WO1989005651A1 - Therapeutical compositions against psoriasis - Google Patents

Therapeutical compositions against psoriasis Download PDF

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Publication number
WO1989005651A1
WO1989005651A1 PCT/HU1987/000060 HU8700060W WO8905651A1 WO 1989005651 A1 WO1989005651 A1 WO 1989005651A1 HU 8700060 W HU8700060 W HU 8700060W WO 8905651 A1 WO8905651 A1 WO 8905651A1
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WO
WIPO (PCT)
Prior art keywords
officinalis
cortex
calendula
veronica
garlic
Prior art date
Application number
PCT/HU1987/000060
Other languages
French (fr)
Inventor
Ferenc HORVÁTH
Original Assignee
Psoricur Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psoricur Ltd. filed Critical Psoricur Ltd.
Priority to EP88900470A priority Critical patent/EP0364442B1/en
Priority to US07/397,429 priority patent/US5165932A/en
Priority to KR1019890701570A priority patent/KR900700117A/en
Priority to JP63500599A priority patent/JPH0653672B2/en
Priority to AU10539/88A priority patent/AU610551B2/en
Priority to DE8888900470T priority patent/DE3784522T2/en
Priority to AT88900470T priority patent/ATE86114T1/en
Priority to PCT/HU1987/000060 priority patent/WO1989005651A1/en
Priority to MC87HU8700060D priority patent/MC2056A1/en
Priority to IL88659A priority patent/IL88659A/en
Priority to BG86509A priority patent/BG50491A3/en
Priority to ZA889484A priority patent/ZA889484B/en
Priority to CS888632A priority patent/CS277019B6/en
Priority to DD88323714A priority patent/DD277210A5/en
Priority to PL88276650A priority patent/PL276650A1/en
Priority to CN88108776A priority patent/CN1025002C/en
Priority to CA000586781A priority patent/CA1319324C/en
Publication of WO1989005651A1 publication Critical patent/WO1989005651A1/en
Priority to NO893330A priority patent/NO178844C/en
Priority to FI893920A priority patent/FI95200C/en
Priority to DK415889A priority patent/DK415889D0/en
Priority to HR930299A priority patent/HRP930299A2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/50—Fumariaceae (Fumitory family), e.g. bleeding heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the present invention relates to therapeutical compositions on medicinal herb basis for the treatment of psoriasis .
  • An other object of the invention is the preparation of the said compositions .
  • a further object of the invention is the use of the medicinal herbs as listed below in the treatment of psoriasis , rheumatism and asthmatic dyspnoea.
  • P soriasis constitutes one of the most common chronic skin diseases, Even nowdays the origin thereof has not been clarified, pre sumably it is based on a complex effect of various factors within the human organism. In pathological point of view it is a chronic dermatitis , with unnaturally high epithelial cell proliferation on the surface , and hyperaemia and dense lymphocita-infiltration on the corium side . Essentially, the disease may start in any period of life and exists for decades with periodic eruptions and/or permanent centres . P soriasis most frequently occurs on the tensive surfaces of limbs , on hairy scalp and traumatic skin parts , respectively.
  • vitamins B 12 or A different creams containing arsenic acid or arsenates, cooling ointments containing aluminum acetate , desquamatorles with resorcine as active ingredient, lotions containing tallium acetate , as well as other compositions which contain salycilic acid or the derivatives thereof.
  • the ointment P soriasin contains 2,2 ' -dichlorodiethylsulfide /mustardgas/, the said ointment may be used, however, only once daily as a thin, smear.
  • the tar ointments have the disadvantage that only a part of the skin area may be treated once and even with a short contact period.
  • the salycilic acid compositions serve for a desquamation of the skin surface and as such they are again of symptomatic effect only as the disease will not be terminated.
  • the present invention aims to provide a composition which not only serves for symptomatic treatment of psoriasis , but also suppresses the same finally or at least for a long period.
  • the invention is based on the recognition that some combinations of medicinal herbs when used externally on the skin, provide a method of treatment and therapeutical composition, respectively, which fulfil the requirements as aimed above.
  • the present invention provides therapeutical compositions against psoriasis which comprises a combination of different medicinal herbs. Another object of the invention is the process for preparing the above therapeutical compositions . Another object of the present invention is the use of certain combinations of medical herbs in the treatment of psoriasis , rheumatic symptoms and asthmatic dyspnoea.
  • the therapeutical compositions comprise the extracts of the following drug plants: Allium sativum /garlic /, Urtica dioica /common nettle / , Chelidonium ma jus /milkweed/, Veronica officinalis /veronica/ , Calendula officinalis /calendula or marigold/ ,
  • compositions according to the pre sent invention comprise suitably the extracts of at least three of the above medical herbs .
  • the garlic In the natural therapy the garlic is especially used against senescense symptoms, arteriosclerosis , hypertonia, diarrhoea , intestinal worms, etc.
  • the juice thereof is said to be effective against warts as well.
  • the plant comprises garlic oil, alliin and allicin as pharmacologically active ingredients .
  • the latter may be regarded as antibiotic but possesse s insecticidal effect as well.
  • the main amount of the common nettle drug is used in the preparation of chlorophyll.
  • the tea thereof is used against rheumatism, gout, diabetes , oedema, urticaria, catarrhal cystitis , hypertonia , gastroenteritis , exanthems , renal gravel , etc .
  • it has the use against haemorrhoid as sitting bath, against exanthems as lotion , against psilosis , seborrhea and oily hair as hair wash .
  • the milkweed belongs to the family of Papaveraceae .
  • the drug thereof is used in the preparation of medicines against bilious and liver disorders , as well as gastroenteritis also in industrial scale .
  • the fresh juice of the plant serves for treating warts and corns .
  • the tea of veronica is known as antitussive and against asthma and cardiac asthma.
  • calendula may be used internally against gastric and intestinal ulcer and externally for packing of slowly healing wounds and ulcers . It is also known as colouring agent in foodstuffs, medicine a nd drinks.
  • the drugs of yarrow are appetizers and digestives. They can be used as antic ⁇ nvulsiva for promoting the bile and liver function, in the treatment of ureteral and respiratory disorders and as hypotensive agents , respectively. Externally, the concoction thereof is useful wash and lotion against gingival, ocular and general inflammations.
  • the tea of fumitory has appetizing, digestive, laxative and choleretic effect. It is used against icterus as well.
  • compositions according to the present invention comprise suitably at least three of the extracts of the above drug plants.
  • the therapeutical compositions may also contain more than three active ingredients, e. g. all the seven as well.
  • the extracts of the above medicinal herbs are preferably those prepared with an oil.
  • oil vegetable, animal and mineral oils can be used.
  • paraffin oil or sunflower oil is used.
  • the composition according to the present invention are prepared preferably in a form suitable for the treatment of skin.
  • the oily extract of the medicinal herbs itself or the mixture thereof with at least one additive generally used in the preparation of external topical compositions may be used.
  • Especiall preferred additive is the paraffin oil which may be of medical grade /PH. HG . VII/ or cosmetic grade as well.
  • the compositions according to the present invention may also contain further additives known per se , e. g. colouring agents, flavouring agents , etc.
  • flavouring and colouring agents not only the additives generally used by the pharmaceutical industry, but also additional medical herb extracts can be used.
  • medical herbs are e . g. the followings: Calami rhizoma /sweet-sedge /, Quercus cortex /oak-bark/, Salix alba /cortex/ /willow cortex /, Taraxi radix /daudelion/ /cortex/, Alcanae radix /alkanna/.
  • the preparation of the therapeutical compositions is accomplished preferably by pouring the suitable extraction oil on the appropriately crushed, preferably ground dry medical herb , and keeping the mixture on elevated temperature for a longer period. Afterwards the supernatant is separated from the solid plant residue and the supernatant is used for the treatment as such or for mixing with additional additives to prepare therapeutical compositions . In case when besides the active ingredients medical herbs are also used as additives, it is preferred to introduce the latter in the extraction step.
  • the period and temperature of the extraction procedure is not critical, any temperature which does not result in thermal degradation of the active substances in the drugs may be used while the extraction period should be long enough to provide a reasonable extraction grade at the temperature used. Preferably the extraction is carried out for 12 to 48 hours , at a temperature of 40 to 70 °C .
  • the extraction is carried out for 24 hours at 60 °C .
  • the alcoholic extraction of garlic can be carried out with any liquid alcohol, preferably methanol and ethanol.
  • the use of 96 % ethanol is mo st preferred .
  • the temperature and period of the alcoholic extraction is not critical, it can be carried out preferably below or on the boiling point of the alcohol used therein.
  • the extraction is preferably carried out also at 60 °C for 24 hours under continuous stirring.
  • the alcohol is removed from the solid material, preferably by filtering, the solids are dried, preferably in vacuo at 50 to 60 oC and then added to the dry material of the oil extraction.
  • Another object of the present invention is the use of the above medical herbs , the mixtures thereof and the compositions containing the same in tne treatment of rheumatism and asthmatic dyspnoea.
  • any of the seven major components may be present in 0 to 60 % of the total dry weight of active ingredients.
  • the garlic may be present even in a higher concentration, i. e. up to 90 %.

Abstract

The invention relates to therapeutical compositions on medical herb basis for the treatment of psoriasis and the preparation of the same. A further object of the invention is the use of medical herbs as listed below in the treatment of psoriasis, rheumatism and asthmatic dyspnoea. The medical herbs used in the invention are as follows: Allium sativum(garlic), Urtica dioica(common nettle), Chelidonium majus(milkweed), Veronica officinalis(veronica), Calendula officinalis(calendula or marigold), Achillea herba(millefolium) (yarrow), Fumaria officinalis(fumitory, earth-gall).

Description

THERAPEUT ICAL COMPOSITION S AGAINST P SOR IASIS
Technical field
The present invention relates to therapeutical compositions on medicinal herb basis for the treatment of psoriasis . An other object of the invention is the preparation of the said compositions . A further object of the invention is the use of the medicinal herbs as listed below in the treatment of psoriasis , rheumatism and asthmatic dyspnoea.
Background art
P soriasis constitutes one of the most common chronic skin diseases, Even nowdays the origin thereof has not been clarified, pre sumably it is based on a complex effect of various factors within the human organism. In pathological point of view it is a chronic dermatitis , with unnaturally high epithelial cell proliferation on the surface , and hyperaemia and dense lymphocita-infiltration on the corium side . Essentially, the disease may start in any period of life and exists for decades with periodic eruptions and/or permanent centres . P soriasis most frequently occurs on the tensive surfaces of limbs , on hairy scalp and traumatic skin parts , respectively.
A large number of methods have already been used for the treatment of psoriasis . B . Issekutz and L . Issekutz, Gyόgyszerrendeles , Medicina , Budapest, 1979 gives a comprehensive review on the methods and materials used for the treatment of psoriasis . These treatments are , however, almost exclusively of symptomatic character only as no composition against psoriasis has been provided which would result in a total curative effect or at least in a suppression of the disease for a longer period , i. e . for some years . The literature suggests for the treatment of psoriasis e. g. vitamins B12 or A , different creams containing arsenic acid or arsenates, cooling ointments containing aluminum acetate , desquamatorles with resorcine as active ingredient, lotions containing tallium acetate , as well as other compositions which contain salycilic acid or the derivatives thereof. The ointment P soriasin contains 2,2 ' -dichlorodiethylsulfide /mustardgas/, the said ointment may be used, however, only once daily as a thin, smear. The tar ointments have the disadvantage that only a part of the skin area may be treated once and even with a short contact period. The salycilic acid compositions serve for a desquamation of the skin surface and as such they are again of symptomatic effect only as the disease will not be terminated.
In the popular therapy a wide scale of medicinal herbs is used against skin diseases. No medicinal herb has been knowa, however , for the effective treatment of psoriasis .
Accordingly, the present invention aims to provide a composition which not only serves for symptomatic treatment of psoriasis , but also suppresses the same finally or at least for a long period.
The invention is based on the recognition that some combinations of medicinal herbs when used externally on the skin, provide a method of treatment and therapeutical composition, respectively, which fulfil the requirements as aimed above.
Disclosure of Invention The present invention provides therapeutical compositions against psoriasis which comprises a combination of different medicinal herbs. Another object of the invention is the process for preparing the above therapeutical compositions . Another object of the present invention is the use of certain combinations of medical herbs in the treatment of psoriasis , rheumatic symptoms and asthmatic dyspnoea.
According to the present invention the therapeutical compositions comprise the extracts of the following drug plants: Allium sativum /garlic /, Urtica dioica /common nettle / , Chelidonium ma jus /milkweed/, Veronica officinalis /veronica/ , Calendula officinalis /calendula or marigold/ ,
Achillea herba /millefolium/ /yarrow/ , Fumaria officinalis /fumitory, earth -gall/ .
The therapeutical compositions according to the pre sent invention comprise suitably the extracts of at least three of the above medical herbs .
In the natural therapy the garlic is especially used against senescense symptoms, arteriosclerosis , hypertonia, diarrhoea , intestinal worms, etc. The juice thereof is said to be effective against warts as well. The plant comprises garlic oil, alliin and allicin as pharmacologically active ingredients . The latter may be regarded as antibiotic but possesse s insecticidal effect as well.
The main amount of the common nettle drug is used in the preparation of chlorophyll. The tea thereof is used against rheumatism, gout, diabetes , oedema, urticaria, catarrhal cystitis , hypertonia , gastroenteritis , exanthems , renal gravel , etc . Externally it has the use against haemorrhoid as sitting bath, against exanthems as lotion , against psilosis , seborrhea and oily hair as hair wash .
The milkweed belongs to the family of Papaveraceae . The drug thereof is used in the preparation of medicines against bilious and liver disorders , as well as gastroenteritis also in industrial scale . The fresh juice of the plant serves for treating warts and corns .
The tea of veronica is known as antitussive and against asthma and cardiac asthma.
The decoction of calendula may be used internally against gastric and intestinal ulcer and externally for packing of slowly healing wounds and ulcers . It is also known as colouring agent in foodstuffs, medicine a nd drinks.
The drugs of yarrow are appetizers and digestives. They can be used as anticσnvulsiva for promoting the bile and liver function, in the treatment of ureteral and respiratory disorders and as hypotensive agents , respectively. Externally, the concoction thereof is useful wash and lotion against gingival, ocular and general inflammations.
The tea of fumitory has appetizing, digestive, laxative and choleretic effect. It is used against icterus as well.
During our experiments it has been established that the above drugs, when used separately, did not provide sufficient curative effect against psoriasis . Surprisingly, it has been found that certain combinations of the same which comprise preferably at least two or more of the above medical herbs a high curative effect might be obtained. Therefore the compositions according to the present invention comprise suitably at least three of the extracts of the above drug plants. Of course , the therapeutical compositions may also contain more than three active ingredients, e. g. all the seven as well.
In the compositions according to the present invention the extracts of the above medicinal herbs are preferably those prepared with an oil. As oil, vegetable, animal and mineral oils can be used. During the extraction preferably paraffin oil or sunflower oil is used. The composition according to the present invention are prepared preferably in a form suitable for the treatment of skin. For these purposes the oily extract of the medicinal herbs itself or the mixture thereof with at least one additive generally used in the preparation of external topical compositions may be used. Especiall preferred additive is the paraffin oil which may be of medical grade /PH. HG . VII/ or cosmetic grade as well. The compositions according to the present invention may also contain further additives known per se , e. g. colouring agents, flavouring agents , etc. As flavouring and colouring agents not only the additives generally used by the pharmaceutical industry, but also additional medical herb extracts can be used. Such medical herbs are e . g. the followings: Calami rhizoma /sweet-sedge /, Quercus cortex /oak-bark/, Salix alba /cortex/ /willow cortex /, Taraxi radix /daudelion/ /cortex/, Alcanae radix /alkanna/.
The preparation of the therapeutical compositions is accomplished preferably by pouring the suitable extraction oil on the appropriately crushed, preferably ground dry medical herb , and keeping the mixture on elevated temperature for a longer period. Afterwards the supernatant is separated from the solid plant residue and the supernatant is used for the treatment as such or for mixing with additional additives to prepare therapeutical compositions . In case when besides the active ingredients medical herbs are also used as additives, it is preferred to introduce the latter in the extraction step. The period and temperature of the extraction procedure is not critical, any temperature which does not result in thermal degradation of the active substances in the drugs may be used while the extraction period should be long enough to provide a reasonable extraction grade at the temperature used. Preferably the extraction is carried out for 12 to 48 hours , at a temperature of 40 to 70 °C .
According to the preferred embodiment of the process the extraction is carried out for 24 hours at 60 °C . According to the most preferred embodiment of the present invention during the extraction carried out with the oil not the whole garlic but the solid material content having previously been extracted with an alcohol is used. By this previous extraction the appearance of the composition can substantially be improved. The alcoholic extraction of garlic can be carried out with any liquid alcohol, preferably methanol and ethanol. The use of 96 % ethanol is mo st preferred . The temperature and period of the alcoholic extraction is not critical, it can be carried out preferably below or on the boiling point of the alcohol used therein. The extraction is preferably carried out also at 60 °C for 24 hours under continuous stirring. After the extraction the alcohol is removed from the solid material, preferably by filtering, the solids are dried, preferably in vacuo at 50 to 60 ºC and then added to the dry material of the oil extraction.
During our experiments a large number of patients were treated with the compositions according to the present invention and in 90 % of the treatments after several weeks use the symptoms of psoriasis completely disappeared and did not re-appear. Of course, the treatment period strongly depends on the grade of disease and age and physical condition of the patient.
During our experiments it has also been surprisingly found that the medical herbs used in the above compositions and/or the compositions themselves are not only active against psoriasis but also against rheumatism and asthmatic dyspnoea. Accordingly, another object of the present invention is the use of the above medical herbs , the mixtures thereof and the compositions containing the same in tne treatment of rheumatism and asthmatic dyspnoea.
Best Mode of Carrying out the Invention
The present invention is further illustrated in the following example without limiting the scope of protection to the embodiment illustrated therein. Example
10 kg of garlic was crushed and ground and put into an appropriate container. 7,5 liter of 96 % ethanol was poured on and the mixture was kept for 24- hours at 60 °C while continuously stirring. The supernatant w as separated and the residue was dried in vacuo at 50 to 60 C until disappearing of the alcohol smell. The dry garlic material, pre-treated as above , was added to the following crushed and ground medical herb dry material: Urtica dioica /common nettle/ 300 g,
Chelidonium majus /milkweed/ 300 g,
Veronica officinalis /veronica/ 300 g, Calendula officinalis /calendula/ 300 g,
Achillea herba /yarrow/ 200 g,
Fumaria officinalis /fumitory/ 200 g,
Calami rhizoma /sweet- sedge / 200 g, Quercus cortex /oak -bark/ 100 g,
Salix alba /cortex/ /willow cortex/ 300 g,
Taraxi radix /daudelion/ / cortex/ 300 g,
Alcanae radix /alkanna/ 5 g.
The crushed dry material was mixed, 90 liter of paraffin oil was poured thereon and the mixture thus obtained was stirred for 24 hour at 60 °C . The dry material was separated by centrifuging and if the extra was turbid, filtered. To the clear oil composition thus obtained 10 liter of sunflower oil was added and filled into appropriate bottles or other containers. Thus, compositions against psoriasis , ready for use were obtained.
In the compositions according to the invention any of the seven major components may be present in 0 to 60 % of the total dry weight of active ingredients. The garlic may be present even in a higher concentration, i. e. up to 90 %.

Claims

Claims
1. Therapeutical composition against psoriasis, characterized by comprising the oil extract of at least three medical herbs selected from the group consisting of Allium sativum /garlic/, Urtica dioica /common nettle/, Chelidonium majus /milkweed/, Veronica officinalis /veronica/, Calendula officinalis /calendula or marigold/, Achillea herba /millefolium/ /yarrow/, Fumaria officinalis /fumitory, earth-gall/.
2. The composition according to claim 1, char acterized by further containing at least one carrier and /or additive useful for external therapeutical purposes.
3. The composition according to claim 2, characterized by containing as additive the oil extract of Calami rhizoma /seet-sedge/, Quercus cortex /oak-bark/, Salix alba /cortex/ /willow cortex/, Taraxi radix /daudelion/ /cortex/, Alcanae radix /alkanna/.
4. The composition of any cf the claims 1 to 3, charact erized by containing an extract made with paraffin oil.
5. The composition of any of the claims 1 to 4, characteriz ed by containing sunflower oil.
6. Process for preparing therapeutical compositions against psoriasis, characteri zed in that at least three of the medical herbs selected from the group cons isting of Allium sativum /garlic/, Urtica dioica /common nettle/, Chelidonium majus /milkweed/, Veronica officinalis /veronica/, Calendula officinalis /calendula or marigold/, Achillea herba /millefolium/ /yarrow/, Fumaria officinalis /fumitory, earth-gall/, as well as - if desired - the crushed dry material of one or more medical herbs selected from the group consisting of Calami rhizoma /sweet- sedge/, Quercus cortex /oak-bark/, Salix alba /cortex/ /willow cortex/, Taraxi radix /daudelion/ /cortex/, Alcanae radix /alkanna /is extracted with vegetable, animal or mineral oil and the oily supernatant is separated.
7. The process according tu claim 6, characterized by carrying out the extraction with paraffin oil.
8. The process according to claims 6 or 7, ch ar acte ri ze d in that the garlic is used during the extraction as a dry material obtained from a previous extraction by alcohol.
9. The process according to any of claims 6 to 8, charac te ri zed in that garlic is extracted with 96 % ethanol at elevated temperature, the supernatant is separated and the dried solid residue is combined with the other crushed medical herb dry material, the mixture is extracted with oil and the supernatant is separated from the solid material by centrifuging.
10. Use of at least three of the medical herbs selected from the group consisting of Allium sativum /garlic/, Urtica dioica /common nettle/, Chelidonium majus /milkweed/, V eronica officinalis /veronica/, Calendula officinalis /calendula or marigold/, A chillea herba /millefolium/ /yarrow/, Fumaria officinalis /fumitory, earth-gall/ for the treatment of psoriasis, rheumatism and asthmatic dyspnoea.
PCT/HU1987/000060 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis WO1989005651A1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
EP88900470A EP0364442B1 (en) 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis
US07/397,429 US5165932A (en) 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis
KR1019890701570A KR900700117A (en) 1987-12-23 1987-12-23 Remedies for Psoriasis
JP63500599A JPH0653672B2 (en) 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis
AU10539/88A AU610551B2 (en) 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis
DE8888900470T DE3784522T2 (en) 1987-12-23 1987-12-23 MEDICAL COMPOSITIONS AGAINST PSORIASIS.
AT88900470T ATE86114T1 (en) 1987-12-23 1987-12-23 MEDICAL COMPOSITIONS AGAINST PSORIASIS.
PCT/HU1987/000060 WO1989005651A1 (en) 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis
MC87HU8700060D MC2056A1 (en) 1987-12-23 1987-12-23 THERAPEUTIC COMPOSITION AGAINST PSORIASIS, METHOD FOR THE PREPARATION THEREOF AND USE OF MEDICINAL PLANTS THEREOF
IL88659A IL88659A (en) 1987-12-23 1988-12-12 Therapeutical compositions on medical herb basis for the treatment of psoriasis
BG86509A BG50491A3 (en) 1987-12-23 1988-12-20 Method for the production of a therapeutical formulation for the treatment of psoriasis
ZA889484A ZA889484B (en) 1987-12-23 1988-12-20 Therapeutical compositions against psoriasis
CS888632A CS277019B6 (en) 1987-12-23 1988-12-22 Remedy for psoriasis treatment and process for preparing thereof
DD88323714A DD277210A5 (en) 1987-12-23 1988-12-22 THERAPEUTIC COMPOSITIONS AGAINST PSORIASIS
PL88276650A PL276650A1 (en) 1987-12-23 1988-12-22 Method of obtaining a therapeutic composition against psoriasis
CN88108776A CN1025002C (en) 1987-12-23 1988-12-22 Therapeutical compositions against psoriasis
CA000586781A CA1319324C (en) 1987-12-23 1988-12-22 Therapeutical compositions against psoriasis
NO893330A NO178844C (en) 1987-12-23 1989-08-18 Process for the preparation of therapeutic preparations for psoriasis
FI893920A FI95200C (en) 1987-12-23 1989-08-21 Process for the preparation of a therapeutic composition for psoriasis
DK415889A DK415889D0 (en) 1987-12-23 1989-08-23 THERAPEUTIC PREPARATIONS AGAINST PSORIASIS
HR930299A HRP930299A2 (en) 1987-12-23 1993-03-11 Therapeutical compositions against psoriasis

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PCT/HU1987/000060 WO1989005651A1 (en) 1987-12-23 1987-12-23 Therapeutical compositions against psoriasis

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JP (1) JPH0653672B2 (en)
KR (1) KR900700117A (en)
CN (1) CN1025002C (en)
AT (1) ATE86114T1 (en)
AU (1) AU610551B2 (en)
BG (1) BG50491A3 (en)
CA (1) CA1319324C (en)
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DE (1) DE3784522T2 (en)
DK (1) DK415889D0 (en)
FI (1) FI95200C (en)
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WO1991015218A1 (en) * 1990-04-03 1991-10-17 Angeli Tamas Sr Therapeutical composition against psoriasis on medicinal herb basis
GR1000204B (en) * 1988-12-08 1992-03-20 Psoricur Ltd Therapeutical compositions against psoriasis
ES2051233A1 (en) * 1992-11-16 1994-06-01 Inkeysa Sa Therapeutic compositions for topical use for the effective treatment of psoriasis
ES2065292A1 (en) * 1993-07-30 1995-02-01 Inkeysa Sa Compositions comprising Plantago Mayor, Rosa Canina and Citrus Aurantium for treating psoriasis.
WO1998032761A1 (en) * 1997-01-24 1998-07-30 University Of Strathclyde Use of stereoisomers of calendula glycosides for the treatment of psoriasis
ITMI20131051A1 (en) * 2013-06-25 2014-12-26 Maria Oliva Salviati USE OF A COMPOSITION THAT INCLUDES NETTLE
EP2723319B1 (en) 2011-06-24 2017-03-29 Merz Pharma GmbH & Co. KGaA Composition comprising an onion extract and liposomes

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US5444092A (en) * 1994-07-20 1995-08-22 Collins; Jerry Method and composition for treating psoriasis
GB9515214D0 (en) 1995-07-25 1995-09-20 Univ Strathclyde Plant extracts
US5776920A (en) * 1995-08-02 1998-07-07 Quarles; Ruth Method for treatment of psoriasis
US5776477A (en) * 1996-07-08 1998-07-07 Ryder; Kathleen A. Organic insect repellent
DE19628284C1 (en) * 1996-07-12 1997-12-18 Georgios Dr Pandalis Use of wild garlic for the treatment or prophylaxis of hyperkeratosis
US8105690B2 (en) 1998-03-03 2012-01-31 Ppg Industries Ohio, Inc Fiber product coated with particles to adjust the friction of the coating and the interfilament bonding
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US6379715B2 (en) 2000-01-10 2002-04-30 Apolonia Jaros Method for treatment of psoriasis
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HU227318B1 (en) * 2000-03-08 2011-03-28 Tibor Bodnar Cosmetical and dematological composition for treating, grooming of psoric skin and scalp
US6406707B1 (en) 2000-06-13 2002-06-18 Apolonia Jaros Method for treatment of psoriasis
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US20060177527A1 (en) * 2005-02-04 2006-08-10 Shoshana Moses Methods and compositions for treating psoriasis
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US20090181113A1 (en) 2005-11-28 2009-07-16 Apptec, Inc. Compositions for the reversal of stratum granulosum in keratinization disorders
US7666450B2 (en) * 2007-12-04 2010-02-23 Apptec, Inc. Herbal compositions for the regression of chronic inflammatory skin disorders
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WO2019160209A1 (en) * 2018-02-13 2019-08-22 한국 한의학 연구원 Composition for preventing, ameliorating, or treating allergic diseases, containing veronica persica extract as active ingredient
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DE3300491A1 (en) * 1982-03-31 1984-07-12 Maria 7530 Pforzheim Marks Composition for promoting hair growth and for reducing dandruff
EP0133151A2 (en) * 1983-07-27 1985-02-13 Daniel Berman Skin ointment

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1000204B (en) * 1988-12-08 1992-03-20 Psoricur Ltd Therapeutical compositions against psoriasis
WO1991015218A1 (en) * 1990-04-03 1991-10-17 Angeli Tamas Sr Therapeutical composition against psoriasis on medicinal herb basis
ES2051233A1 (en) * 1992-11-16 1994-06-01 Inkeysa Sa Therapeutic compositions for topical use for the effective treatment of psoriasis
ES2065292A1 (en) * 1993-07-30 1995-02-01 Inkeysa Sa Compositions comprising Plantago Mayor, Rosa Canina and Citrus Aurantium for treating psoriasis.
WO1998032761A1 (en) * 1997-01-24 1998-07-30 University Of Strathclyde Use of stereoisomers of calendula glycosides for the treatment of psoriasis
US6313099B1 (en) 1997-01-24 2001-11-06 University Of Strathclyde Use of stereoisomers of calendula gylcosides for the treatment of psoriasis
EP2723319B1 (en) 2011-06-24 2017-03-29 Merz Pharma GmbH & Co. KGaA Composition comprising an onion extract and liposomes
ITMI20131051A1 (en) * 2013-06-25 2014-12-26 Maria Oliva Salviati USE OF A COMPOSITION THAT INCLUDES NETTLE

Also Published As

Publication number Publication date
DE3784522D1 (en) 1993-04-08
DD277210A5 (en) 1990-03-28
FI95200B (en) 1995-09-29
FI893920A0 (en) 1989-08-21
ZA889484B (en) 1989-09-27
IL88659A (en) 1993-04-04
CS863288A3 (en) 1992-05-13
CS277019B6 (en) 1992-11-18
CA1319324C (en) 1993-06-22
AU1053988A (en) 1989-07-19
EP0364442B1 (en) 1993-03-03
AU610551B2 (en) 1991-05-23
US5165932A (en) 1992-11-24
ATE86114T1 (en) 1993-03-15
PL276650A1 (en) 1989-08-21
NO893330D0 (en) 1989-08-18
DK415889A (en) 1989-08-23
FI95200C (en) 1996-01-10
DK415889D0 (en) 1989-08-23
EP0364442A1 (en) 1990-04-25
MC2056A1 (en) 1990-09-04
DE3784522T2 (en) 1993-06-17
KR900700117A (en) 1990-08-11
CN1035052A (en) 1989-08-30
JPH02502631A (en) 1990-08-23
JPH0653672B2 (en) 1994-07-20
NO893330L (en) 1989-08-18
IL88659A0 (en) 1989-07-31
NO178844C (en) 1996-06-19
NO178844B (en) 1996-03-11
FI893920A (en) 1989-08-21
BG50491A3 (en) 1992-08-14
CN1025002C (en) 1994-06-15

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