WO1993005828A3 - Integrated centrifugal pump and membrane oxygenator - Google Patents

Integrated centrifugal pump and membrane oxygenator Download PDF

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Publication number
WO1993005828A3
WO1993005828A3 PCT/US1992/007928 US9207928W WO9305828A3 WO 1993005828 A3 WO1993005828 A3 WO 1993005828A3 US 9207928 W US9207928 W US 9207928W WO 9305828 A3 WO9305828 A3 WO 9305828A3
Authority
WO
WIPO (PCT)
Prior art keywords
fibers
centrifugal pump
membrane oxygenator
integrated centrifugal
layers
Prior art date
Application number
PCT/US1992/007928
Other languages
French (fr)
Other versions
WO1993005828A2 (en
Inventor
Wilfred F Mathewson
Original Assignee
Wilfred F Mathewson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilfred F Mathewson filed Critical Wilfred F Mathewson
Priority to EP92921081A priority Critical patent/EP0605621A1/en
Publication of WO1993005828A2 publication Critical patent/WO1993005828A2/en
Publication of WO1993005828A3 publication Critical patent/WO1993005828A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0231—Manufacturing thereof using supporting structures, e.g. filaments for weaving mats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A61M60/232—Centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/416—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted directly by the motor rotor drive shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/538—Regulation using real-time blood pump operational parameter data, e.g. motor current
    • A61M60/554—Regulation using real-time blood pump operational parameter data, e.g. motor current of blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/804—Impellers
    • A61M60/806—Vanes or blades
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/025—Bobbin units
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/02—Specific tightening or locking mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2066—Pulsated flow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/03—Heart-lung
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00—Gas and liquid contact apparatus
    • Y10S261/28—Blood oxygenators

Abstract

A low priming volume integrated centrifugal pump and membrane oxygenator comprising a housing (10) containing a mass transfer bed (40) comprising gas permeable hollow membrane fibers (38) placed circumferentially in a ring around an impeller (30). The mass transfer bed (40) is formed by a multiple wrap of a fiber ribbon (42) comprising at least two layers of fibers (38) bonded in precise orientation with fibers in alternate layers positioned in line with the opening between fibers in the layers above and below. Adhesion means ensure precise orientation of the fibers (38). Priming volume is further reduced by a small impeller flow channel volume.
PCT/US1992/007928 1991-09-25 1992-09-18 Integrated centrifugal pump and membrane oxygenator WO1993005828A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP92921081A EP0605621A1 (en) 1991-09-25 1992-09-18 Integrated centrifugal pump and membrane oxygenator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/765,307 US5263924A (en) 1991-09-25 1991-09-25 Integrated low priming volume centrifugal pump and membrane oxygenator
US765,307 1991-09-25

Publications (2)

Publication Number Publication Date
WO1993005828A2 WO1993005828A2 (en) 1993-04-01
WO1993005828A3 true WO1993005828A3 (en) 1993-04-29

Family

ID=25073197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/007928 WO1993005828A2 (en) 1991-09-25 1992-09-18 Integrated centrifugal pump and membrane oxygenator

Country Status (3)

Country Link
US (2) US5263924A (en)
EP (1) EP0605621A1 (en)
WO (1) WO1993005828A2 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05177117A (en) * 1991-10-23 1993-07-20 Hisateru Takano Substance exchange device
US5298016A (en) * 1992-03-02 1994-03-29 Advanced Haemotechnologies Apparatus for separating plasma and other wastes from blood
WO1994003266A1 (en) * 1992-08-03 1994-02-17 Maloney James V Jr Improved mass and thermal transfer means for use in heart lung machines, dialyzers, and other applications
IT1271104B (en) * 1994-11-25 1997-05-26 Dideco Spa BLOOD OXYGENATOR WITH A LAYER OF MICROPOROUS MEMBRANE CAPILLARIES.
WO1996016684A1 (en) * 1994-11-28 1996-06-06 Baxter International Inc. Integrated low priming volume centrifugal pump and membrane oxygenator
JP4031062B2 (en) * 1995-08-11 2008-01-09 株式会社荏原製作所 Plastic parts and manufacturing method thereof
US5749942A (en) * 1997-02-14 1998-05-12 Raychem Corporation Apparatus for extracting a gas from a liquid and delivering the gas to a collection station
US6106776A (en) * 1997-04-11 2000-08-22 University Of Pittsburgh Membrane apparatus with enhanced mass transfer via active mixing
US6723284B1 (en) * 1997-04-11 2004-04-20 University Of Pittsburgh Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
US6217826B1 (en) 1997-04-11 2001-04-17 University Of Pittsburgh Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
US6117390A (en) * 1998-03-27 2000-09-12 Medtronic, Inc. Compact blood oxygenator utilizing longitudinally interspersed transversely extending heat exchanger conduits and oxygenator fibers
US6454999B1 (en) 1998-12-30 2002-09-24 Cardiovention, Inc. Integrated blood pump and oxygenator system having extended blood flow path
US6224829B1 (en) 1998-12-30 2001-05-01 Cadiovention, Inc. Integrated blood oxygenator and pump system having means for reducing fiber breakage
US6368557B1 (en) 1998-12-30 2002-04-09 Cardiovention, Inc. Integrated blood oxygenator and pump system having means for reducing manifold flooding
US6428747B1 (en) 1998-12-30 2002-08-06 Cardiovention, Inc. Integrated extracorporeal blood oxygenator, pump and heat exchanger system
US6379618B1 (en) 1998-12-30 2002-04-30 Cardiovention, Inc. Integrated blood oxygenator and pump system having means for reducing microbubble generation
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6526357B1 (en) 1999-08-09 2003-02-25 Gambro, Inc. Associated parameter measuring and/or monitoring such as in the evaluation of pressure differences
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US7455657B2 (en) * 2001-06-19 2008-11-25 Boston Scientific Scimed, Inc Method and apparatus to modify a fluid using a selectively permeable membrane
US8147562B2 (en) * 2002-09-23 2012-04-03 The General Hospital Corporation Three dimensional construct for the design and fabrication of physiological fluidic networks
US7335301B2 (en) * 2002-11-22 2008-02-26 Koch Membrane Systems, Inc. Fold protection for spiral filtration modules utilizing UV cured adhesive and method of providing same
ATE439039T1 (en) * 2003-01-16 2009-08-15 Gen Hospital Corp USE OF THREE-DIMENSIONAL MICROMANUFACTURED TISSUE TECHNOLOGY SYSTEMS FOR PHARMACOLOGICAL APPLICATIONS
US20050085762A1 (en) * 2003-03-31 2005-04-21 Venkataramana Vijay Perfusion circuit for cardiopulmonary bypass with air removal system
US6852280B2 (en) 2003-03-31 2005-02-08 Venkataramana Vijay Condensed perfusion circuit for cardiopulmonary bypass and cardioplegia
US7960166B2 (en) * 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US8097456B2 (en) * 2003-08-18 2012-01-17 The Charles Stark Draper Laboratory Nanotopographic compositions and methods for cellular organization in tissue engineered structures
US20050040096A1 (en) * 2003-08-21 2005-02-24 Joseph Kuo Laminated modular water filter
JP2008517651A (en) * 2004-10-22 2008-05-29 コーブ・カーディオヴァスキュラー・インコーポレーテッド Convertible extracorporeal blood perfusion system
US7458952B2 (en) * 2004-11-18 2008-12-02 Venkataramana Vijay Integrated cardiopulmonary bypass system for open and closed bypass circuits
CN103381277B (en) 2005-04-21 2015-11-25 联邦高等教育系统匹兹堡大学 Paracorporeal respiratory assist lung
EP1971421B1 (en) * 2005-12-07 2011-07-06 Dow Global Technologies LLC Insertion-point seal for spiral wound module
AU2007207782B2 (en) * 2006-01-13 2012-09-27 Heartware, Inc. Rotary blood pump
US8585968B2 (en) * 2006-04-21 2013-11-19 Scott W. Morley Method and system for purging moisture from an oxygenator
JP4821466B2 (en) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 Droplet discharge head
EP1930034B1 (en) 2006-12-07 2012-11-14 Thoratec LLC An integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system
WO2008127732A2 (en) * 2007-04-12 2008-10-23 The General Hospital Corporation Biomimetic vascular network and devices using the same
WO2009039378A2 (en) * 2007-09-19 2009-03-26 The Charles Stark Draper Laboratory, Inc. Microfluidic structures for biomedical applications
WO2009096226A1 (en) * 2008-01-31 2009-08-06 National University Corporation Yokohama National University Fluid machine
US9595206B2 (en) 2008-02-11 2017-03-14 The General Hospital System and method for in vitro blood vessel modeling
US20100272604A1 (en) * 2009-04-23 2010-10-28 Medtronic, Inc. Radial Design Oxygenator with Heat Exchanger and Integrated Pump
US8545754B2 (en) 2009-04-23 2013-10-01 Medtronic, Inc. Radial design oxygenator with heat exchanger
DE202009016917U1 (en) 2009-12-04 2011-04-21 Ls Medcap Gmbh Gas exchange system
US20120157905A1 (en) * 2010-12-15 2012-06-21 Biovec Transfusion, Llc Methods for treating carbon monoxide poisoning by tangential flow filtration of blood
DE102011008329B4 (en) 2011-01-11 2012-09-27 Fresenius Medical Care Deutschland Gmbh Blood treatment unit for an extracorporeal blood treatment device
US9211369B2 (en) 2012-06-13 2015-12-15 Ension, Inc Compact integrated blood pump oxygenator or gas transfer device with hydrogel impeller packing material and rollover impeller outlet
EP2925382A4 (en) * 2012-11-28 2016-07-06 Univ Pittsburgh Extracorporeal ambulator assist lung
CN103551038B (en) * 2013-11-15 2015-03-11 周小山 Membrane separation device
US10188780B2 (en) 2013-12-23 2019-01-29 University Of Maryland, Baltimore Blood oxygenator
US10322222B2 (en) 2015-07-10 2019-06-18 Terumo Cardiovascular Systems Corporation Integrated medical pump and oxygenator
WO2017218987A1 (en) 2016-06-16 2017-12-21 Ension, Inc. Adult and pediatric extracorporeal life support system with heparin treated oxygenator surface and magnetic levitation motor
AU2018280236A1 (en) 2017-06-07 2020-01-16 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
JP7319266B2 (en) 2017-11-13 2023-08-01 シファメド・ホールディングス・エルエルシー Intravascular fluid transfer devices, systems and methods of use
US10833570B2 (en) 2017-12-22 2020-11-10 Massachusetts Institute Of Technology Homopolar bearingless slice motors
CN112004563A (en) 2018-02-01 2020-11-27 施菲姆德控股有限责任公司 Intravascular blood pump and methods of use and manufacture
CN109224165A (en) * 2018-11-27 2019-01-18 江苏美思康医疗科技有限公司 A kind of membrane oxygenator of the integrated centrifugal pump with alternating temperature
EP3996797A4 (en) 2019-07-12 2023-08-02 Shifamed Holdings, LLC Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11013841B2 (en) * 2019-09-28 2021-05-25 Choon Kee Lee Centrifugal-dialysate-flow hemodializer
EP3821972A1 (en) * 2019-11-12 2021-05-19 Fresenius Medical Care Deutschland GmbH Filter module for filtering a biotechnological fluid and use of a filter module for filtering a biotechnological fluid
US11040128B1 (en) * 2020-01-25 2021-06-22 Choon Kee Lee Integrated motorized hemodialyzer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487784A (en) * 1967-10-26 1970-01-06 Edson Howard Rafferty Pumps capable of use as heart pumps
US3771899A (en) * 1971-12-13 1973-11-13 R Brumfield Pulsator pump and heat exchanger for blood
US3841837A (en) * 1972-10-05 1974-10-15 Tecna Corp Oxygenator
US3989626A (en) * 1973-05-29 1976-11-02 Bentley Laboratories, Inc. Membrane transfer process and apparatus
EP0089122A2 (en) * 1982-02-19 1983-09-21 CD Medical, Inc. Hollow fibre oxygenator, assembly containing same and method for making same
WO1990004419A1 (en) * 1988-10-20 1990-05-03 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28742A (en) * 1860-06-19 Machine foe
BE448094A (en) *
US312788A (en) * 1885-02-24 Centrifugal pump
US700224A (en) * 1901-03-12 1902-05-20 John D Mcrae Centrifugal pump.
US865900A (en) * 1905-04-19 1907-09-10 Archibald W Hunsaker Automatically-balanced vertical-shaft centrifugal pump.
US1022425A (en) * 1910-10-18 1912-04-09 Gusta C Kuechler Centrifugal pump.
US1372532A (en) * 1920-03-08 1921-03-22 Soren C Monberg Air compressor or pump
US1986836A (en) * 1933-01-09 1935-01-08 Fairbanks Morse & Co Method of making centrifugal pumps
US2636442A (en) * 1950-04-08 1953-04-28 Mechanisms Company Centrifugal pump
US2876769A (en) * 1955-10-11 1959-03-10 Cordova Jose Juan Apparatus for oxygenating, centrifuging and changing the temperature of blood
US3107625A (en) * 1961-09-01 1963-10-22 Walter E Amberg Centrifugal liquid pump
US3183908A (en) * 1961-09-18 1965-05-18 Samuel C Collins Pump oxygenator system
US3139832A (en) * 1963-07-24 1964-07-07 Alan P Saunders Centrifugal enclosed inert pump
GB1028452A (en) * 1964-03-09 1966-05-04 Pulsometer Pumps Ltd Rotors for pumps or turbines
FR1513356A (en) * 1966-11-16 1968-02-16 Comp Generale Electricite Submerged centrifugal pump
US3489340A (en) * 1968-04-16 1970-01-13 Garrett Corp Centrifugal compressor
US3674440A (en) * 1970-05-07 1972-07-04 Tecna Corp Oxygenator
US3771658A (en) * 1971-10-20 1973-11-13 R Brumfield Blood transport membrane pump
IT949641B (en) * 1972-01-13 1973-06-11 Filippo G De IMPROVEMENT IN DISK OXYGENATORS FOR ASSISTED EXTRA BODY CIRCULATION OF THE BLOOD OF PATIENTS AFFECTED BY HEART INSUFFICIEN ZA
US3893920A (en) * 1973-05-03 1975-07-08 Dorr Oliver Inc Membrane separation equipment
NL7310808A (en) * 1973-08-06 1975-02-10 Josef Augustinus Elizabeth Spa DEVICE FOR EXCHANGE OF SUBSTANCES BETWEEN TWO ON EACH SIDE OF A MEMBRANE
US3901623A (en) * 1974-02-08 1975-08-26 Chandler Evans Inc Pivotal vane centrifugal
US4253798A (en) * 1978-08-08 1981-03-03 Eiichi Sugiura Centrifugal pump
US4312757A (en) * 1979-04-09 1982-01-26 Brumfield Robert C Methods and means for circulating a dialysate
US4283284A (en) * 1979-07-18 1981-08-11 Baxter Travenol Laboratories, Inc. Hollow fiber dialyzer end seal system
AU538322B2 (en) * 1979-10-29 1984-08-09 Rockwell International Inc. Composite centrifugal impeller
US4346006A (en) * 1980-03-24 1982-08-24 Baxter Travenol Laboratories, Inc. Diffusion membrane units with adhered semipermeable capillaries
JPS5739854A (en) * 1980-08-25 1982-03-05 Terumo Corp Hollow fiber type artificial lung building in heat exchanger
EP0053881B1 (en) * 1980-12-08 1985-05-02 Imperial Chemical Industries Plc Mass transfer apparatus
US4826401A (en) * 1981-07-02 1989-05-02 Tmt Research Development Inc. Centrifugal pump
US4715953A (en) * 1983-04-01 1987-12-29 Baxter Travenol Laboratories, Inc. Hollow fiber separation device manifold
US4622206A (en) * 1983-11-21 1986-11-11 University Of Pittsburgh Membrane oxygenator and method and apparatus for making the same
US4876013A (en) * 1983-12-20 1989-10-24 Membrex Incorporated Small volume rotary filter
US4790942A (en) * 1983-12-20 1988-12-13 Membrex Incorporated Filtration method and apparatus
JPS60193469A (en) * 1984-03-14 1985-10-01 三菱レイヨン株式会社 Hollow yarn membrane type artificial lung
FI73501C (en) * 1984-06-06 1987-10-09 Sarlin Ab Oy E Impeller at a pump.
US4713176A (en) * 1985-04-12 1987-12-15 Hemascience Laboratories, Inc. Plasmapheresis system and method
NL8501514A (en) * 1985-05-28 1986-12-16 Dow Chemical Nederland TRANSMISSION PIPE HEAT EXCHANGER.
US4808378A (en) * 1985-11-11 1989-02-28 Senko Medical Instrument Mfg. Co., Ltd. Blood oxygenator
US4755300A (en) * 1985-12-23 1988-07-05 Haemonetics Corporation Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
US4808307A (en) * 1985-12-23 1989-02-28 Haemonetics Corporation Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
IT1187933B (en) * 1986-02-25 1987-12-23 Gilardini Spa ROTARY PUMP FOR LIQUIDS
DE3615686A1 (en) * 1986-05-09 1987-11-12 Klein Schanzlin & Becker Ag CHANNEL WHEEL FOR CENTRIFUGAL PUMPS
US4808328A (en) * 1987-05-08 1989-02-28 Joseph N. Cooper Iodine-based antiseptic cleanser composition
US5236665A (en) * 1988-10-20 1993-08-17 Baxter International Inc. Hollow fiber treatment apparatus and membrane oxygenator
US5139741A (en) * 1988-12-29 1992-08-18 Terumo Kabushiki Kaisha Blood processing apparatus of hollow fiber type
US5017103A (en) * 1989-03-06 1991-05-21 St. Jude Medical, Inc. Centrifugal blood pump and magnetic coupling
DE3923692A1 (en) * 1989-07-18 1991-01-24 Helmut Prof Dr Ing Reul Medical blood treatment apparatus - has pump and heat exchanger which are mounted one behind other in common housing
JPH03111697A (en) * 1989-09-22 1991-05-13 Jidosha Denki Kogyo Co Ltd Small centrifugal pump
DE3943428C1 (en) * 1989-12-30 1991-01-31 Walter Stoecklin Ag, Aesch, Ch Shelving system for mechanised warehouse - has truck stop mechanism with slidable stop member with impact damping spring
DE4015331A1 (en) * 1990-05-12 1991-11-14 Klein Schanzlin & Becker Ag PADDLE WHEEL FOR CENTRIFUGAL PUMPS
IT1243345B (en) * 1990-07-16 1994-06-10 Dideco Spa CENTRIFUGAL PUMP FOR LIQUID, IN PARTICULAR BLOOD IN EXTRA-BODY CIRCULATION
US5376334A (en) * 1993-05-19 1994-12-27 Avecor Cardiovascular Inc. Mass transfer device having a hollow fiber bundle

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487784A (en) * 1967-10-26 1970-01-06 Edson Howard Rafferty Pumps capable of use as heart pumps
US3771899A (en) * 1971-12-13 1973-11-13 R Brumfield Pulsator pump and heat exchanger for blood
US3841837A (en) * 1972-10-05 1974-10-15 Tecna Corp Oxygenator
US3989626A (en) * 1973-05-29 1976-11-02 Bentley Laboratories, Inc. Membrane transfer process and apparatus
EP0089122A2 (en) * 1982-02-19 1983-09-21 CD Medical, Inc. Hollow fibre oxygenator, assembly containing same and method for making same
WO1990004419A1 (en) * 1988-10-20 1990-05-03 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger

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US5263924A (en) 1993-11-23
US5591404A (en) 1997-01-07
WO1993005828A2 (en) 1993-04-01
EP0605621A1 (en) 1994-07-13

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