WO1995002987A3 - Examination of breast tissue using time-resolved spectroscopy - Google Patents

Examination of breast tissue using time-resolved spectroscopy Download PDF

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Publication number
WO1995002987A3
WO1995002987A3 PCT/US1994/007984 US9407984W WO9502987A3 WO 1995002987 A3 WO1995002987 A3 WO 1995002987A3 US 9407984 W US9407984 W US 9407984W WO 9502987 A3 WO9502987 A3 WO 9502987A3
Authority
WO
WIPO (PCT)
Prior art keywords
breast tissue
examined
tissue
breast
pulses
Prior art date
Application number
PCT/US1994/007984
Other languages
French (fr)
Other versions
WO1995002987A2 (en
Inventor
Britton Chance
Original Assignee
Non Invasive Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Non Invasive Technology Inc filed Critical Non Invasive Technology Inc
Priority to JP50521695A priority Critical patent/JP3718224B2/en
Priority to EP94923510A priority patent/EP0708616A4/en
Priority to CA2167179A priority patent/CA2167179C/en
Publication of WO1995002987A2 publication Critical patent/WO1995002987A2/en
Publication of WO1995002987A3 publication Critical patent/WO1995002987A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2889—Rapid scan spectrometers; Time resolved spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1789—Time resolved
    • G01N2021/1791—Time resolved stroboscopic; pulse gated; time range gated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G01N2021/4797—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium time resolved, e.g. analysis of ballistic photons

Abstract

A method and a system (4) for breast tissue examination includes a time-resolved spectroscopy apparatus (20; 20A; 20B), a support (8; 9; 11; 12; 13) with an input port (14) and an output port (16) separated by a selected distance is positioned relative to the examined breast. Locations of the input and output ports are selected to examine a tissue region of the breast. A light source (32; 34; 60) generates pulses of electromagnetic radiation of a selected wavelength in the visible or infrared range. The pulses of duration on the order of a nanosecond or less are introduced into the breast tissue at the input port (14) and detected over time at the detection port (16). Signals corresponding to photons of detected modified pulses are accumulated over time. Values of the scattering coefficient or the absorption coefficient of the examined breast tissue are calculated based on the shape of the modified pulses. The examined breast tissue is characterized based on the values of the scattering coefficient or the absorption coefficient. Absorbing or fluorescing contrast agents may be introduced into the examined tissue. The system may be adapted for use with x-ray mammography, needle localization procedure or MRI mammography.
PCT/US1994/007984 1993-07-16 1994-07-15 Examination of breast tissue using time-resolved spectroscopy WO1995002987A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP50521695A JP3718224B2 (en) 1993-07-16 1994-07-15 Breast tissue inspection device using time-resolved spectroscopy
EP94923510A EP0708616A4 (en) 1993-07-16 1994-07-15 Examination of breast tissue using time-resolved spectroscopy
CA2167179A CA2167179C (en) 1993-07-16 1994-07-15 Examination of breast tissue using time-resolved spectroscopy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/093,208 1993-07-16
US08/093,208 US5555885A (en) 1988-12-21 1993-07-16 Examination of breast tissue using time-resolved spectroscopy

Publications (2)

Publication Number Publication Date
WO1995002987A2 WO1995002987A2 (en) 1995-02-02
WO1995002987A3 true WO1995002987A3 (en) 1995-04-06

Family

ID=22237753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/007984 WO1995002987A2 (en) 1993-07-16 1994-07-15 Examination of breast tissue using time-resolved spectroscopy

Country Status (6)

Country Link
US (2) US5555885A (en)
EP (1) EP0708616A4 (en)
JP (1) JP3718224B2 (en)
CN (1) CN1253127C (en)
CA (1) CA2167179C (en)
WO (1) WO1995002987A2 (en)

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US5348018A (en) * 1991-11-25 1994-09-20 Alfano Robert R Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103340621A (en) * 2013-06-04 2013-10-09 中国科学院苏州生物医学工程技术研究所 Device and method for removing motion artifacts

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JP3718224B2 (en) 2005-11-24
CA2167179A1 (en) 1995-02-02
WO1995002987A2 (en) 1995-02-02
EP0708616A1 (en) 1996-05-01
CA2167179C (en) 2010-04-20
CN1253127C (en) 2006-04-26
JPH09500304A (en) 1997-01-14
EP0708616A4 (en) 1999-03-24
US5899865A (en) 1999-05-04
US5555885A (en) 1996-09-17

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