WO1998016257A3 - Stabilized microparticles and their use as ultrasound contrast agents - Google Patents

Stabilized microparticles and their use as ultrasound contrast agents Download PDF

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Publication number
WO1998016257A3
WO1998016257A3 PCT/US1997/019143 US9719143W WO9816257A3 WO 1998016257 A3 WO1998016257 A3 WO 1998016257A3 US 9719143 W US9719143 W US 9719143W WO 9816257 A3 WO9816257 A3 WO 9816257A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
target
exterior surface
useful
targeting molecules
Prior art date
Application number
PCT/US1997/019143
Other languages
French (fr)
Other versions
WO1998016257A2 (en
Inventor
Rolf Lohrmann
Brent Lee Golec
Original Assignee
Molecular Biosystems Inc
Rolf Lohrmann
Brent Lee Golec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Biosystems Inc, Rolf Lohrmann, Brent Lee Golec filed Critical Molecular Biosystems Inc
Priority to EP97911882A priority Critical patent/EP0932419A2/en
Priority to JP51866898A priority patent/JP2001506587A/en
Priority to CA002268763A priority patent/CA2268763A1/en
Publication of WO1998016257A2 publication Critical patent/WO1998016257A2/en
Publication of WO1998016257A3 publication Critical patent/WO1998016257A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

Microparticles useful for enhancing the ultrasound image of a tissue or organ consist of liquid and/or gas core material which is encapsulated by a biocompatible, tanned protein shell. These stabilized microparticles are useful as ultrasonic imaging agents, and are additionally useful in the further production of functionalized microparticles for in vivo imaging. In particular, targeting molecules such as antibodies or other ligands can be attached to the strengthened exterior surface of the stabilized microparticles to impart target-specificity to the microparticles. The targeting molecules may also provide hydrophilicity to the exterior surface, thus increasing the recirculation time of the microparticles. The targeting molecules may be attached directly to the exterior surface of the microparticles, or they may be attached via a bifunctional spacer arm, which may itself be hydrophilic. The target-specific microparticles are injected intravenously, allowed to accumulate at the target site, and used to enhance the ultrasound image of a target tissue or organ.
PCT/US1997/019143 1996-10-17 1997-10-17 Stabilized microparticles and their use as ultrasound contrast agents WO1998016257A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97911882A EP0932419A2 (en) 1996-10-17 1997-10-17 Stabilized microparticles and their use as ultrasound contrast agents
JP51866898A JP2001506587A (en) 1996-10-17 1997-10-17 Stable microparticles and their use as ultrasonic contrast agents
CA002268763A CA2268763A1 (en) 1996-10-17 1997-10-17 Stabilized microparticles and their use as ultrasound contrast agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73559496A 1996-10-17 1996-10-17
US08/735,594 1996-10-17

Publications (2)

Publication Number Publication Date
WO1998016257A2 WO1998016257A2 (en) 1998-04-23
WO1998016257A3 true WO1998016257A3 (en) 1998-08-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019143 WO1998016257A2 (en) 1996-10-17 1997-10-17 Stabilized microparticles and their use as ultrasound contrast agents

Country Status (5)

Country Link
US (2) US6083484A (en)
EP (1) EP0932419A2 (en)
JP (1) JP2001506587A (en)
CA (1) CA2268763A1 (en)
WO (1) WO1998016257A2 (en)

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FR2862536B1 (en) * 2003-11-21 2007-11-23 Flamel Tech Sa PHARMACEUTICAL FORMULATIONS FOR THE PROLONGED DELIVERY OF ACTIVE (S) PRINCIPLE (S) AND THEIR PARTICULARLY THERAPEUTIC APPLICATIONS
US8323620B2 (en) * 2004-10-22 2012-12-04 Hitachi Medical Corporation Ultrasound contrast agent
JP5037350B2 (en) * 2004-11-03 2012-09-26 アイリス モレキュラー ダイアグノスティクス， インコーポレイテッド Microbubbles for affinity separation
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EP1885335A1 (en) * 2005-04-27 2008-02-13 BAXTER INTERNATIONAL INC. (a Delaware corporation) Surface-modified microparticles and methods of forming and using the same
CN104815331A (en) 2005-05-09 2015-08-05 生物领域医疗公司 Compositions and methods using microspheres and non-ionic contrast agents
JP4652902B2 (en) * 2005-06-23 2011-03-16 株式会社日立ソリューションズ Stablely preserved carrier microparticles
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US20100074958A1 (en) * 2006-09-28 2010-03-25 Board Of Regents Of The University Of Texas System Methods and compositions for targeting fenestrated vasculature
AU2007319577A1 (en) * 2006-10-06 2008-05-22 Baxter Healthcare S.A. Microencapsules containing surface-modified microparticles and methods of forming and using the same
CN101765562B (en) * 2007-07-26 2013-05-29 国立大学法人东京工业大学 Process for production of surface-coated inorganic particles
AU2009215799B2 (en) * 2008-02-21 2013-08-22 Iris International Inc. Method for early determination of recurrence after therapy for prostate cancer
KR101367940B1 (en) * 2011-09-20 2014-02-28 한국과학기술원 Multi-Functional Nano Capsule and Method for Preparing Thereof
EP2964610A4 (en) * 2013-03-08 2016-11-23 Univ Southern California Usc Stevens Vinylsulfone-based 18f-labeling compositions and methods and uses thereof

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Also Published As

Publication number Publication date
US6193953B1 (en) 2001-02-27
JP2001506587A (en) 2001-05-22
WO1998016257A2 (en) 1998-04-23
US6083484A (en) 2000-07-04
CA2268763A1 (en) 1998-04-23
EP0932419A2 (en) 1999-08-04

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