WO1991011496A1 - Neue treibgase und ihre verwendung in arzneimittelzubereitungen - Google Patents
Neue treibgase und ihre verwendung in arzneimittelzubereitungen Download PDFInfo
- Publication number
- WO1991011496A1 WO1991011496A1 PCT/EP1991/000178 EP9100178W WO9111496A1 WO 1991011496 A1 WO1991011496 A1 WO 1991011496A1 EP 9100178 W EP9100178 W EP 9100178W WO 9111496 A1 WO9111496 A1 WO 9111496A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mentioned
- propellant gases
- combination
- active
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/30—Materials not provided for elsewhere for aerosols
Definitions
- the invention relates to new propellant gases in which 1,1,1,2,3,3,3-heptafluoropropane (TG 227) is contained as a typical component, ie the use of these propellant gases in pharmaceutical preparations which are suitable for producing aerosols. as well as these pharmaceutical preparations themselves.
- TG 227 1,1,1,2,3,3,3-heptafluoropropane
- Aerosols of powdered (nicronized) drugs are widely used in therapy, e.g. used in the therapy of obstructive respiratory diseases. Insofar as such aerosols are not produced by atomizing the medicinal powder or by spraying solutions, suspensions of the medicinal substances in liquefied propellant gases are used.
- Mixtures of TG 11 (trichlorofluoromethane), TG 12 (dichlorodifluoromethane) and TG 114 (1,2-dichloro-1,2,2,2-tetrafluoroethane) are used as such, optionally with the addition of lower alkanes, such as butane or pentane or also from DME (dimethyl ether). Mixtures of this type are known, for example, from German patent 1178975.
- TG 227 (1,1,1,2,3,3,3-heptafluoropropane), optionally in a mixture with one or more propellants from the group TG 11 (trichlorofluoromethane), TG 12 (dichlorodifluoromethane), is TG 114
- the components that can be used in addition to TG 227 are added if the properties of the propellant are to be modified, e.g. if a different density of the liquefied propellant gas, a different pressure or a different dissolving behavior is to be set.
- Pharmaceutical preparations based on the new propellant contain an active ingredient in finely divided form, usually as a suspension, and generally also surface-active substances, such as a phospholipid (such as lecithin), an ester of a polyalcohol (such as sorbitol) with higher saturated or unsaturated fatty acids (e.g.
- stearin Palmitic, oleic acid
- sorbitan trioleate for example sorbitan trioleate
- polyethoxysorbitan ester of a higher, preferably unsaturated fatty acid The excipient can be dissolved or undissolved in the mixture.
- Mixture components of the propellant gas can be varied within wide limits.
- the proportion (in percent by weight) for TG 227 is 10 to 100%.
- the mixture can moreover up to 50% propane and / or butane and / or pentane and / or DME and / or TG 11, and / or TG 12 and / or TG 114 included. Within the limits mentioned, the components are selected so that a total of 100% results. Propellant gas mixtures containing 30 to 100% TG 227 are preferred.
- the proportion of the suspended drug in the finished preparation is between 0.001 and 5%, preferably 0.005 to 3%, in particular 0.01 to 2%.
- the surface-active substances are added in amounts of 0.01 to 10%, preferably 0.05 to 5%, in particular 0.1 to 3% (here, as with the medicinal substances, percent by weight of the finished preparation is indicated). All substances that are suitable for inhalation, and possibly also for intranasal use, can serve as medicinal substances in the new preparations. Accordingly, they are, in particular, betamimetics, anticholinergics, steroids, antiallergics, PAF antagonists and combinations of such active ingredients.
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91903267A EP0513099B1 (de) | 1990-02-03 | 1991-01-31 | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
CA002075060A CA2075060C (en) | 1990-02-03 | 1991-01-31 | Novel vehicle gases and their use in medical preparations |
HU9202508A HU218664B (hu) | 1990-02-03 | 1991-01-31 | Eljárás új, hajtógázokat tartalmazó gyógyszerszuszpenziók előállítására |
KR1019920701826A KR920703034A (ko) | 1990-02-03 | 1991-01-31 | 분사 가스 및 약제학적 제제중에서의 이의 용도 |
DK91903267T DK0513099T3 (da) | 1990-02-03 | 1991-01-31 | Nye drivgasser og deres anvendelse i lægemiddelpræparater |
DE59109161T DE59109161D1 (de) | 1990-02-03 | 1991-01-31 | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
AU72116/91A AU656129B2 (en) | 1990-02-03 | 1991-01-31 | Novel vehicle gases and their use in medical preparations |
NO923040A NO302420B1 (no) | 1990-02-03 | 1992-07-31 | Legemiddelsuspensjoner i flytendegjorte drivgasser for dannelse av inhaleringsaerosoler, samt anvendelse av 1,1,1,2,3,3,3-heptafluorpropan som drivmiddel |
FI923491A FI103348B1 (fi) | 1990-02-03 | 1992-08-03 | Menetelmä lääkeainesuspension valmistamiseksi |
HK98111443A HK1010737A1 (en) | 1990-02-03 | 1998-10-21 | Novel vehicle gases and their use in medical preparations |
GR990403262T GR3032176T3 (en) | 1990-02-03 | 1999-12-17 | Novel vehicle gases and their use in medical preparations. |
US09/525,431 US6419899B1 (en) | 1990-01-31 | 2000-03-14 | Suspension aerosol formulations of pharmaceutical products |
US10/072,400 US20020071812A1 (en) | 1990-01-31 | 2002-02-06 | Propellent gases and their use in pharmaceutical preparations |
US10/638,987 US20040028618A1 (en) | 1990-02-03 | 2003-08-12 | Suspension aerosol formulations of pharmaceutical products |
US10/934,611 US7160538B2 (en) | 1990-02-03 | 2004-09-03 | Suspension aerosol formulations of pharmaceutical products |
US11/553,508 US20070065370A1 (en) | 1990-02-03 | 2006-10-27 | Suspension aerosol formulationis of pharmaceutical products |
US12/179,785 US20090104127A1 (en) | 1990-02-03 | 2008-07-25 | Suspension aerosol formulations of pharmaceutical products |
US12/891,076 US20110014134A1 (en) | 1990-02-03 | 2010-09-27 | Suspension aerosol formulations of pharmaceutical products |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4003270.1 | 1990-02-03 | ||
DE4003270A DE4003270A1 (de) | 1990-02-03 | 1990-02-03 | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991011496A1 true WO1991011496A1 (de) | 1991-08-08 |
Family
ID=6399399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1991/000178 WO1991011496A1 (de) | 1990-01-31 | 1991-01-31 | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
Country Status (26)
Country | Link |
---|---|
US (7) | US6419899B1 (de) |
EP (1) | EP0513099B1 (de) |
JP (1) | JP3497162B2 (de) |
KR (1) | KR920703034A (de) |
AT (1) | ATE185587T1 (de) |
AU (1) | AU656129B2 (de) |
CA (1) | CA2075060C (de) |
CZ (1) | CZ285209B6 (de) |
DE (2) | DE4003270A1 (de) |
DK (1) | DK0513099T3 (de) |
ES (1) | ES2139574T3 (de) |
FI (1) | FI103348B1 (de) |
GR (1) | GR3032176T3 (de) |
HK (1) | HK1010737A1 (de) |
HR (1) | HRP940737B1 (de) |
HU (1) | HU218664B (de) |
IL (1) | IL97024A0 (de) |
NO (1) | NO302420B1 (de) |
NZ (1) | NZ236974A (de) |
PT (1) | PT96635B (de) |
RU (1) | RU2118170C1 (de) |
SI (1) | SI9110155B (de) |
SK (1) | SK281440B6 (de) |
WO (1) | WO1991011496A1 (de) |
YU (1) | YU48509B (de) |
ZA (1) | ZA91756B (de) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0518600A1 (de) * | 1991-06-10 | 1992-12-16 | Schering Corporation | Nichtchlorfluorkohlenstoff-Aerosolformulierungen |
WO1993004671A1 (en) * | 1991-09-03 | 1993-03-18 | Minnesota Mining And Manufacturing Company | Medicinal aerosol formulations |
WO1993011743A1 (en) * | 1991-12-12 | 1993-06-24 | Glaxo Group Limited | Medicaments |
WO1994013263A1 (en) * | 1992-12-09 | 1994-06-23 | Jager Paul D | Stabilized medicinal aerosol solution formulations |
EP0768114A2 (de) * | 1995-10-13 | 1997-04-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Verfahren und Vorrichtung zum Homogenisieren von Aerosolformulierungen |
US5653962A (en) * | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
US5658549A (en) * | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
US5674471A (en) * | 1991-12-12 | 1997-10-07 | Glaxo Group Limited | Aerosol formulations containing P134a and salbutamol |
US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
US5744123A (en) * | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
EP0848949A1 (de) * | 1996-12-18 | 1998-06-24 | HERMES Fabrik pharmazeutischer Präparate Franz Gradinger GmbH & Co. | Aerosol enthaltend Vitamin A oder ein Derivat davon |
US5776433A (en) * | 1993-12-20 | 1998-07-07 | Minnesota Mining And Manufacturing Company | Flunisolide aerosol formulations |
US5776432A (en) * | 1990-10-18 | 1998-07-07 | Minnesota Mining And Manufacturing Company | Beclomethasone solution aerosol formulations |
US5817293A (en) * | 1991-12-12 | 1998-10-06 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
US5916540A (en) * | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
US6039932A (en) * | 1996-09-27 | 2000-03-21 | 3M Innovative Properties Company | Medicinal inhalation aerosol formulations containing budesonide |
US6054488A (en) * | 1996-06-11 | 2000-04-25 | 3M Innovative Properties Company | Medicinal aerosol formulations of formoterol |
US6200549B1 (en) | 1991-12-12 | 2001-03-13 | Glaxo Group Limited | Aerosol formulation containing P134a and particulate medicament |
US7101534B1 (en) | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
US7160538B2 (en) | 1990-02-03 | 2007-01-09 | Boehringer Ingelheim Kg | Suspension aerosol formulations of pharmaceutical products |
EP1955694A1 (de) | 2003-07-11 | 2008-08-13 | Boehringer Ingelheim International GmbH | HFC Lösungsformulierungen enthaltend ein Anticholinergikum |
SG158731A1 (en) * | 1999-05-12 | 2010-02-26 | Boehringer Ingelheim Pharma | Novel medicament compositions, based on anticholinergically effective compounds and beta-mimetics |
US9394314B2 (en) | 2012-12-21 | 2016-07-19 | Map Pharmaceuticals, Inc. | 8′-hydroxy-dihydroergotamine compounds and compositions |
US9616060B2 (en) | 2002-04-17 | 2017-04-11 | Nektar Therapeutics | Particulate materials |
US9833451B2 (en) | 2007-02-11 | 2017-12-05 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE114112T1 (de) * | 1990-10-18 | 1994-12-15 | Minnesota Mining & Mfg | Aerosolzubereitung, die beclometason 17,21- dipropionat enthält. |
US5221492A (en) * | 1991-08-23 | 1993-06-22 | E. I. Du Pont De Nemours And Company | Azeotropic mixture of perfluoropropane and dimethyl ether |
US20030103907A1 (en) * | 1991-12-18 | 2003-06-05 | Schultz Robert K. | Suspension aerosol formulations |
US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
DE69233319T2 (de) * | 1991-12-18 | 2005-02-17 | Minnesota Mining & Manufacturing Company, St. Paul | Aerosolzusammensetzungen für Arzneimittelsuspensionen |
AU3936293A (en) * | 1992-03-26 | 1993-10-21 | Great Lakes Chemical Corporation | Azeotrope-like compositions of 1,1,1,2,3,3,3-heptafluoropropane and 1,1-difluoroethane |
MX9704550A (es) | 1994-12-22 | 1997-10-31 | Astra Ab | Formulaciones de medicamentos en aerosol. |
US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
US6706726B2 (en) | 2000-10-14 | 2004-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anticholinergics which may be used as medicaments as well as processes for preparing them |
DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
DE10062712A1 (de) * | 2000-12-15 | 2002-06-20 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden |
DE10130371A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
US7754242B2 (en) * | 2002-03-20 | 2010-07-13 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
US7582284B2 (en) * | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
JP2007509147A (ja) * | 2003-10-20 | 2007-04-12 | シェーリング コーポレイション | 薬学的エアロゾル組成物 |
PL1809243T5 (pl) * | 2004-07-02 | 2022-12-27 | Boehringer Ingelheim International Gmbh | Preparaty aerozolowe w postaci zawiesin z tg 227 ea jako propelent aerozolowy |
JP2008538758A (ja) * | 2005-04-23 | 2008-11-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗コリン作用薬に加えてベータ受容体刺激薬及びステロイドを含有する吸入用の医薬組成物 |
DE102006017320A1 (de) * | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
EP2282418A3 (de) | 2009-06-23 | 2011-03-09 | Alcatel Lucent | Station mit mindestens zwei Sendeantennen und Sendeverfahren dafür |
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EP0384371A1 (de) * | 1989-02-24 | 1990-08-29 | Hoechst Aktiengesellschaft | Druckgaspackung und Treibmittel für Aerosole |
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-
1990
- 1990-02-03 DE DE4003270A patent/DE4003270A1/de not_active Withdrawn
-
1991
- 1991-01-24 IL IL97024A patent/IL97024A0/xx not_active IP Right Cessation
- 1991-01-30 SI SI9110155A patent/SI9110155B/sl unknown
- 1991-01-30 YU YU15591A patent/YU48509B/sh unknown
- 1991-01-31 AT AT91903267T patent/ATE185587T1/de not_active IP Right Cessation
- 1991-01-31 DE DE59109161T patent/DE59109161D1/de not_active Revoked
- 1991-01-31 ES ES91903267T patent/ES2139574T3/es not_active Expired - Lifetime
- 1991-01-31 AU AU72116/91A patent/AU656129B2/en not_active Expired
- 1991-01-31 JP JP50368791A patent/JP3497162B2/ja not_active Expired - Lifetime
- 1991-01-31 RU SU5052884A patent/RU2118170C1/ru active
- 1991-01-31 HU HU9202508A patent/HU218664B/hu unknown
- 1991-01-31 NZ NZ236974A patent/NZ236974A/en unknown
- 1991-01-31 KR KR1019920701826A patent/KR920703034A/ko not_active Application Discontinuation
- 1991-01-31 DK DK91903267T patent/DK0513099T3/da active
- 1991-01-31 WO PCT/EP1991/000178 patent/WO1991011496A1/de not_active Application Discontinuation
- 1991-01-31 CA CA002075060A patent/CA2075060C/en not_active Expired - Lifetime
- 1991-01-31 EP EP91903267A patent/EP0513099B1/de not_active Revoked
- 1991-02-01 ZA ZA91756A patent/ZA91756B/xx unknown
- 1991-02-01 PT PT96635A patent/PT96635B/pt not_active IP Right Cessation
- 1991-02-04 CZ CS91265A patent/CZ285209B6/cs not_active IP Right Cessation
- 1991-02-04 SK SK265-91A patent/SK281440B6/sk not_active IP Right Cessation
-
1992
- 1992-07-31 NO NO923040A patent/NO302420B1/no not_active IP Right Cessation
- 1992-08-03 FI FI923491A patent/FI103348B1/fi active
-
1994
- 1994-10-24 HR HR940737A patent/HRP940737B1/xx not_active IP Right Cessation
-
1998
- 1998-10-21 HK HK98111443A patent/HK1010737A1/xx not_active IP Right Cessation
-
1999
- 1999-12-17 GR GR990403262T patent/GR3032176T3/el unknown
-
2000
- 2000-03-14 US US09/525,431 patent/US6419899B1/en not_active Expired - Fee Related
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2002
- 2002-02-06 US US10/072,400 patent/US20020071812A1/en not_active Abandoned
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2003
- 2003-08-12 US US10/638,987 patent/US20040028618A1/en not_active Abandoned
-
2004
- 2004-09-03 US US10/934,611 patent/US7160538B2/en not_active Expired - Lifetime
-
2006
- 2006-10-27 US US11/553,508 patent/US20070065370A1/en not_active Abandoned
-
2008
- 2008-07-25 US US12/179,785 patent/US20090104127A1/en not_active Abandoned
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2010
- 2010-09-27 US US12/891,076 patent/US20110014134A1/en not_active Abandoned
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