WO1993022678A3 - Optical and electrical methods and apparatus for molecule detection - Google Patents

Optical and electrical methods and apparatus for molecule detection Download PDF

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Publication number
WO1993022678A3
WO1993022678A3 PCT/US1993/003829 US9303829W WO9322678A3 WO 1993022678 A3 WO1993022678 A3 WO 1993022678A3 US 9303829 W US9303829 W US 9303829W WO 9322678 A3 WO9322678 A3 WO 9322678A3
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WIPO (PCT)
Prior art keywords
optical
molecule detection
test sites
electrical methods
structures
Prior art date
Application number
PCT/US1993/003829
Other languages
French (fr)
Other versions
WO1993022678A2 (en
Inventor
Mark A Hollis
Daniel J Ehrlich
Allen R Murphy
Bernard B Kosicki
Dennis D Rathman
Chang-Lee Chen
Richard H Mathews
Barry E Burke
Mitch D Eggers
Michael E Hogan
Rajender Singh Varma
Original Assignee
Massachusetts Inst Technology
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25359894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1993022678(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority to DE69333687T priority Critical patent/DE69333687T2/en
Priority to JP51939693A priority patent/JP3447055B2/en
Priority to EP93910751A priority patent/EP0638173B1/en
Publication of WO1993022678A2 publication Critical patent/WO1993022678A2/en
Publication of WO1993022678A3 publication Critical patent/WO1993022678A3/en

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Abstract

A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
PCT/US1993/003829 1992-04-23 1993-04-23 Optical and electrical methods and apparatus for molecule detection WO1993022678A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69333687T DE69333687T2 (en) 1992-04-23 1993-04-23 OPTICAL AND ELECTRICAL METHODS FOR DETERMINING MOLECULES
JP51939693A JP3447055B2 (en) 1992-04-23 1993-04-23 Electrical method and apparatus for molecule detection
EP93910751A EP0638173B1 (en) 1992-04-23 1993-04-23 Optical and electrical methods for molecule detection

Applications Claiming Priority (2)

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US07/872,582 1992-04-23
US07/872,582 US5846708A (en) 1991-11-19 1992-04-23 Optical and electrical methods and apparatus for molecule detection

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WO1993022678A2 WO1993022678A2 (en) 1993-11-11
WO1993022678A3 true WO1993022678A3 (en) 1994-02-03

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EP (4) EP1143015A3 (en)
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