WO1993004022A1 - Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer - Google Patents

Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer Download PDF

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Publication number
WO1993004022A1
WO1993004022A1 PCT/JP1992/001024 JP9201024W WO9304022A1 WO 1993004022 A1 WO1993004022 A1 WO 1993004022A1 JP 9201024 W JP9201024 W JP 9201024W WO 9304022 A1 WO9304022 A1 WO 9304022A1
Authority
WO
WIPO (PCT)
Prior art keywords
solvent
optical isomer
optical
reuse
port
Prior art date
Application number
PCT/JP1992/001024
Other languages
English (en)
French (fr)
Inventor
Masakazu Negawa
Fumihiko Shoji
Original Assignee
Daicel Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16591429&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1993004022(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daicel Chemical Industries, Ltd. filed Critical Daicel Chemical Industries, Ltd.
Priority to DE69223037T priority Critical patent/DE69223037T3/de
Priority to EP92916823A priority patent/EP0563388B2/en
Priority to US08/030,063 priority patent/US5434298A/en
Publication of WO1993004022A1 publication Critical patent/WO1993004022A1/ja
Priority to KR93701126A priority patent/KR960009561B1/ko
Priority to US08/202,970 priority patent/US5498752A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterized by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
PCT/JP1992/001024 1991-08-22 1992-08-10 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer WO1993004022A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69223037T DE69223037T3 (de) 1991-08-22 1992-08-10 Wiedergewinnung von optischen isomeren und lösungsmittel bei einer optischen auflösung, wiederbenutzung des lösungsmittels und optischen isomers nach recycling
EP92916823A EP0563388B2 (en) 1991-08-22 1992-08-10 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer
US08/030,063 US5434298A (en) 1991-08-22 1992-08-10 Process for recovering optical isomers and solvent, process for using solvent by circulation and process for reusing optical isomers in optical resolution
KR93701126A KR960009561B1 (en) 1991-08-22 1993-04-15 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer
US08/202,970 US5498752A (en) 1991-08-22 1994-02-28 Process for recovering optical isomers and solvent, process for using solvent by circulation and process for reusing optical isomers in optical resolution

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3210565A JP3010816B2 (ja) 1991-08-22 1991-08-22 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法
JP3/210565 1991-08-22

Publications (1)

Publication Number Publication Date
WO1993004022A1 true WO1993004022A1 (en) 1993-03-04

Family

ID=16591429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/001024 WO1993004022A1 (en) 1991-08-22 1992-08-10 Recovery of optical isomer and solvent in optical resolution, reuse of solvent by recycling, and reuse of optical isomer

Country Status (6)

Country Link
US (2) US5434298A (ja)
EP (2) EP0563388B2 (ja)
JP (1) JP3010816B2 (ja)
KR (1) KR960009561B1 (ja)
DE (2) DE69223037T3 (ja)
WO (1) WO1993004022A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO2005113101A2 (de) 2004-05-21 2005-12-01 Bayer Technology Services Gmbh Verfahren zur herstellung von chemischen und pharmazeutischen produkten mit integrierter mehrsäulen-chromatographie
CN104387237A (zh) * 2014-01-22 2015-03-04 江苏汉邦科技有限公司 模拟移动床色谱拆分4-氯二苯甲醇对映体的方法

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US5770088A (en) * 1992-06-30 1998-06-23 Daicel Chemical Industries, Ltd. Simulated moving bed chromatographic separation process
CN1136183C (zh) * 1994-02-25 2004-01-28 代科化学工业株式会社 光学活性甲羟戊酸内酯类化合物的制造方法
JPH07285889A (ja) * 1994-04-20 1995-10-31 Daicel Chem Ind Ltd 光学異性体の分離方法
JPH08176133A (ja) * 1994-12-26 1996-07-09 Takeda Chem Ind Ltd Ｌ−アスコルビン酸の精製法
US5626762A (en) * 1995-02-13 1997-05-06 Uop Separations by simulated moving bed chromatography operating at low K' values using weakly interating adsorbents as the stationary phase
US5518625A (en) * 1995-02-13 1996-05-21 Uop Chiral separations by simulated moving bed chromatography operating at low k' values
US5645729A (en) * 1995-02-13 1997-07-08 Uop Separations by simulated moving bed chromatography operating at low k' values using weakly interacting adsorbents as the stationary phase
IL115941A (en) * 1995-11-09 1998-10-30 Weizmann Kiryat Membrane Prod Multi-stage membrane system and process
FR2754731B1 (fr) * 1996-10-18 1999-07-02 Novasep Sa Perfectionnement aux procedes d'enrichissement d'isomeres optiques par lit mobile simule
JPH1190106A (ja) * 1997-09-26 1999-04-06 Daicel Chem Ind Ltd 擬似移動床式クロマト分離装置
AU6864798A (en) * 1998-03-16 1999-10-11 Chiral Technologies, Inc. Chiral separations of pyrimidines
WO1999057089A1 (en) * 1998-05-01 1999-11-11 Pfizer Products Inc. Process for the production of enantiomerically pure or optically enriched sertraline-tetralone using continuous chromatography
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
JP3453516B2 (ja) * 1998-05-29 2003-10-06 オルガノ株式会社 クロマト分離方法
DE19858892A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
EP1301519B2 (en) 2000-07-21 2021-11-10 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
CN100393411C (zh) 2000-10-13 2008-06-11 大赛璐化学工业株式会社 旋光异构体分离用填充剂及使用该剂的旋光异构体分离法
JP4873207B2 (ja) * 2001-02-26 2012-02-08 東レ・ファインケミカル株式会社 光学活性カルボン酸クロリドの精製方法
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
FR2836396B1 (fr) * 2002-02-22 2004-06-18 Novasep Procede et dispositif de chromatographie avec recuperation de solvant
JP2004003935A (ja) * 2002-04-12 2004-01-08 Daicel Chem Ind Ltd 擬似移動床式クロマトグラフィー用光学異性体分離用充填剤
FR2846252B1 (fr) * 2002-10-29 2005-07-01 Novasep Procede et dispositif de chromatographie integrant une etape de concentration
US20060128955A1 (en) * 2003-05-09 2006-06-15 Vela Pharmaceuticals, Inc. Method of isolating (R)-tofisopam
GB0325055D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
EP1773793A2 (en) * 2004-07-03 2007-04-18 Merck Generics (UK) Limited Process for the preparation of pramipexole by chiral chromatography
DE602004031387D1 (de) * 2004-12-20 2011-03-24 Sk Holdings Co Ltd Verfahren zur trennung von optisch reinen thiophenverbindungen unter anwendung von simulierter bewegtbettchromatographie
FR2889077B1 (fr) * 2005-07-26 2007-10-12 Novasep Soc Par Actions Simpli Procede et dispositif de separation chromatographique de fractions d'un melange
JP2007085829A (ja) * 2005-09-21 2007-04-05 Daicel Chem Ind Ltd 近赤外分光分析装置を校正するための装置及び方法
HU226863B1 (en) * 2005-12-09 2009-12-28 Chinoin Gyogyszer Es Vegyeszet Process for separation of optical isomers of "corey-lactone" by liquid chromatography
KR100741752B1 (ko) * 2005-12-26 2007-07-23 삼성토탈 주식회사 단일 흡착 챔버를 사용하여 공급물을 전처리하는 유사 이동층 흡착 분리 방법 및 그에 사용되는 장치
US20080314835A1 (en) * 2007-01-16 2008-12-25 Regina Valluzzi Chiral separating agents with active support
US7618539B2 (en) 2008-03-31 2009-11-17 Ampac Fine Chemicals Llc Simulated moving bed chromatography for strongly retained compounds
WO2013156630A1 (en) 2012-04-20 2013-10-24 Alphaptose Gmbh S-enantiomer of a tri-substituted glycerol compound
EP2801604B1 (en) 2013-05-07 2017-04-12 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids

Citations (2)

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Publication number Priority date Publication date Assignee Title
JPS5376165A (en) * 1976-12-18 1978-07-06 Tanabe Seiyaku Co Ltd Continuous optical resolving method and apparatus for organic racemic compoung
JPS61122226A (ja) * 1984-11-17 1986-06-10 ラポート・インダストリーズ・リミテッド ラセミ体の分割方法

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US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
FR2593409B1 (fr) * 1986-01-30 1990-08-24 Centre Nat Rech Scient Procede de separation des constituants d'un melange comprenant au moins deux composes connus pour etre difficiles a separer et faisant appel au phenomene d'adsorption
JPS62210053A (ja) * 1986-03-07 1987-09-16 Agency Of Ind Science & Technol 光学異性体分離用充填剤
JP2925753B2 (ja) † 1990-02-23 1999-07-28 ダイセル化学工業株式会社 光学異性体の分離方法
US5220053A (en) * 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5376165A (en) * 1976-12-18 1978-07-06 Tanabe Seiyaku Co Ltd Continuous optical resolving method and apparatus for organic racemic compoung
JPS61122226A (ja) * 1984-11-17 1986-06-10 ラポート・インダストリーズ・リミテッド ラセミ体の分割方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0563388A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005113101A2 (de) 2004-05-21 2005-12-01 Bayer Technology Services Gmbh Verfahren zur herstellung von chemischen und pharmazeutischen produkten mit integrierter mehrsäulen-chromatographie
US7615159B2 (en) 2004-05-21 2009-11-10 Bayer Technology Services Gmbh Method for the production of chemical and pharmaceutical products with integrated multicolumn chromatography
EP2336617A2 (de) 2004-05-21 2011-06-22 Bayer Technology Services GmbH Verfahren zur Herstellung von chemischen und pharmazeutischen Produkten mit integrierter Mehrsäulen-Chromatographie
US8658040B2 (en) 2004-05-21 2014-02-25 Bayer Intellectual Property Gmbh Modular valve system for countercurrent chromatography process
CN104387237A (zh) * 2014-01-22 2015-03-04 江苏汉邦科技有限公司 模拟移动床色谱拆分4-氯二苯甲醇对映体的方法

Also Published As

Publication number Publication date
EP0563388A1 (en) 1993-10-06
US5434298A (en) 1995-07-18
KR960009561B1 (en) 1996-07-20
DE69223037T3 (de) 2001-08-02
EP0563388A4 (en) 1994-07-06
DE69223037T2 (de) 1998-02-26
EP0563388B1 (en) 1997-11-05
KR930702252A (ko) 1993-09-08
DE69233679T2 (de) 2007-06-14
EP0719749A2 (en) 1996-07-03
DE69233679D1 (de) 2007-03-29
DE69223037D1 (de) 1997-12-11
EP0563388B2 (en) 2001-04-04
US5434299A (en) 1995-07-18
JP3010816B2 (ja) 2000-02-21
JPH06239767A (ja) 1994-08-30
EP0719749B1 (en) 2007-02-14
EP0719749A3 (en) 1996-07-17

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