WO1991002062A3 - C-erbb-2 external domain: gp75 - Google Patents

C-erbb-2 external domain: gp75 Download PDF

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Publication number
WO1991002062A3
WO1991002062A3 PCT/US1990/004340 US9004340W WO9102062A3 WO 1991002062 A3 WO1991002062 A3 WO 1991002062A3 US 9004340 W US9004340 W US 9004340W WO 9102062 A3 WO9102062 A3 WO 9102062A3
Authority
WO
WIPO (PCT)
Prior art keywords
erbb
polypeptides
disclosed
proteins
useful
Prior art date
Application number
PCT/US1990/004340
Other languages
French (fr)
Other versions
WO1991002062A2 (en
Inventor
Susan G Stuart
John J Monahan
Beatrice Claudia Langton
Miriam E C Hancock
Lorrine A Chao
Peter Bluford
Original Assignee
Triton Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23540312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1991002062(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Triton Biosciences Inc filed Critical Triton Biosciences Inc
Priority to AT90914094T priority Critical patent/ATE207958T1/en
Priority to DK90914094T priority patent/DK0444181T3/en
Priority to CA002042064A priority patent/CA2042064C/en
Priority to DE69033842T priority patent/DE69033842T2/en
Priority to EP90914094A priority patent/EP0444181B2/en
Publication of WO1991002062A2 publication Critical patent/WO1991002062A2/en
Publication of WO1991002062A3 publication Critical patent/WO1991002062A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins

Abstract

Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor burden. Further disclosed are recombinant, synthetically and otherwise biologically produced novel proteins and polypeptides which are encoded by the external domain DNA sequence of the c-erbB-2 oncogene (the gp75 gene) or fragments thereof. Such gp75 proteins and polypeptides are useful as vaccines, therapeutically in the treatment of cancer either alone or in combination with chemotherapeutic agents. Also disclosed are antibodies to such gp75 proteins and polypeptides which are useful diagnostically and therapeutically. Still further disclosed are test kits embodying the assays of this invention.
PCT/US1990/004340 1989-08-04 1990-08-02 C-erbb-2 external domain: gp75 WO1991002062A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT90914094T ATE207958T1 (en) 1989-08-04 1990-08-02 EXTERNAL DOMAIN OF C-ERBB-2:GP75
DK90914094T DK0444181T3 (en) 1989-08-04 1990-08-02 C-erbB-2 External Domain: gp75
CA002042064A CA2042064C (en) 1989-08-04 1990-08-02 C-erbb-2 external domain:gp75
DE69033842T DE69033842T2 (en) 1989-08-04 1990-08-02 OUTSIDE DOMAIN OF C-ERBB-2: GP75
EP90914094A EP0444181B2 (en) 1989-08-04 1990-08-02 C-erbb-2 external domain: gp75

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38992089A 1989-08-04 1989-08-04
US389,920 1989-08-04

Publications (2)

Publication Number Publication Date
WO1991002062A2 WO1991002062A2 (en) 1991-02-21
WO1991002062A3 true WO1991002062A3 (en) 1991-06-13

Family

ID=23540312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/004340 WO1991002062A2 (en) 1989-08-04 1990-08-02 C-erbb-2 external domain: gp75

Country Status (10)

Country Link
US (2) US20020155527A1 (en)
EP (2) EP0444181B2 (en)
JP (2) JP3859695B2 (en)
AT (1) ATE207958T1 (en)
AU (1) AU645760B2 (en)
CA (1) CA2042064C (en)
DE (1) DE69033842T2 (en)
DK (1) DK0444181T3 (en)
ES (1) ES2166352T3 (en)
WO (1) WO1991002062A2 (en)

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US8940302B2 (en) 2007-03-02 2015-01-27 Genentech, Inc. Predicting response to a HER inhibitor
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells

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WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
DK0474727T3 (en) * 1989-05-19 1998-01-12 Genentech Inc HER2 extracellular domain
JP2895105B2 (en) * 1989-09-14 1999-05-24 株式会社ニチレイ Serodiagnosis method for breast cancer by immunoassay of c-erbB-2 oncogene product and kit therefor
IE20000918A1 (en) 1990-03-22 2001-05-30 Sloan Kettering Inst Cancer GP75 As a Tumor Vaccine for Melanoma
US5801005A (en) * 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US6953573B1 (en) 1993-03-17 2005-10-11 University Of Washington Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated
US5869445A (en) * 1993-03-17 1999-02-09 University Of Washington Methods for eliciting or enhancing reactivity to HER-2/neu protein
ATE186219T1 (en) * 1993-03-24 1999-11-15 Berlex Biosciences COMBINATION OF ANTIHORMONAL AND BINDING MOLECULES FOR CANCER TREATMENT
IT1264083B1 (en) * 1993-12-10 1996-09-10 Enea Ente Nuove Tec PROCEDURE FOR THE PRODUCTION IN PLANTS OF ENGINEERED ANTIBODY, PRODUCED ANTIBODY AND THEIR USE IN DIAGNOSIS AND THERAPY.
US5783404A (en) * 1995-04-13 1998-07-21 Amgen Inc. Methods and compositions for determining HER-2/neu expression using monoclonal antibodies
US5759776A (en) * 1995-06-05 1998-06-02 California Pacific Medical Center Targets for breast cancer diagnosis and treatment
US6225054B1 (en) 1996-01-11 2001-05-01 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
US6861506B1 (en) 1996-01-11 2005-03-01 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
KR19990077146A (en) * 1996-01-11 1999-10-25 길리스 스티브 Compositions and methods for treating and diagnosing breast cancer
US7241876B2 (en) 1996-01-11 2007-07-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US6423496B1 (en) 1996-01-11 2002-07-23 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
US6344550B1 (en) 1996-01-11 2002-02-05 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
US6586570B1 (en) 1996-01-11 2003-07-01 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
US6656480B2 (en) 1996-01-11 2003-12-02 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
US6828431B1 (en) 1999-04-09 2004-12-07 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
WO1997038085A2 (en) * 1996-04-10 1997-10-16 California Pacific Medical Center Genes amplified in cancer cells
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
ATE235890T1 (en) 1997-01-30 2003-04-15 Chiron Corp USE OF MICROPARTICLES WITH ADSORBED ANTIGEN TO STIMULATE IMMUNE DEFENSE
ZA982968B (en) * 1997-04-09 1998-10-27 Corixa Corp Compositions and methods for the treatment and diagnosis of breast cancer
ZA9811162B (en) 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
US7625859B1 (en) 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US7396810B1 (en) * 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7198920B1 (en) 1999-01-29 2007-04-03 Corika Corporation HER-2/neu fusion proteins
US6294349B1 (en) 1999-03-01 2001-09-25 University Of Mississippi Medical Ctr. Method of diagnosing and monitoring malignant breast carcinomas
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
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US20030086924A1 (en) * 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
US6949245B1 (en) * 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
US7041292B1 (en) 1999-06-25 2006-05-09 Genentech, Inc. Treating prostate cancer with anti-ErbB2 antibodies
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AU2001259271A1 (en) * 2000-04-28 2001-11-12 Millennium Pharmaceuticals, Inc. 14094, a novel human trypsin family member and uses thereof
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EP2305299B1 (en) 2001-05-31 2017-03-01 GlaxoSmithKline Biologicals SA Chimeric alphavirus replicon particles
CN100424175C (en) 2002-03-26 2008-10-08 上海泽生科技开发有限公司 Methods and compositions for treating neoplasms by ERBB3
WO2004048525A2 (en) * 2002-11-21 2004-06-10 Genentech, Inc. Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies
WO2005016966A2 (en) * 2003-05-16 2005-02-24 Receptor Biologix, Inc. Intron fusion proteins, and methods of identifying and using same
EP1745073A2 (en) * 2004-05-14 2007-01-24 Receptor Biologix, Inc. Cell surface receptor isoforms and methods of identifying and using the same
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
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US20080206231A1 (en) * 2004-10-05 2008-08-28 Oregon Health And Science University Compositions and Methods for Treating Disease
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JP5981853B2 (en) 2010-02-18 2016-08-31 ジェネンテック， インコーポレイテッド Neuregulin antagonists and their use in the treatment of cancer
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8940302B2 (en) 2007-03-02 2015-01-27 Genentech, Inc. Predicting response to a HER inhibitor
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells

Also Published As

Publication number Publication date
EP1006194A2 (en) 2000-06-07
DE69033842D1 (en) 2001-12-06
JP3859695B2 (en) 2006-12-20
WO1991002062A2 (en) 1991-02-21
DE69033842T2 (en) 2002-06-20
US20060019344A1 (en) 2006-01-26
ES2166352T3 (en) 2002-04-16
AU645760B2 (en) 1994-01-27
CA2042064C (en) 2008-10-21
US20020155527A1 (en) 2002-10-24
EP0444181B2 (en) 2010-11-24
DK0444181T3 (en) 2002-02-25
ATE207958T1 (en) 2001-11-15
EP0444181B1 (en) 2001-10-31
JP2006304807A (en) 2006-11-09
AU6413590A (en) 1991-03-11
EP1006194A3 (en) 2008-07-02
EP0444181A1 (en) 1991-09-04
JPH04503012A (en) 1992-06-04
CA2042064A1 (en) 1991-02-05

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