WO1990008260A1 - Magnetically actuated positive displacement pump - Google Patents
Magnetically actuated positive displacement pump Download PDFInfo
- Publication number
- WO1990008260A1 WO1990008260A1 PCT/US1990/000264 US9000264W WO9008260A1 WO 1990008260 A1 WO1990008260 A1 WO 1990008260A1 US 9000264 W US9000264 W US 9000264W WO 9008260 A1 WO9008260 A1 WO 9008260A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diaphragm
- core
- magnet
- electromagnet
- pump
- Prior art date
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
- A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/424—Details relating to driving for positive displacement blood pumps
- A61M60/457—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being magnetic
- A61M60/462—Electromagnetic force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/562—Electronic control means, e.g. for feedback regulation for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/835—Constructional details other than related to driving of positive displacement blood pumps
- A61M60/837—Aspects of flexible displacement members, e.g. shapes or materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/871—Energy supply devices; Converters therefor
- A61M60/878—Electrical connections within the patient's body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
- B29C33/40—Plastics, e.g. foam or rubber
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/06—Electromagnets; Actuators including electromagnets
- H01F7/08—Electromagnets; Actuators including electromagnets with armatures
- H01F7/16—Rectilinearly-movable armatures
- H01F7/1607—Armatures entering the winding
- H01F7/1615—Armatures or stationary parts of magnetic circuit having permanent magnet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/89—Valves
- A61M60/894—Passive valves, i.e. valves actuated by the blood
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/06—Electromagnets; Actuators including electromagnets
- H01F7/08—Electromagnets; Actuators including electromagnets with armatures
- H01F7/121—Guiding or setting position of armatures, e.g. retaining armatures in their end position
- H01F7/122—Guiding or setting position of armatures, e.g. retaining armatures in their end position by permanent magnets
Definitions
- This invention relates to a magnetically actuated positive displacement pump for the controlled pulsatile pumping of liquids/ and an electromagnetic actuator therefor.
- the flow rate of liquid, as well as the shape of the pressure wave developed, is variable.
- the pump is efficient due to an efficient electromagnetic actuator developed especially for use
- the obj ect of a prosthetic heart device is to assist or replace the left ventri cl e of a human heart.
- Such devices are known by the acronym LV D for Left Ventricle Assist Device.
- Pneumatic devices use external compressors to produce high-pressure air which powers the device.
- the device is generally intracorporal , and the pneumatic lines pass through the body wall to connect the prosthetic device with the high-pressure air source.
- the problems associated with such a pneumatic LVAD include the fact that as the pneumatic lines pass through the body wall, there is a high chance of sepsis or infection since, the lines pulse with each
- Hydraulic LVAD's have a separate set of problems.
- Such LVAD's generally consist of a motor and pump blade with the pump blade in direct contact with the blood being pumped. Blood is in contact with many surfaces in the pump. Consequently, the number of blood cells damaged during pumping is high, as is the likelihood of platelet aggregation or clotting. Further, the motor's inertia may cause small twisting movements of the LVAD with each pulse, leading to additional complications or patient discomfort.
- electromagnetic LVAD's have been made in many different configurations.
- those configurati ns have generally possessed high power requirements.
- this is due to the fact that the pumping mechanism (diaphragm, etc.) lacks means by which to return to its starting position without the use of external power. Therefore, power must be supplied to move the mechanism in both directions. Power is required to pump the blood and to fill the pump chamber with blood from an auricle.
- These high power requirements also stem from inefficient conversion of electrical energy to magnetomotive force.
- This pump includes a means for filling the pump chamber with liquid (e.g. blood) without the application of electrical energy.
- liquid e.g. blood
- electrical energy is required for only one-half of the pump's cycle. Further, it utilizes a minimum of moving parts to wear out, break down, or damage blood cells.
- the pump has a pump chamber with a movable diaphragm forming one wall.
- a magnet is coaxially
- the pump chamber also has two substantially one-way valves, one for the inflow of fluid and one for the outflow.
- the pump has an electromagnetic actuator.
- the actuator produces an electromagnetic pulse which repulses a permanent magnet attached to the diaphragm.
- the permanent magnet and diaphragm move away from the actuator causing a reduction in volume of the pumping chamber and expulsion of fluid through the outlet valve.
- electricity to the actuator is switched off, the diaphragm magnet is attracted to the actuator's ferromagnetic core. This causes the diaphragm to return to its initial position, thus increasing the volume of the pumping chamber causing it to fill with fluid.
- the efficiency of this pumping action is optimized by specific configurations and choice of materials for various pump elements.
- Figure 1 is a plan view of the pump of the present invention.
- Figure 2 is a cross sectional view of the pump of the present invention.
- Figure 3 is a plan view of the inside of the pump chamber wall.
- Figure 4 is a cross sectional view of the diaphragm assembly of the pump of the present invention.
- LVAD 10 including actuator 50 which provides the electromagnetic force to power LVAD 10.
- Actuator 50 derives power in turn from an external power source via wire leads 59.
- wire leads 59 may be connected to an extracorporal power source by means of a "skin plug" or some similar apparatus to convey electrical power through the body wall.
- the particular actuator configuration used in the pump of the present invention solves several problems. First, it is desirable to direct the maximum amount of magnetic flux to front core face 61 and into air gap 62 between front core face 61 and diaphragm magnet 43. Second, it is desirable to provide means whereby diaphragm magnet 43 and diaphragm 41 return to their starting positions without the application of external power. The actuator of the present invention solves both of these problems, as discussed below.
- electromagnetic actuator 50 includes a ferromagnetic core 60 of three sections: rear core section 55; core cup 56; and core cup magnet 58.
- Core section 60 is surrounded by bobbin 53 around which are windings 52a, b, and c, collectively referred to as coil 52.
- the wire used for windings 52a,b and c is preferably rectangular in cross section. Such rectangular wire allows closer packing than wire having a circular cross section. More specifically, rectangular wire allows approximately a 30% decrease in actuator size, because upwards of 95% of the coil volume is occupied by rectangular wire whereas only about a 65% volume efficiency of winding density is achievable with circular wire.
- uniformity of winding allows close calculation of the magnetic field produced by the coil; therefore the amount of energy required to achieve the desired pumping effect is more easily and closely calculated.
- ease of winding is increased with rectangular wire. Such rectangular wire is available upon special order from MWS Wire Industries of West Lake Village, CA.
- the outer surface of bobbin 53 preferably comprises a series of cylindrical sections each of decreasing radius as shown in Fig. 2. This allows for ordered windings of rectangular wire around a tapered core. This is all contained in flux shell 51 and held in place by case screws 54. -8-
- Core 60 is a rev erse taper hol l ow cor e.
- the front face 61 of core 60 has a greater circumference than the rear face of core 60 (the front face being that face closer to diaphragm assembly 40) .
- This configuration is referred to as a reverse taper core.
- the reverse taper core increases magnetic fl ux densi ty at the front face due to the fact that in such a rev erse taper core, the magnetic neutral plane is moved toward that front face.
- the definition of the magnetic neutral plane is that it is l ocated where all magneti c fl ux paths wil l intersect it at right angles .
- the magnetic neutral plane is coincident with the geometric neutral plane (midpoint between the core ends) .
- the reverse taper core design of this invention allows the core to intercept more of the magneti c fl ux in the coil region than could be intercepted by a conventional cylindrical core. This all ows for lower leakage of the magnetic fl ux and consequently lower losses in power.
- more of the electri cal energy input to the coil is converted to magnetic flux at the front core face than would otherwise be possible with a conventional cylindrical core.
- Core cup 56 has a hollow central portion in which cup magnet 58 resides. This causes the lines of flux to concentrate in the perimeter of front core face 61. This directs a greater proportion of flux to air gap 62 between core 60 and diaphragm magnet 43.
- Core cup 56 and rear core section 55 are hollow throughout their entire length. The hollow area is partially filled with non-magnetic core screw 57. This core screw also holds core cup 56 in place.
- Rear core section 55 and core cup 56 are made from a ferromagnetic material such as Vanadium Permendur. Two sections are necessary only because of the problems involved in machining a single piece of this particular configuration.
- Core cup magnet 58 and diaphragm magnet 43 are preferably made of some strong, persistant magnetic material such as neodymium boron iron. This particular material is preferred because it has a high megagauss-oersted (MGO) value. Generally, the MGO value of neodymium boron iron is around 35. Because of this high MGO value, a permanent magnet made from this material will produce a very persistent magnetic field which will not deteriorate significantly with time and high use.
- MGO megagauss-oersted
- Core cup magnet 58 is held in place by its own magnetic attraction to core cup 56 and rear core -10-
- Core cup magnet 58 is centered coaxially in core cup 56 by a small ridge in core cup 56.
- Core cup magnet 58 is ori ented so as to be in a repul si on mode with permanent diaphragm magnet 43.
- Core 60 is surrounded by bobbin 53.
- This bobbin is stepped on its outer surface in order to al l ow easier and more regular packing of rectangular windings 52a, b, and c than would be possibl e with a bobbin having smoothly tapered sides.
- the enhanced magnetic effect of this stepped bobbin and windings is significant in that it allows about a 30% decrease in actuator size. Additionally, ease of winding is greatly increased.
- This entire arrangement is secured i n fl ux shell 51 by case screws 54.
- Fl ux shel l 51 is made of any standard ferromagnetic material.
- Bobbin 53 is made of non-magnetic material such as plastic or ceramic.
- Actuator 50 is attached to interface mount
- diaphragm assembly 40 consists of diaphragm 41, diaphragm magnet 43 and backing plate 42.
- Backing plate 42 has an annular configuration.
- Diaphragm 41 It is held in place in diaphragm 41 by means of a small annular recess into which backing plate 42 fits snugly.
- Diaphragm magnet 43 is held to backing plate 42 by means of the magnetic attraction between them.
- Backing plate 42 is made of some standard ferromagnetic material such as Vanadium Permendur. Backing plate 42 helps enhance the flux density through the front and rear planes of pusher plate magnet 43. Preferably, the ratio of the radii of the backing plate to the diaphragm magnet is 1.2:1.
- Diaphragm 41 has a double roll as can be seen from Figure 4. From the outside of the diaphragm moving inward, the diaphragm first turns upward, then turns downward below its original level. This double roll allows for greater flexibility of movement of diaphragm 41.
- diaphragm assembly 40 forms one wall of pump chamber 20.
- the remainder of pump chamber 20 is formed by pump chamber wall 30.
- Pump chamber wall 30 is also shown in Figure 3.
- Pump chamber wall 30 is asymmetrical. and has an inlet port 31 and an outlet port 32. The asymmetric shape of pump chamber wall 30 enables increased efficiency for pumping by providing positive vector control for flow movement toward the outlet port
- Asymmetric pump chamber wall 30 therefore lowers the power requirements of LVAD 10.
- fl uid Upon application of pressure by diaphragm 40 , fl uid is pref erentially directed toward outl et port 32 by virtue of chamber asymmetry. Any fl uid directed back toward inl et port 31 is prevented from exi ting the chamber by a conventional one-way valve (not shown) installed in inlet port 31.
- a similar valve allowing only the outfl ow of fluid is install ed in outl et port 32.
- Suitabl e valve assemblies approved for use in humans are availabl e from a number of manufacturers, incl uding Medtronic, Inc. of Minneapolis, Minnesota or
- the inlet and outlet valves are preferably of 27 and 25 millimeter lumen respectively.
- Pump chamber wall 30 and diaphragm 41 are both made of a suitably inert (with respect to the fl uid being pumped) , somewhat fl exibl e material.
- the pref erred material for LVAD 10 (and for other vascular system prosthetic devices as wel l, such as veins and arteries) is the copolymer of polytetramethylene oxide-di-p-aminobenzoate (hereinafter "aminobenzoate”) and diphenylmethane diisocyanate (hereinaf ter “diisocyanate”) availabl e for example from Mobay -13-
- the polymeric resin includes preferably 7 parts aminobenzoate and 6 parts diisocyanate, with a resulting shore A hardness value of between 85 and 90 once cured.
- the polymeric resin of diaphragm 41 preferably includes 8.5 parts aminobenzoate and 5.5 parts diisocyanate, with a resulting shore A hardness value of between 55 and 60 once cured.
- diaphragm 41 is more flexible than pumping chamber wall 30, since pumping chamber wall 30 is relatively stationary, while diaphragm 40 oscillates.
- Pump chamber wall 30 and diaphragm 41 are preferably pour cast in an RTV (Room Temperature Vulcanizing) silicone mold, the mold itself having been formed using an electropolished acrylic, e.g. polymethyl methyl aery late (Lucite) master.
- RTV Room Temperature Vulcanizing
- This, (with the preferred casting composition referred to above) provides a smooth surface which minimizes platelet aggregation.
- Traditional molding methods such as injection molding or vacuum forming give rise to difficulties not experienced when an RTV silicone -14-
- Inj ection molding l eaves inherent stress points and weak spots in the pumping chamber. Vacuum forming results in very small irregul arities which can lead to platelet aggregation and bl ood cl ot formation.
- the particular copolymer heretofore described in conj unction with RTV sili cone mold pour casting may also be used to produce artificial veins and arteries to be used ei ther al one or in conj unction wi th the LVAD of the present invention.
- One aspect of this invention is the making of vascular system prosthetic devices, such as artificial heart chambers, veins, arteries, etc. by the method j ust described.
- the resultant products of this method are also another aspect of this invention.
- the method comprises, in general, making a prosthetic -15-
- the device for the vascular system by forming a positive acrylic master of the device and surface polishing the master.
- An RTV silicone negative mold is formed from the master, and the device is pour formed using the mold, by coating the mold with a mixture of aminobenzoate and diisocyanate.
- the resin is then cured such as by heat curing and removed from the mold.
- the master is made from electropolished polymethyl methyl aery late (Lucite).
- the preferred polymeric resin is a mixture of polytetramethylene oxide-di-p-aminobenzoate and diphenylmethane diisocyanate (as previously indicated) .
- diaphragm 41 In operation, diaphragm 41 is at rest in the position shown in Figure 2.
- Pumping chamber 20 is filled with blood. Electrical energy is applied via wire leads 59 to various windings 52a, 52b, and 52c. Each winding is individually actuable. The magnetic force thus generated is channeled through core 60 to repel diaphragm magnet 43. This repulsion causes a movement of diaphragm 41 to the position shown in shadow in Figure 2. This causes a reduction in volume of pumping chamber 20 and expels blood out through outlet port 32.
- the pulsatile pumping action of LVAD 10 may be made to simulate the pumping action of an actual heart ventricle, producing a pressure wave for an output
- SUBSTITUTE SHEET which is v ery similar to that produced by a natural heart ventricl e.
- Permanent diaphragm magnet 43 is attracted to the non-magnetized ferromagnetic material in core 60 as well as the f erromagnetic material of flux shel l 51. Howev er , cor e cup magnet 58 is in a repul sion mode with diaphragm magnet 43. The attraction between diaphragm magnet 43 and the ferromagnetic material in actuator 50 is stronger than the repulsion created by core cup magnet 58. Diaphragm 41 begins to move toward actuator 50, increasing the vol ume of pump chamber 20 and drawing bl ood in through inl et port 31. The mov ement of diaphragm 41 toward actuator 50 is slowed by the increase in repul sion between core cup magnet 58 and diaphragm magnet 43.
- This bipolar field effect slows the movement of diaphragm 41 toward actuator 50. If this mov ement were too rapid, an undue strain would be placed upon the auricl e from which blood is drawn through inl et port 31.
- This bipol ar field effect also prevents a large magnetic attraction from building up between diaphragm magnet 43 and the f erromagnetic portions of actuator 50. Such a high magnetic attraction would be difficult to overcome for each ⁇ ucceeding pump cycle, and the pump operation would require large amounts of power. Instead, the power needed to repulse diaphragm magnet 43 and pump blood out of outlet port 32 is kept to a minimum, as are the power requirements of the overall operation of the
- diaphragm 41 At rest, diaphragm 41 is fully extended toward actuator 50.
- An air gap 62 occurs between pusher plate magnet 43 and core cup magnet 58. The width of this air gap may be adjusted since, as previously explained, the actuator is held by threads into interface mount 45.
- interface mount As shown in Figs. 1 and 2, interface mount
- interface mount ports 48 allow air to flow freely in and out from between pusher plate magnet 43 and core cup magnet 58. When used as an LVAD, this air is supplied from an area surrounding the actuator and enclosed by an outer bag or jacket.
Abstract
A positive displacement pump is provided which is especially suited to be used as a left ventricle assist device (LVAD) (10). The pump is electromagnetically actuated. An electromagnet (52) produces a pulse which repels a magnet (43) mounted in a diaphragm (40) which forms one wall of a pumping chamber (20). The pumping chamber (20) thereby constricts and fluid is expelled. The electromagnet (50) has a reverse taper core and core cup magnet (58) which produce a bipolar field effect upon a diaphragm magnet (43) to cause the return of the diaphragm (40) to its starting position, without the application of external power.
Description
MAGNETICALLY ACTUATED POSITIVE DISPLACEMENT PUMP
Field Δ£ __h& Invention
This invention relates to a magnetically actuated positive displacement pump for the controlled pulsatile pumping of liquids/ and an electromagnetic actuator therefor. The flow rate of liquid, as well as the shape of the pressure wave developed, is variable.
The pump is efficient due to an efficient electromagnetic actuator developed especially for use
S B TITUT
in this pump. By shaping the electrical pulse to the electromagnetic actuator one can vary the shape of the pressure wave produced by the pump, as well as the flow rate of fluid produced by the pump. The pulsatile action, shaped pressure wave, relatively small size and high efficiency of the pump make it especially useful as a prosthetic heart, to replace or assist a malfunctioning natural heart, or portion thereof.
Background of the InvfinH on
General ly, the obj ect of a prosthetic heart device is to assist or replace the left ventri cl e of a human heart. The l eft ventricle suff ers the greatest damage in most heart cases and a repl acement or ai d therefor is desirable. Such devices are known by the acronym LV D for Left Ventricle Assist Device.
The concept of providing a prosthetic heart device is not new. Many such devices exist, howev er, each has probl ems which remain, to date, unsolved. Most LVAD's fall into three general categories : pneumati c, hydraulic and el ectromagnetic.
Pneumatic devices use external compressors to produce high-pressure air which powers the device. The device is generally intracorporal , and the pneumatic lines pass through the body wall to connect
the prosthetic device with the high-pressure air source. The problems associated with such a pneumatic LVAD include the fact that as the pneumatic lines pass through the body wall, there is a high chance of sepsis or infection since, the lines pulse with each
"beat" of the LVAD.
Additionally, very high pressure air is required to produce a satisfactory pulse rate and pressure in pneumatic LVADs, causing additional complications such as a high chance of valve failure. Pneumatic systems inherently include time lag as the pressure front travels through the pneumatic line. Finally, the quality of life of a patient dependent upon a pneumatic LVAD is poor because the patient is confined to a bed near the high-pressure air source.
Hydraulic LVAD's have a separate set of problems. Such LVAD's generally consist of a motor and pump blade with the pump blade in direct contact with the blood being pumped. Blood is in contact with many surfaces in the pump. Consequently, the number of blood cells damaged during pumping is high, as is the likelihood of platelet aggregation or clotting. Further, the motor's inertia may cause small twisting movements of the LVAD with each pulse, leading to additional complications or patient discomfort.
Finally, electromagnetic LVAD's have been made in many different configurations. Heretofore, those configurati ns have generally possessed high power requirements. In some instances, this is due to the fact that the pumping mechanism (diaphragm, etc.) lacks means by which to return to its starting position without the use of external power. Therefore, power must be supplied to move the mechanism in both directions. Power is required to pump the blood and to fill the pump chamber with blood from an auricle. These high power requirements also stem from inefficient conversion of electrical energy to magnetomotive force.
Summary _&_£ __s. Invention
In the electromagnetic pump of the present invention, problems are overcome by a pump design which is inherently more efficient in conversion of electrical energy to magnetomotive force. This pump includes a means for filling the pump chamber with liquid (e.g. blood) without the application of electrical energy. Thus, electrical energy is required for only one-half of the pump's cycle. Further, it utilizes a minimum of moving parts to wear out, break down, or damage blood cells.
The pump has a pump chamber with a movable diaphragm forming one wall. A magnet is coaxially
SUBSTITUTE SH£ T
aligned with and attached to the diaphragm. The pump chamber also has two substantially one-way valves, one for the inflow of fluid and one for the outflow. The pump has an electromagnetic actuator. The actuator produces an electromagnetic pulse which repulses a permanent magnet attached to the diaphragm. The permanent magnet and diaphragm move away from the actuator causing a reduction in volume of the pumping chamber and expulsion of fluid through the outlet valve. When electricity to the actuator is switched off, the diaphragm magnet is attracted to the actuator's ferromagnetic core. This causes the diaphragm to return to its initial position, thus increasing the volume of the pumping chamber causing it to fill with fluid.
Preferably, the efficiency of this pumping action is optimized by specific configurations and choice of materials for various pump elements.
__∑___£ Description £_£ ϊ_h__ Drawings
Figure 1 is a plan view of the pump of the present invention.
Figure 2 is a cross sectional view of the pump of the present invention.
-6-
Figure 3 is a plan view of the inside of the pump chamber wall.
Figure 4 is a cross sectional view of the diaphragm assembly of the pump of the present invention.
Detailed Description __£. ____& Preferred EmhnrHippηf
Referring now to Figure 2, there is shown an
LVAD 10, including actuator 50 which provides the electromagnetic force to power LVAD 10. Actuator 50 derives power in turn from an external power source via wire leads 59. When implanted in a human body, wire leads 59 may be connected to an extracorporal power source by means of a "skin plug" or some similar apparatus to convey electrical power through the body wall. The particular actuator configuration used in the pump of the present invention solves several problems. First, it is desirable to direct the maximum amount of magnetic flux to front core face 61 and into air gap 62 between front core face 61 and diaphragm magnet 43. Second, it is desirable to provide means whereby diaphragm magnet 43 and diaphragm 41 return to their starting positions without the application of external power. The actuator of the present invention solves both of these problems, as discussed below.
The specific configuration of electromagnetic actuator 50 is important. It includes a ferromagnetic core 60 of three sections: rear core section 55; core cup 56; and core cup magnet 58. Core section 60 is surrounded by bobbin 53 around which are windings 52a, b, and c, collectively referred to as coil 52. The wire used for windings 52a,b and c is preferably rectangular in cross section. Such rectangular wire allows closer packing than wire having a circular cross section. More specifically, rectangular wire allows approximately a 30% decrease in actuator size, because upwards of 95% of the coil volume is occupied by rectangular wire whereas only about a 65% volume efficiency of winding density is achievable with circular wire. Further, uniformity of winding allows close calculation of the magnetic field produced by the coil; therefore the amount of energy required to achieve the desired pumping effect is more easily and closely calculated. Finally, ease of winding is increased with rectangular wire. Such rectangular wire is available upon special order from MWS Wire Industries of West Lake Village, CA.
The outer surface of bobbin 53 preferably comprises a series of cylindrical sections each of decreasing radius as shown in Fig. 2. This allows for ordered windings of rectangular wire around a tapered core. This is all contained in flux shell 51 and held in place by case screws 54.
-8-
Core 60 is a rev erse taper hol l ow cor e. The front face 61 of core 60 has a greater circumference than the rear face of core 60 (the front face being that face closer to diaphragm assembly 40) . This configuration is referred to as a reverse taper core.
The reverse taper core increases magnetic fl ux densi ty at the front face due to the fact that in such a rev erse taper core, the magnetic neutral plane is moved toward that front face. The definition of the magnetic neutral plane is that it is l ocated where all magneti c fl ux paths wil l intersect it at right angles .
In a conventional (cylindrical) core, the magnetic neutral plane is coincident with the geometric neutral plane (midpoint between the core ends) . By moving this magnetic neutral plane toward front core face 61, the reverse taper core design of this invention allows the core to intercept more of the magneti c fl ux in the coil region than could be intercepted by a conventional cylindrical core. This all ows for lower leakage of the magnetic fl ux and consequently lower losses in power. Thus, more of the electri cal energy input to the coil is converted to magnetic flux at the front core face than would otherwise be possible with a conventional cylindrical core.
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Core cup 56 has a hollow central portion in which cup magnet 58 resides. This causes the lines of flux to concentrate in the perimeter of front core face 61. This directs a greater proportion of flux to air gap 62 between core 60 and diaphragm magnet 43. Core cup 56 and rear core section 55 are hollow throughout their entire length. The hollow area is partially filled with non-magnetic core screw 57. This core screw also holds core cup 56 in place. Rear core section 55 and core cup 56 are made from a ferromagnetic material such as Vanadium Permendur. Two sections are necessary only because of the problems involved in machining a single piece of this particular configuration.
Core cup magnet 58 and diaphragm magnet 43 are preferably made of some strong, persistant magnetic material such as neodymium boron iron. This particular material is preferred because it has a high megagauss-oersted (MGO) value. Generally, the MGO value of neodymium boron iron is around 35. Because of this high MGO value, a permanent magnet made from this material will produce a very persistent magnetic field which will not deteriorate significantly with time and high use.
Core cup magnet 58 is held in place by its own magnetic attraction to core cup 56 and rear core
-10-
section 55. Core cup magnet 58 is centered coaxially in core cup 56 by a small ridge in core cup 56. Core cup magnet 58 is ori ented so as to be in a repul si on mode with permanent diaphragm magnet 43.
Core 60 is surrounded by bobbin 53. This bobbin is stepped on its outer surface in order to al l ow easier and more regular packing of rectangular windings 52a, b, and c than would be possibl e with a bobbin having smoothly tapered sides. The enhanced magnetic effect of this stepped bobbin and windings is significant in that it allows about a 30% decrease in actuator size. Additionally, ease of winding is greatly increased. This entire arrangement is secured i n fl ux shell 51 by case screws 54. Fl ux shel l 51 is made of any standard ferromagnetic material. Bobbin 53 is made of non-magnetic material such as plastic or ceramic.
Actuator 50 is attached to interface mount
45 by means of threads in the interface mount and on actuator fl ux shell 51. Actuator 50 is held in place in interface mount 45 by set screws (not shown) . Interf ce mount 45 is held to diaphragm 40 and pump chamber wal l 30 by means of upper ring cl amp 46 and lower ri ng clamp 47 . Upper ri ng cl amp 46 and l ower ring cl amp 47 secure to one another by means of threads .
As shown in Figure 4, diaphragm assembly 40 consists of diaphragm 41, diaphragm magnet 43 and backing plate 42. Backing plate 42 has an annular configuration. It is held in place in diaphragm 41 by means of a small annular recess into which backing plate 42 fits snugly. Diaphragm magnet 43 is held to backing plate 42 by means of the magnetic attraction between them. Backing plate 42 is made of some standard ferromagnetic material such as Vanadium Permendur. Backing plate 42 helps enhance the flux density through the front and rear planes of pusher plate magnet 43. Preferably, the ratio of the radii of the backing plate to the diaphragm magnet is 1.2:1. Diaphragm 41 has a double roll as can be seen from Figure 4. From the outside of the diaphragm moving inward, the diaphragm first turns upward, then turns downward below its original level. This double roll allows for greater flexibility of movement of diaphragm 41.
As may be seen in Figure 2, diaphragm assembly 40 forms one wall of pump chamber 20. The remainder of pump chamber 20 is formed by pump chamber wall 30. Pump chamber wall 30 is also shown in Figure 3. Pump chamber wall 30 is asymmetrical. and has an inlet port 31 and an outlet port 32. The asymmetric shape of pump chamber wall 30 enables increased efficiency for pumping by providing positive vector control for flow movement toward the outlet port
SUBSTITUTE SHEET
region of the pump. Asymmetric pump chamber wall 30 therefore lowers the power requirements of LVAD 10.
Fl uid fl ows in through inl et port 31 as diaphragm 41 moves toward actuator 50. Upon application of pressure by diaphragm 40 , fl uid is pref erentially directed toward outl et port 32 by virtue of chamber asymmetry. Any fl uid directed back toward inl et port 31 is prevented from exi ting the chamber by a conventional one-way valve (not shown) installed in inlet port 31. A similar valve allowing only the outfl ow of fluid is install ed in outl et port 32. Suitabl e valve assemblies approved for use in humans are availabl e from a number of manufacturers, incl uding Medtronic, Inc. of Minneapolis, Minnesota or
St. Jude, al so of Minneapolis, Minnesota. The inlet and outlet valves are preferably of 27 and 25 millimeter lumen respectively.
Pump chamber wall 30 and diaphragm 41 are both made of a suitably inert (with respect to the fl uid being pumped) , somewhat fl exibl e material. Because of the specific requirements of an LVAD, the pref erred material for LVAD 10 (and for other vascular system prosthetic devices as wel l, such as veins and arteries) is the copolymer of polytetramethylene oxide-di-p-aminobenzoate (hereinafter "aminobenzoate") and diphenylmethane diisocyanate (hereinaf ter "diisocyanate") availabl e for example from Mobay
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Chemicals of Delaware. The former is available from several chemical producers including ICI Corp. of New Jersey, Mobay Chemicals of Delaware or Polaroid Corporation of Assonet, Massachusetts (under the tradename Polamine 1000). By varying the proportions of aminobenzoate and diisocyanate, one can controllably moderate the flexibility of the polymer. For example, in pump chamber wall 30, the polymeric resin includes preferably 7 parts aminobenzoate and 6 parts diisocyanate, with a resulting shore A hardness value of between 85 and 90 once cured. The polymeric resin of diaphragm 41 preferably includes 8.5 parts aminobenzoate and 5.5 parts diisocyanate, with a resulting shore A hardness value of between 55 and 60 once cured. Preferably, diaphragm 41 is more flexible than pumping chamber wall 30, since pumping chamber wall 30 is relatively stationary, while diaphragm 40 oscillates.
Pump chamber wall 30 and diaphragm 41 are preferably pour cast in an RTV (Room Temperature Vulcanizing) silicone mold, the mold itself having been formed using an electropolished acrylic, e.g. polymethyl methyl aery late (Lucite) master. This, (with the preferred casting composition referred to above) provides a smooth surface which minimizes platelet aggregation. Traditional molding methods such as injection molding or vacuum forming give rise to difficulties not experienced when an RTV silicone
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mold is used. Inj ection molding l eaves inherent stress points and weak spots in the pumping chamber. Vacuum forming results in very small irregul arities which can lead to platelet aggregation and bl ood cl ot formation.
Because of its peculiarly good resistance to cl ot formation and platelet aggregation, the particular copolymer heretofore described in conj unction with RTV sili cone mold pour casting, may also be used to produce artificial veins and arteries to be used ei ther al one or in conj unction wi th the LVAD of the present invention.
Such materials and methods lead to a very smooth, inert and controllably flexible product which produces only a minimum of platelet aggregation. This copolymer al so possesses longevity, leading to a minimum of complications due to apparatus fail ure from use. Further, as indicated above, the flexibility of the final product may be controllably moderated by the particular proportions of components used.
One aspect of this invention is the making of vascular system prosthetic devices, such as artificial heart chambers, veins, arteries, etc. by the method j ust described. The resultant products of this method are also another aspect of this invention. The method comprises, in general, making a prosthetic
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device for the vascular system by forming a positive acrylic master of the device and surface polishing the master. An RTV silicone negative mold is formed from the master, and the device is pour formed using the mold, by coating the mold with a mixture of aminobenzoate and diisocyanate. The resin is then cured such as by heat curing and removed from the mold. Preferably, the master is made from electropolished polymethyl methyl aery late (Lucite). The preferred polymeric resin is a mixture of polytetramethylene oxide-di-p-aminobenzoate and diphenylmethane diisocyanate (as previously indicated) .
In operation, diaphragm 41 is at rest in the position shown in Figure 2. Pumping chamber 20 is filled with blood. Electrical energy is applied via wire leads 59 to various windings 52a, 52b, and 52c. Each winding is individually actuable. The magnetic force thus generated is channeled through core 60 to repel diaphragm magnet 43. This repulsion causes a movement of diaphragm 41 to the position shown in shadow in Figure 2. This causes a reduction in volume of pumping chamber 20 and expels blood out through outlet port 32. By correctly shaping the electrical pulses supplied to various windings 52 a, b and c, the pulsatile pumping action of LVAD 10 may be made to simulate the pumping action of an actual heart ventricle, producing a pressure wave for an output
SUBSTITUTE SHEET
which is v ery similar to that produced by a natural heart ventricl e.
At this point , the el ectrical power is switched off. Permanent diaphragm magnet 43 is attracted to the non-magnetized ferromagnetic material in core 60 as well as the f erromagnetic material of flux shel l 51. Howev er , cor e cup magnet 58 is in a repul sion mode with diaphragm magnet 43. The attraction between diaphragm magnet 43 and the ferromagnetic material in actuator 50 is stronger than the repulsion created by core cup magnet 58. Diaphragm 41 begins to move toward actuator 50, increasing the vol ume of pump chamber 20 and drawing bl ood in through inl et port 31. The mov ement of diaphragm 41 toward actuator 50 is slowed by the increase in repul sion between core cup magnet 58 and diaphragm magnet 43.
This bipolar field effect (both attraction and repulsion being present at the same time) slows the movement of diaphragm 41 toward actuator 50. If this mov ement were too rapid, an undue strain would be placed upon the auricl e from which blood is drawn through inl et port 31. This bipol ar field effect also prevents a large magnetic attraction from building up between diaphragm magnet 43 and the f erromagnetic portions of actuator 50. Such a high magnetic attraction would be difficult to overcome for each
εucceeding pump cycle, and the pump operation would require large amounts of power. Instead, the power needed to repulse diaphragm magnet 43 and pump blood out of outlet port 32 is kept to a minimum, as are the power requirements of the overall operation of the
LVAD.
At rest, diaphragm 41 is fully extended toward actuator 50. An air gap 62 occurs between pusher plate magnet 43 and core cup magnet 58. The width of this air gap may be adjusted since, as previously explained, the actuator is held by threads into interface mount 45.
As shown in Figs. 1 and 2, interface mount
45 is equipped with interface mount ports 48. These ports allow air to flow freely in and out from between pusher plate magnet 43 and core cup magnet 58. When used as an LVAD, this air is supplied from an area surrounding the actuator and enclosed by an outer bag or jacket.
Claims
1. An apparatus for the pulsatile pumping of liquids comprising:
a pumping chamber having inlet and outlet valves, wherein one wall of said chamber comprises a flexible diaphragm, said diaphragm having a permanent magnet attached thereto, in coaxial alignment therewith; and
an electromagnet aligned such that when current is supplied to said electromagnet, a repulsive force is generated between said electromagnet and said diaphragm magnet, and when no current is supplied to said electromagnet, an attractive force exists between said electromagnet and said diaphragm magnet.
2. The apparatus of claim 1, wherein said chamber, diaphragm, permanent magnet and electromagnet have circular cross-sections and are coaxially aligned.
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3. The apparatus of claim 2, wherein said electromagnet comprises a ferromagnetic core and coil, said core comprising a truncated cone-shaped rear core section, cup-shaped front core section and a cup magnet,
said cup magnet being a permanent magnet and aligned such that a repulsive force exists between said cup magnet and said diaphragm magnet;
said cup magnet, rear core section and front core section being coaxially aligned.
4. An apparatus for simulating the pumping action of a ventricle of a heart comprising;
a pumping chamber including substantially unidirectional inlet and outlet valves, and a flexible diaphragm having a magnet attached thereto and coaxially aligned therewith, said diaphragm magnet being a permanent magnet; and
a second magnet coaxially aligned with said diaphragm magnet, said second magnet comprising a core and windings.
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5. The apparatus of claim 4 wherein said core comprises
a conical ly-shaped rear core section,
a cup-shaped front core section;
said diaphragm magnet being attracted to ° said core when said windings are not energized and repul sed by said core when said windings are energized.
5 6. The apparatus of Claim 5 wherein said windings comprise wire having a non-circular cross section.
0 7. The apparatus of claim 5 further comprising
a permanent cup magnet positioned to magnetical ly repul se said diaphragm magnet, said cup magnet located within said front core section; 5 wherein all of said diaphragm, diaphragm magnet, front core section, rear core section and permanent cup magnet are all in coaxial alignment. -21-
8. The apparatus of claim 7 wherein
when an appropriate pulse of electrical energy is applied to said windings, a net repulsive force is created between said core and said diaphragm magnet, forcing said diaphragm away from said core and decreasing the volume of said pumping chamber, producing a varying pressure in said chamber simulating the varying pressure in a heart ventricle.
9. A method for circulating blood in a body comprising:
implanting the apparatus of claim 4 in an animal body; and
supplying intermittent pulses of electricity to said windings.
10. An electromagnet comprising:
a core and windings;
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said core having a circular cross-section, said core comprising a conical ly-shaped rear core section, a cup- shaped front core section and a permanent cup magnet;
said front core section abutting said rear core section;
said front core section having a ferromagnetic section and a central hole;
said cup magnet being located in said front core hole;
said windings and said core being coaxially aligned.
11. The el ectromagnet of claim 10 further comprising a bobbin supporting said windings, said bobbin having an outer surface comprising a plurality of cylindrical sections having incrementally decreasing radii from a first end to a second end.
12. The electromagnet of claim 11 wherein said windings comprise wire having a non-circular cross section.
ET
13. An electromagnetic system comprising:
an electromagnet having a core and windings;
said core having a circular cross-section and comprising a conical ly-shaped rear core section, cup-shaped front core section, and a permanent cup magnet;
said front core section abutting said rear core section;
said front core section having a ferro- magnet section and a central hole;
said cup magnet being located in said front core hole;
said windings and said core being coaxially aligned; and
a permanent diaphragm magnet movable with respect to said electromagnet;
said system creating bipolar field effects between said diaphragm magnet and said electromagnet, when said electromagnet is deenergized.
TE SH
14. A pump comprising a pumping chamber including a movabl e diaphragm and a stati onary rigid pumping chamber wall, said chamber wall having substanti ally unidirectional inlet and outl et val ves, said chamber wall being asymmetrical such that fl uid contained in said pumping chamber pref erentially fl ows toward said outlet valve upon a rise in fluid pressure within said pumping chamber due to mov ement of said diaphragm.
15. The pump of claim 14 adapted to simul ate the pumping action of a ventricle of a human heart.
16. In combination, an el ectromagnet and a mating permanent magnet, positioned to be attracted to and repul sed by one another, al ong a line coaxial with said electromagnet and said permanent magnet upon activati on and deactivation of sai d el ectromagnet.
17. The combination of cl aim 16 wherein said el ectromagnet incl udes a core and windings, said core and windings being coaxially aligned with said electromagnet and said permanent magnet;
the cross-sectional area of said electromagnet, taken perpendicular to said coaxial line, varying inversely with the distance from said permanent magnet.
18. A ventricular assist device powered by a combination as recited in claim 16.
19. A ventricular assist device powered by a combination as recited in claim 17, said ventricular assist device further comprising a pump chamber having a moveable diaphragm and a fixed pump chamber wall, said permanent magnet being mounted to said moveable diaphragm, and said chamber wall having an asymmetric configuration such that when said permanent magnet is repulsed by said electromagnet, the volume of said pump chamber decreases and fluid therein is preferentially directed to an outlet port in said pump chamber wall.
20. The device of claim 19 wherein said pump chamber and diaphragm have a smooth surface resulting from pour casting said diaphragm and pump chamber wall in an RTV silicone mold.
21. The device of claim 20 wherein said pump chamber wall and diaphragm comprise copolymers of polytetramethylene oxide-di-p-aminobenzoate and diphenylm ethane diisocyanate.
22. A pump having a moveabl e diaphragm reciprocally activated by an electromagnet incl uding means to activate said el ectromagnet intermittently, and upon said electromagnet activation, to produce an el ectromagnet force causing said diaphragm to move away from said electromagnet, said pump including means for producing a bias f or ce tending to mov e sai d diaphragm toward said el ectromagnet.
23. The pump of claim 22 wherein said bias force means is a permanent magnet attached to said diaphragm and attracted to said el ectromagnet upon deactivation of said electromagnet.
24. The pump of claim 22 wherein said diaphragm comprises one wall of a pump chamber which includes a pump chamber wall , said pump chamber wall having an asymmetri cal configuration such that upon activation of said electromagnet, and a rise in pressure of fluid contained in said pump chamber, said fluid is preferen¬ ti ally directed toward an outl et port in said pump chamber wall.
TITUTE SHEET
25. The pump of claim 23 wherein said diaphragm comprises one wall of a pump chamber which includes a pump chamber wall, said pump chamber wall having an asymmetrical configuration such that upon activation of said electromagnet, and a rise in pressure of fluid contained in said pump chamber, said fluid is preferentially directed toward an outlet port in said pump chamber wall.
26. The pump of claim 24 wherein the chamber configuration, period of intermittency with which said electromagnet is activated, and configuration and strength of said electromagnet and said permanent magnet are selected, in combination, to produce upon said reciprocal operation of said diaphragm, a pulse action simulating that of a natural heart.
27. The pump of claim 25 wherein the chamber configuration, period of intermittency with which said electromagnet is activated, and configuration and strength of said electromagnet and said permanent magnet are selected, in combination, to produce upon said reciprocal operation of said diaphragm, a pulse action simulating that of a natural heart.
28. A method of making a prosthetic device for the vascular system by forming a positive acrylic master of the device and surface polishing said master, forming an RTV silicone negative mold from said master, and pour forming said device from said negative mold by forming on said negative mold a coating of polymeric resin, curing said resin to a polymer and removing said device from said mold.
29. A method, as recited in claim 28, wherein said polymeric resin is a mixture of polytetramethylene- oxide-di-p- aminobenzoate and diphenylm ethane diisocyanate.
30. A method, as recited in claim 29, wherein polytetramethylene oxide-di-p-aminobenzoate is Pol ami ne 1000.
31. A vascular system prosthetic device formed by the method of claim 28.
32. An el ectromagnet having a core and windings, said windings comprising wire having a non-circular cross section, disposed helically in side-to-side abutting relationship around said core.
33. The electromagnet of claim 32 wherein said core is formed from ferromagnetic material.
34. The electromagnet of claim 33 further including a bobbin disposed between said core and said windings.
35. A prosthetic vascular device comprising pour cast polytetramethylene oxide-di-p-aminobenzoate and diphenylmethane diisocyanate and adapted to be implanted in an animal body.
36. An electromagnetic coil comprising a helical winding of wire, said wire having a non-circular cross section.
37. The coil of claim 36 wherein said non- circular cross section is rectangular.
38. The coil of claim 36 further including a core about which said winding is wound, said core comprising a plurality of cylindrical segments of differing outer diameters.
39. The coil of claim 38, wherein said core comprises more than two cylindrical segments, said segments being coaxially aligned, successive segments along the coinci dent axis of said core being of progressively larger diameters.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/300,361 US5011380A (en) | 1989-01-23 | 1989-01-23 | Magnetically actuated positive displacement pump |
US300,361 | 1989-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1990008260A1 true WO1990008260A1 (en) | 1990-07-26 |
Family
ID=23158769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/000264 WO1990008260A1 (en) | 1989-01-23 | 1990-01-12 | Magnetically actuated positive displacement pump |
Country Status (3)
Country | Link |
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US (2) | US5011380A (en) |
CA (1) | CA2008163A1 (en) |
WO (1) | WO1990008260A1 (en) |
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WO1995031642A1 (en) * | 1994-05-18 | 1995-11-23 | Huntleigh Technology Plc | Diaphragm pump with magnetic actuator |
GB2295424A (en) * | 1994-05-18 | 1996-05-29 | Huntleigh Technology Plc | Diaphragm pump with magnetic actuator |
GB2295424B (en) * | 1994-05-18 | 1997-08-06 | Huntleigh Technology Plc | Diaphragm pump with magnetic actuator |
EP2298370A1 (en) * | 2002-02-21 | 2011-03-23 | Design Mentor, Inc. | Fluid pump |
WO2011141277A1 (en) * | 2010-05-11 | 2011-11-17 | Robert Bosch Gmbh | Metering pump |
US10398821B2 (en) | 2016-04-11 | 2019-09-03 | CorWave SA | Implantable pump system having an undulating membrane |
US11712554B2 (en) | 2016-04-11 | 2023-08-01 | CorWave SA | Implantable pump system having a coaxial ventricular cannula |
US11097091B2 (en) | 2016-04-11 | 2021-08-24 | CorWave SA | Implantable pump system having a coaxial ventricular cannula |
US11298522B2 (en) | 2016-04-11 | 2022-04-12 | CorWave SA | Implantable pump system having an undulating membrane |
US10933181B2 (en) | 2017-03-31 | 2021-03-02 | CorWave SA | Implantable pump system having a rectangular membrane |
US11623077B2 (en) | 2017-03-31 | 2023-04-11 | CorWave SA | Implantable pump system having a rectangular membrane |
US11512689B2 (en) | 2017-11-10 | 2022-11-29 | CorWave SA | Undulating-membrane fluid circulator |
US11446480B2 (en) | 2017-11-29 | 2022-09-20 | CorWave SA | Implantable pump system having an undulating membrane with improved hydraulic performance |
WO2019106493A1 (en) * | 2017-11-29 | 2019-06-06 | CorWave SA | Implantable pump system having an undulating membrane with improved hydraulic performance |
US10799625B2 (en) | 2019-03-15 | 2020-10-13 | CorWave SA | Systems and methods for controlling an implantable blood pump |
CN110251754B (en) * | 2019-07-05 | 2022-01-25 | 上海理工大学 | Double permanent magnet moving coil type blood pump |
CN110251754A (en) * | 2019-07-05 | 2019-09-20 | 上海理工大学 | Double permanent magnetic moving winding blood pumps |
US11191946B2 (en) | 2020-03-06 | 2021-12-07 | CorWave SA | Implantable blood pumps comprising a linear bearing |
WO2022182335A1 (en) * | 2021-02-23 | 2022-09-01 | Ventriflo, Inc. | Pulsatile fluid pump system |
Also Published As
Publication number | Publication date |
---|---|
US5302929A (en) | 1994-04-12 |
US5011380A (en) | 1991-04-30 |
CA2008163A1 (en) | 1990-07-23 |
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