WO1996015814A1 - Preparation of hollow microcapsules - Google Patents
Preparation of hollow microcapsules Download PDFInfo
- Publication number
- WO1996015814A1 WO1996015814A1 PCT/GB1995/002673 GB9502673W WO9615814A1 WO 1996015814 A1 WO1996015814 A1 WO 1996015814A1 GB 9502673 W GB9502673 W GB 9502673W WO 9615814 A1 WO9615814 A1 WO 9615814A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microcapsules
- process according
- protein
- solution
- air
- Prior art date
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- 150000004676 glycans Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960001025 iohexol Drugs 0.000 description 1
- 229960004647 iopamidol Drugs 0.000 description 1
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 description 1
- 229960004537 ioversol Drugs 0.000 description 1
- 229960001707 ioxaglic acid Drugs 0.000 description 1
- TYYBFXNZMFNZJT-UHFFFAOYSA-N ioxaglic acid Chemical compound CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I TYYBFXNZMFNZJT-UHFFFAOYSA-N 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
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- 208000010125 myocardial infarction Diseases 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 210000003492 pulmonary vein Anatomy 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
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- 238000004448 titration Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT95936688T ATE216595T1 (en) | 1994-11-19 | 1995-11-15 | METHOD FOR PRODUCING HOLLOW MICROSPHERES |
DE69526491T DE69526491T3 (en) | 1994-11-19 | 1995-11-15 | PROCESS FOR PRODUCING HOLY MICROSPHAKERS |
DK95936688T DK0743860T3 (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
AU38533/95A AU681815B2 (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
GB9610968A GB2298628B (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
US08/676,344 US5741478A (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules by spray-drying an aqueous solution of a wall-forming material and a water-miscible solvent |
JP51665396A JP4592831B2 (en) | 1994-11-19 | 1995-11-15 | Production of hollow microcapsules |
CA002177492A CA2177492C (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
EP95936688A EP0743860B2 (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
KR1019960703464A KR100188356B1 (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
NO19962994A NO313491B1 (en) | 1994-11-19 | 1996-07-18 | Process for making hollow microspheres |
MXPA/A/1996/002851A MXPA96002851A (en) | 1994-11-19 | 1996-07-18 | Preparation of microcapsules hue |
HK98114794A HK1013405A1 (en) | 1994-11-19 | 1998-12-22 | Preparation of hollow microcapsules |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9423419.2 | 1994-11-19 | ||
GB9423419A GB9423419D0 (en) | 1994-11-19 | 1994-11-19 | Preparation of hollow microcapsules |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/023,696 Division US6623722B1 (en) | 1994-11-19 | 1998-02-13 | Spray-drying microcapsules using an aqueous liquid containing a volatile liquid |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996015814A1 true WO1996015814A1 (en) | 1996-05-30 |
Family
ID=10764705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1995/002673 WO1996015814A1 (en) | 1994-11-19 | 1995-11-15 | Preparation of hollow microcapsules |
Country Status (19)
Country | Link |
---|---|
US (2) | US5741478A (en) |
EP (1) | EP0743860B2 (en) |
JP (1) | JP4592831B2 (en) |
KR (1) | KR100188356B1 (en) |
CN (1) | CN1072966C (en) |
AT (1) | ATE216595T1 (en) |
AU (1) | AU681815B2 (en) |
CA (1) | CA2177492C (en) |
DE (1) | DE69526491T3 (en) |
DK (1) | DK0743860T3 (en) |
ES (1) | ES2174968T3 (en) |
GB (2) | GB9423419D0 (en) |
HK (1) | HK1013405A1 (en) |
NO (1) | NO313491B1 (en) |
PT (1) | PT743860E (en) |
RU (1) | RU2193397C2 (en) |
SG (1) | SG81230A1 (en) |
WO (1) | WO1996015814A1 (en) |
ZA (1) | ZA959801B (en) |
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US5741478A (en) * | 1994-11-19 | 1998-04-21 | Andaris Limited | Preparation of hollow microcapsules by spray-drying an aqueous solution of a wall-forming material and a water-miscible solvent |
WO1998032378A1 (en) | 1997-01-22 | 1998-07-30 | Quadrant Healthcare (Uk) Limited | Ultrasound contrast imaging |
US5961459A (en) * | 1996-10-19 | 1999-10-05 | Andaris Limited | Use of hollow microcapsules in diagnosis and therapy |
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1994
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1995
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- 1995-11-15 CA CA002177492A patent/CA2177492C/en not_active Expired - Fee Related
- 1995-11-15 US US08/676,344 patent/US5741478A/en not_active Expired - Lifetime
- 1995-11-15 CN CN95191282A patent/CN1072966C/en not_active Expired - Fee Related
- 1995-11-15 KR KR1019960703464A patent/KR100188356B1/en not_active IP Right Cessation
- 1995-11-15 AU AU38533/95A patent/AU681815B2/en not_active Ceased
- 1995-11-15 GB GB9610968A patent/GB2298628B/en not_active Expired - Fee Related
- 1995-11-15 DK DK95936688T patent/DK0743860T3/en active
- 1995-11-15 SG SG9800856A patent/SG81230A1/en unknown
- 1995-11-15 EP EP95936688A patent/EP0743860B2/en not_active Expired - Lifetime
- 1995-11-15 PT PT95936688T patent/PT743860E/en unknown
- 1995-11-15 RU RU96116133/14A patent/RU2193397C2/en not_active IP Right Cessation
- 1995-11-15 DE DE69526491T patent/DE69526491T3/en not_active Expired - Lifetime
- 1995-11-15 AT AT95936688T patent/ATE216595T1/en not_active IP Right Cessation
- 1995-11-15 ES ES95936688T patent/ES2174968T3/en not_active Expired - Lifetime
- 1995-11-15 WO PCT/GB1995/002673 patent/WO1996015814A1/en active IP Right Grant
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1996
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1998
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Also Published As
Publication number | Publication date |
---|---|
GB9610968D0 (en) | 1996-07-31 |
ES2174968T3 (en) | 2002-11-16 |
AU681815B2 (en) | 1997-09-04 |
DK0743860T3 (en) | 2002-08-12 |
US5741478A (en) | 1998-04-21 |
EP0743860B2 (en) | 2008-12-31 |
JPH09508067A (en) | 1997-08-19 |
GB2298628B (en) | 1998-08-05 |
NO313491B1 (en) | 2002-10-14 |
CA2177492C (en) | 2003-03-25 |
ATE216595T1 (en) | 2002-05-15 |
EP0743860A1 (en) | 1996-11-27 |
CN1072966C (en) | 2001-10-17 |
PT743860E (en) | 2002-10-31 |
NO962994D0 (en) | 1996-07-18 |
KR100188356B1 (en) | 1999-06-01 |
EP0743860B1 (en) | 2002-04-24 |
JP4592831B2 (en) | 2010-12-08 |
US6623722B1 (en) | 2003-09-23 |
AU3853395A (en) | 1996-06-17 |
CA2177492A1 (en) | 1996-05-30 |
CN1138828A (en) | 1996-12-25 |
DE69526491D1 (en) | 2002-05-29 |
SG81230A1 (en) | 2001-06-19 |
DE69526491T3 (en) | 2009-07-30 |
NO962994L (en) | 1996-07-18 |
HK1013405A1 (en) | 1999-08-27 |
GB9423419D0 (en) | 1995-01-11 |
MX9602851A (en) | 1997-12-31 |
RU2193397C2 (en) | 2002-11-27 |
GB2298628A (en) | 1996-09-11 |
DE69526491T2 (en) | 2002-10-31 |
ZA959801B (en) | 1996-08-28 |
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