WO1993004728A1 - Selective aortic perfusion system - Google Patents
Selective aortic perfusion system Download PDFInfo
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- WO1993004728A1 WO1993004728A1 PCT/US1992/007605 US9207605W WO9304728A1 WO 1993004728 A1 WO1993004728 A1 WO 1993004728A1 US 9207605 W US9207605 W US 9207605W WO 9304728 A1 WO9304728 A1 WO 9304728A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
- A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
- A61B50/33—Trays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/002—Packages specially adapted therefor ; catheter kit packages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
- A61M60/139—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting inside the aorta, e.g. intra-aortic balloon pumps
-
- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/295—Balloon pumps for circulatory assistance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/31—Medical purposes thereof other than the enhancement of the cardiac output for enhancement of in vivo organ perfusion, e.g. retroperfusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/38—Blood oxygenation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/497—Details relating to driving for balloon pumps for circulatory assistance
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/515—Regulation using real-time patient data
- A61M60/531—Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
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- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/833—Occluders for preventing backflow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0001—Catheters; Hollow probes for pressure measurement
- A61M2025/0002—Catheters; Hollow probes for pressure measurement with a pressure sensor at the distal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1059—Balloon catheters with special features or adapted for special applications having different inflatable sections mainly depending on the response to the inflation pressure, e.g. due to different material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1072—Balloon catheters with special features or adapted for special applications having balloons with two or more compartments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0476—Oxygenated solutions
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/06—Packaging for specific medical equipment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
Definitions
- the present invention relates generally to treatment of a patient during cardiopulmonary resuscita- tion (CPR) and more particularly to a process and appara ⁇ tus for aortic occlusion along with oxygen carrying fluid infusion for use during CPR.
- CPR cardiopulmonary resuscita- tion
- Cardiopulmonary resuscitation has not fulfilled its original expectations, and the prognosis for patients remaining in cardiac arrest more than ten minutes remains poor (Becker AB, Ann Emerg Med, 20:355 (1991)). Indeed, cardiopulmonary resuscitation has recently been termed a "spectacular failure" in which only a small minority of patients have been successfully resuscitated (Barsan G, JAMA. 265:3115-3118 (1991)). Standard advanced cardiac life support (AC S) has only limited efficacy after the first few minutes of cardiac arrest.
- Aortic counterpulsation may improve perfusion (Emerman CL, et al, Am J Emercr Med. 7:378-383 (1989)), but has the disadvantage of requiring complex equipment which limits its use. Simple balloon occlusion, with or without volume infusion, does not appear to be effective.
- An oxygenated fluid (such as either oxygenated fluorocarbons or stroma- free polyhemoglobin) is used as the infused fluid either in a pre-oxygenated state or after an oxygenator has oxygenated the fluid.
- Aortic occlusion with oxygen-carrying fluid infusion will significantly improve oxygen supply for short periods of time to the heart and brain.
- the infu ⁇ sion of oxygen-carrying fluid will be retrograde up the descending aorta toward the head resulting in preferential infusion of the coronary and carotid arteries. Attempts at defibrillation after this period of improved perfusion of the cardiac muscle will result in significantly higher rates of return of spontaneous circulation when compared to standard CPR.
- Placement of a balloon catheter in the de ⁇ scending aorta through the femoral artery is not difficult (Bregman D, et al, Am J Cardiol. 46:261-264 (1980)) and it may be possible to accomplish this even in a prehospital setting.
- the catheter which is used for the present invention is specially designed so as to have a large infusion port.
- Known balloon catheters have an infusion lumen which is relatively small, designed for the delivery of drugs or small amounts of fluid or for measurement of blood pressure.
- the catheter of the present invention must be designed to permit the flow of large amounts of perfusion fluid.
- the present invention further comprehends a kit for use in performing the process of the present inven ⁇ tion, which kit will include a catheter, a supply of stroma-free polyhemoglobin (or other oxygen-carrying perfusion fluid) and, optionally, an oxygenator to cause oxygenation of the fluid prior to perfusion through the catheter.
- kit will preferably also include all of the other paraphernalia for carrying out the process of the present invention.
- Fig. l is a schematic representative cross- section of a balloon catheter which can be used in accor ⁇ dance with the present invention
- Fig. 2 is a schematic representative cross- section of a pressurizable container for use in dispensing oxygenatable fluid
- Fig. 3 is a schematic representative cross- section of an oxygenating system for use with the present invention.
- Fig. 4 is a diagrammatic representation of a kit in accordance with the present invention
- Fig. 5 is a diagrammatic representation showing the catheter in appropriate position during use.
- the selective aortic perfusion system of the present invention has three major components.
- the first is a specially constructed balloon catheter 12 as shown in Fig. 1.
- This catheter is sized and dimensioned to permit insertion through the femoral artery and feeding up into the aorta until the balloon 14 is located in the de ⁇ scending aorta.
- the medical or paramedical personnel using this invention in an emergency setting will know when the balloon is in appropriate position when the tip of the catheter impacts the top of the aortic arch and cannot easily be maneuvered further through the aorta.
- the catheter 12 will include markings 22, 24 which signal the distance from the marking to the tip 20 of the catheter 12.
- a double mark 24 m y mean that the distal tip is 70 cm away with each single mark 22 being in 2 cm increments.
- the person inserting the catheter 12 will know the position of the balloon 14 in the aorta from a consideration of the mark ⁇ ings at the proximal end of the catheter.
- the bal- loon 14 When the bal- loon 14 is in position and is inflated, it will occlude the aorta above the level of the diaphragm (see Fig. 5) .
- infused fluids will be restricted only to the volume of the aorta and associated arteries above the balloon occlusion.
- the catheter 12 is constructed to have two lumens 16, 18. The smaller lumen 16 is used for inflating the balloon.
- This lumen 16 can be attached to, for exam ⁇ ple, a 30 cc syringe (not shown) filled with saline. In the rare event of a balloon failure, only saline fluid would be released into the aorta.
- the larger lumen 18 opens distal to the balloon 18 at a point 20 and is at ⁇ tached to the system for infusion of oxygen containing fluid.
- the lumens 16, 18 may be side by side or coaxial.
- the larger lumen 18 distinguishes the catheter of the present invention from all prior art balloon cathe ⁇ ters.
- the cross-section of this lumen must be large enough to permit sufficient infusion of oxygenated fluid to oxygenate the myocardium and the cerebrum.
- the appropriate size lumen to permit this much infusion over the specified time period can be designed using standard engineering formulas, such as Poiseuille's Law, and/or empirical testing.
- the optimum diameter is on the order of about 2-3 mm so as to permit infusion without using excessive feed pressure while maintaining the cathe- ter as a whole sufficiently small to permit insertion through the femoral artery. It is believed that the largest existing balloon catheters have an inner lumen of less than about 1 mm. For some applications, such as pediatric applications, the diameter may be as small as 1.5 mm and could be as large as 4 mm. Catheters of this large size can be easily placed using existing guide wire/introducer sheath techniques.
- the most important function of the oxygenated fluid is to perfuse the myocardium, thereby permitting a vastly improved chance of return to spontaneous circula ⁇ tion after defibrillation. It is a secondary function to oxygenate the brain in order to prevent damage to the brain during the period of cardiac arrest. However, a prompt return to spontaneous circulation after perfusion of the myocardium and defibrillation will serve the pur ⁇ pose of oxygenating the cerebrum much better than the perfusion of oxygenated fluid in accordance with the present invention. In order to increase the amount of perfusion of the myocardium and cerebrum, it may be desir ⁇ able to actually prevent flow of the perfusion fluid to the upper extremities by applying pressure to the appro- priate arteries during infusion of the fluid.
- the second component of the system of the pres ⁇ ent invention is oxygenated fluid.
- oxygenated fluid there are two types of artificial fluids which are used to carry oxygen for use in humans. The first is oxygenated fluoro ⁇ carbons and the second is stroma-free polyhemoglobin.
- SFPH Stroma-free polyhemoglobin
- the stroma-free polyhemoglobin solution is preferably packaged in a special container capable of being pressurized, as shown in Fig. 2, so that it can be infused at pressures necessary to overcome those during the compression phase of CPR and necessary to provide a sufficient flow rate of oxygenating fluid.
- the stroma- free polyhemoglobin is stored in a pressure bag 32, pref ⁇ erably in a quantity of 500 cc or more.
- the bag is placed in a container 30 having a lid.31 sealed thereto.
- An inlet valve 34 in the lid 31 of the container includes a regulator mechanism (the details of which are well known and not shown) which permits entry of pressurized fluid at a specified maximum pressure regardless of the pressure of the fluid at the inlet of the valve 34.
- the valve 34 includes an inlet nozzle 36 which is connectable to the source of standardized pressurized oxygen available in all emergency and critical care settings. While pressurized oxygen is the preferred source of pressurized fluid to drive the feeding of the oxygenating fluid, it is to be understood that any other source of pressurized gas or liquid could be used for this purpose.
- An outlet tube 37 connected to the interior of the bag 32 extends from the container 30 and includes a connector 38 for connection to the oxygenating fluid feeding lumen 18 of the catheter 12.
- the oxygenating solution may also include the simultaneous infusion of other drugs or agents to improve myocardial and cerebral outcome. Any agent demonstrated to be effective when given intravenously may be more effective when administered to the heart and brain selec ⁇ tively by means of the present invention. Tissue sal ⁇ vaging agents in particular may be included in the oxygenated infusion fluid.
- agents which may be included in the oxygenated infusion fluid of the pres ⁇ ent invention are:- epinephrine or other adrenergic agonists and pressors; antioxidants and free-radical scavengers such as the 21-amino steroids (lazaroids) ; anti-inflammatory agents including steroids and non-ste- roidal anti-inflammatory drugs such as a ibuprofen; calci ⁇ um channel blockers such as lidoflazine, nimodipine, nicardipine, flunarizine, etc.; excitatory neurotransmitter blockers (NMDA receptor agonists) such as MK801, etc.; anticoagulants such as heparin; iron and heavy metal chelators such as deferoxamine; osmotic agents such as mannitol; anti-acidosis agents such as bicarbonate or dichloroacetate; insulin; antibodies such as anti- neutrophile antibody; and allopurinol.
- the third component of the system of the present invention is an apparatus to oxygenate the stroma-free polyhemoglobin before infusion.
- This component is option ⁇ al as the SFPH may be supplied already oxygenated and ready to use. However, as the SFPH may lose its oxygen over storage time it is preferred that the fluid be fresh ⁇ ly oxygenated immediately prior to perfusion. Simple infusion of the solution into the arterial side of the circulation without pre-oxygenation would not improve the delivery of oxygen to the myocardium and brain. As shown in Fig.
- a hollow fiber membrane oxygenator 40 having hollow fibers 41 can be placed in the system between the pressurized container 30 of stroma-free polyhemoglobin, at in-port 42 and the lumen 18 of the balloon catheter 12 at out-port 44.
- These systems allow the blood to flow around numerous hollow fibers 41 which have been specially con ⁇ structed to allow diffusion of gas phase components with ⁇ out leakage of hemoglobin or blood.
- Oxygen is forced in at in-port 46 and exits at out-port 48.
- the mechanism of oxygenation is preferably countercurrent, which should result in oxygenation of the stroma-free polyhemoglobin, or other oxygenating fluid, to its maximum saturation.
- This device will also be constructed so that standard oxygen tanks or other emergency room oxygen supply can be used to supply it.
- the same oxygen can be used to inflate the pressure bag and drive the infusion as is used to oxygenate the fluid.
- the components of the present invention are preferably packaged in kit form for use by medical and paramedical personnel. As shown in Fig. 4, the components may be packaged in a container 50, preferably a rigid plastic material molded to provide compartments for the various components of the kit. Compartment 52 holds the catheter 12, compartment 54 holds the container 30 with the sack 32 of stroma-free polyhemoglobin (or compartment 54 may comprise the container 30 and hold only the sack 32), and compartment 56 holds the oxygenator 40. Compart- ments for other paraphernalia necessary to implement the process of the present invention may also be present.
- compartment 58 may be present for holding a syringe 60 to be used for inflation of the balloon and compartment 62 may be present to hold a catheter insertion sheath 64.
- Other components such as oxygenation tubing, guide wires, instructions for use, etc., may also be present.
- the preferred kit form for use in the present invention is one which is the simplest and easiest to use in an emergency situation, which is often somewhat chaot ⁇ ic.
- the connections between the oxygenator and the source of stroma-free hemoglobin may be built-in so that the source of oxygenating fluid and the oxygenator need never be removed from the kit.
- the connection between the oxygen output of the oxygenator and the pres ⁇ sure chamber of the oxygenating fluid compartment may be built into the kit, as may the connection between the balloon syringe and the catheter lumen leading to the balloon and the connection between the oxygenator fluid output and the catheter lumen for feeding the oxygenated fluid.
- the oxygenator may be built into the kit, as may the connection between the balloon syringe and the catheter lumen leading to the balloon and the connection between the oxygenator fluid output and the catheter lumen for feeding the oxygenated fluid.
- Nozzle 70 which extends from container 50 may be a stan ⁇ dard connector for connection to a source of pressurized oxygen such as a standard oxygen tank or other emergency room oxygen supply.
- the nozzle 70 is connected within the container 50, by means of tube 71, to a Y-junction 80 which divides the oxygen input into line 82, which leads to the oxygen in-port 46 of the oxygenator, and line 84, which leads to the pressurizable container 30.
- the oxygen out-port 48 of the oxygenator may be vented to the atmo ⁇ sphere. All of these lines may be sealed within the container 50.
- the regulator valve 34 is also present within the container 50 so as to regulate the maximum pressure of fluid entering the container 30 for pressur ⁇ izing the sack of oxygenating fluid 32.
- a rubber or plastic pressure bladder may be placed between the sack 32 and the pressure chamber 30 to diminish risk of damage to sack 32.
- a second regulator valve 86 may also be built-in at the oxygen in-port 46 of the oxygenator 40 in order to regulate the pressure of oxygen entering the oxygenator 40.
- the output port 37 from the sack 32 of oxygen ⁇ ating fluid may be directly connected to the oxygenating fluid inlet port 42 of the oxygenator 40 by means of a tube 74 sealed within the container 50.
- a valve 76 accessible from the outside of the container 50, may be used to open or close access of the oxygenating fluid from the sack 32 to the oxygenator input 42.
- the output from the oxygenator 40 through the out-port 44 may be directly connected to the fluid input cannula 18 of the catheter 12. Thus, no physical connections need be made by the emergency personnel except for attachment of an oxygen source to nozzle 70.
- the catheter 12 is removed from the compartment 52 of the kit.
- Lumen 18, which is much longer than is schematically shown in Fig. 4, is already con ⁇ nected to the output 44 of the oxygenator.
- Lumen 16 is also already connected to the syringe 60.
- Syringe 60 is preferably one which contains exactly the right amount of fluid to cause inflation of the balloon and is constructed so as to permit one-time use only. The use of such a pre ⁇ packaged syringe will eliminate the possibility of over- inflation and rupture of the balloon.
- a source of pres ⁇ surized oxygen is connected to the nozzle 70 of the con ⁇ tainer 50.
- the femoral artery 90 see Fig.
- the guide wire may be any standard flexible guide wire or it could be a specially designed guide wire of increased stiffness to facilitate placement directly up the aorta.
- An introducer sheath 64 is removed from the compartment 62 of the con ⁇ tainer 50 and then advanced over the wire into the femoral artery.
- the central trochar and the guide wire are re ⁇ moved from the introduced sheath and the distal end 20 of the catheter 12 is introduced through the sheath into the femoral artery and fed until the balloon reaches the appropriate position in the aorta as determined by the markings 22 and 24 on the catheter or by other known means.
- the guide wire can be left in place to facilitate placement of the catheter 12, the guide wire being removed after placement of the catheter 12.
- the balloon 14 is then inflated by means of the syringe 60 and the valve 76 is opened in order to permit the feeding of the oxygenating fluid through the oxygenator 40 and into the lumen 18 and opening 20 into the aorta at the prede ⁇ termined flow rate.
- oxygen will flow through the oxygenator, countercurrent to the flow of oxygenating fluid, and into the pressure chamber 30 to drive the flow of oxygenating fluid at the predetermined rate, determined by the regulator valve 34.
- the oxygen output from the oxygenator may include a bleed valve to ensure flow of oxygen through the oxygenator even when not necessary for pressurization of the chamber 30.
- This system will be efficacious in the treatment of cardiac arrest and its potential application is quite extensive. As stated previously, standard techniques for the treatment of cardiac arrest are useful only in the initial few minutes. It is believed that rapid applica ⁇ tion of the selective aortic perfusion system of the present invention will extend the period during which successful resuscitation could be obtained. The system should prove efficacious and it is believed that emergency departments and other critical care areas, and, potential ⁇ ly, life support ambulances, will be able to easily stock this particular piece of equipment and use the system of the present invention.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69229636T DE69229636D1 (en) | 1991-09-09 | 1992-09-09 | SELECTIVE AORTAPERFUSION SYSTEM |
JP50547493A JP2002514930A (en) | 1991-09-09 | 1992-09-09 | Selective aortic perfusion system |
EP92920154A EP0603308B1 (en) | 1991-09-09 | 1992-09-09 | Selective aortic perfusion system |
AU25952/92A AU671259B2 (en) | 1991-09-09 | 1992-09-09 | Selective aortic perfusion system |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/756,693 US5334142A (en) | 1991-09-09 | 1991-09-09 | Selective aortic perfusion system |
US756,693 | 1991-09-09 | ||
PCT/US1995/004531 WO1996032145A1 (en) | 1993-10-01 | 1995-04-11 | Selective aortic perfusion system |
CA002218092A CA2218092C (en) | 1991-09-09 | 1995-04-11 | Selective aortic perfusion system |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993004728A1 true WO1993004728A1 (en) | 1993-03-18 |
Family
ID=46202084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/007605 WO1993004728A1 (en) | 1991-09-09 | 1992-09-09 | Selective aortic perfusion system |
Country Status (5)
Country | Link |
---|---|
US (1) | US5334142A (en) |
EP (1) | EP0603308B1 (en) |
AU (1) | AU671259B2 (en) |
CA (2) | CA2118589A1 (en) |
WO (1) | WO1993004728A1 (en) |
Cited By (4)
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WO1996032145A1 (en) * | 1993-10-01 | 1996-10-17 | New York University | Selective aortic perfusion system |
AU696157B2 (en) * | 1995-04-11 | 1998-09-03 | New York University | Selective aortic perfusion system |
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EP3713502A4 (en) * | 2017-11-22 | 2021-07-07 | Front Line Medical Technologies Inc. | Devices and method for blood vessel occlusion |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996032145A1 (en) * | 1993-10-01 | 1996-10-17 | New York University | Selective aortic perfusion system |
AU696157B2 (en) * | 1995-04-11 | 1998-09-03 | New York University | Selective aortic perfusion system |
US8062259B2 (en) | 2006-07-06 | 2011-11-22 | Warsaw Orthopedic, Inc. | Cannulated sensing device |
EP3713502A4 (en) * | 2017-11-22 | 2021-07-07 | Front Line Medical Technologies Inc. | Devices and method for blood vessel occlusion |
Also Published As
Publication number | Publication date |
---|---|
CA2118589A1 (en) | 1993-03-18 |
AU671259B2 (en) | 1996-08-22 |
US5334142A (en) | 1994-08-02 |
EP0603308A1 (en) | 1994-06-29 |
CA2218092A1 (en) | 1996-10-17 |
CA2218092C (en) | 2005-01-04 |
EP0603308B1 (en) | 1999-07-21 |
EP0603308A4 (en) | 1995-06-28 |
AU2595292A (en) | 1993-04-05 |
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