WO1983003347A1 - Vascular prosthesis - Google Patents

Vascular prosthesis Download PDF

Info

Publication number
WO1983003347A1
WO1983003347A1 PCT/GB1983/000088 GB8300088W WO8303347A1 WO 1983003347 A1 WO1983003347 A1 WO 1983003347A1 GB 8300088 W GB8300088 W GB 8300088W WO 8303347 A1 WO8303347 A1 WO 8303347A1
Authority
WO
WIPO (PCT)
Prior art keywords
prosthesis
extended
markings
lines
vascular
Prior art date
Application number
PCT/GB1983/000088
Other languages
French (fr)
Inventor
Limited J. & P. Coats
Original Assignee
Hood, Robert, Gordon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hood, Robert, Gordon filed Critical Hood, Robert, Gordon
Priority to JP58501096A priority Critical patent/JPS59500452A/en
Priority to DE8383900953T priority patent/DE3362149D1/en
Priority to AT83900953T priority patent/ATE17995T1/en
Publication of WO1983003347A1 publication Critical patent/WO1983003347A1/en
Priority to DK531783A priority patent/DK531783A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L11/00—Hoses, i.e. flexible pipes
    • F16L11/04—Hoses, i.e. flexible pipes made of rubber or flexible plastics
    • F16L11/11—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall
    • F16L11/118—Hoses, i.e. flexible pipes made of rubber or flexible plastics with corrugated wall having arrangements for particular purposes, e.g. electrically conducting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937—Visible markers

Definitions

  • the subject of this invention is a vascular prosthesis of the type comprising a porous tube made of textile material formed with circumferential corrugations intended to act as a substitute blood vessel in a human or an animal body.
  • a vascular prosthesis In placing a vascular prosthesis in position in a human or animal body it is extremely desirable that the graft should not be twisted. To this end it is known to provide on the graft at least one line of contrasting colour so that any twist in the graft becomes readily apparent.
  • there is another consideration relating to the fitting of a graft That is that the amount by which the graft is extended axially beyond its unstressed condition should be maintained within a predetermined limit. If the graft is not stretched far enough there may be an increased resistance presented to the flow of blood through the graft because of interference presented by the corrugations.
  • the pores may be extended to a point where there is a danger of haemorrhage occurring at the junction between the graft and the host tissue before there has been time for the build up of tissue on the walls of the graft or the sutures at the junction may be pulled out of the host tissue if excessive stretch as a result of excessive tension in the graft itself.
  • a vascular prosthesis according to the invention comprises a corrugated tube of textile material characterized by presenting- a pattern of a series of separate axially disposed markings on the corrugations, the disposition of the .markings being such that when the prosthesis is extended to about the predetermined correct degree of extension whereby to increase the angle between opposite sides of each corrugation the observed pattern of markings along the prosthesis changes to provide a signal that the correct degree of extension has been attained.
  • a short axial line on each crest and/or in each trough,there is provided a short axial line, so disposed that when the prosthesis is extended to the predetermined proper extent the individual lines are in alignment and show gaps between adjacent lines the projected lengths of which to an observer are a readily discernible proportion of the length of each line.
  • the proportion is a proportion of equality i.e. the lengths of the gaps appear to be the same as the lengths of the individual lines thus providing a dashed line from one end of the prosthesis to the other with the lengths of lines and spaces all . equal.
  • the prosthesis may be marked with spaced circumferential lines each of which forms a short arc on the surface of the prosthesis, the axial positioning and spacing of the lines being such that when the prosthesis is extended by the desirable amount the arcs when viewed from one side of the prosthesis are spaced in a predetermined relation to one another, once again preferably equi-distantly from one another.
  • the arcs may be so positioned that .when the prosthesis is in the unstressed state the arcs appear in groups of closely spaced lines and when the prosthesis is extended to the desirable extent the radially projected lengths of the gaps between all the arcs become equal to an observer.
  • the markings are in the form of geometrical shapes which - .5 -
  • the prosthesis in the unstressed state of the prosthesis have one. form and when the prosthesis " is extended change to another readily distinguishable geometrical shape.
  • the prosthesis may bear marks which appear as diamonds or elipses when the prosthesis is unextended and which appear as squares or circles respectively when the prosthesis is extended to the desirable extent.
  • Fig. 1 illustrates a vascular prosthesis in the unstressed condition indicating in side elevation the manner in which the individual axial lines are applied to the prosthesis
  • Fig. 2 shows how the prosthesis appears in the unextended condition looking down into the corrugations and showing the appearance of the markings
  • Fig. 3 shows the prosthesis of Figs. 1 and 2 extended to the desirable amount indicating how the markings then appear.
  • Fig. 4 illustrates a prosthesis with another form of marking in the form of arcs orientated circumferentially on the prosthesis
  • Fig. 5 illustrates how the prosthesis of Fig. 4 appears when looked at in the unextended condition
  • Fig. 6 illustrates the prosthesis of Figs.
  • FIG. 7 illustrates a prosthesis with yet another form of marking in the form of a line of diagonally disposed squares
  • Fig. 8 illustrates how the prosthesis appears in the unextended position looking down into the corrugations
  • Fig. 9 shows the prosthesis of Figs. 7 and 8 extended to the desirable amount.
  • FIG. 1 denotes the prosthesis formed with corrugations 2.
  • the numeral 3 denotes axially orientated lines marked on the tube constituting the prosthesis while in Figs. 4, 5 and 6 , the numeral 4 denotes arcuate lines marked on the tube constituting the prosthesis.
  • the numeral 5 indicates squares marked on the tube constituting the prosthesis.
  • the prosthesis appears as illustrated in Fig. 2 with the lines marked thereon indicating a more or less continuous line or at least with gaps between adjacent lines much smaller than the lengths of the lines themselves.
  • the angle between the sides of each corrugation is increased so that the radially projected length of each line or each space as the case may be as seen by an observer is changed to show a dashed line along the length of the prosthesis in which the individual lines an spaces are of equal length.
  • the unextended prosthesis appears as in Fig. 5 with the lines appearing in groups in which the spacing is irregular.
  • the projected distance between adjacent lines is changed because of the change in angularity of the surface carrying the lines and they appear all equi-spaced in an axial direction.

Abstract

A vascular prosthesis intended to act as a substitute blood vessel comprises a porous corrugated tube (1) of textile material presenting a pattern of a series of axially disposed markings on the corrugations (2) so disposed that the appearance of the pattern changes when the prosthesis is extended. The change in the appearance of the pattern as the tube is extended provides an indication to the user when the prosthesis has been extended to the desirable extent.

Description

VASCULAR PROSTHESIS
The subject of this invention is a vascular prosthesis of the type comprising a porous tube made of textile material formed with circumferential corrugations intended to act as a substitute blood vessel in a human or an animal body.
In placing a vascular prosthesis in position in a human or animal body it is extremely desirable that the graft should not be twisted. To this end it is known to provide on the graft at least one line of contrasting colour so that any twist in the graft becomes readily apparent. However, there is another consideration relating to the fitting of a graft. That is that the amount by which the graft is extended axially beyond its unstressed condition should be maintained within a predetermined limit. If the graft is not stretched far enough there may be an increased resistance presented to the flow of blood through the graft because of interference presented by the corrugations. If the graft is stretched too much the pores may be extended to a point where there is a danger of haemorrhage occurring at the junction between the graft and the host tissue before there has been time for the build up of tissue on the walls of the graft or the sutures at the junction may be pulled out of the host tissue if excessive stretch as a result of excessive tension in the graft itself.
It is an object of the present invention to provide an indicating means on the graft which will indicate to the surgeon who is implanting the graft not only whether the graft is straight but also when the correct amount of extension has been attained.
A vascular prosthesis according to the invention comprises a corrugated tube of textile material characterized by presenting- a pattern of a series of separate axially disposed markings on the corrugations, the disposition of the .markings being such that when the prosthesis is extended to about the predetermined correct degree of extension whereby to increase the angle between opposite sides of each corrugation the observed pattern of markings along the prosthesis changes to provide a signal that the correct degree of extension has been attained.
In one construction, on each crest and/or in each trough,there is provided a short axial line, so disposed that when the prosthesis is extended to the predetermined proper extent the individual lines are in alignment and show gaps between adjacent lines the projected lengths of which to an observer are a readily discernible proportion of the length of each line.
Preferably the proportion is a proportion of equality i.e. the lengths of the gaps appear to be the same as the lengths of the individual lines thus providing a dashed line from one end of the prosthesis to the other with the lengths of lines and spaces all. equal.
Alternatively the prosthesis may be marked with spaced circumferential lines each of which forms a short arc on the surface of the prosthesis, the axial positioning and spacing of the lines being such that when the prosthesis is extended by the desirable amount the arcs when viewed from one side of the prosthesis are spaced in a predetermined relation to one another, once again preferably equi-distantly from one another.
The arcs may be so positioned that .when the prosthesis is in the unstressed state the arcs appear in groups of closely spaced lines and when the prosthesis is extended to the desirable extent the radially projected lengths of the gaps between all the arcs become equal to an observer.
In a still further alternative arrangement the markings are in the form of geometrical shapes which - .5 -
in the unstressed state of the prosthesis have one. form and when the prosthesis "is extended change to another readily distinguishable geometrical shape. For example the prosthesis may bear marks which appear as diamonds or elipses when the prosthesis is unextended and which appear as squares or circles respectively when the prosthesis is extended to the desirable extent.
Practical embodiments of the invention are illustrated in the accompanying drawings in which
Fig. 1 illustrates a vascular prosthesis in the unstressed condition indicating in side elevation the manner in which the individual axial lines are applied to the prosthesis, Fig. 2 shows how the prosthesis appears in the unextended condition looking down into the corrugations and showing the appearance of the markings and Fig. 3 shows the prosthesis of Figs. 1 and 2 extended to the desirable amount indicating how the markings then appear. Fig. 4 illustrates a prosthesis with another form of marking in the form of arcs orientated circumferentially on the prosthesis, Fig. 5 illustrates how the prosthesis of Fig. 4 appears when looked at in the unextended condition and Fig. 6 illustrates the prosthesis of Figs. 4 and 5 extended 'to the desirable amount showing the markings clearly indicating that this situation has been reached by the equal spacing of the markings. Fig. 7 illustrates a prosthesis with yet another form of marking in the form of a line of diagonally disposed squares, Fig. 8 illustrates how the prosthesis appears in the unextended position looking down into the corrugations and Fig. 9 shows the prosthesis of Figs. 7 and 8 extended to the desirable amount.
In the drawings 1 denotes the prosthesis formed with corrugations 2. In Figs. 1, 2 and 3, the numeral 3 denotes axially orientated lines marked on the tube constituting the prosthesis while in Figs. 4, 5 and 6 , the numeral 4 denotes arcuate lines marked on the tube constituting the prosthesis. In Figs. 7, 8 and 9 the numeral 5 indicates squares marked on the tube constituting the prosthesis.
Referring first to the construction of
Figs. 1, 2 and 3, the prosthesis appears as illustrated in Fig. 2 with the lines marked thereon indicating a more or less continuous line or at least with gaps between adjacent lines much smaller than the lengths of the lines themselves. When the prosthesis is extended to the most desirable extent for use as a graft the angle between the sides of each corrugation is increased so that the radially projected length of each line or each space as the case may be as seen by an observer is changed to show a dashed line along the length of the prosthesis in which the individual lines an spaces are of equal length.
In the construction of Figs. 4, 5 and 6 , the unextended prosthesis appears as in Fig. 5 with the lines appearing in groups in which the spacing is irregular. When the prosthesis is extended to the desirable extent for use as a graft once again the projected distance between adjacent lines is changed because of the change in angularity of the surface carrying the lines and they appear all equi-spaced in an axial direction.
In the construction of Figs. 7, 8 and 9 the unextended prosthesis appears as in Fig. 7 with the squares appearing as transversely orientated diamonds. When the prosthesis is extended to the desirable extent the diamond shapes appear as squares or quasi-squares.
I *TΓBJEA7Γ
OMPI

Claims

1. A vascular prosthesis which comprises a corrugated t"be (1) of textile material is characterized by presenting a pattern of a series of .separate axially disposed markings (3 or 4 or 5) on the corrugations (2) , the disposition of the markings being such that when the prosthesis is extended to about the predetermined correct degree of extension whereby to increase the angle between opposite sides of each corrugation the observed pattern of markings along the prosthesis changes to provide a signal that the correct degree of extension has been attained.
2. A vascular prosthesis according to claim 1 characterized in that on each crest and/or in each trough of each corrugation t.her"e is provided a short axial line (3) so disposed that when the prosthesis is extended to the predetermined proper extent the individual lines are in alignment and show gaps between adjacent lines the projected lengths of which to an observer are a readily discernible proportion of the length of each line.
3. ' A vascular prosthesis according to claim 1 characterized in that the corrugations (2) are marked with spaced circumferential lines (4) each of which forms a short arc on the surface of the prosthesis, the axial positioning and spacing of the lines being such that when the prosthesis is extended by the desirable amount the arcs when viewed from one side of the prosthesis are spaced in a predetermined relation to one another.
4. A vascular prosthesis according to claim 1 characterized in that the markings are in the form of geometrical shapes which in the unstressed state of the prosthesis have one form and when the prosthesis is extended change to another readily distinguishable geometrical shape.
5. A vascular prosthesis according to claim 4 characterized in that the markj.ngs appear as diamonds (5) when the prosthesis is unextended and which appear as squares when the prosthesis is extended to the desirable extent.
OMPI ,<! WIPO
PCT/GB1983/000088 1982-03-25 1983-03-24 Vascular prosthesis WO1983003347A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP58501096A JPS59500452A (en) 1982-03-25 1983-03-24 blood vessel substitute
DE8383900953T DE3362149D1 (en) 1982-03-25 1983-03-24 Vascular prosthesis
AT83900953T ATE17995T1 (en) 1982-03-25 1983-03-24 VESSEL PROSTHESIS.
DK531783A DK531783A (en) 1982-03-25 1983-11-21 vascular graft

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8208852 1982-03-25
GB8208852820325 1982-03-25

Publications (1)

Publication Number Publication Date
WO1983003347A1 true WO1983003347A1 (en) 1983-10-13

Family

ID=10529285

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1983/000088 WO1983003347A1 (en) 1982-03-25 1983-03-24 Vascular prosthesis

Country Status (10)

Country Link
US (1) US4545082A (en)
EP (1) EP0104198B1 (en)
JP (1) JPS59500452A (en)
CA (1) CA1195806A (en)
DE (1) DE3362149D1 (en)
DK (1) DK531783A (en)
ES (1) ES520936A0 (en)
GR (1) GR77865B (en)
IT (2) IT1171813B (en)
WO (1) WO1983003347A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5697970A (en) * 1994-08-02 1997-12-16 Meadox Medicals, Inc. Thinly woven flexible graft
WO2012076712A1 (en) * 2010-12-09 2012-06-14 Sofradim Production Prosthesis with zigzag seam

Families Citing this family (39)

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US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US5759830A (en) * 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
IT1202558B (en) * 1987-02-17 1989-02-09 Alberto Arpesani INTERNAL PROSTHESIS FOR THE REPLACEMENT OF A PART OF THE HUMAN BODY PARTICULARLY IN THE VASCULAR OPERATIONS
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5476506A (en) * 1994-02-08 1995-12-19 Ethicon, Inc. Bi-directional crimped graft
US5609627A (en) * 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US6051020A (en) 1994-02-09 2000-04-18 Boston Scientific Technology, Inc. Bifurcated endoluminal prosthesis
US6165213A (en) * 1994-02-09 2000-12-26 Boston Scientific Technology, Inc. System and method for assembling an endoluminal prosthesis
EP1520557A3 (en) 1994-06-08 2010-07-21 Cardiovascular Concepts, Inc. Apparatus and methods for endoluminal graft placement
US5683451A (en) * 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
US5500902A (en) * 1994-07-08 1996-03-19 Stockham, Jr.; Thomas G. Hearing aid device incorporating signal processing techniques
US8085959B2 (en) 1994-07-08 2011-12-27 Brigham Young University Hearing compensation system incorporating signal processing techniques
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
US5895424A (en) * 1996-11-12 1999-04-20 Mentor Corporation Prosthesis having an alignment indicator and method of using same
US7500988B1 (en) * 2000-11-16 2009-03-10 Cordis Corporation Stent for use in a stent graft
US6887268B2 (en) * 1998-03-30 2005-05-03 Cordis Corporation Extension prosthesis for an arterial repair
US6723133B1 (en) 1998-09-11 2004-04-20 C. R. Bard, Inc. Performed curved prosthesis having a reduced incidence of developing wrinkles or folds
US6740122B1 (en) 1998-09-11 2004-05-25 C. R. Bard, Inc. Preformed curved prosthesis that is adapted to the external iliac vessels
US6287335B1 (en) * 1999-04-26 2001-09-11 William J. Drasler Intravascular folded tubular endoprosthesis
US6409757B1 (en) * 1999-09-15 2002-06-25 Eva Corporation Method and apparatus for supporting a graft assembly
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US20050288775A1 (en) * 2004-06-24 2005-12-29 Scimed Life Systems, Inc. Metallic fibers reinforced textile prosthesis
EP1991164B1 (en) 2006-02-28 2017-06-14 Angiomed GmbH & Co. Medizintechnik KG Flexible stretch stent-graft
WO2010128469A1 (en) 2009-05-05 2010-11-11 Deliverance Ltd. Device for sealing perforations and sustaining flow
SG186837A1 (en) 2010-03-01 2013-02-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
AU2011276503B2 (en) 2010-06-28 2015-09-17 Colibri Heart Value LLC Method and apparatus for the endoluminal delivery of intravascular devices
SG10201601962WA (en) 2010-12-14 2016-04-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
WO2018039651A1 (en) * 2016-08-26 2018-03-01 Healionics Corporation Corrugated microporous tissue interface for improved performance and infection resistance of vascular grafts and other implantable devices
EP3668451A1 (en) 2017-08-17 2020-06-24 Incubar LLC Prosthetic vascular valve and methods associated therewith
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC Conduit vascular implant sealing device for reducing endoleak
US11413129B2 (en) 2020-06-19 2022-08-16 Davol Inc. Implantable prosthesis

Citations (1)

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FR2194406A1 (en) * 1972-07-28 1974-03-01 Meadox Medicals Inc

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US4047252A (en) * 1976-01-29 1977-09-13 Meadox Medicals, Inc. Double-velour synthetic vascular graft
US4193137A (en) * 1977-05-06 1980-03-18 Meadox Medicals, Inc. Warp-knitted double-velour prosthesis
SU860761A1 (en) * 1978-12-11 1981-09-07 Ленинградский Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Технологический Институт Им.Ленсовета Method of manufacturing blood vessel prosthesis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2194406A1 (en) * 1972-07-28 1974-03-01 Meadox Medicals Inc

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5697970A (en) * 1994-08-02 1997-12-16 Meadox Medicals, Inc. Thinly woven flexible graft
USRE40404E1 (en) 1994-08-02 2008-06-24 Maquet Cardiovascular, Llp Thinly woven flexible graft
WO2012076712A1 (en) * 2010-12-09 2012-06-14 Sofradim Production Prosthesis with zigzag seam
FR2968537A1 (en) * 2010-12-09 2012-06-15 Sofradim Production PROTHESIS WITH SEWING IN ZIG-ZAG
US10028815B2 (en) 2010-12-09 2018-07-24 Sofradim Production Prosthesis with zigzag seam

Also Published As

Publication number Publication date
IT8335709V0 (en) 1983-03-25
ES8403313A1 (en) 1984-03-16
JPS59500452A (en) 1984-03-22
EP0104198B1 (en) 1986-02-19
GR77865B (en) 1984-09-25
DK531783D0 (en) 1983-11-21
DE3362149D1 (en) 1986-03-27
CA1195806A (en) 1985-10-29
ES520936A0 (en) 1984-03-16
EP0104198A1 (en) 1984-04-04
US4545082A (en) 1985-10-08
DK531783A (en) 1983-11-21
IT1171813B (en) 1987-06-10
IT8347994A0 (en) 1983-03-25

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