WO1998008462A2 - Daisy occluder and method for septal defect repair - Google Patents
Daisy occluder and method for septal defect repair Download PDFInfo
- Publication number
- WO1998008462A2 WO1998008462A2 PCT/US1997/014822 US9714822W WO9808462A2 WO 1998008462 A2 WO1998008462 A2 WO 1998008462A2 US 9714822 W US9714822 W US 9714822W WO 9808462 A2 WO9808462 A2 WO 9808462A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- arms
- septal defect
- frame
- defect occluder
- occluder
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00592—Elastic or resilient implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00597—Implements comprising a membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00606—Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
Definitions
- the present invention relates to an occluder structure and method for the repair of intracardiac and vascular septal defects, as well as other abnormal openings in tissue planes such as the abdominal wall.
- a septum which is a thin wall of muscle or tissue which divides two or more chambers of the heart or other anatomic spaces of the human body, sometimes is perforated by an abnormal aperture passing through the septum, described as a septal defect.
- septal defects occur between adjacent chambers of the heart or its associated major blood vessels, blood can leak from one chamber or artery to another imposing added strain on the heart which may lead to heart failure.
- An opening in the abdominal wall may allow bowel to pass through it, causing a hernia.
- Dr. William Rashkind developed an umbrella type occluder which relied upon hooks to attach the device on one side of the atrial septum. This device was difficult to position and the hooks were very difficult to disengage.
- U.S. Patent No. 4,917,089 to Sideris discloses an occluder which is positioned on the distal side of a defect and an occluder holder which is positioned on the proximal side. These elements are separately delivered to the site of the defect and then connected together by a button closure. The extensive manipulation required to connect and deploy this device increases the likelihood that the device will be improperly positioned or accidentally released into the bloodstream. Fagan et al.
- U.S. Patent No. 5,425,744 discloses a dual umbrella-type occluder which may be deployed as a single unitary unit, while U.S. Patent No. 5,451,235 to Lock et al.
- FIG. 1 shows a similar occlusion device wherein the dual umbrella units are interconnected to allow relative movement so as to provide improved seating of the device.
- Proper positioning and seating of an occluder has been a problem which was difficult to solve with previously known devices, and a need exists for a septal occluder which is self centering, self locating, and which effectively closes septal defects in a range of sizes and shapes.
- Another object of the present invention is to provide a novel and improved septal defect occluder including a wire frame formed of a single length of wire with only a single weld.
- the frame is preferably formed with triple front and rear petal loops extending in overlapping planes, though quadruple, quintuple or more loops could be used on both sides.
- Still another object of the present invention is to provide a novel and improved septal defect occluder formed with front and rear alternative petal loops extending in spaced, substantially parallel planes which are joined at the loop inner ends by loop joinder links which extend between alternate front and rear petals and the overlapping planes of the petal tips.
- the loop joinder links extend through the opening in the septum so that the deployed device will expand and adjust automatically to fit the size and shape of the opening.
- Yet another object of the present invention is to provide a novel and improved septal defect occluder having a frame with joined front and rear petal loops extending in spaced, substantially parallel planes with soft, stretchable sheets of polymer material extending over the front and rear sets of loops and which are held in place without stitching.
- the sheets of material are formed with pockets which receive the tips of the petal loops of the occluder frame.
- a further object of the present invention is to provide a novel and improved method and mandrel for forming a septal occluder frame from a single length of spring wire or shape memory material wherein the frame includes joined occluder petal loops extending in overlapping, substantially parallel planes.
- Yet a further object of the present invention is to provide a novel and improved delivery unit and method for delivering and locating a septal defect occluder.
- Another object of the present invention is to provide a novel and improved septal defect occluder having a frame formed from radially extending looped petals where all loops are resilient enough to move independently when the frame is expanded. The loops are joined by joinder links at the center of the frame with sufficient flexibility to expand to fit a defect in the septum as it enlarges over time.
- a still further object of the invention is to provide a novel and improved septal defect occluder having a frame formed from radially extending looped petals which are joined by joinder links at the center of the frame.
- a removable lasso looped about the joinder links aids in delivering and positioning the occluder and can be used to contract and retrieve an improperly positioned occluder.
- Figure 1 is a plan view of one side of the septal defect occluder of the present invention.
- Figure 2 is a sectional view of a fully deployed occluder of the present invention
- Figure 3 is a diagrammatic plan view of a deployed occluder of the present invention in a large defect
- Figure 4 is a diagrammatic plan view of a similar deployed occluder of the present invention in a small defect
- Figure 5 is a sectional view of the distal and proximal ends of a delivery catheter system for the septal defect occluder of the present invention
- Figure 6 is a sectional view of the pusher handle of the delivery unit of Figure 5;
- Figure 7 is a perspective view of a jig for forming the frame for the occluder of the present invention.
- Figure 8 is a plan view of one side of the jig of Figure 7;
- Figure 9 is a plan view of the opposite side of the jig of Figure 8.
- Figure 10 is a plan view of a second embodiment of a jig for forming the occluder of the present invention with the plates in a straight- line configuration;
- Figure 1 1 is a view in side elevation of two adjacent plates for the ig of Figure 10;
- Figure 12 is a plan view of a single plate for the jig of Figure 10;
- Figure 13 is a plan view of the jig of Figure 10 with the plates in a circular configuration; and Figure 14 is a diagrammatic plan view of an expanded occluder of the present invention showing the positioning lasso construction and a sectional view of a delivery unit.
- the daisy septal defect occluder of the present invention indicated generally at 10 includes a wire frame 12 preferably formed from a single length of wire.
- the frame 12 includes a front set of spaced, loop shaped petals 14 including petals 14a, 14b and 14c extending outwardly in a first plane and a rear set of loop shaped petals including petals or arms 16a, 16b and 16c extending outwardly in a second plane spaced from, and substantially parallel to, said first plane.
- each of the rear loop shaped petals is positioned between two of the front loop shaped petals and is connected at its two base points 18 to base points 20 of the two adjacent front loop shaped petals by loop joinder links 22.
- These loop joinder legs are arranged around the circumference of a circle which will expand or contract depending upon the size of the defect in a septum 23 through which the joinder links will extend when the occluder is in place.
- the wire frame 12 is formed of a length of resilient wire which may be a spring metal wire, but which preferably is formed of a shape memory material such as nitinol.
- a shape memory material such as nitinol.
- the frame rigidifies to an extent necessary to maintain is expanded shape but is flexible enough to expand or contract within a range to accommodate a range of septal opening sizes and shapes.
- the longest and smallest expansion points for one size of frame are illustrated by Figures 3 and 4, respectively.
- Frames can be formed to fit a number of size ranges.
- the tips 24 of the rear petals 16a, 16b and 16c are curved forwardly toward the front petals and the tips 26 of the front petals 14a, 14b and 14c are curved rearwardly toward the rear petals so that the planes of the alternating petal tips may overlap.
- the occluder 10 When the occluder 10 is positioned over a septal defect, these petal tips engage and corrugate the septum 23 to hold the occluder in place.
- the front petals 14a, 14b and 14c of the frame 12 support a polygonal membrane or sheet of material 28 while the rear petals 16a, 16b and 16c support a polygonal membrane or sheet of material 30.
- These sheets which are triangular when three petals 14 and 16 are used, form spaced closure units for a septal defect to span and close the proximal and distal sides of the defect, and are formed of a material having some elasticity such as sheets of elastic dacron.
- Each triangular sheet is similar in construction and is formed with a pocket 32 at each point of the triangle to receive the end tips of either the front or rear petals.
- the front petals support the front sheet 28 and the rear petals support the back sheet 30 without having the front and rear sheets stitched to the wire frame 12.
- one rear petal 16a is formed to be longer than the remaining front and rear petals, and the pocket 32 which retains this petal is provided with an opening at the apex thereof to permit the loop end 36 of this petal to be exposed. This loop end passes through the opening and provides a recess to receive a hook member for positioning the occluder 10.
- a single occluder 10 will effectively close septal defects within a range from a small defect opening 38 to a large defect opening 40.
- the petals extending in one plane define the points of a triangle, and the petals of both planes support two offset triangular sheets where the points at the triangles are offset by sixty degrees.
- Figures 5 and 6 disclose a simple delivery device for the occluder 10.
- the occluder is compressed within an open ended tubular portion 44 of a catheter delivery system 46 with the front petals 14 positioned toward the forward or distal open end of the tubular portion and the rear petals 16 pointing backward toward the proximal end.
- the loop end 36 of the petal 16a projects rearwardly for engagement with a hook 48 at the end of a delivery unit 50.
- the delivery unit includes an elongate wire 52 with the hook 48 formed at the distal end thereof and a handle 54 formed at the proximal end. The wire 52 extends through the catheter 46 to bring the hook 48 into engagement with the loop end 36.
- a sleeve 56 pivoted to the handle 54 is pivoted downwardly into engagement with the wire 52, to define a distance A between the sleeve and catheter equal to the distance A' required to deploy the front petals 14 from the open end of the catheter tube 44.
- a safety monofilament lasso tether may be used when the occluder device is deployed so that it can be retrieved in an emergency if the deployed device is improperly seated over the septal defect.
- the monofilament loop extends the entire length of the delivery system and is positioned around the central links between the front and rear petals. If the device is correctly seated, the monofilament lasso is simply withdrawn after releasing one end. The entire delivery system is then removed. If the device is improperly seated, the tip of the delivery catheter is advanced so that the lasso is tightened and the device can be forcibly pulled into the catheter or a larger sheath and removed entirely.
- a first mandrel or jig 58 for forming the wire frame 12 is illustrated in Figures 7, 8 and 9.
- This jig is formed of metal and is disc shaped in configuration with a top surface 60 and a bottom surface 62.
- the top surface of the jig is provided with three grooves 64 which extend radially outward at 120° angles from the circumference of a hole 66 in the center of the jig.
- the bottom surface 70 at the outermost extremity of each groove 64 curves downwardly at 72 toward the bottom surface 62 of the jig for the purpose of curving the tip areas 26 of the petals 14a, 14b and 14c.
- Pins 68 are mounted to project upwardly from the bottom surface of each groove 64 at the outermost extremity thereof, and these pins are equally spaced from the circle 66.
- the base points 20 of the front petals 14 are defined by the circular hole 66 at the innermost extremity of each of the two sidewalls of each groove 64.
- the hole 66 extends through the jig between the top and the bottom surfaces thereof.
- the bottom surface of the jig 58 is provided with three radially extending grooves 78 which extend outwardly at 120° angles from the circle 66.
- Each groove 78 is positioned midway between two grooves 64, and it will be noted that the width of the grooves 64 and 78 is such that the grooves converge at the central hole 66.
- the bottom wall 80 of each of the grooves 78 curves at 82 at the outermost extremity of the groove, and in this instance, the curve is toward the top surface 60.
- Pins 84 project upwardly from the bottom wall 80 of two of the grooves 78, and these pins are spaced from the circle 66 for a distance equal to that of the pins 74.
- a third pin 86 in the remaining groove 78 projects upwardly from the bottom wall 80 of that groove and is spaced from the circle 66 for a distance which is greater than that of the remaining pins 74 and 84.
- a single length of wire having a first end 88 is hooked around the pin 86 and is then fed up through a hole 66 and down groove 64a and around pin 68 and then back through hole 66 to pin 84b in groove 78b.
- This alternative winding action continues around the jig 58 until the wire passes through the hole 66 and around the pin 86 where it meets the first wire end 88 at 90 and both ends are held by a locking screw. After annealing the two ends are welded together.
- the wire frame 12 is formed from a single wire with a single weld, and the added length of the petal formed about the pin 86 provides the loop end 36 in this petal.
- the bottom surfaces 70 of the grooves 64 are spaced from the bottom surfaces 80 of the grooves 78 so that the wire petals formed in the grooves 64 extend outwardly in a plane which is substantially parallel to, but spaced from, a plane in which the wire petals formed in the grooves 78 extend.
- the jig 58 is placed in an oven once the wire is wound in place to anneal the wire and set the final expanded shape of the device. Then the finished frame 12 is removed from the jig and the single wire weld is completed.
- An alternative star jig 92 for forming the frame 12 is illustrated in
- the star jig includes six pivotally connected elongated metal plates 94, 96, 98, 100, 102 and 104.
- the plates 94, 98 and 102 provide petals which extend in a first plane 106 while the plates 96, 100 and 104 are used to form petals which extend in a second substantially parallel, spaced plane 108.
- Each plate includes a curved guide slot 1 10 in the base area thereof and a laterally projecting lug 1 12 adjacent to the guide slot which supports an upwardly projecting point pin 1 14.
- the pivot pin is positioned to extend through the lowermost end of the guide slot in the next adjacent plate, and the pivot pins for the plates 96-104 are fixed while the pivot pin 1 14a for the plate 94 is removable.
- At the lowermost extremity of each plate on the side opposite to the lug 112 is an outwardly projecting notch 115. This notch is aligned with a notch 1 15a in the lug.
- each plate, at the outer extremity 1 16 includes three outwardly projecting spaced pins 118 which are used to form the front petals 14 and rear petals 16 of the wire frame 12. It will be noted from Figure 1 1 , that the pins 118 on the plates 94, 98 and 102 are formed on the outermost surface of these plates opposite to the outermost surface of the plates 96, 100 and 104 which bears the pins 118. Thus the pins 1 18 on the plates 96, 100 and 104 extend in a direction opposite to that of the pins 118 on the plates 94, 98 and 102.
- the plates of the jig are positioned in side by side relationship as shown in Figure 10, and a first end 120 of the wire is locked under a screw 122 on the plate 94.
- the wire is then wound around two of the three pins 118 on the plate 94 and a fourth pin 124 projecting from the same surface of this plate and then through the notches 1 15 and 115a to the opposite surface of the plate 96.
- the wire is then wound around the pins 118 on the plate 96 and then back through the notches 1 15 and 115a to the pins on the opposite surface of the plate 98.
- the jig 92 bearing the wire is placed in an oven to anneal the deployed shape of the device when the wire is formed of nitinol or similar shape memory material when the transition temperature is reached.
- the wire frame 12 can be removed and trimmed around the weld 140.
- the petals 14 and 16 are inserted into the pockets 32 of the front and back sheets 28 and 30 and the front and back sheets are fused at their center or otherwise attached at 34 of the circularly arranged loop joined links 22.
- the loop shaped petals 14 and 16 of the frame 12 are each relatively movable when the frame is expanded so that stresses are not confined to specific areas of the frame.
- the loop joinder links 22 form a post for the frame at the center thereof, and within the range of expansion of the frame, control expansion in relation to the size of the septal defect which is occluded. In children, as the child and the defect grow in size, the occluder frame adjusts to insure that defect remains covered.
- the elongate monofilament tether 150 has two ends 152 and 154 which pass through the catheter delivery system 46. Beginning at end 152, the tether passes through a first opening 156 in the fused center of the front and rear membrane sheets 28 and 30 and then loops downwardly to reenter a first opening 159 in the front sheet 28 so as to lie in the space between the sheets 28 and 30 and around the loop joinder links 22 between all of the petals 14 and 16. The tether then passes out through a second opening 161 in the front sheet 28 and then loops upwardly through a second opening 158 in the fused center of the rear membrane sheet and back as end 154 through the catheter delivery system.
- a button 162 is pulled to remove the tether from the occluder out through the catheter delivery system. If the occluder is improperly seated over the defect, both ends 152 and 154 of the tether may be pulled back into the catheter delivery system by means of the button 162 causing the tether lasso to tighten around the loop joinder links 22 to cause the occluder to contract toward the center and permit the occluder to be drawn back into the tubular portion 44 of the delivery system.
- an improperly positioned occluder can easily be withdrawn and later a more appropriately sized occluder device can be inserted and repositioned properly.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002264151A CA2264151C (en) | 1996-08-28 | 1997-08-28 | Daisy occluder and method for septal defect repair |
AU41583/97A AU4158397A (en) | 1996-08-28 | 1997-08-28 | Daisy occluder and method for septal defect repair |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/697,832 | 1996-08-28 | ||
US08/697,832 US5741297A (en) | 1996-08-28 | 1996-08-28 | Daisy occluder and method for septal defect repair |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998008462A2 true WO1998008462A2 (en) | 1998-03-05 |
WO1998008462A3 WO1998008462A3 (en) | 1998-04-23 |
Family
ID=24802759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/014822 WO1998008462A2 (en) | 1996-08-28 | 1997-08-28 | Daisy occluder and method for septal defect repair |
Country Status (4)
Country | Link |
---|---|
US (1) | US5741297A (en) |
AU (1) | AU4158397A (en) |
CA (1) | CA2264151C (en) |
WO (1) | WO1998008462A2 (en) |
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WO2000012012A1 (en) * | 1998-08-28 | 2000-03-09 | Gore Enterprise Holdings, Inc. | Self-expanding defect closure device |
WO2000069365A3 (en) * | 1999-05-13 | 2001-03-08 | St Jude Medical Cardiovascular | Septal defect closure device |
EP1214911A1 (en) * | 1999-05-13 | 2002-06-19 | St. Jude Medical Cardiovascular Group, Inc. | Septal defect closure device |
US6712836B1 (en) | 1999-05-13 | 2004-03-30 | St. Jude Medical Atg, Inc. | Apparatus and methods for closing septal defects and occluding blood flow |
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US8114102B2 (en) | 2003-06-16 | 2012-02-14 | St. Jude Medical Atg, Inc. | Temporary hemostatic plug apparatus and method of use |
US8162974B2 (en) | 2006-02-02 | 2012-04-24 | Boston Scientific Scimed, Inc. | Occlusion apparatus, system, and method |
US8568431B2 (en) | 2004-03-03 | 2013-10-29 | W.L. Gore & Associates, Inc. | Delivery/recovery system for septal occluder |
US8758403B2 (en) | 2001-12-19 | 2014-06-24 | W.L. Gore & Associates, Inc. | PFO closure device with flexible thrombogenic joint and improved dislodgement resistance |
US8979941B2 (en) | 2006-08-09 | 2015-03-17 | Coherex Medical, Inc. | Devices for reducing the size of an internal tissue opening |
US9017373B2 (en) | 2002-12-09 | 2015-04-28 | W.L. Gore & Associates, Inc. | Septal closure devices |
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US9084603B2 (en) | 2005-12-22 | 2015-07-21 | W.L. Gore & Associates, Inc. | Catch members for occluder devices |
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US6656206B2 (en) | 1999-05-13 | 2003-12-02 | Cardia, Inc. | Occlusion device with non-thrombogenic properties |
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Also Published As
Publication number | Publication date |
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CA2264151A1 (en) | 1998-03-05 |
CA2264151C (en) | 2005-11-15 |
WO1998008462A3 (en) | 1998-04-23 |
AU4158397A (en) | 1998-03-19 |
US5741297A (en) | 1998-04-21 |
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