WO1998018430A3 - P2y receptor antagonists - Google Patents
P2y receptor antagonists Download PDFInfo
- Publication number
- WO1998018430A3 WO1998018430A3 PCT/US1997/019922 US9719922W WO9818430A3 WO 1998018430 A3 WO1998018430 A3 WO 1998018430A3 US 9719922 W US9719922 W US 9719922W WO 9818430 A3 WO9818430 A3 WO 9818430A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor antagonists
- receptor
- antagonists
- utp
- atp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP52080798A JP2001504097A (en) | 1996-10-30 | 1997-10-23 | P2Y receptor antagonist |
AU55846/98A AU5584698A (en) | 1996-10-30 | 1997-10-23 | P2y receptor antagonists |
EP97952172A EP0929218A4 (en) | 1996-10-30 | 1997-10-23 | P2y receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2985596P | 1996-10-30 | 1996-10-30 | |
US60/029,855 | 1996-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998018430A2 WO1998018430A2 (en) | 1998-05-07 |
WO1998018430A3 true WO1998018430A3 (en) | 1998-06-18 |
Family
ID=21851254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/019922 WO1998018430A2 (en) | 1996-10-30 | 1997-10-23 | P2y receptor antagonists |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0929218A4 (en) |
JP (1) | JP2001504097A (en) |
AU (1) | AU5584698A (en) |
CA (1) | CA2241687A1 (en) |
WO (1) | WO1998018430A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1058686B1 (en) | 1998-02-25 | 2006-11-02 | Emory University | 2'-fluoronucleosides |
SE9802574D0 (en) * | 1998-07-17 | 1998-07-17 | Astra Pharma Prod | Novel compounds |
WO2001007054A1 (en) * | 1999-07-22 | 2001-02-01 | Supergen, Inc. | Methods for treating autoimmune diseases |
US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
WO2002062816A1 (en) * | 2001-02-07 | 2002-08-15 | Celltech R & D Limited | Non-natural nucleotides and dinucleotides |
WO2003039473A2 (en) * | 2001-11-06 | 2003-05-15 | Inspire Pharmaceuticals, Inc. | Method for treating or preventing inflammatory diseases |
KR20050097971A (en) * | 2003-02-03 | 2005-10-10 | 씨브이 쎄러퓨틱스, 인코포레이티드 | Partial and full agonists of a1 adenosine receptors |
US7550499B2 (en) * | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
WO2005113511A1 (en) * | 2004-05-12 | 2005-12-01 | Bristol-Myers Squibb Company | Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
WO2006078621A2 (en) | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
US7816382B2 (en) | 2005-06-27 | 2010-10-19 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition |
EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
KR20080027890A (en) * | 2005-06-27 | 2008-03-28 | 브리스톨-마이어스 스큅 컴퍼니 | N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
US7714002B2 (en) | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
EP2367837B1 (en) | 2006-11-17 | 2016-08-17 | MicroDose Therapeutx, Inc. | 1'-substituted ribose 5'-polyphosphate analogs and their use as modulators of p2y receptor activity |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
US5620676A (en) * | 1994-03-08 | 1997-04-15 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically active ATP analogs |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2122529A1 (en) * | 1971-05-06 | 1972-12-14 | Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen | Thiophosphate analogs of the nucleoside di and tnphosphate and processes for their preparation |
JPS4911896A (en) * | 1972-05-15 | 1974-02-01 | ||
DE2331223C2 (en) * | 1972-06-19 | 1984-11-22 | Kohjin Co., Ltd., Tokio / Tokyo | S-substituted-2-thioadenosines, their 5'-monophosphates, processes for their preparation and pharmaceuticals containing them |
US4266048A (en) * | 1977-10-11 | 1981-05-05 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) |
US4828979A (en) * | 1984-11-08 | 1989-05-09 | Life Technologies, Inc. | Nucleotide analogs for nucleic acid labeling and detection |
US4719295A (en) * | 1985-12-31 | 1988-01-12 | Warner-Lambert Company | Compound 2-iodo-2'-deoxyadenosine |
EP0508687B1 (en) * | 1991-04-06 | 1995-09-13 | Astra Pharmaceuticals Limited | ATP analogues |
JP3083156B2 (en) * | 1993-02-10 | 2000-09-04 | アストラ・フアーマシユウテイカルズ・リミテツド | N-alkyl-2-substituted ATP analogs |
WO1995010287A1 (en) * | 1993-10-15 | 1995-04-20 | Wisconsin Alumni Research Foundation | Substituted purine nucleoside analogs and method for treating endotoxin shock |
US5712258A (en) * | 1995-03-23 | 1998-01-27 | The Trustees Of The University Of Pennsylvania | Inotropic ADP and ATP analogues and their pharmaceutical compositions |
-
1997
- 1997-10-23 CA CA002241687A patent/CA2241687A1/en not_active Abandoned
- 1997-10-23 EP EP97952172A patent/EP0929218A4/en not_active Withdrawn
- 1997-10-23 WO PCT/US1997/019922 patent/WO1998018430A2/en not_active Application Discontinuation
- 1997-10-23 AU AU55846/98A patent/AU5584698A/en not_active Abandoned
- 1997-10-23 JP JP52080798A patent/JP2001504097A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
US5620676A (en) * | 1994-03-08 | 1997-04-15 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically active ATP analogs |
Non-Patent Citations (5)
Title |
---|
BR. J. PHARMACOL., 1996, Vol. 118, No. 8, BOYER J.L. et al., "Identification of Potent P2Y-Purinoceptor Agonists that are Derivatives of Adenosine 5'-Monophosphate", pages 1959-1964. * |
CHEMICAL ABSTRACTS, Abstract No. 126:43223, FAN J. et al., "DNA Sequencing with (.alpha.33-P)-Labelled ddNTP Terminators: A New Approach to DNA Sequencing with Thermo Sequenase DNA Polymerase"; & BIOTECHNIQUES, 1996, Vol. 21, No. 6, pages 1132-1137. * |
DRUG DESIGN AND DISCOVERY, 1995, Vol. 13, VANRHEE et al., "Modelling the P2Y Purinoceptor Using Rhodopsin as Template", pages 133-154. * |
PHARMACOLOGY TOXICOLOGY, 1995, Vol. 76, SIMON J. et al., "Characterization of P2Y Purinoceptor in Brain", pages 302-307. * |
See also references of EP0929218A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP0929218A2 (en) | 1999-07-21 |
EP0929218A4 (en) | 2001-05-16 |
CA2241687A1 (en) | 1998-05-07 |
JP2001504097A (en) | 2001-03-27 |
WO1998018430A2 (en) | 1998-05-07 |
AU5584698A (en) | 1998-05-22 |
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