WO1996006620A3 - Lipid analogs for treating viral infections - Google Patents
Lipid analogs for treating viral infections Download PDFInfo
- Publication number
- WO1996006620A3 WO1996006620A3 PCT/US1995/010111 US9510111W WO9606620A3 WO 1996006620 A3 WO1996006620 A3 WO 1996006620A3 US 9510111 W US9510111 W US 9510111W WO 9606620 A3 WO9606620 A3 WO 9606620A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- viral infections
- treating viral
- lipid analogs
- phospholipid
- analogs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95928365A EP0781138B1 (en) | 1994-08-29 | 1995-08-07 | Lipid analogs for treating viral infections |
JP50877396A JP4259611B2 (en) | 1994-08-29 | 1995-08-07 | Lipid analogues for treating viral infections |
DE69535758T DE69535758D1 (en) | 1994-08-29 | 1995-08-07 | LIPID ANALOGUE FOR THE TREATMENT OF VIRAL INFECTIONS |
AU32166/95A AU3216695A (en) | 1994-08-29 | 1995-08-07 | Lipid analogs for treating viral infections |
CA002197319A CA2197319C (en) | 1994-08-29 | 1995-08-07 | Lipid analogs for treating viral infections |
US08/793,470 US5962437A (en) | 1994-08-29 | 1995-08-07 | Lipid analogs for treating viral infections |
US09/412,539 US7129227B1 (en) | 1994-08-29 | 1999-10-04 | Lipid analogs for treating viral infections |
US10/889,127 US7135584B2 (en) | 1995-08-07 | 2004-07-13 | Lipid analogs for treating viral infections |
US10/943,923 US7141557B2 (en) | 1994-08-29 | 2004-09-20 | Lipid analogs for treating viral infections |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29741694A | 1994-08-29 | 1994-08-29 | |
US08/297,416 | 1994-08-29 | ||
US31490194A | 1994-09-29 | 1994-09-29 | |
US08/314,901 | 1994-09-29 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US31490194A Continuation | 1994-08-29 | 1994-09-29 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/793,470 A-371-Of-International US5962437A (en) | 1994-08-29 | 1995-08-07 | Lipid analogs for treating viral infections |
US08793470 A-371-Of-International | 1995-08-07 | ||
US09/412,539 Division US7129227B1 (en) | 1994-08-29 | 1999-10-04 | Lipid analogs for treating viral infections |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996006620A2 WO1996006620A2 (en) | 1996-03-07 |
WO1996006620A3 true WO1996006620A3 (en) | 1996-06-13 |
Family
ID=26970138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/010111 WO1996006620A2 (en) | 1994-08-29 | 1995-08-07 | Lipid analogs for treating viral infections |
Country Status (8)
Country | Link |
---|---|
US (6) | US5962437A (en) |
EP (2) | EP0781138B1 (en) |
JP (3) | JP4259611B2 (en) |
AT (1) | ATE395922T1 (en) |
AU (1) | AU3216695A (en) |
CA (1) | CA2197319C (en) |
DE (1) | DE69535758D1 (en) |
WO (1) | WO1996006620A2 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7135584B2 (en) * | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
EP0781138B1 (en) * | 1994-08-29 | 2008-05-21 | Wake Forest University | Lipid analogs for treating viral infections |
DE19855963A1 (en) * | 1998-12-04 | 2000-06-08 | Herbert Schott | Amphiphilic glyceryl nucleotides, process for their preparation and their use |
US6670341B1 (en) * | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
US7309696B2 (en) * | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
US8071740B2 (en) * | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US6838452B2 (en) * | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
WO2003013573A1 (en) * | 2001-08-10 | 2003-02-20 | Epix Medical, Inc. | Polypeptide conjugates with extended circulating half-lives |
US7125568B2 (en) | 2001-08-23 | 2006-10-24 | Sung Michael T | Lipophilic drug compositions |
KR100871648B1 (en) | 2001-08-31 | 2008-12-03 | 톰슨 라이센싱 | Method of transmitting content, and method and apparatus for receiving and processing content |
EP1436313B1 (en) | 2001-10-19 | 2010-09-22 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
TWI342873B (en) * | 2004-02-04 | 2011-06-01 | Univ Kanagawa | Calixarene compound, method for menufacturing same, intermediate of same, and composition containing same |
US20050187191A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Louis S. | Methods and compositions for the treatment of respiratory syncytial virus |
US20050187192A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Pharmaceutical Company | Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses |
LT2574341T (en) | 2004-03-29 | 2017-09-11 | University Of South Florida | Effective treatment of tumors and cancer with triciribine phosphate |
US7807847B2 (en) | 2004-07-09 | 2010-10-05 | Vascular Biogenics Ltd. | Process for the preparation of oxidized phospholipids |
US20070003608A1 (en) * | 2005-04-08 | 2007-01-04 | Almond Merrick R | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
JP2008535862A (en) * | 2005-04-08 | 2008-09-04 | キメリクス,インコーポレイテッド | Compounds, compositions and methods for the treatment of poxvirus infections |
JP5320284B2 (en) | 2006-05-03 | 2013-10-23 | キメリクス,インコーポレーテッド | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
US8569529B2 (en) | 2007-01-09 | 2013-10-29 | Vascular Biogenics Ltd. | High-purity phospholipids |
US9006217B2 (en) | 2007-01-09 | 2015-04-14 | Vascular Biogenics Ltd. | High-purity phospholipids |
EP2596799B1 (en) | 2007-02-08 | 2016-11-23 | University of Utah Research Foundation | Methods and compositions related to inhibition of viral entry |
EP2070938A1 (en) | 2007-12-13 | 2009-06-17 | Heidelberg Pharma AG | Clofarabine dietherphospholipid derivatives |
MX2010008148A (en) * | 2008-01-25 | 2010-10-20 | Chimerix Inc | Methods of treating viral infections. |
JP5752599B2 (en) * | 2008-11-06 | 2015-07-22 | ヴァスキュラー バイオジェニックス リミテッド | Oxidized lipid compounds and uses thereof |
US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
EP3216789A1 (en) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Methods of treating viral infection |
EP2563367A4 (en) | 2010-04-26 | 2013-12-04 | Chimerix Inc | Methods of treating retroviral infections and related dosage regimes |
CA2868735C (en) * | 2011-03-28 | 2020-02-25 | University Of Utah Research Foundation | D-peptide conjugates comprising a membrane localizing potency-enhancing cargo molecule for inhibiting hiv entry |
JP6717825B2 (en) | 2014-11-26 | 2020-07-08 | バスキュラー バイオジェニックス リミテッド | Oxidized lipids and methods for treating or preventing fibrosis |
US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
CA3010713A1 (en) | 2016-01-07 | 2017-07-13 | Navigen, Inc. | D-peptide inhibitors of hiv entry and methods of use |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3934820A1 (en) * | 1989-10-19 | 1991-04-25 | Boehringer Mannheim Gmbh | USE OF LECITHIN ANALOGA AS AN ANTIVIRAL MEDICINAL PRODUCT AND NEW DERIVATIVES |
WO1991009602A2 (en) * | 1989-12-23 | 1991-07-11 | Boehringer Mannheim Gmbh | Use of alkyl phospholipids as antiviral drugs, as well as new compounds |
DE4010228A1 (en) * | 1990-03-30 | 1991-10-02 | Werner E G Prof Dr Mueller | Prepn. of antiviral, esp. anti-AIDS agent - by mixing halo-contg. higher alkyl-glycerol-phospho-choline analogues with suitable carrier |
Family Cites Families (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2108765A (en) * | 1938-02-15 | Preserving and disinfecting media | ||
US2086585A (en) * | 1933-04-13 | 1937-07-13 | Alba Pharmaceutical Company In | Quaternary ammonium compounds |
US2087132A (en) * | 1933-04-13 | 1937-07-13 | Alba Pharmaceutical Company In | Quaternary ammonium compounds |
US2209383A (en) * | 1938-03-05 | 1940-07-30 | Rohm & Haas | Process of waterproofing fabrics |
US2445393A (en) * | 1944-03-08 | 1948-07-20 | Rhone Poulenc Sa | New amino-derivatives of dioxa-cyclopentane |
US2439969A (en) * | 1944-04-17 | 1948-04-20 | Rhone Poulenc Sa | Amino-dioxacyclopentanes |
US2513747A (en) * | 1945-10-04 | 1950-07-04 | Ciba Ltd | Cyclic amino-acetals |
US2606909A (en) * | 1947-08-01 | 1952-08-12 | Univ Michigan | Basic dioxolanes |
US2689790A (en) * | 1951-09-26 | 1954-09-21 | Monsanto Chemicals | Nitrogenous compound herbicides |
NL189533C (en) * | 1953-07-29 | Ates Componenti Elettron | PROCEDURE FOR APPLYING A PLASTIC HOLDER WITH HEAT DISCHARGE AROUND AN INTEGRATED CIRCUIT, AS WELL AS COMBINATION OF A MOLD AND A HEAT DISCHARGE ELEMENT FOR USE IN THIS PROCEDURE. | |
US3054678A (en) * | 1958-04-16 | 1962-09-18 | Michener Harold David | Preservation process with quaternary ammonium compounds |
DE1619043B2 (en) * | 1967-04-07 | 1977-11-03 | Hoechst Ag, 6000 Frankfurt | AGENT FOR SOFTENING TEXTILES AND AT THE SAME TIME PROVIDING GOOD ABSORPTION |
US4119714A (en) * | 1970-02-27 | 1978-10-10 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. | Glycerin-alkylether-(1)-phosphoric acid-(3)-monocholine esters as enhancers of the natural resistance of the mammalian organism against non-carcinogenic pathogens |
DE2033359C3 (en) * | 1970-07-06 | 1980-02-14 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Acylpropanediol- (1,3) -phosphoric acid monocholine ester and process for their preparation |
JPS49100224A (en) * | 1973-01-29 | 1974-09-21 | ||
US4093714A (en) * | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
US4159988A (en) * | 1974-08-06 | 1979-07-03 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Synthetic phospholipids, a process for their manufacture and their use |
FR2356425A1 (en) * | 1976-07-01 | 1978-01-27 | Roussel Uclaf | APPLICATION AS MEDICINAL PRODUCTS FROM ORGANIC DERIVATIVES OF MONTMORILLONITE |
US4291024A (en) | 1978-04-10 | 1981-09-22 | Turcotte Joseph G | Cytotoxic liponucleotide analogs |
DE2820893C2 (en) | 1978-05-12 | 1986-02-20 | A. Nattermann & Cie GmbH, 5000 Köln | Structural analogs of natural phospholipids and processes for making these compounds |
US4235877A (en) * | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US4329302A (en) * | 1980-06-27 | 1982-05-11 | Board Of Regents, The University Of Texas System | Synthetic phosphoglycerides possessing platelet activating properties |
US4444766A (en) * | 1980-10-21 | 1984-04-24 | Boehringer Mannheim Gmbh | Sulfur-containing phospholipid compounds and therapeutic compositions |
DE3039629A1 (en) * | 1980-10-21 | 1982-06-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Alkanol phosphoric acid mono-ammonium alkyl ester(s) - are cancerostatic phospholipid(s) which do not cause thrombocyte aggregation |
JPS5772914A (en) * | 1980-10-22 | 1982-05-07 | Takeda Chem Ind Ltd | Antitumor agent |
US4471113A (en) * | 1982-02-03 | 1984-09-11 | The United States Of America As Represented By The Department Of Energy | Prodrugs based on phospholipid-nucleoside conjugates |
EP0094586A3 (en) * | 1982-05-13 | 1984-06-06 | Ono Pharmaceutical Co., Ltd. | Glycerol derivatives, process for preparing same and pharmaceutical composition containing same |
US4661509A (en) * | 1982-09-28 | 1987-04-28 | Gordon Arnold Z | Methods for treating leukopenia |
JPS5988447A (en) * | 1982-11-11 | 1984-05-22 | Ono Pharmaceut Co Ltd | Glycerol derivative, its production and agent containing said derivative |
FR2540122B1 (en) * | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | NOVEL COMPOUNDS COMPRISING A SEQUENCE OF OLIGONUCLEOTIDE LINKED TO AN INTERCALATION AGENT, THEIR SYNTHESIS PROCESS AND THEIR APPLICATION |
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (en) | 1983-08-30 | 1985-04-24 | Oreal | COSMETIC OR PHARMACEUTICAL COMPOSITION IN AQUEOUS OR ANHYDROUS FORM WHOSE FATTY PHASE CONTAINS OLIGOMER POLYETHER AND NEW OLIGOMER POLYETHERS |
JPS6081193A (en) * | 1983-10-11 | 1985-05-09 | Takeda Chem Ind Ltd | Phospholipid |
JPS60100544A (en) * | 1983-11-08 | 1985-06-04 | Ono Pharmaceut Co Ltd | Novel glycerin derivative, its preparation and drug containing it |
JPS60104066A (en) * | 1983-11-10 | 1985-06-08 | Ono Pharmaceut Co Ltd | Glycerin derivative, its preparation, and drug containing it |
JPS60105650A (en) * | 1983-11-14 | 1985-06-11 | Ono Pharmaceut Co Ltd | Glycerol derivative, production thereof and pharmaceutical containing said derivative |
US4540521A (en) * | 1984-01-16 | 1985-09-10 | National Distillers And Chemical Corporation | Liquid quaternary ammonium antistatic compositions |
US4622392A (en) | 1984-06-21 | 1986-11-11 | Health Research Inc. (Roswell Park Division) | Thiophospholipid conjugates of antitumor agents |
JPS6124519A (en) * | 1984-07-11 | 1986-02-03 | Takeda Chem Ind Ltd | Antitumor agent |
US4826823A (en) * | 1985-02-05 | 1989-05-02 | Warner-Lambert Company | Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts |
US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
US4724232A (en) | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
FR2580283B1 (en) | 1985-04-15 | 1989-11-24 | Toyo Jozo Kk | NEW NUCLEOSIDE-PHOSPHOLIPIDE CONJUGATE |
JPS61238793A (en) | 1985-04-17 | 1986-10-24 | Toyo Jozo Co Ltd | Novel phospholipid derivative |
US4619917A (en) * | 1985-07-18 | 1986-10-28 | Sandoz Pharm. Corp. | Substituted 2-furanyl- or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts |
CA1280369C (en) * | 1985-12-04 | 1991-02-19 | Hansjorg Eibl | Pharmaceutical with anti-tumor effect |
US4841039A (en) * | 1986-05-01 | 1989-06-20 | Emory University | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents |
DE3619748A1 (en) * | 1986-06-12 | 1987-12-17 | Merz & Co Gmbh & Co | ANTIMICROBIAL AGENTS |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
EP0262876B1 (en) | 1986-09-27 | 1992-04-29 | Toyo Jozo Kabushiki Kaisha | Nucleoside-phospholipid conjugate |
US4880782A (en) * | 1986-11-21 | 1989-11-14 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. | Method of treating viral infections in humans and compositions therefor |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
JPS6429319A (en) * | 1987-07-23 | 1989-01-31 | Toyama Chemical Co Ltd | Antiviral agent containing lysolecithin and phospholipid |
DE3726945A1 (en) * | 1987-08-13 | 1989-02-23 | Dietl Hans | L-Carnitine derivatives of valproic acid and pharmaceuticals containing these |
US4894389A (en) * | 1987-10-02 | 1990-01-16 | Merrell Dow Pharmaceuticals Inc. | Novel aminoalkyl-substituted heterocyclic sulfur compounds |
US4997761A (en) | 1987-10-06 | 1991-03-05 | Houston Biotechnology Incorporated | Phosphatidyl treatment of viral disease |
EP0335396A1 (en) * | 1988-04-01 | 1989-10-04 | MAGIS FARMACEUTICI S.p.A. | Glycero-phosphoric and -diphosphoric acids derivatives of L-carnitine or L-carnitine esters |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
JPH01293129A (en) | 1988-05-20 | 1989-11-27 | Kobe Steel Ltd | Continuous high temperature and high pressure treatment device |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
EP0348859A1 (en) * | 1988-07-01 | 1990-01-03 | MAGIS FARMACEUTICI S.p.A. | 1,2-di-O-acyl glycero(DI)phosphate of L-carnitine and its derivatives, a process for their preparation and pharmaceutical formulations which contain them |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
CA2001401A1 (en) | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
GB8827337D0 (en) * | 1988-11-23 | 1988-12-29 | Medical Res Council | Nucleoside analogues |
US5221696A (en) | 1989-03-29 | 1993-06-22 | Alcon Laboratories, Inc. | Use of monoacyl phosphoglycerides to enhance the corneal penetration of ophthalmic drugs |
FI902821A0 (en) * | 1989-06-12 | 1990-06-06 | Res Found Mental Hygiene | FOERMINSKNING AV INFEKTIONSSPRIDNING MEDELST BLODBEHANDLINGSAPPARATUR. |
DE3929217A1 (en) * | 1989-09-02 | 1991-03-07 | Boehringer Mannheim Gmbh | USE OF PHOSPHOLIPID DERIVATIVES AS ANTIVIRAL MEDICINAL PRODUCTS AND NEW PHOSPHOLIPIDES |
GR1000688B (en) * | 1989-12-22 | 1992-10-08 | Sod Conseils Rech Applic | Glycerine derivatives preparation method |
MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
GB2239243B (en) | 1989-12-22 | 1993-05-12 | Scras | Glycerol derivatives |
US5026687A (en) | 1990-01-03 | 1991-06-25 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds |
EP0531452A4 (en) * | 1990-05-29 | 1993-06-09 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
ATE137242T1 (en) * | 1990-06-15 | 1996-05-15 | Univ Wake Forest | COVALENT-THER LIPIDENUCLEOSIDE CONJUGATES |
US5138045A (en) * | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
DE4026265A1 (en) * | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PRODUCTION AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS |
WO1992004887A1 (en) * | 1990-09-25 | 1992-04-02 | Kyowa Hakko Kogyo Co., Ltd. | Induction of cytotoxic t cell |
CA2093816A1 (en) * | 1990-10-09 | 1992-04-10 | Michael J. Scolaro | Inhibition of viral replication |
EP0594677A4 (en) | 1991-07-12 | 1997-09-17 | Vical Inc | Antiviral liponucleosides: treatment of hepatitis b |
CA2122246C (en) * | 1991-10-28 | 1999-04-27 | Dennis L. Fost | Phospholipid antimicrobial compositions |
DE4204031A1 (en) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | NEW LIPID PHOSPHONIC ACID-NUCLEOSIDE CONJUGATES AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS |
DE4204032A1 (en) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | NEW LIPONUCLEOTIDES, THEIR PRODUCTION AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS |
GB9204015D0 (en) * | 1992-02-25 | 1992-04-08 | Wellcome Found | Therapeutic nucleosides |
US6602861B1 (en) * | 1992-04-16 | 2003-08-05 | Research Corporation Technologies, Inc. | Acylated phospholipid drugs |
US5512671A (en) | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
WO1994019012A2 (en) | 1993-02-24 | 1994-09-01 | Wang Jui H | Compositions and methods of application of reactive antiviral polymers |
IL105244A (en) | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
US6413949B1 (en) | 1995-06-07 | 2002-07-02 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
WO1994028908A2 (en) | 1993-06-10 | 1994-12-22 | Wake Forest University | (phospho)lipids for combatting hepatitis b virus infection |
ATE199906T1 (en) * | 1993-06-29 | 2001-04-15 | Mitsubishi Chem Corp | PHOSPHONATE NUCLEOTIDE ESTER DERIVATIVES |
CA2167537A1 (en) | 1993-07-19 | 1995-02-02 | Tsuneo Ozeki | Hepatitis c virus proliferation inhibitor |
EP0781138B1 (en) * | 1994-08-29 | 2008-05-21 | Wake Forest University | Lipid analogs for treating viral infections |
JP3786447B2 (en) | 1995-03-31 | 2006-06-14 | エーザイ株式会社 | Preventive and therapeutic agent for hepatitis C |
US5633388A (en) | 1996-03-29 | 1997-05-27 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
US5830905A (en) | 1996-03-29 | 1998-11-03 | Viropharma Incorporated | Compounds, compositions and methods for treatment of hepatitis C |
US5891874A (en) | 1996-06-05 | 1999-04-06 | Eli Lilly And Company | Anti-viral compound |
JP3927630B2 (en) | 1996-09-27 | 2007-06-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Preventive and therapeutic agents for viral infections |
US5922757A (en) | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
JPH10293129A (en) | 1997-04-18 | 1998-11-04 | Nof Corp | Method for measuring endotoxin in phospholipid |
EP1009732B1 (en) | 1997-06-30 | 2003-05-21 | MERZ + CO. GmbH & Co. | 1-amino-alkylcyclohexane nmda receptor antagonists |
GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
US6670341B1 (en) | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
JP4213841B2 (en) | 2000-03-23 | 2009-01-21 | 大成建設株式会社 | Temporary bearing construction method |
PT1241432E (en) | 2001-03-15 | 2006-12-29 | Teijin Twaron Gmbh | Penetration-resistant material comprising fabric with high linear density ratio of two sets of threads |
-
1995
- 1995-08-07 EP EP95928365A patent/EP0781138B1/en not_active Expired - Lifetime
- 1995-08-07 AU AU32166/95A patent/AU3216695A/en not_active Abandoned
- 1995-08-07 WO PCT/US1995/010111 patent/WO1996006620A2/en active Application Filing
- 1995-08-07 DE DE69535758T patent/DE69535758D1/en not_active Expired - Fee Related
- 1995-08-07 US US08/793,470 patent/US5962437A/en not_active Expired - Fee Related
- 1995-08-07 CA CA002197319A patent/CA2197319C/en not_active Expired - Fee Related
- 1995-08-07 EP EP07016369A patent/EP1852121A3/en not_active Withdrawn
- 1995-08-07 AT AT95928365T patent/ATE395922T1/en not_active IP Right Cessation
- 1995-08-07 JP JP50877396A patent/JP4259611B2/en not_active Expired - Fee Related
-
1999
- 1999-10-04 US US09/412,539 patent/US7129227B1/en not_active Expired - Fee Related
-
2004
- 2004-09-20 US US10/943,923 patent/US7141557B2/en not_active Expired - Fee Related
-
2006
- 2006-10-11 JP JP2006278049A patent/JP2007056033A/en active Pending
- 2006-10-27 US US11/588,311 patent/US7294620B2/en not_active Expired - Fee Related
- 2006-10-27 US US11/588,313 patent/US7294621B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/980,819 patent/US8106032B2/en not_active Expired - Fee Related
-
2010
- 2010-10-18 JP JP2010233427A patent/JP2011051996A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3934820A1 (en) * | 1989-10-19 | 1991-04-25 | Boehringer Mannheim Gmbh | USE OF LECITHIN ANALOGA AS AN ANTIVIRAL MEDICINAL PRODUCT AND NEW DERIVATIVES |
WO1991009602A2 (en) * | 1989-12-23 | 1991-07-11 | Boehringer Mannheim Gmbh | Use of alkyl phospholipids as antiviral drugs, as well as new compounds |
DE4010228A1 (en) * | 1990-03-30 | 1991-10-02 | Werner E G Prof Dr Mueller | Prepn. of antiviral, esp. anti-AIDS agent - by mixing halo-contg. higher alkyl-glycerol-phospho-choline analogues with suitable carrier |
Non-Patent Citations (2)
Title |
---|
"In vitro evaluation of phosphocholine and quaternary ammonium containing lipids as novel anti-HIV agents", J.MED.CHEM., vol. 34, no. 4, pages 1377 - 83 * |
"Membrane interactive phospholipids inhibit HIV type 1-induced cell fusion and surface gp160/gp 120 binding to monoclonal antibody", AIDS RES. HUM. RETROVIRUSES, vol. 11, no. 6, pages 705 - 712 * |
Also Published As
Publication number | Publication date |
---|---|
US7294620B2 (en) | 2007-11-13 |
JP2011051996A (en) | 2011-03-17 |
JP2007056033A (en) | 2007-03-08 |
JP4259611B2 (en) | 2009-04-30 |
US20050080050A1 (en) | 2005-04-14 |
DE69535758D1 (en) | 2008-07-03 |
US8106032B2 (en) | 2012-01-31 |
EP1852121A2 (en) | 2007-11-07 |
US20070099870A1 (en) | 2007-05-03 |
EP0781138A2 (en) | 1997-07-02 |
US7141557B2 (en) | 2006-11-28 |
AU3216695A (en) | 1996-03-22 |
US7294621B2 (en) | 2007-11-13 |
CA2197319A1 (en) | 1996-03-07 |
WO1996006620A2 (en) | 1996-03-07 |
ATE395922T1 (en) | 2008-06-15 |
EP1852121A3 (en) | 2007-11-21 |
JPH10506619A (en) | 1998-06-30 |
US7129227B1 (en) | 2006-10-31 |
EP0781138B1 (en) | 2008-05-21 |
CA2197319C (en) | 2009-01-27 |
US20080293667A1 (en) | 2008-11-27 |
US20070105812A1 (en) | 2007-05-10 |
US5962437A (en) | 1999-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1996006620A3 (en) | Lipid analogs for treating viral infections | |
AU7044894A (en) | (phospho)lipids for combatting hepatitis b virus infection | |
WO2001090121A3 (en) | Methods and compositions for treating hepatitis c virus | |
IL153078A0 (en) | Methods for treating hepatitis delta virus infection with beta-l-2' deoxy nucleosides | |
WO2003063771A3 (en) | N4-acylcytosine nucleosides for treatment of viral iinfections | |
UA66744C2 (en) | 5,6-dichlorobenzimidazole derivatives, methods for the preparation thereof, pharmaceutical composition and method for treatment of viral infections | |
PL297849A1 (en) | Vaccine against and method of treating the patients infectedwith hiv virus | |
MY127808A (en) | Use of dideoxy nucleoside analogues in the treatment of viral infections | |
AU3530293A (en) | Compositions for the treatment of infection and disease caused by hepatitis B virus (HBV) | |
HK1041215A1 (en) | Use of thymosin alpha 1 in combination with lamivudine or in combination with lamivudine and famciclovir in manufacturing pharmaceutical combination preparations for treating hepatitis b infection. | |
AU2880595A (en) | Use of pharmaceutical agents for restoring, alleviation, or treatment of immunodeficiency, including the alleviation or treatment of the immune dysfunction related to infection with human immunodeficiency viruses (hiv) or related viruses | |
CA2189705A1 (en) | Use of flupirtine for the prophylaxis and therapy of diseases associated with an impairment of the haematopoetic cell system | |
WO1997026880A3 (en) | Use of a combination of delavirdine and one or more protease inhibitors in hiv-1 infected patients | |
CA2142862A1 (en) | Method for Inhibiting HIV Replication Using IL-4 | |
ES2014042A6 (en) | Composition and method for treating hepatitis virus infections using 1-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)-5-ethyluracil. | |
WO1993014760A3 (en) | Methods | |
AU2396900A (en) | Treatment and prevention of hiv and other viral infections | |
AU3593095A (en) | Method of treatment of human immunodeficiency virus (hiv) infection | |
AU6447690A (en) | Method of administering soluble t4 for treatment of human immunodeficiency virus infection | |
WO1996013263A3 (en) | Methods of treatment of viral disease with inhibitors of sphingolipid biosynthesis | |
AU6247896A (en) | Method for preparing sulphate esters effective in the treatment of hiv (human immunodeficiency virus) infections, and aids |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2197319 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1995928365 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08793470 Country of ref document: US |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1995928365 Country of ref document: EP |