WO1995015972A1 - Compounds and methods for site-directed mutations in eukaryotic cells - Google Patents
Compounds and methods for site-directed mutations in eukaryotic cells Download PDFInfo
- Publication number
- WO1995015972A1 WO1995015972A1 PCT/US1994/014181 US9414181W WO9515972A1 WO 1995015972 A1 WO1995015972 A1 WO 1995015972A1 US 9414181 W US9414181 W US 9414181W WO 9515972 A1 WO9515972 A1 WO 9515972A1
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- Prior art keywords
- duplex
- nucleic acid
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- chimeric
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Environmental Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT95905337T ATE196311T1 (en) | 1993-12-09 | 1994-12-09 | COMPOUNDS AND METHODS FOR SITE-SPECIFIC MUTATION IN EUKARYOTIC CELLS |
EP95905337A EP0733059B1 (en) | 1993-12-09 | 1994-12-09 | Compounds and methods for site-directed mutations in eukaryotic cells |
DK95905337T DK0733059T3 (en) | 1993-12-09 | 1994-12-09 | Compounds and Methods for Site-directed Mutations in Eukaryotic Cells |
JP51636795A JP3585238B2 (en) | 1993-12-09 | 1994-12-09 | Compounds and methods for site-directed mutagenesis in eukaryotic cells |
DE0733059T DE733059T1 (en) | 1993-12-09 | 1994-12-09 | CONNECTIONS AND METHOD FOR LOCATION-SPECIFIC MUTATION IN EUKARYOTIC CELLS |
NZ278490A NZ278490A (en) | 1993-12-09 | 1994-12-09 | Chimeric polynucleotide with both ribo- and deoxyribonucleotides in one strand and deoxyribonucleotides in a second strand |
AU13995/95A AU691550B2 (en) | 1993-12-09 | 1994-12-09 | Compounds and methods for site-directed mutations in eukaryotic cells |
DE69425903T DE69425903T2 (en) | 1993-12-09 | 1994-12-09 | CONNECTIONS AND METHOD FOR LOCATION-SPECIFIC MUTATION IN EUKARYOTIC CELLS |
GR20000402677T GR3034988T3 (en) | 1993-12-09 | 2000-12-04 | Compounds and methods for site-directed mutations in eukaryotic cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16430393A | 1993-12-09 | 1993-12-09 | |
US164,303 | 1993-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995015972A1 true WO1995015972A1 (en) | 1995-06-15 |
Family
ID=22593886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/014181 WO1995015972A1 (en) | 1993-12-09 | 1994-12-09 | Compounds and methods for site-directed mutations in eukaryotic cells |
Country Status (15)
Country | Link |
---|---|
US (3) | US5565350A (en) |
EP (1) | EP0733059B1 (en) |
JP (1) | JP3585238B2 (en) |
KR (1) | KR100386337B1 (en) |
CN (2) | CN1048254C (en) |
AT (1) | ATE196311T1 (en) |
AU (1) | AU691550B2 (en) |
CA (1) | CA2178729A1 (en) |
DE (2) | DE69425903T2 (en) |
DK (1) | DK0733059T3 (en) |
ES (1) | ES2149962T3 (en) |
GR (1) | GR3034988T3 (en) |
NZ (1) | NZ278490A (en) |
PT (1) | PT733059E (en) |
WO (1) | WO1995015972A1 (en) |
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WO1997041141A1 (en) * | 1996-05-01 | 1997-11-06 | Thomas Jefferson University | Methods and compounds for curing diseases caused by mutations |
WO1998039353A1 (en) * | 1997-03-03 | 1998-09-11 | The Perkin-Elmer Corporation | Improved chimeric oligonucleotide vectors |
WO1998054330A1 (en) * | 1997-05-28 | 1998-12-03 | Zeneca Limited | Methods of in situ modification of plant genes |
WO1999025853A1 (en) * | 1997-11-18 | 1999-05-27 | Pioneer Hi-Bred International, Inc. | Targeted manipulation of herbicide-resistance genes in plants |
EP0945507A1 (en) * | 1998-03-27 | 1999-09-29 | Boehringer Mannheim Gmbh | Tumor specific expression controll region and its use |
EP0968224A1 (en) * | 1996-06-17 | 2000-01-05 | Thomas Jefferson University | Chimeric mutational vectors having non-natural nucleotides |
WO2000028052A2 (en) | 1998-11-09 | 2000-05-18 | Planttec Biotechnologie Gmbh | Nucleic acid molecules from rice encoding an r1 protein and their use for the production of modified starch |
EP1007712A1 (en) * | 1997-08-05 | 2000-06-14 | Kimeragen Inc. | The use of mixed duplex oligonucleotides to effect localized genetic changes in plants |
WO2000042561A2 (en) * | 1999-01-19 | 2000-07-20 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
WO2001025460A2 (en) * | 1999-10-07 | 2001-04-12 | Valigen, Inc. | Compositions and methods for plant genetic modification |
US6319714B1 (en) | 1999-01-19 | 2001-11-20 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6458594B1 (en) | 1997-11-18 | 2002-10-01 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the targeted removal of a nucleotide sequence from the genome of a plant |
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US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7102055B1 (en) | 1997-11-18 | 2006-09-05 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant |
US7247769B2 (en) | 1998-07-31 | 2007-07-24 | Bayer Cropscience Gmbh | Plants synthesizing a modified starch, a process for the generation of the plants, their use, and the modified starch |
EP1925672A1 (en) | 2001-06-22 | 2008-05-28 | Syngeta Participations AG | Abiotic stress responsive polynucleotides and polypeptides |
US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US7560622B2 (en) | 2000-10-06 | 2009-07-14 | Pioneer Hi-Bred International, Inc. | Methods and compositions relating to the generation of partially transgenic organisms |
US7714186B2 (en) | 2002-12-19 | 2010-05-11 | Bayer Cropscience Ag | Plant cells and plants which synthesize a starch with an increased final viscosity |
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US8029988B2 (en) | 1999-01-19 | 2011-10-04 | Codexis Mayflower Holdings, Llc | Oligonucleotide mediated nucleic acid recombination |
US8148517B2 (en) | 2005-04-01 | 2012-04-03 | Bayer Cropscience Ag | Phosphorylated waxy potato starch |
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Also Published As
Publication number | Publication date |
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EP0733059B1 (en) | 2000-09-13 |
GR3034988T3 (en) | 2001-03-30 |
KR960706500A (en) | 1996-12-09 |
US5565350A (en) | 1996-10-15 |
US5756325A (en) | 1998-05-26 |
PT733059E (en) | 2001-03-30 |
ES2149962T3 (en) | 2000-11-16 |
AU1399595A (en) | 1995-06-27 |
KR100386337B1 (en) | 2004-03-24 |
DE69425903T2 (en) | 2001-02-15 |
EP0733059A4 (en) | 1997-05-21 |
DE69425903D1 (en) | 2000-10-19 |
JPH09506511A (en) | 1997-06-30 |
EP0733059A1 (en) | 1996-09-25 |
DK0733059T3 (en) | 2000-10-16 |
US5871984A (en) | 1999-02-16 |
ATE196311T1 (en) | 2000-09-15 |
DE733059T1 (en) | 1997-08-28 |
CN1142829A (en) | 1997-02-12 |
NZ278490A (en) | 1998-03-25 |
AU691550B2 (en) | 1998-05-21 |
CA2178729A1 (en) | 1995-06-15 |
CN1048254C (en) | 2000-01-12 |
JP3585238B2 (en) | 2004-11-04 |
CN1117866C (en) | 2003-08-13 |
CN1215755A (en) | 1999-05-05 |
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