WO1990014804A1 - Biological valvular prosthesis - Google Patents
Biological valvular prosthesis Download PDFInfo
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- WO1990014804A1 WO1990014804A1 PCT/US1990/003053 US9003053W WO9014804A1 WO 1990014804 A1 WO1990014804 A1 WO 1990014804A1 US 9003053 W US9003053 W US 9003053W WO 9014804 A1 WO9014804 A1 WO 9014804A1
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- Prior art keywords
- valve
- valvular prosthesis
- biological
- prosthesis
- conduit
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2475—Venous valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
Definitions
- the present invention is directed to biological valvular prosthesis and to methods of making the same.
- the present invention is directed to valvular prostheses formed from chemically fixed biological venous valve segments.
- These valvular prostheses contain one or more venous valves, with each venous valve having two or more leaflets chemically fixed in a position to ensure that the leaflets open under minimal forward blood flow pressures, but close under the application of backflow pressure.
- the biological valvular prosthesis of the invention there are different embodiments of the biological valvular prosthesis of the invention, each of which has a different type of application.
- the biological valvular prostheses are useful in applications which require the replacement of a valve.
- one application involves the replacement of a defective or diseased venous valve.
- the valvular prosthesis is used for correcting truncus arteriosus, a congenital defect where the pulmonary and aortic arteries join to form a single artery having a single valve.
- the pulmonary and aortic arteries are surgically separated to isolate the blood flow.
- the valvular prosthesis of the invention is used to route blood from the right ventricle to the pulmonary artery.
- the integral valve of the valvular prosthesis functions as the semilunar valve normally present at the base of the pulmonary artery.
- Venous valves are valves located in the veins. Blood circulates from the arterial to the venous system, with the blood pressure greatest in the arterial system. Blood pressure, as provided by heart activity in the arteries, is normally sufficient to maintain the flow of blood in one direction. The pressure of the blood in the veins is much lower than in the arteries principally due to the distance from the heart.
- the primary benefit of venous valves is the ability to limit backflow of blood traveling through the venous system. Numerous venous valves are located throughout the veins ensuring that the blood travels through the veins towards the heart.
- the normally low blood pressure in the venous system is supplemented by the contraction of skeletal muscles.
- the contraction of the muscles compresses and drives the blood through the veins.
- the venous valves check blood flow through the veins, ensuring the drive of the blood towards the heart. Any damage to the venous valves disrupts this normal blood flow.
- Venous valves also evenly distribute blood in the veins by segregating portions of blood flowing through the venous system.
- a further benefit provided by venous valves is checking the backflow of blood through the veins which minimizes or reduces the effect of a sudden increase in blood pressure, e.g. upon heavy exertion.
- Venous valves are particularly important in the lower extremities, e.g. legs.
- the venous system in the lower extremities generally consists of deep veins and superficial veins which lie just below the skin surface.
- the deep and superficial veins are interconnected by perforating veins. Blood generally flows upwards through the legs towards the heart, and from the superficial to deep veins.
- the venous valves are situated in the deep, superficial and perforating veins to ensure the direction of blood flow.
- Venous valves can become incompetent or damaged by disease, e.g. phlebitis, injury or a result of inherited malformation. Incompetent or damaged valves usually leak blood, even at low blood pressures. These valves fail to prevent the backflow of blood, which is particularly troublesome in the veins of the lower extremities.
- Valvuloplasty involves the surgical reconstruction of the valve.
- Transposition of veins involves surgically bypassing sections of veins possessing the incompetent or damaged valves with veins possessing viable valves.
- Transplantation involves surgically transplanting one or more of a patient's viable - 4 -
- Venous valves are usually damaged during handling wten the venous valve is being reconstructed, transpositioned or transplanted.
- the endothelium tissue layer of the vein may also be damaged during handling. This reduces the viability of the vein graft after implant.
- Xenograft monocusp patches were examined for possible use in repairing incompetent venous valves, see "Femoral Vein Valve Incompetence: Treatment with a Xenograft Monocusp Patch", Raul Garcia-Rinaldi , M.D., Ph.D., J.M. Revuelta, M.D., Ph.D., Manuel Martinez, M.D., Enrique Granda, M.D. and Luis De Santos, M.D., Journal of Vascular Sur ⁇ erv. Vol. 3, pages 932-935 (1986). While these workers found some success in the implantation of patches, they recognized the advantage of a truly prosthetic device for replacement of incompetent venous valves.
- a titanium venous valvular prosthesis has been suggested by Taheri .
- This valvular prosthesis is discussed more fully in "Experimental Prosthetic Vein Valve", Syde A. Taheri et al , The American Journal of Surgery. Vol. 156, pages 111-114 (1988).
- the major disadvantage with this type of prosthesis is hemolysis and thrombosis. Damage to the blood as it flows through the valve is enhanced by the small diameter of the valves. Use of such valves requires treatment of the patient with anticoagulants.
- Prosthetic heart valves and vascular grafts are commercially available. Such devices may be constructed from artificial and natural materials. Natural tissues used for the construction of prosthetic devices are usually preserved, or fixed in a suitable chemical tanning procedure.
- Chemical tanning procedures serve to preserve the tissue to minimize deterioration after implantation, and reduce the possibility of rejection of the device by the host.
- natural tissues may be treated with a glutaraldehyde solution, with such processes taught in U.S. Patent Numbers 4,372,743, issued to Lane on February 8, 1983; and 3,966,401, issued to Hancock et al on June 29, 1976.
- the process taught in Lane involves a low pressure fixation prooess. This process reduces damage to the valve leaflets during the fixation process.
- the Hancock et al process involves the alternating pulsation of pressure within the heart valve or vessel .
- Examples of prosthetic heart valves constructed at least partially from biological tissue are generally disclosed in U.S. Patent Nos. 3,736,598, issued to Bellhouse et al on June 5, 1973; 2,832,078, issued to Williams on April 29, 1958; 4,451,936, issued to Carpentier et al on June 5, 1984; and 4,725,274, issued to Lane et al on February 16, 1988.
- Prosthetic vascular grafts are also known. Examples of vascular grafts or blood vessels prepared from artificial materials are disclosed in U.S. Patent Nos. 4,086,665, issued to Poirier &i May 2, 1978; 4,118,806, issued to Poirier on October 10, 1978; and 4,670,286, issued to Nyilas et al on June 2, 1987.
- the artificial blood vessels taught in the Poirier references may include porcine xenograft valves.
- the inclusion of the, valve is required when the artificial blood vessel bypasses a natural heart valve.
- the main disadvantage with using the vascular graft containing a procine xenograft valve, as described in the Poirier references, is the development of luminal deposits of fibrinous material after a period of time. The development results from the synthetic grafts positioned on either side of the valve.
- Vascular grafts may also be prepared from natural tissues. Such grafts are prepared by chemically treating segments of biografts. Examples of these grafts are disclosed in U.S. Patent Nos. 4,671,797, issued to Vrandecic Pedero on June 9, 1987 and 4,466,139, issued to Ketharanathan on August 21, 1984. Hancock et al also discloses the preparation of veins and arteries.
- bioprosthetic heart valves and vascular grafts are known, bioprosthetic venous valves are presently not available.
- the major deterrent in constructing venous valves is the need to provide a valve which remains normally open, but closes under slight backflow.
- Another deterrent in constructing such valves is the need to provide proper valve leaflet and sinus geometry as the valve opens and closes.
- Prosthetic heart valves and the methods of preparing the same, are not suitable as venous valve replacements.
- the unsuitability of using prosthetic cardiac valves ' as replacements for venous valves was discussed in the article by Gerlock et al .
- Prosthetic heart valves are usually made from porcine valves.
- Porcine heart valves have a geometry unsuitable as a replacement for venous valves.
- These types of valves are also generally larger than venous valves, and include valve leaflets generally thicker and stiffer than the leaflets of venous valves. The thicker heart valve leaflets require a greater opening pressure. The greater required opening pressure makes such valves unsuitable for the venous system.
- the techniques used to prepare prosthetic heart valves make the resulting prosthesis more unsuitable for use as a venous valve replacement. As stated, venous valve leaflets are thinner and must remain open under normal venous flow conditions.
- the techniques used to prepare cardiac valvular prosthesis fix the leaflets to remain normally closed, and to open only upon the exertion of relatively higher pressures. These tanning techniques also form stiffer leaflets which further require greater pressures to open the valve.
- a further application for the valvular prosthesis of the invention is in the treatment of congenital defects of the right ventricular outflow tract.
- a valvular prosthesis in* the form of a tubular member bearing at least one venous valve may be used to bypass a defective semilunar valve of the pulmonary artery, or even a defective pulmonary artery.
- ExampT&s of defects of the right ventricular outflow tract are truncus arteriosus, pulmonary atresia and pulmonary stenosis.
- Truncus arteriosus is a congenital cardiovascular malformation where a single artery, formed by the joining of the pulmonary and aortic arteries, arises from the heart. This single artery typically bridges the right and left ventricles. This congenital defect may also be accompanied by a ventricular septal defect, which is a hole through the heart wall between the right and left ventricles.
- One technique utilizes a homograft which is surgically interposed in a graft sutured between the right ventricle and the pulmonary artery.
- a homograft which is surgically interposed in a graft sutured between the right ventricle and the pulmonary artery.
- Another surgical procedure involves the construction of a bypass from the right ventricle to the pulmonary artery segment using a pericardial tissue patch. A pericardial monocusp is formed in the bypass.
- a major disadvantage to the above discussed surgical procedures for the repair of truncus arteriosus is the use of multiple components in the reconstruction of the various arteries from the single large artery. That is, the first described procedure requires the use of a homograft and vascular graft, typically constructed from polytetrafluoroethylene, while the second procedure requires the use of a pericardial patch and a pericardial monocuspid. These procedures require extensive surgical implantation time, and provide sites for hemolysis. While these discussed surgical procedures provide some relief from this debilitating congenital defect, improvements in the surgical techniques and prosthesis are necessary.
- the present invention overcomes the above discussed disadvantages by providing a biological valvular prosthesis formed from a biologically derived conduit having at least one tissue- valve with leaflets prepositioned to open under normal forward blood flow conditions, but close under minimal backflow pressure, while maintaining the natural geometry of the valve.
- the biological valvular prosthesis is formed from a harvested vein segment including one or more venous valves which is chemically fixed to ensure that the leaflets remain open under minimal forward blood flow, while closing under minimal backflow.
- the venous valves are chemically fixed with the valve leaflets retained in either the open or closed position. It has been found that in order to ensure a normal opening of the valve leaflets, that the fixation be performed while the leaflets are preferably retained in a substantially open position. The chemical fixation is also performed to ensure that the valve leaflets remain substantially supple so as to close upon minimal backflow pressure.
- the biological valvular prosthesis and method of preparing the same provides substantially supple valve leaflets that remain substantially open during normal forward blood flow.
- these flow rates are at least from about 100 Brilliliters per minute (ml/m), preferably from about 250 to about 550 ml/m, but will close under a minimum backflow pressure, generally a pressure of at least 0.1 millimeters of Mercury (mm Hg).
- the precise configuration of the valvular prosthesis of the invention is dependent upon the desired application.
- the harvested venous valve segment includes the individual valves situated in a vein segment.
- the vein segments are cut back at each side of the valve to within a few centimeters of the valve.
- the resulting prosthesis is a fixed venous valve having only a sufficient amount of the vein segment retained at opposite sides to provide a suture site.
- the precise length of the retained segments should only be sufficient to minimize the potential of suturing the leaflets during the implantation.
- the implantation of this valvular prosthesis involves cuting the vein into two portions and inserting this prosthesisis between these portions.
- Another embodiment useful for replacing a patient's venous valve involves removing the valve sinus regions.
- This prosthesis is surgically sutured into the patient'.s vein.
- This embodiment utilizes a portion of the patient's vein to function as the sinus.
- the segments at both sides of the valve are retained to form a tubular prosthesis having one or more valves.
- the valvular prosthesis of this embodiment may be used to bypass a defective venous valve or replace a defective heart valve.
- a particularly advantageous use of this tubular prosthesis is in the reconstruction of the pulmonary artery to correct various types of congenital heart defects.
- the biological valvular conduit prosthesis may be reinforced about the extended vein segments to prevent collapse of such segments. The ends of this conduit may be provided with sewing rings, or other means to facilitate suturing.
- One particular congenital heart defect for which the tubular conduit valvular prosthesis may be used is in the correction of truncus arteriosus.
- One of the vein segments is modified by cutting the segment lengthwise to form a flap-like extension.
- this flap portion is sutured about an incision made in the heart wall of the right ventricle, with the opposite end of the valvular conduit sutured to the pulmonary segment which was isolated from the aortic segment.
- FIGURE 1 is a partial section prospective view of a venous valvular replacement prosthesis in accordance with an embodiment of the invention
- FIGURE 2 is an end on view of the venous valvular replacement prosthesis of FIGURE 1 viewing the leaflets in a closed position;
- FIGURE 3A is a cross-section view of the venous valvular replacement prosthesis of FIGURE 1 with the leaflets in the closed position;
- FIGURE 3B is a cross-section view of the venous valvular replacement prosthesis of FIGURE 1 with the leaflets in the open position;
- FIGURE 4 is a cross-sectional view of a venous valvular replacement prosthesis with a support cage positioned about the segment;
- FIGURE 5 is a prospective view of a support
- FIGURE 6 is a prospective view of another type of support cage
- FIGURE 7 is a schematic illustration of the apparatus arrangement for preparing a biological valvular prosthesis in accordance with an embodiment of the invention
- FIGURE 8 is a prospective view of a venous valvular replacement prosthesis in accordance with another embodiment of the invention.
- FIGURE 9 is a prospective view of a vein incorporating the prosthesis of FIGURE 8.
- FIGURE 10 is a side view of another type of support cage
- FIGURE 11 is a partially sectioned view of a venous valvular replacement prosthesis incorporating the support cage of FIGURE 10;
- FIGURE 12 is a prospective side view of a biological valvular conduit prosthesis in accordance with an embodiment of the invention.
- FIGURE 13 is a cross-sectional view of the valvular conduit prosthesis of FIGURE 12;
- FIGURE 14 is a side prospective view of a biological valvular conduit prosthesis in accordance with another embodiment of the invention.
- FIGURE 15 is a side prospective view of a biological valvular conduit prosthesis in accordance with a further embodiment
- FIGURES 16A-C are illustrations of a modified valvular conduit prosthesis used for repair of truncus arteriosus
- FIGURES 17A-C are illustrations of the surgical correction of truncus arteriosus using the valvular prosthesis illustrated in FIGURES 16A-C.
- the present invention concerns biological valvular prostheses and methods of making the same.
- the valvular prosthesis has use in various applications, e.g. the replacement £>f venous valves or the repair of the congenital defect truncus arteriosus.
- the valvular prosthesis of the invention is constructed by chemically fixing a vein segment containing one or more venous valves.
- the source of the vein segment may be equines, bovines, caprines or ovines.
- the valvular prosthesis of the invention has many applications.
- the exact configuration of the prosthesis will depend upon the desired application.
- the vein segment at either side of the venous valve may either be retained or excised depending upon the final application.
- the various applications for the valvular prosthesis of the invention requires that the valve leaflets be fixed to remain substantially open under normal blood flow, but close under minimal backflow. This is particularly important when the valvular prosthesis of the invention is used as a venous valve replacement.
- venous valves Unlike cardiac valves, venous valves normally remain open, and close upon the exertion of any backflow pressure. This distinction between cardiac and venous valves requires a different type of valve and different preparation procedures.
- the valvular prosthesis of the invention are prepared with leaflets prepositioned to remain open under normal forward blood flow and close under backflow pressure.
- normal forward blood flow it is meant that level of blood flow through the particular vein. Blood flow rates vary between different veins, but generally will be greater than at least about one hundred miHiliters/minute.
- backflow it is meant the direction away from the normal forward blood flow, and in particular the flow direction away from the heart or away from the deep veins. Generally, the necessary backflow to close the valves will provide a pressure of at least 0.1 mm Hg.
- the valvular prosthesis of the invention will remain substantially open under normal forward blood flow.
- the valves will remain greater than about 70 percent open, preferably greater than about 80 to 90 percent open under normal forward blood flow.
- the valvular prosthesis of the invention is prepared from harvested vein segments containing one or more venous valves.
- Preferable vein segments are jugular veins from equines, bovines, caprines and ovines.
- the vein segments used for the purpose of the invention may have one or more intact valves.
- a harvested segment having more than one valve may be subdivided for the preparation of one or more venous valvular prosthesis.
- any extraneous material e.g. muscle and fatty deposits and tissue is removed from about the vein.
- a minimal amount of the segment remains extending out from either side of the valve.
- the precise length of the segment which extends out from both sides of the valve is dependent upon the particular application for the prosthesis. In certain applications only a few centimeters of the segment will be retained, while for another application the retained segments are longer.
- Tanning is a well known process involving the treatment of the vessel with an aldehyde solution or other suitable fixative, typically a solution of glutaraldehyde in pH balanced electrolyte buffer. It has been found that the concentration of glutaraldehyde should be from about 0.025 percent to about 0.626 percent of the tanning solution to prepare the supple valve leaflets of the invention.
- aldehyde solution or other suitable fixative typically a solution of glutaraldehyde in pH balanced electrolyte buffer. It has been found that the concentration of glutaraldehyde should be from about 0.025 percent to about 0.626 percent of the tanning solution to prepare the supple valve leaflets of the invention.
- Venous valvular replacement prosthesis 10 is a harvested tubular blood vessel 12 containing at least one intact-venous valve, seen generally at 14.
- Valve 14 may be of the bileaflet or trileaflet type, with the typical type being bileaflet.
- the illustrated venous valvular replacement prosthesis 10 contains a single bileaflet valve 14.
- the original blood vessel segment from which the prosthesis 10 was formed may have included more than one venous valve. However, for this embodiment the original blood vessel segment is cut into individual segments containing separate venous valves. It should be noted that in other embodiments the prosthesis is formed by retaining the multiple valves in a single conduit.
- the venous valvular replacement prosthesis TO includes a single bileaflet valve 14. This bileaflet valve 14 includes two leaflets, seen at 16 and 18 respectively.
- valve leaflets 16 and 18 are positioned to slightly overlap when the valve is closed, as better seen in Figure 2.
- the venous valvular replacement prosthesis 10 is prepared to minimize any interference with this natural overlapping relationship.
- the venous valvular replacement prosthesis 10 is prepared to ensure that the bileaflet valve 14 remains substantially open during normal forward blood flow through the prosthesis 10.
- the valve leaflets 16 and 18 also remain substantially supple to promote closure of the bileaflet valve 14 under any backflow pressure, generally backflow pressures in excess of 0.1 mm Hg.
- the venous valvular replacement prosthesis 10 of the invention is formed to allow the leaflets 16 and 18 to remain supple enough to close under the minimal application of backflow pressure while remaining open during normal forward blood flow. These characteristics allow the venous valvular replacement prosthesis 10 to generally mimic the functioning of natural venous valves.
- the process by which the venous valvular replacement prosthesis 10 is prepared prepositions the valve leaflets 16 and 18 in a substantially open position.
- the fixing of the leaflets 16 and 18 in a substantially open position ensures that the valve will remain substantially open, that is at least 70 percent open during forward blood flow.
- the leaflets 16 and 18 are fixed in either a closed or partially open position. While the resulting prosthesis remains open under normal forward blood flow, the leaflets do not open to as great a degree as when the leaflets 16 and 18 are fixed in an open position.
- the preferred embodiment fixes the valve leaflets 16 and 18 in a substantially open position.
- the chemical fixing of the valve leaflets 16 and 18 in a substantially open position is provided by subjecting the harvested and cleaned blood vessel containing the venous valve to a tanning process while maintaining a substantially constant flow of tanning fluid, that is the aldehyde solution, through the blood vessel.
- the leaflets 16 and 18 may also be chemically fixed while retained in a partially open position.
- the extent to which the valve leaflets are open is controlled by varying the flow rate of the tanning solution through the blood vessel during the fixation process.
- the resulting prosthesis will have the leaflets fixed anywhere from completely open to about 10 to 70 percent of the normal open position of the valve.
- the process by which the blood vessel containing the venous valve is treated to prepare the venous valvular replacement prosthesis 10 is similar to those tanning procedures used to prepare cardiac heart valves.
- One specific process is disclosed in U.S. Patent Numbers 4,372,743, with the description of the general process for treating animal tissue by the use of aldehyde, and specifically glutaraldehyde being incorporated herein by reference.
- a tanning procedure useful for preparing the venous valvular replacement prosthesis 10 in accordance with the preferred embodiment of the invention will be described with reference to Figure 7.
- a blood vessel containing one or more venous valves is harvested from a subject animal.
- the blood vessel is a bovine, equine, caprine or ovine external or internal-jugular vein.
- the harvested blood vessel may contain more than one venous valve.
- the bovine internal or external jugular veins includes about 2 valves per vein segment.
- the blood vessel is cleaned and divided into segments containing single valves. The size of the vein segments at both sides of the valve is reduced. As stated, the length of the blood vessel on either side of the valve will be less than about 0.5 cm, preferably about 1 cm to about 3 cm from valve aggar, and about 1 cm to about 2 cm from the valve commissures.
- the harvested blood vessel is then cleaned and if desired stored in a balanced physiological electrolyte solution for less than 24 hours prior to being subjected to the chemical tanning process.
- the tanning apparatus useful for preparing the valvular prosthesis of the invention is seen generally in Figure 7.
- This apparatus includes two fluid tanks 20 and 22.
- the first fluid tank 20 will contain the tanning solution which will be circulated through the blood vessel.
- the blood vessel seen generally at 24, will be held within the second fluid tank 22.
- the second fluid tank 22 will be filled with additional tanning solution.
- the blood vessel 24 is mounted upon a support, seen generally at 26.
- Support 26 includes two opposing stoppers 28 and 30. Each of the stoppers 28 and 30 is formed to fit snuggly within an end of the blood vessel 24.
- the stoppers 28 and 30 are also formed with passageways, not shown, which traverse through each of the individual stoppers 28 and 30.
- the stoppers 28 and 30 are further formed to allow individual pieces of tubing, seen generally at 32 and 34 to be coupled together.
- Tubing 32 is also connected to a pumping mechanism seen generally at 36.
- This pumping mechanism 36 may be any suitable type of device which can pump fluid . through a tubing.
- pumping mechanism 36 may be a magnetic-driven centrifugal pump or master flex pump.
- Tubing 34 is coupled at its other end to the first fluid tank 20.
- a third piece of tubing, seen generally at 38, is coupled between the first fluid tank 20 and pumping mechanism 36.
- the combination of the first fluid tank 20, pumping mechanism 36 and tubing 32, 34 and 38 form a continuous, uninterrupted fluid pathway when the blood vessel 24 is connected to the support 26.
- Both the first fluid tank 20 and second fluid tank 22 are filled with a tanning solution.
- this tanning solution is an aldehyde solution containing from about 0.10 percent to about 1.0 percent of an aldehyde, with the remaining solution being a pH balanced physiological electrolyte solution.
- the aldehyde is glutaraldehyde.
- Other suitable tanning solutions include acrolein or polyepoxy compounds.
- the tanning solution in the second fluid tank 22 is maintained at atmospheric pressure. However, if desired, this tanning solution can be placed under pressure by sealing the second fluid tank 22 and circulating the fluid within the second fluid tank 22, or circulating the fluid between the second fluid tank 22 and another tank, not shown.
- the rate at which the tanning fluid is circulated through the blood vessel 24 is dependent upon the extent to which the leaflets are to be prepositioned in an open state. This prepositioning ensures that the valve leaflets 16 and 18 will remain open during normal forward blood flow through the venous valvular replacement prosthesis 10. Depending upon the flow rate of the tanning fluid, the valve leaflets 16 and 18 will be prepositioned to greater than about 70 percent of their open position, preferably greater than about 80 to 90 percent.
- a further requirement for the tanning process is to provide that the valve leaflets 16 and 18 will remain substantially supple.
- This suppleness allows the valve leaflets 16 and 18 to close under a minimal backflow.
- This suppleness is achieved by controlling the concentration of the glutaraldehyde in the tanning solution and the amount of time the blood vessel is subjected to the tanning solution. It has been determined that the concentration of aldehyde in the tanning solution, and the amount of time to which the tissue is subjected to the tanning solution affects the stiffness of the tissue.
- the aldehyde concentration and tanning time also controls the degree of the bio burden reduction. That is, the bio burden or bacterial growth on the tissue must be reduced below an acceptable level. This level is controlled by the amount of time to which the tissue is subjected to the tanning process.
- the concentration of the aldehyde, i.e. glutaraldehyde, in the tanning solution should be from about 0.025 percent to about 0.626 percent of the tanning solution to prepare the supple valve leaflets of the invention.
- the glutaraldehyde should be about 0.15 percent of the tanning solution to ensure proper suppleness of the leaflet.
- the tanning solution within the first fluid tank 20 is circulated through the blood vessel 24 at a rate of from about 0.5 liters/minute (1/m) to about 4 1/m.
- the fluid is circulated at a rate of from about 1 1/m to about 3 1/m.
- the applied pressure is the measured pressure differential across the valve. This pressure differential is measured by taking the difference of the fluid pressure entering over the fluid pressure exiting the blood vessel during the tanning process.
- the amount of time in which the blood vessel 24 is subjected to the tanning procedure will also effect the extent to which the valve leaflets 16 and 18 close.
- the blood vessel 24 is subjected to the tanning process for a sufficient amount of time to attain the desired bio burden and provide for fixed leaflets that remain substantially open under normal forward blood flow while closing under the application of backflow pressure.
- the exact time is dependent upon the nature of the tissue forming the leaflets and degree of bio burden present on the tissue.
- the tanning procedure lasts from about thirty minutes to about four hours, preferably from about two to three hours, and more preferably about three hours.
- Fixing the leaflets in the closed position is performed by reversing the flow of the tanning solution through the blood vessel and maintaining a minimal pressure against the valve leaflets.
- the pressure applied against the closed leaflets should be around about 0.1 mm Hg.
- Figures 3A nd 3B are schematic llustrations of a venous valvular replacement prosthesis 10.
- Figure 3A illustrates a venous valvular replacement prosthesis 10 with the valve leaflets 16 and 18 moving into a closed position.
- Figure 3B illustrates a venous valvular prosthesis with the valve leaflets 16 and 18 in a substantially open position.
- each of the valve 1-eaflets 16 and 18 is a sinus, seen respectively at 40 and 42.
- Each sinus 40 and 42 is generally bulbous in shape and defines a sinus cavity 44 and 46 respectively.
- the sinus cavity 44 and 46 With blood flowing in a normal direction through the venous valvular replacement prosthesis 10, as seen in Figure 3B, the sinus cavity 44 and 46 remain substantially empty of blood with the sinus 40 and 42 being somewhat flat.
- the sinus cavity 44 and 46 begin to fill with blood.
- the filling of the sinus cavity 44 and 46 causes the associated sinus 40 and 42 to bulge outward from the venous valvular replacement prosthesis 10 and begins to force the individual valve leaflets 16 and 18 into a closing position.
- the venous valvular replacement prosthesis 10 is further provided with a supporting cage.
- This supporting cage is generally seen in Figure 5 at 48.
- Cage 48 will be positioned around the exterior of the venous valvular replacement prosthesis 10.
- the supporting cage 48 functions to control the dilation of the bileaflet valve 14 during pressure increases ' with the associated blood vessel. The proper positioning of the supporting cage 48 minimizes the dilation of the bileaflet valve 14 and the possible incompetence of the venous valvuJar replacement prosthesis 10.
- the construction of the supporting cage 48 is designed to not interfere with the normal operation of the venous valvular replacement prosthesis 10.
- the supporting cage 48 is designed not to restrict the normal filling of the sinus cavity 44 and 46.
- the supporting cage 48 will restrict further expansion of the sinus cavity 44 and 46. This will limit the extent to which the bileaflet valve 14 dilates and prevent the bileaflet valve 14 from becoming incompetent.
- the supporting cage 48 is formed from two circular collars 50 and 52 which are linked by struts 54 and 56.
- the collar 50 will be positioned about the venous valvular replacement prosthesis 10 at the upstream side of the bileaflet valve 14, while the collar 52 will be positioned at the downstream side.
- the diameter of the side of the venous valvular replacement prosthesis 10 upstream from the bileaflet valve 14 is smaller than the diameter of the downstream side.
- the collar 50 is smaller than collar 52.
- the individual collars 50 and 52 are dimensioned to provide for a snug fit about the corresponding location of the venous valvular replacement prosthesis 10.
- the positioning of the struts 54 and 56 is also critical. As seen in Figure 2 the valve leaflets 16 and 18 are different sizes. The associated sinus cavity 44 and 46 are of similar size differences. The struts 54 and 56 are fixed between the collars 50 and 52 so as not to interfere with the filling of the sinus cavity 44 and 46.
- Cage 60 includes two collars 62 and 64 similar in size and positioning as collars 50 and 52 for cage 48.
- the main difference between cages 48 and 60 is that cage 60 includes a plurality of outwardly bowed ribs or struts, one of which is seen at 66.
- the number of struts 66 may vary from 4 to 6 equidistantly positioned about the circumference of the cage 60.
- the struts 66 are formed with a sufficient enough outward curvature to allow for the expansion of the sinus during backflow, as better seen in Figure 6B.
- the curvature of the struts 66 will not interfere with the operation of the valve during normal forward blood flow as seen best in Figure 6A.
- a single upstream collar may be used in place of the supporting cage 48.
- This single upstream collar is seen in phantom at 58 in Figure 3A.
- the positioning of the collar 58 at the upstream position restrains the dilation of the venous valvular replacement prosthesis 10. If the venous valvular replacement prosthesis 10 restrained downstream from the bileaflet valve 14, the valve 14 could still dilate.
- Another embodiment of a support cage is seen in Figure 10 at 100.
- This support cage 100 is a generally tubular structure having a first cylindrical section 102 out from which extends an outwardly flaring section 104. This outwardly flaring section 104 is shaped to conform to the outer configuration of the valves sinus.
- a still -. further embodiment of the invention is a modification of the venous valvular prosthesis. This modification, which is seen in Figures 8 and 9, involves removing the tissue defining the valve sinus areas. The tissue is removed only for the sinus area leaving intact the valve commissures and leaflets. The resulting structure is seen more generally in Figure 8 at 70.
- the valvular prosthesis 70 includes the aggar portion of the valve with a small portion of the blood vessel tube extending out therefrom, as seen at 72.
- the prosthesis 70 also includes the intact leaflets 74 and 76, as well as the commissures 78 and 80. A small portion of the vein wall juxtapositioned the commissures remains intact as seen generally at 79 and 81.
- a further modification of this embodiment involves excising a single valve leaflet and a small portion of the vein wall to form a monocuspid prosthesis. This monocusp may then be surgically implanted in a venous valve which possess a single damaged or diseased leaflet.
- Figure 9 illustrates the prosthesis 70 of Figure 8 as sutured into a vein lumen 73.
- the described monocuspid may be substituted for the prosthesis 70 where only a single leaflet is damaged or diseased.
- the valvular prosthesis of the invention may also be configured to form a valvular conduit prosthesis containing one or more valves.
- This embodiment of the invention involves retaining a portion of the vein segment at both sides of the valve.
- One embodiment of the valvular conduit prosthesis is seen generally at 110 in Figures 12 and 13.
- the valvular conduit prosthesis 110 includes a biological vein segment 112 which is chemically fixed as discussed above.
- the difference between the process of preparing this valvular conduit 110 and the prosthesis 10 described above is the retention of portions 114 and 116 of the fixed valve segment which extend out from either side of the venous valve 118.
- the vein segments extending out from the valve will be greater than about 3 cm below the aggar and greater than about 2 cm above the valve commissures, preferably greater than about 5 cm in either direction.
- the fixed vein portions 114 and 116 may be supported or reinforced to reduce possible collapse of such segments 114 and 116 during and after implantation.
- the biological vein segment 112, and in particular the portions 114 and 116, as seen in Figures 12 through 14 is supported by a cloth tube 120 wrapped either about the entire segment 112, or each of the individual portions 114. If the tube 120 encapsulates the entire vein segment 112, then it is dimensioned in the region of the valve 118 to allow dilation of the valve sinus.
- the cloth tube 120 may be formed from Dacron, polytetrafluoroethylene, or other suitable biologically compatible materials. Tube 120 is generally constructed by wrapping a cloth about the biological vein segment 112 or individual portions 114 and 116.
- the valvular conduit 110 is further provided with a support cage 124 of similar construction and design to support cage 48 or 100 described above for the venous valvular replacement prosthesis 10. Additional support may be provided by fixing one or more individual reinforcing rings 122 about the prosthesis 110.
- Other embodiments of the valvular conduit prosthesis are seen generally in Figures 14 and 15. All of the elements of the valvular conduit prosthesis seen in Figures 14 and 15 are the same as that described for the prosthesis 110 shown in Figures 12 and 13, except for the reinforcing rings 112. In the embodiment shown in Figure 14, the individual reinforcing rings 112 are replaced by single spiral reinforcing members 126 and 128 positioned at opposite sides of the venous valve 118.
- the valvular conduit prosthesis 110 includes the cage 124.
- FIG. 15 is a further variation in which the individual reinforcing rings 112 are replaced by single support members 130 and 132 positioned at opposite sides of the venous valve 118.
- These support members 130 and 132 are essentially conduits formed with a plurality of cutaways 134. Cutaways 134 are generally rectangular in shape and arranged in alternating off center rows. This arrangement provides the support members 130 and 132 with greater flexibility than would be obtained with a solid tubular member.
- Other possible configurations for the supporting of the segments 114 and 116 would be apparent to those skilled in the art.
- the biological valvular conduit prosthesis 110 may be used anywhere a valve is required in the circulatory system. For example, this prosthesis 110 may be inserted into the patient's vein to bypass a defective venous valve, in lieu of interposing the described venous valvular prothesis 10 in a patient's vein.
- the valvular conduit prosthesis 110 may also be used to reconstruct the pulmonary artery during the correction of various types of congenital birth defects of the right ventricular outflow tract. Examples of such defects include truncus arteriosus, pulmonary atresia and pulmonary stenosis.
- a valvular conduit prothesis 136 prepared as described above, is formed with two segments 138 and 140 extending out from either side of the venous valve 142. These segments are formed by retaining an extended portion of the valve segment at either sido of the valve after the fixation process. One of these segments 138 remains essentially unaltered after fixation and retained as a tubular body. The other segment 140 is cut lengthwise to form two portions. The cut is brought to within about two to about five centimeters of the valve. One of the portions is removed leaving only remaining portion to define a flap-like extension.
- Valvular conduit prosthesis 136 has particular utilization in the reconstruction of the pulmonary artery in individuals suffering from truncus arteriosus.
- Truncus arteriosus is a congenital defect where a single artery arises from the heart in lieu of two separate arteries, the pulmonary and aortic.
- the artery * communicates with both the left and right ventricles.
- a spatial defect is normally present with this defect. Blood entering the right ventricle, which normally passes to the lungs via the pulmonary artery, will pass through this defect directly into the left ventricle. Blood will also pass out of the right ventricle via the enlarged artery and travel through both the pulmonary and aortic segments. The result is the passage of unoxygenated blood to the aortic segment from the right ventricle.
- the reconstruction of a heart having this congenital defect will now be described with reference to Figures 17A-C.
- the first step typically involves surgically dividing the large single artery into the two individual aortic and pulmonary arteries, as seen in Figure 17A at 150 and 152.
- a patch is suturecf over the ventricular septal defect, typically a pericardial patch, seen at 154 in Figure 17B.
- the aortic segment is also sealed with a patch, again typically a pericardial patch, seen at 156 in Figure 17A.
- a connection between the right ventricle 158 and the pulmonary artery segment 152 is provided using the valvular conduit prosthesis 136.
- An opening 160 is made in the heart wall defining the right ventricle 158.
- the flap-like segment 140 of the valvular conduit prosthesis 136 is sutured to the right ventricle about this opening 160.
- the prosthesis 136 may also include the various supporting elements described above for supporting the vein segments of the valvular conduit prosthesis 110.
- a plurality of rings may be positioned about the segment 138 in a manner similar to that illustrated and discussed for the conduit prosthesis embodiment of Figures 12 and 13, or a single spiral may be positioned about segment 138 as shown for the embodiment of Figure 14 or a supporting member as shown in the embodiment of Figure 15 may be positioned about the segment 138.
- the valve itself may also be supported as described for the valve of the conduit prosthesis 110.
- a cage similar to cage 124, may be positioned about the valve portion of the prosthesis 136.
- segment 140 is covered with fabric to provide support for the sutures.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2054728A CA2054728C (en) | 1989-05-31 | 1990-05-31 | Biological valvular prosthesis |
EP90909072A EP0474748B1 (en) | 1989-05-31 | 1990-05-31 | Biological valvular prosthesis |
DE69016426T DE69016426T2 (en) | 1989-05-31 | 1990-05-31 | BIOLOGICAL VALVE PROSTHESIS. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35944989A | 1989-05-31 | 1989-05-31 | |
US359,449 | 1989-05-31 | ||
US50082190A | 1990-03-28 | 1990-03-28 | |
US500,821 | 1990-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1990014804A1 true WO1990014804A1 (en) | 1990-12-13 |
Family
ID=27000488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/003053 WO1990014804A1 (en) | 1989-05-31 | 1990-05-31 | Biological valvular prosthesis |
Country Status (7)
Country | Link |
---|---|
US (1) | US5500014A (en) |
EP (1) | EP0474748B1 (en) |
JP (1) | JP3127378B2 (en) |
CA (1) | CA2054728C (en) |
DE (1) | DE69016426T2 (en) |
DK (1) | DK0474748T3 (en) |
WO (1) | WO1990014804A1 (en) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0520126A1 (en) * | 1991-06-25 | 1992-12-30 | Sante Camilli | Artificial venous value |
WO1993004643A1 (en) * | 1991-08-29 | 1993-03-18 | Medtronic, Inc. | Natural tissue heart valve fixation |
WO1993020757A2 (en) * | 1992-04-21 | 1993-10-28 | Baxter International Inc. | Vascular implant system |
US5500014A (en) * | 1989-05-31 | 1996-03-19 | Baxter International Inc. | Biological valvular prothesis |
WO1996019159A1 (en) * | 1994-12-21 | 1996-06-27 | Claude Franceschi | Artificial valve for a blood vessel |
US5545215A (en) * | 1994-09-14 | 1996-08-13 | Duran; Carlos G. | External sigmoid valve complex frame and valved conduit supported by the same |
US5609626A (en) * | 1989-05-31 | 1997-03-11 | Baxter International Inc. | Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts |
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US5810708A (en) * | 1994-02-07 | 1998-09-22 | Baxter International Inc. | Ventricular assist conduit with externally supported tissue valve |
US5824060A (en) * | 1993-09-29 | 1998-10-20 | Medtronic, Inc. | Natural tissue heart valve fixation |
US5830239A (en) * | 1995-11-15 | 1998-11-03 | Medtronic, Inc. | Natural tissue heart valve fixation apparatus and method |
US6001056A (en) * | 1998-11-13 | 1999-12-14 | Baxter International Inc. | Smooth ventricular assist device conduit |
EP1057460A1 (en) * | 1999-06-01 | 2000-12-06 | Numed, Inc. | Replacement valve assembly and method of implanting same |
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US6494904B1 (en) | 1996-12-27 | 2002-12-17 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
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US11406495B2 (en) | 2013-02-11 | 2022-08-09 | Cook Medical Technologies Llc | Expandable support frame and medical device |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
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Families Citing this family (444)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US6273912B1 (en) | 1996-02-28 | 2001-08-14 | Impra, Inc. | Flanged graft for end-to-side anastomosis |
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US6006134A (en) | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
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US5755682A (en) * | 1996-08-13 | 1998-05-26 | Heartstent Corporation | Method and apparatus for performing coronary artery bypass surgery |
JP2001500401A (en) * | 1996-08-26 | 2001-01-16 | トランスバスキュラー インコーポレイテッド | Method and apparatus for transmyocardial direct cardiovascular regeneration |
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NL1004827C2 (en) * | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Device for regulating blood circulation. |
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US5851232A (en) * | 1997-03-15 | 1998-12-22 | Lois; William A. | Venous stent |
WO1998046115A2 (en) * | 1997-04-11 | 1998-10-22 | Transvascular, Inc. | Methods and apparatus for transmyocardial direct coronary revascularization |
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GB9709967D0 (en) * | 1997-05-17 | 1997-07-09 | Harris Peter L | Prosthetic grafts |
US5954766A (en) * | 1997-09-16 | 1999-09-21 | Zadno-Azizi; Gholam-Reza | Body fluid flow control device |
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US6676696B1 (en) | 1998-02-12 | 2004-01-13 | Thomas R. Marotta | Endovascular prosthesis |
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US7452371B2 (en) * | 1999-06-02 | 2008-11-18 | Cook Incorporated | Implantable vascular device |
US6746489B2 (en) | 1998-08-31 | 2004-06-08 | Wilson-Cook Medical Incorporated | Prosthesis having a sleeve valve |
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US7118600B2 (en) * | 1998-08-31 | 2006-10-10 | Wilson-Cook Medical, Inc. | Prosthesis having a sleeve valve |
US20070016306A1 (en) * | 1998-08-31 | 2007-01-18 | Wilson-Cook Medical Inc. | Prosthesis having a sleeve valve |
US20080086214A1 (en) * | 1998-08-31 | 2008-04-10 | Wilson-Cook Medical Inc. | Medical device having a sleeve valve with bioactive agent |
US6254564B1 (en) | 1998-09-10 | 2001-07-03 | Percardia, Inc. | Left ventricular conduit with blood vessel graft |
US6641610B2 (en) | 1998-09-10 | 2003-11-04 | Percardia, Inc. | Valve designs for left ventricular conduits |
US6425916B1 (en) * | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
NO308575B1 (en) | 1999-02-17 | 2000-10-02 | Sumit Roy | multipurpose valve |
US6110201A (en) * | 1999-02-18 | 2000-08-29 | Venpro | Bifurcated biological pulmonary valved conduit |
US6319281B1 (en) | 1999-03-22 | 2001-11-20 | Kumar R. Patel | Artificial venous valve and sizing catheter |
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US6241763B1 (en) | 1999-06-08 | 2001-06-05 | William J. Drasler | In situ venous valve device and method of formation |
US6299637B1 (en) | 1999-08-20 | 2001-10-09 | Samuel M. Shaolian | Transluminally implantable venous valve |
US6315793B1 (en) | 1999-09-08 | 2001-11-13 | Medical Carbon Research Institute, Llc | Prosthetic venous valves |
AU3581000A (en) * | 1999-09-10 | 2001-04-17 | Cook Incorporated | Endovascular treatment for chronic venous insufficiency |
US6440164B1 (en) * | 1999-10-21 | 2002-08-27 | Scimed Life Systems, Inc. | Implantable prosthetic valve |
US8579966B2 (en) | 1999-11-17 | 2013-11-12 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US8016877B2 (en) | 1999-11-17 | 2011-09-13 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US7018406B2 (en) | 1999-11-17 | 2006-03-28 | Corevalve Sa | Prosthetic valve for transluminal delivery |
US20070043435A1 (en) * | 1999-11-17 | 2007-02-22 | Jacques Seguin | Non-cylindrical prosthetic valve system for transluminal delivery |
US6458153B1 (en) * | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US8241274B2 (en) | 2000-01-19 | 2012-08-14 | Medtronic, Inc. | Method for guiding a medical device |
US6692513B2 (en) * | 2000-06-30 | 2004-02-17 | Viacor, Inc. | Intravascular filter with debris entrapment mechanism |
US7749245B2 (en) | 2000-01-27 | 2010-07-06 | Medtronic, Inc. | Cardiac valve procedure methods and devices |
DE60128069D1 (en) * | 2000-01-31 | 2007-06-06 | Cook Biotech Inc | STENT VALVE FLAP |
AU2001238038B2 (en) * | 2000-02-03 | 2005-08-25 | Cook Biotech, Inc. | Implantable vascular device |
US20050267560A1 (en) * | 2000-02-03 | 2005-12-01 | Cook Incorporated | Implantable bioabsorbable valve support frame |
ES2236204T3 (en) * | 2000-03-03 | 2005-07-16 | Cook Incorporated | BULBIFORM AND STENT VALVE FOR THE TREATMENT OF VASCULAR REFLUX. |
US20030070683A1 (en) * | 2000-03-04 | 2003-04-17 | Deem Mark E. | Methods and devices for use in performing pulmonary procedures |
US6679264B1 (en) | 2000-03-04 | 2004-01-20 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US8474460B2 (en) * | 2000-03-04 | 2013-07-02 | Pulmonx Corporation | Implanted bronchial isolation devices and methods |
US6953476B1 (en) * | 2000-03-27 | 2005-10-11 | Neovasc Medical Ltd. | Device and method for treating ischemic heart disease |
IL153753A0 (en) * | 2002-12-30 | 2003-07-06 | Neovasc Medical Ltd | Varying-diameter vascular implant and balloon |
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
US6869444B2 (en) * | 2000-05-22 | 2005-03-22 | Shlomo Gabbay | Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve |
US6973617B1 (en) * | 2000-05-24 | 2005-12-06 | Cisco Technology, Inc. | Apparatus and method for contacting a customer support line on customer's behalf and having a customer support representative contact the customer |
US6695878B2 (en) | 2000-06-26 | 2004-02-24 | Rex Medical, L.P. | Vascular device for valve leaflet apposition |
US6676698B2 (en) * | 2000-06-26 | 2004-01-13 | Rex Medicol, L.P. | Vascular device with valve for approximating vessel wall |
US6527800B1 (en) | 2000-06-26 | 2003-03-04 | Rex Medical, L.P. | Vascular device and method for valve leaflet apposition |
JP2004506469A (en) | 2000-08-18 | 2004-03-04 | アトリテック, インコーポレイテッド | Expandable implantable device for filtering blood flow from the atrial appendage |
US7510572B2 (en) * | 2000-09-12 | 2009-03-31 | Shlomo Gabbay | Implantation system for delivery of a heart valve prosthesis |
US6602286B1 (en) | 2000-10-26 | 2003-08-05 | Ernst Peter Strecker | Implantable valve system |
US8038708B2 (en) * | 2001-02-05 | 2011-10-18 | Cook Medical Technologies Llc | Implantable device with remodelable material and covering material |
US20020112729A1 (en) * | 2001-02-21 | 2002-08-22 | Spiration, Inc. | Intra-bronchial obstructing device that controls biological interaction with the patient |
US7798147B2 (en) * | 2001-03-02 | 2010-09-21 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US6941950B2 (en) * | 2001-10-11 | 2005-09-13 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US20040074491A1 (en) * | 2001-03-02 | 2004-04-22 | Michael Hendricksen | Delivery methods and devices for implantable bronchial isolation devices |
US7011094B2 (en) * | 2001-03-02 | 2006-03-14 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US6503272B2 (en) | 2001-03-21 | 2003-01-07 | Cordis Corporation | Stent-based venous valves |
US7556646B2 (en) | 2001-09-13 | 2009-07-07 | Edwards Lifesciences Corporation | Methods and apparatuses for deploying minimally-invasive heart valves |
US6733525B2 (en) | 2001-03-23 | 2004-05-11 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of use |
US6958076B2 (en) * | 2001-04-16 | 2005-10-25 | Biomedical Research Associates Inc. | Implantable venous valve |
KR100393548B1 (en) | 2001-06-05 | 2003-08-02 | 주식회사 엠아이텍 | Stent |
US7544206B2 (en) * | 2001-06-29 | 2009-06-09 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
FR2826863B1 (en) | 2001-07-04 | 2003-09-26 | Jacques Seguin | ASSEMBLY FOR PLACING A PROSTHETIC VALVE IN A BODY CONDUIT |
US7377938B2 (en) * | 2001-07-19 | 2008-05-27 | The Cleveland Clinic Foundation | Prosthetic cardiac value and method for making same |
FR2828091B1 (en) | 2001-07-31 | 2003-11-21 | Seguin Jacques | ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT |
US7097659B2 (en) | 2001-09-07 | 2006-08-29 | Medtronic, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US20030050648A1 (en) * | 2001-09-11 | 2003-03-13 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US6562069B2 (en) | 2001-09-19 | 2003-05-13 | St. Jude Medical, Inc. | Polymer leaflet designs for medical devices |
JP3673744B2 (en) * | 2001-09-27 | 2005-07-20 | 大晃機械工業株式会社 | Vacuum pump |
JP4398244B2 (en) | 2001-10-04 | 2010-01-13 | ネオヴァスク メディカル リミテッド | Flow reduction implant |
US20060106415A1 (en) * | 2004-11-12 | 2006-05-18 | Shlomo Gabbay | Apparatus to facilitate implantation |
US6893460B2 (en) * | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
US6592594B2 (en) * | 2001-10-25 | 2003-07-15 | Spiration, Inc. | Bronchial obstruction device deployment system and method |
WO2003070124A2 (en) * | 2002-02-20 | 2003-08-28 | Osse Francisco J | Venous bi-valve |
US6929637B2 (en) * | 2002-02-21 | 2005-08-16 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
US20060235432A1 (en) * | 2002-02-21 | 2006-10-19 | Devore Lauri J | Intra-bronchial obstructing device that controls biological interaction with the patient |
US20030154988A1 (en) * | 2002-02-21 | 2003-08-21 | Spiration, Inc. | Intra-bronchial device that provides a medicant intra-bronchially to the patient |
WO2003075796A2 (en) * | 2002-03-08 | 2003-09-18 | Emphasys Medical, Inc. | Methods and devices for inducing collapse in lung regions fed by collateral pathways |
US20030216769A1 (en) * | 2002-05-17 | 2003-11-20 | Dillard David H. | Removable anchored lung volume reduction devices and methods |
US20030181922A1 (en) | 2002-03-20 | 2003-09-25 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US6837903B2 (en) | 2002-03-22 | 2005-01-04 | Clemson University | Vascular biomaterial devices and methods |
US6752828B2 (en) | 2002-04-03 | 2004-06-22 | Scimed Life Systems, Inc. | Artificial valve |
US20030195385A1 (en) * | 2002-04-16 | 2003-10-16 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US8721713B2 (en) * | 2002-04-23 | 2014-05-13 | Medtronic, Inc. | System for implanting a replacement valve |
US7351256B2 (en) * | 2002-05-10 | 2008-04-01 | Cordis Corporation | Frame based unidirectional flow prosthetic implant |
US7270675B2 (en) * | 2002-05-10 | 2007-09-18 | Cordis Corporation | Method of forming a tubular membrane on a structural frame |
AU2003225291A1 (en) * | 2002-05-10 | 2003-11-11 | Cordis Corporation | Method of making a medical device having a thin wall tubular membrane over a structural frame |
US7485141B2 (en) * | 2002-05-10 | 2009-02-03 | Cordis Corporation | Method of placing a tubular membrane on a structural frame |
US7828839B2 (en) * | 2002-05-16 | 2010-11-09 | Cook Incorporated | Flexible barb for anchoring a prosthesis |
US20040117004A1 (en) * | 2002-05-16 | 2004-06-17 | Osborne Thomas A. | Stent and method of forming a stent with integral barbs |
EP1507491A1 (en) * | 2002-05-28 | 2005-02-23 | Emphasys Medical, Inc. | Implantable bronchial isolation devices and lung treatment methods |
US20030229394A1 (en) * | 2002-06-06 | 2003-12-11 | Ogle Matthew F. | Processed tissue for medical device formation |
US20040010209A1 (en) * | 2002-07-15 | 2004-01-15 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
US20040059263A1 (en) * | 2002-09-24 | 2004-03-25 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
ATE407629T1 (en) * | 2002-07-26 | 2008-09-15 | Emphasys Medical Inc | BRONCHIAL FLOW DEVICE WITH A MEMBRANE SEAL |
EP1534180A4 (en) * | 2002-08-08 | 2007-04-04 | Neovasc Medical Ltd | Geometric flow regulator |
US20060106449A1 (en) * | 2002-08-08 | 2006-05-18 | Neovasc Medical Ltd. | Flow reducing implant |
EP1592367B1 (en) | 2002-08-28 | 2016-04-13 | HLT, Inc. | Method and device for treating diseased valve |
WO2004024032A1 (en) * | 2002-09-12 | 2004-03-25 | Cook Incorporated | Retrievable filter |
CO5500017A1 (en) * | 2002-09-23 | 2005-03-31 | 3F Therapeutics Inc | MITRAL PROTESTIC VALVE |
US7814912B2 (en) * | 2002-11-27 | 2010-10-19 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
WO2004049974A2 (en) * | 2002-11-27 | 2004-06-17 | Emphasys Medical, Inc. | Delivery method and device for implantable bronchial isolation devices |
US7766973B2 (en) * | 2005-01-19 | 2010-08-03 | Gi Dynamics, Inc. | Eversion resistant sleeves |
US20070032879A1 (en) * | 2002-12-02 | 2007-02-08 | Levine Andy H | Anti-buckling sleeve |
US6945957B2 (en) | 2002-12-30 | 2005-09-20 | Scimed Life Systems, Inc. | Valve treatment catheter and methods |
TW200501913A (en) * | 2003-01-15 | 2005-01-16 | Univ Miami | Venous anti-reflux implant |
US7399315B2 (en) | 2003-03-18 | 2008-07-15 | Edwards Lifescience Corporation | Minimally-invasive heart valve with cusp positioners |
US7100616B2 (en) * | 2003-04-08 | 2006-09-05 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
US7374488B2 (en) * | 2003-04-17 | 2008-05-20 | Atronic Systems G.M.B.H. | Player insert for a gaming machine, a gaming system and a method of operating a gaming system |
JP4940388B2 (en) * | 2003-04-24 | 2012-05-30 | クック メディカル テクノロジーズ エルエルシー | Prosthetic valve prosthesis with improved hydrodynamic properties |
US7717952B2 (en) * | 2003-04-24 | 2010-05-18 | Cook Incorporated | Artificial prostheses with preferred geometries |
US7200559B2 (en) * | 2003-05-29 | 2007-04-03 | Microsoft Corporation | Semantic object synchronous understanding implemented with speech application language tags |
US7533671B2 (en) | 2003-08-08 | 2009-05-19 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US7160322B2 (en) * | 2003-08-13 | 2007-01-09 | Shlomo Gabbay | Implantable cardiac prosthesis for mitigating prolapse of a heart valve |
US20050075725A1 (en) | 2003-10-02 | 2005-04-07 | Rowe Stanton J. | Implantable prosthetic valve with non-laminar flow |
US20050075729A1 (en) * | 2003-10-06 | 2005-04-07 | Nguyen Tuoc Tan | Minimally invasive valve replacement system |
US20060259137A1 (en) * | 2003-10-06 | 2006-11-16 | Jason Artof | Minimally invasive valve replacement system |
US9579194B2 (en) | 2003-10-06 | 2017-02-28 | Medtronic ATS Medical, Inc. | Anchoring structure with concave landing zone |
JP5131796B2 (en) * | 2003-10-24 | 2013-01-30 | 株式会社サンメディカル技術研究所 | Artificial blood vessel system, connection aid and blood pump system |
US7070616B2 (en) * | 2003-10-31 | 2006-07-04 | Cordis Corporation | Implantable valvular prosthesis |
US7347869B2 (en) * | 2003-10-31 | 2008-03-25 | Cordis Corporation | Implantable valvular prosthesis |
US7854761B2 (en) * | 2003-12-19 | 2010-12-21 | Boston Scientific Scimed, Inc. | Methods for venous valve replacement with a catheter |
US8828078B2 (en) | 2003-12-23 | 2014-09-09 | Sadra Medical, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US9005273B2 (en) | 2003-12-23 | 2015-04-14 | Sadra Medical, Inc. | Assessing the location and performance of replacement heart valves |
CN101947146B (en) | 2003-12-23 | 2014-08-06 | 萨德拉医学公司 | Relocatable heart valve |
US20120041550A1 (en) | 2003-12-23 | 2012-02-16 | Sadra Medical, Inc. | Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements |
US7445631B2 (en) | 2003-12-23 | 2008-11-04 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US8840663B2 (en) | 2003-12-23 | 2014-09-23 | Sadra Medical, Inc. | Repositionable heart valve method |
US7959666B2 (en) | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
US8343213B2 (en) | 2003-12-23 | 2013-01-01 | Sadra Medical, Inc. | Leaflet engagement elements and methods for use thereof |
US7780725B2 (en) | 2004-06-16 | 2010-08-24 | Sadra Medical, Inc. | Everting heart valve |
US8603160B2 (en) | 2003-12-23 | 2013-12-10 | Sadra Medical, Inc. | Method of using a retrievable heart valve anchor with a sheath |
US7381219B2 (en) | 2003-12-23 | 2008-06-03 | Sadra Medical, Inc. | Low profile heart valve and delivery system |
US8182528B2 (en) | 2003-12-23 | 2012-05-22 | Sadra Medical, Inc. | Locking heart valve anchor |
US7329279B2 (en) | 2003-12-23 | 2008-02-12 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US20050137687A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical | Heart valve anchor and method |
US11278398B2 (en) | 2003-12-23 | 2022-03-22 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US8579962B2 (en) | 2003-12-23 | 2013-11-12 | Sadra Medical, Inc. | Methods and apparatus for performing valvuloplasty |
US20050137694A1 (en) | 2003-12-23 | 2005-06-23 | Haug Ulrich R. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US9526609B2 (en) | 2003-12-23 | 2016-12-27 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
WO2005070342A1 (en) * | 2004-01-22 | 2005-08-04 | Australian Surgical Design & Manufacture Pty Ltd | Heart valve |
US20050178389A1 (en) * | 2004-01-27 | 2005-08-18 | Shaw David P. | Disease indications for selective endobronchial lung region isolation |
US8337545B2 (en) | 2004-02-09 | 2012-12-25 | Cook Medical Technologies Llc | Woven implantable device |
US8206684B2 (en) * | 2004-02-27 | 2012-06-26 | Pulmonx Corporation | Methods and devices for blocking flow through collateral pathways in the lung |
ITTO20040135A1 (en) * | 2004-03-03 | 2004-06-03 | Sorin Biomedica Cardio Spa | CARDIAC VALVE PROSTHESIS |
EP2368525B1 (en) * | 2004-03-08 | 2019-09-18 | Pulmonx, Inc | Implanted bronchial isolation devices |
US7510561B2 (en) * | 2004-03-23 | 2009-03-31 | Correx, Inc. | Apparatus and method for connecting a conduit to a hollow organ |
US7799041B2 (en) * | 2004-03-23 | 2010-09-21 | Correx, Inc. | Apparatus and method for forming a hole in a hollow organ |
WO2005096988A1 (en) | 2004-04-01 | 2005-10-20 | Cook Incorporated | A device for retracting the walls of a body vessel with remodelable material |
EP1737390A1 (en) * | 2004-04-08 | 2007-01-03 | Cook Incorporated | Implantable medical device with optimized shape |
US20060025857A1 (en) | 2004-04-23 | 2006-02-02 | Bjarne Bergheim | Implantable prosthetic valve |
US7641686B2 (en) * | 2004-04-23 | 2010-01-05 | Direct Flow Medical, Inc. | Percutaneous heart valve with stentless support |
US8012201B2 (en) | 2004-05-05 | 2011-09-06 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with multiple chamber formed in place support |
US20060122693A1 (en) * | 2004-05-10 | 2006-06-08 | Youssef Biadillah | Stent valve and method of manufacturing same |
US20060030863A1 (en) * | 2004-07-21 | 2006-02-09 | Fields Antony J | Implanted bronchial isolation device delivery devices and methods |
US7566343B2 (en) | 2004-09-02 | 2009-07-28 | Boston Scientific Scimed, Inc. | Cardiac valve, system, and method |
US20060052867A1 (en) | 2004-09-07 | 2006-03-09 | Medtronic, Inc | Replacement prosthetic heart valve, system and method of implant |
US20060167468A1 (en) * | 2004-11-12 | 2006-07-27 | Shlomo Gabbay | Implantation system and method for loading an implanter with a prosthesis |
US8562672B2 (en) | 2004-11-19 | 2013-10-22 | Medtronic, Inc. | Apparatus for treatment of cardiac valves and method of its manufacture |
US7744642B2 (en) * | 2004-11-19 | 2010-06-29 | Biomedical Research Associates, Inc. | Prosthetic venous valves |
US7771472B2 (en) * | 2004-11-19 | 2010-08-10 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
WO2006065966A2 (en) * | 2004-12-15 | 2006-06-22 | Correx, Inc. | Apparatus and method for connecting a conduit to a hollow vessel |
US20060173490A1 (en) | 2005-02-01 | 2006-08-03 | Boston Scientific Scimed, Inc. | Filter system and method |
US7854755B2 (en) | 2005-02-01 | 2010-12-21 | Boston Scientific Scimed, Inc. | Vascular catheter, system, and method |
US7878966B2 (en) * | 2005-02-04 | 2011-02-01 | Boston Scientific Scimed, Inc. | Ventricular assist and support device |
US7670368B2 (en) | 2005-02-07 | 2010-03-02 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7780722B2 (en) * | 2005-02-07 | 2010-08-24 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
JP4740619B2 (en) * | 2005-02-17 | 2011-08-03 | サンゴ エッセ.ア.エッセ. ディ カッターニ リータ エ チ. | External support for venous valves to restore capacity by traction of their commissural walls |
US7867274B2 (en) | 2005-02-23 | 2011-01-11 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US8876791B2 (en) | 2005-02-25 | 2014-11-04 | Pulmonx Corporation | Collateral pathway treatment using agent entrained by aspiration flow current |
US7331991B2 (en) | 2005-02-25 | 2008-02-19 | California Institute Of Technology | Implantable small percutaneous valve and methods of delivery |
US8197534B2 (en) * | 2005-03-31 | 2012-06-12 | Cook Medical Technologies Llc | Valve device with inflatable chamber |
US7722666B2 (en) | 2005-04-15 | 2010-05-25 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US7962208B2 (en) | 2005-04-25 | 2011-06-14 | Cardiac Pacemakers, Inc. | Method and apparatus for pacing during revascularization |
US7914569B2 (en) | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
US9955969B2 (en) * | 2005-05-26 | 2018-05-01 | Texas Heart Institute | Surgical system and method for attaching a prosthetic vessel to a hollow structure |
US8568477B2 (en) * | 2005-06-07 | 2013-10-29 | Direct Flow Medical, Inc. | Stentless aortic valve replacement with high radial strength |
US8012198B2 (en) | 2005-06-10 | 2011-09-06 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US7780723B2 (en) | 2005-06-13 | 2010-08-24 | Edwards Lifesciences Corporation | Heart valve delivery system |
US8709069B2 (en) | 2005-07-01 | 2014-04-29 | C. R. Bard, Inc. | Flanged graft with trim lines |
US20080269879A1 (en) * | 2005-07-27 | 2008-10-30 | Rahul Dilip Sathe | Implantable Prosthetic Vascular Valve |
US20070027460A1 (en) * | 2005-07-27 | 2007-02-01 | Cook Incorporated | Implantable remodelable materials comprising magnetic material |
WO2007016251A2 (en) * | 2005-07-28 | 2007-02-08 | Cook Incorporated | Implantable thromboresistant valve |
US20070027528A1 (en) * | 2005-07-29 | 2007-02-01 | Cook Incorporated | Elliptical implantable device |
US20070050013A1 (en) * | 2005-09-01 | 2007-03-01 | Jeffrey M. Gross | Venous valve prosthesis and method of fabrication |
US20070067029A1 (en) * | 2005-09-16 | 2007-03-22 | Shlomo Gabbay | Support apparatus to facilitate implantation of cardiac prosthesis |
US7569071B2 (en) | 2005-09-21 | 2009-08-04 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US20070078510A1 (en) | 2005-09-26 | 2007-04-05 | Ryan Timothy R | Prosthetic cardiac and venous valves |
US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US9078781B2 (en) * | 2006-01-11 | 2015-07-14 | Medtronic, Inc. | Sterile cover for compressible stents used in percutaneous device delivery systems |
US7799038B2 (en) | 2006-01-20 | 2010-09-21 | Boston Scientific Scimed, Inc. | Translumenal apparatus, system, and method |
CN101415379B (en) | 2006-02-14 | 2012-06-20 | 萨德拉医学公司 | Systems for delivering a medical implant |
US7780724B2 (en) * | 2006-02-24 | 2010-08-24 | California Institute Of Technology | Monolithic in situ forming valve system |
US20080275550A1 (en) * | 2006-02-24 | 2008-11-06 | Arash Kheradvar | Implantable small percutaneous valve and methods of delivery |
WO2007123658A1 (en) | 2006-03-28 | 2007-11-01 | Medtronic, Inc. | Prosthetic cardiac valve formed from pericardium material and methods of making same |
US7691151B2 (en) * | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
US7829986B2 (en) * | 2006-04-01 | 2010-11-09 | Stats Chippac Ltd. | Integrated circuit package system with net spacer |
US7740655B2 (en) * | 2006-04-06 | 2010-06-22 | Medtronic Vascular, Inc. | Reinforced surgical conduit for implantation of a stented valve therein |
WO2007117612A1 (en) * | 2006-04-06 | 2007-10-18 | Correx, Inc. | Apparatus and method for suturelessly connecting a conduit to a hollow organ |
US20070239254A1 (en) * | 2006-04-07 | 2007-10-11 | Chris Chia | System for percutaneous delivery and removal of a prosthetic valve |
US20070239271A1 (en) * | 2006-04-10 | 2007-10-11 | Than Nguyen | Systems and methods for loading a prosthesis onto a minimally invasive delivery system |
DE602007007602D1 (en) * | 2006-05-25 | 2010-08-19 | Deep Vein Medical Inc | DEVICE FOR BLOOD FLOW REGULATION |
US7811316B2 (en) * | 2006-05-25 | 2010-10-12 | Deep Vein Medical, Inc. | Device for regulating blood flow |
US8092517B2 (en) * | 2006-05-25 | 2012-01-10 | Deep Vein Medical, Inc. | Device for regulating blood flow |
US9408607B2 (en) | 2009-07-02 | 2016-08-09 | Edwards Lifesciences Cardiaq Llc | Surgical implant devices and methods for their manufacture and use |
WO2008016578A2 (en) | 2006-07-31 | 2008-02-07 | Cartledge Richard G | Sealable endovascular implants and methods for their use |
US9585743B2 (en) | 2006-07-31 | 2017-03-07 | Edwards Lifesciences Cardiaq Llc | Surgical implant devices and methods for their manufacture and use |
US8257429B2 (en) * | 2006-08-21 | 2012-09-04 | Oregon Health & Science University | Biomedical valve devices, support frames for use in such devices, and related methods |
US20080072914A1 (en) * | 2006-08-25 | 2008-03-27 | Hendricksen Michael J | Bronchial Isolation Devices for Placement in Short Lumens |
US11304800B2 (en) | 2006-09-19 | 2022-04-19 | Medtronic Ventor Technologies Ltd. | Sinus-engaging valve fixation member |
US8876894B2 (en) | 2006-09-19 | 2014-11-04 | Medtronic Ventor Technologies Ltd. | Leaflet-sensitive valve fixation member |
US8834564B2 (en) | 2006-09-19 | 2014-09-16 | Medtronic, Inc. | Sinus-engaging valve fixation member |
WO2008047354A2 (en) | 2006-10-16 | 2008-04-24 | Ventor Technologies Ltd. | Transapical delivery system with ventriculo-arterial overflow bypass |
US7935144B2 (en) | 2006-10-19 | 2011-05-03 | Direct Flow Medical, Inc. | Profile reduction of valve implant |
US8133213B2 (en) * | 2006-10-19 | 2012-03-13 | Direct Flow Medical, Inc. | Catheter guidance through a calcified aortic valve |
JP5593545B2 (en) | 2006-12-06 | 2014-09-24 | メドトロニック シーブイ ルクセンブルク エス.アー.エール.エル. | System and method for transapical delivery of a self-expanding valve secured to an annulus |
US8236045B2 (en) * | 2006-12-22 | 2012-08-07 | Edwards Lifesciences Corporation | Implantable prosthetic valve assembly and method of making the same |
WO2008091493A1 (en) | 2007-01-08 | 2008-07-31 | California Institute Of Technology | In-situ formation of a valve |
US8303649B2 (en) * | 2007-01-29 | 2012-11-06 | Cook Medical Technologies Llc | Artificial venous valve with discrete shaping members |
US9415567B2 (en) * | 2007-02-05 | 2016-08-16 | Boston Scientific Scimed, Inc. | Synthetic composite structures |
WO2008097589A1 (en) | 2007-02-05 | 2008-08-14 | Boston Scientific Limited | Percutaneous valve, system, and method |
WO2008103280A2 (en) | 2007-02-16 | 2008-08-28 | Medtronic, Inc. | Delivery systems and methods of implantation for replacement prosthetic heart valves |
US8221505B2 (en) * | 2007-02-22 | 2012-07-17 | Cook Medical Technologies Llc | Prosthesis having a sleeve valve |
FR2915087B1 (en) | 2007-04-20 | 2021-11-26 | Corevalve Inc | IMPLANT FOR TREATMENT OF A HEART VALVE, IN PARTICULAR OF A MITRAL VALVE, EQUIPMENT INCLUDING THIS IMPLANT AND MATERIAL FOR PLACING THIS IMPLANT. |
US8828079B2 (en) | 2007-07-26 | 2014-09-09 | Boston Scientific Scimed, Inc. | Circulatory valve, system and method |
US9566178B2 (en) | 2010-06-24 | 2017-02-14 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
US8747458B2 (en) | 2007-08-20 | 2014-06-10 | Medtronic Ventor Technologies Ltd. | Stent loading tool and method for use thereof |
US8100820B2 (en) * | 2007-08-22 | 2012-01-24 | Edwards Lifesciences Corporation | Implantable device for treatment of ventricular dilation |
US20090088836A1 (en) | 2007-08-23 | 2009-04-02 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with formed in place support |
US8834551B2 (en) * | 2007-08-31 | 2014-09-16 | Rex Medical, L.P. | Vascular device with valve for approximating vessel wall |
DE102007043830A1 (en) | 2007-09-13 | 2009-04-02 | Lozonschi, Lucian, Madison | Heart valve stent |
CA2700849C (en) * | 2007-09-25 | 2016-07-26 | Correx, Inc. | Applicator, assembly, and method for connecting an inlet conduit to a hollow organ |
JP5628673B2 (en) | 2007-09-26 | 2014-11-19 | セント ジュード メディカル インコーポレイテッド | Foldable prosthetic heart valve |
US9532868B2 (en) | 2007-09-28 | 2017-01-03 | St. Jude Medical, Inc. | Collapsible-expandable prosthetic heart valves with structures for clamping native tissue |
US10856970B2 (en) | 2007-10-10 | 2020-12-08 | Medtronic Ventor Technologies Ltd. | Prosthetic heart valve for transfemoral delivery |
US20090138079A1 (en) * | 2007-10-10 | 2009-05-28 | Vector Technologies Ltd. | Prosthetic heart valve for transfemoral delivery |
US8043301B2 (en) * | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
JP5570993B2 (en) * | 2007-10-12 | 2014-08-13 | スピレーション インコーポレイテッド | Valve loader methods, systems, and apparatus |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
US20090105813A1 (en) * | 2007-10-17 | 2009-04-23 | Sean Chambers | Implantable valve device |
US7846199B2 (en) * | 2007-11-19 | 2010-12-07 | Cook Incorporated | Remodelable prosthetic valve |
ES2887787T3 (en) | 2007-12-14 | 2021-12-27 | Edwards Lifesciences Corp | Leaflet Attachment Frame for a Prosthetic Valve |
US8876897B2 (en) * | 2007-12-20 | 2014-11-04 | Arash Kheradvar | Implantable prosthetic valves and methods relating to same |
US7892276B2 (en) | 2007-12-21 | 2011-02-22 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
US20100280598A1 (en) * | 2007-12-27 | 2010-11-04 | C.R. Bard, Inc. | Vascular graft prosthesis having a reinforced margin for enhanced anastomosis |
US9149358B2 (en) | 2008-01-24 | 2015-10-06 | Medtronic, Inc. | Delivery systems for prosthetic heart valves |
US9393115B2 (en) | 2008-01-24 | 2016-07-19 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
EP2254512B1 (en) * | 2008-01-24 | 2016-01-06 | Medtronic, Inc. | Markers for prosthetic heart valves |
US7972378B2 (en) | 2008-01-24 | 2011-07-05 | Medtronic, Inc. | Stents for prosthetic heart valves |
US8628566B2 (en) | 2008-01-24 | 2014-01-14 | Medtronic, Inc. | Stents for prosthetic heart valves |
US8157852B2 (en) | 2008-01-24 | 2012-04-17 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
EP3915525A1 (en) | 2008-02-28 | 2021-12-01 | Medtronic, Inc. | Prosthetic heart valve systems |
ES2400494T3 (en) | 2008-02-29 | 2013-04-10 | Edwards Lifesciences Corporation | Expandable element to deploy a prosthetic device |
US9241792B2 (en) | 2008-02-29 | 2016-01-26 | Edwards Lifesciences Corporation | Two-step heart valve implantation |
US8696689B2 (en) * | 2008-03-18 | 2014-04-15 | Medtronic Ventor Technologies Ltd. | Medical suturing device and method for use thereof |
US8313525B2 (en) | 2008-03-18 | 2012-11-20 | Medtronic Ventor Technologies, Ltd. | Valve suturing and implantation procedures |
US8430927B2 (en) | 2008-04-08 | 2013-04-30 | Medtronic, Inc. | Multiple orifice implantable heart valve and methods of implantation |
US8696743B2 (en) | 2008-04-23 | 2014-04-15 | Medtronic, Inc. | Tissue attachment devices and methods for prosthetic heart valves |
US8312825B2 (en) | 2008-04-23 | 2012-11-20 | Medtronic, Inc. | Methods and apparatuses for assembly of a pericardial prosthetic heart valve |
US20090276040A1 (en) | 2008-05-01 | 2009-11-05 | Edwards Lifesciences Corporation | Device and method for replacing mitral valve |
US9061119B2 (en) * | 2008-05-09 | 2015-06-23 | Edwards Lifesciences Corporation | Low profile delivery system for transcatheter heart valve |
PT3263070T (en) | 2008-06-06 | 2020-01-07 | Edwards Lifesciences Corp | Low profile transcatheter heart valve |
US8323335B2 (en) * | 2008-06-20 | 2012-12-04 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic valves and methods for using |
EP3025681B1 (en) | 2008-07-15 | 2017-02-01 | St. Jude Medical, Inc. | Collabsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications |
US8652202B2 (en) | 2008-08-22 | 2014-02-18 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
WO2010031060A1 (en) | 2008-09-15 | 2010-03-18 | Medtronic Ventor Technologies Ltd. | Prosthetic heart valve having identifiers for aiding in radiographic positioning |
US8721714B2 (en) | 2008-09-17 | 2014-05-13 | Medtronic Corevalve Llc | Delivery system for deployment of medical devices |
JP5607639B2 (en) | 2008-10-10 | 2014-10-15 | サドラ メディカル インコーポレイテッド | Medical devices and systems |
US8790387B2 (en) | 2008-10-10 | 2014-07-29 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
US8690936B2 (en) | 2008-10-10 | 2014-04-08 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
US8137398B2 (en) * | 2008-10-13 | 2012-03-20 | Medtronic Ventor Technologies Ltd | Prosthetic valve having tapered tip when compressed for delivery |
US8986361B2 (en) | 2008-10-17 | 2015-03-24 | Medtronic Corevalve, Inc. | Delivery system for deployment of medical devices |
WO2010080884A1 (en) * | 2009-01-07 | 2010-07-15 | Cook Incorporated | Implantable valve prosthesis with independent frame elements |
US20100217382A1 (en) * | 2009-02-25 | 2010-08-26 | Edwards Lifesciences | Mitral valve replacement with atrial anchoring |
US8449599B2 (en) | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
EP2509538B1 (en) | 2009-12-08 | 2017-09-20 | Avalon Medical Ltd. | Device and system for transcatheter mitral valve replacement |
US9226826B2 (en) | 2010-02-24 | 2016-01-05 | Medtronic, Inc. | Transcatheter valve structure and methods for valve delivery |
US8795354B2 (en) * | 2010-03-05 | 2014-08-05 | Edwards Lifesciences Corporation | Low-profile heart valve and delivery system |
US8652204B2 (en) | 2010-04-01 | 2014-02-18 | Medtronic, Inc. | Transcatheter valve with torsion spring fixation and related systems and methods |
US9603708B2 (en) | 2010-05-19 | 2017-03-28 | Dfm, Llc | Low crossing profile delivery catheter for cardiovascular prosthetic implant |
AU2011275468B2 (en) | 2010-07-09 | 2014-02-06 | Highlife Sas | Transcatheter atrio-ventricular valve prosthesis |
EP2595569A4 (en) | 2010-07-23 | 2016-02-24 | Edwards Lifesciences Corp | Retaining mechanisms for prosthetic valves |
CN103140257A (en) * | 2010-07-23 | 2013-06-05 | 梅德拉控股公司 | Enteral feeding connector and assembly |
US20120130468A1 (en) | 2010-07-27 | 2012-05-24 | Fred Khosravi | Methods and apparatus for treating neurovascular venous outflow obstruction |
EP2611388B1 (en) | 2010-09-01 | 2022-04-27 | Medtronic Vascular Galway | Prosthetic valve support structure |
CA2808673C (en) | 2010-09-10 | 2019-07-02 | Symetis Sa | Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device |
PT3626208T (en) | 2010-10-05 | 2021-04-22 | Edwards Lifesciences Corp | Prosthetic heart valve |
CN105380730B (en) | 2010-10-05 | 2018-08-17 | 爱德华兹生命科学公司 | Heart valve prosthesis |
US9005279B2 (en) | 2010-11-12 | 2015-04-14 | Shlomo Gabbay | Beating heart buttress and implantation method to prevent prolapse of a heart valve |
GB2488530A (en) * | 2011-02-18 | 2012-09-05 | David J Wheatley | Heart valve |
US9155619B2 (en) | 2011-02-25 | 2015-10-13 | Edwards Lifesciences Corporation | Prosthetic heart valve delivery apparatus |
EP2520251A1 (en) | 2011-05-05 | 2012-11-07 | Symetis SA | Method and Apparatus for Compressing Stent-Valves |
US8795241B2 (en) | 2011-05-13 | 2014-08-05 | Spiration, Inc. | Deployment catheter |
US9289282B2 (en) | 2011-05-31 | 2016-03-22 | Edwards Lifesciences Corporation | System and method for treating valve insufficiency or vessel dilatation |
WO2013009975A1 (en) | 2011-07-12 | 2013-01-17 | Boston Scientific Scimed, Inc. | Coupling system for medical devices |
US8795357B2 (en) | 2011-07-15 | 2014-08-05 | Edwards Lifesciences Corporation | Perivalvular sealing for transcatheter heart valve |
US9119716B2 (en) | 2011-07-27 | 2015-09-01 | Edwards Lifesciences Corporation | Delivery systems for prosthetic heart valve |
US9668859B2 (en) | 2011-08-05 | 2017-06-06 | California Institute Of Technology | Percutaneous heart valve delivery systems |
CA2957442C (en) | 2011-08-11 | 2019-06-04 | Tendyne Holdings, Inc. | Improvements for prosthetic valves and related inventions |
EP2758010B1 (en) | 2011-09-23 | 2017-02-08 | Pulmonx, Inc | Implant loading system |
US9827093B2 (en) | 2011-10-21 | 2017-11-28 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
US8951243B2 (en) | 2011-12-03 | 2015-02-10 | Boston Scientific Scimed, Inc. | Medical device handle |
EP4049626A1 (en) | 2011-12-09 | 2022-08-31 | Edwards Lifesciences Corporation | Prosthetic heart valve having improved commissure supports |
US9827092B2 (en) | 2011-12-16 | 2017-11-28 | Tendyne Holdings, Inc. | Tethers for prosthetic mitral valve |
US10172708B2 (en) | 2012-01-25 | 2019-01-08 | Boston Scientific Scimed, Inc. | Valve assembly with a bioabsorbable gasket and a replaceable valve implant |
EP3424469A1 (en) | 2012-02-22 | 2019-01-09 | Syntheon TAVR, LLC | Actively controllable stent, stent graft and heart valve |
US9168122B2 (en) | 2012-04-26 | 2015-10-27 | Rex Medical, L.P. | Vascular device and method for valve leaflet apposition |
US9445897B2 (en) | 2012-05-01 | 2016-09-20 | Direct Flow Medical, Inc. | Prosthetic implant delivery device with introducer catheter |
US9883941B2 (en) | 2012-06-19 | 2018-02-06 | Boston Scientific Scimed, Inc. | Replacement heart valve |
WO2014022124A1 (en) | 2012-07-28 | 2014-02-06 | Tendyne Holdings, Inc. | Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly |
WO2014021905A1 (en) | 2012-07-30 | 2014-02-06 | Tendyne Holdings, Inc. | Improved delivery systems and methods for transcatheter prosthetic valves |
US20140067048A1 (en) | 2012-09-06 | 2014-03-06 | Edwards Lifesciences Corporation | Heart Valve Sealing Devices |
WO2014045426A1 (en) * | 2012-09-24 | 2014-03-27 | テルモ株式会社 | Indwelling device and indwelling device assembled body |
WO2014081796A1 (en) | 2012-11-21 | 2014-05-30 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic heart valves |
US8978693B2 (en) | 2013-01-28 | 2015-03-17 | Windcatcher Technology LLC | Inflation valve allowing for rapid inflation and deflation of an inflatable object |
US9439763B2 (en) | 2013-02-04 | 2016-09-13 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US9168129B2 (en) | 2013-02-12 | 2015-10-27 | Edwards Lifesciences Corporation | Artificial heart valve with scalloped frame design |
WO2014144247A1 (en) | 2013-03-15 | 2014-09-18 | Arash Kheradvar | Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves |
US9486306B2 (en) | 2013-04-02 | 2016-11-08 | Tendyne Holdings, Inc. | Inflatable annular sealing device for prosthetic mitral valve |
US10463489B2 (en) | 2013-04-02 | 2019-11-05 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US11224510B2 (en) | 2013-04-02 | 2022-01-18 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US10478293B2 (en) | 2013-04-04 | 2019-11-19 | Tendyne Holdings, Inc. | Retrieval and repositioning system for prosthetic heart valve |
EP2991586A1 (en) | 2013-05-03 | 2016-03-09 | Medtronic Inc. | Valve delivery tool |
TR201816620T4 (en) | 2013-05-20 | 2018-11-21 | Edwards Lifesciences Corp | Heart valve prosthesis delivery device. |
US9610159B2 (en) | 2013-05-30 | 2017-04-04 | Tendyne Holdings, Inc. | Structural members for prosthetic mitral valves |
CN108814772B (en) | 2013-06-25 | 2020-09-08 | 坦迪尼控股股份有限公司 | Thrombus management and structural compliance features for prosthetic heart valves |
AU2014296087B2 (en) | 2013-08-01 | 2019-08-01 | Tendyne Holdings, Inc. | Epicardial anchor devices and methods |
WO2015023579A1 (en) | 2013-08-12 | 2015-02-19 | Mitral Valve Technologies Sa | Apparatus and methods for implanting a replacement heart valve |
WO2015058039A1 (en) | 2013-10-17 | 2015-04-23 | Robert Vidlund | Apparatus and methods for alignment and deployment of intracardiac devices |
EP3656353A1 (en) | 2013-10-28 | 2020-05-27 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems for delivering the same |
US9526611B2 (en) | 2013-10-29 | 2016-12-27 | Tendyne Holdings, Inc. | Apparatus and methods for delivery of transcatheter prosthetic valves |
US9913715B2 (en) | 2013-11-06 | 2018-03-13 | St. Jude Medical, Cardiology Division, Inc. | Paravalvular leak sealing mechanism |
CA2934975A1 (en) | 2013-11-11 | 2015-05-14 | Edwards Lifesciences Cardiaq Llc | Systems and methods for manufacturing a stent frame |
US9622863B2 (en) | 2013-11-22 | 2017-04-18 | Edwards Lifesciences Corporation | Aortic insufficiency repair device and method |
US10098734B2 (en) | 2013-12-05 | 2018-10-16 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
WO2015120122A2 (en) | 2014-02-05 | 2015-08-13 | Robert Vidlund | Apparatus and methods for transfemoral delivery of prosthetic mitral valve |
US9986993B2 (en) | 2014-02-11 | 2018-06-05 | Tendyne Holdings, Inc. | Adjustable tether and epicardial pad system for prosthetic heart valve |
CN106068109B (en) | 2014-03-10 | 2019-07-23 | 坦迪尼控股股份有限公司 | Device and method for positioning and monitoring the tether load of prosthetic mitral valve |
US9668861B2 (en) | 2014-03-15 | 2017-06-06 | Rex Medical, L.P. | Vascular device for treating venous valve insufficiency |
US10583003B2 (en) | 2014-05-06 | 2020-03-10 | Dsm Ip Assets B.V. | Method of making a prosthetic valve and valve obtained therewith |
WO2015169868A1 (en) | 2014-05-06 | 2015-11-12 | Dsm Ip Assets B.V. | Method of making a prosthetic valve and valve obtained therewith |
EP3139863B1 (en) * | 2014-05-06 | 2020-01-22 | DSM IP Assets B.V. | Prosthetic valve and method for making same |
EA033440B1 (en) | 2014-05-06 | 2019-10-31 | Dsm Ip Assets Bv | Prosthetic valve and method of making same |
US9532870B2 (en) | 2014-06-06 | 2017-01-03 | Edwards Lifesciences Corporation | Prosthetic valve for replacing a mitral valve |
US10195026B2 (en) | 2014-07-22 | 2019-02-05 | Edwards Lifesciences Corporation | Mitral valve anchoring |
US10058424B2 (en) | 2014-08-21 | 2018-08-28 | Edwards Lifesciences Corporation | Dual-flange prosthetic valve frame |
US10016272B2 (en) | 2014-09-12 | 2018-07-10 | Mitral Valve Technologies Sarl | Mitral repair and replacement devices and methods |
US9901445B2 (en) | 2014-11-21 | 2018-02-27 | Boston Scientific Scimed, Inc. | Valve locking mechanism |
JP6826035B2 (en) | 2015-01-07 | 2021-02-03 | テンダイン ホールディングス,インコーポレイテッド | Artificial mitral valve, and devices and methods for its delivery |
WO2016115375A1 (en) | 2015-01-16 | 2016-07-21 | Boston Scientific Scimed, Inc. | Displacement based lock and release mechanism |
US9861477B2 (en) | 2015-01-26 | 2018-01-09 | Boston Scientific Scimed Inc. | Prosthetic heart valve square leaflet-leaflet stitch |
US9788942B2 (en) | 2015-02-03 | 2017-10-17 | Boston Scientific Scimed Inc. | Prosthetic heart valve having tubular seal |
WO2016126524A1 (en) | 2015-02-03 | 2016-08-11 | Boston Scientific Scimed, Inc. | Prosthetic heart valve having tubular seal |
CN107896484B (en) | 2015-02-05 | 2020-09-08 | 坦迪尼控股股份有限公司 | Expandable epicardial pad and delivery devices and methods therefor |
US10201425B2 (en) * | 2015-03-02 | 2019-02-12 | Georgia Tech Research Corporation | Implantable open vein valve |
US10426617B2 (en) | 2015-03-06 | 2019-10-01 | Boston Scientific Scimed, Inc. | Low profile valve locking mechanism and commissure assembly |
US10285809B2 (en) | 2015-03-06 | 2019-05-14 | Boston Scientific Scimed Inc. | TAVI anchoring assist device |
US10080652B2 (en) | 2015-03-13 | 2018-09-25 | Boston Scientific Scimed, Inc. | Prosthetic heart valve having an improved tubular seal |
US10327896B2 (en) | 2015-04-10 | 2019-06-25 | Edwards Lifesciences Corporation | Expandable sheath with elastomeric cross sectional portions |
US10792471B2 (en) | 2015-04-10 | 2020-10-06 | Edwards Lifesciences Corporation | Expandable sheath |
JP6694948B2 (en) | 2015-04-16 | 2020-05-20 | テンダイン ホールディングス,インコーポレイテッド | Device and method for delivery, repositioning and retrieval of a transcatheter prosthetic valve |
US10064718B2 (en) | 2015-04-16 | 2018-09-04 | Edwards Lifesciences Corporation | Low-profile prosthetic heart valve for replacing a mitral valve |
US10010417B2 (en) | 2015-04-16 | 2018-07-03 | Edwards Lifesciences Corporation | Low-profile prosthetic heart valve for replacing a mitral valve |
US10195392B2 (en) | 2015-07-02 | 2019-02-05 | Boston Scientific Scimed, Inc. | Clip-on catheter |
WO2017004377A1 (en) | 2015-07-02 | 2017-01-05 | Boston Scientific Scimed, Inc. | Adjustable nosecone |
US10179041B2 (en) | 2015-08-12 | 2019-01-15 | Boston Scientific Scimed Icn. | Pinless release mechanism |
US10136991B2 (en) | 2015-08-12 | 2018-11-27 | Boston Scientific Scimed Inc. | Replacement heart valve implant |
US10327894B2 (en) | 2015-09-18 | 2019-06-25 | Tendyne Holdings, Inc. | Methods for delivery of prosthetic mitral valves |
US10376364B2 (en) | 2015-11-10 | 2019-08-13 | Edwards Lifesciences Corporation | Implant delivery capsule |
US10470876B2 (en) | 2015-11-10 | 2019-11-12 | Edwards Lifesciences Corporation | Transcatheter heart valve for replacing natural mitral valve |
CN108430391B (en) | 2015-12-03 | 2020-09-08 | 坦迪尼控股股份有限公司 | Frame features for prosthetic mitral valves |
CN108366859B (en) | 2015-12-28 | 2021-02-05 | 坦迪尼控股股份有限公司 | Atrial capsular bag closure for prosthetic heart valves |
US10342660B2 (en) | 2016-02-02 | 2019-07-09 | Boston Scientific Inc. | Tensioned sheathing aids |
US10179043B2 (en) | 2016-02-12 | 2019-01-15 | Edwards Lifesciences Corporation | Prosthetic heart valve having multi-level sealing member |
WO2017165842A1 (en) | 2016-03-24 | 2017-09-28 | Edwards Lifesciences Corporation | Delivery system for prosthetic heart valve |
US10470877B2 (en) | 2016-05-03 | 2019-11-12 | Tendyne Holdings, Inc. | Apparatus and methods for anterior valve leaflet management |
US10583005B2 (en) | 2016-05-13 | 2020-03-10 | Boston Scientific Scimed, Inc. | Medical device handle |
US10201416B2 (en) | 2016-05-16 | 2019-02-12 | Boston Scientific Scimed, Inc. | Replacement heart valve implant with invertible leaflets |
WO2017218375A1 (en) | 2016-06-13 | 2017-12-21 | Tendyne Holdings, Inc. | Sequential delivery of two-part prosthetic mitral valve |
CN109640887B (en) | 2016-06-30 | 2021-03-16 | 坦迪尼控股股份有限公司 | Prosthetic heart valve and apparatus and method for delivering same |
EP3484411A1 (en) | 2016-07-12 | 2019-05-22 | Tendyne Holdings, Inc. | Apparatus and methods for trans-septal retrieval of prosthetic heart valves |
US11096781B2 (en) | 2016-08-01 | 2021-08-24 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US10959841B2 (en) * | 2016-11-15 | 2021-03-30 | Hancock Jaffe Laboratories, Inc. | Implantable vein frame |
US10463484B2 (en) | 2016-11-17 | 2019-11-05 | Edwards Lifesciences Corporation | Prosthetic heart valve having leaflet inflow below frame |
US10973631B2 (en) | 2016-11-17 | 2021-04-13 | Edwards Lifesciences Corporation | Crimping accessory device for a prosthetic valve |
US10603165B2 (en) | 2016-12-06 | 2020-03-31 | Edwards Lifesciences Corporation | Mechanically expanding heart valve and delivery apparatus therefor |
IT201700001625A1 (en) * | 2017-01-10 | 2018-07-10 | Tarabini Carlo Castellani | CORRECTIVE PROSTHESIS FOR PROLASSED BIOLOGICAL VASES |
US11013600B2 (en) | 2017-01-23 | 2021-05-25 | Edwards Lifesciences Corporation | Covered prosthetic heart valve |
US11654023B2 (en) | 2017-01-23 | 2023-05-23 | Edwards Lifesciences Corporation | Covered prosthetic heart valve |
US11185406B2 (en) | 2017-01-23 | 2021-11-30 | Edwards Lifesciences Corporation | Covered prosthetic heart valve |
US11135056B2 (en) | 2017-05-15 | 2021-10-05 | Edwards Lifesciences Corporation | Devices and methods of commissure formation for prosthetic heart valve |
CN110650711B (en) | 2017-05-22 | 2022-04-01 | 爱德华兹生命科学公司 | Valve anchors and methods of installation |
US20210401571A9 (en) | 2017-05-31 | 2021-12-30 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US10869759B2 (en) | 2017-06-05 | 2020-12-22 | Edwards Lifesciences Corporation | Mechanically expandable heart valve |
US11026785B2 (en) | 2017-06-05 | 2021-06-08 | Edwards Lifesciences Corporation | Mechanically expandable heart valve |
WO2018226915A1 (en) | 2017-06-08 | 2018-12-13 | Boston Scientific Scimed, Inc. | Heart valve implant commissure support structure |
US11154399B2 (en) | 2017-07-13 | 2021-10-26 | Tendyne Holdings, Inc. | Prosthetic heart valves and apparatus and methods for delivery of same |
US10918473B2 (en) | 2017-07-18 | 2021-02-16 | Edwards Lifesciences Corporation | Transcatheter heart valve storage container and crimping mechanism |
CN111163729B (en) | 2017-08-01 | 2022-03-29 | 波士顿科学国际有限公司 | Medical implant locking mechanism |
IL301081A (en) | 2017-08-11 | 2023-05-01 | Edwards Lifesciences Corp | Sealing element for prosthetic heart valve |
US11083575B2 (en) | 2017-08-14 | 2021-08-10 | Edwards Lifesciences Corporation | Heart valve frame design with non-uniform struts |
US10932903B2 (en) | 2017-08-15 | 2021-03-02 | Edwards Lifesciences Corporation | Skirt assembly for implantable prosthetic valve |
US10939996B2 (en) | 2017-08-16 | 2021-03-09 | Boston Scientific Scimed, Inc. | Replacement heart valve commissure assembly |
US10898319B2 (en) | 2017-08-17 | 2021-01-26 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US10973628B2 (en) | 2017-08-18 | 2021-04-13 | Edwards Lifesciences Corporation | Pericardial sealing member for prosthetic heart valve |
US10722353B2 (en) | 2017-08-21 | 2020-07-28 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
JP7291124B2 (en) | 2017-08-28 | 2023-06-14 | テンダイン ホールディングス,インコーポレイテッド | Heart valve prosthesis with tethered connections |
US10973629B2 (en) | 2017-09-06 | 2021-04-13 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US11147667B2 (en) | 2017-09-08 | 2021-10-19 | Edwards Lifesciences Corporation | Sealing member for prosthetic heart valve |
US20190328511A1 (en) * | 2018-01-16 | 2019-10-31 | Brigham Young University | Prosthetic venous valve devices and associated methods |
US11246625B2 (en) | 2018-01-19 | 2022-02-15 | Boston Scientific Scimed, Inc. | Medical device delivery system with feedback loop |
JP7055882B2 (en) | 2018-01-19 | 2022-04-18 | ボストン サイエンティフィック サイムド,インコーポレイテッド | Guidance mode indwelling sensor for transcatheter valve system |
US11147668B2 (en) | 2018-02-07 | 2021-10-19 | Boston Scientific Scimed, Inc. | Medical device delivery system with alignment feature |
WO2019165394A1 (en) | 2018-02-26 | 2019-08-29 | Boston Scientific Scimed, Inc. | Embedded radiopaque marker in adaptive seal |
US11318011B2 (en) | 2018-04-27 | 2022-05-03 | Edwards Lifesciences Corporation | Mechanically expandable heart valve with leaflet clamps |
CN112399836A (en) | 2018-05-15 | 2021-02-23 | 波士顿科学国际有限公司 | Replacement heart valve commissure assemblies |
WO2019224577A1 (en) | 2018-05-23 | 2019-11-28 | Sorin Group Italia S.R.L. | A cardiac valve prosthesis |
US11241310B2 (en) | 2018-06-13 | 2022-02-08 | Boston Scientific Scimed, Inc. | Replacement heart valve delivery device |
KR20210082188A (en) | 2018-10-19 | 2021-07-02 | 에드워즈 라이프사이언시스 코포레이션 | Artificial heart valve with non-cylindrical frame |
WO2020123486A1 (en) | 2018-12-10 | 2020-06-18 | Boston Scientific Scimed, Inc. | Medical device delivery system including a resistance member |
US11566609B2 (en) * | 2019-01-11 | 2023-01-31 | Baseline Design Innovations Inc. | Portable air pump with rapid inflation |
CN113891686A (en) | 2019-01-23 | 2022-01-04 | 内奥瓦斯克医疗有限公司 | Flow-altering device with cover |
WO2020198273A2 (en) | 2019-03-26 | 2020-10-01 | Edwards Lifesciences Corporation | Prosthetic heart valve |
US11439504B2 (en) | 2019-05-10 | 2022-09-13 | Boston Scientific Scimed, Inc. | Replacement heart valve with improved cusp washout and reduced loading |
EP3831343B1 (en) | 2019-12-05 | 2024-01-31 | Tendyne Holdings, Inc. | Braided anchor for mitral valve |
US11648114B2 (en) | 2019-12-20 | 2023-05-16 | Tendyne Holdings, Inc. | Distally loaded sheath and loading funnel |
US11951002B2 (en) | 2020-03-30 | 2024-04-09 | Tendyne Holdings, Inc. | Apparatus and methods for valve and tether fixation |
WO2021257774A1 (en) | 2020-06-18 | 2021-12-23 | Edwards Lifesciences Corporation | Crimping methods |
WO2022039853A1 (en) | 2020-08-19 | 2022-02-24 | Tendyne Holdings, Inc. | Fully-transseptal apical pad with pulley for tensioning |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4247292A (en) * | 1979-06-06 | 1981-01-27 | Angell William W | Natural tissue heart valve fixation process |
US4692164A (en) * | 1986-03-06 | 1987-09-08 | Moskovskoe Vysshee Tekhnicheskoe Uchilische, Imeni N.E. Baumana | Bioprosthetic heart valve, methods and device for preparation thereof |
WO1988000459A1 (en) * | 1986-07-17 | 1988-01-28 | Quotidian No. 100 Pty. Limited | Prosthetic venous valve |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2127903A (en) * | 1936-05-05 | 1938-08-23 | Davis & Geck Inc | Tube for surgical purposes and method of preparing and using the same |
US2453056A (en) * | 1947-03-12 | 1948-11-02 | Zack William Edwin | Surgical anastomosis apparatus and method |
US2832078A (en) * | 1956-10-17 | 1958-04-29 | Battelle Memorial Institute | Heart valve |
US3254650A (en) * | 1962-03-19 | 1966-06-07 | Michael B Collito | Surgical anastomosis methods and devices |
US3254651A (en) * | 1962-09-12 | 1966-06-07 | Babies Hospital | Surgical anastomosis methods and devices |
US3736598A (en) * | 1971-06-10 | 1973-06-05 | B Bellhouse | Prosthetic cardiac valve |
US3974526A (en) * | 1973-07-06 | 1976-08-17 | Dardik Irving I | Vascular prostheses and process for producing the same |
US3988782A (en) * | 1973-07-06 | 1976-11-02 | Dardik Irving I | Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same |
US3966401A (en) * | 1974-07-01 | 1976-06-29 | Hancock Laboratories Incorporated | Preparing natural tissue for implantation so as to provide improved flexibility |
US4118806A (en) * | 1976-02-04 | 1978-10-10 | Thermo Electron Corporation | Prosthetic blood vessel |
US4056854A (en) * | 1976-09-28 | 1977-11-08 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Aortic heart valve catheter |
US4086665A (en) * | 1976-12-16 | 1978-05-02 | Thermo Electron Corporation | Artificial blood conduit |
DE2657255A1 (en) * | 1976-12-17 | 1978-06-29 | P H Dr Schomacher | DEVICE FOR CLOSING SEPARATED BODY BARRELS |
US4214586A (en) * | 1978-11-30 | 1980-07-29 | Ethicon, Inc. | Anastomotic coupling device |
SE424045B (en) * | 1979-01-12 | 1982-06-28 | Tesi Ab | CATHETER |
NL7906691A (en) * | 1979-09-07 | 1981-03-10 | Jansen Anton | MEDICAL DEVICE FOR COUPLING TWO Bowel Sections, Auxiliary Device For Using It And Method Of Laying A Gut Knot Using This Device. |
US4352358A (en) * | 1979-12-28 | 1982-10-05 | Angelchik Jean P | Apparatus for effecting anastomotic procedures |
JPH0121984B2 (en) * | 1980-07-01 | 1989-04-24 | Betsuteibetopirai Kesaranazan | |
US4340977A (en) * | 1980-09-19 | 1982-07-27 | Brownlee Richard T | Catenary mitral valve replacement |
US4366819A (en) * | 1980-11-17 | 1983-01-04 | Kaster Robert L | Anastomotic fitting |
US4816029A (en) * | 1981-05-07 | 1989-03-28 | Medtronic, Inc. | Stent for aortic heart valve |
US4372743A (en) * | 1981-06-22 | 1983-02-08 | American Hospital Supply Corp. | Low-pressure fixation of valvular tissue intended for implantation |
US4350492A (en) * | 1981-08-24 | 1982-09-21 | Vascor, Inc. | Method for preparing tissue heart valve |
US4451936A (en) * | 1981-12-21 | 1984-06-05 | American Hospital Supply Corporation | Supra-annular aortic valve |
DE3207690A1 (en) * | 1982-03-01 | 1983-09-08 | Karl-Egon Dr. med. 1000 Berlin Gaul | Venous valve prosthesis/artificial venous valve |
US4670286A (en) * | 1983-09-20 | 1987-06-02 | Allied Corporation | Method of forming prosthetic devices |
US4657019A (en) * | 1984-04-10 | 1987-04-14 | Idea Research Investment Fund, Inc. | Anastomosis devices and kits |
BR8404772A (en) * | 1984-09-21 | 1986-04-29 | Mario Osvaldo Vrandecic Peredo | HETEROLOGICAL ARTERIAL BIOENGESTURE AND PROCESS FOR THE TREATMENT OF BIOLOGICAL MATERIAL |
US4728328A (en) * | 1984-10-19 | 1988-03-01 | Research Corporation | Cuffed tubular organic prostheses |
US4704126A (en) * | 1985-04-15 | 1987-11-03 | Richards Medical Company | Chemical polishing process for titanium and titanium alloy surgical implants |
DE3605306A1 (en) * | 1986-02-19 | 1987-08-20 | Ekkehard Dr Euler | DEVICE FOR MACRO- AND MICRO-SURGICAL CONNECTION OF VESSELS |
US4725274A (en) * | 1986-10-24 | 1988-02-16 | Baxter Travenol Laboratories, Inc. | Prosthetic heart valve |
JPH0763489B2 (en) * | 1986-10-31 | 1995-07-12 | 宇部興産株式会社 | Medical tube |
US5108430A (en) * | 1987-02-20 | 1992-04-28 | Biagio Ravo | Implantable reservoir adapted to receive and store structural devices therein |
US5089014A (en) * | 1987-05-18 | 1992-02-18 | Holfert John W | Tubular interconnect device for use within the circulatory system |
US4851000A (en) * | 1987-07-31 | 1989-07-25 | Pacific Biomedical Holdings, Ltd. | Bioprosthetic valve stent |
US4851001A (en) * | 1987-09-17 | 1989-07-25 | Taheri Syde A | Prosthetic valve for a blood vein and an associated method of implantation of the valve |
US4938740A (en) * | 1988-05-25 | 1990-07-03 | Trustees Of The University Of Pennsylvania | Reducing stress at vascular graft anastomoses |
US5192289A (en) * | 1989-03-09 | 1993-03-09 | Avatar Design And Development, Inc. | Anastomosis stent and stent selection system |
WO1990014804A1 (en) * | 1989-05-31 | 1990-12-13 | Baxter International Inc. | Biological valvular prosthesis |
WO1993000868A1 (en) * | 1991-07-04 | 1993-01-21 | Earl Ronald Owen | Tubular surgical implant |
-
1990
- 1990-05-31 WO PCT/US1990/003053 patent/WO1990014804A1/en active IP Right Grant
- 1990-05-31 CA CA2054728A patent/CA2054728C/en not_active Expired - Lifetime
- 1990-05-31 JP JP02508828A patent/JP3127378B2/en not_active Expired - Lifetime
- 1990-05-31 DE DE69016426T patent/DE69016426T2/en not_active Expired - Lifetime
- 1990-05-31 DK DK90909072.2T patent/DK0474748T3/en active
- 1990-05-31 EP EP90909072A patent/EP0474748B1/en not_active Expired - Lifetime
-
1994
- 1994-05-09 US US08/240,286 patent/US5500014A/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4247292A (en) * | 1979-06-06 | 1981-01-27 | Angell William W | Natural tissue heart valve fixation process |
US4692164A (en) * | 1986-03-06 | 1987-09-08 | Moskovskoe Vysshee Tekhnicheskoe Uchilische, Imeni N.E. Baumana | Bioprosthetic heart valve, methods and device for preparation thereof |
WO1988000459A1 (en) * | 1986-07-17 | 1988-01-28 | Quotidian No. 100 Pty. Limited | Prosthetic venous valve |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5500014A (en) * | 1989-05-31 | 1996-03-19 | Baxter International Inc. | Biological valvular prothesis |
US5997573A (en) * | 1989-05-31 | 1999-12-07 | Baxter International, Inc. | Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts |
US5609626A (en) * | 1989-05-31 | 1997-03-11 | Baxter International Inc. | Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts |
EP0520126A1 (en) * | 1991-06-25 | 1992-12-30 | Sante Camilli | Artificial venous value |
AU671079B2 (en) * | 1991-08-29 | 1996-08-15 | Medtronic, Inc. | Natural tissue heart valve fixation |
WO1993004643A1 (en) * | 1991-08-29 | 1993-03-18 | Medtronic, Inc. | Natural tissue heart valve fixation |
WO1993020757A3 (en) * | 1992-04-21 | 1994-01-06 | Baxter Int | Vascular implant system |
WO1993020757A2 (en) * | 1992-04-21 | 1993-10-28 | Baxter International Inc. | Vascular implant system |
US5824060A (en) * | 1993-09-29 | 1998-10-20 | Medtronic, Inc. | Natural tissue heart valve fixation |
US6102845A (en) * | 1994-02-07 | 2000-08-15 | Baxter International Inc. | Ventricular assist device with minimal blood contacting surfaces |
US5810708A (en) * | 1994-02-07 | 1998-09-22 | Baxter International Inc. | Ventricular assist conduit with externally supported tissue valve |
US5545215A (en) * | 1994-09-14 | 1996-08-13 | Duran; Carlos G. | External sigmoid valve complex frame and valved conduit supported by the same |
WO1996019159A1 (en) * | 1994-12-21 | 1996-06-27 | Claude Franceschi | Artificial valve for a blood vessel |
FR2728457A1 (en) * | 1994-12-21 | 1996-06-28 | Franceschi Claude | ARTIFICIAL VALVE FOR BLOOD VESSEL |
US5830239A (en) * | 1995-11-15 | 1998-11-03 | Medtronic, Inc. | Natural tissue heart valve fixation apparatus and method |
US5865723A (en) * | 1995-12-29 | 1999-02-02 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
WO1997024081A1 (en) * | 1995-12-29 | 1997-07-10 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
EP0808614A3 (en) * | 1996-05-23 | 1998-11-11 | SAMSUNG ELECTRONICS Co. Ltd. | Flexible self-expandable stent and method for making the same |
EP0808614A2 (en) * | 1996-05-23 | 1997-11-26 | SAMSUNG ELECTRONICS Co. Ltd. | Flexible self-expandable stent and method for making the same |
US6494904B1 (en) | 1996-12-27 | 2002-12-17 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
US6001056A (en) * | 1998-11-13 | 1999-12-14 | Baxter International Inc. | Smooth ventricular assist device conduit |
EP1057460A1 (en) * | 1999-06-01 | 2000-12-06 | Numed, Inc. | Replacement valve assembly and method of implanting same |
WO2002017819A3 (en) * | 2000-08-29 | 2002-10-03 | Alexander Shaknovich | Method and devices for decreasing elevated pulmonary venous pressure |
US6572652B2 (en) | 2000-08-29 | 2003-06-03 | Venpro Corporation | Method and devices for decreasing elevated pulmonary venous pressure |
US7048757B2 (en) | 2000-08-29 | 2006-05-23 | Alexander Shaknovich | Method and devices for decreasing elevated pulmonary venous pressure |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
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US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
WO2009000546A1 (en) * | 2007-06-27 | 2008-12-31 | Aesculap Ag | Aortic sinus prosthesis |
US11577004B2 (en) | 2007-10-17 | 2023-02-14 | Envveno Medical Corporation | Biological valve for venous insufficiency |
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Also Published As
Publication number | Publication date |
---|---|
DE69016426D1 (en) | 1995-03-09 |
DK0474748T3 (en) | 1995-05-01 |
CA2054728A1 (en) | 1990-12-01 |
JP3127378B2 (en) | 2001-01-22 |
CA2054728C (en) | 2003-07-29 |
JPH04505866A (en) | 1992-10-15 |
DE69016426T2 (en) | 1995-08-17 |
US5500014A (en) | 1996-03-19 |
EP0474748B1 (en) | 1995-01-25 |
EP0474748A1 (en) | 1992-03-18 |
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