertebral An intervertebral disc endoprosthesis according to claim 5 wherein said cannulated screw means comprises a screw, and a screw anchor seatable within bone structure and adapted to threadably receive the screw.
7. A vertebral An intervertebral disc endoprosthesis according to claim 6 wherein the screws terminate in the anchor.
8. A vertebral An intervertebral disc endoprosthesis according to claim 6 wherein the anchor has an open end and the screw proceeds through the open end of the anchor and terminates in the bone of the vertebral body.
9. A vertebral An intervertebral disc endoprosthesis according to claim 1 further comprising a seal member attached to the concaval-convex elements and surrounding said resilient body.
10. A vertebral An intervertebral disc endoprosthesis according to claim 9 wherein said seal member comprises a flexible sheet material having a multiplicity of pores, the pores being from about 5 microns to about 60 microns in size.
11. A vertebral An intervertebral disc endoprosthesis according to claim 10 further including sealing means applied to said flexible sheet material to render said flexible sheet material substantially impervious to the passage of any fluid.
12. A vertebral An intervertebral disc endoprosthesis according to claim 11 wherein the sealing means is silicone.
13. A vertebral An intervertebral disc endoprosthesis according to claim 9 wherein said concaval-convex elements and said seal member collectively surround said resilient body with a watertight seal.
14. A vertebral An intervertebral disc endoprosthesis according to claim 2 wherein said annular gasket is relatively stiff and said nuclear central portion is relatively supple.
15. A vertebral An intervertebral disc endoprosthesis according to claim 1 wherein at least one of the second legs is hingedly attached to the respective first concaval-convex leg.
16. A vertebral An intervertebral disc endoprosthesis, comprising a resilient body formed of materials varying in stiffness from a relatively stiff exterior portion to a relatively supple central portion; and concaval-convex elements at least partly surrounding the resilient body between adjacent vertebral bodies for retaining the resilient body between adjacent vertebral bodies in a patient's spine, and wherein said concaval-convex elements each comprise generally L-shaped supports, each support having a first concaval-convex leg, the first leg having an outer convex surface for engaging adjacent bone and a corresponding inner concave surface for retaining the resilient body, each support further having a second leg extending generally perpendicularly to the first leg and adapted for affixation to adjacent bone structure, wherein at least the second leg is constructed of titanium.
17. A vertebral An intervertebral disc endoprosthesis comprising a resilient nucleus, first and second rigid concaval-convex elements at least partly surrounding the nucleus, first and second legs formed, respectively, with the first and second rigid concaval-convex elements, first and second means for affixing the respective legs to vertebral bodies adjacent the concaval-convex elements and nucleus, longitudinal ligament prosthesis means extending between the legs of the first and second concaval-convex elements to inhibit undesirable motion of the vertebral bodies relative to one another, and biodegradable washers positioned between the ligament prosthesis means and the respective legs.
18. A vertebral An intervertebral disc endoprosthesis comprising a rounded, resilient nucleus body convex on all surfaces and concaval-convex elements, each concaval-convex element being of relatively constant cross-sectional thickness and having an outer convex surface for engaging adjacent bone structure which has been milled to mate with the concaval-convex element outer convex surface, and a corresponding inner concave surface for engaging the rounded resilient body, wherein lubricant is provided between the nucleus body and the concaval-convex elements.
19. A vertebral An intervertebral endoprosthesis comprising an integral disc unit, said unit including a pair of confronting L-shaped supports having concaval-convex shapes in given legs, a resilient body interposed between the supports, and a flexible seal extending from one support to the other and sealing the resilient body within the supports inside a substantially watertight compartment, further comprising a plurality of said integral disc units.
20. The vertebral intervertebral disc endoprosthesis according to claim 19 wherein each support includes a groove about its circumference.
21. The intervertebral disc endoprosthesis according to claim 13, wherein the seal member comprises a flexible sheet secured to each of the concaval-convex elements.
22. The intervertebral disc endoprosthesis according to claim 19, further comprising a plurality of said integral disc units.
This is a continuation-in-part of U.S. patent application Ser. No. 08/681,230, filed Jul. 22, 1996, now U.S. Pat. No. 5,674,296 and which is a continuation-in-part of U.S. patent application Ser. No. 08/339,490, filed Nov. 14, 1994, which is abandoned.
BACKGROUND OF THE INVENTION
This invention relates generally to human prostheses, and especially to spinal column vertebral intervertebral disc prostheses. The invention also relates to surgical procedures for preparing the patient to receive a vertebral an intervertebral disc endoprosthesis, and for implanting that endoprosthesis in the patient's spine.
The herniation of a spinal disc and the often resultant symptoms of intractable pain, weakness, sensory loss, incontinence and progressive arthritis are among the most common of debilitating processes affecting mankind. If a patient's condition does not improve after conservative treatment, and if clear physical evidence of nerve root or spinal cord compression is apparent, and if correlating radiographic studies (i.e., MRI or CT imaging or myelography) confirm the condition, surgical removal of the herniated disc may be indicated. The process of discectomy—as the name implies—involves the simple removal of the disc without attempt to replace or repair the malfunctioning unit. In the United States in 1985, over 250,000 such operations were performed in the lumbar spine and in the cervical spine.
Statistics suggest that present surgical techniques are likely to result in short-term relief, but will not prevent the progressive deterioration of the patient's condition in the long run. Through better pre-operative procedures and diagnostic studies, long-term patient results have improved somewhat. But it has become clear that unless the removed disc is replaced or the spine is otherwise properly supported, further degeneration of the patient's condition will almost certainly occur.
In the mid-1950's and 60's, Cloward and Smith & Robinson popularized anterior surgical approaches to the cervical spine for the treatment of cervical degenerative disc disease and related disorders of the vertebrae, spinal cord and nerve root; these surgeries involved disc removal followed by interbody fusion with a bone graft. It was noted by Robinson (Robinson, R. A.: The Results of Anterior Interbody Fusion of the Cervical Spine, J. Bone Joint Surg., 440A: 1569-1586, 1962) that after surgical fusion, osteophyte (bone spur) reabsorption at the fused segment might take place. However, it has become increasingly apparent that unfused vertebral segments at the levels above and below the fused segment degenerate at accelerated rates as a direct result of this fusion. This has led some surgeons to perform discectomy alone, without fusion, by a posterior approach in the neck of some patients. However, as has occurred in surgeries involving the lower back where discectomy without fusion is more common as the initial treatment for disc herniation syndromes, progressive degeneration at the level of disc excision is the rule rather than the exception. Premature degenerative disc disease at the level above and below the excised disc can and does occur.
Spine surgery occasionally involves fusion of the spine segments. In addition to the problems created by disc herniation, traumatic, malignant, infectious and degenerative syndromes of the spine can be treated by fusion. Other procedures can include bone grafts and heavy duty metallic rods, hooks, plates and screws being appended to the patient's anatomy; often they are rigidly and internally fixed. None provide for a patient's return to near-normal functioning. Though these procedures may solve a short-term problem, they can cause other, longer term, problems.
A number of attempts have been made to solve some of the problems described above by providing a patient with spinal disc prostheses, or artificial discs of one sort or another. For example, Steffee, U.S. Pat. No. 5,031,437, describes a spinal disc prosthesis having upper and lower rigid flat plates and a flat elastomeric core sandwiched between the plates. Frey et al., U.S. Pat. Nos. 4,917,704 and 4,955,908, disclose intervertebral prostheses, but the prostheses are described as solid bodies.
U.S. Pat. Nos. 4,911,718 and 5,171,281 disclose resilient disc spacers, but no inter-connective or containing planes or like elements are suggested, and sealing the entire unit is not taught.
It is the primary aim of the present invention to provide a vertebral an intervertebral disc endoprosthesis which will perform effectively and efficiently within a patient's spine over a long period of time, and which will not encourage degeneration of or cause damage to adjacent natural disc parts.
It is a related objective to provide a new vertebral intervertebral disc endoprosthesis surgical procedure which will decrease post-operative recovery time and inhibit post-operative disc, vertebral body and spinal joint degeneration.
It is yet another object to provide a method of installing the endoprosthesis so as to accurately mate the endoprosthesis with an adjacent specifically formed bone surface. An associated object is to provide an endoprosthesis which will encourage bone attachment to, and growth upon, adjacent outer surfaces of the endoprosthesis.
Yet another object is to provide a vertebral endoprosthesis in which the parts are non-oncogenic.
Still another object is to provide a vertebral an intervertebral disc endoprosthesis having a resilient element to accommodate shocks and other forces applied to the spine.
Another object is to provide a highly effective vertebral endoprosthesis which includes several disc endoprostheses and one or more prosthetic vertebral bodies. A related object is to provide these elements in a pre-assembled array for implantation in a patient.
SUMMARY OF THE INVENTION
To accomplish these objects, the invention comprises a resilient body formed of a material varying in stiffness from a relatively stiff exterior portion to a relatively supple central portion. A concaval-convex means at least partly surrounds that resilient body so as to retain the resilient body between adjacent vertebral bodies of a patient's spine. If medical considerations so indicate, several disc endoprostheses can be combined with one or more endoprosthetic vertebral bodies in an entire assembly.
To implant this endoprosthesis assembly, information is obtained regarding the size, shape, and nature of a patient's damaged natural spinal discs. If one or more of the patient's vertebral bodies also require replacement, information about those bodies is also obtained. Thereafter, one or more prosthetic disc units and interposed prosthetic vertebral body units are constructed and preassembled in conformity with that information. Finally, the completed and conformed prosthetic disc and vertebral body assembly is implanted in the patient's spine.
Other objects and advantages of the invention will become apparent upon reading the following detailed description and upon reference to the drawings. Throughout the drawings, like reference numerals refer to like parts.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a fragmentary vertical view of a portion of a human spine in which is installed a novel vertebral disc endoprosthesis embodying the present invention;
FIG. 2 is a fragmentary side elevational view similar to FIG. 1 showing the elements of a patient's spine and having a novel vertebral disc endoprosthesis embodying the present invention installed therein;
FIG. 3 is a sectional view taken substantially in the plane of line 3-3 in FIG. 1;
FIG. 4 is an exploded view of the novel vertebral disc endoprosthesis;
FIG. 5 is a vertical fragmentary view of a patient's spine similar to FIG. 1, but showing a series of novel disc endoprosthesis units installed in the spine and interconnected to one another;
FIG. 6 is a fragmentary sectional view of a patient's spine similar to FIG. 3 and taken along line 6-6 in FIG. 5, but showing a natural upper vertebral body, and upper endoprosthetic disc; an adjacent endoprosthetic vertebral body; a second or lower endoprosthetic disc; and a second or lower natural vertebral body;
FIG. 7 is a sectional view taken substantially in the plane of line 7-7 of FIG. 6;
FIG. 8 is a fragmentary side elevational view of the assembly shown in FIG. 6; and
FIG. 9 is a fragment vertical view, similar to FIG. 1, of a portion of a human spine in which is installed a variant form of the novel vertebral disc endoprosthesis the variant form having a prosthetic longitudinal ligament;
FIG. 10 is a sectional view taken substantially in the plane of line 10-10 in FIG. 9;
FIG. 11 is a top view of a retainer means for use with a vertebral disc endoprosthesis;
FIG. 12 is a sectional view taken substantially in the plane of line 12-12 of FIG. 11;
FIG. 13 is a side view of a vertebral disc endoprosthesis having a groove for receiving the retainer means; and
FIG. 14 is a cross-sectional view of the retainer means in use.
While the invention will be described in connection with a preferred embodiment and procedure, it will be understood that it is not intended to limit the invention to this embodiment or procedure. On the contrary, it is intended to cover all alternatives, modifications, and equivalents as may be included within the spirit and scope of the invention as defined by the appended claims.
Turning more specifically to FIGS. 1-3, a portion of a human spine 10 is shown. The illustrated spine 10 has been subjected to a discectomy surgical process. To discourage degeneration of or damage to the natural vertebral bodies 12 and 14 and their respective facet joints, in accordance with the invention, a vertebral an intervertebral disc endoprosthesis 18 is affixed between the adjacent natural vertebral bodies 12 and 14. Here this vertebral intervertebral disc endoprosthesis 18 comprises a resilient disc body 20 having a relatively stiff annular gasket exterior portion 22 and a relatively supple nuclear central portion 24. The annular gasket 22 can be formed from a suitable biocompatible elastomer in the range of approximately 70-90 durometer hardness and the nuclear central portion 24 can be formed from a softer biocompatible elastomeric polymer of approximately 30 durometer hardness. In an alternate embodiment, the gasket 22 can extend over and under the nuclear central portion 24 so as to fully enclose it within a thin layer. In a further embodiment, the nuclear central portion, the gasket, and the thin layer extension are molded together to form one piece having different durometer hardnesses.
Concaval-convex means 30 surround the resilient body 20 to retain the resilient body 20 between the adjacent natural vertebral bodies 12, 14 in a patient's spine 10. To this end, as shown in FIG. 3, the concaval-convex means 30 comprise two generally L-shaped supports 32 and 34. The supports 32, 34 each have confronting first concaval-convex legs 42, 44, each leg being of relatively constant cross-sectional thickness. Each leg 42, 44 has an outer convex surface 52, 54 for engaging the adjacent bone of the natural vertebral bodies 12, 14. Corresponding inner concave surfaces 62, 64 in confronting array retain the resilient body 20 in its illustrated compressive force shock-absorbing position. These supports 32 and 34 can undergo principle movement away from one another, but only limited secondary translational, rotational and distractional motion will occur. Each support 32, 34 has a second wing or leg 72, 74 extending generally perpendicularly to the first legs 42, 44 respectively, and adapted for affixation to the adjacent bone structure. To carry out aspects of the invention described below, this affixation is effectively accomplished by cannulated screw devices 82, 84 which may be of a biodegradable type manufactured by Zimmer of Largo, Fla. Each device 82, 84 comprises a screw 92, 94; and a screw anchor 102, 104 adapted to threadably receive the screw extends radially into and seats within the bone structure 12, 14 as especially shown in FIG. 3. The screws 92, 94 may terminate in the anchor or alternately proceed through an open ended anchor and terminate in the bone of the vertebral body 12, 14 directly. The anchors 102, 104 may be close-ended, open ended, or of the expansion type.
To discourage and prohibit migration of fluids between the endoprosthesis 18 and adjacent parts of the anatomy, a seal member 110 is attached to the supports 32, 34 so as to surround the resilient body 20 which is comprised of the gasket 22 and nucleus 24, in accordance with another aspect of the invention. Here, this seal member 110 comprises a flexible sheet material having a multiplicity of pores. Preferably, the pores are from about 5 microns to about 60 microns in size. A flexible, strong polymer sheet material from which this seal is formed can be a Kevlar-like material, or it can be Goretex-like material, expanded PTFE, or other appropriate biocompatible material, such as polyether, polyurethane, or polycarbonate urethane membranes, can be used. Kevlar material is offered by the E. I. DuPont de Nemours Company of Wilmington, Del. and Goretex material is offered by the W. T. Gore Company of Flagstaff and Phoenix, Ariz. The seal material may be lined on its interior surface, its exterior surface, or both surfaces with silicone or any suitable sealing material so as to render the flexible sheet material substantially impervious to the passage of any fluid. A watertight seal is perfected when the seal 110 is glued or otherwise affixed to the legs 42, 44 and mediate portions of the legs 72, 74 as suggested in FIGS. 1-3.
In the space beneath the seal member 110 and between the disc body 20 and the concave surfaces of legs 42, 44, a lubricant may be used. The lubricant used may be saline or an appropriate liquid or particulate material lubricant.
In an alternative embodiment, the watertight seal between the endoprosthesis 18 and adjacent parts of the anatomy can be provided by developing a groove 402 completely encircling the periphery of each of the legs 42, 44. In this embodiment, the legs 72, 74 may be attached to the circumferential groove member 402 by laser-welding or other suitable means. If the legs 72, 74 are of polymeric material, they may be attached by mechanical or adhesive techniques. Only one of the grooves is shown in FIG. 13. In this embodiment, the seal member 410 is provided with a beaded edge 412 for each groove. Additionally, a retaining band 415 is provided for each groove to retain the seal member 410 in groove 402. The retaining bands 415 can be in the form of a biocompatible monofilament wire of, for example, stainless steel or titanium, a synthetic polymer cable or a braided wire cable. As shown in FIG. 11, each retaining band is crimped anteriorly by a crimping sleeve 420. Of course, more than one crimping sleeve may be used, if necessary. Alternately, the retaining band is fastened by laser-welding. Although one sealing arrangement consisting of the groove, beaded edge and retaining band is shown in FIG. 14, it should be understood that the sealing arrangement on the concaval-convex leg of the other support is identical in design and function.
In use, the seal member 410 is placed about the concaval-convex means 30. The retaining bands 415 are then placed adjacent to the respective groove 402 and crimped anteriorly, thereby fitting the bands into the grooves. Each beaded edge 412 prevents the slipping of the seal member underneath the retaining band. Thus, the retaining band, the groove and the beaded edge all cooperate to provide a water-tight seal to prevent the migration of fluids between the endoprosthesis 18 and adjacent parts of the anatomy. Glue can also be used to affix the seal member to the concaval-convex means 30 as a supplemental means for perfecting the seal.
In a first embodiment, the first legs 42, 44 are formed as an integral piece with the respective second wings or legs 72, 74. In the alternate embodiment of FIG. 3, however, the first legs 42, 44 are hingedly attached to the respective second legs 72, 74. A hinge 43, 73 is provided at the point from which the second leg 72, 74 extends generally perpendicularly to the first leg 42, 44. The hinge is not intended to function as such after being installed, but only during installation so as to allow better alignment of the endoprosthesis with the biologically variable anterior surface of the respective vertebral body. Once the endoprosthesis is installed and affixed via the screw devices, the hinge will no longer move.
These hinges 43, 73 may take any of the several known forms. Each hinge can be a rod and socket hinge, a pin type hinge, or a slip joint fitting, or it can be a web or a membrane type hinge of metal or plastic.
The second wings or legs 72, 74 may be made of a suitable metal such as titanium or a polymeric material. Alternately, each leg 72, 74 including its associated hinge element, can be made of a biodegradable polymeric material. When the legs 72, 74 are made of biodegradable material, the screws 92, 94 used for affixing the legs to the adjacent bone structure may be of the standard shoulder screw type in order to maintain firm fixation to the screw anchors 102, 104 after biodegradation of the legs 72, 74.
Legs 72, 74 can be of a thin construction that allows some degree of flexibility so as to promote a better mating of the legs to the anterior aspect of the vertebral body 12, 14.
The legs can have a central closed oblong slot to accommodate a screw or other fixation device. Should a second endoprosthesis device be placed at an adjoining level, the leg 72, 74 would be placed on top of the corresponding leg from the adjacent device. The screw 92, 94 or other fixation device would then pass through the closed oblong slot of the overlapping legs 72, 74.
In accordance with another aspect of the invention, the supports 32, 34 are formed of a biocompatible metal which may contain chromium cobalt or titanium. Surface roughening or titanium beading 112, 114 on the exterior surfaces 52, 54 of legs 42, 44 encourages positive bonding between the adjacent bone and the convex surfaces 52, 54. Over time, bone fuses or grows into the surface roughening, thereby adhering to the legs 42, 44 in a rigid and strong manner.
As suggested in FIGS. 9 and 10, a prosthetic longitudinal ligament 250 can be connected between the screws 92, 94 to limit motions between elements of the spine 10 in the area where the endoprosthesis 18 is implanted. This strap 250 may be made of the Kevlar-like material or the Goretex-like material described above, or it may be made of any other strong biocompatible material. The ligament 250 may also be considered a spacer or cover for providing some degree of separation between overlying soft tissues in the body and the anterior-most surfaces of the device. However, it is not designed for restricting or preventing motion in the disc body. A biodegradable washer can be provided around the screws 92, 94 at a point between the strap 250 and the respective wing or leg 72, 74. When biodegradable washers are used, the screws 92, 94 used for affixing the legs to the adjacent bone structure may be of the standard shoulder screw type in order to maintain firm fixation to the screw anchors 102, 104 after biodegradation of the washers.
When a ligament is used in the embodiment of the device having hinged legs 92, 94, the prosthetic longitudinal ligament structure can comprise several parallel bands of material separated by approximately 10 mm.
In accordance with another aspect of the invention, multiple endoprosthetic disc units can be placed in series with a straddling interlock appendage providing stability and fixation as shown in FIG. 5. Entire portions of a patient's spine can be replaced by a series of interconnected endoprosthetic vertebral bodies and endoprosthetic disc units. FIGS. 6-8 show an upper natural vertebral body unit 312 to which an upper endoprosthetic body 308 has been attached. A lower natural vertebral body 314 has attached, at its upper end, an endoprosthetic disc unit 318. Between these endoprosthetic disc units 308 and 318 is an endoprosthetic vertebral body 320. As suggested by FIG. 7, the endoprosthetic vertebral body 320 need not be irregularly shaped in cross sectional aspect; rather, manufacturing processes may suggest that it have a circular cross-sectional shape. As show in FIGS. 6 and 8, this endoprosthetic vertebral body 320 comprises a titanium element 321, to which are attached the preformed upper and lower endoprosthetic vertebral body upper and lower concaval-convex elements 322, 324. Each concaval-convex element 322, 324 is attached to the prosthetic vertebral body 320, as shown in FIG. 7, by extending set screws 330 through the titanium vertebral body 321 into a stem-like projection 331 extending from each of the concaval-convex elements 322, 324. A hole 360 in the body 320 accommodates the stem-like projections 331 of the concaval-convex elements 322 and 324. The stem-like projection 331 of the concaval-convex elements 322 and 324 is used only in conjunction with a prosthetic vertebral body implant construction 320.
An ear 340 is affixed, as by weldments 341, to a leg 342 extending from a concaval-convex element 322 as illustrated in FIGS. 6 and 8. An anchor 352 can be threaded into the endoprosthetic vertebral body 320, and a screw 362 can be turned into the anchor 352 so as to rigidly assemble the leg 342 to a leg 354 extending from the lower endoprosthetic disc unit 318.
In an alternate embodiment, ear 340 could be replaced with a biodegradable washer around each of the screws 92, 94 at a point located between the strap 250 and the respective leg 72, 74. (FIG. 10.) The washer could be of a size to overlie and fix in place the interlocking wing leg from the adjacent intervertebral disc space. Alternately, ear 340 (FIG. 8.) may be eliminated in favor of screws 92, 94 having a head of increased diameter so that the screw head engages and fixes both the slotted leg 72, 74 and the interlocking tongue leg.
The upper disc endoprosthesis 308, the endoprosthetic vertebral body 320, and the lower disc endoprosthesis 318 can all be assembled and interconnected as a unit before implantation in a patient's body when indicated.
As also suggested in FIG. 6, the annular corners 372, 374 of natural vertebral bodies 312, 314 each can extend irregularly radially outwardly of the adjacent disc endoprosthesis 308, 318. However, the corners 382B, 384B of the prosthetic vertebral body 320 do not generally extend significantly outside those disc units 308, 318, thus discouraging vertebral body engagement with and consequent abrasion or other damage to adjacent portions of the patient's natural anatomy. Preferably the endoprosthetic vertebral body 320 is not exactly right cylindrical in shape, but is rather slightly biconical; that is, the endoprosthetic vertebral body 320 has a waist 390 of minimum radius R at an axial medial point as suggested in FIG. 6.
According to yet another aspect of the invention, novel surgical procedures permit effective and permanent installation of the endoprosthetic vertebral body 320 and associated parts. First, a surgeon or medical technician develops information about the size, shape and nature of a patient's damaged vertebral body or bodies from radiographs, CT and/or MRI scans, noting specifically the anterior-posterior and lateral dimensions of the end plate of each involved vertebral body and the vertical height of the anterior aspect of each involved vertebral and/or proximate vertebral body and vertical height of the mid portion of involved and proximate relatively normal intervertebral disc spaces. This information is transmitted by telephone, computer datalink or documentary transport to a specialized laboratory. That laboratory constructs one or more prosthetic assemblies of the sort shown in FIG. 6 in conformity with the received information and this disclosure. Each of the assemblies can include a prosthetic vertebral body 321, and at each body end is a prosthetic disc 308, 318. Each prosthetic disc unit comprises, in turn, the concaval-convex elements 30; the resilient body 20 interposed between the concaval-convex elements; and the seal unit 110 secured around the interior legs and resilient body. Thereafter, the completed and conformed assembly is implanted in the patient's spine 10.
When the unit or units have been received and the patient properly prepared, the damaged natural spinal disc or discs and vertebral body or bodies are removed and the adjacent spinal bone surfaces are milled or otherwise formed to provide concave surfaces to receive the confronting convex surfaces 52, 54. Thereafter, the disc units and vertebral body are installed in the patient's spine.
To accurately locate the concaval-convex surfaces in the patient's spine, holes 382A, 384A (FIG. 3) are precisely located and then formed in the bone structure using a measuring instrument centered in the evacuated natural intravertebral intervertebral disc space. These holes are then tapped to form female threads therein. When the threads have been formed, the anchors 102, 104 are implanted in the respective tapped holes, thereby creating an imaginary platform of reference points located precisely with respect to the patient's spine. After the holes have been formed and the anchors 102, 104 implanted, a bone surface milling jig (not shown) is affixed to the anchors 102, 104 and the desired concave surfaces of predetermined shape are formed on the inferior and superior surfaces of the opposing vertebral bodies using one of a selection of predetermined milling head or bit sizes. Thereafter, the bone milling jig is removed and the concaval-convex elements 52, 54 identical in shape to the milled surfaces 112, 114 are inserted between the distracted milled vertebral bodies 12, 14. The distraction device is then moved. The concaval-convex structures are then attached by the same anchors 102, 104 to the bone, thus insuring a precise and stable mate between the bone surfaces and the convex surfaces 52, 54.
If necessary, a damaged implanted nucleus and/or gasket 24 can be removed and replaced. This can be accomplished by slitting the seal 110; removing the annular gasket 24 and damaged nucleus 22, and replacing them with new, undamaged elements. Thereafter, the seal 110 can be re-established by suturing or gluing closed the slit seal.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2677369 *||Mar 26, 1952||May 4, 1954||Fred L Knowles||Apparatus for treatment of the spinal column|
|US3486505||May 22, 1967||Dec 30, 1969||Gordon M Morrison||Orthopedic surgical instrument|
|US3875595||Apr 15, 1974||Apr 8, 1975||Froning Edward C||Intervertebral disc prosthesis and instruments for locating same|
|US3876728||Mar 16, 1973||Apr 8, 1975||Hodogaya Chemical Co Ltd||Urethane resins from tolylene diisocyanate distillation residues active hydrogen containing compounds and vinyl monomers|
|US4023572||Aug 5, 1975||May 17, 1977||Hanfried Weigand||Milling tool for preparing a joint socket in the prosthetic replacement of a joint|
|US4116200||Oct 1, 1976||Sep 26, 1978||Aesculap-Werke Aktiengesellschaft Vormals Jetter & Scheerer||Milling tool for surgical purposes|
|US4179810||Oct 27, 1977||Dec 25, 1979||Axel Kirsch||Device for milling slots in a jawbone for mounting an endossal device|
|US4309777 *||Nov 13, 1980||Jan 12, 1982||Patil Arun A||Artificial intervertebral disc|
|US4349921||Jun 16, 1980||Sep 21, 1982||Kuntz J David||Intervertebral disc prosthesis|
|US4599086 *||Jun 7, 1985||Jul 8, 1986||Doty James R||Spine stabilization device and method|
|US4645507||Sep 3, 1985||Feb 24, 1987||Gmt Gesellschaft Fur Medizinische Technik Mbh||Prosthesis|
|US4714469||Feb 26, 1987||Dec 22, 1987||Pfizer Hospital Products Group, Inc.||Spinal implant|
|US4743256||Jan 22, 1987||May 10, 1988||Brantigan John W||Surgical prosthetic implant facilitating vertebral interbody fusion and method|
|US4757983||Aug 20, 1986||Jul 19, 1988||Charles D. Ray, Ltd.||Head and chin for face-down operations|
|US4759766 *||Sep 9, 1987||Jul 26, 1988||Humboldt-Universitaet Zu Berlin||Intervertebral disc endoprosthesis|
|US4759769 *||Jun 22, 1987||Jul 26, 1988||Health & Research Services Inc.||Artificial spinal disc|
|US4766328||May 26, 1987||Aug 23, 1988||System-General Corporation||Programmable pulse generator|
|US4777942||Sep 24, 1987||Oct 18, 1988||Sulzer Brothers Limited||Bone milling instrument|
|US4800639||Jun 12, 1987||Jan 31, 1989||Sulzer Brothers Limited||Method of making a metal bone implant|
|US4834757||Mar 28, 1988||May 30, 1989||Brantigan John W||Prosthetic implant|
|US4863476||Aug 28, 1987||Sep 5, 1989||Shepperd John A N||Spinal implant|
|US4863477||May 12, 1987||Sep 5, 1989||Monson Gary L||Synthetic intervertebral disc prosthesis|
|US4874389||Dec 7, 1987||Oct 17, 1989||Downey Ernest L||Replacement disc|
|US4878915||Jan 4, 1989||Nov 7, 1989||Brantigan John W||Surgical prosthetic implant facilitating vertebral interbody fusion|
|US4887595||Jul 29, 1987||Dec 19, 1989||Acromed Corporation||Surgically implantable device for spinal columns|
|US4904260||Jul 25, 1988||Feb 27, 1990||Cedar Surgical, Inc.||Prosthetic disc containing therapeutic material|
|US4904261||Aug 4, 1988||Feb 27, 1990||A. W. Showell (Surgicraft) Limited||Spinal implants|
|US4908032||Mar 2, 1988||Mar 13, 1990||Waldemar Link Gmbh & Co.||Reconstruction prosthesis|
|US4908036||May 31, 1988||Mar 13, 1990||Waldemar Link Gmbh & Co.||Endoprosthesis|
|US4911718 *||Jun 10, 1988||Mar 27, 1990||University Of Medicine & Dentistry Of N.J.||Functional and biocompatible intervertebral disc spacer|
|US4917704 *||Jun 8, 1988||Apr 17, 1990||Sulzer Brothers Limited||Intervertebral prosthesis|
|US4932969 *||Dec 17, 1987||Jun 12, 1990||Sulzer Brothers Limited||Joint endoprosthesis|
|US4932975||Oct 16, 1989||Jun 12, 1990||Vanderbilt University||Vertebral prosthesis|
|US4946378||Nov 22, 1988||Aug 7, 1990||Asahi Kogaku Kogyo Kabushiki Kaisha||Artificial intervertebral disc|
|US4955908 *||Jun 8, 1988||Sep 11, 1990||Sulzer Brothers Limited||Metallic intervertebral prosthesis|
|US4978355||Jan 6, 1986||Dec 18, 1990||Sulzer Brothers Limited||Plastic bone implant having a reinforced contact surface|
|US4997432 *||Mar 14, 1989||Mar 5, 1991||Waldemar Link Gmbh & Co.||Surgical instrument set|
|US5002576 *||Jun 6, 1989||Mar 26, 1991||Mecron Medizinische Produkte Gmbh||Intervertebral disk endoprosthesis|
|US5015247||Jun 13, 1988||May 14, 1991||Michelson Gary K||Threaded spinal implant|
|US5035716||May 10, 1990||Jul 30, 1991||Downey Ernest L||Replacement disc|
|US5047055||Dec 21, 1990||Sep 10, 1991||Pfizer Hospital Products Group, Inc.||Hydrogel intervertebral disc nucleus|
|US5059193||Apr 19, 1990||Oct 22, 1991||Spine-Tech, Inc.||Expandable spinal implant and surgical method|
|US5059194||Feb 12, 1990||Oct 22, 1991||Michelson Gary K||Cervical distractor|
|US5062845||May 10, 1989||Nov 5, 1991||Spine-Tech, Inc.||Method of making an intervertebral reamer|
|US5071437 *||Nov 21, 1990||Dec 10, 1991||Acromed Corporation||Artificial disc|
|US5080662||Nov 27, 1989||Jan 14, 1992||Paul Kamaljit S||Spinal stereotaxic device and method|
|US5084048||Jun 29, 1990||Jan 28, 1992||Sulzer Brothers Limited||Implant for vertebrae with spinal stabilizer|
|US5108438||May 7, 1990||Apr 28, 1992||Regen Corporation||Prosthetic intervertebral disc|
|US5122130 *||Oct 25, 1990||Jun 16, 1992||Waldemar Link Gmbh & Co.||Forceps for inserting intervertebral device|
|US5123926||Feb 22, 1991||Jun 23, 1992||Madhavan Pisharodi||Artificial spinal prosthesis|
|US5171280||Mar 21, 1991||Dec 15, 1992||Sulzer Brothers Limited||Intervertebral prosthesis|
|US5171281 *||Oct 9, 1991||Dec 15, 1992||University Of Medicine & Dentistry Of New Jersey||Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness|
|US5176708||Feb 28, 1991||Jan 5, 1993||Sulzer Brothers Limited||Prosthetic implant|
|US5192326 *||Sep 9, 1991||Mar 9, 1993||Pfizer Hospital Products Group, Inc.||Hydrogel bead intervertebral disc nucleus|
|US5192327||Mar 22, 1991||Mar 9, 1993||Brantigan John W||Surgical prosthetic implant for vertebrae|
|US5234431 *||Apr 2, 1992||Aug 10, 1993||Waldemar Link Gmbh & Co.||Bone plate arrangement|
|US5236460||Oct 10, 1991||Aug 17, 1993||Midas Rex Pneumatic Tools, Inc.||Vertebral body prosthesis|
|US5258031 *||Dec 14, 1992||Nov 2, 1993||Danek Medical||Intervertebral disk arthroplasty|
|US5261911 *||Jul 9, 1992||Nov 16, 1993||Allen Carl||Anterolateral spinal fixation system|
|US5261913||Aug 25, 1992||Nov 16, 1993||J.B.S. Limited Company||Device for straightening, securing, compressing and elongating the spinal column|
|US5306307 *||Jul 22, 1991||Apr 26, 1994||Calcitek, Inc.||Spinal disk implant|
|US5306308 *||Oct 23, 1990||Apr 26, 1994||Ulrich Gross||Intervertebral implant|
|US5314477 *||Mar 4, 1991||May 24, 1994||J.B.S. Limited Company||Prosthesis for intervertebral discs and instruments for implanting it|
|US5314478||Apr 26, 1991||May 24, 1994||Kyocera Corporation||Artificial bone connection prosthesis|
|US5320644||Jul 30, 1992||Jun 14, 1994||Sulzer Brothers Limited||Intervertebral disk prosthesis|
|US5370697 *||Feb 19, 1993||Dec 6, 1994||Sulzer Medizinaltechnik Ag||Artificial intervertebral disk member|
|US5383933||Nov 26, 1992||Jan 24, 1995||Waldemar Link Gmbh & Co.||Endoprosthesis|
|US5401269 *||Mar 10, 1993||Mar 28, 1995||Waldemar Link Gmbh & Co.||Intervertebral disc endoprosthesis|
|US5403314||Feb 5, 1993||Apr 4, 1995||Acromed Corporation||Apparatus for retaining spinal elements in a desired spatial relationship|
|US5425772||Sep 20, 1993||Jun 20, 1995||Brantigan; John W.||Prosthetic implant for intervertebral spinal fusion|
|US5425773||Apr 5, 1994||Jun 20, 1995||Danek Medical, Inc.||Intervertebral disk arthroplasty device|
|US5443514||Oct 1, 1993||Aug 22, 1995||Acromed Corporation||Method for using spinal implants|
|US5456719||Sep 18, 1992||Oct 10, 1995||Waldemar Link Gmbh & Co||Endoprosthesis with a prosthesis part made of viscoelastic synthetic resin|
|US5458638||Nov 6, 1992||Oct 17, 1995||Spine-Tech, Inc.||Non-threaded spinal implant|
|US5458642 *||Jan 18, 1994||Oct 17, 1995||Beer; John C.||Synthetic intervertebral disc|
|US5484437||Jun 10, 1993||Jan 16, 1996||Michelson; Gary K.||Apparatus and method of inserting spinal implants|
|US5489307||Sep 1, 1994||Feb 6, 1996||Spine-Tech, Inc.||Spinal stabilization surgical method|
|US5489308||Sep 1, 1994||Feb 6, 1996||Spine-Tech, Inc.||Spinal implant|
|US5496318||Aug 18, 1993||Mar 5, 1996||Advanced Spine Fixation Systems, Inc.||Interspinous segmental spine fixation device|
|US5507816||Dec 1, 1992||Apr 16, 1996||Customflex Limited||Spinal vertebrae implants|
|US5514180||Jan 14, 1994||May 7, 1996||Heggeness; Michael H.||Prosthetic intervertebral devices|
|US5527315||Oct 18, 1994||Jun 18, 1996||Jbs S.A.||Spinal osteosynthesis rod with three branches|
|US5534028||Apr 20, 1993||Jul 9, 1996||Howmedica, Inc.||Hydrogel intervertebral disc nucleus with diminished lateral bulging|
|US5534029 *||Dec 1, 1993||Jul 9, 1996||Yumiko Shima||Articulated vertebral body spacer|
|US5545229||Jul 28, 1993||Aug 13, 1996||University Of Medicine And Dentistry Of Nj||Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness|
|US5556431 *||Aug 9, 1994||Sep 17, 1996||B+E,Uml U+Ee Ttner-Janz; Karin||Intervertebral disc endoprosthesis|
|US5562738||Jan 12, 1995||Oct 8, 1996||Danek Medical, Inc.||Intervertebral disk arthroplasty device|
|US5575815 *||Oct 6, 1993||Nov 19, 1996||Endoluminal Therapeutics, Inc.||Local polymeric gel therapy|
|US5593409||Feb 17, 1995||Jan 14, 1997||Sofamor Danek Group, Inc.||Interbody spinal fusion implants|
|US5609636||Jan 11, 1996||Mar 11, 1997||Spine-Tech, Inc.||Spinal implant|
|US5645598||Apr 15, 1996||Jul 8, 1997||Smith & Nephew, Inc.||Spinal fusion device with porous material|
|US5649926||Jun 6, 1995||Jul 22, 1997||Advanced Spine Fixation Systems, Inc.||Spinal segmental reduction derotational fixation system|
|US5658285||Oct 27, 1995||Aug 19, 1997||Jbs S.A.||Rehabitable connecting-screw device for a bone joint, intended in particular for stabilizing at least two vertebrae|
|US5662158||Jun 2, 1995||Sep 2, 1997||Johnson & Johnson Professional, Inc.||Self-lubricating implantable articulation member|
|US5674294 *||Sep 14, 1994||Oct 7, 1997||Commissariat A L'energie Atomique||Intervertebral disk prosthesis|
|US5674295||Apr 26, 1996||Oct 7, 1997||Raymedica, Inc.||Prosthetic spinal disc nucleus|
|US5674296 *||Jul 22, 1996||Oct 7, 1997||Spinal Dynamics Corporation||Human spinal disc prosthesis|
|US5683464||Jun 7, 1995||Nov 4, 1997||Sulzer Calcitek Inc.||Spinal disk implantation kit|
|US5702450||Jun 27, 1994||Dec 30, 1997||Bisserie; Michel||Intervertebral disk prosthesis|
|US5713899||Apr 26, 1996||Feb 3, 1998||Societe Jbs Sa||Cervical cage designed for the performance of intersomatic arthrodesis|
|US5716415||Mar 8, 1996||Feb 10, 1998||Acromed Corporation||Spinal implant|
|US5720748||Jun 7, 1995||Feb 24, 1998||Spine-Tech, Inc.||Spinal stabilization surgical apparatus|
|US5722977||Jan 24, 1996||Mar 3, 1998||Danek Medical, Inc.||Method and means for anterior lumbar exact cut with quadrilateral osteotome and precision guide/spacer|
|US5723013||Feb 6, 1996||Mar 3, 1998||Jbs S.A.||Spacer implant for substituting missing vertebrae|
|US5741253||Oct 29, 1992||Apr 21, 1998||Michelson; Gary Karlin||Method for inserting spinal implants|
|US5782830||Jul 10, 1996||Jul 21, 1998||Sdgi Holdings, Inc.||Implant insertion device|
|US5782832||Oct 1, 1996||Jul 21, 1998||Surgical Dynamics, Inc.||Spinal fusion implant and method of insertion thereof|
|US5797909||Jun 7, 1995||Aug 25, 1998||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US5824093||Jun 6, 1997||Oct 20, 1998||Raymedica, Inc.||Prosthetic spinal disc nucleus|
|US5824094||Oct 17, 1997||Oct 20, 1998||Acromed Corporation||Spinal disc|
|US5865846||May 15, 1997||Feb 2, 1999||Bryan; Vincent||Human spinal disc prosthesis|
|US5865848||Sep 12, 1997||Feb 2, 1999||Artifex, Ltd.||Dynamic intervertebral spacer and method of use|
|US5885300||Mar 31, 1997||Mar 23, 1999||Asahi Kogaku Kogyo Kabushiki Kaisha||Guide apparatus of intervertebral implant|
|US5888197||Jul 1, 1997||Mar 30, 1999||Thompson Surgical Instruments, Inc.||Cam-operated universal latch joint apparatus|
|US5888226||Nov 12, 1997||Mar 30, 1999||Rogozinski; Chaim||Intervertebral prosthetic disc|
|US5897087||Jun 7, 1995||Apr 27, 1999||Thompson Surgical Instruments, Inc.||CAM tightened universal joint clamp|
|US5899942 *||May 15, 1998||May 4, 1999||W. L. Gore & Associates, Inc.||Apparatus and method for protecting prosthetic joint assembly from wear deris|
|US5902233||Dec 13, 1996||May 11, 1999||Thompson Surgical Instruments, Inc.||Angling surgical retractor apparatus and method of retracting anatomy|
|US5928284||Jul 9, 1998||Jul 27, 1999||Mehdizadeh; Hamid M.||Disc replacement prosthesis|
|US5947971||Nov 21, 1996||Sep 7, 1999||Sulzer Spine-Tech Inc.||Spinal stabilization surgical apparatus|
|US5976187||Oct 6, 1997||Nov 2, 1999||Spinal Innovations, L.L.C.||Fusion implant|
|US5984865||Sep 15, 1998||Nov 16, 1999||Thompson Surgical Instruments, Inc.||Surgical retractor having locking interchangeable blades|
|US5989291||Feb 26, 1998||Nov 23, 1999||Third Millennium Engineering, Llc||Intervertebral spacer device|
|US6001130||Oct 6, 1997||Dec 14, 1999||Bryan; Vincent||Human spinal disc prosthesis with hinges|
|US6017008||Jan 19, 1999||Jan 25, 2000||Thompson Surgical Instruments, Inc.||Cam tightened universal joint clamp|
|US6022376||Mar 16, 1998||Feb 8, 2000||Raymedica, Inc.||Percutaneous prosthetic spinal disc nucleus and method of manufacture|
|US6033363||Jan 26, 1999||Mar 7, 2000||Thompson Surgical Instruments||Insulating sleeve for a table mounted retractor|
|US6059790||Jul 16, 1998||May 9, 2000||Sulzer Spine-Tech Inc.||Apparatus and method for spinal stabilization|
|US6059829||Mar 8, 1995||May 9, 2000||Synthese||Intervertebral implant|
|DE2263842A1 *||Dec 28, 1972||Jul 4, 1974||Hoffmann Daimler Siegfried Dr||Bandscheibenprothese|
|DE3023353A1 *||Jun 21, 1980||Apr 9, 1981||Sulzer Ag||Zwischenwirbel-totalprothese|
|EP0176728A1 *||Aug 17, 1985||Apr 9, 1986||Humboldt-Universitšt zu Berlin||Intervertebral-disc prosthesis|
|EP0560140A1 *||Feb 25, 1993||Sep 15, 1993||Waldemar Link (GmbH & Co.)||Intervertebral disc endoprosthesis|
|SU895433A1 *|| ||Title not available|
|SU1560184A1 *|| ||Title not available|
|1|| *||"Artificial Disc Replacement;" Enker et al; Spine; vol. 18; No. 8; 1993; pp. 1061-1070.|
|2|| *||"Biomechanics of the SB Charite Lumbar Intervertebral Disc Endoprosthesis;" Buttner-Janz et al; International Orthopaedics; vol. 13; 1989; pp. 173-176.|
|3|| *||"Cervical Disc Disease;" Simeone and Rothman; Pennsylvania Hospital & University of Pennsylvania; 1975;pp. 387-433.|
|4|| *||"Design of an Intervertebral Disc Prothesis;" Hedman et al; Spine; vol. 17; No. 6; 1991; pp. S256-S260.|
|5|| *||"Development of a Prosthetic Intervertebral Disc;" Lee et al; Spine; vol. 16; No. 6; 1991; pp. S253-5255.|
|6|| *||"Failed Back Surgery Syndrome;" Long; Neurosurgery Clinics of North America; vol. 2, No. 4; Oct. 1991; pp. 899-919.|
|7|| *||"Far Lateral Lumbar Disc Herniations;" Hodd; Neurosurgery Clinics of North America; vol. 4, No. 1; Jan. 1993; pp. 117-124.|
|8|| *||"Finite-Element Modeling of the Synthetic Intervertebral Disc;" Langrana et al; Spine; vol. 16; No. 6; 1991; pp. S245-S252.|
|9|| *||"Lumbar Intervertebral Disc Prosthesis;" Tie-sheng et al; Chinese Medical Journal, 104-(5); 1991; pp. 381-386.|
|10|| *||"Metal Cementless Prosthesis for Vertebral Body Replacement of Metastatic Malignant Disease of the Cervical Spine;" Solini et al; Journal of Spinal Disorders; vol. 2; No. 4; 1989; pp. 254-262.|
|11|| *||"Natural History & Prognosis of Cervical Spondylosis;" Lees et al,; British Medical Journal; Dec. 28, 1963; British Medical Association, London, England; Copyright 1963; pp. 1607-1610.|
|12|| *||"Protesi Somatica Cervicale;" Solini et al; Ingegneria Ricostruttiva D'Avanguardia; Howmedica International; Pfizer; Italy.|
|13|| *||"Shear Stability of an Elastomeric Disc Spacer Within an Intervertebral Joint: A Parametric Study;" Hawkins et al; Journal of Biomechanical Enginnering Technical Briefs; vol. 114; Aug. 1992; pp. 414-415.|
|14|| *||"Some Additional Suggestions for an Intervertebral Disc Prosthesis;" Edeland; Dept. of Occupational Health; Vdvo PV AB; S40508; Goteborg; Sweden; 1985 Butterworth & Co. Publishers Ltd.|
|15|| *||"The Artificial Disc-Introduction, History and Socioeconomics;" Ray; Clinical Efficacy and Outcome in the Diagnosis and Treatment of Low Back Pain; Raven Press, Ltd.; NY; 1992; pp. 205-280.|
|16|| *||"The Neurological Manifestations of Cervical Spondylosis;" Brain et al; Brain, Journal of Neurology; vol. 75; MacMillan & Co.; 1952; pp. 187-225.|
|17|| *||"The Ocurrence of Optic Neuritis in Lesions of the Spinal Cord, Injury, Tumor, Melitis;" Taylor, Collier, Brain: A Journal of Neurology; vol. 24; MacMillian & Co. Ltd., 1901; pp. 532-550.|
|18|| *||"The Results of Anterior Interbody Fusion of the Cervical Spine;" Robinson et al; The Journal of Bone & Joint Surgery; vol. 44-A, No. 8, Dec. 1962; pp. 1569-1587.|
|19|| *||"Wear Studies for Development of an Intervertebral Disc Prosthesis;" Hellier et al; Spine; vol. 17; No. 6; 1989; pp. S86-S96.|
|20|| *||"The Artificial Disc—Introduction, History and Socioeconomics;" Ray; Clinical Efficacy and Outcome in the Diagnosis and Treatment of Low Back Pain; Raven Press, Ltd.; NY; 1992; pp. 205-280.|
|21||Artificial Disc, Market Potential and Technology Update, Viscogliosi Bros., LLC, Feb. 2000, pp. 1-65.|
|22||Boning-Up, The Musculoskeletal Healthcare Industry, Industry Commentary & Review of 1999, Viscogliosi Bros., LLC, Mar. 10, 2000, pp. 1-33.|
|23||Bryan Total Cervical Disc Prosthesis, Single Level Surgical Technique Manual, SPINALdynamics Corporation, 2000, 01080-004, pp. 29.|
|24||International Search Report-PCT/US01/24791.|
|25||International Search Report—PCT/US01/24791.|
|26||Morphology of the Human Skeleton, pp. 268270; 283-291; 315-331; 489-495.|
|27||Spine Industry Dynamics, Viscogliosi Bros., LLC, Mar. 10, 2000, pp. 1-4.|
|28|| *||Wear Studies for Development of an Intervertebral Disc Prosthesis; Hellier et al; Spine; vol. 17; No. 6 Supplement; 1992; pp. S86-S96.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US8292954 *||Sep 10, 2010||Oct 23, 2012||Articulinx, Inc.||Disc-based orthopedic devices|
|US8764830||Oct 19, 2012||Jul 1, 2014||Articulinx, Inc.||Disc-shaped orthopedic devices|
|US20110224790 *||Sep 10, 2010||Sep 15, 2011||Articulinx, Inc.||Disc-based orthopedic devices|
|US20120123547 *||Jan 14, 2010||May 17, 2012||Ulrich Holzwarth||Intervertebral disc strain-relief support|
|US20140058521 *||Oct 30, 2013||Feb 27, 2014||Neuropro Technologies, Inc.||Bone fusion device|
| || |
|U.S. Classification||623/17.16, 606/247, 623/17.11, 623/17.13|
|International Classification||A61F2/44, A61B17/70, A61F2/30, A61B17/00, A61F2/00, A61F2/08, A61B17/68, A61B17/86|
|Cooperative Classification||Y10S606/91, Y10S606/907, A61F2002/30772, A61B2017/00004, A61F2002/30663, A61F2002/30235, A61F2220/0033, A61F2002/30579, A61F2002/30016, A61F2002/30069, A61F2002/449, A61F2002/30474, A61F2002/30599, A61F2002/30451, A61F2/44, A61F2310/00023, A61F2230/0076, A61F2250/0019, A61F2230/0067, A61F2230/0043, A61B17/86, A61F2220/0058, A61F2002/30448, A61F2002/30405, A61F2310/00029, A61F2002/30576, A61F2/30742, A61F2002/30495, A61F2220/0041, A61F2250/0063, A61F2/4425, A61B17/686, A61F2/30771, A61F2002/30624, A61F2002/30785, A61F2002/30578, A61F2002/30507, A61F2220/005, A61B17/7059, A61F2002/3038, A61F2002/30464, A61F2002/302, A61F2002/443, A61F2002/30433, A61F2220/0075, A61F2002/30168, A61F2002/30253, A61F2/08, A61F2002/30594, A61F2002/30113, A61F2230/0069, A61F2002/30487, A61F2/442, A61F2002/30563, A61F2002/30469, A61F2230/0065, A61F2220/0025, A61F2230/0006, A61F2002/30461, A61F2002/30214|
|European Classification||A61F2/30B8, A61F2/44D2, A61F2/44D, A61F2/44, A61B17/68P|
|Feb 26, 2007||AS||Assignment|
Free format text: MERGER;ASSIGNORS:SDGI HOLDINGS, INC.;SOFAMOR DANEK HOLDINGS, INC.;REEL/FRAME:018929/0479
Owner name: WARSAW ORTHOPEDIC, INC., INDIANA
Effective date: 20060428
|Feb 2, 2005||AS||Assignment|
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MEDTRONIC SOFAMOR DANEK, INC.;REEL/FRAME:015635/0232
Owner name: SDGI HOLDINGS, INC., DELAWARE
Effective date: 20050128
Effective date: 20050128
Owner name: SDGI HOLDINGS, INC., DELAWARE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MEDTRONIC SOFAMOR DANEK, INC.;REEL/FRAME:015635/0232
|Jan 29, 2003||AS||Assignment|
Free format text: MERGER AND CHANGE OF NAME;ASSIGNOR:SPINAL DYNAMICS CORPORATION;REEL/FRAME:013669/0543
Owner name: MEDTRONIC SOFAMOR DANEK, INC., TENNESSEE
Effective date: 20021011
Free format text: MERGER AND CHANGE OF NAME;ASSIGNOR:SPINAL DYNAMICS CORPORATION;REEL/FRAME:013669/0543
Effective date: 20021011
Owner name: MEDTRONIC SOFAMOR DANEK, INC., TENNESSEE