WO1996040281A3 - Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients - Google Patents
Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients Download PDFInfo
- Publication number
- WO1996040281A3 WO1996040281A3 PCT/US1996/009068 US9609068W WO9640281A3 WO 1996040281 A3 WO1996040281 A3 WO 1996040281A3 US 9609068 W US9609068 W US 9609068W WO 9640281 A3 WO9640281 A3 WO 9640281A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gas emulsions
- ocf2
- fluorinated ethers
- emulsions stabilized
- low ostwald
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 3
- 150000002170 ethers Chemical class 0.000 title 1
- XZKOELJOFVHXRS-UHFFFAOYSA-N 1,1,1,2,2,3,3-heptafluoro-3-(1,1,2,2,3,3,3-heptafluoropropoxy)propane Chemical compound FC(F)(F)C(F)(F)C(F)(F)OC(F)(F)C(F)(F)C(F)(F)F XZKOELJOFVHXRS-UHFFFAOYSA-N 0.000 abstract 1
- JTPMOHUDFCBCEC-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-1,2-bis(trifluoromethoxy)ethane Chemical compound FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)F JTPMOHUDFCBCEC-UHFFFAOYSA-N 0.000 abstract 1
- YSGKVOMJRCQYMT-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-1-[1,1,2,2-tetrafluoro-2-(trifluoromethoxy)ethoxy]-2-(trifluoromethoxy)ethane Chemical compound FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)F YSGKVOMJRCQYMT-UHFFFAOYSA-N 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000012285 ultrasound imaging Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Acoustics & Sound (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT96918164T ATE216894T1 (en) | 1995-06-07 | 1996-06-05 | GAS EMULSIONS STABILIZED BY FLUORINATED ETHERS WITH LOW OSTWALD COEFFICIENTS |
DE69621015T DE69621015T2 (en) | 1995-06-07 | 1996-06-05 | GAS EMULSIONS STABILIZED BY FLUORINE ETHERS WITH LOW EAST FOREST COEFFICIENTS |
EP96918164A EP0833669B1 (en) | 1995-06-07 | 1996-06-05 | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients |
PL96323868A PL185883B1 (en) | 1995-06-07 | 1996-06-05 | Emulsions of gases stabilise by means of fluorinated ethers of low ostwald coefficient |
DK96918164T DK0833669T3 (en) | 1995-06-07 | 1996-06-05 | Gas emulsions stabilized with fluorinated ethers with low Ostwald coefficients |
IL13534296A IL135342A0 (en) | 1995-06-07 | 1996-06-05 | A microbubble precursor |
AU60487/96A AU712946B2 (en) | 1995-06-07 | 1996-06-05 | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients |
IL12221796A IL122217A (en) | 1995-06-07 | 1996-06-05 | Gas emulsions for ultrasound contrast enhancement stabilized with fluorinated ethers |
JP50147797A JP4067116B2 (en) | 1995-06-07 | 1996-06-05 | Gas emulsion stabilized with fluorinated ether with low Ostwald coefficient |
US08/973,281 US6193952B1 (en) | 1995-06-07 | 1996-06-05 | Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement |
NO975317A NO975317L (en) | 1995-06-07 | 1997-11-19 | Gas emulsions stabilized with fluorinated ethers with low cheese forest coefficients |
US09/746,215 US20020119102A1 (en) | 1996-06-05 | 2000-12-22 | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/479,621 | 1995-06-07 | ||
US08/479,621 US5804162A (en) | 1995-06-07 | 1995-06-07 | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/479,621 Continuation-In-Part US5804162A (en) | 1995-06-07 | 1995-06-07 | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/973,281 Continuation US6193952B1 (en) | 1995-06-07 | 1996-06-05 | Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement |
US08/973,281 A-371-Of-International US6193952B1 (en) | 1995-06-07 | 1996-06-05 | Stabilized gas emulsions containing phospholipid for ultrasound contrast enhancement |
US09/746,215 Continuation US20020119102A1 (en) | 1995-06-07 | 2000-12-22 | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients |
Publications (4)
Publication Number | Publication Date |
---|---|
WO1996040281A2 WO1996040281A2 (en) | 1996-12-19 |
WO1996040281A9 WO1996040281A9 (en) | 1997-02-06 |
WO1996040281A3 true WO1996040281A3 (en) | 1997-03-13 |
WO1996040281B1 WO1996040281B1 (en) | 2001-04-05 |
Family
ID=23904745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/009068 WO1996040281A2 (en) | 1995-06-07 | 1996-06-05 | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients |
Country Status (18)
Country | Link |
---|---|
US (2) | US5804162A (en) |
EP (2) | EP1174153B1 (en) |
JP (1) | JP4067116B2 (en) |
KR (1) | KR100401429B1 (en) |
CN (1) | CN1087954C (en) |
AT (2) | ATE337018T1 (en) |
AU (1) | AU712946B2 (en) |
CA (1) | CA2222186A1 (en) |
CZ (1) | CZ391397A3 (en) |
DE (2) | DE69621015T2 (en) |
DK (1) | DK0833669T3 (en) |
ES (2) | ES2176462T3 (en) |
HU (1) | HUP9900848A3 (en) |
IL (1) | IL122217A (en) |
NO (1) | NO975317L (en) |
PL (1) | PL185883B1 (en) |
PT (1) | PT833669E (en) |
WO (1) | WO1996040281A2 (en) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
DK0711179T3 (en) * | 1993-07-30 | 2005-02-14 | Imcor Pharmaceutical Co | Stabilized ultrasound microbubble compositions |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
ATE345682T1 (en) | 1996-05-01 | 2006-12-15 | Imarx Pharmaceutical Corp | IN VITRO METHOD FOR INTRODUCING NUCLEIC ACIDS INTO A CELL |
IL128057A (en) * | 1996-08-05 | 2001-08-26 | Schering Ag | Process for the production of contrast media |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
DE69737915T2 (en) | 1996-09-11 | 2008-03-13 | Bristol-Myers Squibb Medical Imaging, Inc. | Method of diagnostic imaging of the kidney region using a contrast agent and a vasodilator |
EE03749B1 (en) | 1996-10-21 | 2002-06-17 | Nycomed Imaging As | Combination preparation for simultaneous, separate or sequential use as a contrast agent in ultrasound imaging |
WO1998023298A1 (en) * | 1996-11-25 | 1998-06-04 | Imarx Pharmaceutical Corp. | Perfluorinated-ether compositions as diagnostic contrast agents |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
US20020039594A1 (en) * | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
EP1982990A1 (en) | 1998-03-19 | 2008-10-22 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
CA2363779A1 (en) | 1999-02-26 | 2000-08-31 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
US6270460B1 (en) * | 1999-06-24 | 2001-08-07 | Acuson Corporation | Apparatus and method to limit the life span of a diagnostic medical ultrasound probe |
EP1276849A4 (en) | 2000-04-12 | 2004-06-09 | Human Genome Sciences Inc | Albumin fusion proteins |
US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
WO2001096528A2 (en) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
US6849194B2 (en) | 2000-11-17 | 2005-02-01 | Pcbu Services, Inc. | Methods for preparing ethers, ether compositions, fluoroether fire extinguishing systems, mixtures and methods |
EP1683865A3 (en) | 2001-02-02 | 2006-10-25 | Eli Lilly & Company | Mammalian proteins and in particular CD200 |
JP2005503116A (en) | 2001-02-09 | 2005-02-03 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | Human G protein chemokine receptor (CCR5) HDGNR10 |
DE60236646D1 (en) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 antibodies |
DE10119522A1 (en) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Preparation and application of a suspension composition with an ultrasound contrast medium |
EP2277889B1 (en) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusion proteins of albumin and interferon beta |
AU2003235791A1 (en) | 2002-01-08 | 2003-07-24 | Chiron Corporation | Gene products differentially expressed in cancerous breast cells and their methods of use |
US7300743B2 (en) * | 2003-03-06 | 2007-11-27 | E. I. Du Pont De Nemours And Company | Radiation durable organic compounds with high transparency in the vacuum ultraviolet, and method for preparing |
EP1628992A4 (en) | 2003-05-13 | 2008-04-16 | Novartis Vaccines & Diagnostic | Methods of modulating metastasis and skeletal related events resulting from metastases |
US20050074406A1 (en) * | 2003-10-03 | 2005-04-07 | Scimed Life Systems, Inc. | Ultrasound coating for enhancing visualization of medical device in ultrasound images |
BRPI0507026A (en) | 2004-02-09 | 2007-04-17 | Human Genome Sciences Inc | albumin fusion proteins |
US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
CA2790675C (en) | 2005-07-19 | 2016-12-20 | Stemgen S.P.A. | Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps |
US7943134B2 (en) | 2005-08-31 | 2011-05-17 | Academia Sinica | Compositions and methods for identifying response targets and treating flavivirus infection responses |
KR20140077946A (en) | 2005-10-13 | 2014-06-24 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Methods and compositions for use in treatment of patients with autoantibody positive diseases |
JP5191392B2 (en) | 2005-11-07 | 2013-05-08 | ザ スクリプス リサーチ インスティチュート | Compositions and methods for modulating the specificity of tissue factor signaling |
US7572618B2 (en) | 2006-06-30 | 2009-08-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
EP2260102A1 (en) | 2008-03-25 | 2010-12-15 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by down-regulating frizzled-4 and/or frizzled-1 |
CA2723171C (en) * | 2008-05-02 | 2018-03-27 | Celsense, Inc. | Emulsion compositions and methods for nuclear magnetic resonance and other imaging |
GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
US20100160576A1 (en) * | 2008-11-21 | 2010-06-24 | University Of Tennessee Research Foundation | Perfluorinated poly(oxymethylene) compounds |
EP2241323A1 (en) | 2009-04-14 | 2010-10-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Tenascin-W and brain cancers |
EP2292266A1 (en) | 2009-08-27 | 2011-03-09 | Novartis Forschungsstiftung, Zweigniederlassung | Treating cancer by modulating copine III |
EP2480573A1 (en) | 2009-09-22 | 2012-08-01 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mex-3 |
WO2011045352A2 (en) | 2009-10-15 | 2011-04-21 | Novartis Forschungsstiftung | Spleen tyrosine kinase and brain cancers |
US20120213801A1 (en) | 2009-10-30 | 2012-08-23 | Ekaterina Gresko | Phosphorylated Twist1 and cancer |
EP2542578A1 (en) | 2010-03-05 | 2013-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Smoc1, tenascin-c and brain cancers |
WO2011131611A1 (en) | 2010-04-19 | 2011-10-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Modulating xrn1 |
US20130089538A1 (en) | 2010-06-10 | 2013-04-11 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute forBiomedical Researh | Treating cancer by modulating mammalian sterile 20-like kinase 3 |
US20130171159A1 (en) | 2010-09-10 | 2013-07-04 | Brian Arthur Hemmings | Phosphorylated twist1 and metastasis |
WO2012168259A1 (en) | 2011-06-06 | 2012-12-13 | Novartis Forschungsstiftung, Zweigniederlassung | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer |
EP2776022A1 (en) | 2011-11-08 | 2014-09-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
EP2776838A1 (en) | 2011-11-08 | 2014-09-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Early diagnostic of neurodegenerative diseases |
EP2800583A1 (en) | 2012-01-02 | 2014-11-12 | Novartis AG | Cdcp1 and breast cancer |
JP2013180956A (en) * | 2012-02-29 | 2013-09-12 | Sunstar Engineering Inc | Bactericidal agent composition |
WO2013144240A1 (en) | 2012-03-29 | 2013-10-03 | Friedrich Miescher Institute For Biomedical Research | Inhibition of interleukin- 8 and/or its receptor cxcrl in the treatment her2/her3 -overexpressing breast cancer |
WO2014001482A1 (en) | 2012-06-29 | 2014-01-03 | Novartis Forschungsstiftung, Zweigniererlassung, Friedrich Miescher Institute For Biomedical Research | Treating diseases by modulating a specific isoform of mkl1 |
EP2870242A1 (en) | 2012-07-05 | 2015-05-13 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
WO2014006115A1 (en) | 2012-07-06 | 2014-01-09 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction |
US20160178610A1 (en) | 2013-08-07 | 2016-06-23 | Friedrich Miescher Institute For Biomedical Research | New screening method for the treatment Friedreich's ataxia |
WO2015189816A1 (en) | 2014-06-13 | 2015-12-17 | Friedrich Miescher Institute For Biomedical Research | New treatment against influenza virus |
US10308935B2 (en) | 2014-06-23 | 2019-06-04 | Friedrich Miescher Institute For Biomedical Research | Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small RNAS |
US20170165261A1 (en) | 2014-07-01 | 2017-06-15 | Brian Arthur Hemmings | Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma |
WO2016046768A1 (en) | 2014-09-24 | 2016-03-31 | Friedrich Miescher Institute For Biomedical Research | Lats and breast cancer |
CN104353088A (en) * | 2014-09-30 | 2015-02-18 | 东南大学 | Preparation method of lipid bubbles |
US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
MX2017008721A (en) | 2014-12-31 | 2017-11-17 | Lantheus Medical Imaging Inc | Lipid-encapsulated gas microsphere compositions and related methods. |
US20180348224A1 (en) | 2015-10-28 | 2018-12-06 | Friedrich Miescher Institute For Biomedical Resear Ch | Tenascin-w and biliary tract cancers |
EP3176206A1 (en) * | 2015-12-01 | 2017-06-07 | Evonik Degussa GmbH | Method for the preparation of fine cell foams using a cell aging inhibitor |
KR20180133527A (en) | 2016-05-04 | 2018-12-14 | 랜티우스 메디컬 이메징, 인크. | Method and apparatus for producing ultrasound contrast agent |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US11225689B2 (en) | 2016-08-17 | 2022-01-18 | The Broad Institute, Inc. | Method for determination and identification of cell signatures and cell markers |
WO2018067991A1 (en) | 2016-10-07 | 2018-04-12 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
US11913075B2 (en) | 2017-04-01 | 2024-02-27 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
US11680296B2 (en) | 2017-10-16 | 2023-06-20 | Massachusetts Institute Of Technology | Mycobacterium tuberculosis host-pathogen interaction |
EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway |
US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
WO2019213660A2 (en) | 2018-05-04 | 2019-11-07 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses |
US20210371932A1 (en) | 2018-06-01 | 2021-12-02 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
WO2020077236A1 (en) | 2018-10-12 | 2020-04-16 | The Broad Institute, Inc. | Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues |
US20210379057A1 (en) | 2018-10-16 | 2021-12-09 | Massachusetts Institute Of Technology | Nutlin-3a for use in treating a mycobacterium tuberculosis infection |
US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
US20230053540A1 (en) | 2019-02-19 | 2023-02-23 | Massachusetts Institute Of Technology | Treatment of liver injury |
US20220154282A1 (en) | 2019-03-12 | 2022-05-19 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
US20220143148A1 (en) | 2019-03-14 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells |
US20220142948A1 (en) | 2019-03-18 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
US20220152148A1 (en) | 2019-03-18 | 2022-05-19 | The Broad Institute, Inc. | Modulation of type 2 immunity by targeting clec-2 signaling |
US20220226464A1 (en) | 2019-05-28 | 2022-07-21 | Massachusetts Institute Of Technology | Methods and compositions for modulating immune responses |
US20220243178A1 (en) | 2019-05-31 | 2022-08-04 | The Broad Institute, Inc. | Methods for treating metabolic disorders by targeting adcy5 |
WO2021030627A1 (en) | 2019-08-13 | 2021-02-18 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
US11865168B2 (en) | 2019-12-30 | 2024-01-09 | Massachusetts Institute Of Technology | Compositions and methods for treating bacterial infections |
WO2024016003A2 (en) | 2022-07-14 | 2024-01-18 | The Broad Institute, Inc. | Aav capsids that enable cns-wide gene delivery through interactions with the transferrin receptor |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052575A2 (en) * | 1980-11-17 | 1982-05-26 | Schering Aktiengesellschaft | Composition generating microbubbles |
WO1993005819A1 (en) * | 1991-09-17 | 1993-04-01 | Sonus Pharmaceuticals, Inc | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
WO1994009703A1 (en) * | 1992-11-02 | 1994-05-11 | Drexel University | Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same |
WO1994021301A1 (en) * | 1993-03-16 | 1994-09-29 | Holmes, Michael, John | Improvements in or relating to contrast agents |
WO1994028939A1 (en) * | 1993-06-04 | 1994-12-22 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
DE4406474A1 (en) * | 1994-02-23 | 1995-08-24 | Schering Ag | Gas-containing microparticles, agents containing them, their use in ultrasound diagnostics, and methods for producing the particles and agents |
WO1996009793A1 (en) * | 1994-09-28 | 1996-04-04 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
WO1996026746A1 (en) * | 1995-02-28 | 1996-09-06 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4657756A (en) * | 1980-11-17 | 1987-04-14 | Schering Aktiengesellschaft | Microbubble precursors and apparatus for their production and use |
DE3141641A1 (en) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION |
US4718433A (en) * | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
US4586511A (en) * | 1983-03-04 | 1986-05-06 | Children's Hospital Medical Center | Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance |
US5141738A (en) * | 1983-04-15 | 1992-08-25 | Schering Aktiengesellschaft | Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof |
DE3313947A1 (en) * | 1983-04-15 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS |
DE3324754A1 (en) * | 1983-07-06 | 1985-01-17 | Schering AG, 1000 Berlin und 4709 Bergkamen | ULTRASONIC CONTRASTING AGENTS AND THEIR PRODUCTION |
GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
US5186922A (en) * | 1985-03-15 | 1993-02-16 | See/Shell Biotechnology, Inc. | Use of biodegradable microspheres labeled with imaging energy constrast materials |
US4613326A (en) * | 1985-07-12 | 1986-09-23 | Becton, Dickinson And Company | Two-component medication syringe assembly |
DE3529195A1 (en) * | 1985-08-14 | 1987-02-26 | Max Planck Gesellschaft | CONTRAST AGENTS FOR ULTRASONIC EXAMINATIONS AND METHOD FOR THE PRODUCTION THEREOF |
US4684479A (en) * | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
DE3688613T2 (en) * | 1985-11-18 | 1994-01-13 | Access Pharma Inc | POLYCHELING SUBSTANCES FOR IMAGING AND SPECTRAL INCREASING (AND SPECTRAL SHIFT). |
US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
EP0231091B1 (en) * | 1986-01-24 | 1993-03-31 | Children's Hospital Medical Center | Stable emulsions of highly fluorinated organic compound |
US4925678A (en) * | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
US4781676A (en) * | 1987-02-20 | 1988-11-01 | Air Products And Chemicals, Inc. | Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells |
US5108759A (en) * | 1987-04-01 | 1992-04-28 | Ranney David F | Endothelial envelopment drug carriers |
DE3741201A1 (en) * | 1987-12-02 | 1989-06-15 | Schering Ag | ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT |
DE3741199A1 (en) * | 1987-12-02 | 1989-08-17 | Schering Ag | USE OF ULTRASONIC CONTRASTING AGENTS FOR ULTRASONIC LITHOTRIPSY |
US4844882A (en) * | 1987-12-29 | 1989-07-04 | Molecular Biosystems, Inc. | Concentrated stabilized microbubble-type ultrasonic imaging agent |
WO1989006978A1 (en) * | 1988-02-05 | 1989-08-10 | Schering Aktiengesellschaft Berlin Und Bergkamen | Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents |
US4898734A (en) * | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US6088613A (en) * | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5209720A (en) * | 1989-12-22 | 1993-05-11 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US5149319A (en) * | 1990-09-11 | 1992-09-22 | Unger Evan C | Methods for providing localized therapeutic heat to biological tissues and fluids |
US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5334381A (en) * | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5305757A (en) * | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
DE4004430A1 (en) * | 1990-02-09 | 1991-08-14 | Schering Ag | CONSTRUCTED POLYALDEHYDE CONSTITUENTS |
GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
US5556610A (en) * | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
IN172208B (en) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5205287A (en) * | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
GB9009423D0 (en) * | 1990-04-26 | 1990-06-20 | Williams Alun R | Assessment of vascular perfusion by the display of harmonic echoes from ultrasonically excited gas bubbles |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US5315997A (en) * | 1990-06-19 | 1994-05-31 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging using diamagnetic contrast |
JP2599492B2 (en) * | 1990-08-21 | 1997-04-09 | 第一製薬株式会社 | Manufacturing method of liposome preparation |
JP3247374B2 (en) * | 1990-10-05 | 2002-01-15 | ブラッコ インターナショナル ベスローテン フェンノートシャップ | A method for the production of stable suspensions of hollow gas-encapsulated microspheres suitable for ultrasound ecology |
DE4100470A1 (en) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echo contrast agent |
US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
EP0504881B2 (en) * | 1991-03-22 | 2000-11-08 | Katsuro Tachibana | Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same |
US5205290A (en) * | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
JP3319754B2 (en) * | 1991-06-03 | 2002-09-03 | ニユコメド・イメージング・アクシエセルカペト | Improvements in or on contrast agents |
ATE151993T1 (en) * | 1991-07-05 | 1997-05-15 | Nycomed Imaging As | IMPROVEMENTS TO CONTRAST AGENTS |
GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
WO1993003671A1 (en) * | 1991-08-13 | 1993-03-04 | Molecular Biosystem, Inc. | Method of mri imaging using diamagnetic contrast agents |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
MX9205298A (en) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA |
WO1993006869A1 (en) * | 1991-10-04 | 1993-04-15 | Mallinckrodt Medical, Inc. | Gaseous ultrasound contrast agents |
US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
US5196183A (en) * | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
DE4219723A1 (en) * | 1992-06-13 | 1993-12-16 | Schering Ag | Microparticles, processes for their production and their use in diagnostics |
AU4563093A (en) * | 1992-07-03 | 1994-01-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echographic contrast agent composition |
CA2144749A1 (en) * | 1992-09-16 | 1994-03-31 | Jo Klaveness | Improvements in or relating to contrast agents |
US5314644A (en) * | 1992-10-19 | 1994-05-24 | Virginia Polytechnic Institute And State University | Microbubble generator |
US5393527A (en) * | 1993-01-04 | 1995-02-28 | Becton, Dickinson And Company | Stabilized microspheres and methods of preparation |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
WO1994016739A1 (en) * | 1993-01-25 | 1994-08-04 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
DK0693924T4 (en) * | 1993-02-22 | 2008-08-04 | Abraxis Bioscience Inc | Process for (in vivo) delivery of biological materials and compositions suitable therefor |
US5333613A (en) * | 1993-03-23 | 1994-08-02 | Delineate | Microparticles as ultrasonic contrast media |
KR100295173B1 (en) * | 1993-12-15 | 2001-09-17 | 엔. 토모브 | Gas Mixtures Useful as Ultrasonic Contrast Media |
US5502094A (en) * | 1994-05-20 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use |
US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
GB9808599D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
GB9808582D0 (en) * | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to contrast agents |
-
1995
- 1995-06-07 US US08/479,621 patent/US5804162A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 DE DE69621015T patent/DE69621015T2/en not_active Expired - Fee Related
- 1996-06-05 CZ CZ973913A patent/CZ391397A3/en unknown
- 1996-06-05 AU AU60487/96A patent/AU712946B2/en not_active Ceased
- 1996-06-05 DK DK96918164T patent/DK0833669T3/en active
- 1996-06-05 DE DE69636486T patent/DE69636486T2/en not_active Expired - Fee Related
- 1996-06-05 EP EP01119824A patent/EP1174153B1/en not_active Expired - Lifetime
- 1996-06-05 PL PL96323868A patent/PL185883B1/en unknown
- 1996-06-05 AT AT01119824T patent/ATE337018T1/en not_active IP Right Cessation
- 1996-06-05 ES ES96918164T patent/ES2176462T3/en not_active Expired - Lifetime
- 1996-06-05 ES ES01119824T patent/ES2269262T3/en not_active Expired - Lifetime
- 1996-06-05 WO PCT/US1996/009068 patent/WO1996040281A2/en not_active Application Discontinuation
- 1996-06-05 HU HU9900848A patent/HUP9900848A3/en unknown
- 1996-06-05 KR KR1019970709075A patent/KR100401429B1/en not_active IP Right Cessation
- 1996-06-05 US US08/973,281 patent/US6193952B1/en not_active Expired - Fee Related
- 1996-06-05 AT AT96918164T patent/ATE216894T1/en not_active IP Right Cessation
- 1996-06-05 CA CA002222186A patent/CA2222186A1/en not_active Abandoned
- 1996-06-05 EP EP96918164A patent/EP0833669B1/en not_active Expired - Lifetime
- 1996-06-05 JP JP50147797A patent/JP4067116B2/en not_active Expired - Fee Related
- 1996-06-05 CN CN96195879A patent/CN1087954C/en not_active Expired - Fee Related
- 1996-06-05 IL IL12221796A patent/IL122217A/en not_active IP Right Cessation
- 1996-06-05 PT PT96918164T patent/PT833669E/en unknown
-
1997
- 1997-11-19 NO NO975317A patent/NO975317L/en not_active Application Discontinuation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052575A2 (en) * | 1980-11-17 | 1982-05-26 | Schering Aktiengesellschaft | Composition generating microbubbles |
WO1993005819A1 (en) * | 1991-09-17 | 1993-04-01 | Sonus Pharmaceuticals, Inc | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
WO1994009703A1 (en) * | 1992-11-02 | 1994-05-11 | Drexel University | Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same |
WO1994021301A1 (en) * | 1993-03-16 | 1994-09-29 | Holmes, Michael, John | Improvements in or relating to contrast agents |
WO1994028939A1 (en) * | 1993-06-04 | 1994-12-22 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
DE4406474A1 (en) * | 1994-02-23 | 1995-08-24 | Schering Ag | Gas-containing microparticles, agents containing them, their use in ultrasound diagnostics, and methods for producing the particles and agents |
WO1996009793A1 (en) * | 1994-09-28 | 1996-04-04 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
WO1996026746A1 (en) * | 1995-02-28 | 1996-09-06 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
Non-Patent Citations (1)
Title |
---|
KABALNOV, ALEXEY ET AL: "Phospholipids as Emulsion Stabilizers. 1. Interfacial Tensions", LANGMUIR (1995), 11(8), 2966-74 CODEN: LANGD5;ISSN: 0743-7463, 1995, XP002019542 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1996040281A3 (en) | Gas emulsions stabilized with fluorinated ethers having low ostwald coefficients | |
WO1992018165A3 (en) | Improved fluorocarbon contrast media for use with MRI and radiographic imaging | |
AU7221398A (en) | Method of demarcating tissue | |
AU5247390A (en) | Stable emulsion of perfluoropolyethers | |
CA2027516A1 (en) | Perfluorinated ether ternary system | |
EP0910219A3 (en) | Method for reducing processing power requirements of a video decoder | |
CA2119129A1 (en) | Gaseous Ultrasound Contrast Media and Method for Selecting Gases for Use as Ultrasound Contrast Media | |
EP1596604A3 (en) | Apparatus for coding/decoding and filtering method for the reduction of artifacts in reconstructed images | |
CA2273140A1 (en) | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media | |
IL112951A (en) | Optical gain medium having doped nanocrystals of semiconductors and also optical scatterers | |
EP2332579A3 (en) | Antibodies that bind human interleukin-18 and methods of making and using | |
EP0833517A3 (en) | Fixed or adaptive deinterleaved transform coding for image coding and intra coding of video | |
SE9800088D0 (en) | Long filter lossless region of interest coding | |
WO2005082009A3 (en) | Small field-of-view detector head ('spect') attenuation correction system | |
EP2110307A3 (en) | Mooring system | |
AU2001280429A1 (en) | Reduction of motion artifact in nmr images using spherical navigator signals | |
WO2001071536A8 (en) | System and method for multi-party constrained optimization | |
EP1143427A3 (en) | Optical recording method, optical recording apparatus, and optical recording medium | |
AU3559600A (en) | Application head for an apparatus used in cosmetic surgery and electromedicine | |
AU9730798A (en) | Epoxide hydrolase | |
EP0980910A3 (en) | Hydrofluoropolyether-based azeotropic or near azeotropic compositions | |
DE60319972D1 (en) | COMPOSITE PIEZOELECTRIC BODY | |
WO2002077712A3 (en) | Photoresist composition | |
EP0840522A3 (en) | Improvements in or relating to image display systems | |
Woods et al. | Motion compensated multiresolution transmission of HDTV |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 96195879.0 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA |
|
COP | Corrected version of pamphlet |
Free format text: PAGES 1/5-5/5,DRAWINGS,REPLACED BY NEW PAGES 1/8-8/8;DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2222186 Country of ref document: CA Ref document number: 2222186 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/1997/009564 Country of ref document: MX |
|
ENP | Entry into the national phase |
Ref document number: 1997 501477 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV1997-3913 Country of ref document: CZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1019970709075 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1996918164 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08973281 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1996918164 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: PV1997-3913 Country of ref document: CZ |
|
WWP | Wipo information: published in national office |
Ref document number: 1019970709075 Country of ref document: KR |
|
AK | Designated states |
Kind code of ref document: B1 Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: B1 Designated state(s): KE LS MW SD SZ UG AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
WWG | Wipo information: grant in national office |
Ref document number: 1996918164 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1019970709075 Country of ref document: KR |
|
WWR | Wipo information: refused in national office |
Ref document number: PV1997-3913 Country of ref document: CZ |