WO1996040282A3 - Nucleation and activation techniques for use in ultrasound imaging - Google Patents

Nucleation and activation techniques for use in ultrasound imaging Download PDF

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Publication number
WO1996040282A3
WO1996040282A3 PCT/US1996/009108 US9609108W WO9640282A3 WO 1996040282 A3 WO1996040282 A3 WO 1996040282A3 US 9609108 W US9609108 W US 9609108W WO 9640282 A3 WO9640282 A3 WO 9640282A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleation
ultrasound imaging
activation techniques
activation
liquid
Prior art date
Application number
PCT/US1996/009108
Other languages
French (fr)
Other versions
WO1996040282A2 (en
Inventor
Steven C Quay
Dean R Kessler
Ronald A Roy
Dilip Worah
Original Assignee
Sonus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sonus Pharma Inc filed Critical Sonus Pharma Inc
Priority to AU63277/96A priority Critical patent/AU6327796A/en
Priority to EP96922392A priority patent/EP0871499A1/en
Priority to JP9501508A priority patent/JPH11506960A/en
Publication of WO1996040282A2 publication Critical patent/WO1996040282A2/en
Publication of WO1996040282A3 publication Critical patent/WO1996040282A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media

Abstract

A method of activating an ultrasound contrast agent such that an increased number of microbubbles are produced and subsequent ultrasound images using the activated agent are enhanced. Hypobaric methods are disclosed which provide significant increases in bubble population per unit volume over unactivated solutions. The method is particularly useful for the activation of the dispersed phase in a gas or liquid in liquid emulsion.
PCT/US1996/009108 1995-06-07 1996-06-06 Nucleation and activation techniques for use in ultrasound imaging WO1996040282A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU63277/96A AU6327796A (en) 1995-06-07 1996-06-06 Nucleation and activation techniques for use in ultrasound i maging
EP96922392A EP0871499A1 (en) 1995-06-07 1996-06-06 Nucleation and activation techniques for use in ultrasound imaging
JP9501508A JPH11506960A (en) 1995-06-07 1996-06-06 Nucleation and activation methods for use in ultrasound imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47746295A 1995-06-07 1995-06-07
US08/477,462 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040282A2 WO1996040282A2 (en) 1996-12-19
WO1996040282A3 true WO1996040282A3 (en) 1997-04-24

Family

ID=23896009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009108 WO1996040282A2 (en) 1995-06-07 1996-06-06 Nucleation and activation techniques for use in ultrasound imaging

Country Status (5)

Country Link
US (1) US5897851A (en)
EP (1) EP0871499A1 (en)
JP (1) JPH11506960A (en)
AU (1) AU6327796A (en)
WO (1) WO1996040282A2 (en)

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US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
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EP0935415B1 (en) 1996-05-01 2006-11-22 Imarx Pharmaceutical Corp. In vitro methods for delivering nucleic acids into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
AU7702798A (en) 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
ES2243270T3 (en) * 1999-05-21 2005-12-01 Mallinckrodt Inc. RESUSPENSION DEVICE OF A CONTRAST AGENT.
GB9920392D0 (en) * 1999-08-27 1999-11-03 Nycomed Imaging As Improvemets in or relating to diagnostic imaging
WO2004069153A2 (en) * 2003-01-27 2004-08-19 Medrad, Inc. Apparatus, system and method for generating bubbles on demand
CN101291705A (en) * 2005-06-07 2008-10-22 皇家飞利浦电子股份有限公司 Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US9921125B2 (en) * 2014-03-27 2018-03-20 Nxp Usa, Inc. Leak detector using capacitance sensor
US9322797B1 (en) * 2014-04-30 2016-04-26 Helvetia Wireless Llc Systems and methods for detecting a liquid
CA2972423A1 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
TWI740937B (en) 2016-05-04 2021-10-01 美商藍瑟斯醫學影像公司 Methods and devices for preparation of ultrasound contrast agents
FR3052351B1 (en) * 2016-06-10 2021-11-26 Centre Hospitalier Regional Univ Damiens PROCESS FOR MEASURING HEART RATE BY ECHOGRAPHY
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

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Also Published As

Publication number Publication date
EP0871499A1 (en) 1998-10-21
AU6327796A (en) 1996-12-30
JPH11506960A (en) 1999-06-22
WO1996040282A2 (en) 1996-12-19
US5897851A (en) 1999-04-27

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