WO1993011221A1 - Vorrichtung und verfahren zur isolierung und reinigung von nukleinsäuren - Google Patents
Vorrichtung und verfahren zur isolierung und reinigung von nukleinsäuren Download PDFInfo
- Publication number
- WO1993011221A1 WO1993011221A1 PCT/EP1992/002775 EP9202775W WO9311221A1 WO 1993011221 A1 WO1993011221 A1 WO 1993011221A1 EP 9202775 W EP9202775 W EP 9202775W WO 9311221 A1 WO9311221 A1 WO 9311221A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acids
- ionic strength
- buffer
- nucleic acid
- layer
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE59209549T DE59209549D1 (de) | 1991-12-02 | 1992-12-01 | Vorrichtung und verfahren zur isolierung und reinigung von nukleinsäuren |
DK92924637T DK0616639T3 (da) | 1991-12-02 | 1992-12-01 | Indretning og fremgangsmåde til isolering og oprensning af nukleinsyrer |
EP92924637A EP0616639B1 (de) | 1991-12-02 | 1992-12-01 | Vorrichtung und verfahren zur isolierung und reinigung von nukleinsäuren |
JP05509824A JP3115324B2 (ja) | 1991-12-02 | 1992-12-01 | 核酸を単離する装置及び方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4139664A DE4139664A1 (de) | 1991-12-02 | 1991-12-02 | Vorrichtung und verfahren zur isolierung und reinigung von nukleinsaeuren |
DEP4139664.2 | 1991-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993011221A1 true WO1993011221A1 (de) | 1993-06-10 |
Family
ID=6446064
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1992/002774 WO1993011218A1 (de) | 1991-12-02 | 1992-12-01 | Verfahren und vorrichtung zur isolierung von zellinhaltsstoffen wie nukleinsäuren aus natürlichen quellen |
PCT/EP1992/002775 WO1993011221A1 (de) | 1991-12-02 | 1992-12-01 | Vorrichtung und verfahren zur isolierung und reinigung von nukleinsäuren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1992/002774 WO1993011218A1 (de) | 1991-12-02 | 1992-12-01 | Verfahren und vorrichtung zur isolierung von zellinhaltsstoffen wie nukleinsäuren aus natürlichen quellen |
Country Status (6)
Country | Link |
---|---|
US (3) | US6277648B1 (de) |
EP (3) | EP0875271B1 (de) |
JP (3) | JP3329813B2 (de) |
DE (5) | DE4139664A1 (de) |
DK (2) | DK0875271T3 (de) |
WO (2) | WO1993011218A1 (de) |
Cited By (33)
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WO1995001359A1 (de) * | 1993-07-01 | 1995-01-12 | Qiagen Gmbh | Verfahren zur chromatographischen reinigung und trennung von nucleinsäuregemischen |
WO1995021177A1 (de) * | 1994-02-07 | 1995-08-10 | Qiagen Gmbh | Verfahren zur herstellung endotoxinfreier oder an endotoxin abgereicherter nucleinsäuren und/oder oligonucleotide für die gentherapie |
WO1995021178A1 (de) * | 1994-02-07 | 1995-08-10 | Qiagen Gmbh | Steigerung der transfektionseffizienz von nucleinsäuren durch die verwendung von isopropanol in wässrigen lösungen |
WO1995021849A1 (de) * | 1994-02-11 | 1995-08-17 | Qiagen Gmbh | Verfahren zur trennung von doppelstrang/einzelstrangnukleinsäurestrukturen |
EP0687912A2 (de) | 1994-06-15 | 1995-12-20 | Roche Diagnostics GmbH | Verfahren zur mehrmaligen Entnahme von Flüssigkeiten, und analytische Bestimmung, die dieses Verfahren verwendet |
WO1995034569A1 (de) * | 1994-06-14 | 1995-12-21 | Invitek Gmbh | Universelles verfahren zur isolierung und reinigung von nukleinsäuren aus extrem geringen mengen sowie sehr stark verunreinigten unterschiedlichsten ausgangsmaterialien |
EP0723549A1 (de) * | 1993-08-30 | 1996-07-31 | Promega Corporation | Zusammensetzungen und verfahren zur reinigung von nukleinsäuren |
US5783686A (en) * | 1995-09-15 | 1998-07-21 | Beckman Instruments, Inc. | Method for purifying nucleic acids from heterogenous mixtures |
US5981736A (en) * | 1997-06-27 | 1999-11-09 | Life Technologies, Inc. | One step device and process for concentration and purification of biological molecules |
US5990301A (en) * | 1994-02-07 | 1999-11-23 | Qiagen Gmbh | Process for the separation and purification of nucleic acids from biological sources |
US6136555A (en) * | 1993-07-09 | 2000-10-24 | Cambridge Molecular Technologies Limited | Purification method and apparatus |
DE10238630A1 (de) * | 2002-08-19 | 2004-03-04 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Verfahren zur Isolierung biologischer Makromoleküle sowie Vorrichtung zur Durchführung dieses Verfahrens |
WO2005090567A1 (en) * | 2004-03-18 | 2005-09-29 | Roche Diagnostics Gmbh | Method and device for purifying nucleic acids |
US7229595B2 (en) | 2001-06-15 | 2007-06-12 | Molecular Devices Corporation | Filtration column devices and methods of filtering therewith |
WO2008045505A2 (en) | 2006-10-10 | 2008-04-17 | Xenomics, Inc. | Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media |
EP2055385A1 (de) | 2007-10-31 | 2009-05-06 | Roche Diagnostics GmbH | Verfahren und Vorrichtung zur Reinigung von Nukleinsäuren |
US7556733B2 (en) | 2001-06-15 | 2009-07-07 | Mds Analytical Technologies (Us) Inc. | Low volume filtration column devices and methods of filtering therewith |
EP2128169A1 (de) | 2008-05-30 | 2009-12-02 | Qiagen GmbH | Verfahren zur Isolierung von kurzkettigen Nukleinsäuren |
WO2010072822A2 (de) | 2008-12-23 | 2010-07-01 | Qiagen Gmbh | Präparation und amplifikation von nukleinsäuren mittels magnetischer partikel |
US7749388B2 (en) | 2001-06-15 | 2010-07-06 | Life Technologies Corporation | Low volume filtration column devices and methods of filtering therewith |
WO2010076013A1 (de) | 2008-12-30 | 2010-07-08 | Qiagen Gmbh | Verfahren zum nachweis methicillin-resistenter staphylococcus aureus (mrsa)-stämme |
US7776273B2 (en) | 2000-04-26 | 2010-08-17 | Life Technologies Corporation | Laser capture microdissection (LCM) extraction device and device carrier, and method for post-LCM fluid processing |
US7846333B2 (en) | 2003-11-24 | 2010-12-07 | Effendorf AG | Porous media |
US8247545B1 (en) | 1991-12-02 | 2012-08-21 | Qiagen Gmbh | Device and a process for the isolation of nucleic acids |
WO2012122088A1 (en) * | 2011-03-09 | 2012-09-13 | 3M Innovative Properties Company | Apparatus and method for processing a sample |
WO2013004710A2 (en) | 2011-07-04 | 2013-01-10 | Qiagen Gmbh | Reagent usable for the isolation and/or purification of nucleic acids |
DE102013205794A1 (de) * | 2012-04-06 | 2013-10-10 | Cells Scientific Corp. | Filtrationssystem für biologische Proben und Verfahren zur Filtration biologischer Proben |
US8685742B2 (en) | 2004-07-15 | 2014-04-01 | Qiagen Gmbh | Apparatus and method for the more efficient isolation of nucleic acids |
EP2872523A4 (de) * | 2011-12-30 | 2016-05-25 | Abbott Molecular Inc | Mikroorganismus-nucleinsäurereinigung von wirtsproben |
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DE4422044A1 (de) * | 1994-06-14 | 1995-12-21 | Invitek Gmbh | Verfahren zur Isolierung, Reinigung und ggf. Lagerung von Nukleinsäuren |
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US5834303A (en) * | 1994-11-04 | 1998-11-10 | Tomy Seiko Co., Ltd. | Method and device for extraction and purification of DNA |
US5660984A (en) * | 1994-12-09 | 1997-08-26 | Davis; Thomas E. | DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof |
US5472600A (en) * | 1995-02-01 | 1995-12-05 | Minnesota Mining And Manufacturing Company | Gradient density filter |
DE19512369A1 (de) * | 1995-04-01 | 1996-10-02 | Boehringer Mannheim Gmbh | Vorrichtung zur Isolierung von Nukleinsäuren |
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- 1992-12-01 DE DE59209997T patent/DE59209997D1/de not_active Expired - Lifetime
- 1992-12-01 EP EP98107576A patent/EP0875271B1/de not_active Revoked
- 1992-12-01 DE DE59205979T patent/DE59205979D1/de not_active Expired - Lifetime
- 1992-12-01 WO PCT/EP1992/002774 patent/WO1993011218A1/de active IP Right Grant
- 1992-12-01 EP EP92924637A patent/EP0616639B1/de not_active Expired - Lifetime
- 1992-12-01 JP JP50982393A patent/JP3329813B2/ja not_active Expired - Lifetime
- 1992-12-01 DK DK98107576T patent/DK0875271T3/da active
- 1992-12-01 EP EP92924636A patent/EP0616638B1/de not_active Expired - Lifetime
- 1992-12-01 DE DE59209549T patent/DE59209549D1/de not_active Expired - Lifetime
- 1992-12-01 WO PCT/EP1992/002775 patent/WO1993011221A1/de active IP Right Grant
- 1992-12-01 DK DK92924637T patent/DK0616639T3/da active
- 1992-12-01 JP JP05509824A patent/JP3115324B2/ja not_active Expired - Lifetime
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1994
- 1994-06-02 US US08/253,152 patent/US6277648B1/en not_active Expired - Lifetime
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1997
- 1997-02-05 US US08/796,040 patent/US8247545B1/en not_active Expired - Fee Related
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2000
- 2000-07-25 JP JP2000223370A patent/JP3527884B2/ja not_active Expired - Lifetime
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2001
- 2001-07-09 US US09/900,199 patent/US6609618B2/en not_active Expired - Fee Related
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EP0723549A1 (de) * | 1993-08-30 | 1996-07-31 | Promega Corporation | Zusammensetzungen und verfahren zur reinigung von nukleinsäuren |
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EP0687912A2 (de) | 1994-06-15 | 1995-12-20 | Roche Diagnostics GmbH | Verfahren zur mehrmaligen Entnahme von Flüssigkeiten, und analytische Bestimmung, die dieses Verfahren verwendet |
US5783686A (en) * | 1995-09-15 | 1998-07-21 | Beckman Instruments, Inc. | Method for purifying nucleic acids from heterogenous mixtures |
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Also Published As
Publication number | Publication date |
---|---|
JP3115324B2 (ja) | 2000-12-04 |
DE59209997D1 (de) | 2004-05-27 |
EP0875271A2 (de) | 1998-11-04 |
DK0875271T3 (da) | 2004-08-09 |
DE4139664A1 (de) | 1993-06-03 |
DK0616639T3 (da) | 1999-07-19 |
US8247545B1 (en) | 2012-08-21 |
JPH07501223A (ja) | 1995-02-09 |
DE4143639C2 (de) | 2002-10-24 |
EP0616639B1 (de) | 1998-11-04 |
JPH07501222A (ja) | 1995-02-09 |
US6609618B2 (en) | 2003-08-26 |
EP0616638B1 (de) | 1996-04-10 |
US20010047966A1 (en) | 2001-12-06 |
EP0616638A1 (de) | 1994-09-28 |
DE59209549D1 (de) | 1998-12-10 |
DE59205979D1 (de) | 1996-05-15 |
JP3527884B2 (ja) | 2004-05-17 |
EP0616639A1 (de) | 1994-09-28 |
WO1993011218A1 (de) | 1993-06-10 |
EP0875271A3 (de) | 2001-04-25 |
JP3329813B2 (ja) | 2002-09-30 |
JP2001095572A (ja) | 2001-04-10 |
US6277648B1 (en) | 2001-08-21 |
EP0875271B1 (de) | 2004-04-21 |
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