WO1994028908A2 - (phospho)lipids for combatting hepatitis b virus infection - Google Patents
(phospho)lipids for combatting hepatitis b virus infection Download PDFInfo
- Publication number
- WO1994028908A2 WO1994028908A2 PCT/US1994/005855 US9405855W WO9428908A2 WO 1994028908 A2 WO1994028908 A2 WO 1994028908A2 US 9405855 W US9405855 W US 9405855W WO 9428908 A2 WO9428908 A2 WO 9428908A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- hydroxyl
- alkoxy
- group
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002164717A CA2164717C (en) | 1993-06-10 | 1994-05-25 | Method of combatting hepatitis b virus infection |
DE69431596T DE69431596T4 (en) | 1993-06-10 | 1994-05-25 | (PHOSPHO) LIPIDS TO COMBAT HEPATITIS B INFECTION |
DE69431596A DE69431596D1 (en) | 1993-06-10 | 1994-05-25 | (PHOSPHO) LIPIDS TO COMBAT HEPATITIS B INFECTION |
EP94919231A EP0702556B1 (en) | 1993-06-10 | 1994-05-25 | (phospho)lipids for combatting hepatitis b virus infection |
AT94919231T ATE226437T1 (en) | 1993-06-10 | 1994-05-25 | (PHOSPHO)LIPIDS TO FIGHT HEPATITIS B INFECTION |
AU70448/94A AU7044894A (en) | 1993-06-10 | 1994-05-25 | (phospho)lipids for combatting hepatitis b virus infection |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7494393A | 1993-06-10 | 1993-06-10 | |
US074,943 | 1993-06-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994028908A2 true WO1994028908A2 (en) | 1994-12-22 |
WO1994028908A3 WO1994028908A3 (en) | 1995-03-23 |
Family
ID=22122581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/005855 WO1994028908A2 (en) | 1993-06-10 | 1994-05-25 | (phospho)lipids for combatting hepatitis b virus infection |
Country Status (7)
Country | Link |
---|---|
US (2) | US5770584A (en) |
EP (1) | EP0702556B1 (en) |
AT (1) | ATE226437T1 (en) |
AU (1) | AU7044894A (en) |
CA (1) | CA2164717C (en) |
DE (2) | DE69431596D1 (en) |
WO (1) | WO1994028908A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
US7749983B2 (en) | 2006-05-03 | 2010-07-06 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448392B1 (en) | 1985-03-06 | 2002-09-10 | Chimerix, Inc. | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use |
US6599887B2 (en) | 1988-07-07 | 2003-07-29 | Chimerix, Inc. | Methods of treating viral infections using antiviral liponucleotides |
ATE395922T1 (en) * | 1994-08-29 | 2008-06-15 | Univ Wake Forest | LIPID ANALOGUES FOR THE TREATMENT OF VIRAL INFECTIONS |
US7135584B2 (en) * | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
US6995299B2 (en) * | 1999-11-02 | 2006-02-07 | University Of Connecticut | Propagation of human hepatocytes in non-human animals |
US6670342B2 (en) | 2000-03-29 | 2003-12-30 | Georgetown University | Method of treating hepatitis delta virus infection |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
AU2002227252A1 (en) * | 2000-12-01 | 2002-06-11 | Cornell Research Foundation | Animal model for flaviviridae infection |
KR20030041130A (en) * | 2001-05-29 | 2003-05-23 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | Metal-ceramic bond |
CN100469131C (en) * | 2001-08-31 | 2009-03-11 | 汤姆森许可公司 | Sequence counter for an audio visual stream |
EP1435974A4 (en) * | 2001-09-28 | 2006-09-06 | Idenix Cayman Ltd | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
JP2006507235A (en) * | 2002-08-01 | 2006-03-02 | フアーマセツト・インコーポレイテツド | Compounds having bicyclo [4.2.1] nonane system for the treatment of Flaviviridae virus infection |
US20050187191A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Louis S. | Methods and compositions for the treatment of respiratory syncytial virus |
US20050187192A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Pharmaceutical Company | Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses |
WO2005094322A2 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
EP1789043A2 (en) * | 2004-08-13 | 2007-05-30 | Migenix Inc. | Compositions and methods for treating or preventing hepadnaviridae infection |
EP2842559A3 (en) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
EP1868628B1 (en) * | 2005-04-08 | 2014-06-11 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
WO2008118879A2 (en) * | 2007-03-23 | 2008-10-02 | Ardea Biosciences, Inc. | Antiviral compositions comprising 2 compounds |
US8671658B2 (en) | 2007-10-23 | 2014-03-18 | Ener-Core Power, Inc. | Oxidizing fuel |
US8393160B2 (en) | 2007-10-23 | 2013-03-12 | Flex Power Generation, Inc. | Managing leaks in a gas turbine system |
US8741966B2 (en) * | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
WO2009094190A2 (en) * | 2008-01-25 | 2009-07-30 | Chimerix, Inc. | Methods of treating viral infections |
EP2147910A1 (en) * | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
US8701413B2 (en) | 2008-12-08 | 2014-04-22 | Ener-Core Power, Inc. | Oxidizing fuel in multiple operating modes |
US8621869B2 (en) | 2009-05-01 | 2014-01-07 | Ener-Core Power, Inc. | Heating a reaction chamber |
JP5843755B2 (en) | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS | Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas |
US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
EP3216789A1 (en) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Methods of treating viral infection |
US8893468B2 (en) | 2010-03-15 | 2014-11-25 | Ener-Core Power, Inc. | Processing fuel and water |
AU2011248620B2 (en) | 2010-04-26 | 2015-11-26 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
SG190114A1 (en) | 2010-11-05 | 2013-07-31 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
US9057028B2 (en) | 2011-05-25 | 2015-06-16 | Ener-Core Power, Inc. | Gasifier power plant and management of wastes |
US9279364B2 (en) | 2011-11-04 | 2016-03-08 | Ener-Core Power, Inc. | Multi-combustor turbine |
US9273606B2 (en) | 2011-11-04 | 2016-03-01 | Ener-Core Power, Inc. | Controls for multi-combustor turbine |
US8809354B2 (en) | 2011-12-31 | 2014-08-19 | Sheikh Riazuddin | 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections |
US9359948B2 (en) | 2012-03-09 | 2016-06-07 | Ener-Core Power, Inc. | Gradual oxidation with heat control |
US9273608B2 (en) | 2012-03-09 | 2016-03-01 | Ener-Core Power, Inc. | Gradual oxidation and autoignition temperature controls |
US9381484B2 (en) | 2012-03-09 | 2016-07-05 | Ener-Core Power, Inc. | Gradual oxidation with adiabatic temperature above flameout temperature |
US9328660B2 (en) | 2012-03-09 | 2016-05-03 | Ener-Core Power, Inc. | Gradual oxidation and multiple flow paths |
US8980193B2 (en) | 2012-03-09 | 2015-03-17 | Ener-Core Power, Inc. | Gradual oxidation and multiple flow paths |
US9534780B2 (en) | 2012-03-09 | 2017-01-03 | Ener-Core Power, Inc. | Hybrid gradual oxidation |
US8844473B2 (en) | 2012-03-09 | 2014-09-30 | Ener-Core Power, Inc. | Gradual oxidation with reciprocating engine |
US9726374B2 (en) | 2012-03-09 | 2017-08-08 | Ener-Core Power, Inc. | Gradual oxidation with flue gas |
US9567903B2 (en) | 2012-03-09 | 2017-02-14 | Ener-Core Power, Inc. | Gradual oxidation with heat transfer |
US9206980B2 (en) | 2012-03-09 | 2015-12-08 | Ener-Core Power, Inc. | Gradual oxidation and autoignition temperature controls |
US9353946B2 (en) | 2012-03-09 | 2016-05-31 | Ener-Core Power, Inc. | Gradual oxidation with heat transfer |
US9234660B2 (en) | 2012-03-09 | 2016-01-12 | Ener-Core Power, Inc. | Gradual oxidation with heat transfer |
US9328916B2 (en) | 2012-03-09 | 2016-05-03 | Ener-Core Power, Inc. | Gradual oxidation with heat control |
US8807989B2 (en) | 2012-03-09 | 2014-08-19 | Ener-Core Power, Inc. | Staged gradual oxidation |
US9347664B2 (en) | 2012-03-09 | 2016-05-24 | Ener-Core Power, Inc. | Gradual oxidation with heat control |
US8980192B2 (en) | 2012-03-09 | 2015-03-17 | Ener-Core Power, Inc. | Gradual oxidation below flameout temperature |
US9371993B2 (en) | 2012-03-09 | 2016-06-21 | Ener-Core Power, Inc. | Gradual oxidation below flameout temperature |
US8671917B2 (en) | 2012-03-09 | 2014-03-18 | Ener-Core Power, Inc. | Gradual oxidation with reciprocating engine |
US8926917B2 (en) | 2012-03-09 | 2015-01-06 | Ener-Core Power, Inc. | Gradual oxidation with adiabatic temperature above flameout temperature |
US9359947B2 (en) | 2012-03-09 | 2016-06-07 | Ener-Core Power, Inc. | Gradual oxidation with heat control |
US9267432B2 (en) | 2012-03-09 | 2016-02-23 | Ener-Core Power, Inc. | Staged gradual oxidation |
US9017618B2 (en) | 2012-03-09 | 2015-04-28 | Ener-Core Power, Inc. | Gradual oxidation with heat exchange media |
MX2015011074A (en) | 2013-02-28 | 2016-03-09 | Pronova Biopharma Norge As | A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same. |
JP6784696B2 (en) | 2015-04-28 | 2020-11-11 | プロノヴァ バイオファーマ ノルゲ エーエス | Use of structurally fortified fatty acids containing sulfur for the prevention and / or treatment of non-alcoholic steatohepatitis |
KR20200096791A (en) | 2017-12-06 | 2020-08-13 | 바스프 에이에스 | Fatty acid derivatives for the treatment of non-alcoholic steatohepatitis |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235877A (en) * | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
EP0252310A2 (en) * | 1986-06-12 | 1988-01-13 | Merz & Co. GmbH & Co. | Antimicrobial agents |
US4797479A (en) * | 1985-04-15 | 1989-01-10 | Toyo Jozo Kabushiki Kaisha | Nucleoside-phospholipid conjugate |
JPS6429319A (en) * | 1987-07-23 | 1989-01-31 | Toyama Chemical Co Ltd | Antiviral agent containing lysolecithin and phospholipid |
WO1990015601A1 (en) * | 1989-06-12 | 1990-12-27 | Research Foundation For Mental Hygiene, Inc. | Reducing the spread of infection by blood handling equipment |
EP0416401A2 (en) * | 1989-09-02 | 1991-03-13 | Roche Diagnostics GmbH | Use of derivatives of phospholipides as antiviral pharmaceuticals and phospholipides |
EP0434450A2 (en) * | 1989-12-22 | 1991-06-26 | The Wellcome Foundation Limited | Therapeutic nucleosides |
WO1991009602A2 (en) * | 1989-12-23 | 1991-07-11 | Boehringer Mannheim Gmbh | Use of alkyl phospholipids as antiviral drugs, as well as new compounds |
US5034394A (en) * | 1988-06-27 | 1991-07-23 | Burroughs Wellcome Co. | Therapeutic nucleosides |
WO1991018914A1 (en) * | 1990-05-29 | 1991-12-12 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
WO1992003462A1 (en) * | 1990-08-20 | 1992-03-05 | Boehringer Mannheim Gmbh | New phospholipid derivatives of nucleosides, their preparation and their use as antiviral drugs |
WO1993008807A1 (en) * | 1991-10-28 | 1993-05-13 | Fost Dennis L | Phospholipid antimicrobial compositions |
WO1993016091A1 (en) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | New liponucleotides, their preparation and their use as antiviral medicaments |
WO1993016092A1 (en) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | New lipophosphonic acid-nucleoside conjugates and their use as antiviral medicaments |
EP0632048A1 (en) * | 1993-06-29 | 1995-01-04 | Mitsubishi Chemical Corporation | Phosphonate-nucleotide ester derivatives |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2108765A (en) * | 1938-02-15 | Preserving and disinfecting media | ||
US2086585A (en) * | 1933-04-13 | 1937-07-13 | Alba Pharmaceutical Company In | Quaternary ammonium compounds |
US2087132A (en) * | 1933-04-13 | 1937-07-13 | Alba Pharmaceutical Company In | Quaternary ammonium compounds |
US2209383A (en) * | 1938-03-05 | 1940-07-30 | Rohm & Haas | Process of waterproofing fabrics |
US2445393A (en) * | 1944-03-08 | 1948-07-20 | Rhone Poulenc Sa | New amino-derivatives of dioxa-cyclopentane |
US2439969A (en) * | 1944-04-17 | 1948-04-20 | Rhone Poulenc Sa | Amino-dioxacyclopentanes |
US2513747A (en) * | 1945-10-04 | 1950-07-04 | Ciba Ltd | Cyclic amino-acetals |
US2606909A (en) * | 1947-08-01 | 1952-08-12 | Univ Michigan | Basic dioxolanes |
US2689790A (en) * | 1951-09-26 | 1954-09-21 | Monsanto Chemicals | Nitrogenous compound herbicides |
DE1050298B (en) * | 1953-07-29 | 1959-02-12 | Böhme Fettchemie G.m.b.H., Düsseldorf | Multi-liquor washing process |
US3054678A (en) * | 1958-04-16 | 1962-09-18 | Michener Harold David | Preservation process with quaternary ammonium compounds |
DE1619043B2 (en) * | 1967-04-07 | 1977-11-03 | Hoechst Ag, 6000 Frankfurt | AGENT FOR SOFTENING TEXTILES AND AT THE SAME TIME PROVIDING GOOD ABSORPTION |
US4119714A (en) * | 1970-02-27 | 1978-10-10 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. | Glycerin-alkylether-(1)-phosphoric acid-(3)-monocholine esters as enhancers of the natural resistance of the mammalian organism against non-carcinogenic pathogens |
DE2033359C3 (en) * | 1970-07-06 | 1980-02-14 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Acylpropanediol- (1,3) -phosphoric acid monocholine ester and process for their preparation |
JPS49100224A (en) * | 1973-01-29 | 1974-09-21 | ||
US4093714A (en) * | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
US4159988A (en) * | 1974-08-06 | 1979-07-03 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Synthetic phospholipids, a process for their manufacture and their use |
FR2356425A1 (en) * | 1976-07-01 | 1978-01-27 | Roussel Uclaf | APPLICATION AS MEDICINAL PRODUCTS FROM ORGANIC DERIVATIVES OF MONTMORILLONITE |
US4329302A (en) * | 1980-06-27 | 1982-05-11 | Board Of Regents, The University Of Texas System | Synthetic phosphoglycerides possessing platelet activating properties |
DE3164332D1 (en) * | 1980-10-21 | 1984-07-26 | Boehringer Mannheim Gmbh | Phospholipids that contain sulphur, process for their preparation and medicines containing these compounds |
JPS5772914A (en) * | 1980-10-22 | 1982-05-07 | Takeda Chem Ind Ltd | Antitumor agent |
US4471113A (en) * | 1982-02-03 | 1984-09-11 | The United States Of America As Represented By The Department Of Energy | Prodrugs based on phospholipid-nucleoside conjugates |
EP0094586A3 (en) * | 1982-05-13 | 1984-06-06 | Ono Pharmaceutical Co., Ltd. | Glycerol derivatives, process for preparing same and pharmaceutical composition containing same |
US4661509A (en) * | 1982-09-28 | 1987-04-28 | Gordon Arnold Z | Methods for treating leukopenia |
JPS5988447A (en) * | 1982-11-11 | 1984-05-22 | Ono Pharmaceut Co Ltd | Glycerol derivative, its production and agent containing said derivative |
FR2540122B1 (en) * | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | NOVEL COMPOUNDS COMPRISING A SEQUENCE OF OLIGONUCLEOTIDE LINKED TO AN INTERCALATION AGENT, THEIR SYNTHESIS PROCESS AND THEIR APPLICATION |
JPS60100544A (en) * | 1983-11-08 | 1985-06-04 | Ono Pharmaceut Co Ltd | Novel glycerin derivative, its preparation and drug containing it |
JPS60104066A (en) * | 1983-11-10 | 1985-06-08 | Ono Pharmaceut Co Ltd | Glycerin derivative, its preparation, and drug containing it |
JPS60105650A (en) * | 1983-11-14 | 1985-06-11 | Ono Pharmaceut Co Ltd | Glycerol derivative, production thereof and pharmaceutical containing said derivative |
US4540521A (en) * | 1984-01-16 | 1985-09-10 | National Distillers And Chemical Corporation | Liquid quaternary ammonium antistatic compositions |
US4826823A (en) * | 1985-02-05 | 1989-05-02 | Warner-Lambert Company | Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts |
US4619917A (en) * | 1985-07-18 | 1986-10-28 | Sandoz Pharm. Corp. | Substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts |
CA1280369C (en) * | 1985-12-04 | 1991-02-19 | Hansjorg Eibl | Pharmaceutical with anti-tumor effect |
US4841039A (en) * | 1986-05-01 | 1989-06-20 | Emory University | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
US4880782A (en) * | 1986-11-21 | 1989-11-14 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. | Method of treating viral infections in humans and compositions therefor |
DE3726945A1 (en) * | 1987-08-13 | 1989-02-23 | Dietl Hans | L-Carnitine derivatives of valproic acid and pharmaceuticals containing these |
US4894389A (en) * | 1987-10-02 | 1990-01-16 | Merrell Dow Pharmaceuticals Inc. | Novel aminoalkyl-substituted heterocyclic sulfur compounds |
EP0335396A1 (en) * | 1988-04-01 | 1989-10-04 | MAGIS FARMACEUTICI S.p.A. | Glycero-phosphoric and -diphosphoric acids derivatives of L-carnitine or L-carnitine esters |
EP0348859A1 (en) * | 1988-07-01 | 1990-01-03 | MAGIS FARMACEUTICI S.p.A. | 1,2-di-O-acyl glycero(DI)phosphate of L-carnitine and its derivatives, a process for their preparation and pharmaceutical formulations which contain them |
GB8827337D0 (en) * | 1988-11-23 | 1988-12-29 | Medical Res Council | Nucleoside analogues |
DE3934820A1 (en) * | 1989-10-19 | 1991-04-25 | Boehringer Mannheim Gmbh | USE OF LECITHIN ANALOGA AS AN ANTIVIRAL MEDICINAL PRODUCT AND NEW DERIVATIVES |
BR9007769A (en) * | 1989-10-20 | 1992-08-11 | Lynxvale Ltd | PREPARATION FOR THE TREATMENT OF OTHERS TISSUE, PROCESS FOR THE PREPARATION OF EX-VIVO OTHERS TISSUE BEFORE TRANSPLANTATION OR THEIR USE AS A CURING MATERIAL, PROCESS FOR THE TREATMENT OF A PATIENT, AND, PROCESS FOR PERFORMING ALLOGENIC OR XENOGENIC ORGAN ORGAN TRANSPLANTS A HUMAN PATIENT, OR TO PROVIDE ALLOGENIC OR XENOGENIC DRESSING TO THIS PATIENT |
US5138045A (en) * | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
GB9204015D0 (en) * | 1992-02-25 | 1992-04-08 | Wellcome Found | Therapeutic nucleosides |
-
1994
- 1994-05-25 DE DE69431596A patent/DE69431596D1/en not_active Expired - Lifetime
- 1994-05-25 WO PCT/US1994/005855 patent/WO1994028908A2/en active IP Right Grant
- 1994-05-25 CA CA002164717A patent/CA2164717C/en not_active Expired - Fee Related
- 1994-05-25 DE DE69431596T patent/DE69431596T4/en not_active Expired - Lifetime
- 1994-05-25 EP EP94919231A patent/EP0702556B1/en not_active Expired - Lifetime
- 1994-05-25 AU AU70448/94A patent/AU7044894A/en not_active Abandoned
- 1994-05-25 AT AT94919231T patent/ATE226437T1/en not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/465,947 patent/US5770584A/en not_active Expired - Lifetime
-
1998
- 1998-06-22 US US09/102,308 patent/US6030960A/en not_active Expired - Fee Related
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235877A (en) * | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US4797479A (en) * | 1985-04-15 | 1989-01-10 | Toyo Jozo Kabushiki Kaisha | Nucleoside-phospholipid conjugate |
EP0252310A2 (en) * | 1986-06-12 | 1988-01-13 | Merz & Co. GmbH & Co. | Antimicrobial agents |
JPS6429319A (en) * | 1987-07-23 | 1989-01-31 | Toyama Chemical Co Ltd | Antiviral agent containing lysolecithin and phospholipid |
US5034394A (en) * | 1988-06-27 | 1991-07-23 | Burroughs Wellcome Co. | Therapeutic nucleosides |
WO1990015601A1 (en) * | 1989-06-12 | 1990-12-27 | Research Foundation For Mental Hygiene, Inc. | Reducing the spread of infection by blood handling equipment |
EP0416401A2 (en) * | 1989-09-02 | 1991-03-13 | Roche Diagnostics GmbH | Use of derivatives of phospholipides as antiviral pharmaceuticals and phospholipides |
EP0434450A2 (en) * | 1989-12-22 | 1991-06-26 | The Wellcome Foundation Limited | Therapeutic nucleosides |
WO1991009602A2 (en) * | 1989-12-23 | 1991-07-11 | Boehringer Mannheim Gmbh | Use of alkyl phospholipids as antiviral drugs, as well as new compounds |
WO1991018914A1 (en) * | 1990-05-29 | 1991-12-12 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
WO1992003462A1 (en) * | 1990-08-20 | 1992-03-05 | Boehringer Mannheim Gmbh | New phospholipid derivatives of nucleosides, their preparation and their use as antiviral drugs |
WO1993008807A1 (en) * | 1991-10-28 | 1993-05-13 | Fost Dennis L | Phospholipid antimicrobial compositions |
WO1993016091A1 (en) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | New liponucleotides, their preparation and their use as antiviral medicaments |
WO1993016092A1 (en) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | New lipophosphonic acid-nucleoside conjugates and their use as antiviral medicaments |
EP0632048A1 (en) * | 1993-06-29 | 1995-01-04 | Mitsubishi Chemical Corporation | Phosphonate-nucleotide ester derivatives |
Non-Patent Citations (2)
Title |
---|
CHEMICAL ABSTRACTS, vol. 105, no. 5, 4 August 1986, Columbus, Ohio, US; abstract no. 35587k, N.B. BOLDANOVA ET AL. 'Protective effect of phosphatidylcholine-containing liposomes in experimental toxic hepatitis' page 67 ; & VOPR. MED. KHIM., vol.32, no.3, 1986 * |
DATABASE WPI Week 8910, Derwent Publications Ltd., London, GB; AN 89-074674 & JP,A,1 029 319 (TOYAMA CHEM. K.K.) 31 January 1989 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
US7749983B2 (en) | 2006-05-03 | 2010-07-06 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
US7994143B2 (en) | 2006-05-03 | 2011-08-09 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
Also Published As
Publication number | Publication date |
---|---|
DE69431596T2 (en) | 2003-06-26 |
DE69431596D1 (en) | 2002-11-28 |
EP0702556B1 (en) | 2002-10-23 |
CA2164717A1 (en) | 1994-12-22 |
ATE226437T1 (en) | 2002-11-15 |
DE69431596T4 (en) | 2003-10-30 |
CA2164717C (en) | 2009-10-20 |
US5770584A (en) | 1998-06-23 |
US6030960A (en) | 2000-02-29 |
AU7044894A (en) | 1995-01-03 |
WO1994028908A3 (en) | 1995-03-23 |
EP0702556A1 (en) | 1996-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0702556B1 (en) | (phospho)lipids for combatting hepatitis b virus infection | |
US7294621B2 (en) | Lipid analogs for combating tumors | |
EP0792275B1 (en) | Improved antiviral prodrugs | |
RU2157215C2 (en) | Method of treatment of patients with infections induced by hepatitis b virus | |
JP4782365B2 (en) | Compositions and methods for dual targeting of viral infections and cancer cells | |
AU711774B2 (en) | Prodrugs of pharmaceuticals with improved bioavailability | |
US7294619B2 (en) | Lipid analogs for inhibiting the activity of hepatitis B antigen | |
JP5031162B2 (en) | Compositions and methods for dual targeting viral infection and targeting cancer cells | |
AU3043300A (en) | Use of bisphosphonates for the prevention and treatment of infectious processes | |
JPH0755906B2 (en) | Analgesic containing disaturated derivative | |
EP0080305A1 (en) | Antiviral 2'-deoxyuridines, their preparation and use | |
CS245797B2 (en) | Production method of muramylpeptides | |
JPS5984896A (en) | Phosphoric acid ester derivative of guanine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB GE HU JP KG KP KR KZ LK LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB GE HU JP KG KP KR KZ LK LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2164717 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1994919231 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1994919231 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 1994919231 Country of ref document: EP |