WO1995019638A3 - Ion spray with intersecting flow - Google Patents

Ion spray with intersecting flow Download PDF

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Publication number
WO1995019638A3
WO1995019638A3 PCT/CA1995/000014 CA9500014W WO9519638A3 WO 1995019638 A3 WO1995019638 A3 WO 1995019638A3 CA 9500014 W CA9500014 W CA 9500014W WO 9519638 A3 WO9519638 A3 WO 9519638A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow
orifice
ions
gas
droplets
Prior art date
Application number
PCT/CA1995/000014
Other languages
French (fr)
Other versions
WO1995019638A2 (en
Inventor
Thomas R Covey
Joseph F Anacleto
Original Assignee
Mds Health Group Ltd
Thomas R Covey
Joseph F Anacleto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Health Group Ltd, Thomas R Covey, Joseph F Anacleto filed Critical Mds Health Group Ltd
Priority to DE69509359T priority Critical patent/DE69509359T2/en
Priority to EP95905498A priority patent/EP0739533B1/en
Priority to CA002181040A priority patent/CA2181040C/en
Priority to AU14102/95A priority patent/AU1410295A/en
Publication of WO1995019638A2 publication Critical patent/WO1995019638A2/en
Publication of WO1995019638A3 publication Critical patent/WO1995019638A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7246—Nebulising, aerosol formation or ionisation by pneumatic means
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0477—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample using a hot fluid

Abstract

Liquid from a liquid chromatograph or other sample source, preferably assisted by a high velocity coaxial gas jet, is sprayed through a capillary tube (40') producing a flow in a first direction of charged droplets (50'). A flow of heated gas (60), in a second direction different from the first direction, intersects the droplet flow at a region (64) upstream of an orifice (20'). The flows mix turbulently, with the second flow helping to evaporate the droplets to produce ions and helping to move the evaporating droplets toward the orifice (20'), providing a focusing effect. Ions are drawn through the orifice (20') into a mass analyzer and analyzed. Alternatively the flows of liquid and heating gas can be directed toward each other and at right angles to the axis through the orifice, and the inhaling effect of the orifice can be used to draw droplets toward it, or a third gas flow can be used for this purpose. The heated intersecting gas flow typically provides an increase in sensitivity (ion counts per second) of between 10 and 100 times. Heating the droplet plume also allows controlled desaturation of ions and an increase in the number of charges on them, without degrading the ions.
PCT/CA1995/000014 1994-01-13 1995-01-09 Ion spray with intersecting flow WO1995019638A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE69509359T DE69509359T2 (en) 1994-01-13 1995-01-09 ARYL-SUBSTITUTED 5.5 CONDENSED AROMATIC NITROGEN COMPOUNDS AS AN ANTI-INFLAMMATORY AGENT
EP95905498A EP0739533B1 (en) 1994-01-13 1995-01-09 Ion spray with intersecting flow
CA002181040A CA2181040C (en) 1994-01-13 1995-01-09 Ion spray with intersecting flow
AU14102/95A AU1410295A (en) 1994-01-13 1995-01-09 Ion spray with intersecting flow

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/181,529 US5412208A (en) 1994-01-13 1994-01-13 Ion spray with intersecting flow
US08/181,529 1994-01-13

Publications (2)

Publication Number Publication Date
WO1995019638A2 WO1995019638A2 (en) 1995-07-20
WO1995019638A3 true WO1995019638A3 (en) 1995-10-26

Family

ID=22664672

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000014 WO1995019638A2 (en) 1994-01-13 1995-01-09 Ion spray with intersecting flow

Country Status (6)

Country Link
US (1) US5412208A (en)
EP (1) EP0739533B1 (en)
AU (1) AU1410295A (en)
CA (1) CA2181040C (en)
DE (1) DE69509359T2 (en)
WO (1) WO1995019638A2 (en)

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Also Published As

Publication number Publication date
AU1410295A (en) 1995-08-01
EP0739533A1 (en) 1996-10-30
DE69509359T2 (en) 1999-10-14
CA2181040C (en) 2004-09-21
EP0739533B1 (en) 1999-04-28
US5412208A (en) 1995-05-02
DE69509359D1 (en) 1999-06-02
CA2181040A1 (en) 1995-07-20
WO1995019638A2 (en) 1995-07-20

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