WO1998021343A8 - Genes encoding telomerase proteins - Google Patents

Genes encoding telomerase proteins

Info

Publication number
WO1998021343A8
WO1998021343A8 PCT/US1997/021248 US9721248W WO9821343A8 WO 1998021343 A8 WO1998021343 A8 WO 1998021343A8 US 9721248 W US9721248 W US 9721248W WO 9821343 A8 WO9821343 A8 WO 9821343A8
Authority
WO
WIPO (PCT)
Prior art keywords
genes encoding
encoding telomerase
telomerase proteins
proteins
disclosed
Prior art date
Application number
PCT/US1997/021248
Other languages
French (fr)
Other versions
WO1998021343B1 (en
WO1998021343A1 (en
Inventor
Lea A Harrington
Murray O Robinson
Original Assignee
Amgen Inc
Amgen Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/751,189 external-priority patent/US5919656A/en
Application filed by Amgen Inc, Amgen Canada Inc filed Critical Amgen Inc
Priority to AU52644/98A priority Critical patent/AU5264498A/en
Priority to CA002271718A priority patent/CA2271718A1/en
Priority to JP52294198A priority patent/JP2001527385A/en
Priority to EP97947600A priority patent/EP0939823A1/en
Publication of WO1998021343A1 publication Critical patent/WO1998021343A1/en
Publication of WO1998021343B1 publication Critical patent/WO1998021343B1/en
Publication of WO1998021343A8 publication Critical patent/WO1998021343A8/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07049RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Abstract

Disclosed are nucleic acid molecules encoding polypeptides of the telomerase complex. Also disclosed are methods of preparing the nucleic acid molecules and polypeptides, and methods of using these molecules.
PCT/US1997/021248 1996-11-15 1997-11-13 Genes encoding telomerase proteins WO1998021343A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU52644/98A AU5264498A (en) 1996-11-15 1997-11-13 Genes encoding telomerase proteins
CA002271718A CA2271718A1 (en) 1996-11-15 1997-11-13 Genes encoding telomerase proteins
JP52294198A JP2001527385A (en) 1996-11-15 1997-11-13 Gene encoding telomerase protein
EP97947600A EP0939823A1 (en) 1996-11-15 1997-11-13 Genes encoding telomerase proteins

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/751,189 US5919656A (en) 1996-11-15 1996-11-15 Genes encoding telomerase protein 1
US08/751,189 1996-11-15
US87303997A 1997-06-11 1997-06-11
US08/873,039 1997-06-11
US08/951,733 US7390891B1 (en) 1996-11-15 1997-10-16 Polynucleotides encoding a telomerase component TP2
US08/951,733 1997-10-16

Publications (3)

Publication Number Publication Date
WO1998021343A1 WO1998021343A1 (en) 1998-05-22
WO1998021343B1 WO1998021343B1 (en) 1998-07-30
WO1998021343A8 true WO1998021343A8 (en) 2002-01-31

Family

ID=27419411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/021248 WO1998021343A1 (en) 1996-11-15 1997-11-13 Genes encoding telomerase proteins

Country Status (5)

Country Link
US (1) US7390891B1 (en)
EP (1) EP0939823A1 (en)
AU (1) AU5264498A (en)
CA (1) CA2271718A1 (en)
WO (1) WO1998021343A1 (en)

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CN102021153B (en) 1996-10-01 2016-05-25 杰龙公司 The mankind's telomerase catalytic subunit
US6777203B1 (en) 1997-11-19 2004-08-17 Geron Corporation Telomerase promoter driving expression of therapeutic gene sequences
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6475789B1 (en) 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6808880B2 (en) 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
US7622549B2 (en) * 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
WO1998059040A2 (en) * 1997-06-20 1998-12-30 Bayer Aktiengesellschaft Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
AU748442B2 (en) * 1997-07-01 2002-06-06 Cambia Vertebrate telomerase genes and proteins and uses thereof
EP1571215A3 (en) * 1997-07-01 2007-10-31 Cambia Biosystems LLC Vertebrate telomerase genes and proteins and uses thereof
US7378244B2 (en) 1997-10-01 2008-05-27 Geron Corporation Telomerase promoters sequences for screening telomerase modulators
WO1999027113A1 (en) * 1997-11-26 1999-06-03 Geron Corporation Mouse telomerase reverse transcriptase
AU3456099A (en) 1998-03-31 1999-10-18 Geron Corporation Methods and compositions for eliciting an immune response to a telomerase antigen
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US6337200B1 (en) 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US7030211B1 (en) * 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US6492171B2 (en) 2000-05-16 2002-12-10 Isis Pharmaceuticals, Inc. Antisense modulation of TERT expression
AUPR769701A0 (en) * 2001-09-14 2001-10-11 Li, He Telomerase inhibitory peptides and uses thereof
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
WO2008043760A1 (en) * 2006-10-12 2008-04-17 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
SI2536830T1 (en) 2010-02-16 2019-12-31 Ultimovacs As Polypeptides
EP3611184A1 (en) * 2012-09-19 2020-02-19 Gemvax & Kael Co., Ltd. Cell penetrating peptide, conjugate comprising the same, and composition comprising conjugate

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DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
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CN102021153B (en) * 1996-10-01 2016-05-25 杰龙公司 The mankind's telomerase catalytic subunit
US6475789B1 (en) * 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US6261836B1 (en) * 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6093809A (en) * 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants

Also Published As

Publication number Publication date
CA2271718A1 (en) 1998-05-22
WO1998021343A1 (en) 1998-05-22
AU5264498A (en) 1998-06-03
US7390891B1 (en) 2008-06-24
EP0939823A1 (en) 1999-09-08

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