WO1991015222A3 - Method of predisposing mammals to accelerated tissue repair - Google Patents

Method of predisposing mammals to accelerated tissue repair Download PDF

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Publication number
WO1991015222A3
WO1991015222A3 PCT/US1991/001861 US9101861W WO9115222A3 WO 1991015222 A3 WO1991015222 A3 WO 1991015222A3 US 9101861 W US9101861 W US 9101861W WO 9115222 A3 WO9115222 A3 WO 9115222A3
Authority
WO
WIPO (PCT)
Prior art keywords
predisposing
mammals
tissue repair
accelerated tissue
accelerated
Prior art date
Application number
PCT/US1991/001861
Other languages
French (fr)
Other versions
WO1991015222A2 (en
Inventor
Edward P Amento
L Steven Beck
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to JP91507583A priority Critical patent/JPH05506030A/en
Priority to AT91908101T priority patent/ATE102043T1/en
Priority to DE69101316T priority patent/DE69101316T2/en
Publication of WO1991015222A2 publication Critical patent/WO1991015222A2/en
Publication of WO1991015222A3 publication Critical patent/WO1991015222A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A method of predisposing a mammal to accelerated tissue repair is provided. This method comprises systemically administering to the mammal, prior to its exposure to tissue damage, an effective amount of TGF-β. Preferably, the TGF-β is administered no more than about 24 hours prior to exposure to tissue damage.
PCT/US1991/001861 1990-04-04 1991-03-20 Method of predisposing mammals to accelerated tissue repair WO1991015222A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP91507583A JPH05506030A (en) 1990-04-04 1991-03-20 How to predispose mammals to promote tissue repair
AT91908101T ATE102043T1 (en) 1990-04-04 1991-03-20 PRESENTING MAMMALS TO ACCELERATED TISSUE REPAIR.
DE69101316T DE69101316T2 (en) 1990-04-04 1991-03-20 RECEIVING MAMMALS FOR ACCELERATED TISSUE REPAIR.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US504,495 1990-04-04
US07/504,495 US5108989A (en) 1990-04-04 1990-04-04 Method of predisposing mammals to accelerated tissue repair

Publications (2)

Publication Number Publication Date
WO1991015222A2 WO1991015222A2 (en) 1991-10-17
WO1991015222A3 true WO1991015222A3 (en) 1991-11-14

Family

ID=24006516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/001861 WO1991015222A2 (en) 1990-04-04 1991-03-20 Method of predisposing mammals to accelerated tissue repair

Country Status (9)

Country Link
US (1) US5108989A (en)
EP (1) EP0527787B1 (en)
JP (1) JPH05506030A (en)
AT (1) ATE102043T1 (en)
CA (1) CA2078547A1 (en)
DE (1) DE69101316T2 (en)
DK (1) DK0527787T3 (en)
ES (1) ES2052378T3 (en)
WO (1) WO1991015222A2 (en)

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US6723698B2 (en) * 1991-03-11 2004-04-20 Curis, Inc. Methods and compositions for the treatment of motor neuron injury and neuropathy
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6399569B1 (en) * 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US6211146B1 (en) * 1991-03-11 2001-04-03 Curis, Inc. 60A protein-induced morphogenesis
US6506729B1 (en) 1991-03-11 2003-01-14 Curis, Inc. Methods and compositions for the treatment and prevention of Parkinson's disease
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6204240B1 (en) 1991-11-22 2001-03-20 Genentech, Inc. TGF-β1 to improve neural outcome
CA2125279A1 (en) * 1991-12-10 1993-06-24 John Sayler Coon Methods and compositions for reducing multi-drug resistance
US5681812A (en) * 1991-12-10 1997-10-28 Rush Presbyterian-St. Luke's Medical Center Methods and compositions for reducing multidrug resistance
US5767079A (en) * 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
US5817625A (en) * 1992-09-21 1998-10-06 Oncogene Science, Inc. Methods of prevention of oral mucositis with transforming growth factor beta
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2162586C (en) * 1993-05-13 2006-01-03 David J. Grainger Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US6197789B1 (en) 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
WO1995009003A1 (en) * 1993-09-29 1995-04-06 Alcon Laboratories, Inc. Compositions containing growth factors and antimetabolites
US5411940A (en) * 1993-09-29 1995-05-02 Alcon Laboratories, Inc. Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma
US5449671A (en) * 1993-09-29 1995-09-12 Alcon Laboratories, Inc. Use of TGF-β3, to prevent or retard fistula closure following glaucoma filtration surgery
WO1995009004A1 (en) * 1993-09-29 1995-04-06 Alcon Laboratories, Inc. Compositions containing growth factors and antiplastic agents
AU2275395A (en) * 1994-03-31 1995-10-23 Biomedical Explorations, Llc Therapeutic homeopathic dilutions of growth factors and methods of their use
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
ATE493141T1 (en) 1996-03-22 2011-01-15 Stryker Corp METHOD FOR IMPROVED FUNCTIONAL RECOVERY OF MOTOR COORDINATION, LANGUAGE OR SENSORY PERCEPTION AFTER CNS TRAUMA OR ISCHEMIA
AU5593398A (en) * 1996-12-05 1998-06-29 Alcon Laboratories, Inc. The use of inhibitors of tgf-beta's functions to ameliorate ocular pathology
AU6959898A (en) 1997-04-11 1998-11-11 David J. Grainger Compounds and therapies for the prevention of vascular and non-vascular pathol ogies
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) * 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
EP1256316A1 (en) 2001-05-07 2002-11-13 Move2Health B.V. Portable device comprising an acceleration sensor and method of generating instructions or advice
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
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US10583220B2 (en) * 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7316822B2 (en) * 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) * 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US11395865B2 (en) * 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8657881B2 (en) * 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8221780B2 (en) * 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US7373820B1 (en) 2004-11-23 2008-05-20 James Terry L Accelerometer for data collection and communication
US8376984B2 (en) * 2005-07-14 2013-02-19 Terry L. James Apparatus, system, and method to deliver optimal elements in order to enhance the aesthetic appearance of the skin
US20080306762A1 (en) * 2007-06-08 2008-12-11 James Terry L System and Method for Managing Absenteeism in an Employee Environment
US20090048493A1 (en) * 2007-08-17 2009-02-19 James Terry L Health and Entertainment Device for Collecting, Converting, Displaying and Communicating Data
EP2591789B2 (en) * 2007-09-19 2022-07-20 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
US7676332B2 (en) * 2007-12-27 2010-03-09 Kersh Risk Management, Inc. System and method for processing raw activity energy expenditure data
US20090204422A1 (en) * 2008-02-12 2009-08-13 James Terry L System and Method for Remotely Updating a Health Station
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375127A1 (en) * 1988-11-02 1990-06-27 Genentech, Inc. Composition for the treatment of periodontal disease
WO1991000103A1 (en) * 1989-06-29 1991-01-10 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375127A1 (en) * 1988-11-02 1990-06-27 Genentech, Inc. Composition for the treatment of periodontal disease
WO1991000103A1 (en) * 1989-06-29 1991-01-10 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANNALS OF SURGERY, vol. 211, no. 3, March 1990, pages 288-294, L.B. Lippincott Co., (Philadelphia, PA, US), G.A. KSANDER et al.: "Exogenous transforming growth factor-beta 2 enhances connective tissue formation and wound strenght in Guinea pig dermal wounds healing by secondary intent" (L documents have been cited according to rule 33.3(b) of the Patent Corp. treaty, covering the entire subject matter to which the claims might reasonably be expected to be directed after they have been amended) *
SCIENCE, vol. 219, 18 March 1983, pages 1329-1331, M.B. SPORN et al.: "Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo" (cited in the application) (L documents have been cited according to rule 33.3(b) of the Patent Corp. treaty, covering the entire subject matter to which the claims might reasonably be expected to be directed after they have been amended) *
SCIENCE, vol. 237, 11 September 1987, pages 1333-1336, T.A. MUSTOE et al.: "Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta" (cited in the application) (L documents have been cited according to rule 33.3(b) of the Patent Corp. treaty, covering the entire subject matter to which the claims might reasonably be expected to be directed after they have been amended) *
THE JOURNAL OF CELL BIOLOGY, vol. 109, July 1989, pages 429-440, The Rockefeller University Press, G.F. PIERCE et al.: "Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms" (L documents have been cited according to rule 33.3(b) of the Patent Corp. treaty, covering the entire subject matter to which the claims might reasonably be expected to be directed after they have been amended) *

Also Published As

Publication number Publication date
ES2052378T3 (en) 1994-07-01
US5108989A (en) 1992-04-28
ATE102043T1 (en) 1994-03-15
EP0527787A1 (en) 1993-02-24
WO1991015222A2 (en) 1991-10-17
CA2078547A1 (en) 1991-10-05
EP0527787B1 (en) 1994-03-02
DE69101316D1 (en) 1994-04-07
DE69101316T2 (en) 1994-08-11
JPH05506030A (en) 1993-09-02
DK0527787T3 (en) 1994-08-22

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