WO1992014476A1 - Method of treating pulmonary inflammation - Google Patents
Method of treating pulmonary inflammation Download PDFInfo
- Publication number
- WO1992014476A1 WO1992014476A1 PCT/US1992/001398 US9201398W WO9214476A1 WO 1992014476 A1 WO1992014476 A1 WO 1992014476A1 US 9201398 W US9201398 W US 9201398W WO 9214476 A1 WO9214476 A1 WO 9214476A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rapamycin
- mammal
- comprises administering
- qaim
- pharmaceutical composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 15
- 206010035664 Pneumonia Diseases 0.000 title claims abstract description 12
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims abstract description 25
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims abstract description 25
- 229960002930 sirolimus Drugs 0.000 claims abstract description 25
- 208000006673 asthma Diseases 0.000 claims abstract description 11
- 241000124008 Mammalia Species 0.000 claims abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims abstract description 5
- 206010014561 Emphysema Diseases 0.000 claims abstract description 5
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims abstract description 5
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims abstract description 5
- 206010006451 bronchitis Diseases 0.000 claims abstract description 5
- 239000003085 diluting agent Substances 0.000 claims abstract description 4
- 239000003937 drug carrier Substances 0.000 claims abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 3
- 230000008569 process Effects 0.000 claims abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 210000004969 inflammatory cell Anatomy 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 5
- 230000004941 influx Effects 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000700198 Cavia Species 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 201000009961 allergic asthma Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000011597 hartley guinea pig Methods 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
- 229960000582 mepyramine Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 150000005671 trienes Chemical class 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU15356/92A AU662735B2 (en) | 1991-02-22 | 1992-02-21 | Method of treating pulmonary inflammation |
KR1019930702483A KR100201516B1 (en) | 1991-02-22 | 1992-02-21 | Pharmaceutical compositions for treating pulmonary inflammation containing ripamycin |
JP4507353A JP2673168B2 (en) | 1991-02-22 | 1992-02-21 | Pharmaceutical composition for preventing or improving inflammatory response in lung |
DE69229858T DE69229858T2 (en) | 1991-02-22 | 1992-02-21 | METHOD FOR TREATING INFLAMMATION OF THE LUNG |
CA002103571A CA2103571C (en) | 1991-02-22 | 1992-02-21 | Method of treating pulmonary inflammation |
EP92907905A EP0573584B1 (en) | 1991-02-22 | 1992-02-21 | Method of treating pulmonary inflammation |
DK92907905T DK0573584T3 (en) | 1991-02-22 | 1992-02-21 | Method of treating pneumonia |
HK98112290A HK1011284A1 (en) | 1991-02-22 | 1998-11-24 | Method of treating pulmonary inflammation |
GR990402771T GR3031681T3 (en) | 1991-02-22 | 1999-10-27 | Method of treating pulmonary inflammation. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/659,782 US5080899A (en) | 1991-02-22 | 1991-02-22 | Method of treating pulmonary inflammation |
US659,782 | 1991-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992014476A1 true WO1992014476A1 (en) | 1992-09-03 |
Family
ID=24646823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/001398 WO1992014476A1 (en) | 1991-02-22 | 1992-02-21 | Method of treating pulmonary inflammation |
Country Status (21)
Country | Link |
---|---|
US (1) | US5080899A (en) |
EP (1) | EP0573584B1 (en) |
JP (1) | JP2673168B2 (en) |
KR (1) | KR100201516B1 (en) |
AT (1) | ATE183647T1 (en) |
AU (1) | AU662735B2 (en) |
CA (1) | CA2103571C (en) |
DE (1) | DE69229858T2 (en) |
DK (1) | DK0573584T3 (en) |
ES (1) | ES2135404T3 (en) |
GR (1) | GR3031681T3 (en) |
HK (1) | HK1011284A1 (en) |
HU (1) | HUT70146A (en) |
IE (1) | IE920554A1 (en) |
IL (1) | IL100905A (en) |
LV (1) | LV12400B (en) |
NZ (1) | NZ241672A (en) |
PT (1) | PT100144B (en) |
SG (1) | SG52403A1 (en) |
WO (1) | WO1992014476A1 (en) |
ZA (1) | ZA921211B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2583678A2 (en) | 2004-06-24 | 2013-04-24 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206018A (en) * | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
US5221670A (en) * | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
US5358944A (en) * | 1990-09-19 | 1994-10-25 | American Home Products Corporation | Rapamycin esters for treating transplantation rejection |
US5378696A (en) * | 1990-09-19 | 1995-01-03 | American Home Products Corporation | Rapamycin esters |
US5321009A (en) * | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
US5194447A (en) * | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
US5286731A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
US5286730A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
US5164399A (en) * | 1991-11-18 | 1992-11-17 | American Home Products Corporation | Rapamycin pyrazoles |
US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
US5262424A (en) * | 1992-02-18 | 1993-11-16 | American Home Products Corporation | Composition of sulfonylcarbamates of rapamycin and method of treating diseases requiring immunosuppression therewith |
US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
ES2089723T3 (en) | 1992-03-27 | 1996-10-01 | American Home Prod | 29-DEMETOXIRAPAMICINA TO INDUCE IMMUNODEPRESSION. |
US5288711A (en) * | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
US5256790A (en) * | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
CA2106034A1 (en) * | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
US5434260A (en) * | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
US5480989A (en) * | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5489680A (en) * | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
US5480988A (en) * | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
US5262423A (en) * | 1992-10-29 | 1993-11-16 | American Home Products Corporation | Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents |
US5260300A (en) * | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
US5349060A (en) * | 1993-01-07 | 1994-09-20 | American Home Products Corporation | Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents |
US5252579A (en) * | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
JPH08509499A (en) | 1993-04-23 | 1996-10-08 | アボツト・ラボラトリーズ | Rapamycin conjugates and antibodies |
US5504091A (en) * | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
US5387680A (en) * | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
IL111004A (en) * | 1993-09-30 | 1998-06-15 | American Home Prod | Oral rapamycin formulations |
US5536729A (en) * | 1993-09-30 | 1996-07-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
US5516770A (en) * | 1993-09-30 | 1996-05-14 | American Home Products Corporation | Rapamycin formulation for IV injection |
US5616588A (en) * | 1993-09-30 | 1997-04-01 | American Home Products Corporation | Rapamycin formulation for IV injection |
US5373014A (en) * | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5391730A (en) * | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
US5385909A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
US5385910A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
US5385908A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
US5389639A (en) * | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
US5525610A (en) * | 1994-03-31 | 1996-06-11 | American Home Products Corporation | 42-Epi-rapamycin and pharmaceutical compositions thereof |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5463048A (en) * | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
US5491231A (en) * | 1994-11-28 | 1996-02-13 | American Home Products Corporation | Hindered N-oxide esters of rapamycin |
US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US5496832A (en) * | 1995-03-09 | 1996-03-05 | American Home Products Corporation | Method of treating cardiac inflammatory disease |
US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
IT1289815B1 (en) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS |
IL135774A0 (en) * | 1997-10-22 | 2001-05-20 | Ponikau Jens | Use of antinfungal agents for the topical treatment of fungus-induced mucositis |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
WO2002024706A2 (en) | 2000-09-19 | 2002-03-28 | Wyeth | Water soluble rapamycin esters |
US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
US6923927B2 (en) * | 2000-10-03 | 2005-08-02 | Atrium Medical Corporation | Method for forming expandable polymers having drugs or agents included therewith |
TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
TWI296196B (en) * | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
US20020198137A1 (en) * | 2001-06-01 | 2002-12-26 | Wyeth | Antineoplastic combinations |
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
US6680330B2 (en) | 2001-08-22 | 2004-01-20 | Wyeth | Rapamycin dialdehydes |
BR0211986A (en) | 2001-08-22 | 2004-09-28 | Wyeth Corp | Rapamycin 29-enols |
WO2003043570A2 (en) | 2001-11-15 | 2003-05-30 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
PT1553940E (en) | 2002-07-30 | 2008-05-09 | Wyeth Corp | Parenteral formulations containing a rapamycin hydroxyester |
MXPA05002828A (en) * | 2002-09-17 | 2005-05-27 | Wyeth Corp | Oral formulations. |
AR042938A1 (en) * | 2003-02-06 | 2005-07-06 | Wyeth Corp | USE OF CCI-779 IN THE TREATMENT OF HEPATIC FIBROSIS |
UA83484C2 (en) * | 2003-03-05 | 2008-07-25 | Уайт | Method for treating breast cancer using combination of rapamycin derivative and aromatase inhibitor, pharmaceutical composition |
RU2005136222A (en) * | 2003-04-22 | 2006-03-20 | Уайт (Us) | ANTI-TUMOR COMBINATIONS |
US20040236410A1 (en) * | 2003-05-22 | 2004-11-25 | Atrium Medical Corp. | Polymeric body formation |
US20040236279A1 (en) * | 2003-05-22 | 2004-11-25 | Atrium Medical Corp. | Gaseous therapeutic agent delivery |
US20040236278A1 (en) * | 2003-05-22 | 2004-11-25 | Atrium Medical Corp. | Therapeutic agent delivery |
US20040253185A1 (en) * | 2003-06-12 | 2004-12-16 | Atrium Medical Corp. | Medicated ink |
JP2007532655A (en) * | 2004-04-14 | 2007-11-15 | ワイス | Process for preparing rapamycin 42-ester with dicarboxylic acid and FK-50632-ester with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
MX2007003789A (en) * | 2004-10-04 | 2007-07-20 | Qlt Usa Inc | Ocular delivery of polymeric delivery formulations. |
EP2662082A1 (en) | 2005-11-14 | 2013-11-13 | Ariad Pharmaceuticals, Incorporated | Administration of mTOR inhibitors |
WO2008022256A2 (en) * | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
US20110034503A1 (en) * | 2006-08-22 | 2011-02-10 | Ruey-Shiuan Tsai | Rapamycin and its derivatives for the treatment of liver-associated fibrosing disorders |
BRPI0716950A2 (en) | 2006-09-13 | 2013-10-29 | Elixir Medical Corp | PHARMACEUTICAL COMPOSITION, INTRACORPOSE DEVICE, METHOD FOR INHIBITING CELL, COMPOUND PROLIFERATION, AND METHOD FOR PREPARING A COMPOUND |
US8414526B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) * | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
EP2086602A2 (en) * | 2006-11-20 | 2009-08-12 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
EP2280995A2 (en) * | 2008-04-29 | 2011-02-09 | Wyeth LLC | Methods for treating inflammation |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
CA2743491C (en) | 2008-11-11 | 2016-10-11 | Zelton Dave Sharp | Inhibition of mammalian target of rapamycin |
AU2010233073B2 (en) | 2009-04-10 | 2014-07-31 | Haiyan Qi | Novel anti-aging agents and methods to identify them |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
EP2906214A1 (en) | 2012-10-12 | 2015-08-19 | The Board of Regents of The University of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
CN106061482A (en) | 2013-10-08 | 2016-10-26 | 拉姆医疗公司 | Rapamycin for the treatment of lymphangioleiomyomatosis |
AU2014373683B2 (en) | 2013-12-31 | 2020-05-07 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
RU2016136348A (en) * | 2014-02-11 | 2018-03-16 | Лэм Терапьютикс, Инк. | RAPAMYCIN FOR TREATMENT OF LYMPHNANGIOLEIOMYOMATOSIS |
US10307371B2 (en) | 2014-02-11 | 2019-06-04 | AI Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
NZ724756A (en) | 2014-04-04 | 2023-07-28 | Ai Therapeutics Inc | An inhalable rapamycin formulation for treating age-related conditions |
US10328045B2 (en) | 2014-09-12 | 2019-06-25 | Children's Medical Center Corporation, Inc. | Dietary emulsion formulations and methods for using the same |
BR112017006842A2 (en) | 2014-10-07 | 2017-12-12 | Lam Therapeutics Inc | Inhalable rapamycin formulation for the treatment of pulmonary hypertension |
WO2016066608A1 (en) * | 2014-10-28 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging |
MA40910A (en) | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | RAPAMYCIN POWDERS FOR PULMONARY ADMINISTRATION |
WO2016130645A1 (en) | 2015-02-10 | 2016-08-18 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929992A (en) * | 1972-09-29 | 1975-12-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023264A (en) * | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
WO1992008474A2 (en) * | 1990-11-20 | 1992-05-29 | The National Heart & Lung Institute | Treatment of lung diseases |
-
1991
- 1991-02-22 US US07/659,782 patent/US5080899A/en not_active Expired - Lifetime
-
1992
- 1992-02-10 IL IL10090592A patent/IL100905A/en not_active IP Right Cessation
- 1992-02-19 ZA ZA921211A patent/ZA921211B/en unknown
- 1992-02-20 NZ NZ241672A patent/NZ241672A/en not_active IP Right Cessation
- 1992-02-20 PT PT100144A patent/PT100144B/en not_active IP Right Cessation
- 1992-02-21 CA CA002103571A patent/CA2103571C/en not_active Expired - Fee Related
- 1992-02-21 DK DK92907905T patent/DK0573584T3/en active
- 1992-02-21 KR KR1019930702483A patent/KR100201516B1/en not_active IP Right Cessation
- 1992-02-21 WO PCT/US1992/001398 patent/WO1992014476A1/en active IP Right Grant
- 1992-02-21 DE DE69229858T patent/DE69229858T2/en not_active Expired - Fee Related
- 1992-02-21 IE IE055492A patent/IE920554A1/en not_active IP Right Cessation
- 1992-02-21 AU AU15356/92A patent/AU662735B2/en not_active Ceased
- 1992-02-21 ES ES92907905T patent/ES2135404T3/en not_active Expired - Lifetime
- 1992-02-21 JP JP4507353A patent/JP2673168B2/en not_active Expired - Fee Related
- 1992-02-21 EP EP92907905A patent/EP0573584B1/en not_active Expired - Lifetime
- 1992-02-21 AT AT92907905T patent/ATE183647T1/en not_active IP Right Cessation
- 1992-02-21 SG SG1996004019A patent/SG52403A1/en unknown
- 1992-02-21 HU HU9302376A patent/HUT70146A/en unknown
-
1998
- 1998-11-24 HK HK98112290A patent/HK1011284A1/en not_active IP Right Cessation
-
1999
- 1999-10-21 LV LVP-99-149A patent/LV12400B/en unknown
- 1999-10-27 GR GR990402771T patent/GR3031681T3/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929992A (en) * | 1972-09-29 | 1975-12-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2583678A2 (en) | 2004-06-24 | 2013-04-24 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
Also Published As
Publication number | Publication date |
---|---|
IL100905A0 (en) | 1992-11-15 |
DK0573584T3 (en) | 1999-12-13 |
SG52403A1 (en) | 1998-09-28 |
HK1011284A1 (en) | 1999-07-09 |
LV12400B (en) | 2000-07-20 |
ZA921211B (en) | 1993-08-19 |
PT100144A (en) | 1993-08-31 |
JP2673168B2 (en) | 1997-11-05 |
IE920554A1 (en) | 1992-08-26 |
PT100144B (en) | 1999-06-30 |
KR100201516B1 (en) | 1999-06-15 |
ATE183647T1 (en) | 1999-09-15 |
US5080899A (en) | 1992-01-14 |
EP0573584B1 (en) | 1999-08-25 |
EP0573584A4 (en) | 1994-02-16 |
DE69229858D1 (en) | 1999-09-30 |
EP0573584A1 (en) | 1993-12-15 |
DE69229858T2 (en) | 1999-12-09 |
IL100905A (en) | 1995-11-27 |
KR930703000A (en) | 1993-11-29 |
ES2135404T3 (en) | 1999-11-01 |
AU662735B2 (en) | 1995-09-14 |
GR3031681T3 (en) | 2000-02-29 |
CA2103571C (en) | 2003-04-29 |
HUT70146A (en) | 1995-09-28 |
AU1535692A (en) | 1992-09-15 |
JPH06504790A (en) | 1994-06-02 |
CA2103571A1 (en) | 1992-08-23 |
LV12400A (en) | 1999-12-20 |
NZ241672A (en) | 1997-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU662735B2 (en) | Method of treating pulmonary inflammation | |
AU664354B2 (en) | Treatment of organ transplantation rejection | |
EP1628682B1 (en) | Composition comprising a pde4 inhibitor and a pde5 inhibitor for the treatment of copd | |
EP1278528A1 (en) | Nucleoside analogs with carboxamidine-modified bicyclic base | |
AU2005249231A1 (en) | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases | |
JPH05170771A (en) | Medicinal composition for treatment of adul t cell leukemia/lymphoma | |
JP2001523228A (en) | Nucleophilic substituted ecteinascidins and N-oxide ecteinascidins | |
EP1450803A1 (en) | New uses for anti-malarial therapeutic agents | |
JPH06157344A (en) | Preparation for blocking new formation of blood vessel and method of blocking new formation of blood vessel | |
EP0562853B1 (en) | 29-Demethoxyrapamycin for inducing immunosuppression | |
CA2270373A1 (en) | Synergistic composition comprising rapamycin and calcitriol | |
JP2003518134A (en) | Treatment of viral infection with Levovirin ™ | |
JPH10502058A (en) | Aryl, alkyl, alkenyl and alkynyl macrolides | |
JPH02209808A (en) | Treating method of matter addiction | |
Morton et al. | Corticosteroids and malnutrition: Aspergillus lung abscess in an asthmatic child | |
Ruffie et al. | Modulation of the bronchial inflammation in sensitized guinea-pigs by FK506, nedocromil sodium and dexamethasone | |
JPH10251159A (en) | Medicine for decreasing serum uric acid value, containing il-6 | |
WO1993014771A1 (en) | Macrocyclic compounds in the prophylactic treatment of aids | |
RU2356555C2 (en) | Antineutrophilic agent | |
WO2001052860A2 (en) | Method and composition for modulating an immune response | |
JPS59167516A (en) | Antiallergic agent | |
Ziment | Chest Diseases—Important Advances in Clinical Medicine: Adverse Drug Interactions With Theophylline | |
Fukuoka et al. | CLINICAL EVALUATION OF CPT-11, A TOPOISOMERASE I INHIBITOR, IN LUNG CANCER | |
WO2005110450A1 (en) | Medicinal composition and therapeutic method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU CA HU JP KR |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
EX32 | Extension under rule 32 effected after completion of technical preparation for international publication | ||
LE32 | Later election for international application filed prior to expiration of 19th month from priority date or according to rule 32.2 (b) | ||
LE32 | Later election for international application filed prior to expiration of 19th month from priority date or according to rule 32.2 (b) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2103571 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1992907905 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1019930702483 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 1992907905 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1992907905 Country of ref document: EP |