|Publication number||USRE42753 E1|
|Application number||US 12/497,517|
|Publication date||Sep 27, 2011|
|Filing date||Jul 2, 2009|
|Priority date||Jun 7, 1995|
|Also published as||US6931268, USRE44875|
|Publication number||12497517, 497517, US RE42753 E1, US RE42753E1, US-E1-RE42753, USRE42753 E1, USRE42753E1|
|Inventors||Esmaiel Kiani-Azarbayjany, Mohamed Kheir Diab, James M. Lepper, Jr.|
|Original Assignee||Masimo Laboratories, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (191), Non-Patent Citations (11), Referenced by (168), Classifications (15), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Notice: More than one reissue application has been filed for the reissue of U.S. Pat. No. 7,239,905. The reissue applications are application Ser. No. 12/497,517 (the present application) and Ser. No. 13/047,740 (continuation of present application), both of which are reissues of U.S. Pat. No. 7,239,905.
This application is a continuation of U.S. patent application Ser. No. 09/706,965, filed Nov. 6, 2000, now U.S. Pat. No. 6,931,268, issued Aug. 16, 2005, which is a continuation of U.S. patent application Ser. No. 09/190,719, filed Nov. 12, 1998, now U.S. Pat. No. 6,151,516, issued Nov. 21, 2000, which is a continuation of U.S. patent application Ser. No. 08/843,863, filed Apr. 17, 1997, now U.S. Pat. No. 5,860,919, issued Jan. 19, 1999, which is a continuation of U.S. patent application Ser. No. 08/482,071, filed Jun. 7, 1995, now U.S. Pat. No. 5,638,816, issued Jun. 17, 1997. The present application incorporates the foregoing disclosures herein by reference.
1. Field of the Invention
The present invention relates to noninvasive systems for monitoring blood glucose and other difficult to detect blood constituent concentrations, such as therapeutic drugs, drugs of abuse, carboxyhemoglobin, Methemoglobin, cholesterol.
2. Description of the Related Art
In the past, many systems have been developed for monitoring blood characteristics. For example, devices have been developed which are capable of determining such blood characteristics as blood oxygenation, glucose concentration, and other blood characteristics. However, significant difficulties have been encountered when attempting to determine blood glucose concentration accurately using noninvasive blood monitoring systems such as by means of spectroscopic measurement.
The difficulty in determining blood glucose concentration accurately may be attributed to several causes. One of the significant causes is that blood glucose is typically found in very low concentrations within the bloodstream (e.g., on the order of 100 to 1,000 times lower than hemoglobin) so that such low concentrations are difficult to detect noninvasively, and require a very high signal-to-noise ratio. Additionally, with spectroscopic methods, the optical characteristics of glucose are very similar to those of water which is found in a very high concentration within the blood. Thus, where optical monitoring systems are used, the optical characteristics of water tend to obscure the characteristics of optical signals due to glucose within the bloodstream. Furthermore, since each individual has tissue, bone and unique blood properties, each measurement typically requires calibration for the particular individual.
In an attempt to accurately measure blood glucose levels within the bloodstream, several methods have been used. For example, one method involves drawing blood from the patient and separating the glucose from the other constituents within the blood. Although fairly accurate, this method requires drawing the patient's blood, which is less desirable than noninvasive techniques, especially for patients such as small children or anemic patients. Furthermore, when blood glucose monitoring is used to control the blood glucose level, blood must be drawn three to six times per day, which may be both physically and psychologically traumatic for a patient. Other methods contemplate determining blood glucose concentration by means of urinalysis or some other method which involves pumping or diffusing body fluid from the body through vessel walls or using other body fluids such as tears or sweat. However, such an analysis tends to be less accurate than a direct measurement of glucose within the blood, since the urine, or other body fluid, has passed through the kidneys (or skin in the case of sweat). This problem is especially pronounced in diabetics. Furthermore, acquiring urine and other body fluid samples is often inconvenient.
As is well known in the art, different molecules, typically referred to as constituents, contained within the medium have different optical characteristics so that they are more or less absorbent at different wavelengths of light. Thus, by analyzing the characteristics of the fleshy medium containing blood at different wavelengths, an indication of the composition of the blood in the fleshy medium may be determined.
Spectroscopic analysis is based in part upon the Beer-Lambert law of optical characteristics for different elements. Briefly, Beer-Lambert's law states that the optical intensity of light through any medium comprising a single substance is proportional to the exponent of the product of path length through the medium times the concentration of the substance within the medium times the extinction coefficient of the substance. That is,
where pl represents the path length through the medium, c represents the concentration of the substance within, the medium, ε represents the absorbtion (extinction) coefficient of the substance and lo is the initial intensity of the light from the light source. For optical media which have several constituents, the optical intensity of the light received from the illuminated medium is proportional to the exponent of the path length through the medium times the concentration of the first substance times the optical absorption coefficient associated with the first substance, plus the path length times the concentration of the second substance times the optical absorption coefficient associated with the second substance, etc. That is,
where εn represents the optical absorption (extinction) coefficient of the nth constituent and cn represents the concentration of the nth constituent.
Due to the parameters required by the Beer-Lambert law, the difficulties in detecting glucose concentration arise from the difficulty in determining the exact path length through a medium (resulting from transforming the multi-path signal to an equivalent single-path signal), as well as difficulties encountered due to low signal strength resultant from a low concentration of blood glucose. Path length through a medium such as a fingertip or earlobe is very difficult to determine, because not only are optical wavelengths absorbed differently by the fleshy medium, but also the signals are scattered within the medium and transmitted through different paths. Furthermore, as indicated by the above equation (2), the measured signal intensity at a given wavelength does not vary linearly with respect to the path length. Therefore, variations in path length of multiple paths of light through the medium do not result in a linear averaging of the multiple path lengths. Thus, it is often very difficult to determine an exact path length through a fingertip or earlobe for each wavelength.
In conventional spectroscopic blood constituent measurements, such a blood oxygen saturation, light is transmitted at various wavelengths through the fleshy medium. The fleshy medium (containing blood) attenuates the incident light and the detected signal can be used to calculate certain saturation values. In conventional spectroscopic blood constituent measurements, the heart beat provides a minimal modulation to the detected attenuated signal in order to allow a computation based upon the AC portion of the detected signal with respect to the DC portion of the detected signal, as disclosed in U.S. Pat. No. 4,407,290. This AC/DC operation normalizes the signal and accounts for variations in the pathlengths, as well understood in the art.
However, the natural heart beat generally provides approximately a 1-10% modulation (AC portion of the total signal) of the detected signal when light is transmitted through a patient's digit or the like. That is, the variation in attenuation of the signal due to blood may be only 1% of the total attenuation (other attenuation being due to muscle, bone, flesh, etc.). In fact, diabetes patients typically have even lower modulation (e.g., 0.01-0.1%). Therefore, the attenuation variation (AC portion of the total attenuation) due to natural pulse can be extremely small. In addition, the portion of the pulse modulation which is due to glucose is roughly only 9% of the pulse (approximately 1/11) at a wavelength of 1330-1340 nm where glucose absorbs effectively. Furthermore, to resolve glucose from 5 mg/dl to 1005 mg/dl in increments or steps of 5 mg/dl, requires resolution of 1/200 of the 9% of the modulation which is due to glucose. Accordingly, by way of three different examples—one for a healthy individual, one for a diabetic with a strong pulse, and one for a diabetic with a weak pulse—for absorption at 1330 nm, the system would require resolution as follows.
Required Total Resolution is product of a-c: 1/100* 1/11* 1/200= 1/220,000
Required total resolution is product of a-c: 1/100* 1/11* 1/200= 1/220,000
Required total resolution is product of a-c: 1/10,000* 1/11* 1/200= 1/220,000
As seen from the above three examples which provide the range of modulation typically expected among human patients, the total resolution requirements range from 1 in 220,000 to 1 in 22,000,000 in order to detect the attenuation which is due to glucose based on the natural pulse for the three examples. This is such a small portion that accurate measurement is very difficult. In most cases, the noises accounts for a greater portion of the AC portion (natural modulation due to pulse) of the signal than the glucose, leaving glucose undetectable. Even with state of the art noise reduction processing as described in U.S. patent application Ser. No. 08/249,690, filed May 26, 1994, now U.S. Pat. No. 5,482,036, signals may be resolved to a level of approximately 1/250,000. This is for an 18-bit system. With a 16-bit system, resolution is approximately 1/65,000. In addition, LEDs are often noisy such that even if resolution in the system is available to 1/250,000, the noise from the LEDs leave glucose undetectable.
To overcome these obstacles, it has been determined that by actively inducing a change in the flow of blood in the medium under test such that the blood flow varies in a controlled manner periodically, modulation can be obtained such that the portion of the attenuated signal due to blood becomes a greater portion of the total signal than with modulation due to the natural pulse. This leads to the portion of total attenuation due to glucose in the blood being a greater portion of the total signal. In addition, the signal can be normalized to account for factors such as source brightness, detector responsiveness, tissue or bone variation. Changes in blood flow can be induced in several ways, such as physically perturbing the medium under test or changing the temperature of the medium under test. In the present embodiment, by actively inducing a pulse, a 10% modulation in attenuation ( 1/10 of the total attenuation) is obtained, regardless of the patient's natural pulse modulation (whether or not the patient is diabetic). Accordingly, at 1330 nm with actively induced changes in blood flow, the resolution required is 1/10* 1/11* 1/200 or 1/22,000 (where 1/10 is the active pulse attenuation modulation (the modulation obtained by induced blood flow changes), 1/11 is the portion of the modulation due to glucose, and 1/200 the resolution required to obtain glucose in 5 mg/dl increments from 5-1005 mg/dl). As will be understood from the discussion above, such resolution can be obtained, even in a 16 bit system. In addition, the resolution is obtainable beyond the noise floor, as described herein.
In conventional blood constituent measurement through spectroscopy, perturbation of the medium under test has been avoided because oxygen (the most commonly desired parameter) is not evenly dispersed in the arterial and venous blood. Therefore, perturbation obscures the ability to determine the arterial oxygen saturation because that venous and arterial blood become intermingled. However, glucose is evenly dispersed in blood fluids, so the mixing of venous and arterial blood and interstitial fluids should have no significant effect on the glucose measurements. It should be appreciated that this technique will be effective for any substance evenly dispersed in the body fluids (e.g., blood, interstitial fluids, etc.).
One aspect of the present invention involves a system for non-invasively monitoring a blood constituent concentration in a living subject. The system comprises a light source which emits radiation at a plurality of wavelengths and an active pulse inducement device which, independent of the natural flow of blood in the fleshy medium, causes a periodic change in the volume of blood in the fleshy medium. An optical detector positioned to detect light which has propagated through the fleshy medium is configured to generate an output signal indicative of the intensity of the radiation after attenuation through the fleshy medium. A signal processor responds to the output signal to analyze the output signal to extract portions of the signal due to optical characteristics of the blood to determine the concentration of the constituent within the subject's bloodstream.
In one embodiment, of the system further comprises a receptacle which receives the fleshy medium, the receptacle further having an inflatable bladder.
In one embodiment, the system has a temperature variation element in the receptacle, the temperature variation element varies (e.g., increases) the temperature of the fleshy medium in order to induce a change (e.g., increase) in the flow of blood in the fleshy medium.
Another aspect of the present invention involves a system for non-invasively monitoring blood glucose concentration within a patient's bloodstream. A light source emits optical radiation at a plurality of frequencies, and a sensor receives a fleshy medium of the patient, the fleshy medium having flowing blood. A fluid (e.g., blood and interstitial fluids) volume change inducement device causes a cyclic change in the volume of blood in the fleshy medium. An optical detector positioned to receive the optical radiation after transmission through a portion of the fleshy medium responds to the detection of the optical radiation to generate an output signal indicative of the intensity of the optical radiation. A signal processor coupled to the detector receives the output signal, and responds to the output signal to generate a value representative of the glucose concentration in the blood of the patient.
Yet another aspect of the present invention involves a method of non-invasively determining a concentration of a blood constituent. The method comprises a plurality of steps. Optical radiation is transmitted through a medium having flowing fluid, wherein the fluid has a concentration of the fluid constituent. A periodic change in the volume of the fluid in the medium is actively induced. The optical optical radiation after transmission through at least a portion of the medium is detected and a signal indicative of the optical characteristics of the medium is generated. The signal is analyzed to determine the concentration of the blood constituent. In one embodiment, the fluid constituent comprises blood glucose.
A further aspect of the present invention involves a method of actively varying the attenuation of optical radiation due to blood in a fleshy medium. The method comprises a plurality of steps. Optical radiation is transmitted through the fleshy medium. A periodic change in the volume of blood is actively influenced in the medium The optical radiation is detected after attenuation through the fleshy medium and an output signal indicative of the intensity of the attenuated signal is generated.
The filter wheel with a broadband light is depicted in
The monitor system 100 has a detector 140, such as a photodetector. The blood glucose monitor 100 also has a pressure inducing cuff 150 to physically squeeze a digit 130 in order to periodically induce a “pulse” in the fluid (i.e., actively vary the flow of fluid) in a digit 130. In other words, a device influences a change in the volume of blood in the digit or other fleshy medium. A window 111 is positioned to allow light from the emitter 110 to pass through the window 11 and transmit through the digit 130. This intentional active perturbation of the blood in the digit or medium under test is further referred to herein as an “active pulse.” The blood glucose monitor also has a display 160 which may be used to indicate such parameters as glucose concentration and signal quality. Advantageously, the blood glucose monitor also has a power switch 154, a start switch 156 and a trend data switch 158.
Other methods of inducing a pulse are also possible. For instance, the fleshy medium under test, such as the patient's digit, could be perturbed with a pressure device 152 (depicted in dotted lines in
The pressure device 152, the cuff 150 and the use of temperature to induce a pulse in the fleshy medium are advantageous in that they can be used with minimal or no movement of the fleshy medium in the area through which light is transmitted. This is possible through inducing the pulse at a location proximal or distal from the area receiving the incident light. The advantage of minimal movement is that movement in the area of the fleshy medium under test causes variation in the detected signal other than due to the varying fluid volume (e.g., blood and interstitial fluid) flow. For instance, physical perturbation in the area of light transmission can cause changes in the light coupling to the medium under test resulting in variations in attenuation which are not due to changes in fluid volume in the area of light transmission. These other variations comprise additional noise that should be removed for accurate measurement.
As well understood in the art, because Beer-Lambert's law contains a term for each constituent which attenuates the signal, one wavelength is provided for each constituent which is accounted for. For increased precision, the wavelengths are chosen at points where attenuation for each particular constituent is the greatest and attenuation by other constituents is less significant.
[log(log(average water))]−[log(log(6400 mg/dl glucose))]
However, for purposes of choosing appropriate wavelengths, the scale is of less significance that the points at which Glucose and the other constituents show good attenuation and the attenuation is not totally obscured by other constituents in the medium.
In the present embodiment, advantageous wavelengths for the emitters 301-305 (or to obtain with the filter wheel and signal processing) are 660 nm (good attenuation hemoglobin), 905 nm (good attenuation from oxyhemoglobin), 1270 nm (good attenuation by water, and little attenuation by other constituents) 1330-1340 nm (good attenuation due to Glucose in the area of the graph labelled A of
In addition to using multiple precise LEDs, an optical spectroscopic system for generating the optical characteristics over many wavelengths can be used. Such a device is disclosed in U.S. patent application Ser. No. 08/479,164, entitled Blood Glucose Monitoring System, filed on the same day as this application, and assigned to the assignee of this application.
The sensor 300 further comprises a detector 320 (e.g., a photodetector), which produces an electrical signal corresponding to the attenuated light energy signals. The detector 320 is located so as to receive the light from the emitters 301-305 after it has propagated through at least a portion of the medium under test. In the embodiment depicted in
The front end analog signal conditioning circuitry 330 has outputs coupled to analog to digital conversion circuit 332. The analog to digital conversion circuitry 332 has outputs coupled to a digital signal processing system 334. The digital signal processing system 334 provides the desired parameter as an output for a display 336. The display 336 provides a reading of the blood glucose concentration.
The signal processing system also provides an emitter current control output 337 to a digital-to-analog converter circuit 338 which provides control information for emitter drivers 340. The emitter drivers 340 couple to the emitters; 301-305. The digital signal processing system 334 also provides a gain control output 342 for the front end analog signal conditioning circuitry 330.
The preferred driver depicted in
The voltage reference is also chosen as a low noise DC voltage reference for the digital to analog conversion circuit 325. In addition, in the present embodiment, the voltage reference has an lowpass output filter with a very low corner frequency (e.g., 1 Hz in the present embodiment). The digital to analog converter 325 also has a lowpass filter at its output with a very low corner frequency (e.g., 1 Hz). The digital to analog converter provides signals for each of the emitters 301, 302 (and the remaining emitters 303-305, not depicted in
In the present embodiment, the output of the voltage to current converters 328, 329 are switched such that with the emitters 301, 302 connected in back-to-back configuration, only one emitter is active an any given time. A refusal position for the switch 326 is also provided to allow the emitters 301 and 302 to both be off when one of the other emitters 303-305 is on with a similar switching circuit. In addition, the voltage to current converter for the inactive emitter is switched off at its input as well, such that it is completely deactivated. This reduces noise from the switching and voltage to current conversion circuitry. In the present embodiment, low noise voltage to current converters are selected (e.g., Op 27 Op Amps), and the feedback loop is configured to have a low pass filter to reduce noise. In the present embodiment, the low pass filtering function of the voltage to current converter 328, 329 has a corner frequency just above the switching speed for the emitters. Accordingly, the preferred driver circuit of
As represented in
The digital signal processing system 334 also provides control for driving the light emitters 301-305 with an emitter current control signal on the emitter current control output 337. This value is a digital value which is converted by the digital-to-analog conversion circuit 338 which provides a control signal to the emitter current drivers 340. The emitter current drivers 340 provide the appropriate current drive for the emitters 301-305.
In the present embodiment, the emitters 301-305 are driven via the emitter current driver 340 to provide light transmission with digital modulation at 625 Hz. In the present embodiment, the light emitters 301-305 are driven at a power level which provides an acceptable intensity for detection by the detector and for conditioning by the front end analog signal conditioning circuitry 330. Once this energy level is determined for a given patient by the digital signal processing system 334, the current level for the emitters is maintained constant. It should be understood, however, that the current could be adjusted for changes in the ambient room light and other changes which would effect the voltage input to the front end analog signal conditioning circuitry 330. In the present invention, light emitters are modulated as follows: for one complete 625 Hz cycle for the first wavelength, the first emitter 301 is activated for the first tenth of the cycle, and off for the remaining nine-tenths of the cycle; for one complete 625 Hz second wavelength cycle, the second light emitter 302 is activated for the one tenth of the cycle and off for the remaining nine-tenths cycle; for one 625 Hz third wavelength cycle, the third light emitter 303 is activated for one tenth cycle and is off for the remaining nine-tenths cycle; for one 625 Hz fourth wavelength cycle, the fourth light emitter 304 is activated for one tenth cycle and is off for the remaining nine-tenths cycle; and for one 625 Hz fifth wavelength cycle, the fifth light emitter 305 is activated for one tenth cycle and is off for the remaining nine-tenths cycle. In order to receive only one signal at a time, the emitters are cycled on and off alternatively, in sequence, with each only active for a tenth cycle per 625 Hz cycle and a tenth cycle separating the active times.
The light signal is attenuated (amplitude modulated) by the blood (with the volume of blood changing through cyclic active pulse in the present embodiment) through the finger 310 (or other sample medium). In the present embodiment, the fingertip 130 is physiologically altered on a periodic basis by the pressure device 150 (or the active pulse device) so that approximately 10% amplitude modulation is achieved. That is, enough-pressure is applied to the fingertip 310 to evacuate a volume of body fluid such that the variation in the overall difference in optical attenuation observed between the finger tip 310 when full of blood and the finger tip 310 when blood is evacuated, is approximately 10%. For example, if the transmission of optical radiation through the fingertip 310 is approximately 0.4%, then the fingertip 310 would have to be physiologically altered to evacuate enough blood so that the attenuation of the fingertip having fluid evacuated would be on the order to 0.36%.
In one advantageous embodiment, physiological altering of the fingertip 310 is accomplished by the application of periodic gentle pressure to the patient's finger 310 with the pressure cuff 150 (
The modulation is performed at a selected rate. A narrow band pass filter may then be employed to isolate the frequency of interest. In the present embodiment, the modulation obtained through influencing an active pulse preferably occurs at a rate just above the normal heart rate (for instance, 4 Hz). In one embodiment, the system checks the heart rate and sets the active pulse rate such that it is above the natural heart rate, and also away from harmonics of the natural pulse rate. This allows for easy filtering with a very narrow band-pass filter with a center frequency of at the selected active pulse rate (e.g., 4 Hz or the rate automatically selected by the system to be away from the fundamental natural heart rate frequency and any harmonics to the fundamental frequency). However, a frequency in or below the range of normal heart rate could also be used. Indeed, in one embodiment, the frequency tracks the heart rate, in which case the active pulse operates in conjunction with the natural pulse to increase the change in volume of flow with each heart beat.
The attenuated (amplitude modulated) signal is detected by the photodetector 320 at the 625 Hz carrier frequency for each emitter. Because only a single photodetector is used, the photodetector 320 receives all the emitter signals to form a composite time division signal. In the present embodiment, a photodetector is provided which is a sandwich-type photodetector with a first layer which is transparent to infrared wavelengths but detects red wavelengths and a second layer which detects infrared wavelengths. One suitable photodetector is a K1713-05 photodiode made by Hamamatsu Corp. This photodetector provides for detection by the infrared layer of a relatively large spectrum of infrared wavelengths, as well as detection of a large spectrum of wavelengths in the red range by the layer which detects red wavelengths, with a single photodetector. Alternatively, multiple photodetectors could be utilized for the wavelengths in the system.
The composite time division signal is provided to the front analog signal conditioning circuitry 330. Additional detail regarding the front end analog signal conditioning circuitry 330 and the analog to digital converter circuit 332 is illustrated in
The output of the preamplifier 342 couples as an input to the high pass filter 344. The output of the preamplifier also provides a first input 347 to the analog to digital conversion circuit 332. In the present embodiment, the high pass filter is a single-pole filter with a corner frequency of about ½-1 Hz. However, the corner frequency is readily raised to about 90 Hz in one embodiment. As will be understood; the 625 Hz carrier frequency of the emitter signals is well above a 90 Hz corner frequency. The high-pass filter 344 has an output coupled as an input to an amplifier 346. In the present embodiment, the amplifier 346 comprises a unity gain transimpedance amplifier. However, the gain of the amplifier 346 is adjustable by the variation of a single resistor. The gain of the amplifier 346 would be increased if the gain of the preamplifier 342 is decreased to compensate for the effects of ambient light.
The output of the amplifier 346 provides an input to a programmable gain amplifier 348. The programmable gain amplifier 348 also accepts a programming input from the digital signal processing system 334 on a gain control signal line 343. The gain of the programmable gain amplifier 348 is digitally programmable. The gain is adjusted dynamically at initialization or sensor placement for changes in the medium under test from patient to patient. For example, the signal from different fingers differs somewhat. Therefore, a dynamically adjustable amplifier is provided by the programmable gain amplifier 348 in order to obtain a signal suitable for processing.
The output of the programmable gain amplifier 348 couples as an input to a low-pass filter 350. Advantageously, the low pass filter 350 is a single-pole filter with a corner frequency of approximately 10 Khz in the present embodiment. This low pass filter provides antialiasing in the present embodiment.
The output of the low-pass filter 350 provides a second S input 352 to the analog-to-digital conversion circuit 332.
In one advantageous embodiment, the first analog-to-digital converter 354 is a diagnostic analog-to-digital converter. The diagnostic task (performed by the digital signal processing system) is to read the output of the detector as amplified by the preamplifier 342 in order to determine if the signal is saturating the input to the high-pass filter 344. In the present embodiment, if the input to the high pass filter 344 becomes saturated, the front end analog signal conditioning circuits 330 provides a ‘0’ output. Alternatively, the first analog-to-digital converter 354 remains unused.
The second analog-to-digital converter 352 accepts the conditioned composite analog signal from the front end signal conditioning circuitry 330 and converts the signal to digital form. In the present embodiment, the second analog to digital converter 356 comprises a single-channel, delta-sigma converter. This converter is advantageous in that it is low cost, and exhibits low noise characteristics. In addition, by using a single-channel converter, there is no need to tune two or more channels to each other. The delta-sigma converter is also advantageous in that it exhibits noise shaping, for improved noise control. An exemplary analog to digital converter is an Analog Devices AD1877JR. In the present embodiment; the second analog to digital converter 356 samples the signal at a 50 Khz sample rate. The output of the second analog to digital converter 356 provides data samples at 50 Khz to the digital signal processing system 334 (
The digital signal processing system 334 is illustrated in additional detail in
The microcontroller 360 is connected to the DSP 362 via a conventional JTAG Tap line. The microcontroller 360 transmits the boot loader for the DSP 362 to the program memory 364 via the Tap line, and then allows the DSP 362 to boot from the program memory 364. The boot loader in program memory 364 then causes the transfer of the operating instructions for the DSP 362 from the read only memory 370 to the program memory 364. Advantageously, the program memory 364 is a very high speed memory for the DSP 362.
The microcontroller 360 provides the emitter current control and gain control signals via the communications register 372.
In general, the demodulation operation separates each emitter signal from the composite signal and removes the 625 Hz carrier frequency, leaving raw data points. The raw data points are provided at 625 Hz intervals to the decimation operation which reduces the samples by an order of 10 to samples at 62.5 Hz. The decimation operation also provides some filtering on the samples. The resulting data is subjected to normalization (which essentially generates a normalized AC/DC signal) and then glucose concentration is determined in the Glucose Calculation module 408.
Because the signal processing system 334 controls the activation of the light emitters 301-305, the entire system is synchronous. The data is synchronously divided (and thereby demodulated) into the eight-sample packets, with a time division demultiplexing operation as represented in a demultiplexing module 421. One eight-sample packet 422 represents the first emitter wavelength plus ambient light signal; a second eight-sample packet 424 represents an ambient light signal; a third eight-sample packet 426 represents the attenuated second emitter wavelength light plus ambient light signal; and a fourth eight-sample packet 428 represents the ambient light signal. Again, this continues until there is a eight-sample packet for each emitter active period with an accompanying eight-sample packet for the corresponding ambient light period. A select signal synchronously controls the demultiplexing operation so as to divide the time-division multiplexed composite signal at the input of the demultiplexer 421 into its representative subparts or packets.
A sum of the four last samples from each packet is then calculated, as represented in the summing operations 430, 432, 434, 436 of
It should be understood that the 625 Hz carrier frequency has been removed by the demodulation operation 400. The 625 Hz sample data at the output of the demodulation operation 400 is sample data without the carrier frequency. In order to satisfy Nyquist sampling requirements, less than 10 Hz is needed (with an active pulse of about 4 Hz in the present embodiment). Accordingly, the 625 Hz resolution is reduced to 62.5 Hz in the decimation operation.
Once the DC signal is removed, the signals are subjected to bandpass filtering, as represented in Bandpass Filter modules 488, 490. In the present embodiment, with 570 samples in each packet, the bandpass filters are configured with 301 taps to provide a FIR filter with a linear phase response and little or no distortion. In the present embodiment, the bandpass filter has a narrow passband from 3.7-4.3 Hz. This provides a narrow passband which eliminates most noise and leaves the portion of the signal due to the active pulse. The 301 taps slide over the 570 samples in order to obtain 270 filtered samples representing the filtered signal of the first emitter wavelength and 270 filtered samples representing the filtered signal of the second emitter wavelength, continuing for each emitter wavelength. In an ideal case, the bandpass filters 488, 490 assist in removing the DC in the signal. However, the DC removal operation 484, 486 also assists in DC removal in the present embodiment.
After filtering, the last 120 samples from each packet (of now 270 samples in the present embodiment) are selected for further processing as represented in Select Last 120 Samples modules 492, 494. The last 120 samples are selected in order to provide settling time for the system.
The RMS for the samples is then determined for each of the 120-sample packets (for each wavelength). The process to obtain the overall RMS values is represented in the RMS modules 495-499.
The resultant RMS values for each wavelength provide normalized intensity values for forming equations according to Beer-Lambert's law. In other words, for Beer-Lambert equation
then taking the log of operations 480-482:
Then performing DC removal though the DC removal operations 484, 486 and Band pass filter operations 488, 490, the the normalized equation becomes:
The RMS values (blocks 495-499) for each wavelength provide lnormλ for the left side of Equation (7). The extinction coefficients are known for the selected wavelengths.
As will be understood, each equation has a plurality of unknowns. Specifically, each equation will have an unknown term which is the product of concentration and pathlength for each of the constituents of concern (hemoglobin, oxyhemoglobin, glucose and water in the present embodiment). Once a normalized Beer-Lambert equation is formed for each wavelength RMS value (the RMS value representing the normalized intensity for that wavelength), a matrix is formed as follows:
C1=concentration of water
C2=concentration of hemoglobin
C3=concentration of oxyhemoglobin
C4=concentration of Glucose
C5=concentration of Glucose
ε1λn=extinction coefficient for water at λn
ε2λn=extinction coefficient for hemoglobin at λn
ε3λn=extinction coefficient for oxyhemoglobin at λn
ε4λn=extinction coefficient for Glucose at λn
ε5λn=extinction coefficient for Glucose at λn
The equations are solved using conventional matrix algebra in order to solve for the product of concentration times pathlength for each constituent, as represented in the Matrix block 489.
In order to remove the path length term, in the present embodiment where glucose is desired, a ratio is performed of the product of pathlength times concentration for glucose to the product of pathlength times the concentration of water as represented in a ratio block 487. Since the pathlength is substantially the same for each wavelength due to normalization (i.e., taking AC/DC) and due to minimal perturbation (e.g., 10%), the pathlength terms cancel, and the ratio indicates the concentration of glucose to water (preferably, this is scaled to mg/dL). The glucose concentration is provided to the display 336.
It should be noted that it may also be possible to create an empirical table by way of experiment which correlates ratios of one or more of the concentration times path length terms to blood glucose concentration.
Even with the emitter driver circuit of
Accordingly, in one embodiment, the emitters in the 1300 nm range are selected as with an integrated photodetector. An appropriate laser diode is an SCW-1300-CD made by Laser Diode, Inc. An appropriate LED is an Apitaxx ETX1300T. With such an emitter, a configuration as depicted in
After analog signal conditioning in the front end anaolog signal conditioning circuity 330A, the signal from the photodiode 301a is converted to digital form with an analog to digital conversion circuit 332a. Again, it should be understood that the analog to digital conversion circuit 332a can be the same configuration as the analog to digital conversion circuit 332. However, because the signal from the photodiode 301a and the detector 320 appear at the same time, two channels are required.
The attenuated light signal through the finger is detected with the detector 320 and passed through front end analog signal conditioning circuit 330 and is converted-to-digital form in analog to digital conversion circuit 332, as described in further detail below. The signal representing the intensity of the light transmitted through the finger 310 is divided as represented by the division block 333 by the signal which represents the intensity of light from the LED 301b detected by the photodiode 301a.
In this manner, the variations or instability in the initial intensity lo cancel through the division leaving a corrected intensity which is divided by the constant α. When the log is performed as discussed below, and bandpass filtering is performed, the constant .alpha. term is removed leaving a clean signal.
Mathmatically, this can be understood by representing the attenuated signal under Beer-Lambert's Law and the signal from the photodiode 301a as αlo as discussed above:
Thus, the signal emerging from the analog to digital conversion circuit 332 is as follows:
Dividing Equation 3 by α*lo and simplifying provides the signal after the division operation 333:
Thus providing a normalized intensity signal for the input to the digital signal processing circuit 334.
Typically, the electrical connection 502 carries sufficient conductors to power the emitters 301-305 and to receive a detector signal from the detector 320.
The inflatable bladder sensor 500 has a curved upper surface 504 and vertical sides 506. The inflatable bladder sensor 500 also has an fluid pressure supply tube 508. In one advantageous embodiment, the supply tube cycles air into and out of an inflatable bladder within the inflatable bladder sensor 500. The fluid supply tube 508 couples to the bedside glucose monitoring system which is equipped with a cycling pump to induce pressure and remove pressure from the supply tube 508. In one embodiment, a pressure relief valve 510 is located on the upper surface 504 to allow release of pressure in the inflatable bladder.
Surrounded by the padding 514 and opposite the emitters 301-305 is the detector 320. The detector 320 is positioned within an aperture 520 in the pad 514 to ensure that photodetector is separated from the finger 512. A serpentine arrow is shown extending from the light emitters 301-305 to the detector 320 to illustrate the direction of propagation of light energy through the finger 512.
Relief valve 510 enables manual and automatic release of pressure in the inflatable bladder 516. Relief valve 510 has a valve plate 522 which is spring biased to seal an aperture 524 using spring 532. The valve plate is connected to relief valve shaft 526. A valve button 530 is coupled to the valve shaft. The valve shaft extends through a valve housing 531 which forms a cylindrical sleeve shape. The valve housing is coupled to the upper surface 504 of sensor 500. The valve housing has an aperture 523 which allows air to readily escape from the relief valve. Preferably, the relief valve is designed to ensure that the pressure is not high enough to cause damage to nerves. Accordingly, if the pressure increases beyond a certain point, the relief valve allows the excess fluid to escape, thereby reducing the pressure to the maximum allowable limit. Such pressure relief valves are well understood in the art. Relief valve 510 could also be a spring-loaded needle-type valve.
With this configuration, the blood glucose system can cycle fluid into and out of the inflatable bladder 516 at the selected rate to actively induce a pulse of sufficient magnitude as discussed above.
Additional Application of Active Pulse
As discussed in the co-pending U.S. patent application Ser. No. 08/320,154 filed Oct. 7, 1994, now U.S. Pat. No. 5,632,272 which is incorporated herein by reference, a saturation transform may be applied to each 120 sample packet. It has been found that a second maxima representing venous oxygen saturation exists in the Master Power Curve during motion of the patient. In view of this, it is possible to utilize the inducement of a pulse disclosed herein through physically perturbing the medium under test in order to obtain the second maxima in the Master Power Curve, and thereby obtain the venous oxygen saturation if desired. The modulation may be lower than 10% because hemoglobin and oxyhemoglobin concentrations are higher than glucose and absorbtion at 660 nm and 905 nm are relatively strong. Thus, modulation from 1-5% may provide adequate results.
Although the preferred embodiment of the present invention has been described and illustrated above, those skilled in the art will appreciate that various changes and modifications to the present invention do not depart from the spirit of the invention. For example, the principles and method of the present invention could be used to detect trace elements within the bloodstream (e.g., for drug testing, etc.). Accordingly, the scope of the present invention is limited only by the scope of the following appended claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3482565||Mar 24, 1964||Dec 9, 1969||Carter Wallace||Digital blood pressure measuring device|
|US3704708||May 4, 1970||Dec 5, 1972||Gen Technical Services Inc||Blood pressure measuring mechanism|
|US3771857||Apr 19, 1971||Nov 13, 1973||Optical Coating Laboratory Inc||Striped dichroic filter and method for making the same|
|US3914464||May 21, 1973||Oct 21, 1975||Optical Coating Laboratory Inc||Striped dichroic filter and method for making the same|
|US3981568||Jul 1, 1974||Sep 21, 1976||Optical Coating Laboratory, Inc.||Striped dichroic filter with butted stripes and dual lift-off method for making the same|
|US4406289||Sep 10, 1981||Sep 27, 1983||Nederlandse Centrale Organisatie Voor Toegepast-Natuurwetenschappelijk||Device for the indirect, non-invasive and continuous measurement of blood pressure|
|US4407290||Apr 1, 1981||Oct 4, 1983||Biox Technology, Inc.||Blood constituent measuring device and method|
|US4883055||Mar 11, 1988||Nov 28, 1989||Puritan-Bennett Corporation||Artificially induced blood pulse for use with a pulse oximeter|
|US4927264||Dec 1, 1988||May 22, 1990||Omron Tateisi Electronics Co.||Non-invasive measuring method and apparatus of blood constituents|
|US4957371||Dec 11, 1987||Sep 18, 1990||Santa Barbara Research Center||Wedge-filter spectrometer|
|US4960128||Nov 14, 1988||Oct 2, 1990||Paramed Technology Incorporated||Method and apparatus for continuously and non-invasively measuring the blood pressure of a patient|
|US4964408||Apr 29, 1988||Oct 23, 1990||Thor Technology Corporation||Oximeter sensor assembly with integral cable|
|US5007423||Oct 4, 1989||Apr 16, 1991||Nippon Colin Company Ltd.||Oximeter sensor temperature control|
|US5041187||Oct 1, 1990||Aug 20, 1991||Thor Technology Corporation||Oximeter sensor assembly with integral cable and method of forming the same|
|US5069213||Dec 19, 1989||Dec 3, 1991||Thor Technology Corporation||Oximeter sensor assembly with integral cable and encoder|
|US5077476||Aug 10, 1990||Dec 31, 1991||Futrex, Inc.||Instrument for non-invasive measurement of blood glucose|
|US5111817||Dec 29, 1988||May 12, 1992||Medical Physics, Inc.||Noninvasive system and method for enhanced arterial oxygen saturation determination and arterial blood pressure monitoring|
|US5163438||Sep 24, 1990||Nov 17, 1992||Paramed Technology Incorporated||Method and apparatus for continuously and noninvasively measuring the blood pressure of a patient|
|US5183042||Jul 3, 1991||Feb 2, 1993||Vivascan Corporation||Electromagnetic method and apparatus to measure constituents of human or animal tissue|
|US5200855||Jul 12, 1991||Apr 6, 1993||Optical Coating Laboratory, Inc.||Absorbing dichroic filters|
|US5282467 *||Aug 13, 1992||Feb 1, 1994||Duke University||Non-invasive method for detecting deep venous thrombosis in the human body|
|US5337744||Jul 14, 1993||Aug 16, 1994||Masimo Corporation||Low noise finger cot probe|
|US5348003 *||Sep 3, 1992||Sep 20, 1994||Sirraya, Inc.||Method and apparatus for chemical analysis|
|US5361758 *||Oct 9, 1991||Nov 8, 1994||Cme Telemetrix Inc.||Method and device for measuring concentration levels of blood constituents non-invasively|
|US5372135||Mar 21, 1994||Dec 13, 1994||Vivascan Corporation||Blood constituent determination based on differential spectral analysis|
|US5372136||Feb 1, 1993||Dec 13, 1994||Noninvasive Medical Technology Corporation||System and method for noninvasive hematocrit monitoring|
|US5379774||Mar 25, 1994||Jan 10, 1995||Sankyo Company Limited||Measurement of arterial elasticity and the frequency characteristic of the compliance of an artery|
|US5398681||Jan 22, 1993||Mar 21, 1995||Sunshine Medical Instruments, Inc.||Pocket-type instrument for non-invasive measurement of blood glucose concentration|
|US5413100 *||Jan 21, 1994||May 9, 1995||Effets Biologiques Exercice||Non-invasive method for the in vivo determination of the oxygen saturation rate of arterial blood, and device for carrying out the method|
|US5416325||Apr 29, 1993||May 16, 1995||Arch Development Corporation||Fourier transform infrared spectrometer|
|US5416579||Jul 21, 1994||May 16, 1995||Nova Chem Bv||Method for determining concentration in a solution using attenuated total reflectance spectrometry|
|US5431170||May 28, 1991||Jul 11, 1995||Mathews; Geoffrey R.||Pulse responsive device|
|US5452717||Jun 2, 1994||Sep 26, 1995||Masimo Corporation||Finger-cot probe|
|US5482036||May 26, 1994||Jan 9, 1996||Masimo Corporation||Signal processing apparatus and method|
|US5490505||Oct 6, 1993||Feb 13, 1996||Masimo Corporation||Signal processing apparatus|
|US5494043||May 4, 1993||Feb 27, 1996||Vital Insite, Inc.||Arterial sensor|
|US5522388||Sep 15, 1994||Jun 4, 1996||Kowa Company Ltd.||Pulse spectrometer|
|US5529755||Feb 16, 1995||Jun 25, 1996||Minolta Co., Ltd.||Apparatus for measuring a glucose concentration|
|US5533511||Jan 5, 1994||Jul 9, 1996||Vital Insite, Incorporated||Apparatus and method for noninvasive blood pressure measurement|
|US5562002||Feb 3, 1995||Oct 8, 1996||Sensidyne Inc.||Positive displacement piston flow meter with damping assembly|
|US5590649||Apr 15, 1994||Jan 7, 1997||Vital Insite, Inc.||Apparatus and method for measuring an induced perturbation to determine blood pressure|
|US5602924||Dec 9, 1993||Feb 11, 1997||Theratechnologies Inc.||Electronic stethescope|
|US5632272||Oct 7, 1994||May 27, 1997||Masimo Corporation||Signal processing apparatus|
|US5638816||Jun 7, 1995||Jun 17, 1997||Masimo Corporation||Active pulse blood constituent monitoring|
|US5638818||Nov 1, 1994||Jun 17, 1997||Masimo Corporation||Low noise optical probe|
|US5645440||Oct 16, 1995||Jul 8, 1997||Masimo Corporation||Patient cable connector|
|US5685299||Dec 14, 1995||Nov 11, 1997||Masimo Corporation||Signal processing apparatus|
|US5743262||Jun 7, 1995||Apr 28, 1998||Masimo Corporation||Blood glucose monitoring system|
|US5758644||Jun 7, 1995||Jun 2, 1998||Masimo Corporation||Manual and automatic probe calibration|
|US5760910||Jun 7, 1995||Jun 2, 1998||Masimo Corporation||Optical filter for spectroscopic measurement and method of producing the optical filter|
|US5769785||Jun 7, 1995||Jun 23, 1998||Masimo Corporation||Signal processing apparatus and method|
|US5782757||Oct 16, 1995||Jul 21, 1998||Masimo Corporation||Low-noise optical probes|
|US5785659||May 17, 1996||Jul 28, 1998||Vital Insite, Inc.||Automatically activated blood pressure measurement device|
|US5791347||Aug 14, 1996||Aug 11, 1998||Vital Insite, Inc.||Motion insensitive pulse detector|
|US5810734||Nov 22, 1995||Sep 22, 1998||Vital Insite, Inc.||Apparatus and method for measuring an induced perturbation to determine a physiological parameter|
|US5823950||Nov 12, 1996||Oct 20, 1998||Masimo Corporation||Manual and automatic probe calibration|
|US5830131||Nov 22, 1995||Nov 3, 1998||Vital Insite, Inc.||Apparatus and method for measuring an induced perturbation to determine a physical condition of the human arterial system|
|US5833618||Nov 22, 1995||Nov 10, 1998||Vital Insite, Inc.||Apparatus and method for measuring an induced perturbation to determine a physiological parameter|
|US5860919||Apr 17, 1997||Jan 19, 1999||Masimo Corporation||Active pulse blood constituent monitoring method|
|US5890929||Jun 3, 1997||Apr 6, 1999||Masimo Corporation||Shielded medical connector|
|US5904654||Feb 26, 1996||May 18, 1999||Vital Insite, Inc.||Exciter-detector unit for measuring physiological parameters|
|US5919134||Jan 12, 1998||Jul 6, 1999||Masimo Corp.||Method and apparatus for demodulating signals in a pulse oximetry system|
|US5934925||Apr 9, 1997||Aug 10, 1999||Masimo Corporation||Patient cable connector|
|US5940182||Jun 1, 1998||Aug 17, 1999||Masimo Corporation||Optical filter for spectroscopic measurement and method of producing the optical filter|
|US5995855||Feb 11, 1998||Nov 30, 1999||Masimo Corporation||Pulse oximetry sensor adapter|
|US5997343||Mar 19, 1998||Dec 7, 1999||Masimo Corporation||Patient cable sensor switch|
|US6002952||Apr 14, 1997||Dec 14, 1999||Masimo Corporation||Signal processing apparatus and method|
|US6011986||Feb 2, 1998||Jan 4, 2000||Masimo Corporation||Manual and automatic probe calibration|
|US6027452||Jun 26, 1996||Feb 22, 2000||Vital Insite, Inc.||Rapid non-invasive blood pressure measuring device|
|US6036642||Jun 22, 1998||Mar 14, 2000||Masimo Corporation||Signal processing apparatus and method|
|US6045509||Feb 19, 1998||Apr 4, 2000||Vital Insite, Inc.||Apparatus and method for measuring an induced perturbation to determine a physiological parameter|
|US6067462||May 19, 1998||May 23, 2000||Masimo Corporation||Signal processing apparatus and method|
|US6081735||Jul 3, 1997||Jun 27, 2000||Masimo Corporation||Signal processing apparatus|
|US6088607||Jan 28, 1997||Jul 11, 2000||Masimo Corporation||Low noise optical probe|
|US6110522||Apr 16, 1998||Aug 29, 2000||Masimo Laboratories||Blood glucose monitoring system|
|US6144868||Apr 12, 1999||Nov 7, 2000||Sensidyne, Inc.||Reusable pulse oximeter probe and disposable bandage apparatus|
|US6151516||Nov 12, 1998||Nov 21, 2000||Masimo Laboratories||Active pulse blood constituent monitoring|
|US6152754||Dec 21, 1999||Nov 28, 2000||Masimo Corporation||Circuit board based cable connector|
|US6157850||May 16, 1997||Dec 5, 2000||Masimo Corporation||Signal processing apparatus|
|US6165005||Dec 7, 1999||Dec 26, 2000||Masimo Corporation||Patient cable sensor switch|
|US6184521||Jan 6, 1998||Feb 6, 2001||Masimo Corporation||Photodiode detector with integrated noise shielding|
|US6191860||Aug 6, 1999||Feb 20, 2001||Orsense Ltd.||Optical shutter, spectrometer and method for spectral analysis|
|US6206830||Nov 17, 1999||Mar 27, 2001||Masimo Corporation||Signal processing apparatus and method|
|US6213952||Sep 28, 1999||Apr 10, 2001||Orsense Ltd.||Optical device for non-invasive measurement of blood related signals utilizing a finger holder|
|US6229856||Apr 10, 1998||May 8, 2001||Masimo Corporation||Method and apparatus for demodulating signals in a pulse oximetry system|
|US6236872||Nov 25, 1998||May 22, 2001||Masimo Corporation||Signal processing apparatus|
|US6256523||Jun 9, 1998||Jul 3, 2001||Masimo Corporation||Low-noise optical probes|
|US6263222||Oct 6, 1997||Jul 17, 2001||Masimo Corporation||Signal processing apparatus|
|US6278522||May 26, 1999||Aug 21, 2001||Masimo Laboratories||Optical filter for spectroscopic measurement and method of producing the optical filter|
|US6280213||Nov 7, 2000||Aug 28, 2001||Masimo Corporation||Patient cable connector|
|US6285896||Jul 7, 1999||Sep 4, 2001||Masimo Corporation||Fetal pulse oximetry sensor|
|US6321100||Jul 13, 1999||Nov 20, 2001||Sensidyne, Inc.||Reusable pulse oximeter probe with disposable liner|
|US6334065||May 27, 1999||Dec 25, 2001||Masimo Corporation||Stereo pulse oximeter|
|US6343224||Oct 14, 1999||Jan 29, 2002||Sensidyne, Inc.||Reusable pulse oximeter probe and disposable bandage apparatus|
|US6349228||Sep 23, 1999||Feb 19, 2002||Masimo Corporation||Pulse oximetry sensor adapter|
|US6360114||Mar 21, 2000||Mar 19, 2002||Masimo Corporation||Pulse oximeter probe-off detector|
|US6371921||Nov 1, 1999||Apr 16, 2002||Masimo Corporation||System and method of determining whether to recalibrate a blood pressure monitor|
|US6377829||Dec 9, 1999||Apr 23, 2002||Masimo Corporation||Resposable pulse oximetry sensor|
|US6388240||Mar 2, 2001||May 14, 2002||Masimo Corporation||Shielded optical probe and method having a longevity indication|
|US6397091||Nov 30, 1999||May 28, 2002||Masimo Corporation||Manual and automatic probe calibration|
|US6400971||Oct 12, 1999||Jun 4, 2002||Orsense Ltd.||Optical device for non-invasive measurement of blood-related signals and a finger holder therefor|
|US6400972||Dec 21, 1999||Jun 4, 2002||Orsense Ltd.||Non-invasive method and system of optical measurements for determining the concentration of a substance in blood|
|US6430525||Jun 5, 2000||Aug 6, 2002||Masimo Corporation||Variable mode averager|
|US6463311||Dec 23, 1999||Oct 8, 2002||Masimo Corporation||Plethysmograph pulse recognition processor|
|US6470199||Jun 21, 2000||Oct 22, 2002||Masimo Corporation||Elastic sock for positioning an optical probe|
|US6501975||Jan 9, 2001||Dec 31, 2002||Masimo Corporation||Signal processing apparatus and method|
|US6515273||Feb 10, 2000||Feb 4, 2003||Masimo Corporation||System for indicating the expiration of the useful operating life of a pulse oximetry sensor|
|US6519487||Oct 5, 2000||Feb 11, 2003||Sensidyne, Inc.||Reusable pulse oximeter probe and disposable bandage apparatus|
|US6525386||Mar 10, 1998||Feb 25, 2003||Masimo Corporation||Non-protruding optoelectronic lens|
|US6526300||Jun 16, 2000||Feb 25, 2003||Masimo Corporation||Pulse oximeter probe-off detection system|
|US6541756||Jan 25, 2001||Apr 1, 2003||Masimo Corporation||Shielded optical probe having an electrical connector|
|US6542764||Dec 1, 2000||Apr 1, 2003||Masimo Corporation||Pulse oximeter monitor for expressing the urgency of the patient's condition|
|US6580086||Oct 19, 1999||Jun 17, 2003||Masimo Corporation||Shielded optical probe and method|
|US6584336||Mar 1, 2000||Jun 24, 2003||Masimo Corporation||Universal/upgrading pulse oximeter|
|US6587704||Aug 31, 2000||Jul 1, 2003||Orsense Ltd.||Method for non-invasive optical measurements of blood parameters|
|US6595316||Jul 18, 2001||Jul 22, 2003||Andromed, Inc.||Tension-adjustable mechanism for stethoscope earpieces|
|US6597933||Oct 17, 2001||Jul 22, 2003||Masimo Corporation||Pulse oximetry sensor adapter|
|US6606511||Jan 6, 2000||Aug 12, 2003||Masimo Corporation||Pulse oximetry pulse indicator|
|US6632181||Oct 5, 1999||Oct 14, 2003||Masimo Corporation||Rapid non-invasive blood pressure measuring device|
|US6640116||Aug 9, 2001||Oct 28, 2003||Masimo Corporation||Optical spectroscopy pathlength measurement system|
|US6643530||Dec 13, 2000||Nov 4, 2003||Masimo Corporation||Method and apparatus for demodulating signals in a pulse oximetry system|
|US6650917||Dec 4, 2001||Nov 18, 2003||Masimo Corporation||Signal processing apparatus|
|US6654624||Dec 19, 2001||Nov 25, 2003||Masimo Corporation||Pulse oximeter probe-off detector|
|US6658276||Feb 12, 2002||Dec 2, 2003||Masimo Corporation||Pulse oximeter user interface|
|US6661161||Jun 27, 2002||Dec 9, 2003||Andromed Inc.||Piezoelectric biological sound monitor with printed circuit board|
|US6671531||Dec 11, 2001||Dec 30, 2003||Masimo Corporation||Sensor wrap including foldable applicator|
|US6678543||Nov 8, 2001||Jan 13, 2004||Masimo Corporation||Optical probe and positioning wrap|
|US6684090||May 15, 2001||Jan 27, 2004||Masimo Corporation||Pulse oximetry data confidence indicator|
|US6684091||Jan 11, 2001||Jan 27, 2004||Sensidyne, Inc.||Reusable pulse oximeter probe and disposable bandage method|
|US6697656||Jun 27, 2000||Feb 24, 2004||Masimo Corporation||Pulse oximetry sensor compatible with multiple pulse oximetry systems|
|US6697658||Jun 26, 2002||Feb 24, 2004||Masimo Corporation||Low power pulse oximeter|
|US6699194||Apr 11, 2000||Mar 2, 2004||Masimo Corporation||Signal processing apparatus and method|
|US6711424||Dec 22, 1999||Mar 23, 2004||Orsense Ltd.||Method of optical measurement for determing various parameters of the patient's blood|
|US6714804||Dec 21, 2001||Mar 30, 2004||Masimo Corporation||Stereo pulse oximeter|
|US6721585||Aug 17, 2001||Apr 13, 2004||Sensidyne, Inc.||Universal modular pulse oximeter probe for use with reusable and disposable patient attachment devices|
|US6725075||Apr 23, 2002||Apr 20, 2004||Masimo Corporation||Resposable pulse oximetry sensor|
|US6731963||Sep 7, 2001||May 4, 2004||Orsense Ltd.||Device for enhancement and quality improvement of blood-related signals for use in a system for non-invasive measurements of blood-related signals|
|US6735459||Sep 9, 2002||May 11, 2004||Sensidyne, Inc.||Reusable pulse oximeter probe and disposable bandage apparatus|
|US6745060||Dec 3, 2001||Jun 1, 2004||Masimo Corporation||Signal processing apparatus|
|US6760607||Dec 20, 2001||Jul 6, 2004||Masimo Corporation||Ribbon cable substrate pulse oximetry sensor|
|US6770028||Aug 18, 2000||Aug 3, 2004||Masimo Corporation||Dual-mode pulse oximeter|
|US6771994||Feb 24, 2003||Aug 3, 2004||Masimo Corporation||Pulse oximeter probe-off detection system|
|US6782276||Nov 22, 2000||Aug 24, 2004||Nortel Networks Limited||Signaling aggregator and method for use in a signaling network|
|US6792300||Jul 3, 2001||Sep 14, 2004||Masimo Corporation||Low-noise optical probes for reducing light piping|
|US6804002||Jun 11, 2001||Oct 12, 2004||Orsense Ltd.||Method and device for measuring concentration of glucose or other substances in blood|
|US6813511||Sep 27, 2002||Nov 2, 2004||Masimo Corporation||Low-noise optical probes for reducing ambient noise|
|US6816741||Oct 8, 2002||Nov 9, 2004||Masimo Corporation||Plethysmograph pulse recognition processor|
|US6822564||Jan 24, 2003||Nov 23, 2004||Masimo Corporation||Parallel measurement alarm processor|
|US6826419||Dec 20, 2002||Nov 30, 2004||Masimo Corporation||Signal processing apparatus and method|
|US6830711||Jan 3, 2003||Dec 14, 2004||Masimo Corporation||Mold tool for an optoelectronic element|
|US6850787||Jun 26, 2002||Feb 1, 2005||Masimo Laboratories, Inc.||Signal component processor|
|US6850788||Feb 28, 2003||Feb 1, 2005||Masimo Corporation||Physiological measurement communications adapter|
|US6852083||Jan 17, 2002||Feb 8, 2005||Masimo Corporation||System and method of determining whether to recalibrate a blood pressure monitor|
|US6861639||Feb 3, 2003||Mar 1, 2005||Masimo Corporation||Systems and methods for indicating an amount of use of a sensor|
|US6898452||Sep 22, 2003||May 24, 2005||Masimo Corporation||Stereo pulse oximeter|
|US6920345||Jan 24, 2003||Jul 19, 2005||Masimo Corporation||Optical sensor including disposable and reusable elements|
|US6931268||Nov 6, 2000||Aug 16, 2005||Masimo Laboratories, Inc.||Active pulse blood constituent monitoring|
|US6934570||Dec 19, 2002||Aug 23, 2005||Masimo Corporation||Physiological sensor combination|
|US6939305||Oct 14, 2003||Sep 6, 2005||Masimo Corporation||Rapid non-invasive blood pressure measuring device|
|US6943348||Oct 19, 1999||Sep 13, 2005||Masimo Corporation||System for detecting injection holding material|
|US6950687||Jan 24, 2003||Sep 27, 2005||Masimo Corporation||Isolation and communication element for a resposable pulse oximetry sensor|
|US6961598||Feb 21, 2003||Nov 1, 2005||Masimo Corporation||Pulse and active pulse spectraphotometry|
|US6970792||Dec 3, 2003||Nov 29, 2005||Masimo Laboratories, Inc.||Systems and methods for determining blood oxygen saturation values using complex number encoding|
|US6979812||Feb 24, 2005||Dec 27, 2005||Masimo Corporation||Systems and methods for indicating an amount of use of a sensor|
|US6985764||May 2, 2002||Jan 10, 2006||Masimo Corporation||Flex circuit shielded optical sensor|
|US6993371||Jul 22, 2003||Jan 31, 2006||Masimo Corporation||Pulse oximetry sensor adaptor|
|US6996427||Dec 18, 2003||Feb 7, 2006||Masimo Corporation||Pulse oximetry data confidence indicator|
|US6999904||Aug 5, 2002||Feb 14, 2006||Masimo Corporation||Variable indication estimator|
|US7003338||Jul 8, 2003||Feb 21, 2006||Masimo Corporation||Method and apparatus for reducing coupling between signals|
|US7003339||Nov 3, 2003||Feb 21, 2006||Masimo Corporation||Method and apparatus for demodulating signals in a pulse oximetry system|
|US7015451||Jan 24, 2003||Mar 21, 2006||Masimo Corporation||Power supply rail controller|
|US7024233||Sep 16, 2004||Apr 4, 2006||Masimo Corporation||Pulse oximetry data confidence indicator|
|US7027849||Nov 21, 2003||Apr 11, 2006||Masimo Laboratories, Inc.||Blood parameter measurement system|
|US7030749||Oct 28, 2004||Apr 18, 2006||Masimo Corporation||Parallel measurement alarm processor|
|US7039449||Dec 19, 2003||May 2, 2006||Masimo Corporation||Resposable pulse oximetry sensor|
|US7041060||Sep 6, 2005||May 9, 2006||Masimo Corporation||Rapid non-invasive blood pressure measuring device|
|US7044918||Oct 27, 2004||May 16, 2006||Masimo Corporation||Plethysmograph pulse recognition processor|
|US20020077535||Sep 7, 2001||Jun 20, 2002||Orsense Ltd.||Device for enhancement and quality improvement of blood-related signals for use in a system for non-invasive measurements of blood-related signals|
|US20040116788||Aug 7, 2003||Jun 17, 2004||Orsense Ltd||Method and system for decomposition of multiple channel signals|
|US20040176671||Mar 22, 2004||Sep 9, 2004||Orsense Ltd.||Method of optical measurements for determining various parameters of the patient's blood|
|US20040225205||May 6, 2003||Nov 11, 2004||Orsense Ltd.||Glucose level control method and system|
|US20040249252||Jun 3, 2003||Dec 9, 2004||Orsense Ltd.||Method and system for use in non-invasive optical measurements of blood parameters|
|USD353195||May 28, 1993||Dec 6, 1994||Electronic stethoscope housing|
|USD353196||May 28, 1993||Dec 6, 1994||Stethoscope head|
|USD361840||Apr 21, 1994||Aug 29, 1995||Stethoscope head|
|USD362063||Apr 21, 1994||Sep 5, 1995||Stethoscope headset|
|USD363120||Apr 21, 1994||Oct 10, 1995||Stethoscope ear tip|
|USD393830||Oct 16, 1995||Apr 28, 1998||Masimo Corporation||Patient cable connector|
|USRE38476||Jun 27, 2002||Mar 30, 2004||Masimo Corporation||Signal processing apparatus|
|USRE38492||Mar 11, 2002||Apr 6, 2004||Masimo Corporation||Signal processing apparatus and method|
|JP03126104A2||Title not available|
|1||Fine, I. et al. "RBC Aggregation assisted light transmission through blood and Occlusion Oximetry," 10 pages.|
|2||Landowne, Milton, "A Method Using Induced Waves to Study Pressure Propagation in Human Arteries", Circulation Research, Nov. 1957, pp. 594-601.|
|3||OrSense "Clinical Blood Monitor," http://www.orsense.com/main/siteNew/?page=23, 2 pages downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|4||OrSense "Desktop Blood Monitor," http://www.orsense.com/main/siteNew/?page=22, 2 pages downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|5||OrSense "FAQs," http://www.orsense.com/main/siteNew/?page=10, 3 pages downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|6||OrSense "OrSense Advantages in the Hemoglobin Monitoring Market," http://www.orsense.com/main/siteNew/?page=25, 2 pages downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|7||OrSense "Overview of Hemoglobin Monitoring," http://www.orsense.com/main/siteNew/?page=6, 1 page downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|8||OrSense "Overview of OrSense Technology," http://www.orsense.com/main/siteNew/?page=3, 1 page downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|9||OrSense http://www.orsense.com/main/siteNew/?page=17, 2 pages downloaded and printed from the World Wide Web on Jul. 26, 2005.|
|10||Squire, J.R., "An Instrument for Measuring the Quality of Blood and Its Degree of Oxygenation in Web of the Hand", Clinical Science, vol. 4, pp. 331-339, 1940.|
|11||Wood, Earl H. et al., "Photoelectric Determination of Arterial Oxygen Saturation in Man", Arterial Oxygen Saturation in Man, pp. 387-401, 1948.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US8203438||Jul 28, 2009||Jun 19, 2012||Masimo Corporation||Alarm suspend system|
|US8229533||Jan 25, 2012||Jul 24, 2012||Masimo Corporation||Low-noise optical probes for reducing ambient noise|
|US8306596||Sep 22, 2010||Nov 6, 2012||Glt Acquisition Corp.||Method for data reduction and calibration of an OCT-based physiological monitor|
|US8359080||Feb 15, 2012||Jan 22, 2013||Masimo Corporation||Signal processing apparatus|
|US8364226||Feb 9, 2012||Jan 29, 2013||Masimo Corporation||Signal processing apparatus|
|US8374665||Apr 21, 2008||Feb 12, 2013||Cercacor Laboratories, Inc.||Tissue profile wellness monitor|
|US8430817||Oct 15, 2010||Apr 30, 2013||Masimo Corporation||System for determining confidence in respiratory rate measurements|
|US8437825||Jul 2, 2009||May 7, 2013||Cercacor Laboratories, Inc.||Contoured protrusion for improving spectroscopic measurement of blood constituents|
|US8463349||May 3, 2012||Jun 11, 2013||Masimo Corporation||Signal processing apparatus|
|US8471713||Jul 22, 2010||Jun 25, 2013||Cercacor Laboratories, Inc.||Interference detector for patient monitor|
|US8515509||Aug 3, 2009||Aug 20, 2013||Cercacor Laboratories, Inc.||Multi-stream emitter for noninvasive measurement of blood constituents|
|US8529301||Feb 17, 2012||Sep 10, 2013||Masimo Corporation||Shielded connector assembly|
|US8532727||Aug 20, 2007||Sep 10, 2013||Masimo Corporation||Dual-mode pulse oximeter|
|US8547209||May 21, 2012||Oct 1, 2013||Masimo Corporation||Alarm suspend system|
|US8548549||Sep 9, 2011||Oct 1, 2013||Glt Acquisition Corp.||Methods for noninvasively measuring analyte levels in a subject|
|US8548550||Jul 31, 2012||Oct 1, 2013||Cercacor Laboratories, Inc.||Optical sensor including disposable and reusable elements|
|US8560032||May 22, 2012||Oct 15, 2013||Cercacor Laboratories, Inc.||Noninvasive multi-parameter patient monitor|
|US8560034||Jul 6, 1998||Oct 15, 2013||Masimo Corporation||Signal processing apparatus|
|US8570167||Jul 24, 2012||Oct 29, 2013||Masimo Corporation||Physiological trend monitor|
|US8570503||Jun 15, 2012||Oct 29, 2013||Cercacor Laboratories, Inc.||Heat sink for noninvasive medical sensor|
|US8571617||Mar 4, 2009||Oct 29, 2013||Glt Acquisition Corp.||Flowometry in optical coherence tomography for analyte level estimation|
|US8577431||Jul 2, 2009||Nov 5, 2013||Cercacor Laboratories, Inc.||Noise shielding for a noninvasive device|
|US8588880||Feb 16, 2010||Nov 19, 2013||Masimo Corporation||Ear sensor|
|US8626255||May 22, 2012||Jan 7, 2014||Cercacor Laboratories, Inc.||Noninvasive multi-parameter patient monitor|
|US8630691||Aug 3, 2009||Jan 14, 2014||Cercacor Laboratories, Inc.||Multi-stream sensor front ends for noninvasive measurement of blood constituents|
|US8641631||Apr 8, 2005||Feb 4, 2014||Masimo Corporation||Non-invasive monitoring of respiratory rate, heart rate and apnea|
|US8666468||May 4, 2011||Mar 4, 2014||Masimo Corporation||Patient monitor for determining microcirculation state|
|US8676286||Jan 3, 2011||Mar 18, 2014||Cercacor Laboratories, Inc.||Method and apparatus for reducing coupling between signals in a measurement system|
|US8688183||Sep 2, 2010||Apr 1, 2014||Ceracor Laboratories, Inc.||Emitter driver for noninvasive patient monitor|
|US8690799||Oct 14, 2010||Apr 8, 2014||Masimo Corporation||Acoustic respiratory monitoring sensor having multiple sensing elements|
|US8700112||Feb 28, 2013||Apr 15, 2014||Masimo Corporation||Secondary-emitter sensor position indicator|
|US8702627||Oct 14, 2010||Apr 22, 2014||Masimo Corporation||Acoustic respiratory monitoring sensor having multiple sensing elements|
|US8706179||May 7, 2012||Apr 22, 2014||Masimo Corporation||Reusable pulse oximeter probe and disposable bandage apparatii|
|US8715206||Oct 14, 2010||May 6, 2014||Masimo Corporation||Acoustic patient sensor|
|US8718737||Apr 2, 2012||May 6, 2014||Masimo Corporation||Method and apparatus for demodulating signals in a pulse oximetry system|
|US8721541||Jan 18, 2013||May 13, 2014||Masimo Corporation||Physiological monitor|
|US8723677||Oct 19, 2011||May 13, 2014||Masimo Corporation||Patient safety system with automatically adjusting bed|
|US8740792||Jul 8, 2011||Jun 3, 2014||Masimo Corporation||Patient monitor capable of accounting for environmental conditions|
|US8754776||Jun 14, 2013||Jun 17, 2014||Cercacor Laboratories, Inc.||Interference detector for patient monitor|
|US8755535||Oct 14, 2010||Jun 17, 2014||Masimo Corporation||Acoustic respiratory monitoring sensor having multiple sensing elements|
|US8755872||Jul 27, 2012||Jun 17, 2014||Masimo Corporation||Patient monitoring system for indicating an abnormal condition|
|US8761850||Dec 21, 2012||Jun 24, 2014||Masimo Corporation||Reflection-detector sensor position indicator|
|US8768423||Mar 4, 2009||Jul 1, 2014||Glt Acquisition Corp.||Multispot monitoring for use in optical coherence tomography|
|US8771204||Dec 21, 2009||Jul 8, 2014||Masimo Corporation||Acoustic sensor assembly|
|US8781543||Mar 26, 2012||Jul 15, 2014||Jpmorgan Chase Bank, National Association||Manual and automatic probe calibration|
|US8781544||Mar 26, 2008||Jul 15, 2014||Cercacor Laboratories, Inc.||Multiple wavelength optical sensor|
|US8781549||Aug 14, 2012||Jul 15, 2014||Cercacor Laboratories, Inc.||Noninvasive oximetry optical sensor including disposable and reusable elements|
|US8788003||Apr 25, 2012||Jul 22, 2014||Glt Acquisition Corp.||Monitoring blood constituent levels in biological tissue|
|US8801613||Dec 3, 2010||Aug 12, 2014||Masimo Corporation||Calibration for multi-stage physiological monitors|
|US8821397||Sep 27, 2011||Sep 2, 2014||Masimo Corporation||Depth of consciousness monitor including oximeter|
|US8821415||Oct 14, 2010||Sep 2, 2014||Masimo Corporation||Physiological acoustic monitoring system|
|US8830449||Apr 17, 2012||Sep 9, 2014||Cercacor Laboratories, Inc.||Blood analysis system|
|US8831700||Jul 9, 2012||Sep 9, 2014||Glt Acquisition Corp.||Apparatus and method for creating a stable optical interface|
|US8840549||Sep 24, 2007||Sep 23, 2014||Masimo Corporation||Modular patient monitor|
|US8847740||Sep 25, 2013||Sep 30, 2014||Masimo Corporation||Alarm suspend system|
|US8852094||Dec 21, 2007||Oct 7, 2014||Masimo Corporation||Physiological parameter system|
|US8868150||Sep 30, 2013||Oct 21, 2014||Cercacor Laboratories, Inc.||Optical sensor including disposable and reusable elements|
|US8870792||Oct 12, 2012||Oct 28, 2014||Masimo Corporation||Physiological acoustic monitoring system|
|US8886271||Jun 17, 2013||Nov 11, 2014||Cercacor Laboratories, Inc.||Non-invasive physiological sensor cover|
|US8888539||Aug 9, 2013||Nov 18, 2014||Masimo Corporation||Shielded connector assembly|
|US8888708||May 14, 2012||Nov 18, 2014||Masimo Corporation||Signal processing apparatus and method|
|US8892180||Jul 29, 2013||Nov 18, 2014||Masimo Corporation||Sine saturation transform|
|US8909310||Jan 13, 2014||Dec 9, 2014||Cercacor Laboratories, Inc.||Multi-stream sensor front ends for noninvasive measurement of blood constituents|
|US8911377||Sep 15, 2009||Dec 16, 2014||Masimo Corporation||Patient monitor including multi-parameter graphical display|
|US8920317||Sep 13, 2013||Dec 30, 2014||Masimo Corporation||Multipurpose sensor port|
|US8921699||Apr 4, 2011||Dec 30, 2014||Masimo Corporation||Low noise oximetry cable including conductive cords|
|US8948835||May 17, 2013||Feb 3, 2015||Cercacor Laboratories, Inc.||Systems and methods for determining blood oxygen saturation values using complex number encoding|
|US8965471||Feb 11, 2013||Feb 24, 2015||Cercacor Laboratories, Inc.||Tissue profile wellness monitor|
|US8983564||Sep 26, 2012||Mar 17, 2015||Masimo Corporation||Perfusion index smoother|
|US8989831||May 18, 2010||Mar 24, 2015||Masimo Corporation||Disposable components for reusable physiological sensor|
|US8996085||Jun 14, 2011||Mar 31, 2015||Masimo Corporation||Robust alarm system|
|US8998809||May 9, 2007||Apr 7, 2015||Cercacor Laboratories, Inc.||Systems and methods for calibrating minimally invasive and non-invasive physiological sensor devices|
|US9028429||Apr 23, 2014||May 12, 2015||Masimo Corporation||Acoustic sensor assembly|
|US9037207||Oct 25, 2013||May 19, 2015||Masimo Corporation||Hemoglobin display and patient treatment|
|US9060721||Oct 25, 2013||Jun 23, 2015||Glt Acquisition Corp.||Flowometry in optical coherence tomography for analyte level estimation|
|US9066680||Oct 15, 2010||Jun 30, 2015||Masimo Corporation||System for determining confidence in respiratory rate measurements|
|US9078560||Nov 2, 2012||Jul 14, 2015||Glt Acquisition Corp.||Method for data reduction and calibration of an OCT-based physiological monitor|
|US9084569||Mar 17, 2014||Jul 21, 2015||Cercacor Laboratories, Inc.||Method and apparatus for reducing coupling between signals in a measurement system|
|US9095316||Apr 19, 2012||Aug 4, 2015||Masimo Corporation||System for generating alarms based on alarm patterns|
|US9107625||May 5, 2009||Aug 18, 2015||Masimo Corporation||Pulse oximetry system with electrical decoupling circuitry|
|US9113831||Sep 25, 2013||Aug 25, 2015||Masimo Corporation||Physiological measurement communications adapter|
|US9113832||Mar 18, 2014||Aug 25, 2015||Masimo Corporation||Wrist-mounted physiological measurement device|
|US9119595||Jun 18, 2014||Sep 1, 2015||Masimo Corporation||Reflection-detector sensor position indicator|
|US9131881||Apr 17, 2013||Sep 15, 2015||Masimo Corporation||Hypersaturation index|
|US9131882||Oct 11, 2013||Sep 15, 2015||Cercacor Laboratories, Inc.||Noninvasive multi-parameter patient monitor|
|US9131883||Oct 28, 2013||Sep 15, 2015||Masimo Corporation||Physiological trend monitor|
|US9131917||Mar 27, 2015||Sep 15, 2015||Masimo Corporation||Acoustic sensor assembly|
|US9138180||May 3, 2011||Sep 22, 2015||Masimo Corporation||Sensor adapter cable|
|US9138182||Oct 29, 2013||Sep 22, 2015||Cercacor Laboratories, Inc.||Optical sensor including disposable and reusable elements|
|US9142117||Nov 13, 2012||Sep 22, 2015||Masimo Corporation||Systems and methods for storing, analyzing, retrieving and displaying streaming medical data|
|US9153112||Mar 2, 2011||Oct 6, 2015||Masimo Corporation||Modular patient monitor|
|US9153121||Aug 26, 2014||Oct 6, 2015||Masimo Corporation||Alarm suspend system|
|US9161696||Dec 17, 2009||Oct 20, 2015||Masimo Corporation||Modular patient monitor|
|US9161713||Dec 20, 2012||Oct 20, 2015||Masimo Corporation||Multi-mode patient monitor configured to self-configure for a selected or determined mode of operation|
|US9167995||Mar 18, 2014||Oct 27, 2015||Cercacor Laboratories, Inc.||Physiological parameter confidence measure|
|US9176141||Oct 15, 2011||Nov 3, 2015||Cercacor Laboratories, Inc.||Physiological monitor calibration system|
|US9186102||Mar 27, 2014||Nov 17, 2015||Cercacor Laboratories, Inc.||Emitter driver for noninvasive patient monitor|
|US9192312||Jan 21, 2014||Nov 24, 2015||Masimo Corporation||Patient monitor for determining microcirculation state|
|US9192329||Oct 12, 2007||Nov 24, 2015||Masimo Corporation||Variable mode pulse indicator|
|US9192351||Jul 20, 2012||Nov 24, 2015||Masimo Corporation||Acoustic respiratory monitoring sensor with probe-off detection|
|US9195385||Mar 25, 2013||Nov 24, 2015||Masimo Corporation||Physiological monitor touchscreen interface|
|US9211072||May 16, 2014||Dec 15, 2015||Masimo Corporation||Disposable active pulse sensor|
|US9211095||Mar 20, 2012||Dec 15, 2015||Masimo Corporation||Physiological measurement logic engine|
|US9218454||Mar 3, 2010||Dec 22, 2015||Masimo Corporation||Medical monitoring system|
|US9226696||May 12, 2014||Jan 5, 2016||Masimo Corporation||Patient safety system with automatically adjusting bed|
|US9241662||Dec 11, 2013||Jan 26, 2016||Cercacor Laboratories, Inc.||Configurable physiological measurement system|
|US9245668||Jun 28, 2012||Jan 26, 2016||Cercacor Laboratories, Inc.||Low noise cable providing communication between electronic sensor components and patient monitor|
|US9259185||Aug 23, 2013||Feb 16, 2016||Masimo Corporation||Ear sensor|
|US9277880||Jul 1, 2010||Mar 8, 2016||Masimo Corporation||Multi-stream data collection system for noninvasive measurement of blood constituents|
|US9289167||Dec 5, 2012||Mar 22, 2016||Masimo Corporation||Signal processing apparatus and method|
|US9295421||Oct 13, 2014||Mar 29, 2016||Masimo Corporation||Non-invasive physiological sensor cover|
|US9307928||Mar 30, 2011||Apr 12, 2016||Masimo Corporation||Plethysmographic respiration processor|
|US9323894||Aug 17, 2012||Apr 26, 2016||Masimo Corporation||Health care sanitation monitoring system|
|US9326712||Jun 2, 2011||May 3, 2016||Masimo Corporation||Opticoustic sensor|
|US9351673||May 5, 2014||May 31, 2016||Masimo Corporation||Method and apparatus for demodulating signals in a pulse oximetry system|
|US9351675||Dec 2, 2014||May 31, 2016||Cercacor Laboratories, Inc.||Noninvasive multi-parameter patient monitor|
|US9370325||May 18, 2015||Jun 21, 2016||Masimo Corporation||Hemoglobin display and patient treatment|
|US9370326||Sep 11, 2012||Jun 21, 2016||Masimo Corporation||Oximeter probe off indicator defining probe off space|
|US9370335||Oct 23, 2014||Jun 21, 2016||Masimo Corporation||Physiological acoustic monitoring system|
|US9386953||Aug 12, 2011||Jul 12, 2016||Masimo Corporation||Method of sterilizing a reusable portion of a noninvasive optical probe|
|US9386961||Aug 29, 2014||Jul 12, 2016||Masimo Corporation||Physiological acoustic monitoring system|
|US9392945||Jan 3, 2013||Jul 19, 2016||Masimo Corporation||Automated CCHD screening and detection|
|US9397448||Oct 20, 2014||Jul 19, 2016||Masimo Corporation||Shielded connector assembly|
|US9408542||Jul 22, 2011||Aug 9, 2016||Masimo Corporation||Non-invasive blood pressure measurement system|
|US9436645||Oct 12, 2012||Sep 6, 2016||Masimo Corporation||Medical monitoring hub|
|US9445759||Dec 24, 2012||Sep 20, 2016||Cercacor Laboratories, Inc.||Blood glucose calibration system|
|US9474474||Mar 4, 2014||Oct 25, 2016||Masimo Corporation||Patient monitor as a minimally invasive glucometer|
|US9480435||Feb 8, 2013||Nov 1, 2016||Masimo Corporation||Configurable patient monitoring system|
|US9492110||May 12, 2014||Nov 15, 2016||Masimo Corporation||Physiological monitor|
|US9510779||Sep 16, 2010||Dec 6, 2016||Masimo Corporation||Analyte monitoring using one or more accelerometers|
|US9517024||Sep 5, 2014||Dec 13, 2016||Masimo Corporation||Optical-based physiological monitoring system|
|US9532722||Jun 19, 2012||Jan 3, 2017||Masimo Corporation||Patient monitoring system|
|US9538949||Aug 27, 2014||Jan 10, 2017||Masimo Corporation||Depth of consciousness monitor including oximeter|
|US9538980||Apr 7, 2014||Jan 10, 2017||Masimo Corporation||Acoustic respiratory monitoring sensor having multiple sensing elements|
|US9549696||Sep 21, 2015||Jan 24, 2017||Cercacor Laboratories, Inc.||Physiological parameter confidence measure|
|US9554737||Sep 25, 2013||Jan 31, 2017||Masimo Corporation||Noninvasively measuring analyte levels in a subject|
|US9560996||Oct 30, 2013||Feb 7, 2017||Masimo Corporation||Universal medical system|
|US9560998||Aug 7, 2015||Feb 7, 2017||Masimo Corporation||System and method for monitoring the life of a physiological sensor|
|US9566019||Jan 13, 2014||Feb 14, 2017||Masimo Corporation||Respiratory monitoring|
|US9579039||Jan 10, 2012||Feb 28, 2017||Masimo Corporation||Non-invasive intravascular volume index monitor|
|US9591975||May 6, 2013||Mar 14, 2017||Masimo Corporation||Contoured protrusion for improving spectroscopic measurement of blood constituents|
|US9622692||May 16, 2012||Apr 18, 2017||Masimo Corporation||Personal health device|
|US9622693||Jan 30, 2015||Apr 18, 2017||Masimo Corporation||Systems and methods for determining blood oxygen saturation values using complex number encoding|
|US9636055||Oct 24, 2011||May 2, 2017||Masimo Corporation||Pulse and confidence indicator displayed proximate plethysmograph|
|US9636056||Apr 10, 2015||May 2, 2017||Masimo Corporation||Physiological trend monitor|
|US9649054||Aug 25, 2011||May 16, 2017||Cercacor Laboratories, Inc.||Blood pressure measurement method|
|US9662052||Nov 13, 2013||May 30, 2017||Masimo Corporation||Reprocessing of a physiological sensor|
|US9668679||Jun 11, 2015||Jun 6, 2017||Masimo Corporation||Method for data reduction and calibration of an OCT-based physiological monitor|
|US9668680||Nov 16, 2015||Jun 6, 2017||Masimo Corporation||Emitter driver for noninvasive patient monitor|
|US9675286||Aug 2, 2011||Jun 13, 2017||Masimo Corporation||Plethysmograph pulse recognition processor|
|US9687160||May 31, 2013||Jun 27, 2017||Masimo Corporation||Congenital heart disease monitor|
|US9693719||Jul 15, 2014||Jul 4, 2017||Masimo Corporation||Noninvasive oximetry optical sensor including disposable and reusable elements|
|US9693737||Dec 11, 2015||Jul 4, 2017||Masimo Corporation||Physiological measurement logic engine|
|US9697928||Jul 25, 2013||Jul 4, 2017||Masimo Corporation||Automated assembly sensor cable|
|US9717425||Nov 1, 2013||Aug 1, 2017||Masimo Corporation||Noise shielding for a noninvaise device|
|US9717458||Oct 17, 2013||Aug 1, 2017||Masimo Corporation||Magnetic-flap optical sensor|
|US9724016||Oct 15, 2010||Aug 8, 2017||Masimo Corp.||Respiration processor|
|US9724024||Feb 28, 2011||Aug 8, 2017||Masimo Corporation||Adaptive alarm system|
|US9724025||Jul 10, 2014||Aug 8, 2017||Masimo Corporation||Active-pulse blood analysis system|
|US9730640||Sep 10, 2013||Aug 15, 2017||Masimo Corporation||Pulse oximeter probe-off detector|
|US9749232||Sep 18, 2013||Aug 29, 2017||Masimo Corporation||Intelligent medical network edge router|
|US9750442||Mar 10, 2014||Sep 5, 2017||Masimo Corporation||Physiological status monitor|
|US9750443||Aug 29, 2014||Sep 5, 2017||Cercacor Laboratories, Inc.||Multiple wavelength sensor emitters|
|US9750461||Dec 20, 2013||Sep 5, 2017||Masimo Corporation||Acoustic respiratory monitoring sensor with probe-off detection|
|US20100217103 *||Feb 16, 2010||Aug 26, 2010||Yassir Abdul-Hafiz||Ear sensor|
|USD755392||Feb 6, 2015||May 3, 2016||Masimo Corporation||Pulse oximetry sensor|
|USD788312||Aug 24, 2015||May 30, 2017||Masimo Corporation||Wireless patient monitoring device|
|USRE44823||Feb 7, 2012||Apr 1, 2014||Masimo Corporation||Universal modular pulse oximeter probe for use with reusable and disposable patient attachment devices|
|U.S. Classification||600/316, 600/322|
|International Classification||A61B5/00, A61B5/1455|
|Cooperative Classification||A61B5/14532, A61B2560/0462, A61B5/6826, A61B5/1455, A61B5/6838, A61B5/14552|
|European Classification||A61B5/1455, A61B5/145G, A61B5/1455N2, A61B5/68B3L, A61B5/68B2J1|
|May 11, 2012||AS||Assignment|
Owner name: CERCACOR LABORATORIES, INC., CALIFORNIA
Free format text: CHANGE OF NAME;ASSIGNOR:MASIMO LABORATORIES, INC.;REEL/FRAME:028192/0453
Effective date: 20100802
|Jun 19, 2012||CC||Certificate of correction|
|Mar 9, 2016||AS||Assignment|
Owner name: MASIMO CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CERCACOR LABORATORIES, INC.;REEL/FRAME:038049/0074
Effective date: 20160308