WO1998024893A2 - TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM - Google Patents
TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM Download PDFInfo
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- WO1998024893A2 WO1998024893A2 PCT/US1997/023091 US9723091W WO9824893A2 WO 1998024893 A2 WO1998024893 A2 WO 1998024893A2 US 9723091 W US9723091 W US 9723091W WO 9824893 A2 WO9824893 A2 WO 9824893A2
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Definitions
- the present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci.
- animals in accordance with the invention possess human Ig loci that include plural variable (V H and VK) gene regions.
- V H and VK plural variable gene regions.
- the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
- Fully human antibodies are expected to minimize the immunogenic and allergic responses intrinsic to mouse or mouse-derivatized Mabs and thus to increase the efficacy and safety of the administered antibodies.
- the use of fully human antibodies can be expected to provide a substantial advantage in the treatment of chronic and recurring human diseases, such as inflammation, autoimmunity, and cancer, which require repeated antibody administrations.
- minilocus In an alternative approach, others, including GenPharm International, Inc., have utilized a "minilocus" approach. In the minilocus approach, an exogenous Ig locus is mimicked through the inclusion of pieces (individual genes) from the Ig locus. Thus, one or more V H genes, one or more D H genes, one or more J H genes, a mu constant region, and a second constant region (preferably a gamma constant region) are formed into a construct for insertion into an animal.
- This approach is described in U.S. Patent No. 5,545,807 to Surani et al. and U.S. Patent Nos. 5,545,806 and 5,625,825, both to Lonberg and Kay, and GenPharm International U.S. Patent Application Serial Nos.
- minilocus approach is the rapidity with which constructs including portions of the Ig locus can be generated and introduced into animals.
- a significant disadvantage of the minilocus approach is that, in theory, insufficient diversity is introduced through the inclusion of small numbers of V, D, and J genes. Indeed, the published work appears to support this concern. B-cell development and antibody production of animals produced through use of the minilocus approach appear stunted. Therefore, the present inventors have consistently urged introduction of large portions of the Ig locus in order to achieve greater diversity and in an effort to reconstitute the immune repertoire of the animals.
- transgenic animals containing more complete germline sequences and configuration of the human Ig locus. It would be additionally desirable to provide such locus against a knockout background of endogenous Ig.
- transgenic animals having a near complete human Ig locus, including both a human heavy chain locus and a human kappa light chain locus.
- the heavy chain locus includes greater than about 20%, more preferably greater than about 40%, more preferably greater than about 50%, and even more preferably greater than about 60% of the human heavy chain variable region.
- the locus includes greater than about 20%, more preferably greater than about 40%, more preferably greater than about 50%, and even more preferably greater than about 60% of the human kappa light chain variable region.
- Such percentages preferably refer to percentages of functional variable region genes.
- such animals include the entire D H region, the entire J H region, the human mu constant region, and can additionally be equipped with genes encoding other human constant regions for the generation of additional isotypes.
- Such isotypes can include genes encoding ⁇ ,, ⁇ 2 , ⁇ 3 , ⁇ , e, ⁇ , and other constant region encoding genes.
- Alternative constant regions can be included on the same transgene, i.e., downstream from the human mu constant region, or, alternatively, such other constant regions can be included on another chromosome.
- mice additionally do not produce functional endogenous immunoglobulins.
- This is accomplished in a preferred embodiment through the inactivation (or knocking out) of endogenous heavy and light chain loci.
- the mouse heavy chain J-region and mouse kappa light chain J-region and C ⁇ -region are inactivated through utilization of homologous recombination vectors that replace or delete the region.
- transgenic mice in accordance with the invention appear to possess an almost entirely reconstituted immune system repertoire. This is dramatically demonstrated when four separate mouse strains are compared: a first strain contains extensive human heavy chain variable regions and human kappa light chain variable regions and encodes only a mu isotype, a second strain contains extensive human heavy chain variable regions and human kappa light chain variable regions and encodes a mu and gamma-2 isotypes, a third strain contains significantly less human heavy and kappa light chain variable regions, and a fourth strain contains a double-inactivated mouse Ig locus.
- the first and second strains undergo similar, if not identical, B-cell development, whereas the third strain has a reduced development and maturation of B-cells, and the fourth strain contains no mature B-cells.
- production of human antibodies in preference to mouse antibodies is substantially elevated in mice having a knock-out background of endogenous Ig. That is to say that mice that contain a human Ig locus and a functionally inactivated endogenous Ig produce human antibodies at a rate of approximately 100 to 1000 fold as efficiently as mice that contain only a human Ig locus.
- a transgenic non-human mammal having a genome, the genome comprising modifications, the modifications comprising: an inactivated endogenous immunoglobulin (Ig) locus, such that the mammal would not display normal B-cell development; an inserted human heavy chain Ig locus in substantially germline configuration, the human heavy chain Ig locus comprising a human mu constant region and regulatory and switch sequences thereto, a plurality of human J H genes, a plurality of human D H genes, and a plurality of human V H genes; and an inserted human kappa light chain Ig locus in substantially germline configuration, the human kappa light chain Ig locus comprising a human kappa constant region, a plurality of J genes, and a plurality of V genes, wherein the number of V H and VK genes inserted are selected to substantially restore normal B-cell development in the mammal.
- Ig immunoglobulin
- the heavy chain Ig locus comprises a second constant region selected from the group consisting of human gamma- 1, human gamma-2, human gamma-3, human gamma-4, alpha, delta, and epsilon.
- the number of V H genes is greater than about 20.
- the number of VK genes is greater than about 15.
- the number of D H genes is greater than about 25, the number of J H genes is greater than about 4, the number of V H genes is greater than about 20, the number of JK genes is greater than about 4, and the number of VK genes is greater than about 15.
- the number of D H genes, the number of J H genes, the number of V H genes, the number of JK genes, and the number of VK genes are selected such that the Ig loci are capable of encoding greater than about 1 x 10 5 different functional antibody sequence combinations.
- B-cell function is reconstituted on average to greater than about 50% as compared to wild type.
- an improved transgenic non-human mammal having a genome thr.t comprises modifications, the modifications rendering the mammal capable of producing human immunoglobulin molecules but substantially incapable of producing functional endogenous immunoglobulin molecules, the improvement comprising: insertion into the genome of the mammal of sufficient human V H , D H , J H , VK, and JK genes such that the mammal is capable encoding greater than about 1 x 10 6 different functional human immunoglobulin sequence combinations.
- an improved transgenic non-human mammal having a genome that comprises modifications, the modifications rendering the mammal capable of producing human immunoglobulin molecules but substantially incapable of producing functional endogenous immunoglobulin molecules, which modifications, with respect to the mammal's incapacity to produce functional endogenous immunoglobulin molecules would not allow the mammal to display normal B-cell development, the improvement comprising: insertion into the genome of the mammal of sufficient human V H , D H , J H , VK, and JK genes such that the mammal is capable of encoding greater than about 1 x 10 6 different functional human immunoglobulin sequence combinations and sufficient V H and VK genes to substantially restore normal B-cell development in the mammal.
- B-cell function is reconstituted on average to greater than about 50% as compared to wild type.
- a transgenic non-human mammal having a genome, the genome comprising modifications, the modifications comprising: an inactivated endogenous heavy chain immunoglobulin (Ig) locus; an inactivated endogenous kappa light chain Ig locus; an inserted human heavy chain Ig locus, the human heavy chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yH2; and an inserted human kappa light chain Ig locus, the human kappa light chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yK2.
- Ig immunoglobulin
- a transgenic non- human mammal having a genome, the genome comprising modifications, the modifications comprising: an inactivated endogenous heavy chain immunoglubulin (Ig) locus; an inserted human heavy chain Ig locus, the human heavy chain Ig locus comprising a nucleotide sequence substantially corresponding to the nuc ,o otide sequence of yH2, and an inserted human kappa light chain Ig locus, the human kappa light chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yK2.
- Ig immunoglubulin
- a transgenic non- human mammal having a genome, the genome comprising modifications, the modifications comprising an inactivated endogenous heavy chain immunoglubulin (Ig) locus; an inactivated endogenous kappa light chain Ig locus; an inserted human heavy chain Ig locus, the human heavy chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yH2 without the presence of a human gamma-2 constant region; and an inserted human kappa light chain Ig locus, the human kappa light chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yK2
- Ig immunoglubulin
- transgenic non-human mammal having a genome, the genome comprising modifications, the modifications comprising an inactivated endogenous heavy chain immunoglubulin (Ig) locus, an inserted human heavy chain Ig locus, the human heavy chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yH2 without the presence of a human gamma-2 constant region, and an inserted human kappa light chain Ig locus, the human kappa light chain Ig locus comprising a nucleotide sequence substantially corresponding to the nucleotide sequence of yK2
- Ig immunoglubulin
- a method for the production of human antibodies comprising inoculating any of the mammals of the first through fifth aspects of the invention discussed above with an antigen, collecting and immortalizing lymphocytic cells to obtain an immortal cell population secreting human antibodies that specifically bind to the antigen with an affinity of greater than 10 9 M "1 , and isolating the antibodies from the immortal cell populations.
- the antigen is D -8 In another preferred embodiment, the antigen is EGFR. In another preferred embodiment, the antigen is TNF- ⁇
- an antibody produced by the method of the sixth aspect of the invention including antibodies to IL-8, EGFR, and TNF- ⁇ .
- an improved method for the production of transgenic mice having a genome, the genome comprising modifications, the modifications comprising insertion of a plurality of human variable regions, the improvement comprising: insertion of the human variable regions from a yeast artificial chromosome.
- transgenic mice and transgenic offspring therefrom produced through use of the improvement of the eighth aspect of the present invention.
- a transgenic mammal comprising a genome, the genome comprising modifications, the modifications comprising an inserted human heavy chain immunoglobulin transgene, the improvement comprising: the transgene comprising selected sets of human variable region genes that enable human-like junctional diversity and human-like complementarity determining region 3 (CDR3) lengths.
- the human-like junctional diversity comprises average N-addition lengths of 7.7 bases.
- the human-like CDR3 lengths comprise between about 2 through about 25 residues with an average of about 14 residues.
- FIG. 1 is a schematic representation of the reconstructed human heavy chain and human kappa light chain loci YACs introduced into preferred mice in accordance with the invention.
- YACs spanning the human heavy chain (1H, 2H, 3H, and 4H) and the human kappa light chain proximal (IK, 2K, and 3K) loci were cloned from human -YAC libraries.
- the locations of the different YACs with respect to the human Ig loci (adopted from Cook and Tomlinson, 1995, and Cox et al., 1994), their sizes, and non-Ig sequences are indicated (not shown to scale).
- the YACs were recombined into yeast in a two-step procedure (see Materials and Methods) to reconstruct the human heavy and kappa light chain YACs.
- yH2 the human heavy chain containing YAC, was further retrofitted with a human ⁇ 2 gene sequence.
- yK2 was the human kappa light chain containing YAC.
- V H segments are classified as genes with open reading frame •, pseudogenes D, and unsequenced genes O.
- V ⁇ segments are classified as genes with open reading frames •, and pseudogenes D.
- the V genes that we hav found to be utilized by the XenoMouse II are marked (*).
- the V H gene region contained on yH2 is marked by arrows.
- Figure 2 is a series of Southern Blot analyses and characterizations of the human heavy chain YAC, yH2, integrated in ES cells and in XenoMouse strains.
- Figure 2a is a series of Southern Blot analyses of EcoRI (a, c) and BamHI (b, d, e) digested DNA (2 ⁇ g) prepared from the CGM1 immortalized B-lymphoblast cell line derived from the Washington University YAC library source (Brownstein et al., 1989), yH2 YAC (0.5 ⁇ g YAC added to 2 ⁇ g of 3B1 DNA), unmodified E14TG.3B1 (3B1), and yH2-contain ⁇ ng ES cell lines: L10, J9.2, L18, L17, and J17.
- FIG. 2b is a series of Southern Blot analyses of EcoRI (a-b) and BamHI (c-d) digested DNA (10 ⁇ g) that was prepared from the tails of wildtype (WT, 129xB57BL/6J), XM2A-1, and XM2A-2 (2 individual offspring) mice or from the parental yH2-containing ES cell lines L10 (slightly underloaded relative to other samples), J9.2, and yK2-containing ES cell line J23.1.
- the probes used were human V H 1 (a), V H 4 (b), human ⁇ -2 (c), and mouse 3'-enhancer (d, the 5kb band represents the endogenous mouse 3'-enhancer fragment). Fragment sizes of molecular weight markers (in kb) are indicated.
- Figure 3 is a series of Southern Blot analyses characterizing the human kappa light chain YAC, yK2, integrated in ES cells and in XenoMouse 2A Strains
- Figure 2a is a series of Southern Blot analyses of EcoRI (a, c, d) and BamHI (b, e ) digested DNA (2 ⁇ g) prepared from CGM1 cell line (Brownstein et al., 1989, supra), yK2 YAC (0.5 ⁇ g YAC DNA added to 2 ⁇ g of 3B1 DNA), unmodified E14TG.3B1 (3B1), and yK2-containing ES cell lines: J23.1 and J23.7.
- Figure 2b is a series of Southern Blot analyses of EcoRI-digested DNA (2 ⁇ g) that was prepared from the tails of wildtype (WT, 129xB6), XM2A-1, and XM2A-2 (2 individual offspring) mice or from the parental yH2-containing ES cell lines L10 (slightly underloaded relative to other samples), J9.2, and yK2-containing ES cell line J23.1.
- the probes that were used were human V K I (a), V K IV (b), V K VI (c) and 3'-enhancer (d). Fragment sizes of molecular weight markers (in kb) are indicated.
- Figure 4 shows B-cell reconstitution and surface expression of human ⁇ , ⁇ , and K chains on XenoMouse-derived B-cells and shows flow cytometry analysis of peripheral blood (Fig. 4a) and spleen (Fig. 4b) lymphocytes from wildtype mice (WT), double inactivated mice (DI), and XenoMouse strains 2A-1 and 2A-2 (XM2A-1, XM2A-2).
- WT wildtype mice
- DI double inactivated mice
- XM2A-1, XM2A-2 Four-color flow cytometry analysis was carried out using antibodies to the B-cell-specific marker B220 in combination with anti-human ⁇ , ⁇ , K, or mouse ⁇ , ⁇ , K, or ⁇ . The percentage of positively-stained cells is shown in each quadrant.
- Figure 5 shows that XenoMouse-derived human antibodies block the binding of their specific antigens to cells.
- Figure 5a shows the inhibition of labeled [I 125 ] LL-8 binding to human neutrophils by the mouse anti-human IL-8 antibody (R&D Systems) (D) and the fully human Mabs Dl.1 ( ⁇ ), K2.2 (•), K4.2 (A), and K4.3 (T). The background binding of labeled [I 125 ]LL-8 in the absence of antibody was 2657 cpm.
- Figure 5b shows the inhibition of labeled [I I25 ]EGF to its receptors on A431 cells by mouse anti-human EGFR antibodies 225 and 528 (D, v, respectively; Calbiochem) and the fully human antibodies El.
- Figure 6 shows repertoire and somatic hypermutation in XenoMouse-derived fully human Mabs.
- the D and J genes of each antibody are indicated.
- the amino acid substitutions from the germline sequences are indicated in bold letters
- Figure 7 is a schematic diagram of the human heavy chain genome and the human kappa light chain genome
- Figure 8 is another schematic diagram showing the construction of the yH2 (human heavy chain) YAC
- Figure 9 is another schematic diagram showing the construction of the yK2 (human kappa light chain) YAC
- Figure 10 is another schematic diagram showing the construction of the yK2 (human kappa light chain) YAC
- Figure 11 shows a series of Southern Blot analyses demonstrating integration intact of the yH2 (human heavy chain) YAC into ES cells and into the mouse genome Detailed discussion is provided in connection with Figure 2
- Figure 12 shows a series of Southern Blot analyses demonstrating integration intact of the yK2 (human kappa light chain) YAC into ES cells and into the mouse genome Detailed discussion is provided in connection with Figure 3
- Figure 13 shows B-cell reconstitution and surface expression of human ⁇ , ⁇ , and K chains and mouse ⁇ chains on XenoMouse-derived B-cells and shows flow cytometry analysis of peripheral blood Further details are provided in connection with Figure 4
- Figure 14 shows production levels of human antibodies by XenoMouse II strains in comparison to mu ⁇ ne antibody production by wild type mice
- Figure 15 is a repertoire analysis of human heavy chain transcripts expressed in XenoMouse II strains
- Figure 16 is a repertoire analysis of human kappa light chain transcripts expressed in XenoMouse II strains
- Figure 17 is another depiction of the diverse utilization of human V H and VK genes that have been observed as utilized in XenoMouse II strains
- Figure 18 shows the titers of human antibody production in XenoMouse II strains
- Figure 19 is a depiction of gene utilization of anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 20 shows heavy chain amino acid sequences of anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 21 shows kappa light chain amino acid sequences of anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 22 shows blockage of IL-8 binding to human neutrophils by human anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 23 shows inhibition of CD1 lb expression on human neutrophils by human anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 24 shows inhibition of IL-8 induced calcium influx by human anti-EL-8 antibodies derived from XenoMouse II strains
- Figure 25 shows inhibition of IL-8 RB/293 chemotaxsis by human anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 26 is a schematic diagram of a rabbit model of human IL-8 induced skin inflammation.
- Figure 27 shows the inhibition of human IL-8 induced skin inflammation in the rabbit model of Figure 26 with human anti-IL-8 antibodies derived from XenoMouse II strains
- Figure 28 shows inhibition of angiogenesis of endothelial cells on a rat corneal pocket model by human anti-IL-8 antibodies derived from XenoMouse II strains.
- Figure 29 is a depiction of gene utilization of human anti-EGFR antibodies derived from XenoMouse II strains
- Figure 30 shows heavy chain amino acid sequences of human anti-EGFR antibodies derived from XenoMouse II strains
- Figure 31 shows blockage EGF binding to A431 cells by human anti-EGFR antibodies derived from XenoMouse II strains
- Figure 32 shows inhibition of EGF binding to SW948 cells by human anti-EGFR antibodies derived from XenoMouse II strains
- Figure 33 shows that human anti-EGFR antibodies derived from XenoMouse II strains inhibit growth of SW948 cells in vitro
- Figure 34 shows inhibition of TNF- ⁇ binding to U937 cells through use of human anti-TNF- ⁇ antibodies derived from XenoMouse II strains.
- Figure 35 shows kappa light chain amino acid sequences of human anti-EGFR antibodies derived from XenoMouse II strains.
- the present invention thus provides the first demonstration of reconstruction of the large and complex human Ig loci on YACs and the successful introduction of megabase-sized YACs into mice to functionally replace the corresponding mouse loci.
- mice The following mouse strains are described and/or utilized herein:
- Double Inactivated (DI) Strain The DI strain of mice are mice that do not produce functional endogenous, mouse, Ig. In preferred embodiments, the DI mice possess an inactivated mouse J H region and an inactivated mouse CK region. The construction of this strain is discussed extensively elsewhere. For example, the techniques utilized for generation of the DI strains are described in detail in U.S. Patent Application Serial Nos. 07/466,008, filed January 12, 1990, 07/610,515, filed November 8, 1990, 07/919,297, filed July 24, 1992, 08/031,801, filed March 15, 1993, 08/112,848, filed August 27, 1993, 08/234,145, filed April 28, 1994, 08/724,752, filed October 2, 1996.
- XenoMouse I Strain The design, construction, and analysis of the XenoMouse I strain was discussed in detail in Green et al., Nature Genetics, 7: 13-21 (1994). Such mice pre . ⁇ ced IgM ⁇ antibodies against a DI background. The mice showed improved B-cell function when compared to the DI strain of mice which have little to no B-cell development. While XenoMouse I strains of mice were capable of mounting a sizeable immune response to antigenic challenge, there appeared to be inefficient in their production of B-cells and possessed a limited response to different antigens which apparently was related to their limited V-gene repertoire.
- the L6 strain is a mouse producing IgM ⁇ antibodies against a DI background of endogenous mouse Ig.
- L6 mice contain an inserted human heavy chain and an inserted human kappa light chain.
- the L6 strain is generated through breeding of a mouse containing a heavy chain insert against a double inactivated background (L6H) and a mouse having a kappa light chain insert against a double inactivated background (L6L).
- the heavy chain insert comprises an intact approximately 970 kb human DNA insert from a YAC containing approximately 66 V H segments, starting at V H 6-1 and ending at V H 3-65, and including the major D gene clusters (approximately 32), J H genes (6), the intronic enhancer (Em), C ⁇ , and through about 25 kb past C ⁇ , in germline configuration.
- the light chain insert comprises an intact approximately 800 kb human DNA insert from a YAC which contains approximately 32 V ⁇ genes starting at V K . B3 and ending at V ⁇ o,,,,.
- the 800 kb insert contains a deletion of approximately 100 kb starting at V K . Lp . 13 and ending at V K . Lp . 5 .
- L6H and L6L mice have been shown to access the full spectrum of the variable genes incorporated into their genome. It is expected that the L6 mice will similarly access the full spectrum of variable genes in their genome. Furthermore, L6 mice will exhibit predominant expression of human kappa light chain, a large population of mature B-cells, and normal levels of IgM K human antibodies. Such mice will mount a vigorous human antibody response to multiple immunogens, ultimately yielding antigen-specific fully human Mabs with subnanomolar affinities.
- mice represent our second generation XenoMouseTM strains equipped with germline configuration megabase-sized human Ig loci, against a DI background, such th, the mice do not produce functional endogenous Ig.
- the mice are equivalent in construction to the L6 strain, but additionally include the human ⁇ 2 gene with its entire switch and regulatory sequences and the mouse 3' enhancer in cis.
- mice contain an approximately 1020 kb heavy and an approximately 800 kb kappa light chain loci, reconstructed on YACs, which include the majority of the human variable region genes, including heavy chain genes (approximately 66 V_) and kappa light chain genes (approximately 32 V ⁇ ), human heavy constant region genes ( ⁇ , ⁇ , and ⁇ ) and kappa constant region genes (C ⁇ ), and all of the major identified regulatory elements. These mice have been shown to access the full spectrum of the variable genes incorporated into their genome. Furthermore, they exhibit efficient class switching and somatic hypermutation, predominant expression of human kappa light chain, a large population of mature B- cells, and normal levels of IgM K and IgG K human antibodies.
- mice mount a vigorous human antibody response to multiple immunogens, including human JX-8, human EGF receptor (EGFR), and human tumor necrosis factor- ⁇ (TNF- ⁇ ), ultimately yielding antigen-specific fully human Mabs with subnanomolar affinities.
- human JX-8 human EGF receptor
- EGFR human EGF receptor
- TNF- ⁇ tumor necrosis factor- ⁇
- the XenoMouse II strain appears to undergo mature B-cell development and mount powerful adult-human-like immune responses to antigenic challenge.
- the L6 strain as predicted from the data in connection with L6L and L6H mice, also appear to undergo mature B-cell development and mount powerful adult-human-like immune responses to antigenic challenge.
- DI mice are compared to XenoMouse I strains and DI and XenoMouse I strains are compared to L6 and XenoMouse II strains, a markedly different B-cell development profile is observed.
- variable region sequences introduced into the animals are essential to the induction B-cell maturation and development and the generation of an adult-human-like immune response.
- the strains provide a valuable tool for studying the nature of human antibodies in the normal immune response, as well as the abnormal response characteristic of autoimmune disease and other disorders.
- the human heavy chain genome includes approximately 95 functional genes which encode variable regions of the human heavy chain of immunoglobulin molecules.
- the human light chain genome includes approximately 40 genes on its proximal end which encode variable regions of the human kappa light chain of immunoglobulin molecules.
- transgenic mice having a substantial portion of the human Ig locus, preferably including both a human heavy chain locus and a human kappa light chain locus.
- greater than 10% of the human V H and V ⁇ genes are utilized. More preferably, greater than about 20%, 30%, 40%, 50%, 60%, or even 70% or greater of V H and V ⁇ genes are utilized.
- constructs including 32 genes on the proximal region of the V ⁇ light chain genome are utilized and 66 genes on the V H portion of the genome are utilized.
- genes may be included either sequentially, i.e., in the order found in the human genome, or out of sequence, i.e., in an order other than that found in the human genome, or a combination thereof.
- an entirely sequential portion of either the V H or V ⁇ genome can be utilized, or various V genes in either the V H or V ⁇ genome can be skipped while maintaining an overall sequential arrangement, or V genes within either the V H or V ⁇ genome can be reordered, and the like.
- the entire inserted locus is provided in substantially germline configuration as found in humans. In any case, it is expected and the results described herein demonstrate that the inclusion of a diverse array of genes from the V H and V ⁇ genome leads to enhanced antibody specificity and ultimately to enhanced antibody affinities.
- mice include the entire D H region, the entire J H region, the human mu constant region, and can additionally be equipped with other human constant regions for the coding and generation of additional isotypes of antibodies.
- Such isotypes can include genes encoding ⁇ ,, ⁇ 2 , ⁇ 3 , ⁇ 4 , ⁇ , e, and ⁇ and other constant region encoding genes with appropriate switch and regulatory sequences.
- switch and regulatory sequences can be appropriately utilized in connection with any particular constant region selection.
- the following Table indicates the diversity of antibody combinations that are possible in humans, based strictly on random V-D-J joining and combination with kappa light chains, without consideration of N-addition or somatic mutation events. Based on these considerations, there are greater than 3.8 million possible antibody combinations in humans, of any particular isotype.
- mice in accordance with the invention such as the L6 and the XenoMouse II strains, offer substantial antibody diversity.
- mice are designed to have the capability of producing greater than 1 X 10 6 different heavy chain V-D-J combinations and kappa light chain V-J combinations, without accounting for N-additions or somatic mutation events.
- V-genes i.e., large and diverse numbers of V-genes
- qualitative selection of V-genes i.e., selection of particular V-genes
- Qualitative diversity refers to diversity in V-D-J rearrangements wherein junctional diversity and/or somatic mutation events are introduced.
- certain enzymes RAG-1, RAG- 2, and possibly others
- Terminal deoxynucleotidyl transferase (Tdt) activity is upregulated which is responsible for N-terminal additions of nucleotides between the V-D and D-Jgene segments. Similar enzymes and others (SCLD and other DNA repair enzymes) are responsible for the deletion that occurs at the junctions of these coding segments With respect to junctional diversity, both N- addition events and formation of the complementarity determining region 3 (CDR2, are included within such term As will be appreciated, CDR3 is located across the D region and includes the V-D and D-J junctional events Thus, N-additions and deletions during both D-J rearrangement and V-D rearrangement are responsible for CDR3 diversity
- V-D-J gene sequences show N-addition lengths that are comparable to expected adult-human N-addition lengths
- amino acid sequences across the open reading frame (ORF) corresponding to CDR3 sequences show CDR3 lengths that are comparable to expected adult-human CDR3 lengths.
- mice in accordance with the present invention possess enhanced affinities.
- Such data includes comparisons between mice in accordance with the invention and the XenoMouse I strains, as well as consideration of the published results of GenPharm International and the MRC.
- mice In connection with the XenoMouse I strains, as mentioned above, such mice possessed inefficient B- cell production and a limited response to different antigens. Such result appeared related in part to the limited V-gene repertoire. Similarly, results reported by GenPharm International and the MRC indicate a limited response to diverse antigens.
- association rates results in association rates (ka in M ⁇ S " ') of greater than about 0.50 X 10 "6 , preferably greater than 2.00 X 10 "6 , and more preferably greater than about 4.00 X 10 "6 ; dissociation rates (kd in S "1 ) of greater than about 1.00 X 10 " , preferably greater than about 2.00 X 10 "4 , and more preferably greater than about 4.00 X 10 "4 ; and dissociation constant (in M) of greater than about 1.00 X 10 "10 , preferably greater than about 2.00 X 10 "10 , and more preferably greater than about 4.00 X 10 "10 .
- mice additionally do not produce functional endogenous immunoglobulins.
- This is accomplished in a preferred embodiment through the inactivation (or knocking out) of endogenous heavy and light chain loci.
- the mouse heavy chain J-region and mouse kappa light chain J-region and C ⁇ -region are inactivated through utilization of homologous recombination vectors that replace or delete the region.
- B-cell development is reviewed in Klaus B Lymphocytes (LRL Press ( 1990)) and Chapters 1 -3 of Immunoglobulin Genes (Academic Press Ltd. (1989)), the disclosures of which are hereby incorporated by reference.
- blood cell development including B- and T-cell lymphocytes, originate from a common pluripotent stem cell.
- the lymphocytes then, evolve from a common lymphoid progenitor cell.
- B-cell initiation shifts from the liver to the bone marrow where it remains throughout the life of the mammal.
- the first generally recognizable cell is a pro-pre-B-cell which is found in the bone marrow.
- a pro-pre-B-cell which is found in the bone marrow.
- Such a cell has begun heavy chain V-D-J rearrangement, but does not yet make protein.
- the cell then evolves into a large, rapidly dividing, pre-B-cell I which is a cytoplasmically ⁇ * cell.
- This pre-B-cell I stops dividing, shrinks, and undergoes light chain V-J rearrangement becoming a pre-B-cell II which expresses surface IgM, which leave the marrow as immature B-cells.
- B-cell differentiation and development can be monitored and/or tracked through the use of surface markers.
- the B220 antigen is expressed in relative abundance on mature B-cells in comparison to pre-B-cells I or II.
- cells that are B220" and surface IgM ⁇ ( ⁇ + ) can be utilized to determine the presence of mature B-cells
- cells can be screened for surface IgD expression ( ⁇ + )
- Another antigen, heat stable antigen is expressed by pre-B-cells II as they transition to the periphery (i e., as they become ⁇ ⁇ and/or ⁇ + , ⁇ * )
- B-cell markers such as those mentioned above, development and differentiation of B-cells can be monitored and assessed.
- DI mice mice that do not undergo heavy chain V-D-J rearrangement or light chain V-J rearrangement
- B-cells never move from the bone marrow to pe ⁇ pheral tissues, including the spleen
- both B-cell development and antibody production are completely arrested
- mice having a knock-out background of endogenous Ig that is to say that mice that contain a human Ig locus and a functionally inactivated endogenous heavy chain Ig locus produce human antibodies at a rate of approximately 100 to 1000 fold as efficiently as mice that only contain a human Ig locus and are not inactivated for the endogenous locus.
- mice undergo efficient and effective isotype switching from the human transgene encoded mu isotype to the transgene encoded gamma-2 isotype.
- XenoMouse II strains that contain and encode the human gamma-4 constant region.
- mice in accordance with the invention can additionally be equipped with other human constant regions for the generation of additional isotypes.
- Such isotypes can include genes encoding ⁇ ,, ⁇ 2 , ⁇ 3 , ⁇ 4 , ⁇ , e, ⁇ , and other constant region encoding genes.
- Alternative constant regions can be included on the same transgene, i.e., downstream from the human mu constant region, or, alternatively, such other constant regions can be included on another chromosome. It will be appreciated that where such other constant regions are included on the same chromosome as the chromosome including the human mu constant region encoding transgene, cis-switching to the other isotype or isotypes can be accomplished.
- trans-switching to the other isotype or isotypes can be accomplished.
- Such arrangement allows tremendous flexibility in the design and construction of mice for the generation of antibodies to a wide array of antigens.
- B-cells can be screened for secretion of "chime ⁇ c" antibodies
- the L6 mice in addition to producing fully human IgM antibodies, produce antibodies having fully human heavy chain V, D, J regions coupled to mouse constant regions, such as a va ⁇ ety of gammas (1 e , mouse IgGl, 2, 3, 4) and the like
- mouse constant regions such as a va ⁇ ety of gammas (1 e , mouse IgGl, 2, 3, 4) and the like
- human constant regions can be included on the antibodies through in vitro isotype switching techniques well known in the art
- fragments (l e , F(ab) and F(ab') 2 fragments) of such antibodies can be prepared which contain little or no mouse constant regions
- the most c ⁇ tical factor to antibody production is specificity to a desired antigen or epitope on an "itigen Class of the antibody, thereafter, becomes important accord'ng to the therapeutic need In other words, will the therapeutic index of an
- Mate ⁇ als and Methods were utilized in connection with the generation and characterization of mice in accordance with the present invention Such Mate ⁇ als and Methods are meant to be illustrative and are not limiting to the present invention
- YAC targeting and recombination Standard methods for yeast growth, mating, sporulation, and phenotype testing were employed (Sherman et al, 1986) Targeting of YACs and YAC vector arms with yeast and mammalian selectable markers, to facilitate the screening of YAC recombinants in yeast of YAC integration into cells, was achieved by lithium acetate transformation (Scheistl and Geitz (1989) After every targeting or recombination step the modified YAC(s) was analyzed by pulsed field gel eletrophoresis an ⁇ ⁇ standard Southern Blots to determine the integ ⁇ ty of all sequ e nces YAC targeting vectors were used for the mterconversion of cent ⁇ c and acent ⁇ c arms to reo ⁇ ent 17H and to retrofit its 5' arm with LEU2 and URA3 genes and its 3' arm with the HIS3 gene See Fig 1 a and Mendez et al, 1993 The 4H cent ⁇ c arm was retro
- the 800 kb YAC contains a deletion of approximately 100 kb starting at V K . Lp . 13 and ending at V K.Lp.5 . However, the YAC is in germline configuration from V K . Lp . 13 to 100 kb past V ⁇ . ⁇ ,.
- the YAC also contains J ⁇ , the intronic and 3' enhancers, the constant C ⁇ , and Kde.
- YAC introduction into ES cells and mice YAC-containing yeast spheroplasts were fused with E14.TG3Bl ES cells as described (Jakobovits et al., 1993a; Green et al., 1994). HAT-resistant colonies were expanded for analysis.
- YAC integrity was evaluated by Southern Blot analysis using protocols and probes described in Berman et al., (1988) and Mendez et al., (1994) and hybridization conditions as described in Gemmil et al., (1991). Chimeric mice were generated by microinjection of ES cells into C57BL/6 blastocysts. YAC-containing offspring were identified by PCR analysis of tail DNA as described (Green et al., 1994).
- YAC integrity was evaluated by Southern Blot analysis using probes and conditions previously described, except that the blot probed with human V H 3 was washed at 50°C.
- Peripheral blood and spleen lymphocytes obtained from 8-10 week old XenoMice and control mice were purified on Lympholyte M (Accurate) and treated with purified anti-mouse CD32/CD16 Fc receptor (Pharmingen, 0124 ID) to block non-specific binding to Fc receptors, stained with antibodies and analyzed on a FACStar PLUS (Becton Dickinson, CELLQuest software).
- APC allophy
- XenoMice (8 to 10 weeks old) were immunized intraperitoneally with 25 ⁇ g of recombinant human IL-8 or with 5 ⁇ g TNF- ⁇ (Biosource International) emulsified in complete Freund's adjuvant for the primary immunization and in incomplete Freund's adjuvant for the additional immunizations carried out at two week intervals.
- TNF- ⁇ Biosource International
- XenoMice were immunized intraperitoneally with 2xl0 7 A431 (ATCC CRL-7907) cells resuspended in phosphate buffered saline (PBS). This dose was repeated three times.
- mice received a final injection of antigen or cells in PBS Spleen and lymph node lymphocytes from immunized mice were fused with the non-secretory myeloma NSO-bcl2 line (Ray and Diamond, 1994), and were subjected to HAT selection as previously described (Galfre and Milstein, 1981).
- ELISA assay ELISA for determination of antigen-specific antibodies in mouse serum and in hybridoma supernatants were carried out as described (Coligan et al., 1994) using recombinant human EL-8 and TNF- ⁇ and affinity-purified EGFR from A431 cells (Sigma, E-3641) to capture the antibodies.
- the concentration of human and mouse immunoglobulins were determined using the following capture antibodies' rabbit anti-human IgG (Southern Biotechnology, 6145-01), goat anti-human Ig ⁇ (Vector Laboratories, AI-3060), mouse anti-human IgM (CGI/ ATCC, HB-57), for human ⁇ , K, and ⁇ Ig, respectively, and goat anti-mouse IgG (Caltag, M 30100), goat anti-mouse Ig ⁇ (Southern Biotechnology, 1050-01), goat anti-mouse IgM (Southern Biotechnology, 1020-01), and goat anti-mouse ⁇ (Southern Biotechnology, 1060-01) to capture mouse ⁇ , K, ⁇ , and ⁇ Ig, respectively.
- the detection antibodies used in ELISA experiments were goat anti-mouse IgG-HRP (Caltag, M-30107), goat anti-mouse Ig ⁇ -HRP (Caltag, M 33007), mouse anti-human IgG2-HRP (Southern
- Affinity measurement by radioimmunoassay 125 I-labeled human LL-8 (1.5 x 10' 11 M or 3 x 10 " " M) was incubated with purified anti-JL-8 human antibodies at varying concentrations (5 x 10' 13 M to 4 x 10 "9 M) in 200 ⁇ l of PBS with 0.5% BSA. After 15 hrs. incubation at room temperature, 20 ⁇ l of Protein A Sepharose CL-4B in PBS (1/1, v/v) was added to precipitate the antibody-antigen complex. After 2 hrs.
- the antibody- I25 I-LL-8 complex bound to Protein A Sepharose was separated from free 125 I-IL-8 by filtration using 96-well filtration plates (Millipore, Cat. No. MADVN65), collected into scintillation vials and counted. The concentration of bound and free antibodies was calculated and the binding affinity of the antibodies to the specific antigen was obtained using Scatchart analysis (2).
- Receptor binding assays The IL-8 receptor binding assay was carried out with human neutrophils prepared either from freshly drawn blood or from buffy coats as described (Lusti- Marasimhan et al., 1995). Varying concentrations of antibodies were incubated with 0.23 nM [ 125 I]IL-8 (Amersham, IM-249) for 30 min at 4 t in 96-well Multiscreen filter plates (Millipore, MADV N6550) pretreated with PBS binding buffer containing 0.1% bovine serum albumin and 0.02% NaN 3 at 25°C for 2 hours. 4 X 10 5 neutrophils were added to each well, and the plates were incubated for 90 min at 4°C.
- Binding assays for TNF receptor were performed in a similar manner as the LL-8 assays described above. However, the human monocyte line U937 was utilized instead of the neutrophil line used in connection with the LL-8 assays. Antibodies were preincubated with 0.25 nM [ 125 ]TNF (Amersham, IM-206). 6 x 10 5 U937 cells were placed in each well.
- the EGF receptor binding assay was carried out with A431 cells (0.4 x 10 6 cells per well) which were incubated with varying concentrations of antibodies in PBS binding buffer for 30 minutes at 4°C. 0.1 nM [ I25 I]EGF (Amersham, LM-196) was added to each well, and the plates were incubated for 90 min at 4°C. The plates were washed five times, air-dried and counted in a scintillation counter. Anti-EGFR mouse antibodies 225 and 528 (Calbiochem) were used as controls.
- PCR products were cloned into pCRII using a TA cloning kit (Invitrogen) and both strands were sequenced using Prism dye-terminator sequencing kits and an ABI 377 sequencing machine. Sequences of human Mabs-derived heavy and kappa chain transcripts were obtained by direct sequencing of PCR products generated from poly(A') RNA using the primers described above. All sequences were analyzed by alignments to the "V BASE sequence directory" (Tomlinson et al., MRC Centre for Protein Engineering, Cambridge, UK) using Mac Vector and Geneworks software programs.
- V BASE sequence directory Tomlinson et al., MRC Centre for Protein Engineering, Cambridge, UK
- Antibody Fab fragments were produced by using immobilized papain (Pierce). The Fab fragments were purified with a two step chromatographic scheme: HiTrap (Bio-Rad) Protein A column to capture Fc fragments and any undigested antibody, followed by elution of the Fab fragments retained in the flow-through on strong cation exchange column (PerSeptive Biosystems), with a linear salt gradient to 0.5 M NaCl.
- Fab fragments were characterized by SDS-PAGE and MALDI-TOF MS under reducing and non-reducing conditions, demonstrating the expected -50 kD unreduced fragment and ⁇ 25 kDa reduced doublet. This result demonstrates the intact light chain and the cleaved heavy chain. MS uMer reducing conditions permitted the unambiguous identification of both the light and cleaved heavy chains since the light chain mass can be precisely determined by reducing the whole undigested antibody.
- the strategy that we utilized to reconstruct the human heavy chain and human kappa light chain variable regions was to, first, screen human- YAC libraries for YACs that spanned the large (megabase-sized) human Ig loci and, second, to recombine YACs spanning such regions into single YACs containing the desired loci predominantly in germline configuration.
- stepwise, YAC recombination scheme exploited the high frequency of meiotic-induced homologous recombination in yeast and the ability to select the desired recombinants by the yeast markers present on the vector arms of the recombined YACs (See Figure 1, and Green et al., supra., see also Silverman et al., 1990 and denDunnen et al., 1992).
- YACs 1H, 2H, 3H, and 4H were used for reconstruction of the locus (See Figure 1A).
- YAC 1H Pulsed Field Gel Electrophoresis (PFGE) and Southern blot analysis confirmed the YACs to be in intact, germline configuration, with the exception of 150 kb at the 3' end of YAC 2H which contained certain non-IgH sequences (See Figure 1; Matsuda et al., 1990).
- YAC 1H the YAC that was previously introduced into our first generation XenoMouseTM (Green et al., supra., Mendez et al., 1995), is comprised of the human C 5 , C ⁇ , J H , and D H regions and the first 5 V H genes in germline configuration.
- the other three YACs cover the majority of the V H region, from V H 2-5 to V H 3-65, thus contnbutmg approximately an additional 61 different V H genes Pnor to recombination, YAC 4H 'as retrofitted with an HPRT selectable marker
- the four YACs (1H, 2H, 3H, and 4H) were recombmed in yeast by a stepwise recombination strategy (See Figure 1A)
- Such recombination strategy generated a 980 kb recombinant YAC (See Figure 1)
- Analysis of the YAC by PFGE and Southern blot analysis confirmed the presence of the human heavy chain locus from the C ⁇ region to 20 kb 5' of the V H 3-65 gene in germline configuration No apparent deletions or rearrangements were observed
- the YAC acent ⁇ c arm was targeted with a vector bea ⁇ ng the complete human ⁇ 2 constant region, mouse 3' enhancer, and the neomycin resistance gene, to yield the final 1020 kb heavy chain YAC, yH2 YAC yH2 contained the majonty of the human va ⁇ able region I e , 66 out of the 82 V H genes, complete D H (32 genes), and J H (6 genes) regions and three different constant regions (C ⁇ , C ⁇ , and C ⁇ ) with their corresponding regulatory sequences (See Figure 1A) This was the heavy chain construct utilized for the production of our XenoMouse II strains
- YACs were identified that spanned the human kappa loci
- the YACs were designated IK, 2K and 3K YAC IK, which had a length of approximately 180 kb, had previously been introduced into our first generation XenoMouseTM
- Such YAC contained the kappa deleting element, (Kde), the kappa 3' and intronic enhancers, C ⁇ , J ⁇ , and the three V ⁇ genes on the B cluster (Green et al , 1994, Mendez et al , 1995)
- YAC 2K (approximately 480 kb), and 3K (approximately 380 kb) together encompass most of the kappa chain proximal va ⁇ able region on chromosome 2p
- a deletion of approximately 100 kb spans the L13-L5 region (Fig IB, Huber et al ,
- the YACs desc ⁇ bed herein, yH2 and yK2 represent the first megabase-sized reconstructed human Ig loci to contain the majonty of the human antibody repertoire, predominantly in germline configuration This accomplishment further confirmed homologous recombination in yeast as a powerful approach for successful reconstruction of large, complex, and unstable loci
- the selection of stable YAC recombinants contaimng large portions of the Ig loci in yeast provided us with the human Ig fragments required to equip the mice with the human antibody repertoire, constant regions, and regulatory elements needed to reproduce human antibody response in mice
- Example 3 Introduction ofvH2 and yK2 YACs into ES cells
- YACs mouse embryonic stem (ES) cells
- ES mouse embryonic stem
- YACs yH2 and yK2 were introduced into ES cells via fusion of YAC-containing yeast spheroplasts with HPRT-deficient E14 TG3B1 mouse ES cells as previously desc ⁇ bed (Jakobovits et al , 1993a, Green et al , 1994) HPRT-positive ES cell clones were selected at a frequency of 1 clone/ 15-20x10 6 fused cells and were analyzed for YAC integ ⁇ ty by Southern and
- V H 3, V H 4, V H 5, and V H 6 (data shown for 5 clones in Fig 2A) CHEF analysis further confirmed that these clones, which represent 20% of all clones analyzed, contain the entire intact yH2 YAC with no apparent deletions or rearrangements (data not shown)
- ES cell clones de ⁇ ved from the fusion of yK2-conta ⁇ n ⁇ ng yeast were similarly analyzed for YAC lnteg ⁇ ty, using probes specific for the human Kde, kappa 3' and intronic enhancers, C ⁇ , ⁇ and all of the different V ⁇ families V K I, V K II, V K III, V K IV, V K VI
- yH2- or yK2 -transgenic mice were bred with double-inactivated (DI) mouse strains
- DI mouse strains are homozygous for gene targeted-mactivated mouse heavy and kappa chain loci and thus are deficient in antibody production (Jakobovits et al , 1993b, Green et al , 1994)
- Two of the yH2- transgenic mouse strains L10 and J9 2, and one of the yK2 -transgenic mouse strains, J23 1 were bred with DI mice to generate mice bearing YACs on an homozygous inactivated mouse heavy and kappa chain background (yH2,DI, and yK2,DI)
- Each of the yH2,DI transgenic strains were bred with the yK2,DI transgenic strain to generate two XenoMouse II strains, 2A-1 (L10 23 1,DI) and 2A-2 (J
- Example 5 B-ce n development and human antibody production by XenoMouse II mice
- XenoMouse II strains we studied their B-cell development and their production of human antibodies Reconstitution of B-cell development and antibody production in XenoMouse II strains by yH2 and yK2 YACs was evaluated by flow cytometry and ELISA
- DI mice which completely lack mature B-cells
- XenoMouse II manifested essentially normal B-cell development with the mature B-cell population in the blood totaling over 50% of the level seen in wild type mice (Fig 4 A)
- All B-cells were shown to express human IgM and high levels of B220 (human IgM t B220 lu ), with 60% of this population also expressing human IgD Similar results were obtained from analysis of XenoMouse spleen and lymph nodes (not shown) These results correlate well with the characte ⁇ stics of mature B-cells in wild
- the L6 strain of mice were generated identically to the process desc ⁇ bed above in connection with the generation of the XenoMouse II strains However, owing to a deletion event du ⁇ ng the generation of the L6 ES cell line, the ES cell line, and, subsequently, the L6 mouse evolved without a portion of the sequence distal to C ⁇ , thus, eliminating the C ⁇ constant region and its regulatory sequences Following completion of breeding, the L6 mice will contain the entire yK2 construct and the entire yH2 construct, except for the missing C ⁇ constant region
- Example 8 A diverse human antibody repertoire in XenoMouse II
- Tables III and IV repertoire analyses of human heavy and kappa light chain transcripts expressed in XenoMouse II strains are presented Human ⁇ , ⁇ , and K specific mRNAs were amplified by PCR, cloned and analyzed by sequencing as described in Materials and Methods
- Table III shows a senes of nucleotide sequences of 12 unique human heavy chain clones, divided into V H , D, J H and N segments, as identified by homology with published germline sequences (Materials and Methods) Each D segment assignment is based on at least 8 bases of homology
- Table IV shows a senes of nucleotide sequences of V-J junctions of 8 independent human K clones The sequences are divided into V p J content and N segments and identified based on homology to published V ⁇ and l ⁇ sequences In each of the Tables N-additions and deletions (indicated as _ were determined by their lack of sequence homology to V, D, or J sequences
- antigens were prepared to human IL-8 and human EGFR
- the rationale for the selection of IL-8 and EGFR is as follows
- LL-8 is a member of the C-X-C chemokine family IL-8 acts as the primary chemoattractant for neutrophils implicated in many diseases, including ARDS, rheumatoid arthritis, inflammatory bowel disease, glomerulonephritis, psoriasis, alcoholic hepatitis, reperfusion injury, to name a few Moreover, LL-8 is a potent angiogenic factor for endothelial cells. In Figures 22-28, we demonstrate that human anti-LL-8 ant" odies derived from XenoMouse U strains are effective in a inhibiting LL-8's actions in a number of pathways.
- Figure 22 shows blockage of LL-8 binding to human neutrophils by human anti-IL-8.
- Figure 23 shows inhibition of CDl lb expression on human neutrophils by human anti-LL-8.
- Figure 24 shows inhibition of LL-8 induced calcium influx by human anti-IL-8 antibodies.
- Figure 25 shows inhibition of LL-8 RB/293 chemotaxsis by human anti-LL-8 antibodies.
- Figure 26 is a schematic diagram of a rabbit model of human LL-8 induced skin inflammation.
- Figure 27 shows the inhibition of human LL-8 induced skin inflammation in the rabbit model of Figure 26 with human anti-IL-8 antibodies.
- Figure 28 shows inhibition of angiogenesis of endothelial cells on a rat corneal pocket model by human anti-LL-8 antibodies.
- EGFR is viewed as an anti-cancer target.
- EGFR is overexpressed, up to 100 fold, on a variety of cancer cells.
- Ligand (EGF and TNF) mediated growth stimulation plays a critical role in the initiation and progression of certain tumors.
- EGFR antibodies inhibit ligand binding and lead to the arrest of tumor cell growth, and, in conjunction with chemotherapeutic agents, induces apoptosis.
- a combination of EGFR Mabs resulted in tumor eradication in murine xenogeneic tumor models.
- Imclone has conducted Phase I clinical utilizing a chimeric Mab (C225) that proved to be safe.
- Figures 31-33 we demonstrate data related to our human anti-EGFR antibodies.
- Figure 30 shows heavy chain amino acid sequences of human anti-EGFR antibodies derived from XenoMouse II strains.
- Figure 31 shows blockage EGF binding to A431 cells by human anti-EGFR antibodies.
- Figure 32 shows inhibition of EGF binding to SW948 cells by human anti-EGFR antibodies.
- Figure 33 shows that human anti-EGFR antibodies derived from XenoMouse II strains inhibit growth of SW948 cells in vitro.
- XenoMouse II could be harnessed to generate human antibodies to multiple antigens, in particular, human antigens of significant clinical interest.
- Affinity measurements were performed by solid phase measurements of both whole antibody and Fab fragments using surface plasmon resonance in BIAcore and in solution by radioimmunoassay
- the described Xenomouse-derived hybridomas produced antibodies at concentrations in the range of 2-19 ⁇ g/ml in static culture conditions. Characterization of the purified antibodies on protein gels under non-reducing conditions revealed the expected apparent molecular weight of 150 kD for the IgG 2 ⁇ antibody. Under reducing conditions the expected apparent molecular weights of 50 kD for the heavy and 25 kD for the light chain were detected (data not shown).
- Table V shows affinity constants of XenoMouse-derived antigen-specific fully human Mabs.
- the affinity constants of XenoMouse-derived human IgG 2 ⁇ Mabs specific to IL-8, EGFR, and TNF- ⁇ were determined by BIAcore or by radioimmunoassay as described in Materials and Methods.
- the values shown for LL-8 and EGFR are representative of independent experiments carried out with purified antibodies, while the values shown for TNF- ⁇ are from experiments carried out with hybridoma supernatants.
- the sequences of the heavy and kappa light chain transcripts from the described IL-8 and EGFR-human Mabs were determined Figure 6 and Figures [[ ]]
- the four IL-8-specific antibodies consisted of at least three different V H genes (V H4 . 34 /V H4 . 2 ⁇ , V ⁇ . ⁇ and V H5 . 5 ⁇ ), four different D H segments (A1/A4, Kl, ir3rc, and 21-10rc) and two J H (J ⁇ and J H4 ) gene segments
- Three different VK genes (012, 018, and B3) combined with J ⁇ 3 and J ⁇ 4 genes
- Xenomouse II is capable of producing a panel of anti-LL-8 neutralizing antibodies with diverse variable regions.
- the sequences of antibodies selected for their ability to compete with Mab 225 showed relatively restricted V H and VK gene usage, with three antibodies, El.1, E2.4 and E2.5 sharing the same V H gene (4-31) and E2.11 containing V H4-61 , which is highly homologous to V H -31 .
- Different D (2, A1/A4, XP1) and J H (J H 3, J H 4, J H 5) segments were detected.
- Al l four antibodies were shown to share the same VK (018) gene. Three of them contained J ⁇ 4, and one, E2.5, contained J ⁇ 2.
- V H and VK hybridoma transcripts showed extensive nucleotide changes (7- 17) from the conesponding germline segments, whereas no mutations were detected in the constant regions.
- Most of the mutations in V segments resulted in amino acid substitutions in the predicted antibody amino acid sequences (0-12 per V gene), many in CDR1 and CDR2 regions ( Figure _).
- the mutations which are shared by the heavy chain sequences of EGFR antibodies such as the Gly- Asp substitution in CDR1, shared by all antibodies, or Ser- Asn substitution in CDR2 and Val-Leu in the framework region 3 shared by three antibodies.
- This present application describes the first functional substitution of complex, megabase-sized mouse loci, with human DNA fragments equivalent in size and content reconstructed on YACs.
- the mouse humoral immune system was "humanized” with megabase-sized human Ig loci to substantially reproduce the human antibody response in mice deficient in endogenous antibody production.
- the ratio of human K to mouse ⁇ light chain expression by circulating B-cells provides a useful internal measure of the utilization of the transgenic kappa chain locus
- m mice containing one allele of smaller Ig YACs an approximately equal dist ⁇ bution of human K and mouse ⁇ was observed, a significant preponderance of human K was detected in Xenomouse II strains
- animals homozygous for yK2 possessed a K ⁇ ratio that is identical to wild type mice
- Xenomouse II strains exhibited highly increased antibody diversity with V, D, and J genes across the entire span of the loci accessed by the recombination mechanism and incorporated into mature antibodies. Once triggered by antigen binding, extensive somatic hypermutation occurs, leading to affinity maturation of the antibodies.
- V, D, J genes in Xenomouse II are available and utilized in a manner reminiscent of their utilization in humans, yielding an adult-like human antibody repertoire, which is different from the fetal-like, position-biased usage observed in Ig minigene-bearing mice (Taylor et al., 1992; Taylor et al., 1994; Tuaillon et al., 1993).
- the broad utilization of many of the functional V H and VK genes together with the multiplicity of antigens recognized by the mice underscores the importance of the large V gene repertoire to successfully reconstituting a functional antibody response.
- mice The ultimate test for the extent of reconstitution of the human immune response in mice is the spectrum of antigens to which the mice will elicit an antibody response and the ease with which antigen-specific high affinity Mabs can be generated to different antigens.
- mice engineered with smaller human Ig YACs or minigenes which yielded to date only a limited number of antigen-specific human Mabs (Lonberg et al., 1994; Green et al., 1994; Fishwild et al., 1996)
- Xenomouse II generated Mabs to all human antigens tested to date.
- Xenomouse II strains mounted a strong human antibody response to different human antigens, presented either as soluble proteins or expressed on the surfaces of cells.
- Fully human antibodies are expected to minimize the immunogenic and allergic responses intrinsic to mouse or mouse-derivatized Mabs and thus to increase the efficacy and safety of the administered antibodies
- Xenomouse II offers the opportunity of providing a substantial advantage in the treatment of chronic and recurring human diseases, such as inflammation, autoimmunity, and cancer, which require repeated antibody administrations
- the rapidity and reproducibility with which XenoMouse II yields a panel of fully human high affinity antibodies indicates the potential advance it offers over other technologies for human antibody production.
- Xenomouse II antibodies are high affinity fully intact immunoglobulins which can be produced from hybridomas without further engineering.
- the strategy described here for creation of an authentic human humoral immune system in mice can be applied towards humanization of other multi-gene loci, such as the T cell receptor or the major histocompatibility complex, that govern other compartments of the mouse immune system (Jakobovits, 1994) Such mice would be valuable for elucidating the structure-function relationships of the human loci and their involvement in the evolution of the immune system.
- T ⁇ lie Gly T ⁇ Va. j-g Gin Met Pro Gly Lys Gly Leu Glu T ⁇ Met
- Val Ser Gly Gly Ser lie Ser Ser Gly Asp Tyr Tyr T ⁇ Thr T ⁇ He 1 5 10 15
Abstract
Description
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CA2273194A CA2273194C (en) | 1996-12-03 | 1997-12-03 | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
EP97953227A EP0942968B1 (en) | 1996-12-03 | 1997-12-03 | Fully human antibodies that bind EGFR |
DK97953227T DK0942968T3 (en) | 1996-12-03 | 1997-12-03 | Fully human antibodies that bind EGFR |
JP52590998A JP4215172B2 (en) | 1996-12-03 | 1997-12-03 | Transgenic mammal having human Ig locus comprising a plurality of V {lower H} and V {lower κ} regions, and antibodies produced therefrom |
AU57022/98A AU5702298A (en) | 1996-12-03 | 1997-12-03 | Transgenic mammals having human Ig loci including plural VH and VK regions nd antibodies produced therefrom |
DE69738539T DE69738539T2 (en) | 1996-12-03 | 1997-12-03 | Fully human antibodies bind the EGFR |
HK00101647A HK1022720A1 (en) | 1996-12-03 | 2000-03-17 | Fully human antibodies that bind egfr |
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WO2004073656A2 (en) | 2003-02-20 | 2004-09-02 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
WO2004084823A2 (en) | 2003-03-19 | 2004-10-07 | Abgenix, Inc. | Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof |
WO2005016111A2 (en) | 2003-08-08 | 2005-02-24 | Abgenix, Inc. | Antibodies directed to parathyroid hormone (pth) and uses thereof |
WO2005019463A1 (en) * | 2003-08-11 | 2005-03-03 | Therapeutic Human Polyclonals, Inc. | Improved transgenesis with humanized immunoglobulin loci |
US6893818B1 (en) | 1999-10-28 | 2005-05-17 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
WO2005060739A1 (en) * | 2003-12-24 | 2005-07-07 | G2 Inflammation Pty Ltd | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized c5ar |
WO2005062972A2 (en) | 2003-12-23 | 2005-07-14 | Tanox, Inc. | Treatment of cancer with novel anti-il 13 monoclonal antibodies |
WO2005077042A2 (en) | 2004-02-09 | 2005-08-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1572900A2 (en) * | 2002-01-07 | 2005-09-14 | Abgenix, Inc. | Antibodies directed to pdgfd and uses thereof |
WO2005092926A2 (en) | 2004-03-19 | 2005-10-06 | Amgen Inc. | Reducing the risk of human and anti-human antibodies through v gene manipulation |
WO2005117967A2 (en) | 2004-04-12 | 2005-12-15 | Medimmune, Inc. | Anti-il-9 antibody formulations and uses thereof |
WO2005118864A2 (en) | 2004-05-28 | 2005-12-15 | Agensys, Inc. | Antibodies and related molecules that bind to psca proteins |
US6984720B1 (en) | 1999-08-24 | 2006-01-10 | Medarex, Inc. | Human CTLA-4 antibodies |
WO2006003179A2 (en) | 2004-07-01 | 2006-01-12 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
US7037498B2 (en) | 2001-01-05 | 2006-05-02 | Abgenix, Inc. | Antibodies to insulin-like growth factor I receptor |
US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO2006055638A2 (en) | 2004-11-17 | 2006-05-26 | Abgenix, Inc. | Fully human monoclonal antibodies to il-13 |
WO2006056492A1 (en) | 2004-11-29 | 2006-06-01 | Bioxell Spa | Therapeutic peptides comprising sequences derived from cdr2 or cdr3 of trem-1 and uses thereof to inhibit sepsis |
NL1027009C2 (en) * | 2003-09-10 | 2006-06-19 | Warner Lambert Co | Antibodies to M-CSF. |
US7067131B2 (en) | 2001-12-28 | 2006-06-27 | Abgenix, Inc. | Methods for using anti-MUC18 antibodies |
WO2006068975A2 (en) | 2004-12-20 | 2006-06-29 | Abgenix, Inc. | Binding proteins specific for human matriptase |
US7078492B2 (en) | 2001-05-16 | 2006-07-18 | Abgenix, Inc. | Human antipneumococcal antibodies from non-human animals |
WO2006083286A2 (en) | 2004-06-01 | 2006-08-10 | Mount Sinai School Of Medicine Of New York University | Genetically engineered swine influenza virus and uses thereof |
US7090844B2 (en) | 2001-12-28 | 2006-08-15 | Abgenix, Inc. | Use of antibodies against the MUC18 antigen |
WO2006089133A2 (en) | 2005-02-15 | 2006-08-24 | Duke University | Anti-cd19 antibodies and uses in oncology |
US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
US7141653B2 (en) | 2002-03-29 | 2006-11-28 | Schering Corporation | Human monoclonal antibodies to interleukin-5 |
WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
WO2007024715A2 (en) | 2005-08-19 | 2007-03-01 | Abbott Laboratories | Dual variable domain immunoglobin and uses thereof |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
WO2007056352A2 (en) | 2005-11-07 | 2007-05-18 | The Scripps Research Institute | Compositions and methods for controlling tissue factor signaling specificity |
WO2007059082A1 (en) | 2005-11-10 | 2007-05-24 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen |
EP1792989A1 (en) | 1999-04-12 | 2007-06-06 | Agensys, Inc. | 13 Transmembrane protein expressed in prostate cancer |
WO2007068895A1 (en) | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer |
WO2007077028A2 (en) | 2005-12-30 | 2007-07-12 | U3 Pharma Ag | Antibodies directed to her-3 and uses thereof |
US7244565B2 (en) | 2002-04-10 | 2007-07-17 | Georgetown University | Gene shinc-3 and diagnostic and therapeutic uses thereof |
EP1854885A2 (en) | 1997-11-21 | 2007-11-14 | Serono Genetics Institute S.A. | Chlamydia pneumoniae genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
WO2007147090A2 (en) | 2006-06-14 | 2007-12-21 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity |
EP1874820A2 (en) * | 2005-04-20 | 2008-01-09 | Amgen Fremont Inc. | High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies |
WO2008003319A1 (en) | 2006-07-04 | 2008-01-10 | Genmab A/S | Cd20 binding molecules for the treatment of copd |
US7351811B2 (en) | 2001-04-06 | 2008-04-01 | Georgetown University | Gene SCC-112 and diagnostic and therapeutic uses thereof |
US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
WO2008073300A2 (en) | 2006-12-08 | 2008-06-19 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angptl3 |
US7393534B2 (en) | 2003-07-15 | 2008-07-01 | Barros Research Institute | Compositions and methods for immunotherapy of cancer and infectious diseases |
US7393919B2 (en) | 2005-05-25 | 2008-07-01 | Cure Dm, Inc. | Peptides, derivatives and analogs thereof, and methods of using same |
WO2008081008A1 (en) | 2007-01-05 | 2008-07-10 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
US7402730B1 (en) | 2005-02-03 | 2008-07-22 | Lexicon Pharmaceuticals, Inc. | Knockout animals manifesting hyperlipidemia |
WO2008105797A2 (en) | 2006-06-30 | 2008-09-04 | Bristol-Myers Squibb Company | Polynucleotides encoding novel pcsk9 variants |
WO2008112269A2 (en) | 2007-03-13 | 2008-09-18 | Amgen Inc. | K-ras mutations and anti-egfr antibody therapy |
WO2008118324A2 (en) | 2007-03-26 | 2008-10-02 | Macrogenics, Inc. | Composition and method of treating cancer with an anti-uroplakin ib antibody |
US20080254021A1 (en) * | 2003-08-12 | 2008-10-16 | Dyax Corp. | Tie1-binding ligands |
US7452535B2 (en) | 2002-04-12 | 2008-11-18 | Medarex, Inc. | Methods of treatment using CTLA-4 antibodies |
EP1992695A2 (en) | 1999-08-12 | 2008-11-19 | Agensys, Inc. | C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof |
EP1997829A1 (en) | 2001-12-21 | 2008-12-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2003202A2 (en) | 1999-10-05 | 2008-12-17 | Agensys, Inc. | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
WO2008157379A2 (en) | 2007-06-21 | 2008-12-24 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
WO2009005726A1 (en) | 2007-06-29 | 2009-01-08 | Amgen Inc. | Antigen binding proteins that bind par-2 |
EP2022797A2 (en) | 2000-08-28 | 2009-02-11 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer |
EP2027874A2 (en) | 2000-11-28 | 2009-02-25 | Medimmune, Inc. | Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment |
WO2009033121A2 (en) | 2007-09-06 | 2009-03-12 | University Of Washington | Molecules and methods for treatment and detection of diabetes |
EP2042594A1 (en) | 2000-11-17 | 2009-04-01 | Kirin Pharma Kabushiki Kaisha | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
EP2042518A2 (en) | 2000-06-29 | 2009-04-01 | Abbott Laboratories | Dual specificity antibodies and methods of making and using |
WO2009040134A1 (en) | 2007-09-26 | 2009-04-02 | U3 Pharma Gmbh | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
WO2009054873A2 (en) | 2007-08-02 | 2009-04-30 | Novimmune S.A. | Anti-rantes antibodies and methods of use thereof |
EP2058408A2 (en) | 2003-02-14 | 2009-05-13 | Sagres Discovery, Inc. | Therapeutic GPCR targets in cancer |
WO2009061818A1 (en) | 2007-11-05 | 2009-05-14 | Medimmune, Llc | Methods of treating scleroderma |
WO2009064944A2 (en) | 2007-11-16 | 2009-05-22 | Nuvelo, Inc. | Antibodies to lrp6 |
EP2062591A1 (en) | 2005-04-07 | 2009-05-27 | Novartis Vaccines and Diagnostics, Inc. | CACNA1E in cancer diagnosis detection and treatment |
US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
EP2075582A2 (en) | 2000-07-12 | 2009-07-01 | Agensys, Inc. | Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers |
WO2009085200A2 (en) | 2007-12-21 | 2009-07-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
WO2009086003A1 (en) | 2007-12-20 | 2009-07-09 | Xoma Technology Ltd. | Methods for the treatment of gout |
EP2080766A1 (en) | 2001-06-06 | 2009-07-22 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides useful for immunomodulation |
EP2080802A2 (en) | 1998-06-01 | 2009-07-22 | Agensys, Inc. | Novel serpentine transmembrane antigens expressed in human cancers and uses thereof |
WO2009092011A1 (en) | 2008-01-18 | 2009-07-23 | Medimmune, Llc | Cysteine engineered antibodies for site-specific conjugation |
EP2083088A2 (en) | 2005-04-07 | 2009-07-29 | Novartis Vaccines and Diagnostics, Inc. | Cancer-related genes |
WO2009094551A1 (en) | 2008-01-25 | 2009-07-30 | Amgen Inc. | Ferroportin antibodies and methods of use |
EP2087908A1 (en) | 2001-06-26 | 2009-08-12 | Amgen, Inc. | Antibodies to opgl |
WO2009098700A1 (en) | 2008-02-10 | 2009-08-13 | Yeda Research And Development Co. Ltd | Siva 3, its preparation and use |
WO2009100309A2 (en) | 2008-02-08 | 2009-08-13 | Medimmune, Llc | Anti-ifnar1 antibodies with reduced fc ligand affinity |
EP2090657A2 (en) | 2000-08-07 | 2009-08-19 | Centocor Ortho Biotech Inc. | Anti-IL-12 antibodies, compositions, methods and uses |
EP2093233A1 (en) | 2002-03-21 | 2009-08-26 | Sagres Discovery, Inc. | Novel compositions and methods in cancer |
EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
WO2009118300A1 (en) | 2008-03-25 | 2009-10-01 | Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by down-regulating frizzled-4 and/or frizzled-1 |
EP2112166A2 (en) | 1998-12-23 | 2009-10-28 | Pfizer Inc. | Human monoclonal antibodies to CTLA-4 |
WO2009131203A1 (en) | 2008-04-25 | 2009-10-29 | 東レ株式会社 | Nucleic acid containing chimeric gene derived from hepatitis type-c virus |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2116556A1 (en) | 2008-05-09 | 2009-11-11 | Abbott GmbH & Co. KG | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
WO2009139822A1 (en) | 2008-05-01 | 2009-11-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
EP2128270A1 (en) | 2003-08-08 | 2009-12-02 | Genenews Inc. | Osteoarthritis biomarkers and uses thereof |
US7628986B2 (en) | 2003-06-27 | 2009-12-08 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
WO2009149185A2 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
EP2132984A2 (en) | 2000-06-30 | 2009-12-16 | ZymoGenetics, L.L.C. | Interferon-like protein ZCYTO21 |
WO2010004438A2 (en) | 2008-06-16 | 2010-01-14 | Patrys Limited | Lm-antibodies, functional fragments, lm-1 target antigen, and methods for making and using same |
EP2159230A1 (en) | 2000-08-07 | 2010-03-03 | Centocor Ortho Biotech Inc. | Anti-TNF antibodies, compositions, methods and uses |
WO2010027364A1 (en) | 2008-09-07 | 2010-03-11 | Glyconex Inc. | Anti-extended type i glycosphingolipid antibody, derivatives thereof and use |
WO2010048615A2 (en) | 2008-10-24 | 2010-04-29 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services, Center For Disease Control And Prevention | Human ebola virus species and compositions and methods thereof |
WO2010054403A1 (en) | 2008-11-10 | 2010-05-14 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
WO2010052288A1 (en) | 2008-11-07 | 2010-05-14 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Teneurin and cancer |
EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
EP2191841A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
EP2191842A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
EP2191843A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
EP2193801A2 (en) | 2006-06-28 | 2010-06-09 | Yeda Research And Development Co. Ltd. | Caspase-8 and inflammation, infection and wound healing |
EP2194130A1 (en) | 1999-12-23 | 2010-06-09 | ZymoGenetics, L.L.C. | Cytokine ZCYTO18 |
EP2199801A2 (en) | 2004-07-14 | 2010-06-23 | The Regents Of The University Of California | Biomarkers for early detection of ovarian cancer |
WO2010070263A1 (en) * | 2008-12-18 | 2010-06-24 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
WO2010075238A1 (en) | 2008-12-23 | 2010-07-01 | Amgen Inc. | Human cgrp receptor binding proteins |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
WO2010072740A2 (en) | 2008-12-23 | 2010-07-01 | Astrazeneca Ab | TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF |
WO2010075548A2 (en) | 2008-12-23 | 2010-07-01 | Genentech, Inc. | Immunoglobulin variants with altered binding to protein a |
US7750125B2 (en) | 2002-06-10 | 2010-07-06 | University Of Rochester | Antibodies that bind to the C35 polypeptide |
EP2204376A2 (en) | 2004-07-20 | 2010-07-07 | Sagres Discovery, Inc. | Novel therapeutic targets in cancer |
WO2010078526A1 (en) | 2008-12-31 | 2010-07-08 | Biogen Idec Ma Inc. | Anti-lymphotoxin antibodies |
WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2010080538A1 (en) | 2008-12-19 | 2010-07-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
WO2010082134A1 (en) | 2009-01-14 | 2010-07-22 | Iq Therapeutics Bv | Combination antibodies for the treatment and prevention of disease caused by bacillus anthracis and related bacteria and their toxins |
WO2010085510A1 (en) | 2009-01-20 | 2010-07-29 | Zadeh Homayoun H | Antibody mediated osseous regeneration |
US7767207B2 (en) | 2000-02-10 | 2010-08-03 | Abbott Laboratories | Antibodies that bind IL-18 and methods of inhibiting IL-18 activity |
EP2213685A1 (en) | 2002-09-06 | 2010-08-04 | Amgen Inc. | Therapeutic anti-IL-1R1 monoclonal antibody |
US7776523B2 (en) | 2000-12-07 | 2010-08-17 | Novartis Vaccines And Diagnostics, Inc. | Endogenous retroviruses up-regulated in prostate cancer |
EP2218732A1 (en) | 1997-11-28 | 2010-08-18 | Merck Serono Biodevelopment | Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
US20100212035A1 (en) * | 2007-06-01 | 2010-08-19 | Omt, Inc. | Compositions and Methods for Producing Transgenic Mammals Having Recombinant Immunoglobulin Loci |
WO2010093993A2 (en) | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
EP2221316A1 (en) | 2005-05-05 | 2010-08-25 | Duke University | Anti-CD19 antibody therapy for autoimmune disease |
US7785829B2 (en) | 2003-03-19 | 2010-08-31 | Biogen Idec Ma, Inc. | Nogo receptor binding protein |
US7790160B2 (en) | 2004-10-01 | 2010-09-07 | Medarex, Inc. | Method of treating CD30 positive lymphomas |
WO2010100247A1 (en) | 2009-03-06 | 2010-09-10 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Novel therapy for anxiety |
US7795494B2 (en) | 2001-03-22 | 2010-09-14 | Abbott Laboratories | Transgenic mice expressing antibodies specific for genes of interest and uses thereof |
EP2228389A2 (en) | 2001-04-13 | 2010-09-15 | Human Genome Sciences, Inc. | Antibodies against vascular endothelial growth factor 2 |
EP2230299A1 (en) | 2002-01-18 | 2010-09-22 | ZymoGenetics, Inc. | Novel cytokine ZCYTOR17 ligand |
WO2010108127A1 (en) | 2009-03-20 | 2010-09-23 | Genentech, Inc. | Bispecific anti-her antibodies |
WO2010108153A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
US7803377B2 (en) | 2006-06-06 | 2010-09-28 | Genentech, Inc. | Anti-DLL4 antibodies and methods using same |
WO2010111180A1 (en) | 2009-03-24 | 2010-09-30 | Teva Biopharmaceuticals Usa, Inc. | Humanized antibodies against light and uses thereof |
US7807863B2 (en) | 2002-11-08 | 2010-10-05 | Kyowa Hakko Kirin Co., Ltd. | Transgenic bovine having reduced prion protein activity and uses thereof |
US7807159B2 (en) | 2005-04-25 | 2010-10-05 | Amgen Fremont Inc. | Antibodies to myostatin |
US7807798B2 (en) | 1997-05-05 | 2010-10-05 | Amgen Fremont Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
EP2236519A1 (en) | 2007-09-18 | 2010-10-06 | Amgen, Inc | Human GM-CSF antigen binding proteins |
WO2010114859A1 (en) | 2009-04-01 | 2010-10-07 | Genentech, Inc. | Treatment of insulin-resistant disorders |
EP2238986A2 (en) | 2005-07-08 | 2010-10-13 | Biogen Idec MA Inc. | Sp35 antibodies and uses thereof |
WO2010118243A2 (en) | 2009-04-08 | 2010-10-14 | Genentech, Inc. | Use of il-27 antagonists to treat lupus |
WO2010117057A1 (en) | 2009-04-10 | 2010-10-14 | 協和発酵キリン株式会社 | Method for treatment of blood tumor using anti-tim-3 antibody |
WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
EP2241323A1 (en) | 2009-04-14 | 2010-10-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Tenascin-W and brain cancers |
EP2241330A1 (en) | 2003-02-14 | 2010-10-20 | The Curators Of The University Of Missouri | Contraceptive methods and compositions related to proteasomal interference |
US7820877B2 (en) | 1996-12-03 | 2010-10-26 | Amgen Fremont Inc. | Transgenic mammals having human IG loci including plural Vh and Vk regions and antibodies produced therefrom |
EP2246363A1 (en) | 2002-11-15 | 2010-11-03 | Novartis Vaccines and Diagnostics, Inc. | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
WO2010126066A1 (en) | 2009-04-27 | 2010-11-04 | 協和発酵キリン株式会社 | Anti-il-3rα antibody for use in treatment of blood tumor |
WO2010128407A2 (en) | 2009-05-05 | 2010-11-11 | Novimmune S.A. | Anti-il-17f antibodies and methods of use thereof |
EP2251034A1 (en) | 2005-12-02 | 2010-11-17 | Mount Sinai School of Medicine of New York University | Chimeric Newcastle Disease viruses presenting non-native surface proteins and uses thereof |
EP2253646A1 (en) | 2000-08-07 | 2010-11-24 | Centocor Ortho Biotech Inc. | Anti-dual integrin antibody and compositions and conjugates comprising said antibody |
US7846434B2 (en) | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
EP2258725A2 (en) | 2000-06-26 | 2010-12-08 | ZymoGenetics, L.L.C. | Cytokine receptor zcytor17 |
EP2264163A2 (en) | 2001-02-16 | 2010-12-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
WO2010148223A2 (en) | 2009-06-17 | 2010-12-23 | Facet Biotech Corporation | Anti-vegf antibodies and their uses |
WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
US7868140B2 (en) | 2005-07-18 | 2011-01-11 | Amgen Inc. | Human anti-B7RP1 neutralizing antibodies |
US7867494B2 (en) | 2007-04-02 | 2011-01-11 | Amgen Fremont Inc. | Anti-IgE antibodies |
WO2011006001A1 (en) | 2009-07-09 | 2011-01-13 | Genentech, Inc. | Animal model for the evaluation of adjuvant therapies of cancer |
WO2011008696A2 (en) | 2009-07-13 | 2011-01-20 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
EP2280030A2 (en) | 2001-04-10 | 2011-02-02 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
WO2011014645A1 (en) | 2009-07-30 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Influenza viruses and uses thereof |
WO2011014457A1 (en) | 2009-07-27 | 2011-02-03 | Genentech, Inc. | Combination treatments |
WO2011014504A1 (en) | 2009-07-27 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Recombinant influenza virus vectors and uses thereof |
WO2011014750A1 (en) | 2009-07-31 | 2011-02-03 | Genentech, Inc. | Inhibition of tumor metastasis using bv8- or g-csf-antagonists |
EP2284194A1 (en) | 2004-12-21 | 2011-02-16 | AstraZeneca AB | Antibodies directed to angiopoietin-2 and uses thereof |
WO2011019619A1 (en) | 2009-08-11 | 2011-02-17 | Genentech, Inc. | Production of proteins in glutamine-free cell culture media |
WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
WO2011020049A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Biological markers for monitoring patient response to vegf antagonists |
WO2011020079A1 (en) | 2009-08-13 | 2011-02-17 | Calmune Corporation | Antibodies against human respiratory syncytial virus (rsv) and methods of use |
WO2011019620A1 (en) | 2009-08-10 | 2011-02-17 | Genentech, Inc. | Antibodies with enhanced adcc function |
EP2287186A1 (en) | 2001-09-06 | 2011-02-23 | Agensys, Inc. | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
EP2289909A1 (en) | 2005-11-30 | 2011-03-02 | Abbott Laboratories | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
WO2011025964A2 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
EP2292266A1 (en) | 2009-08-27 | 2011-03-09 | Novartis Forschungsstiftung, Zweigniederlassung | Treating cancer by modulating copine III |
EP2292663A2 (en) | 2006-08-28 | 2011-03-09 | Kyowa Hakko Kirin Co., Ltd. | Antagonistic human light-specific human monoclonal antibodies |
EP2292636A2 (en) | 2004-09-09 | 2011-03-09 | Genentech, Inc. | Process for concentration of antibodies and therapeutic products thereof |
WO2011028950A1 (en) | 2009-09-02 | 2011-03-10 | Genentech, Inc. | Mutant smoothened and methods of using the same |
EP2295577A2 (en) | 1999-03-09 | 2011-03-16 | ZymoGenetics, Inc. | Human cytokine as ligand of the z-alpha receptor and uses thereof |
EP2295465A2 (en) | 2004-12-06 | 2011-03-16 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibodies to influenza M2 protein and methods of making and using same |
WO2011032013A1 (en) | 2009-09-11 | 2011-03-17 | Genentech, Inc. | Method to identify a patient with an increased likelihood of responding to an anti-cancer agent |
US7910798B2 (en) | 2006-03-31 | 2011-03-22 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
EP2298348A1 (en) | 2000-04-14 | 2011-03-23 | Millennium Pharmaceuticals, Inc. | Antibody binding alpha4Beta7 integrin and its use to treat inflammatory bowel disease |
WO2011033006A1 (en) | 2009-09-17 | 2011-03-24 | F. Hoffmann-La Roche Ag | Methods and compositions for diagnostics use in cancer patients |
EP2301954A2 (en) | 2002-08-16 | 2011-03-30 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 282P1G3 useful in treatment and detection of cancer |
EP2302041A1 (en) | 2001-11-07 | 2011-03-30 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
WO2011038301A2 (en) | 2009-09-25 | 2011-03-31 | Xoma Technology Ltd. | Screening methods |
WO2011038302A2 (en) | 2009-09-25 | 2011-03-31 | Xoma Technology Ltd. | Novel modulators |
WO2011036118A1 (en) | 2009-09-22 | 2011-03-31 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mex-3 |
WO2011039724A1 (en) | 2009-10-02 | 2011-04-07 | Sanofi-Aventis | Antibodies that specifically bind to the epha2 receptor |
WO2011041336A2 (en) | 2009-09-30 | 2011-04-07 | Genentech, Inc. | Methods of treating cancer using notch antagonists |
WO2011044205A1 (en) | 2009-10-07 | 2011-04-14 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
WO2011044368A1 (en) | 2009-10-07 | 2011-04-14 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
US7928285B2 (en) | 2004-04-22 | 2011-04-19 | Kyowa Hakko Kirin Co., Ltd. | Method of producing xenogenous antibodies using a bovine |
EP2311477A1 (en) | 2006-03-20 | 2011-04-20 | Japan Science and Technology Agency | Use of ip3 receptor-binding protein for controlling phosphatidylinositol metabolism |
EP2311873A1 (en) | 2004-01-07 | 2011-04-20 | Novartis Vaccines and Diagnostics, Inc. | M-CSF-specific monoclonal antibody and uses thereof |
EP2311491A1 (en) | 2005-03-08 | 2011-04-20 | Pharmacia & Upjohn Company LLC | Composition comprising an antibody against macrophage colony-stimulating factor (M-CSF) and a chelating agent |
EP2311863A1 (en) | 2001-03-05 | 2011-04-20 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer |
WO2011045352A2 (en) | 2009-10-15 | 2011-04-21 | Novartis Forschungsstiftung | Spleen tyrosine kinase and brain cancers |
US7932372B2 (en) | 2004-01-09 | 2011-04-26 | Amgen Fremont Inc. | Antibodies to MAdCAM |
EP2314316A1 (en) | 2002-04-05 | 2011-04-27 | Amgen, Inc | Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors |
WO2011049758A1 (en) | 2009-10-09 | 2011-04-28 | Amgen Inc. | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors |
EP2316487A1 (en) | 2003-04-11 | 2011-05-04 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
WO2011051392A1 (en) | 2009-10-30 | 2011-05-05 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Phosphorylated twist1 and cancer |
EP2319925A2 (en) | 2004-08-16 | 2011-05-11 | Quark Pharmaceuticals, Inc. | Therapeutic uses of inhibitors of RTP801 |
EP2319941A2 (en) | 2005-10-21 | 2011-05-11 | GeneNews Inc. | Method and apparatus for correlating levels of biomarker products with disease |
EP2319524A1 (en) | 2003-05-30 | 2011-05-11 | Agensys, Inc. | Prostate stem cell antigen (PSCA) variants and subsequences thereof |
WO2011056502A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use |
WO2011056073A2 (en) | 2009-11-04 | 2011-05-12 | Erasmus University Medical Center Rotterdam | Novel compounds for modulating neovascularisation and methods of treatment using these compounds |
WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
WO2011056497A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
WO2011056600A1 (en) | 2009-10-26 | 2011-05-12 | Amgen Inc. | Human il-23 antigen binding proteins |
EP2322215A2 (en) | 2004-07-16 | 2011-05-18 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody |
EP2322561A1 (en) | 2003-10-07 | 2011-05-18 | Yeda Research And Development Co., Ltd. | Anti-NIK antibodies and uses thereof |
WO2011059762A1 (en) | 2009-10-28 | 2011-05-19 | Abbott Biotherapeutics Corp. | Anti-egfr antibodies and their uses |
WO2011058321A1 (en) | 2009-11-11 | 2011-05-19 | King's College Hospital Nhs Foundation Trust | Conjugate molecule |
WO2011060206A2 (en) | 2009-11-13 | 2011-05-19 | U3 Pharma Gmbh | Material and methods for treating or preventing her-3 associated diseases |
WO2011060015A1 (en) | 2009-11-11 | 2011-05-19 | Genentech, Inc. | Methods and compositions for detecting target proteins |
EP2325208A1 (en) | 2005-12-15 | 2011-05-25 | Genentech, Inc. | Polyubiquitin antibodies |
WO2011063277A1 (en) | 2009-11-20 | 2011-05-26 | Amgen Inc. | Anti-orai1 antigen binding proteins and uses thereof |
EP2329714A1 (en) | 2004-08-03 | 2011-06-08 | Biogen Idec MA Inc. | Influence of TAJ in the neuronal functions |
WO2011070045A1 (en) | 2009-12-08 | 2011-06-16 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
WO2011071783A1 (en) | 2009-12-07 | 2011-06-16 | Amgen Inc. | Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof |
WO2011071577A1 (en) | 2009-12-11 | 2011-06-16 | Genentech, Inc. | Anti-vegf-c antibodies and methods using same |
US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
EP2336161A2 (en) | 2003-01-31 | 2011-06-22 | Abbott GmbH & Co. KG | Amyloid-beta(1-42) oligomers, derivatives thereof, antibodies for the same, method for production and use thereof. |
EP2336177A1 (en) | 2004-08-04 | 2011-06-22 | Amgen, Inc | Antibodies to DKK-1 |
EP2338910A1 (en) | 2002-01-18 | 2011-06-29 | ZymoGenetics, Inc. | Cytokine receptor Zcytor17 multimers |
WO2011079185A1 (en) | 2009-12-23 | 2011-06-30 | Genentech, Inc. | Anti-bv8 antibodies and uses thereof |
EP2341060A1 (en) | 2000-12-12 | 2011-07-06 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
EP2341067A1 (en) | 2003-07-18 | 2011-07-06 | Amgen, Inc | Specific binding agents to hepatocyte growth factor |
EP2343086A2 (en) | 2001-11-09 | 2011-07-13 | Pfizer Products Inc. | Antibodies to CD40 |
EP2343315A2 (en) | 2003-02-10 | 2011-07-13 | Agensys, Inc. | Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers |
WO2011084496A1 (en) | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
WO2011085343A1 (en) | 2010-01-11 | 2011-07-14 | Alexion Pharmaceuticals, Inc | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
WO2011084750A1 (en) | 2009-12-21 | 2011-07-14 | Genentech, Inc. | Antibody formulation |
US7981418B2 (en) | 2007-03-02 | 2011-07-19 | Genentech, Inc. | Predicting response to a HER inhibitor |
EP2357192A1 (en) | 1999-02-26 | 2011-08-17 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
EP2357202A1 (en) | 2006-04-10 | 2011-08-17 | AstraZeneca AB | Targeted binding agents directed to Upar and uses thereof |
WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
US8007995B2 (en) | 2005-11-10 | 2011-08-30 | Bristol-Myers Squibb Company | Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers |
EP2361933A2 (en) | 2005-01-26 | 2011-08-31 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
EP2361934A2 (en) | 2006-06-02 | 2011-08-31 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (HGF) binding proteins |
WO2011107586A1 (en) | 2010-03-05 | 2011-09-09 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research, | Smoc1, tenascin-c and brain cancers |
EP2365081A2 (en) | 1999-04-12 | 2011-09-14 | Agensys, Inc. | 13 Transmembrane protein expressed in prostate cancer |
EP2366715A2 (en) | 2005-11-14 | 2011-09-21 | Amgen Inc. | Rankl Antibody-PTH/PTHRP Chimeric Molecules |
EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
US8030457B2 (en) | 2007-08-23 | 2011-10-04 | Amgen, Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
EP2371389A2 (en) | 2002-08-14 | 2011-10-05 | MacroGenics, Inc. | FcgammaRIIB-specific antibodies and methods of use thereof |
WO2011130377A2 (en) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
WO2011130417A2 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS |
EP2380908A1 (en) | 2006-06-02 | 2011-10-26 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (hgf) binding proteins |
WO2011133931A1 (en) | 2010-04-22 | 2011-10-27 | Genentech, Inc. | Use of il-27 antagonists for treating inflammatory bowel disease |
WO2011131611A1 (en) | 2010-04-19 | 2011-10-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Modulating xrn1 |
WO2011137395A1 (en) | 2010-04-30 | 2011-11-03 | Rother Russell P | Anti-c5a antibodies and methods for using the antibodies |
EP2385070A1 (en) | 2003-11-12 | 2011-11-09 | Abbott Laboratories | Il-18 binding proteins |
WO2011138776A2 (en) | 2010-05-06 | 2011-11-10 | Hervana Ltd. | Biologic female contraceptives |
US8058406B2 (en) | 2008-07-09 | 2011-11-15 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
EP2386655A2 (en) | 2006-09-12 | 2011-11-16 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of lung cancer using KIT or KDG gene as genetic marker |
WO2011141823A2 (en) | 2010-05-14 | 2011-11-17 | Orega Biotech | Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists |
WO2011143562A2 (en) | 2010-05-14 | 2011-11-17 | Abbott Laboratories | Il-1 binding proteins |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
US8071323B2 (en) | 2006-04-07 | 2011-12-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human monoclonal antibodies that bind human insulin like growth factors and their use |
WO2011153224A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2011153346A1 (en) | 2010-06-03 | 2011-12-08 | Genentech, Inc. | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
WO2011154485A1 (en) | 2010-06-10 | 2011-12-15 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mammalian sterile 20-like kinase 3 |
EP2399605A1 (en) | 2005-02-23 | 2011-12-28 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
WO2011161427A2 (en) | 2010-06-25 | 2011-12-29 | Aston University | Glycoproteins having lipid mobilizing properties and therapeutic uses thereof |
US8088377B2 (en) | 2002-01-09 | 2012-01-03 | Medarex, Inc. | Human monoclonal antibodies against CD30 |
EP2402443A2 (en) | 2006-01-20 | 2012-01-04 | Quark Pharmaceuticals, Inc. | Therapeutic uses of inhibitors of rtp801 |
EP2404616A2 (en) | 2005-12-13 | 2012-01-11 | AstraZeneca AB | Binding proteins specific for insulin-like growth factors and uses thereof |
WO2012006596A2 (en) | 2010-07-09 | 2012-01-12 | Calmune Corporation | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
WO2012006500A2 (en) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Monoclonal antibodies against hepatitis c virus core protein |
EP2407483A1 (en) | 2006-04-13 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Methods of treating, diagnosing or detecting cancers |
EP2407548A1 (en) | 2006-10-16 | 2012-01-18 | MedImmune, LLC | Molecules with reduced half-lives, compositions and uses thereof |
WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
WO2012010548A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010321A1 (en) | 2010-07-23 | 2012-01-26 | Erasmus University Medical Center Rotterdam | Foetal haemoglobin inhibitor |
WO2012012141A1 (en) | 2010-06-30 | 2012-01-26 | Amgen Inc. | Scnn1a/tnfrsf1a fusion proteins in cancer |
WO2012010549A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010855A1 (en) | 2010-07-23 | 2012-01-26 | Medical Research Council | Intracellular immunity |
EP2412828A1 (en) | 2007-03-13 | 2012-02-01 | Amgen Inc. | K-ras and B-raf mutations and anti-EGFr antibody therapy |
WO2012018687A1 (en) | 2010-08-02 | 2012-02-09 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
WO2012018404A2 (en) | 2010-08-06 | 2012-02-09 | U3 Pharma Gmbh | Use of her3 binding agents in prostate treatment |
US8114606B2 (en) | 2007-02-16 | 2012-02-14 | The Board Of Trustees Of Southern Illinois University | ARL-1 specific antibodies |
WO2012021648A1 (en) | 2010-08-10 | 2012-02-16 | Amgen Inc. | Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies |
EP2420514A1 (en) | 2006-08-03 | 2012-02-22 | MedImmune Limited | Targeted binding agents directed to PDGFR-alpha and uses thereof |
WO2012024650A2 (en) | 2010-08-19 | 2012-02-23 | Abbott Laboratories | Anti-ngf antibodies and their use |
EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
EP2423231A2 (en) | 2006-08-18 | 2012-02-29 | Novartis AG | PRLR-specific antibody and uses thereof |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
WO2012032143A1 (en) | 2010-09-10 | 2012-03-15 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Phosphorylated twist1 and metastasis |
EP2431054A2 (en) | 2000-06-15 | 2012-03-21 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
EP2431053A1 (en) | 2006-11-27 | 2012-03-21 | Patrys Limited | Novel glycosylated peptide target in neoplastic cells |
WO2012040518A2 (en) | 2010-09-22 | 2012-03-29 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
EP2436781A1 (en) | 2007-02-22 | 2012-04-04 | Genentech, Inc. | Methods for detecting inflammatory bowel disease |
WO2012047968A2 (en) | 2010-10-05 | 2012-04-12 | Genentech, Inc. | Mutant smoothened and methods of using the same |
EP2444420A1 (en) | 2005-04-26 | 2012-04-25 | Pfizer Inc. | P-Cadherin antibodies |
EP2444099A1 (en) | 2005-03-31 | 2012-04-25 | Agensys, Inc. | Antibodies and related molecules that bind to 161P2F10B proteins |
WO2012054748A2 (en) | 2010-10-22 | 2012-04-26 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
EP2446904A2 (en) | 2006-05-30 | 2012-05-02 | Genentech, Inc. | Anti-CD22 antibodies, their immunoconjugates and uses thereof |
EP2447275A1 (en) | 2006-07-13 | 2012-05-02 | University of Iowa Research Foundation | Methods and reagents for treatment of age-related macular degeneration |
EP2447283A2 (en) | 2005-09-07 | 2012-05-02 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1) |
WO2012058393A2 (en) | 2010-10-27 | 2012-05-03 | Amgen Inc. | Dkk1 antibodies and methods of use |
EP2452694A1 (en) | 2005-06-30 | 2012-05-16 | Janssen Biotech, Inc. | Anti-IL-23 antibodies, compositions, methods and uses |
WO2012065937A1 (en) | 2010-11-15 | 2012-05-24 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Anti-fungal agents |
WO2012071381A1 (en) | 2010-11-24 | 2012-05-31 | Lexicon Pharmaceuticals, Inc. | Antibodies to notum pectinacetylesterase |
US8193321B2 (en) | 2008-09-03 | 2012-06-05 | Genentech, Inc. | Multispecific antibodies |
EP2463305A1 (en) | 2006-01-12 | 2012-06-13 | Alexion Pharmaceuticals, Inc. | Antibodies to OX-2/CD200 and uses thereof |
WO2012076663A1 (en) | 2010-12-10 | 2012-06-14 | Sanofi | Antitumor combinations containing antibodies recognizing specifically cd38 and bortezomib |
US8207303B2 (en) | 2005-02-18 | 2012-06-26 | Medarex, Inc. | Monoclonal antibodies against CD30 lacking in fucosyl residues |
EP2468776A2 (en) | 2007-02-09 | 2012-06-27 | Genentech, Inc. | Anti-Robo4 antibodies and uses therefor |
WO2012083370A1 (en) | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
WO2012088094A2 (en) | 2010-12-21 | 2012-06-28 | Abbott Laboratories | Il-1 binding proteins |
US8211430B2 (en) | 2005-03-04 | 2012-07-03 | Curedm Group Holdings, Llc | Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions |
EP2471816A1 (en) | 2006-08-30 | 2012-07-04 | Genentech, Inc. | Multispecific antibodies |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
EP2474556A2 (en) | 2007-03-14 | 2012-07-11 | Novartis AG | APCDD1 inhibitors for treating, diagnosing or detecting cancer |
EP2474317A1 (en) | 2004-06-24 | 2012-07-11 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
WO2012094252A1 (en) | 2011-01-03 | 2012-07-12 | The Terasaki Family Foundation | Anti-hla-e antibodies, therapeutic immunomodulatory antibodies to human hla-e heavy chain, useful as ivig mimetics and methods of their use |
WO2012099983A1 (en) | 2011-01-18 | 2012-07-26 | Amgen Inc. | Nav1.7 knockout mice and uses thereof |
WO2012102679A1 (en) | 2011-01-24 | 2012-08-02 | National University Of Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
WO2012103165A2 (en) | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
EP2483309A1 (en) * | 2009-09-29 | 2012-08-08 | Green Cross Corporation | Antibodies specifically binding to the epidermal growth factor receptor |
WO2012106634A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
EP2494988A1 (en) | 2006-12-07 | 2012-09-05 | Novartis AG | Antagonist antibodies against EPHB3 |
WO2012118903A2 (en) | 2011-03-01 | 2012-09-07 | Amgen Inc. | Bispecific binding agents |
WO2012118750A2 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
WO2012121775A2 (en) | 2010-12-21 | 2012-09-13 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
EP2500353A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500030A2 (en) | 2005-11-04 | 2012-09-19 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
WO2012128377A1 (en) | 2011-03-18 | 2012-09-27 | 国立大学法人鹿児島大学 | Composition for treatment and diagnosis of pancreatic cancer |
US8278421B2 (en) | 2006-03-20 | 2012-10-02 | Xoma Techolology Ltd. | Human antibodies specific for gastrin materials and methods |
EP2505209A1 (en) | 2006-06-26 | 2012-10-03 | MacroGenics, Inc. | Fcgamma-RIIB-specific antibodies and methods of the use thereof |
WO2012138997A1 (en) | 2011-04-07 | 2012-10-11 | Amgen Inc. | Novel egfr binding proteins |
EP2510934A1 (en) | 2005-11-04 | 2012-10-17 | Biogen Idec MA Inc. | Methods for promoting neurite outgrowth and survival of dopaminergic neurons |
EP2511301A2 (en) | 2006-08-04 | 2012-10-17 | Medimmune Limited | Human antibodies to ERBB2 |
WO2012145493A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
EP2520669A2 (en) | 2005-02-07 | 2012-11-07 | GeneNews Inc. | Mild osteoathritis biomarkers and uses thereof |
US8309530B2 (en) | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
WO2012154999A1 (en) | 2011-05-10 | 2012-11-15 | Amgen Inc. | Methods of treating or preventing cholesterol related disorders |
EP2526968A2 (en) | 2006-01-27 | 2012-11-28 | Biogen Idec MA Inc. | Nogo receptor antagonists |
EP2527456A1 (en) | 2004-10-22 | 2012-11-28 | Revivicor Inc. | Transgenic porcines lacking endogenous immunoglobulin light chain |
WO2012162531A1 (en) | 2011-05-25 | 2012-11-29 | Bg Medicine, Inc. | Inhibitors of galectin-3 and methods of use thereof |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
WO2012162068A2 (en) | 2011-05-21 | 2012-11-29 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
WO2012167143A1 (en) | 2011-06-03 | 2012-12-06 | Xoma Technology Ltd. | Antibodies specific for tgf-beta |
WO2012170438A2 (en) | 2011-06-06 | 2012-12-13 | Amgen Inc. | HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING β-KLOTHO AND AN FGF RECEPTOR |
WO2012168259A1 (en) | 2011-06-06 | 2012-12-13 | Novartis Forschungsstiftung, Zweigniederlassung | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer |
WO2012170071A1 (en) | 2011-06-06 | 2012-12-13 | Elan Pharmaceuticas, Inc | Mcam antagonists and methods of treatment |
WO2012174534A2 (en) | 2011-06-17 | 2012-12-20 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using clec-2 |
US8337852B2 (en) | 2006-08-22 | 2012-12-25 | G2 Inflammation Pty Ltd | Anti-C5aR antibodies with improved properties |
WO2012175576A1 (en) | 2011-06-20 | 2012-12-27 | Pierre Fabre Medicament | Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer. |
EP2543384A2 (en) | 2005-12-02 | 2013-01-09 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
US8361468B2 (en) | 2008-02-20 | 2013-01-29 | G2 Inflammation Pty Ltd | Humanized anti-C5aR antibodies |
WO2013019906A1 (en) | 2011-08-01 | 2013-02-07 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
WO2013025944A1 (en) | 2011-08-17 | 2013-02-21 | Genentech, Inc. | Inhibition of angiogenesis in refractory tumors |
WO2013025779A1 (en) | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
US8388965B2 (en) | 2007-10-15 | 2013-03-05 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2567973A2 (en) | 2005-11-28 | 2013-03-13 | Zymogenetics, Inc. | IL-21 antagonists |
WO2013034660A1 (en) | 2011-09-09 | 2013-03-14 | Medimmune Limited | Anti-siglec-15 antibodies and uses thereof |
US8398975B2 (en) | 2006-08-03 | 2013-03-19 | Medimmune Limited | Antibodies directed to αVβ6 and uses thereof |
EP2570432A1 (en) | 2002-06-14 | 2013-03-20 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
US8404820B2 (en) | 2003-05-21 | 2013-03-26 | Medarex, Inc. | Human monoclonal antibodies against Bacillus anthracis protective antigen |
EP2573114A1 (en) | 2005-08-10 | 2013-03-27 | MacroGenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
WO2013042426A1 (en) | 2011-09-21 | 2013-03-28 | 富士レビオ株式会社 | Antibody against affinity complex |
WO2013052155A1 (en) | 2011-10-05 | 2013-04-11 | Genentech, Inc. | Methods of treating liver conditions using notch2 antagonists |
US8420083B2 (en) | 2009-10-31 | 2013-04-16 | Abbvie Inc. | Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof |
EP2586788A1 (en) | 2007-07-09 | 2013-05-01 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
WO2013063095A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against sclerostin |
WO2013063114A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against tnf |
EP2589610A1 (en) | 2007-08-21 | 2013-05-08 | Amgen, Inc | Human c-fms antigen binding proteins |
WO2013067054A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Antibodies and methods of treating cancer |
WO2013067055A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
WO2013067057A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
WO2013066491A1 (en) | 2011-09-09 | 2013-05-10 | Amgen Inc. | Use of human papillomavirus status in establishing use of an agent that binds egfr in the treatment of cancer |
WO2013067060A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
WO2013067492A1 (en) | 2011-11-03 | 2013-05-10 | The Trustees Of The University Of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
EP2592156A2 (en) | 2007-06-08 | 2013-05-15 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
WO2013068432A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Early diagnostic of neurodegenerative diseases |
WO2013068902A1 (en) | 2011-11-08 | 2013-05-16 | Pfizer Inc. | Methods of treating inflammatory disorders using anti-m-csf antibodies |
WO2013070821A1 (en) | 2011-11-08 | 2013-05-16 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
WO2013068431A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
EP2594585A1 (en) | 2006-01-10 | 2013-05-22 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using IL-31 antagonists |
WO2013075048A1 (en) | 2011-11-16 | 2013-05-23 | Amgen Inc. | Methods of treating epidermal growth factor deletion mutant viii related disorders |
EP2599793A1 (en) | 2008-05-29 | 2013-06-05 | Nuclea Biotechnologies, Inc. | Anti-phospho-akt antibodies |
WO2013079174A1 (en) | 2011-11-28 | 2013-06-06 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
US8460667B2 (en) | 2006-07-18 | 2013-06-11 | Sanofi | EPHA2 receptor antagonist antibodies |
WO2013086443A1 (en) | 2011-12-08 | 2013-06-13 | Amgen Inc. | Agonistic human lcat antigen binding proteins and their use in therapy |
WO2013083817A1 (en) | 2011-12-08 | 2013-06-13 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
WO2013090635A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
WO2013090633A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
WO2013093809A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
WO2013096516A1 (en) | 2011-12-19 | 2013-06-27 | Xoma Technology Ltd. | Methods for treating acne |
EP2610267A1 (en) | 2006-12-18 | 2013-07-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
EP2612924A2 (en) | 2007-05-21 | 2013-07-10 | Genentech, Inc. | Methods and compositions for indentifying and treating lupus |
WO2013102825A1 (en) | 2012-01-02 | 2013-07-11 | Novartis Ag | Cdcp1 and breast cancer |
EP2614839A2 (en) | 2006-04-05 | 2013-07-17 | Genentech, Inc. | Method for using BOC/CDO to modulate hedgehog signaling |
WO2013106765A1 (en) | 2012-01-13 | 2013-07-18 | Genentech, Inc. | Biological markers for identifying patients for treatment with vegf antagonists |
WO2013106586A2 (en) | 2012-01-11 | 2013-07-18 | The Terasaki Family Foundation | Anti-hla class-ib antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (ivig) useful as therapeutic ivig mimetics and methods of their use |
WO2013106489A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
WO2013106485A2 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
WO2013107290A1 (en) | 2012-01-20 | 2013-07-25 | The Government of the Hong Kong Special Administrative Region of the People's Republic of China | A novel paramyxovirus and uses thereof |
WO2013112922A1 (en) | 2012-01-27 | 2013-08-01 | AbbVie Deutschland GmbH & Co. KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
EP2623516A2 (en) | 2005-12-02 | 2013-08-07 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R |
WO2013116287A1 (en) | 2012-01-31 | 2013-08-08 | Genentech, Inc. | Anti-ig-e m1' antibodies and methods using same |
WO2013117735A1 (en) | 2012-02-09 | 2013-08-15 | Medical Research Council | Conjugate comprising an agent and an antiviral ligand and its use in a method for delivering the agent intracellularly |
US8518694B2 (en) | 2002-06-13 | 2013-08-27 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acid vector comprising a promoter and a sequence encoding a polypeptide from the endogenous retrovirus PCAV |
EP2631302A2 (en) | 2008-03-31 | 2013-08-28 | Genentech, Inc. | Compositions and methods for treating and diagnosing asthma |
WO2013126813A1 (en) | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
WO2013148288A1 (en) | 2012-03-30 | 2013-10-03 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2013148315A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Diagnosis and treatments relating to her3 inhibitors |
WO2013144240A1 (en) | 2012-03-29 | 2013-10-03 | Friedrich Miescher Institute For Biomedical Research | Inhibition of interleukin- 8 and/or its receptor cxcrl in the treatment her2/her3 -overexpressing breast cancer |
WO2013148232A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
US8557239B2 (en) | 2009-09-14 | 2013-10-15 | Abbvie Inc. | Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23 |
WO2013155447A1 (en) | 2012-04-13 | 2013-10-17 | Children's Medical Center Corporation | Tiki inhibitors |
WO2013163377A1 (en) | 2012-04-27 | 2013-10-31 | Novo Nordisk A/S | Human cd30 ligand antigen binding proteins |
WO2013165590A1 (en) | 2012-05-03 | 2013-11-07 | Fibrogen, Inc. | Methods for treating idiopathic pulmonary fibrosis |
WO2013166290A1 (en) | 2012-05-04 | 2013-11-07 | Abbvie Biotherapeutics Inc. | P21 biomarker assay |
WO2013166448A1 (en) | 2012-05-03 | 2013-11-07 | Amgen Inc. | Stable formulations containing anti-pcsk9 antibodies |
WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
US8586714B2 (en) | 2009-09-01 | 2013-11-19 | Abbvie, Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2013172951A1 (en) | 2012-05-15 | 2013-11-21 | Morphotek, Inc. | Methods for treatment of gastric cancer |
WO2013177386A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Biotherapeutics Inc. | Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy |
WO2013181452A1 (en) | 2012-05-31 | 2013-12-05 | Genentech, Inc. | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
EP2671891A2 (en) | 2008-06-27 | 2013-12-11 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
US8613926B2 (en) | 2011-06-06 | 2013-12-24 | Novo Nordisk A/S | Anti-C5a receptor antibodies |
WO2013192550A2 (en) | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
WO2014001482A1 (en) | 2012-06-29 | 2014-01-03 | Novartis Forschungsstiftung, Zweigniererlassung, Friedrich Miescher Institute For Biomedical Research | Treating diseases by modulating a specific isoform of mkl1 |
WO2014006114A1 (en) | 2012-07-05 | 2014-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
WO2014006115A1 (en) | 2012-07-06 | 2014-01-09 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction |
EP2687232A1 (en) | 2006-12-06 | 2014-01-22 | MedImmune, LLC | Methods of treating systemic lupus erythematosus |
US8642835B2 (en) | 2011-02-25 | 2014-02-04 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US8647622B2 (en) | 2007-08-29 | 2014-02-11 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their use |
US8652469B2 (en) | 2005-07-28 | 2014-02-18 | Novartis Ag | M-CSF-specific monoclonal antibody and uses thereof |
EP2703007A1 (en) | 2007-03-30 | 2014-03-05 | MedImmune, LLC | Antibodies with decreased deamidation profiles |
WO2014036495A2 (en) | 2012-08-31 | 2014-03-06 | Immunogen Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
WO2014039975A2 (en) | 2012-09-10 | 2014-03-13 | Neotope Biosciences Limited | Anti-mcam antibodies and associated methods of use |
US8673305B2 (en) | 2002-01-25 | 2014-03-18 | G2 Therapies Ltd | Methods of treatment with antibodies against the extracellular loops of C5aR |
EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
US8685666B2 (en) | 2007-02-16 | 2014-04-01 | The Board Of Trustees Of Southern Illinois University | ARL-1 specific antibodies and uses thereof |
WO2014055370A1 (en) | 2012-10-01 | 2014-04-10 | Abbvie Biotherapeutics Inc. | Compostions and methods for producing glycoproteins |
US8710191B2 (en) | 2008-08-18 | 2014-04-29 | Pfizer Inc. | Antibodies to CCR2 |
WO2014063205A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
US8716450B2 (en) | 2009-10-15 | 2014-05-06 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US8722855B2 (en) | 2009-10-28 | 2014-05-13 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2014085654A1 (en) | 2012-11-30 | 2014-06-05 | Abbvie Biotherapeutics Inc. | Anti-vegf antibodies and their uses |
EP2740743A2 (en) | 2004-06-01 | 2014-06-11 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
EP2740744A2 (en) | 2007-01-09 | 2014-06-11 | Biogen Idec MA Inc. | SP35 antibodies and uses thereof |
WO2014089416A1 (en) | 2012-12-07 | 2014-06-12 | Sanofi | Compositions comprising anti-cd38 antibodies and lenalidomide |
US8759105B2 (en) | 2000-10-31 | 2014-06-24 | Regeneron Pharmaceuticals, Inc. | Method for genetically modifying mouse embryonic stem cell by homologous recombination |
WO2014100823A1 (en) | 2012-12-21 | 2014-06-26 | Amplimmune, Inc. | Anti-h7cr antibodies |
WO2014100483A1 (en) | 2012-12-19 | 2014-06-26 | Amplimmune, Inc. | Anti-human b7-h4 antibodies and their uses |
US8765918B2 (en) | 1999-03-25 | 2014-07-01 | Abbott Gmbh & Co., Kg | Human antibodies that bind human interleukin-12 |
US8785400B2 (en) | 2006-11-22 | 2014-07-22 | Curedm Group Holdings, Llc | Methods and compositions relating to islet cell neogenesis |
EP2757875A2 (en) | 2011-09-19 | 2014-07-30 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
WO2014114800A1 (en) | 2013-01-25 | 2014-07-31 | Amgen Research (Munich) Gmbh | Antibody constructs for cdh19 and cd3 |
WO2014114801A1 (en) | 2013-01-25 | 2014-07-31 | Amgen Inc. | Antibodies targeting cdh19 for melanoma |
US8816047B2 (en) | 2007-08-30 | 2014-08-26 | Cure DM Group Holdings, LLC | Compositions and methods of using proislet peptides and analogs thereof |
EP2769990A2 (en) | 2004-12-02 | 2014-08-27 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and GLP-1 or PYY |
WO2014130923A2 (en) | 2013-02-25 | 2014-08-28 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
WO2014129895A1 (en) | 2013-02-19 | 2014-08-28 | Stichting Vu-Vumc | Means and method for increasing the sensitivity of cancers for radiotherapy |
US8822645B2 (en) | 2008-07-08 | 2014-09-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
EP2772269A2 (en) | 2009-03-05 | 2014-09-03 | Abbvie Inc. | IL-17 binding proteins |
WO2014140358A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Single chain binding molecules comprising n-terminal abp |
WO2014144763A2 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan Kettering Cancer Center | High affinity anti-gd2 antibodies |
WO2014144553A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Secreted frizzle-related protein 5 (sfrp5) binding proteins and methods of treatment |
WO2014141189A1 (en) | 2013-03-14 | 2014-09-18 | Erasmus University Medical Center | Transgenic non-human mammal for antibody production |
WO2014144960A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Fc variants |
WO2014144632A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Human pac1 antibodies |
WO2014144355A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Anti-gp73 monoclonal antibodies and methods of obtaining the same |
WO2014140368A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Antibody constructs for influenza m2 and cd3 |
WO2014145000A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Anti-cd25 antibodies and their uses |
WO2014144935A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Anti-cd25 antibodies and their uses |
WO2014145254A2 (en) | 2013-03-15 | 2014-09-18 | Sutter West Bay Hospitals | Falz for use as a target for therapies to treat cancer |
WO2014145098A1 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Cell culture compositions with antioxidants and methods for polypeptide production |
US8840898B2 (en) | 2004-08-30 | 2014-09-23 | Biotest Ag | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
WO2014151834A2 (en) | 2013-03-15 | 2014-09-25 | Amgen Inc. | Methods and compositions relating to anti-ccr7 antigen binding proteins |
WO2014153056A2 (en) | 2013-03-14 | 2014-09-25 | Parkash Gill | Cancer treatment using antibodies that bing cell surface grp78 |
US8847005B2 (en) | 2011-10-28 | 2014-09-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
WO2014160490A1 (en) | 2013-03-13 | 2014-10-02 | Genetech, Inc. | Antibody formulations |
WO2014160495A1 (en) | 2013-03-13 | 2014-10-02 | Genentech, Inc. | Formulations with reduced oxidation |
WO2014159764A1 (en) | 2013-03-14 | 2014-10-02 | Amgen Inc. | Chrdl-1 antigen binding proteins and methods of treatment |
WO2014159911A1 (en) | 2013-03-13 | 2014-10-02 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
WO2014160497A1 (en) | 2013-03-13 | 2014-10-02 | Genentech, Inc. | Formulations with reduced oxidation |
US8852608B2 (en) | 2009-02-02 | 2014-10-07 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
WO2014165818A2 (en) | 2013-04-05 | 2014-10-09 | T Cell Therapeutics, Inc. | Compositions and methods for preventing and treating prostate cancer |
WO2014169076A1 (en) | 2013-04-09 | 2014-10-16 | Annexon,,Inc. | Methods of treatment for neuromyelitis optica |
EP2801584A1 (en) | 2007-12-26 | 2014-11-12 | Biotest AG | Agents targeting CD138 and uses thereof |
WO2014190356A2 (en) | 2013-05-24 | 2014-11-27 | Amplimmune, Inc. | Anti-b7-h5 antibodies and their uses |
US8906864B2 (en) | 2005-09-30 | 2014-12-09 | AbbVie Deutschland GmbH & Co. KG | Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use |
EP2810654A1 (en) | 2008-07-08 | 2014-12-10 | AbbVie Inc. | Prostaglandin E2 binding proteins and uses thereof |
WO2014197866A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Modified antibodies and related compounds, compositions, and methods of use |
WO2014197849A2 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Anti-c10orf54 antibodies and uses thereof |
WO2014200349A1 (en) | 2013-06-13 | 2014-12-18 | Fast Forward Pharmaceutical B.V. | Cd40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an tgr5-receptor agonist, an fxr agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis. |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
WO2014209384A1 (en) | 2013-06-28 | 2014-12-31 | Amgen Inc. | Methods for treating homozygous familial hypercholesterolema |
WO2015006504A1 (en) | 2013-07-09 | 2015-01-15 | Annexon, Inc. | Anti-complement factor c1q antibodies and uses thereof |
WO2015010100A2 (en) | 2013-07-18 | 2015-01-22 | Fabrus, Inc. | Humanized antibodies with ultralong complementarity determining regions |
US8945545B2 (en) | 2008-03-18 | 2015-02-03 | Abbvie Inc. | Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23 |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
WO2015017146A2 (en) | 2013-07-18 | 2015-02-05 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
WO2015019286A1 (en) | 2013-08-07 | 2015-02-12 | Friedrich Miescher Institute For Biomedical Research | New screening method for the treatment friedreich's ataxia |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
EP2842968A1 (en) | 2005-04-29 | 2015-03-04 | Janssen Biotech, Inc. | Anti-IL-6 antibodies, compositions, methods and uses |
WO2015031808A2 (en) | 2013-08-30 | 2015-03-05 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
WO2015031782A1 (en) | 2013-08-30 | 2015-03-05 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
US8975029B2 (en) | 2011-05-19 | 2015-03-10 | The Regents Of The University Of Michigan | Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation |
EP2845866A1 (en) | 2006-10-27 | 2015-03-11 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
WO2015035044A2 (en) | 2013-09-04 | 2015-03-12 | Abbvie Biotherapeutics Inc. | Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
US8987418B2 (en) | 2013-03-15 | 2015-03-24 | Abbvie Inc. | Dual specific binding proteins directed against IL-1β and/or IL-17 |
EP2851372A1 (en) | 2007-11-30 | 2015-03-25 | Genentech, Inc. | Anti-VEGF antibodies |
WO2015048520A1 (en) | 2013-09-27 | 2015-04-02 | Genentech, Inc. | Anti-pdl1 antibody formulations |
US9000127B2 (en) | 2012-02-15 | 2015-04-07 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US9006398B2 (en) | 2006-08-04 | 2015-04-14 | Novartis Ag | EPHB3-specific antibody and uses thereof |
WO2015054427A1 (en) | 2013-10-10 | 2015-04-16 | Beth Israel Deaconess Medical Center, Inc. | Tm4sf1 binding proteins and methods of using same |
US9011864B2 (en) | 2007-12-26 | 2015-04-21 | Biotest Ag | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
EP2862579A1 (en) | 2006-10-04 | 2015-04-22 | Dana-Farber Cancer Institute, Inc. | Tumor immunity |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
AU2010292342B2 (en) * | 2009-09-09 | 2015-04-30 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human protease-activated receptor-2 |
WO2015066450A1 (en) | 2013-10-31 | 2015-05-07 | Sanofi | Specific anti-cd38 antibodies for treating human cancers |
US9029508B2 (en) | 2008-04-29 | 2015-05-12 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US9035027B2 (en) | 2008-06-03 | 2015-05-19 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US9040052B1 (en) | 2013-12-17 | 2015-05-26 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
US9045541B2 (en) | 2012-02-06 | 2015-06-02 | Inhibrx Llc | CD47 antibodies and methods of use thereof |
US9045548B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
US9045551B2 (en) | 2012-11-01 | 2015-06-02 | Abbvie Inc. | Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof |
US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US9046513B2 (en) | 2010-08-26 | 2015-06-02 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US9045545B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision medicine by targeting PD-L1 variants for treatment of cancer |
US9051378B1 (en) | 2014-07-15 | 2015-06-09 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
US9051368B2 (en) | 2007-01-16 | 2015-06-09 | Abbvie, Inc. | Methods for treating psoriasis by administering an antibody which binds an epitope of the p40 subunit of IL-12 and/or IL-23 |
WO2015088346A1 (en) | 2013-12-13 | 2015-06-18 | Rijksuniversiteit Groningen | Antibodies against staphylococcus aureus and uses thereof. |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9062111B2 (en) | 2005-12-07 | 2015-06-23 | Medarex, L.L.C. | CTLA-4 antibody dosage escalation regimens |
WO2015095423A2 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
WO2015095418A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
WO2015095410A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
WO2015095539A1 (en) | 2013-12-20 | 2015-06-25 | Genentech, Inc. | Dual specific antibodies |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9068012B1 (en) | 2014-07-15 | 2015-06-30 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
US9067998B1 (en) | 2014-07-15 | 2015-06-30 | Kymab Limited | Targeting PD-1 variants for treatment of cancer |
US9068230B2 (en) | 2007-11-07 | 2015-06-30 | Genentech, Inc. | Methods and compositions for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
WO2015097536A2 (en) | 2013-12-24 | 2015-07-02 | Janssen Pharmaceutical Nv | Anti-vista antibodies and fragments |
EP2893939A1 (en) | 2014-01-10 | 2015-07-15 | Netris Pharma | Anti-netrin-1 antibody |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015109180A2 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
WO2015120075A2 (en) | 2014-02-04 | 2015-08-13 | Genentech, Inc. | Mutant smoothened and methods of using the same |
US9115195B2 (en) | 2010-03-02 | 2015-08-25 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
US9113616B2 (en) | 2011-10-28 | 2015-08-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice having humanized TCR variable genes |
US9120870B2 (en) | 2011-12-30 | 2015-09-01 | Abbvie Inc. | Dual specific binding proteins directed against IL-13 and IL-17 |
EP2918605A1 (en) | 2007-11-12 | 2015-09-16 | U3 Pharma GmbH | Axl antibodies |
EP2918602A1 (en) | 2009-04-16 | 2015-09-16 | AbbVie Biotherapeutics Inc. | Anti-TNF-alpha antibodies and their uses |
EP2921177A2 (en) | 2010-07-09 | 2015-09-23 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2015148736A1 (en) | 2014-03-25 | 2015-10-01 | Genentech, Inc. | Methods of preparing a poloxamer for use in cell culture medium |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
EP2927244A1 (en) | 2008-09-19 | 2015-10-07 | MedImmune, LLC | Antibodies directed to DLL4 and uses thereof |
US9175069B2 (en) | 2009-05-26 | 2015-11-03 | Icahn School Of Medicine At Mount Sinai | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
US9173950B2 (en) | 2012-05-17 | 2015-11-03 | Extend Biosciences, Inc. | Vitamin D-ghrelin conjugates |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015175874A2 (en) | 2014-05-16 | 2015-11-19 | Medimmune, Llc | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
US9193787B2 (en) | 2012-04-20 | 2015-11-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
WO2015179627A1 (en) | 2014-05-21 | 2015-11-26 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer with anti bip or anti mica antibodies |
WO2015184099A1 (en) | 2014-05-28 | 2015-12-03 | 4-Antibody Ag | Anti-gitr antibodies and methods of use thereof |
US9204624B2 (en) | 2013-02-20 | 2015-12-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modifed immunoglobulin heavy chain sequences |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2015189816A1 (en) | 2014-06-13 | 2015-12-17 | Friedrich Miescher Institute For Biomedical Research | New treatment against influenza virus |
WO2015195917A1 (en) | 2014-06-18 | 2015-12-23 | Mersana Therapeutics, Inc. | Monoclonal antibodies against her2 epitope and methods of use thereof |
WO2015198202A1 (en) | 2014-06-23 | 2015-12-30 | Friedrich Miescher Institute For Biomedical Research | Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas |
WO2016001830A1 (en) | 2014-07-01 | 2016-01-07 | Friedrich Miescher Institute For Biomedical Research | Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma |
US9234033B2 (en) | 2012-09-02 | 2016-01-12 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2016007752A1 (en) | 2014-07-09 | 2016-01-14 | Genentech, Inc. | Ph adjustment to improve thaw recovery of cell banks |
WO2016011052A1 (en) | 2014-07-14 | 2016-01-21 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
WO2016011160A1 (en) | 2014-07-15 | 2016-01-21 | Genentech, Inc. | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
WO2016016412A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Antibody constructs for cdh19 and cd3 |
WO2016016859A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody constructs |
WO2016016415A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Bispecific single chain antibody construct with enhanced tissue distribution |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
US9260517B2 (en) | 2009-11-17 | 2016-02-16 | Musc Foundation For Research Development | Human monoclonal antibodies to human nucleolin |
US9259488B2 (en) | 2012-08-17 | 2016-02-16 | The Regents Of The University Of Colorado, A Body Corporate | Anti-C3d antibody conjugates and methods of detecting complement activation |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
WO2016029079A2 (en) | 2014-08-21 | 2016-02-25 | Walter Reed Army Institute Of Research Department Of The Army | Monoclonal antibodies for treatment of microbial infections |
JP2016505257A (en) * | 2012-12-14 | 2016-02-25 | オーエムティー,インコーポレイティド | Polynucleotide encoding rodent antibody having human idiotype and animal containing the same |
US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
WO2016040767A2 (en) | 2014-09-12 | 2016-03-17 | Amgen Inc. | Chrdl-1 epitopes and antibodies |
WO2016044224A1 (en) | 2014-09-15 | 2016-03-24 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
WO2016046768A1 (en) | 2014-09-24 | 2016-03-31 | Friedrich Miescher Institute For Biomedical Research | Lats and breast cancer |
US9308257B2 (en) | 2007-11-28 | 2016-04-12 | Medimmune, Llc | Protein formulation |
US9315583B2 (en) | 2009-10-26 | 2016-04-19 | Genentech, Inc. | Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis |
WO2016061240A1 (en) | 2014-10-15 | 2016-04-21 | Amgen Inc. | Promoter and regulatory elements for improved expression of heterologous genes in host cells |
US9320797B2 (en) | 2007-09-27 | 2016-04-26 | Amgen Inc. | Pharmaceutical formulations |
WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
WO2016069283A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in cart cells and uses thereof |
WO2016070089A2 (en) | 2014-10-31 | 2016-05-06 | Abbvie Biotherapeutics Inc. | Anti-cs1 antibodies and antibody drug conjugates |
WO2016073157A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Anti-ang2 antibodies and methods of use thereof |
WO2016073282A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
WO2016073794A1 (en) | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
WO2016073791A1 (en) | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
WO2016077526A1 (en) | 2014-11-12 | 2016-05-19 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
US9346873B2 (en) | 2008-09-30 | 2016-05-24 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
WO2016081384A1 (en) | 2014-11-17 | 2016-05-26 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
WO2016081808A1 (en) | 2014-11-20 | 2016-05-26 | The Regents Of The University Of California | Compositions and methods related to hematologic recovery |
WO2016081423A1 (en) | 2014-11-18 | 2016-05-26 | Janssen Pharmaceutica Nv | Cd47 antibodies, methods, and uses |
WO2016090300A1 (en) | 2014-12-05 | 2016-06-09 | Genentech, Inc. | Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists |
US9365641B2 (en) | 2012-10-01 | 2016-06-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
US9371366B2 (en) | 2012-12-18 | 2016-06-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
WO2016106221A1 (en) | 2014-12-22 | 2016-06-30 | The Rockefeller University | Anti-mertk agonistic antibodies and uses thereof |
US9383357B2 (en) | 2012-12-07 | 2016-07-05 | Northwestern University | Biomarker for replicative senescence |
WO2016114819A1 (en) | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2016115345A1 (en) | 2015-01-14 | 2016-07-21 | The Brigham And Women's Hospital, | Treatment of cancer with anti-lap monoclonal antibodies |
WO2016118961A1 (en) | 2015-01-24 | 2016-07-28 | Academia Sinica | Cancer markers and methods of use thereof |
US9403855B2 (en) | 2010-05-10 | 2016-08-02 | Academia Sinica | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
WO2016123329A2 (en) | 2015-01-28 | 2016-08-04 | Genentech, Inc. | Gene expression markers and treatment of multiple sclerosis |
WO2016123593A1 (en) | 2015-01-30 | 2016-08-04 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
WO2016126972A1 (en) | 2015-02-04 | 2016-08-11 | Genentech, Inc. | Mutant smoothened and methods of using the same |
WO2016130539A2 (en) | 2015-02-09 | 2016-08-18 | Memorial Sloan Kettering Cancer Center | Multi-specific antibodies with affinity for human a33 antigen and dota metal complex and uses thereof |
WO2016137985A1 (en) | 2015-02-26 | 2016-09-01 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
US9434782B2 (en) | 2009-07-08 | 2016-09-06 | Kymab Limited | Animal models and therapeutic molecules |
WO2016139482A1 (en) | 2015-03-03 | 2016-09-09 | Kymab Limited | Antibodies, uses & methods |
WO2016141111A1 (en) | 2015-03-03 | 2016-09-09 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
US9441035B2 (en) | 2013-03-15 | 2016-09-13 | Genentech, Inc. | Cell culture media and methods of antibody production |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
WO2016149368A1 (en) | 2015-03-17 | 2016-09-22 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
US9452219B2 (en) | 2011-06-02 | 2016-09-27 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles |
EP3073267A1 (en) | 2004-09-21 | 2016-09-28 | Medimmune, Inc. | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
EP3072525A1 (en) | 2007-05-14 | 2016-09-28 | MedImmune, LLC | Methods of reducing basophil levels |
WO2016151558A1 (en) | 2015-03-25 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of factor d of the alternative complement pathway |
WO2016151557A1 (en) | 2015-03-25 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of c5 convertase of the alternative complement pathway |
KR20160116056A (en) | 2008-08-14 | 2016-10-06 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | Anti-il-12/il-23 antibodies |
WO2016161410A2 (en) | 2015-04-03 | 2016-10-06 | Xoma Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
WO2016161446A1 (en) * | 2015-04-03 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
US9464139B2 (en) | 2013-08-30 | 2016-10-11 | Amgen Inc. | GITR antigen binding proteins and methods of use thereof |
WO2016166360A1 (en) | 2015-04-17 | 2016-10-20 | Bayer Pharma Aktiengesellschaft | Bispecific antibody constructs for cdh3 and cd3 |
WO2016171742A1 (en) | 2015-04-24 | 2016-10-27 | Amgen Inc. | Methods for treating or preventing migraine headache |
EP3091029A1 (en) | 2011-10-31 | 2016-11-09 | F. Hoffmann-La Roche AG | Anti-il13 antibody formulations |
WO2016179517A1 (en) | 2015-05-07 | 2016-11-10 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9499628B2 (en) | 2013-06-14 | 2016-11-22 | Children's Hospital Medical Center | Method of boosting the immune response in neonates |
EP3098238A1 (en) | 2005-11-25 | 2016-11-30 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
WO2016191397A1 (en) | 2015-05-22 | 2016-12-01 | Td2 Inc. | Benzamide and active compound compositions and methods of use |
WO2016196237A1 (en) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
WO2016196298A1 (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Therapeutic and diagnolstic methods for cancer |
WO2016191811A1 (en) | 2015-06-03 | 2016-12-08 | The University Of Queensland | Mobilizing agents and uses therefor |
US9516868B2 (en) | 2010-08-02 | 2016-12-13 | Regeneron Pharmaceuticals, Inc. | Mice that make VL binding proteins |
WO2016201388A2 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
WO2016201389A2 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
WO2016205320A1 (en) | 2015-06-17 | 2016-12-22 | Genentech, Inc. | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes |
WO2016207717A1 (en) | 2015-06-24 | 2016-12-29 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments |
WO2017004091A1 (en) | 2015-06-29 | 2017-01-05 | Genentech, Inc. | Type ii anti-cd20 antibody for use in organ transplantation |
US9547009B2 (en) | 2012-08-21 | 2017-01-17 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US9550826B2 (en) | 2013-11-15 | 2017-01-24 | Abbvie Inc. | Glycoengineered binding protein compositions |
EP3124045A2 (en) | 2006-12-20 | 2017-02-01 | Xoma (Us) Llc | Treatment of il-1 beta related diseases |
US9562097B2 (en) | 2011-07-01 | 2017-02-07 | Genentech, Inc. | Use of anti-CD83 agonist antibodies for treating autoimmune diseases |
WO2017021356A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs binding mesothelin and cd3 |
WO2017021349A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs binding dll3 and cd3 |
WO2017021354A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Antibody constructs for cd70 and cd3 |
WO2017021362A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Antibody constructs for flt3 and cd3 |
WO2017021370A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs binding egfrviii and cd3 |
WO2017031353A1 (en) | 2015-08-19 | 2017-02-23 | Rutgers, The State University Of New Jersey | Novel methods of generating antibodies |
US9585374B2 (en) | 2004-10-22 | 2017-03-07 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
WO2017040301A1 (en) | 2015-08-28 | 2017-03-09 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
WO2017040790A1 (en) | 2015-09-01 | 2017-03-09 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
WO2017049004A1 (en) | 2015-09-15 | 2017-03-23 | Amgen Inc. | Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof |
WO2017058780A1 (en) | 2015-09-30 | 2017-04-06 | Merck Patent Gmbh | Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US9617334B2 (en) | 2012-06-06 | 2017-04-11 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
US9617600B2 (en) | 2009-04-18 | 2017-04-11 | Genentech, Inc. | Methods for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
US9615550B2 (en) | 2011-10-28 | 2017-04-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
WO2017062672A2 (en) | 2015-10-06 | 2017-04-13 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
US9622459B2 (en) | 2011-12-20 | 2017-04-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
WO2017072669A1 (en) | 2015-10-28 | 2017-05-04 | Friedrich Miescher Institute For Biomedical Research | Tenascin-w and biliary tract cancers |
WO2017075432A2 (en) | 2015-10-29 | 2017-05-04 | Alector Llc | Anti-siglec-9 antibodies and methods of use thereof |
WO2017076864A1 (en) | 2015-11-02 | 2017-05-11 | Netris Pharma | Combination therapy of ntn1 neutralizing agent with drugs inhibiting epigenetic control |
WO2017076492A1 (en) | 2015-11-03 | 2017-05-11 | Merck Patent Gmbh | Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof |
WO2017083582A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
US9663568B2 (en) | 2012-02-15 | 2017-05-30 | Novo Nordisk A/S | Antibodies that bind peptidoglycan recognition protein 1 |
WO2017091745A1 (en) | 2015-11-25 | 2017-06-01 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
US9670276B2 (en) | 2012-07-12 | 2017-06-06 | Abbvie Inc. | IL-1 binding proteins |
WO2017095808A1 (en) | 2015-11-30 | 2017-06-08 | Abbvie Inc. | ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
WO2017095805A1 (en) | 2015-11-30 | 2017-06-08 | Abbvie Inc. | ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
WO2017106578A1 (en) | 2015-12-15 | 2017-06-22 | Amgen Inc. | Pacap antibodies and uses thereof |
EP3184544A1 (en) | 2015-12-23 | 2017-06-28 | Julius-Maximilians-Universität Würzburg | Glycoprotein v inhibitors for use as coagulants |
WO2017117304A1 (en) | 2015-12-30 | 2017-07-06 | Genentech, Inc. | Use of tryptophan derivatives for protein formulations |
WO2017117311A1 (en) | 2015-12-30 | 2017-07-06 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
WO2017136558A1 (en) | 2016-02-04 | 2017-08-10 | Curis, Inc. | Mutant smoothened and methods of using the same |
WO2017137830A1 (en) | 2016-02-12 | 2017-08-17 | Janssen Pharmaceutica Nv | Anti-vista (b7h5) antibodies |
US9738701B2 (en) | 2003-05-30 | 2017-08-22 | Merus N.V. | Method for selecting a single cell expressing a heterogeneous combination of antibodies |
EP3211094A2 (en) | 2009-09-03 | 2017-08-30 | F. Hoffmann-La Roche AG | Methods for treating, diagnosing, and monitoring rheumatoid arthritis |
WO2017151502A1 (en) | 2016-02-29 | 2017-09-08 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
US9759726B2 (en) | 2014-03-27 | 2017-09-12 | Academia Sinica | Reactive labelling compounds and uses thereof |
US9758576B2 (en) | 2013-05-06 | 2017-09-12 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
US9765156B2 (en) | 2012-07-13 | 2017-09-19 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
US9765133B2 (en) | 2008-06-27 | 2017-09-19 | Merus N.V. | Antibody producing non-human mammals |
EP3219727A1 (en) | 2016-03-17 | 2017-09-20 | Tillotts Pharma AG | Anti-tnf alpha-antibodies and functional fragments thereof |
EP3219726A1 (en) | 2016-03-17 | 2017-09-20 | Tillotts Pharma AG | Anti-tnf alpha-antibodies and functional fragments thereof |
WO2017158079A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnfalpha-antibodies and functional fragments thereof |
WO2017160754A1 (en) | 2016-03-15 | 2017-09-21 | Mersana Therapeutics,Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
WO2017158101A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF |
WO2017159699A1 (en) | 2016-03-15 | 2017-09-21 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
WO2017158084A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF |
WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
WO2017172771A2 (en) | 2016-03-29 | 2017-10-05 | Janssen Biotech, Inc. | Method of treating psoriasis with increased interval dosing of anti-il12/23 antibody |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
WO2017175058A1 (en) | 2016-04-07 | 2017-10-12 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
US9790267B2 (en) | 2011-11-08 | 2017-10-17 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
US9790478B2 (en) | 2013-03-14 | 2017-10-17 | Abbott Laboratories | HCV NS3 recombinant antigens and mutants thereof for improved antibody detection |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
WO2017181079A2 (en) | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
WO2017181111A2 (en) | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US9796780B2 (en) | 2012-05-14 | 2017-10-24 | Biogen Ma Inc. | LINGO-2 antagonists for treatment of conditions involving motor neurons |
WO2017185089A2 (en) | 2016-04-22 | 2017-10-26 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
WO2017182427A1 (en) | 2016-04-19 | 2017-10-26 | Amgen Research (Munich) Gmbh | Administration of a bispecific construct binding to cd33 and cd3 for use in a method for the treatment of myeloid leukemia |
US9816981B2 (en) | 2007-03-23 | 2017-11-14 | Academia Sinica | Alkynyl sugar analogs for labeling and visualization of glycoconjugates in cells |
US9815890B2 (en) | 2010-06-22 | 2017-11-14 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3d fragment of complement component 3 |
WO2017196902A2 (en) | 2016-05-10 | 2017-11-16 | Genentech, Inc. | Methods of decreasing trisulfide bonds during recombinant production of polypeptides |
WO2017197153A1 (en) | 2016-05-11 | 2017-11-16 | Huya Bioscien International, Llc | Combination therapies of hdac inhibitors pd-1 inhibitors |
WO2017194568A1 (en) | 2016-05-11 | 2017-11-16 | Sanofi | Treatment regimen using anti-muc1 maytansinoid immunoconjugate antibody for the treatment of tumors |
US9822148B2 (en) | 2012-06-25 | 2017-11-21 | Hoya Corporation | EGFR-binding peptide |
WO2017201204A1 (en) | 2016-05-17 | 2017-11-23 | Abbvie Biotherapeutics Inc. | ANTI-cMet ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
WO2017202744A1 (en) | 2016-05-26 | 2017-11-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
WO2017205742A1 (en) | 2016-05-27 | 2017-11-30 | Abbvie Biotherapeutics Inc. | Anti-cd40 antibodies and their uses |
WO2017205745A1 (en) | 2016-05-27 | 2017-11-30 | Abbvie Biotherapeutics Inc. | Anti-4-1bb antibodies and their uses |
WO2017205721A1 (en) | 2016-05-27 | 2017-11-30 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
US9834610B2 (en) | 2013-01-31 | 2017-12-05 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector T cells |
US9841427B2 (en) | 2013-03-14 | 2017-12-12 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
US9840554B2 (en) | 2015-06-15 | 2017-12-12 | Abbvie Inc. | Antibodies against platelet-derived growth factor (PDGF) |
WO2017215590A1 (en) | 2016-06-13 | 2017-12-21 | I-Mab | Anti-pd-l1 antibodies and uses thereof |
US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
WO2018007999A1 (en) | 2016-07-08 | 2018-01-11 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
WO2018018011A2 (en) | 2016-07-22 | 2018-01-25 | Amgen Inc. | Methods of purifying fc-containing proteins |
US9879042B2 (en) | 2014-09-08 | 2018-01-30 | Academia Sinica | Human iNKT cell activation using glycolipids |
US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
WO2018020476A1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings, Europe B.V. | Anti-pd-1 antibodies |
EP3279215A1 (en) | 2009-11-24 | 2018-02-07 | MedImmune Limited | Targeted binding agents against b7-h1 |
WO2018026748A1 (en) | 2016-08-01 | 2018-02-08 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof |
WO2018025178A1 (en) | 2016-08-02 | 2018-02-08 | Aduro Biotech Holdings, Europe B.V. | Antibodies against human ctla-4 |
WO2018029124A1 (en) | 2016-08-08 | 2018-02-15 | F. Hoffmann-La Roche Ag | Therapeutic and diagnostic methods for cancer |
WO2018031865A1 (en) | 2016-08-12 | 2018-02-15 | Genentech, Inc. | Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a vegf inhibitor |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
US9914956B2 (en) | 2012-08-18 | 2018-03-13 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
EP2516457B1 (en) | 2009-12-21 | 2018-03-14 | Regeneron Pharmaceuticals, Inc. | Humanized fc gamma r mice |
WO2018049248A1 (en) | 2016-09-09 | 2018-03-15 | Icellhealth Consulting Llc | Oncolytic virus equipped with bispecific engager molecules |
WO2018053106A1 (en) | 2016-09-14 | 2018-03-22 | Abbvie Biotherapeutics Inc. | Anti-pd-1(cd279) antibodies |
WO2018050111A1 (en) | 2016-09-19 | 2018-03-22 | I-Mab | Anti-gm-csf antibodies and uses thereof |
WO2018057669A1 (en) | 2016-09-21 | 2018-03-29 | Alexo Therapeutics Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
WO2018057735A1 (en) | 2016-09-21 | 2018-03-29 | Nextcure, Inc. | Antibodies for siglec-15 and methods of use thereof |
US9932398B2 (en) | 2011-10-17 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
WO2018064436A1 (en) | 2016-09-30 | 2018-04-05 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il23 specific antibody |
WO2018064255A2 (en) | 2016-09-28 | 2018-04-05 | Xoma (Us) Llc | Antibodies that bind interleukin-2 and uses thereof |
WO2018064299A1 (en) | 2016-09-29 | 2018-04-05 | Genentech, Inc. | Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a taxane |
WO2018067468A1 (en) | 2016-10-03 | 2018-04-12 | Abbott Laboratories | Improved methods of assessing uch-l1 status in patient samples |
WO2018068028A1 (en) | 2016-10-06 | 2018-04-12 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
US9951125B2 (en) | 2006-11-30 | 2018-04-24 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
EP3311846A1 (en) | 2014-09-02 | 2018-04-25 | ImmunoGen, Inc. | Methods for formulating antibody drug conjugate compositions |
WO2018081578A1 (en) | 2016-10-28 | 2018-05-03 | Astute Medical, Inc. | Use of antibodies to timp-2 for the improvement of renal function |
WO2018081531A2 (en) | 2016-10-28 | 2018-05-03 | Ariad Pharmaceuticals, Inc. | Methods for human t-cell activation |
US9963716B2 (en) | 2011-09-26 | 2018-05-08 | Kymab Limited | Chimaeric surrogate light chains (SLC) comprising human VpreB |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
WO2018083538A1 (en) | 2016-11-07 | 2018-05-11 | Neuracle Scienc3 Co., Ltd. | Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof |
WO2018085359A1 (en) | 2016-11-02 | 2018-05-11 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and parp inhibitors |
US9969814B2 (en) | 2010-02-08 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | Methods for making fully human bispecific antibodies using a common light chain |
WO2018087285A1 (en) | 2016-11-10 | 2018-05-17 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Or10h1 antigen binding proteins and uses thereof |
WO2018090052A1 (en) | 2016-11-14 | 2018-05-17 | Amgen Inc. | Bispecific or biparatopic antigen binding proteins and uses thereof |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US9975957B2 (en) | 2014-03-31 | 2018-05-22 | Genentech, Inc. | Anti-OX40 antibodies and methods of use |
EP3323830A1 (en) | 2010-06-19 | 2018-05-23 | Memorial Sloan-Kettering Cancer Center | Anti-gd2 antibodies |
WO2018093841A1 (en) | 2016-11-16 | 2018-05-24 | Janssen Biotech, Inc. | Method of treating psoriasis with anti-il-23 specific antibody |
US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
WO2018098401A1 (en) | 2016-11-23 | 2018-05-31 | Translational Drug Development, Llc | Benzamide and active compound compositions and methods of use |
US9989540B2 (en) | 2013-05-10 | 2018-06-05 | The Regents Of The University Of California | Diagnostic and monitoring system for Huntington's disease |
WO2018106864A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
WO2018106862A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
WO2018112346A1 (en) | 2016-12-15 | 2018-06-21 | Abbvie Biotherapeutics Inc. | Anti-ox40 antibodies and their uses |
US10005835B2 (en) | 2013-04-29 | 2018-06-26 | Sanofi | Anti-IL-4/anti-IL-13 bispecific antibody formulations |
US10005847B2 (en) | 2014-05-27 | 2018-06-26 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
EP3339445A1 (en) | 2006-09-08 | 2018-06-27 | AbbVie Bahamas Ltd. | Interleukin -13 binding proteins |
WO2018122043A1 (en) | 2016-12-27 | 2018-07-05 | F. Hoffmann-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
WO2018122205A2 (en) | 2016-12-27 | 2018-07-05 | F. Hoffmann-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
WO2018122204A1 (en) | 2016-12-27 | 2018-07-05 | F. Hoffmann-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
WO2018127570A1 (en) | 2017-01-05 | 2018-07-12 | Netris Pharma | Combined treatment with netrin-1 interfering drug and immune checkpoint inhibitors drugs |
US10023892B2 (en) | 2014-05-27 | 2018-07-17 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
WO2018137598A1 (en) | 2017-01-24 | 2018-08-02 | I-Mab | Anti-cd73 antibodies and uses thereof |
WO2018140026A1 (en) | 2017-01-27 | 2018-08-02 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
WO2018141910A1 (en) | 2017-02-02 | 2018-08-09 | Amgen Research (Munich) Gmbh | Low ph pharmaceutical composition comprising t cell engaging antibody constructs |
WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
EP3360567A1 (en) | 2007-11-07 | 2018-08-15 | Genentech, Inc. | Amp for use in treating microbial disorders |
WO2018153320A1 (en) | 2017-02-21 | 2018-08-30 | 上海君实生物医药科技股份有限公司 | Anti-pd-l1 antibody and application thereof |
WO2018160841A1 (en) | 2017-03-01 | 2018-09-07 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
US10077304B2 (en) | 2013-08-14 | 2018-09-18 | The Governing Council Of The University Of Toronto | Antibodies against frizzled receptor |
US10080790B2 (en) | 2014-09-19 | 2018-09-25 | The Regents Of The University Of Michigan | Staphylococcus aureus materials and methods |
WO2018175942A1 (en) | 2017-03-23 | 2018-09-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
WO2018172465A1 (en) | 2017-03-22 | 2018-09-27 | Sanofi | Treatment of lupus using humanized anti-cxcr5 antibodies |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
US10087255B2 (en) | 2015-04-07 | 2018-10-02 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
EP3381445A2 (en) | 2007-11-15 | 2018-10-03 | Amgen Inc. | Aqueous formulation of antibody stablised by antioxidants for parenteral administration |
WO2018178364A1 (en) | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for treating lung cancer |
WO2018178040A1 (en) | 2017-03-30 | 2018-10-04 | Merck Patent Gmbh | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
WO2018178352A1 (en) | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting prostate cancer |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
EP3385280A1 (en) | 2011-06-10 | 2018-10-10 | MedImmune Limited | Anti-pseudomonas psl binding molecules and uses thereof |
WO2018191531A1 (en) | 2017-04-15 | 2018-10-18 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
WO2018191502A2 (en) | 2017-04-13 | 2018-10-18 | Agenus Inc. | Anti-cd137 antibodies and methods of use thereof |
US10106611B2 (en) | 2013-12-06 | 2018-10-23 | Dana-Farber Cancer Institute, Inc. | Antibodies that bind to MHC class I polypeptide-related sequence A |
WO2018195527A1 (en) | 2017-04-22 | 2018-10-25 | Immunomic Therapeutics, Inc. | Improved lamp constructs |
WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
WO2018200823A1 (en) | 2017-04-28 | 2018-11-01 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
WO2018196782A1 (en) | 2017-04-27 | 2018-11-01 | The University Of Hong Kong | Use of hcn inhibitors for treatment of cancer |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
WO2018204363A1 (en) | 2017-05-01 | 2018-11-08 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
WO2018204907A1 (en) | 2017-05-05 | 2018-11-08 | Amgen Inc. | Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration |
WO2018204534A1 (en) | 2017-05-02 | 2018-11-08 | Immunomic Therapeutics, Inc. | Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens |
WO2018209194A2 (en) | 2017-05-12 | 2018-11-15 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
US10131695B2 (en) | 2011-09-20 | 2018-11-20 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
US10130081B2 (en) | 2011-08-05 | 2018-11-20 | Regeneron Pharmaceuticals, Inc. | Humanized universal light chain mice |
WO2018213316A1 (en) | 2017-05-16 | 2018-11-22 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
WO2018218169A1 (en) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
WO2018222685A1 (en) | 2017-05-31 | 2018-12-06 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1 |
WO2018222783A1 (en) | 2017-05-30 | 2018-12-06 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers |
WO2018222689A1 (en) | 2017-05-31 | 2018-12-06 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
WO2018222770A1 (en) | 2017-05-31 | 2018-12-06 | Amgen Inc. | Anti-jagged1 antigen binding proteins |
US10149461B2 (en) | 2008-10-27 | 2018-12-11 | Revivicor, Inc. | Immunocompromised ungulates |
US10149462B2 (en) | 2013-10-01 | 2018-12-11 | Kymab Limited | Animal models and therapeutic molecules |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2018226671A1 (en) | 2017-06-06 | 2018-12-13 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands |
US10154658B2 (en) | 2013-02-22 | 2018-12-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
WO2018237097A1 (en) | 2017-06-20 | 2018-12-27 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
WO2019014572A1 (en) | 2017-07-14 | 2019-01-17 | Pfizer, Inc. | Antibodies to madcam |
US10183988B2 (en) | 2013-06-07 | 2019-01-22 | Duke University | Anti-Complement factor H antibodies |
WO2019018757A1 (en) | 2017-07-21 | 2019-01-24 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2019023460A1 (en) | 2017-07-27 | 2019-01-31 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
US10197573B2 (en) | 2013-03-14 | 2019-02-05 | Abbott Laboratories | HCV core lipid binding domain monoclonal antibodies |
WO2019028283A1 (en) | 2017-08-03 | 2019-02-07 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
WO2019028292A1 (en) | 2017-08-03 | 2019-02-07 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
WO2019028382A1 (en) | 2017-08-04 | 2019-02-07 | Amgen Inc. | Method of conjugation of cys-mabs |
US10208109B2 (en) | 2005-11-30 | 2019-02-19 | Abbvie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
EP3447075A2 (en) | 2015-05-15 | 2019-02-27 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
WO2019051164A1 (en) | 2017-09-07 | 2019-03-14 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
EP3456743A1 (en) | 2013-05-30 | 2019-03-20 | Kiniksa Pharmaceuticals, Ltd. | Oncostatin m receptor antigen binding proteins |
US10238093B2 (en) | 2012-06-12 | 2019-03-26 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
WO2019057816A1 (en) | 2017-09-22 | 2019-03-28 | F. Hoffmann-La Roche Ag | Multivalent mono- or bispecific recombinant antibodies for analytic purpose |
WO2019059411A1 (en) | 2017-09-20 | 2019-03-28 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent |
WO2019058345A2 (en) | 2017-09-25 | 2019-03-28 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
US10253101B2 (en) | 2015-08-06 | 2019-04-09 | Xoma (Us) Llc | Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | Anti-lap antibodies and uses thereof |
US10274488B2 (en) | 2008-07-15 | 2019-04-30 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
WO2019083904A1 (en) | 2017-10-23 | 2019-05-02 | Chan Zuckerberg Biohub, Inc. | Measurement of afucosylated igg fc glycans and related treatment methods |
WO2019084460A1 (en) | 2017-10-26 | 2019-05-02 | The Regents Of The University Of California | Inhibition of oxidation-specific epitopes to treat ischemic reperfusion injury |
US10279021B2 (en) | 2014-03-14 | 2019-05-07 | Dana-Faber Cancer Institute, Inc. | Vaccine compositions and methods for restoring NKG2D pathway function against cancers |
EP3479844A1 (en) | 2005-04-15 | 2019-05-08 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
WO2019087115A1 (en) | 2017-10-31 | 2019-05-09 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
WO2019090263A1 (en) | 2017-11-06 | 2019-05-09 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
WO2019089594A1 (en) | 2017-10-31 | 2019-05-09 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and cytarabine |
US10294303B2 (en) | 2015-12-23 | 2019-05-21 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists |
US10301391B2 (en) | 2016-02-03 | 2019-05-28 | Amgen Research (Munich) Gmbh | BCMA and CD3 bispecific T cell engaging antibody constructs |
WO2019102435A1 (en) | 2017-11-27 | 2019-05-31 | Euro-Celtique S.A. | Humanized antibodies targeting human tissue factor |
US10314296B2 (en) | 2013-02-22 | 2019-06-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
WO2019110662A1 (en) | 2017-12-05 | 2019-06-13 | Progastrine Et Cancers S.À R.L. | Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer |
WO2019112860A1 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
WO2019113525A2 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1) |
WO2019113375A2 (en) | 2017-12-06 | 2019-06-13 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
EP3498735A1 (en) | 2006-10-19 | 2019-06-19 | Sanofi | Novel anti-cd38 antibodies for the treatment of leukemia |
WO2019118426A1 (en) | 2017-12-11 | 2019-06-20 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
WO2019120232A1 (en) | 2017-12-20 | 2019-06-27 | Harbour Biomed (Shanghai) Co., Ltd | Antibodies binding ctla-4 and uses thereof |
US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
US10336784B2 (en) | 2016-03-08 | 2019-07-02 | Academia Sinica | Methods for modular synthesis of N-glycans and arrays thereof |
WO2019129211A1 (en) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Antibodies and variants thereof against pd-l1 |
WO2019133961A1 (en) | 2017-12-29 | 2019-07-04 | Amgen Inc. | Bispecific antibody construct directed to muc17 and cd3 |
US10342858B2 (en) | 2015-01-24 | 2019-07-09 | Academia Sinica | Glycan conjugates and methods of use thereof |
US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
EP3508499A1 (en) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
WO2019140216A1 (en) | 2018-01-12 | 2019-07-18 | Amgen Inc. | Pac1 antibodies and uses thereof |
US10358500B2 (en) | 2014-04-04 | 2019-07-23 | Bionomics Inc. | Humanized antibodies that bind LGR5 |
WO2019145537A1 (en) | 2018-01-26 | 2019-08-01 | Ecs-Progastrin Sa | Combination of progastrin detection with other cancer biomarkers in cancer diagnosis |
EP3524626A1 (en) | 2007-03-22 | 2019-08-14 | Biogen MA Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
EP3524620A1 (en) | 2008-10-14 | 2019-08-14 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
WO2019165434A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2019168403A2 (en) | 2018-03-02 | 2019-09-06 | Labo Bio-Medical Investments B.V. | Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders |
WO2019169229A1 (en) | 2018-03-01 | 2019-09-06 | Nextcure, Inc. | Klrg1 binding compositions and methods of use thereof |
WO2019166499A1 (en) | 2018-02-27 | 2019-09-06 | Ecs-Progastrin Sa | Progastrin as a biomarker for immunotherapy |
WO2019171252A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
US10421824B2 (en) | 2013-03-13 | 2019-09-24 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
US10421823B2 (en) | 2013-03-13 | 2019-09-24 | Amgen Inc. | Proteins specific for BAFF and B7RP1 and uses thereof |
US10435467B2 (en) | 2015-01-08 | 2019-10-08 | Biogen Ma Inc. | LINGO-1 antagonists and uses for treatment of demyelinating disorders |
WO2019197651A1 (en) | 2018-04-12 | 2019-10-17 | Mediapharma S.R.L. | Lgals3bp antibody-drug-conjugate and its use for the treatment of cancer |
EP3556863A1 (en) | 2013-11-06 | 2019-10-23 | Astute Medical, Inc. | Assays for igfbp7 having improved performance in biological samples |
US10457744B2 (en) | 2013-08-07 | 2019-10-29 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
WO2019207159A1 (en) | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
US10465007B2 (en) | 2017-01-20 | 2019-11-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-PD-1 antibodies and uses thereof |
WO2019211489A1 (en) | 2018-05-04 | 2019-11-07 | Merck Patent Gmbh | COMBINED INHIBITION OF PD-1/PD-L1, TGFβ AND DNA-PK FOR THE TREATMENT OF CANCER |
WO2019215701A1 (en) | 2018-05-11 | 2019-11-14 | Janssen Biotech, Inc. | Methods of treating depression using il-23 antibodies |
WO2019222281A1 (en) | 2018-05-15 | 2019-11-21 | Immunomic Therapeutics, Inc | Improved lamp constructs comprising allergens |
WO2019222130A1 (en) | 2018-05-15 | 2019-11-21 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and flt3 inhibitors |
WO2019226973A1 (en) | 2018-05-25 | 2019-11-28 | Alector Llc | Anti-sirpa antibodies and methods of use thereof |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
US10494445B2 (en) | 2010-03-31 | 2019-12-03 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
EP3575794A1 (en) | 2012-02-10 | 2019-12-04 | Seattle Genetics, Inc. | Detection and treatment of cd30+ cancers |
EP3574919A1 (en) | 2011-07-13 | 2019-12-04 | AbbVie Inc. | Methods and compositions for treating asthma using anti-il-13 antibodies |
WO2019236965A1 (en) | 2018-06-08 | 2019-12-12 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
WO2019246557A1 (en) | 2018-06-23 | 2019-12-26 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor |
US10525130B2 (en) | 2012-03-26 | 2020-01-07 | Sanofi | Stable IGG4 based binding agent formulations |
EP3590539A1 (en) | 2014-03-04 | 2020-01-08 | Kymab Limited | Antibodies, uses & methods |
US10538592B2 (en) | 2016-08-22 | 2020-01-21 | Cho Pharma, Inc. | Antibodies, binding fragments, and methods of use |
WO2020016459A1 (en) | 2018-07-20 | 2020-01-23 | Pierre Fabre Medicament | Receptor for vista |
WO2020018789A1 (en) | 2018-07-18 | 2020-01-23 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent |
WO2020016838A2 (en) | 2018-07-18 | 2020-01-23 | Janssen Biotech, Inc. | Sustained response predictors after treatment with anti-il23 specific antibody |
WO2020023920A1 (en) | 2018-07-27 | 2020-01-30 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
WO2020025532A1 (en) | 2018-07-30 | 2020-02-06 | Amgen Research (Munich) Gmbh | Prolonged administration of a bispecific antibody construct binding to cd33 and cd3 |
WO2020025792A1 (en) | 2018-08-03 | 2020-02-06 | Amgen Research (Munich) Gmbh | Antibody constructs for cldn18.2 and cd3 |
WO2020033485A1 (en) | 2018-08-08 | 2020-02-13 | Genentech, Inc. | Use of tryptophan derivatives and l-methionine for protein formulation |
WO2020043670A1 (en) | 2018-08-27 | 2020-03-05 | Affimed Gmbh | Cryopreserved nk cells preloaded with an antibody construct |
EP3626744A1 (en) | 2015-05-29 | 2020-03-25 | AbbVie Inc. | Anti-cd40 antibodies and uses thereof |
WO2020061060A1 (en) | 2018-09-19 | 2020-03-26 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
WO2020061349A1 (en) | 2018-09-21 | 2020-03-26 | Genentech, Inc. | Diagnostic methods for triple-negative breast cancer |
WO2020065532A1 (en) | 2018-09-24 | 2020-04-02 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
WO2020064971A1 (en) | 2018-09-26 | 2020-04-02 | Merck Patent Gmbh | Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer |
WO2020070678A2 (en) | 2018-10-03 | 2020-04-09 | Staten Biotechnology B.V. | Antibodies specific for human and cynomolgus apoc3 and methods of use thereof |
US10618955B2 (en) | 2014-07-15 | 2020-04-14 | Kymab Limited | Methods for treating neurodegenerative disease using anti-PD-1 antibodies |
WO2020076969A2 (en) | 2018-10-10 | 2020-04-16 | Tilos Therapeutics, Inc. | Anti-lap antibody variants and uses thereof |
WO2020077212A1 (en) | 2018-10-11 | 2020-04-16 | Amgen Inc. | Downstream processing of bispecific antibody constructs |
WO2020081767A1 (en) | 2018-10-18 | 2020-04-23 | Genentech, Inc. | Diagnostic and therapeutic methods for sarcomatoid kidney cancer |
WO2020078905A1 (en) | 2018-10-15 | 2020-04-23 | Merck Patent Gmbh | Combination therapy utilizing dna alkylating agents and atr inhibitors |
WO2020092455A2 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
WO2020096959A1 (en) | 2018-11-05 | 2020-05-14 | Genentech, Inc. | Methods of producing two chain proteins in prokaryotic host cells |
US10656156B2 (en) | 2012-07-05 | 2020-05-19 | Mepur Ravindranath | Diagnostic and therapeutic potential of HLA-E monospecific monoclonal IgG antibodies directed against tumor cell surface and soluble HLA-E |
US10653779B2 (en) | 2013-03-13 | 2020-05-19 | Genentech, Inc. | Formulations with reduced oxidation |
WO2020099533A1 (en) | 2018-11-16 | 2020-05-22 | F. Hoffmann-La Roche Ag | Streptavidin-coated solid phases with a member of a binding pair |
WO2020104943A2 (en) | 2018-11-20 | 2020-05-28 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il-23 specific antibody |
US10667501B2 (en) | 2012-05-17 | 2020-06-02 | Kymab Limited | Transgenic non-human vertebrate for the in vivo production of dual specificity immunoglobulins or hypermutated heavy chain only immunoglobulins |
WO2020118293A2 (en) | 2018-12-07 | 2020-06-11 | Georgia Tech Research Corporation | Antibodies that bind to natively folded myocilin |
WO2020118011A1 (en) | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
WO2020128864A1 (en) | 2018-12-18 | 2020-06-25 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
US10703813B2 (en) | 2014-12-19 | 2020-07-07 | Universite De Nantes | Anti IL-34 antibodies |
WO2020150152A1 (en) | 2019-01-14 | 2020-07-23 | Genentech, Inc. | Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine |
WO2020148651A1 (en) | 2019-01-15 | 2020-07-23 | Janssen Biotech, Inc. | Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis |
WO2020154410A1 (en) | 2019-01-23 | 2020-07-30 | Genentech, Inc. | Methods of producing multimeric proteins in eukaryotic host cells |
WO2020152544A1 (en) | 2019-01-23 | 2020-07-30 | Janssen Biotech, Inc. | Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis |
WO2020159504A1 (en) | 2019-01-30 | 2020-08-06 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
EP3693395A1 (en) | 2012-05-18 | 2020-08-12 | Amgen Inc. | St2 antigen binding proteins |
WO2020163589A1 (en) | 2019-02-08 | 2020-08-13 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
US10745487B2 (en) | 2016-03-22 | 2020-08-18 | Bionomics Limited | Method of treating cancer by administering an anti-LGR5 monoclonal antibody |
US10745483B2 (en) | 2013-03-15 | 2020-08-18 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
EP3698807A1 (en) | 2005-01-21 | 2020-08-26 | Genentech, Inc. | Fixed dosing of her antibodies |
WO2020168555A1 (en) | 2019-02-22 | 2020-08-27 | 武汉友芝友生物制药有限公司 | Cd3 antigen binding fragment and application thereof |
WO2020176748A1 (en) | 2019-02-27 | 2020-09-03 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies |
WO2020176497A1 (en) | 2019-02-26 | 2020-09-03 | Rgenix, Inc. | High-affinity anti-mertk antibodies and uses thereof |
US10766959B2 (en) | 2014-12-11 | 2020-09-08 | Pierre Fabre Medicament | Anti-C10ORF54 antibodies and uses thereof |
WO2020183269A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
WO2020183271A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
WO2020183270A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
WO2020183418A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-il12/il23 antibody compositions |
US10781264B2 (en) | 2016-02-03 | 2020-09-22 | Amgen Research (Munich) Gmbh | PSMA and CD3 bispecific T cell engaging antibody constructs |
WO2020188466A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Biotech, Inc. | Method of treating psoriasis in pediatric subjects with anti-il12/il23 antibody |
US10787522B2 (en) | 2014-03-21 | 2020-09-29 | Regeneron Pharmaceuticals, Inc. | VL antigen binding proteins exhibiting distinct binding characteristics |
WO2020198731A2 (en) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Engineered antibodies |
US10793633B2 (en) | 2011-09-30 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
US10800847B2 (en) | 2012-01-11 | 2020-10-13 | Dr. Mepur Ravindranath | Anti-HLA class-IB antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (IVIG) useful as therapeutic IVIG mimetics and methods of their use |
WO2020216947A1 (en) | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
EP3733868A2 (en) | 2013-10-28 | 2020-11-04 | DOTS Technology Corp. | Allergen detection |
US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
WO2020226986A2 (en) | 2019-05-03 | 2020-11-12 | Genentech, Inc. | Methods of treating cancer with an anti-pd-l1 antibody |
EP3741389A1 (en) | 2019-05-23 | 2020-11-25 | Fibrogen, Inc. | A connective tissue growth factor (ctgf) inhibitor for use in the treatment of muscular dystrophies |
US10849992B1 (en) | 2015-04-07 | 2020-12-01 | Alector Llc | Methods of screening for sortilin binding antagonists |
WO2020243477A2 (en) | 2019-05-30 | 2020-12-03 | Amgen Inc. | Engineering the hinge region to drive antibody dimerization |
US10857237B2 (en) | 2015-05-05 | 2020-12-08 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and MRI and/or X-ray contrast agents |
WO2020245676A1 (en) | 2019-06-03 | 2020-12-10 | Janssen Biotech, Inc. | Anti-tnf antibody compositions, and methods for the treatment of psoriatic arthritis |
WO2020245677A1 (en) | 2019-06-03 | 2020-12-10 | Janssen Biotech, Inc. | Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis |
US10865238B1 (en) | 2017-05-05 | 2020-12-15 | Duke University | Complement factor H antibodies |
WO2020252442A1 (en) | 2019-06-13 | 2020-12-17 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
US10869924B2 (en) | 2015-06-16 | 2020-12-22 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
WO2020264384A1 (en) | 2019-06-28 | 2020-12-30 | Amgen Inc. | Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins |
US10881085B2 (en) | 2014-03-21 | 2021-01-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
WO2021001458A1 (en) | 2019-07-01 | 2021-01-07 | Tonix Pharma Holdings Limited | Anti-cd154 antibodies and uses thereof |
EP3763737A1 (en) | 2019-07-12 | 2021-01-13 | Eberhard Karls Universität Tübingen | Binding compounds of penicillin binding protein 2 a |
WO2021005009A1 (en) | 2019-07-05 | 2021-01-14 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
US10905772B2 (en) | 2017-01-17 | 2021-02-02 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using GLP-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (GIPR) |
WO2021021676A1 (en) | 2019-07-26 | 2021-02-04 | Amgen Inc. | Anti-il13 antigen binding proteins |
US10914729B2 (en) | 2017-05-22 | 2021-02-09 | The Trustees Of Princeton University | Methods for detecting protein binding sequences and tagging nucleic acids |
WO2021028752A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Anti-tfn antibodies for treating type i diabetes |
US10927342B2 (en) | 2015-08-04 | 2021-02-23 | Regeneran Pharmaceuticals, Inc. | Taurine supplemented cell culture medium and methods of use |
EP3783029A1 (en) | 2015-05-12 | 2021-02-24 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer |
US10935544B2 (en) | 2015-09-04 | 2021-03-02 | Obi Pharma, Inc. | Glycan arrays and method of use |
US10934363B2 (en) | 2015-08-11 | 2021-03-02 | Legend Biotech Usa Inc. | Chimeric antigen receptors based on single domain antibodies and methods of use thereof |
US10934571B2 (en) | 2002-07-18 | 2021-03-02 | Merus N.V. | Recombinant production of mixtures of antibodies |
US10934337B2 (en) | 2019-03-15 | 2021-03-02 | Cartesian Therapeutics, Inc. | Anti-BCMA chimeric antigen receptors |
WO2021042019A1 (en) | 2019-08-30 | 2021-03-04 | Agenus Inc. | Anti-cd96 antibodies and methods of use thereof |
EP3789036A1 (en) | 2013-07-16 | 2021-03-10 | F. Hoffmann-La Roche AG | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
WO2021043206A1 (en) | 2019-09-03 | 2021-03-11 | 百奥泰生物制药股份有限公司 | Anti-tigit immunosuppressant and application thereof |
WO2021046159A1 (en) | 2019-09-04 | 2021-03-11 | Genentech, Inc. | Cd8 binding agents and uses thereof |
WO2021050640A1 (en) | 2019-09-10 | 2021-03-18 | Amgen Inc. | Purification method for bispecific antigen-binding polypeptides with enhanced protein l capture dynamic binding capacity |
WO2021050645A1 (en) | 2019-09-12 | 2021-03-18 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
WO2021062323A1 (en) | 2019-09-26 | 2021-04-01 | Stcube & Co. | Antibodies specific to glycosylated ctla-4 and methods of use thereof |
WO2021062085A1 (en) | 2019-09-27 | 2021-04-01 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
EP3804745A1 (en) | 2014-04-25 | 2021-04-14 | The Brigham and Women's Hospital, Inc. | Methods to manipulate alpha-fetoprotein (afp) |
WO2021072277A1 (en) | 2019-10-09 | 2021-04-15 | Stcube & Co. | Antibodies specific to glycosylated lag3 and methods of use thereof |
US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
US10982002B2 (en) | 2018-03-12 | 2021-04-20 | Zoetis Services Llc | Anti-NGF antibodies and methods thereof |
WO2021077051A1 (en) | 2019-10-18 | 2021-04-22 | Immunomic Therapeutics, Inc | Improved lamp constructs comprising cancer antigens |
WO2021076930A1 (en) | 2019-10-18 | 2021-04-22 | The Regents Of The University Of California | Plxdc activators and their use in the treatment of blood vessel disorders |
EP3811969A1 (en) | 2018-10-24 | 2021-04-28 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Immunization scheme for variant surface glycoprotein carriers |
WO2021087406A1 (en) | 2019-11-01 | 2021-05-06 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
WO2021084124A1 (en) | 2019-11-01 | 2021-05-06 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFβ AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
US11000601B2 (en) | 2016-11-21 | 2021-05-11 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
WO2021092355A1 (en) | 2019-11-08 | 2021-05-14 | Amgen Inc. | Engineering charge pair mutations for pairing of hetero-igg molecules |
WO2021092171A1 (en) | 2019-11-06 | 2021-05-14 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
WO2021089704A1 (en) | 2019-11-05 | 2021-05-14 | Merck Patent Gmbh | Combined inhibition of pd-1, tgfb and tigit for the treatment of cancer |
US11008389B2 (en) | 2011-03-16 | 2021-05-18 | Sanofi | Uses of a dual V region antibody-like protein |
EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
WO2021097344A1 (en) | 2019-11-13 | 2021-05-20 | Amgen Inc. | Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules |
US11014982B2 (en) | 2017-02-07 | 2021-05-25 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, and methods for the treatment of active ankylosing spondylitis |
US11013800B2 (en) | 2011-05-16 | 2021-05-25 | Evive Biotech Ltd. | Multi-specific Fab fusion proteins comprising a CD3-binding Fab fragment with N-terminal fusion to binding domains and methods of use |
EP3825330A1 (en) | 2019-11-19 | 2021-05-26 | International-Drug-Development-Biotech | Anti-cd117 antibodies and methods of use thereof |
WO2021102049A1 (en) | 2019-11-19 | 2021-05-27 | Amgen Inc. | Novel multispecific antibody format |
WO2021113655A1 (en) | 2019-12-05 | 2021-06-10 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2021118930A2 (en) | 2019-12-09 | 2021-06-17 | Genentech, Inc. | Anti-pd-l1 antibody formulations |
WO2021119400A1 (en) | 2019-12-12 | 2021-06-17 | Alector Llc | Methods of use of anti-cd33 antibodies |
US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
US11041020B2 (en) | 2017-01-30 | 2021-06-22 | Janssen Biotech, Inc. | Methods for the treatment of active Psoriatic Arthritis |
WO2021127528A1 (en) | 2019-12-20 | 2021-06-24 | Amgen Inc. | Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors |
WO2021130383A1 (en) | 2019-12-27 | 2021-07-01 | Affimed Gmbh | Method for the production of bispecific fcyriii x cd30 antibody construct |
EP3848709A1 (en) | 2015-12-31 | 2021-07-14 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating esophageal cancer |
WO2021142086A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
US11072654B2 (en) | 2014-07-17 | 2021-07-27 | Novo Nordisk A/S | Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity |
WO2021150824A1 (en) | 2020-01-22 | 2021-07-29 | Amgen Research (Munich) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
WO2021155149A1 (en) | 2020-01-31 | 2021-08-05 | Genentech, Inc. | Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine |
US11085924B2 (en) | 2015-12-31 | 2021-08-10 | Syncerus S.À. R.L. | Compositions and methods for assessing the risk of cancer occurrence |
US11084875B2 (en) | 2014-08-08 | 2021-08-10 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
EP3862365A1 (en) | 2016-01-08 | 2021-08-11 | F. Hoffmann-La Roche AG | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies |
US11090336B2 (en) | 2019-03-27 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Tn-MUC1 chimeric antigen receptor (CAR) T cell therapy |
WO2021160133A1 (en) | 2020-02-13 | 2021-08-19 | 湖南华康恒健生物技术有限公司 | Anti-bcma antibody, pharmaceutical composition of same, and applications thereof |
US11103589B2 (en) | 2016-01-08 | 2021-08-31 | Apg Therapeutics, Inc. | Polyethylenimine (PEI)-polypeptide conjugates and methods of use thereof |
WO2021173565A1 (en) | 2020-02-24 | 2021-09-02 | Alector Llc | Methods of use of anti-trem2 antibodies |
US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
WO2021178896A1 (en) | 2020-03-06 | 2021-09-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
WO2021183861A1 (en) | 2020-03-12 | 2021-09-16 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor |
WO2021183207A1 (en) | 2020-03-10 | 2021-09-16 | Massachusetts Institute Of Technology | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER |
WO2021188851A1 (en) | 2020-03-19 | 2021-09-23 | Amgen Inc. | Antibodies against mucin 17 and uses thereof |
WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2021203030A2 (en) | 2020-04-03 | 2021-10-07 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2021197340A1 (en) | 2020-03-31 | 2021-10-07 | 百奥泰生物制药股份有限公司 | Antibody and fusion protein for treating coronaviruses and use thereof |
WO2021202473A2 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Engineered antibodies |
WO2021202959A1 (en) | 2020-04-03 | 2021-10-07 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2021207449A1 (en) | 2020-04-09 | 2021-10-14 | Merck Sharp & Dohme Corp. | Affinity matured anti-lap antibodies and uses thereof |
WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
WO2021211331A1 (en) | 2020-04-13 | 2021-10-21 | Abbott Point Of Care Inc. | METHODS, COMPLEXES AND KITS FOR DETECTING OR DETERMINING AN AMOUNT OF A ß-CORONAVIRUS ANTIBODY IN A SAMPLE |
US11155601B2 (en) | 2015-03-06 | 2021-10-26 | CSL Behring Lengnau AG | Modified von Willebrand factor having improved half-life |
WO2021222313A1 (en) | 2020-04-27 | 2021-11-04 | Magenta Therapeutics, Inc. | Methods and compositions for transducing hematopoietic stem and progenitor cells in vivo |
WO2021222181A2 (en) | 2020-04-27 | 2021-11-04 | The Regents Of The University Of California | Isoform-independent antibodies to lipoprotein(a) |
WO2021222167A1 (en) | 2020-04-28 | 2021-11-04 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
EP3909983A1 (en) | 2015-12-02 | 2021-11-17 | STCube & Co. Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
WO2021236638A1 (en) | 2020-05-19 | 2021-11-25 | Amgen Inc. | Mageb2 binding constructs |
EP3915641A1 (en) | 2020-05-27 | 2021-12-01 | International-Drug-Development-Biotech | Anti-cd5 antibodies and methods of use thereof |
WO2021243320A2 (en) | 2020-05-29 | 2021-12-02 | Amgen Inc. | Adverse effects-mitigating administration of a bispecific antibody construct binding to cd33 and cd3 |
US11191851B2 (en) | 2012-08-17 | 2021-12-07 | Musc Foundation For Research Development | Anti-C3d antibody conjugates and methods of detecting complement activation |
WO2021247908A1 (en) | 2020-06-03 | 2021-12-09 | Bionecure Therapeutics, Inc. | Trophoblast cell-surface antigen-2 (trop-2) antibodies |
WO2021249969A1 (en) | 2020-06-10 | 2021-12-16 | Merck Patent Gmbh | Combination product for the treatment of cancer diseases |
US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
WO2021257503A1 (en) | 2020-06-16 | 2021-12-23 | Genentech, Inc. | Methods and compositions for treating triple-negative breast cancer |
WO2021257124A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
WO2022006562A1 (en) | 2020-07-03 | 2022-01-06 | Dana-Farber Cancer Institute, Inc. | Multispecific coronavirus antibodies |
EP3936524A2 (en) | 2015-05-11 | 2022-01-12 | F. Hoffmann-La Roche AG | Compositions and methods of treating lupus nephritis |
WO2022010797A2 (en) | 2020-07-07 | 2022-01-13 | Bionecure Therapeutics, Inc. | Novel maytansinoids as adc payloads and their use for the treatment of cancer |
WO2022008027A1 (en) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
US11230697B2 (en) | 2006-09-01 | 2022-01-25 | Therapeutic Human Polyclonals Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
WO2022020636A2 (en) | 2020-07-24 | 2022-01-27 | Amgen Inc. | Immunogens derived from sars-cov2 spike protein |
WO2022026699A1 (en) | 2020-07-31 | 2022-02-03 | Genentech, Inc. | Anti-integrin beta7 antibody formulations and devices |
US11241417B2 (en) | 2018-06-21 | 2022-02-08 | Yumanity Therapeutics, Inc. | Compositions and methods for the treatment and prevention of neurological disorders |
WO2022031804A1 (en) | 2020-08-04 | 2022-02-10 | Abbott Laboratories | Improved methods and kits for detecting sars-cov-2 protein in a sample |
WO2022028608A1 (en) | 2020-08-07 | 2022-02-10 | 百奥泰生物制药股份有限公司 | Anti pd-l1 antibody and application thereof |
WO2022031749A1 (en) | 2020-08-03 | 2022-02-10 | Genentech, Inc. | Diagnostic and therapeutic methods for lymphoma |
EP3954999A1 (en) | 2015-12-31 | 2022-02-16 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating ovarian cancer |
EP3954998A1 (en) | 2015-12-31 | 2022-02-16 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating gastric cancer |
WO2022036146A1 (en) | 2020-08-12 | 2022-02-17 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
US11253609B2 (en) | 2017-03-03 | 2022-02-22 | Seagen Inc. | Glycan-interacting compounds and methods of use |
US11253590B2 (en) | 2015-12-02 | 2022-02-22 | Stsciences, Inc. | Antibodies specific to glycosylated BTLA (B- and T- lymphocyte attenuator) |
WO2022040466A1 (en) | 2020-08-20 | 2022-02-24 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in fab region |
US11259510B2 (en) | 2015-04-06 | 2022-03-01 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
WO2022047381A1 (en) | 2020-08-31 | 2022-03-03 | Genentech, Inc. | Methods for producing antibodies |
WO2022042659A1 (en) | 2020-08-26 | 2022-03-03 | 湖南华康恒健生物技术有限公司 | Anti-ox40 antibody, and pharmaceutical composition and application thereof |
US11270782B2 (en) | 2014-11-19 | 2022-03-08 | Koninklijke Philips N.V. | Diagnostic method employing HNL |
US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
WO2022051549A1 (en) | 2020-09-04 | 2022-03-10 | Rutgers, The State University Of New Jersey | Sars-cov-2 vaccines and antibodies |
WO2022050954A1 (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
US11274154B2 (en) | 2016-10-06 | 2022-03-15 | Pfizer Inc. | Dosing regimen of avelumab for the treatment of cancer |
WO2022056490A1 (en) | 2020-09-14 | 2022-03-17 | Vor Biopharma, Inc. | Chimeric antigen receptors for treatment of cancer |
US11292850B2 (en) | 2018-03-21 | 2022-04-05 | ALX Oncology Inc. | Antibodies against signal-regulatory protein α and methods of use |
WO2022074206A1 (en) | 2020-10-08 | 2022-04-14 | Affimed Gmbh | Trispecific binders |
WO2022076474A2 (en) | 2020-10-07 | 2022-04-14 | Amgen Inc. | Rational selection of building blocks for the assembly of multispecific antibodies |
WO2022081436A1 (en) | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
WO2022087274A1 (en) | 2020-10-21 | 2022-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies that neutralize type-i interferon (ifn) activity |
US11319526B2 (en) | 2008-05-02 | 2022-05-03 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
EP3992205A1 (en) | 2020-11-03 | 2022-05-04 | Rheinische Friedrich-Wilhelms-Universität Bonn | Sars coronavirus-2 spike protein binding compounds |
WO2022090527A1 (en) | 2020-11-02 | 2022-05-05 | Ares Trading S.A. | Combination treatment of cancer |
WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
WO2022090529A1 (en) | 2020-11-02 | 2022-05-05 | Ares Trading S.A. | Combination treatment of cancer |
WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
WO2022096698A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Polypeptide constructs binding to cd3 |
WO2022095970A1 (en) | 2020-11-06 | 2022-05-12 | 百奥泰生物制药股份有限公司 | Bispecific antibody and use thereof |
WO2022096716A2 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Multitargeting bispecific antigen-binding molecules of increased selectivity |
WO2022096700A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Research (Munich) Gmbh | Polypeptide constructs selectively binding to cldn6 and cd3 |
WO2022096704A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Antigen binding domain with reduced clipping rate |
WO2022096536A1 (en) | 2020-11-03 | 2022-05-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Target-cell restricted, costimulatory, bispecific and bivalent anti-cd28 antibodies |
US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
WO2022103773A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Novel linkers of multispecific antigen binding domains |
WO2022100694A1 (en) | 2020-11-12 | 2022-05-19 | 迈威(上海)生物科技股份有限公司 | Antibody and preparation method therefor |
WO2022106205A1 (en) | 2020-11-18 | 2022-05-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Corona virus spike protein binding compounds |
WO2022119841A1 (en) | 2020-12-01 | 2022-06-09 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
US11357849B2 (en) | 2016-03-07 | 2022-06-14 | Musc Foundation For Research Development | Anti-nucleolin antibodies |
US11370833B2 (en) | 2014-09-15 | 2022-06-28 | Genentech, Inc. | Antibody formulations |
WO2022140797A1 (en) | 2020-12-23 | 2022-06-30 | Immunowake Inc. | Immunocytokines and uses thereof |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
WO2022147147A1 (en) | 2020-12-30 | 2022-07-07 | Abbott Laboratories | Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample |
WO2022150452A1 (en) | 2021-01-06 | 2022-07-14 | Seth Lederman | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
US11391733B2 (en) | 2015-08-20 | 2022-07-19 | Roche Diagnostics Operations, Inc. | Particle-based immunoassay using a pegylated analyte-specific binding agent |
US11396546B2 (en) | 2018-07-13 | 2022-07-26 | Alector Llc | Anti-Sortilin antibodies and methods of use thereof |
US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
WO2022162201A1 (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses |
WO2022162203A1 (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses |
US11434302B2 (en) | 2016-02-03 | 2022-09-06 | Amgen Research (Munich) Gmbh | Bispecific T cell engaging antibody constructs |
WO2022187591A1 (en) | 2021-03-05 | 2022-09-09 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
WO2022190033A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
WO2022192898A2 (en) | 2021-03-10 | 2022-09-15 | Immunowake Inc. | Immunomodulatory molecules and uses thereof |
WO2022190034A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody |
US11447573B2 (en) | 2016-07-20 | 2022-09-20 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
WO2022198192A1 (en) | 2021-03-15 | 2022-09-22 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
WO2022212831A1 (en) | 2021-04-02 | 2022-10-06 | Amgen Inc. | Mageb2 binding constructs |
WO2022216898A1 (en) | 2021-04-09 | 2022-10-13 | Genentech, Inc. | Combination therapy with a raf inhibitor and a pd-1 axis inhibitor |
US11472881B2 (en) | 2016-10-11 | 2022-10-18 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against CTLA-4 |
US11471487B2 (en) | 2014-10-31 | 2022-10-18 | The Trustees Of The University Of Pennsylvania | Compositions and methods of stimulating and expanding T cells |
WO2022225921A1 (en) | 2021-04-20 | 2022-10-27 | Amgen Inc. | Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly |
US11485782B2 (en) | 2018-03-14 | 2022-11-01 | Beijing Xuanyi Pharmasciences Co., Ltd. | Anti-claudin 18.2 antibodies |
WO2022232376A1 (en) | 2021-04-29 | 2022-11-03 | Amgen Inc. | Methods for reducing low molecular weight species of recombinantly-produced proteins |
WO2022234102A1 (en) | 2021-05-06 | 2022-11-10 | Amgen Research (Munich) Gmbh | Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases |
WO2022235628A1 (en) | 2021-05-04 | 2022-11-10 | Regeneron Pharmaceuticals, Inc. | Multispecific fgf21 receptor agonists and their uses |
WO2022235940A1 (en) | 2021-05-06 | 2022-11-10 | Dana-Farber Cancer Institute, Inc. | Antibodies against alk and methods of use thereof |
WO2022233718A2 (en) | 2021-05-03 | 2022-11-10 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
WO2022245920A1 (en) | 2021-05-18 | 2022-11-24 | Abbott Laboratories | Methods of evaluating brain injury in a pediatric subject |
WO2022248380A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
WO2022258622A1 (en) | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
WO2022266034A1 (en) | 2021-06-14 | 2022-12-22 | Abbott Laboratories | Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind |
WO2022263357A1 (en) | 2021-06-14 | 2022-12-22 | Argenx Iip Bv | Anti-il-9 antibodies and methods of use thereof |
US11535670B2 (en) | 2016-05-11 | 2022-12-27 | Huyabio International, Llc | Combination therapies of HDAC inhibitors and PD-L1 inhibitors |
WO2023281462A1 (en) | 2021-07-09 | 2023-01-12 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
WO2023281466A1 (en) | 2021-07-09 | 2023-01-12 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-il12/il23 antibody compositions |
WO2023281463A1 (en) | 2021-07-09 | 2023-01-12 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
WO2023007023A1 (en) | 2021-07-30 | 2023-02-02 | Affimed Gmbh | Duplexbodies |
WO2023010118A1 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same |
WO2023014863A1 (en) | 2021-08-05 | 2023-02-09 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
US11576984B2 (en) | 2018-03-26 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with humanized immunoglobulin heavy chain constant region genes and method of using |
US11578426B2 (en) | 2017-08-21 | 2023-02-14 | Adagene Inc. | Dynamic human heavy chain antibody libraries |
WO2023016826A2 (en) | 2021-08-05 | 2023-02-16 | Vaccinvent Gmbh | Method and means for enhancing therapeutic antibodies |
WO2023018803A1 (en) | 2021-08-10 | 2023-02-16 | Byomass Inc. | Anti-gdf15 antibodies, compositions and uses thereof |
US11585014B2 (en) | 2017-08-21 | 2023-02-21 | Adagene Inc. | Dynamic human antibody light chain libraries |
EP4137518A1 (en) | 2013-02-06 | 2023-02-22 | Inhibrx, Inc. | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
WO2023023489A2 (en) | 2021-08-17 | 2023-02-23 | Hemogenyx Pharmaceuticals Llc | Bispecific anti-flt3/cd3 antibodies and methods of use |
WO2023023491A1 (en) | 2021-08-16 | 2023-02-23 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
US11596620B2 (en) | 2013-03-13 | 2023-03-07 | F. Hoffmann-La Roche Ag | Formulations with reduced oxidation |
WO2023034571A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
WO2023034569A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
WO2023034777A1 (en) | 2021-08-31 | 2023-03-09 | Abbott Laboratories | Methods and systems of diagnosing brain injury |
WO2023056268A1 (en) | 2021-09-30 | 2023-04-06 | Abbott Laboratories | Methods and systems of diagnosing brain injury |
WO2023069421A1 (en) | 2021-10-18 | 2023-04-27 | Byomass Inc. | Anti-activin a antibodies, compositions and uses thereof |
WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
WO2023073615A1 (en) | 2021-10-29 | 2023-05-04 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
US11643456B2 (en) | 2016-07-29 | 2023-05-09 | Obi Pharma, Inc. | Human antibodies, pharmaceutical compositions and methods |
US11642400B2 (en) | 2016-07-27 | 2023-05-09 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
WO2023078968A1 (en) | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Bispecific cd16a binders |
WO2023079493A1 (en) | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Bispecific cd16a binders |
WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
US11649291B2 (en) | 2016-05-24 | 2023-05-16 | Insmed Incorporated | Antibodies and methods of making same |
WO2023084488A1 (en) | 2021-11-15 | 2023-05-19 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
WO2023097024A1 (en) | 2021-11-24 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Antibodies against ctla-4 and methods of use thereof |
WO2023095000A1 (en) | 2021-11-23 | 2023-06-01 | Janssen Biotech, Inc. | Method of treating ulcerative colitis with anti-il23 specific antibody |
WO2023102384A1 (en) | 2021-11-30 | 2023-06-08 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
WO2023114978A1 (en) | 2021-12-17 | 2023-06-22 | Abbott Laboratories | Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples |
WO2023114543A2 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Platform for antibody discovery |
WO2023111168A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
WO2023114544A1 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Antibodies and uses thereof |
WO2023122213A1 (en) | 2021-12-22 | 2023-06-29 | Byomass Inc. | Targeting gdf15-gfral pathway cross-reference to related applications |
WO2023129942A1 (en) | 2021-12-28 | 2023-07-06 | Abbott Laboratories | Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
WO2023139292A1 (en) | 2022-01-24 | 2023-07-27 | Cambridge Enterprise Limited | Tau therapy |
US11713353B2 (en) | 2018-01-15 | 2023-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against PD-1 |
WO2023147107A1 (en) | 2022-01-31 | 2023-08-03 | Byomass Inc. | Myeloproliferative conditions |
US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
WO2023150652A1 (en) | 2022-02-04 | 2023-08-10 | Abbott Laboratories | Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample |
WO2023164516A1 (en) | 2022-02-23 | 2023-08-31 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2023170216A1 (en) | 2022-03-11 | 2023-09-14 | Astrazeneca Ab | A SCORING METHOD FOR AN ANTI-FRα ANTIBODY-DRUG CONJUGATE THERAPY |
WO2023169896A1 (en) | 2022-03-09 | 2023-09-14 | Astrazeneca Ab | BINDING MOLECULES AGAINST FRα |
EP4245772A1 (en) | 2022-03-18 | 2023-09-20 | Netris Pharma | Anti-netrin-1 antibody to treat liver inflammation |
EP4248976A2 (en) | 2007-08-23 | 2023-09-27 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) |
EP4249509A1 (en) | 2022-03-22 | 2023-09-27 | Netris Pharma | Anti-netrin-1 antibody against arthritis-associated pain |
WO2023186968A1 (en) | 2022-03-29 | 2023-10-05 | Netris Pharma | Novel mcl-1 inhibitor and combination of mcl-1 and a bh3 mimetic, such as a bcl-2 inhibitor |
WO2023187707A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of treating mild to moderate psoriasis with il-23 specific antibody |
US11780911B2 (en) | 2019-05-23 | 2023-10-10 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
WO2023194539A1 (en) | 2022-04-07 | 2023-10-12 | Heidelberg Pharma Research Gmbh | Methods of improving the therapeutic index of amatoxin-antibody conjugates |
WO2023201201A1 (en) | 2022-04-10 | 2023-10-19 | Immunomic Therapeutics, Inc. | Bicistronic lamp constructs comprising immune response enhancing genes and methods of use thereof |
WO2023215498A2 (en) | 2022-05-05 | 2023-11-09 | Modernatx, Inc. | Compositions and methods for cd28 antagonism |
WO2023218027A1 (en) | 2022-05-12 | 2023-11-16 | Amgen Research (Munich) Gmbh | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
WO2023223265A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for evaluating and treating psoriatic arthritis with il23 antibody |
US11827713B2 (en) | 2017-06-27 | 2023-11-28 | Nanjing Legend Biotech Co., Ltd. | Chimeric antibody immune effector cell engagers and methods of use thereof |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
EP4295911A2 (en) | 2014-11-05 | 2023-12-27 | Annexon, Inc. | Humanized anti-complement factor c1q antibodies and uses thereof |
WO2024006876A1 (en) | 2022-06-29 | 2024-01-04 | Abbott Laboratories | Magnetic point-of-care systems and assays for determining gfap in biological samples |
WO2024015953A1 (en) | 2022-07-15 | 2024-01-18 | Danisco Us Inc. | Methods for producing monoclonal antibodies |
US11884739B2 (en) | 2014-05-27 | 2024-01-30 | Academia Sinica | Anti-CD20 glycoantibodies and uses thereof |
US11884729B2 (en) | 2018-06-29 | 2024-01-30 | ApitBio, Inc | Anti-L1CAM antibodies and uses thereof |
US11891439B2 (en) | 2017-12-28 | 2024-02-06 | Astute Medical, Inc. | Antibodies and assays for CCL14 |
US11897950B2 (en) | 2019-12-06 | 2024-02-13 | Augusta University Research Institute, Inc. | Osteopontin monoclonal antibodies |
US11905327B2 (en) | 2017-12-28 | 2024-02-20 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against TIGIT |
WO2024039670A1 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against cldn4 and methods of use thereof |
WO2024039672A2 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against msln and methods of use thereof |
US11912754B2 (en) | 2017-10-12 | 2024-02-27 | Immunowake Inc. | VEGFR-antibody light chain fusion protein |
WO2024059708A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Biomarkers and methods for differentiating between mild and supermild traumatic brain injury |
WO2024059675A2 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Bispecific molecule stabilizing composition |
Families Citing this family (168)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050287630A1 (en) * | 1995-04-27 | 2005-12-29 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US20050241006A1 (en) * | 1995-04-27 | 2005-10-27 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
US6541212B2 (en) | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
AU777918B2 (en) * | 1997-05-05 | 2004-11-04 | Amgen Fremont Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US7883704B2 (en) * | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
DK1488806T3 (en) | 1999-06-01 | 2016-02-08 | Biogen Ma Inc | Blocking monoclonal antibody to VLA-1 and its use in the treatment of vascular disorders |
EP1326626B1 (en) | 2000-10-18 | 2020-04-01 | Immunex Corporation | Methods for treating rheumatoid arthritis using il-17 antagonists |
JP4303475B2 (en) | 2001-04-13 | 2009-07-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Antibody against VLA-1 |
EP1575491A4 (en) * | 2002-05-20 | 2006-09-27 | Abgenix Inc | Treatment of renal carcinoma using antibodies against the egfr |
ES2635497T3 (en) | 2004-07-22 | 2017-10-04 | Erasmus University Medical Center Rotterdam | Binding molecules |
CA2478458A1 (en) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
US20090202527A1 (en) | 2004-11-19 | 2009-08-13 | Biogen Idec Ma Inc. | Treatment for multiple sclerosis |
CA2589379A1 (en) * | 2004-12-03 | 2006-06-08 | Biogen Idec Ma Inc. | Delaying or preventing onset of multiple sclerosis |
EP2332408B1 (en) | 2005-02-17 | 2013-11-13 | Biogen Idec MA Inc. | Treating neurological disorders |
WO2006094134A2 (en) | 2005-03-02 | 2006-09-08 | Biogen Idec Ma Inc. | Kim-1 antibodies for treatment of th2-mediated conditions |
CN102989012B (en) | 2005-03-31 | 2015-05-13 | 通用医疗公司 | Monitoring and modulating hgf/hgfr activity |
RS61229B1 (en) | 2005-04-04 | 2021-01-29 | Biogen Ma Inc | Methods for evaluating an immune response to a therapeutic agent |
JP5339901B2 (en) | 2005-05-10 | 2013-11-13 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Treatment and evaluation of inflammatory injury |
HUE030701T2 (en) | 2005-05-27 | 2017-05-29 | Biogen Ma Inc | Tweak binding antibodies |
WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
PE20070796A1 (en) * | 2005-10-24 | 2007-08-15 | Wyeth Corp | PROTEIN PRODUCTION METHOD USING ANTI-SENESCENCE COMPOUNDS |
JP2009515878A (en) | 2005-11-12 | 2009-04-16 | イーライ リリー アンド カンパニー | Anti-EGFR antibody |
US20070134249A1 (en) * | 2005-12-08 | 2007-06-14 | Genitope Corporation | Combination therapy and antibody panels |
US7745587B2 (en) | 2005-12-30 | 2010-06-29 | Dyax Corp. | Antibodies that bind MMP-14 |
ES2396440T3 (en) | 2006-01-18 | 2013-02-21 | The General Hospital Corporation | Methods of increasing lymphatic function |
US20090307787A1 (en) | 2006-01-25 | 2009-12-10 | Franklin Gerardus Grosveld | Generation of heavy-chain only antibodies in transgenic animals |
TW200744634A (en) | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
TWI417301B (en) | 2006-02-21 | 2013-12-01 | Wyeth Corp | Antibodies against human il-22 and uses therefor |
EP2034830B1 (en) * | 2006-05-25 | 2014-09-03 | Biogen Idec MA Inc. | Anti-vla-1 antibody for treating stroke |
US20090053210A1 (en) | 2006-09-01 | 2009-02-26 | Roland Buelow | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
US7833527B2 (en) * | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
JP2010506839A (en) * | 2006-10-12 | 2010-03-04 | ワイス エルエルシー | Methods and compositions with reduced opalescence |
CA2666317C (en) | 2006-11-03 | 2013-08-06 | Wyeth | Glycolysis-inhibiting substances in cell culture |
WO2008101352A1 (en) * | 2007-02-22 | 2008-08-28 | Simonson Roger M | Magnetic filter and magnetic filtering assembly |
EP2486928A1 (en) | 2007-02-27 | 2012-08-15 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
CN101679507A (en) * | 2007-03-29 | 2010-03-24 | 艾博特公司 | crystalline anti-human il-12 antibodies |
TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
AU2008266051B2 (en) | 2007-06-14 | 2014-07-31 | Biogen Ma Inc. | Antibody formulations |
US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
CA2710471C (en) | 2007-12-26 | 2018-06-05 | Biotest Ag | Immunoconjugates targeting cd138 and uses thereof |
CN101945892B (en) | 2007-12-26 | 2017-11-24 | 生物测试股份公司 | For the method and reagent of the targeting for improving the tumour cell to expressing CD138 |
EP2271758B1 (en) * | 2008-04-14 | 2018-09-12 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
KR101634719B1 (en) | 2008-04-25 | 2016-06-29 | 다이액스 코포레이션 | Antibodies against fcrn and use thereof |
EP2344180A2 (en) | 2008-09-23 | 2011-07-20 | Wyeth LLC | Methods for predicting production of activating signals by cross-linked binding proteins |
EP2349329A4 (en) | 2008-10-14 | 2012-10-31 | Dyax Corp | Use of igf-ii/igf-iie binding for the treatment and prevention of systemic sclerosis associated pulmonary fibrosis |
AR073997A1 (en) | 2008-10-29 | 2010-12-15 | Wyeth Corp | FORMULATIONS OF MOLECULES OF UNION TO ANTIGENO OF UNIQUE DOMAIN. METHOD. KIT |
CA2739352C (en) | 2008-10-29 | 2021-07-13 | Wyeth Llc | Methods for purification of single domain antigen binding molecules |
US20140086919A1 (en) * | 2012-09-24 | 2014-03-27 | Herbert Y. Lin | Methods and compositons for regulating iron homeostasis by modulation of bmp-6 |
NZ592644A (en) * | 2008-11-28 | 2013-09-27 | Abbott Lab | Stable antibody compositions and methods for stabilizing same |
US9085795B2 (en) * | 2009-02-04 | 2015-07-21 | Molecular Innovations, Inc. | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies |
WO2010121141A1 (en) * | 2009-04-17 | 2010-10-21 | Biogen Idec Ma Inc. | Compositions and methods to treat acute myelogenous leukemia |
WO2010126972A1 (en) | 2009-04-29 | 2010-11-04 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Erg monoclonal antibodies |
SI3241435T1 (en) | 2009-07-08 | 2021-11-30 | Kymab Limited, | Animal models and therapeutic molecules |
CN102481380A (en) | 2009-07-09 | 2012-05-30 | 霍夫曼-拉罗奇有限公司 | In vivo tumor vasculature imaging |
EP2464220A4 (en) | 2009-08-13 | 2014-05-07 | Crystal Bioscience Inc | Transgenic animal for production of antibodies having minimal cdrs |
US9377458B2 (en) | 2009-10-11 | 2016-06-28 | Biogen Ma Inc. | Anti-VLA-4 related assays |
TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
WO2011085103A2 (en) | 2010-01-06 | 2011-07-14 | Dyax Corp. | Plasma kallikrein binding proteins |
DK3295957T3 (en) | 2010-01-15 | 2019-10-14 | Kirin Amgen Inc | ANTI IL-17RA ANTIBODY FORMULATION AND THERAPEUTIC REGULATIONS TO TREAT PSORIASIS |
US8865462B2 (en) | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
WO2011100620A2 (en) * | 2010-02-12 | 2011-08-18 | The Regents Of The University Of California | Upar binding agents and methods of use thereof |
SG10201502967RA (en) | 2010-04-16 | 2015-05-28 | Biogen Ma Inc | Anti-vla-4 antibodies |
KR101970944B1 (en) * | 2010-06-22 | 2019-04-23 | 리제너론 파아마슈티컬스, 인크. | Hybrid light chain mice |
WO2012007880A2 (en) | 2010-07-16 | 2012-01-19 | Ablynx Nv | Modified single domain antigen binding molecules and uses thereof |
AU2011286185B2 (en) | 2010-07-26 | 2014-08-14 | Trianni, Inc. | Transgenic animals and methods of use |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
NZ605928A (en) | 2010-07-29 | 2015-02-27 | Eleven Biotherapeutics Inc | Chimeric il-1 receptor type i agonists and antagonists |
EP2420250A1 (en) | 2010-08-13 | 2012-02-22 | Universitätsklinikum Münster | Anti-Syndecan-4 antibodies |
US20140050743A1 (en) | 2011-01-19 | 2014-02-20 | Bayer Intellectual Property Gmbh | Binding proteins to inhibitors of coagulation factors |
WO2012103240A2 (en) | 2011-01-25 | 2012-08-02 | Eleven Biotherapeutics, Inc. | Receptor binding agents |
KR20140018299A (en) | 2011-03-30 | 2014-02-12 | 아블린쓰 엔.브이. | Methods of treating immune disorders with single domain antibodies against tnf-alpha |
WO2012138694A2 (en) | 2011-04-07 | 2012-10-11 | Emory University | Compositions comprising saccharide binding moieties and methods for targeted therapy |
EP2966089B1 (en) | 2011-06-02 | 2020-03-25 | Dyax Corp. | Fc receptor binding proteins |
WO2012170742A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
US9244074B2 (en) | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
WO2013016220A1 (en) | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
SG10201800158XA (en) | 2011-09-22 | 2018-02-27 | Amgen Inc | Cd27l antigen binding proteins |
JP2014533929A (en) | 2011-09-23 | 2014-12-18 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | Bispecific binding molecules for 5T4 and CD3 |
TWI679212B (en) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | Binding molecules for e3 of bcma and cd3 |
EP2814468B1 (en) | 2012-02-16 | 2019-06-19 | Santarus, Inc. | Anti-vla1 (cd49a) antibody pharmaceutical compositions |
US20150037334A1 (en) | 2012-03-01 | 2015-02-05 | Amgen Research (Munich) Gmbh | Long life polypeptide binding molecules |
WO2013151649A1 (en) | 2012-04-04 | 2013-10-10 | Sialix Inc | Glycan-interacting compounds |
EP2847219A1 (en) | 2012-05-07 | 2015-03-18 | Amgen Inc. | Anti-erythropoietin antibodies |
CN104918956A (en) | 2012-05-17 | 2015-09-16 | 索伦托治疗有限公司 | Antigen binding proteins that bind EGFR |
US20140004121A1 (en) | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
TW201425336A (en) | 2012-12-07 | 2014-07-01 | Amgen Inc | BCMA antigen binding proteins |
PT2928923T (en) | 2012-12-10 | 2020-03-27 | Biogen Ma Inc | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
US10717965B2 (en) | 2013-01-10 | 2020-07-21 | Gloriana Therapeutics, Inc. | Mammalian cell culture-produced neublastin antibodies |
EP3888671A3 (en) | 2013-03-11 | 2022-01-05 | Amgen Inc. | Protein formulations |
DK2968468T3 (en) | 2013-03-13 | 2021-07-26 | Buzzard Pharmaceuticals AB | Chimeric cytokine formulations for ocular delivery |
EP2968508B1 (en) | 2013-03-15 | 2022-04-27 | Sanofi Pasteur Biologics, LLC | Antibodies against clostridium difficile toxins and methods of using the same |
CN105392801A (en) | 2013-03-15 | 2016-03-09 | 比奥根Ma公司 | Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies |
US10993420B2 (en) | 2013-03-15 | 2021-05-04 | Erasmus University Medical Center | Production of heavy chain only antibodies in transgenic mammals |
DK3036320T3 (en) | 2013-08-19 | 2021-07-12 | Biogen Ma Inc | MANAGEMENT OF PROTEIN GLYCOSYLATION BY CULTIVATION MEDIA ADDITION AND CELL CULTURE PROCESS PARAMETERS |
JP2017502002A (en) | 2013-12-09 | 2017-01-19 | ニューヨーク・ユニバーシティ | Composition and method for phagocytic cell delivery of anti-staphylococcal agents |
US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US8992927B1 (en) | 2014-07-15 | 2015-03-31 | Kymab Limited | Targeting human NAV1.7 variants for treatment of pain |
US8986694B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Targeting human nav1.7 variants for treatment of pain |
US9034332B1 (en) | 2014-07-15 | 2015-05-19 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
US8945560B1 (en) | 2014-07-15 | 2015-02-03 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
RU2714902C2 (en) | 2013-12-19 | 2020-02-20 | Новартис Аг | Chimeric human mesotheliogen antigen receptors and use thereof |
WO2015095809A1 (en) | 2013-12-20 | 2015-06-25 | Biogen Idec Ma Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
DK3122869T3 (en) | 2014-03-24 | 2019-09-09 | Biogen Ma Inc | PROCEDURES FOR REDUCING GLUTAMINE DEPRESSION IN MAMMAL CULTURE CULTURE |
US9150660B1 (en) | 2014-07-15 | 2015-10-06 | Kymab Limited | Precision Medicine by targeting human NAV1.8 variants for treatment of pain |
CA2959428A1 (en) | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
MA41685A (en) | 2014-10-17 | 2017-08-22 | Biogen Ma Inc | COPPER SUPPLEMENT FOR THE REGULATION OF GLYCOSYLATION IN A MAMMAL CELL CULTURE PROCESS |
MA40864A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | HYPOTAURINE, GABA, BETA-ALANINE AND CHOLINE FOR THE REGULATION OF THE ACCUMULATION OF RESIDUAL BY-PRODUCTS IN MAMMAL CELL CULTURE PROCESSES |
US11033637B2 (en) | 2014-11-21 | 2021-06-15 | University Of Maryland, Baltimore | Targeted structure-specific particulate delivery systems |
CN113209306A (en) | 2014-12-09 | 2021-08-06 | 艾伯维公司 | Antibody drug conjugates with cell permeable BCL-XL inhibitors |
SG11201704710PA (en) | 2014-12-09 | 2017-07-28 | Abbvie Inc | Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same |
AU2016311268B2 (en) | 2015-08-24 | 2023-02-02 | Trianni, Inc. | Enhanced production of immunoglobulins |
CN108135968A (en) | 2015-08-28 | 2018-06-08 | 阿穆尼克斯运营公司 | Chimeric polyeptides assembly and its preparation and application |
EP3356415A1 (en) | 2015-09-29 | 2018-08-08 | Amgen Inc. | Asgr inhibitors |
US10813346B2 (en) | 2015-12-03 | 2020-10-27 | Trianni, Inc. | Enhanced immunoglobulin diversity |
CR20180365A (en) | 2015-12-16 | 2018-09-28 | Amgen Inc | PROTEINS OF UNION TO THE ANTI-TL1A / ANTI-TNF-a BISPECTIVE ANTIGEN AND ITS USES |
AU2017213633B2 (en) | 2016-02-04 | 2023-08-03 | Trianni, Inc. | Enhanced production of immunoglobulins |
SI3462853T1 (en) | 2016-06-03 | 2023-05-31 | Regeneron Pharmaceuticals, Inc. | Rodents expressing exogenous terminal deoxynucleotidyltransferase |
CN109963870B (en) | 2016-06-08 | 2023-07-28 | 艾伯维公司 | anti-B7-H3 antibodies and antibody drug conjugates |
WO2018022479A1 (en) | 2016-07-25 | 2018-02-01 | Biogen Ma Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
EP3510046A4 (en) | 2016-09-07 | 2020-05-06 | The Regents of the University of California | Antibodies to oxidation-specific epitopes |
WO2018140510A1 (en) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
MX2019011599A (en) | 2017-03-30 | 2019-12-19 | Univ Queensland | "chimeric molecules and uses thereof". |
WO2018215535A1 (en) | 2017-05-23 | 2018-11-29 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Novel cd73 antibody, preparation and uses thereof |
CN111065650A (en) | 2017-07-21 | 2020-04-24 | 特里安尼公司 | Single chain VH-L1-Ck-L2-CH 1-antibody |
KR102414120B1 (en) | 2017-08-03 | 2022-06-28 | 암젠 인크 | Interleukin-21 muteins and methods of treatment |
CN116003405A (en) | 2017-09-08 | 2023-04-25 | 美国安进公司 | Inhibitors of KRAS G12C and methods of use thereof |
EP3476942B1 (en) | 2017-10-27 | 2022-01-26 | Trianni, Inc. | Long germline dh genes and long hcdr3 antibodies |
DK3720279T3 (en) * | 2017-12-05 | 2022-10-24 | Regeneron Pharma | Mice with a modified immunoglobulin Lambda light chain and uses thereof |
PE20211270A1 (en) | 2018-01-12 | 2021-07-19 | Amgen Inc | ANTI-PD-1 ANTIBODIES AND TREATMENT METHODS |
BR112020013405A2 (en) | 2018-01-25 | 2020-12-01 | Acm Biolabs Pte Ltd. | polymerosomes comprising a soluble encapsulated antigen, as well as methods of its manufacture and use |
WO2019180272A1 (en) | 2018-03-23 | 2019-09-26 | Fundación Instituto De Investigación Sanitaria De Santiago De Compostela | Anti-leptin affinity reagents for use in the treatment of obesity and other leptin-resistance associated diseases |
JP2021519062A (en) | 2018-03-24 | 2021-08-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for producing therapeutic antibodies against peptide-MHC complexes, and methods of their preparation and use. |
ES2950740T3 (en) | 2018-03-26 | 2023-10-13 | Glycanostics S R O | Means and methods for glycoprofiling of a protein |
JP2021526014A (en) | 2018-06-05 | 2021-09-30 | アムジエン・インコーポレーテツド | Regulation of antibody-dependent cellular cytotoxicity |
EP3629720B1 (en) | 2018-06-14 | 2022-01-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of dh-dh rearrangement in the immunoglobulin heavy chain coding sequences |
EP3827020A1 (en) | 2018-07-24 | 2021-06-02 | Amgen Inc. | Combination of lilrb1/2 pathway inhibitors and pd-1 pathway inhibitors |
EP3850006A1 (en) | 2018-09-11 | 2021-07-21 | Amgen Inc. | Methods of modulating antibody-dependent cell-mediated cytotoxicity |
CN112996539A (en) | 2018-09-12 | 2021-06-18 | Acm生物实验室私人有限公司 | Polymersomes comprising covalently bound antigens, methods of making and uses thereof |
CN112703204A (en) | 2018-09-28 | 2021-04-23 | 安进公司 | Antibodies to soluble BCMA |
WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
CA3118453A1 (en) | 2018-11-02 | 2020-05-07 | The Regents Of The University Of California | Compositions and methods for treating brain injury |
MX2021014931A (en) | 2019-06-07 | 2022-01-24 | Amgen Inc | Bispecific binding constructs with selectively cleavable linkers. |
JP2022538885A (en) | 2019-07-01 | 2022-09-06 | トリアニ・インコーポレイテッド | TRANSGENIC MAMMALS AND USES THEREOF |
WO2021003149A1 (en) | 2019-07-01 | 2021-01-07 | Trianni, Inc. | Transgenic mammals and methods of use |
EP3785536B1 (en) | 2019-08-28 | 2022-01-26 | Trianni, Inc. | Adam6 knockin mice |
EP4069722A1 (en) | 2019-12-02 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
EP4161969A1 (en) | 2020-06-04 | 2023-04-12 | Amgen Inc. | Bispecific binding constructs |
CR20230025A (en) | 2020-06-26 | 2023-10-05 | Amgen Inc | Il-10 muteins and fusion proteins thereof |
TW202216778A (en) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Tigit and cd112r blockade |
WO2022056276A1 (en) | 2020-09-11 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
AU2021393456A1 (en) | 2020-12-03 | 2023-06-29 | Amgen Inc. | Immunoglobuline constructs with multiple binding domains |
AU2021395027A1 (en) | 2020-12-09 | 2023-06-22 | Trianni, Inc. | Heavy chain-only antibodies |
KR20230147048A (en) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | Mice expressing humanized Fc alpha receptors |
EP4051700A1 (en) | 2020-12-23 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
AR124681A1 (en) | 2021-01-20 | 2023-04-26 | Abbvie Inc | ANTI-EGFR ANTIBODY-DRUG CONJUGATES |
CN117440753A (en) | 2021-05-05 | 2024-01-23 | 特里安尼公司 | Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof |
CA3224001A1 (en) | 2021-06-25 | 2022-12-29 | Amgen Inc. | Treatment of cardiovascular disease with trem-1 antigen binding proteins |
WO2023056430A1 (en) | 2021-10-01 | 2023-04-06 | Abcellera Biologics Inc. | Transgenic rodents for cell line identification and enrichment |
WO2023086815A1 (en) | 2021-11-10 | 2023-05-19 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
WO2023137161A1 (en) | 2022-01-14 | 2023-07-20 | Amgen Inc. | Triple blockade of tigit, cd112r, and pd-l1 |
WO2023235415A1 (en) | 2022-06-01 | 2023-12-07 | Genentech, Inc. | Method to identify a patient with an increased likelihood of chemotherapy-induced peripheral neuropathy |
US20240092859A1 (en) | 2022-08-18 | 2024-03-21 | Immunocore Ltd | T cell receptors and fusion proteins thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991000906A1 (en) * | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
WO1994025585A1 (en) * | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1996034096A1 (en) * | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3180111A (en) | 1962-11-05 | 1965-04-27 | United Aircraft Corp | Combined insulating and cooling blanket |
US3180193A (en) | 1963-02-25 | 1965-04-27 | Benedict David | Machines for cutting lengths of strip material |
CU22545A1 (en) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE |
US5286647A (en) | 1982-05-21 | 1994-02-15 | University Of California | Human-human hybridomas for neoplasms |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
DE3631229A1 (en) * | 1986-09-13 | 1988-03-24 | Basf Ag | MONOCLONAL ANTIBODIES AGAINST HUMAN TUMORNESCROSE FACTOR (TNF) AND THEIR USE |
US4950599A (en) | 1987-01-29 | 1990-08-21 | Wolf Bertling | Method for exchanging homologous DNA sequences in a cell using polyoma encapsulated DNA fragments |
FR2637613B1 (en) | 1987-06-19 | 1991-09-27 | Transgene Sa | PROCESS FOR THE PREPARATION OF STABLE CELL LINES FOR THE PRODUCTION OF DETERMINED PROTEINS FROM TRANSGENIC ANIMALS; TUMOR CELL LINES AND PROTEINS OBTAINED |
US4959313A (en) | 1987-06-22 | 1990-09-25 | The Jackson Laboratory | Cellular enhancer for expressing genes in undifferentiated stem cells |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
DE3853201T2 (en) | 1987-12-23 | 1995-09-14 | Univ Leland Stanford Junior | Chimeric immunocompromising mammals and their use. |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
ATE139258T1 (en) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | GENERATION OF XENOGENE ANTIBODIES |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
JP3008208B2 (en) | 1990-06-01 | 2000-02-14 | 武田薬品工業株式会社 | Novel hybridoma, its production method and production method of bioactive substance |
FR2664073A1 (en) | 1990-06-29 | 1992-01-03 | Thomson Csf | MEANS FOR MARKING OBJECTS, METHOD FOR PRODUCING THE SAME, AND DEVICE FOR READING. |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
KR100272077B1 (en) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
ATE247168T1 (en) | 1991-03-06 | 2003-08-15 | Merck Patent Gmbh | HUMANIZED MONOCLONAL ANTIBODIES |
US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
WO1992022645A1 (en) | 1991-06-14 | 1992-12-23 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
GB9119338D0 (en) | 1991-09-10 | 1991-10-23 | Inst Of Animal Physiology And | Control of gene expression |
AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
AU4541093A (en) | 1992-06-18 | 1994-01-24 | Genpharm International, Inc. | Methods for producing transgenic non-human animals harboring a yeast artificial chromosome |
SG48760A1 (en) | 1992-07-24 | 2003-03-18 | Abgenix Inc | Generation of xenogenetic antibodies |
ATE204299T1 (en) * | 1993-03-05 | 2001-09-15 | Bayer Ag | HUMAN MONOCLONAL ANTI-TNF ALPHA ANTIBODIES |
US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
WO1995023865A1 (en) | 1994-03-03 | 1995-09-08 | Genentech, Inc. | Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders |
HU221001B1 (en) * | 1994-03-17 | 2002-07-29 | Merck Patent Gmbh. | Anti-egfr single-chain fvs, anti-egfr antibodies |
EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
CA2273194C (en) | 1996-12-03 | 2011-02-01 | Abgenix, Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
TWI255853B (en) | 1998-08-21 | 2006-06-01 | Kirin Brewery | Method for modifying chromosomes |
GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
KR100770065B1 (en) | 2001-05-11 | 2007-10-24 | 기린 파마 가부시끼가이샤 | Artificial Human Chromosome Containing Human Antibody ? Light Chain Gene |
US8359965B2 (en) | 2007-09-17 | 2013-01-29 | Oxford J Craig | Apparatus and method for broad spectrum radiation attenuation |
IL226488A (en) | 2013-05-21 | 2016-07-31 | Aspect Imaging Ltd | Cradle for neonates |
JP6071725B2 (en) | 2013-04-23 | 2017-02-01 | カルソニックカンセイ株式会社 | Driving force control device for electric vehicles |
US9605925B1 (en) | 2015-03-12 | 2017-03-28 | Josh M. McRoberts | Bump fire grip |
US11284893B2 (en) | 2019-04-02 | 2022-03-29 | Covidien Lp | Stapling device with articulating tool assembly |
-
1997
- 1997-12-03 CA CA2273194A patent/CA2273194C/en not_active Expired - Lifetime
- 1997-12-03 AT AT04013481T patent/ATE549918T1/en active
- 1997-12-03 EP EP08003509A patent/EP1972194A1/en not_active Withdrawn
- 1997-12-03 PT PT97953227T patent/PT942968E/en unknown
- 1997-12-03 PT PT04013481T patent/PT1500329E/en unknown
- 1997-12-03 KR KR1019997004855A patent/KR100643058B1/en not_active IP Right Cessation
- 1997-12-03 CA CA2722378A patent/CA2722378C/en not_active Expired - Lifetime
- 1997-12-03 AU AU57022/98A patent/AU5702298A/en not_active Abandoned
- 1997-12-03 DK DK04013481.9T patent/DK1500329T3/en active
- 1997-12-03 AT AT97953227T patent/ATE387495T1/en active
- 1997-12-03 KR KR1020057002900A patent/KR100942002B1/en not_active IP Right Cessation
- 1997-12-03 KR KR1020087012502A patent/KR20080059467A/en not_active Application Discontinuation
- 1997-12-03 DK DK97953227T patent/DK0942968T3/en active
- 1997-12-03 CA CA2616914A patent/CA2616914C/en not_active Expired - Fee Related
- 1997-12-03 ES ES04013481T patent/ES2384942T3/en not_active Expired - Lifetime
- 1997-12-03 DE DE69738539T patent/DE69738539T2/en not_active Expired - Lifetime
- 1997-12-03 JP JP52590998A patent/JP4215172B2/en not_active Expired - Lifetime
- 1997-12-03 EP EP97953227A patent/EP0942968B1/en not_active Expired - Lifetime
- 1997-12-03 WO PCT/US1997/023091 patent/WO1998024893A2/en active IP Right Grant
- 1997-12-03 ES ES97953227T patent/ES2301183T3/en not_active Expired - Lifetime
- 1997-12-03 EP EP04013481A patent/EP1500329B1/en not_active Expired - Lifetime
- 1997-12-03 EP EP10182935.6A patent/EP2314625B1/en not_active Expired - Lifetime
- 1997-12-03 EP EP10182932.3A patent/EP2305027B1/en not_active Expired - Lifetime
-
2000
- 2000-03-17 HK HK00101647A patent/HK1022720A1/en not_active IP Right Cessation
- 2000-03-17 HK HK05106153.5A patent/HK1074348A1/en not_active IP Right Cessation
-
2002
- 2002-02-19 US US10/078,958 patent/US7064244B2/en not_active Expired - Fee Related
-
2005
- 2005-01-28 JP JP2005021414A patent/JP4808412B2/en not_active Expired - Lifetime
- 2005-10-14 US US11/250,805 patent/US7820877B2/en not_active Expired - Fee Related
-
2007
- 2007-08-20 US US11/894,779 patent/US8809051B2/en not_active Expired - Fee Related
-
2008
- 2008-05-12 JP JP2008124406A patent/JP2008194058A/en not_active Withdrawn
- 2008-05-21 JP JP2008132621A patent/JP4195077B1/en not_active Expired - Lifetime
-
2011
- 2011-06-30 JP JP2011146571A patent/JP2011212019A/en not_active Withdrawn
-
2014
- 2014-08-18 US US14/462,499 patent/US20150250152A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991000906A1 (en) * | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
WO1994025585A1 (en) * | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1996034096A1 (en) * | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
Non-Patent Citations (7)
Title |
---|
A. JAKOBOVITS ET AL., : "Human immunity in mice engineered with megabase human heavy and kappa light chain YACs" THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 99, no. 1, part 2, 1 January 1997, SAINT LOUIS, MO, US, page S113 XP002067604 * |
A. JAKOBOVITS ET AL., : "Production of antigen-specific human antibodies from mice engineered with human heavy and light chain YACs" ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 764, 1995, NEW YORK, NY, US, pages 525-535, XP002067728 * |
J.R.F. CORVALAN ET AL., : "Generation of fully human high affinity monoclonal antibodies to EGF receptor in mice" THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 99, no. 1, part 2, 1 January 1997, SAINT LOUIS, MO, US, page s214 XP002067605 * |
L.D. TAYLOR ET AL.,: "A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins" NUCLEIC ACIDS RESEARCH, vol. 20, no. 23, 1992, OXFROD, GB, pages 6287-6295, XP002041128 cited in the application * |
M. BRUGGEMAN AND N.S. NEUBERGER: "Strategies for expressing human antibody repertoires in transgenic mice" IMMUNOLOGY TODAY, vol. 17, no. 8, 1 August 1996, OXFORD, GB, pages 391-397, XP002067729 cited in the application * |
M.J. MENDEZ: "Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice" NATURE GENETICS, vol. 15, no. 2, 1 February 1997, NEW YORK, NY, US, pages 146-156, XP002067603 * |
X.D. YANG ET AL.,: "Human monoclonal antibodies to human TNF-alpha generated from mice carrying human Ig loci" THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 99, no. 1, part 2, 1 January 1997, SAINT LOUIS, MO, US, page s15 XP002067606 * |
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---|---|---|---|---|
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US8158419B2 (en) | 1994-03-09 | 2012-04-17 | Medarex, Inc. | Transgenic non-human animals for producing chimeric antibodies |
US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
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US8809051B2 (en) | 1996-12-03 | 2014-08-19 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vκ regions and antibodies produced therefrom |
US7820877B2 (en) | 1996-12-03 | 2010-10-26 | Amgen Fremont Inc. | Transgenic mammals having human IG loci including plural Vh and Vk regions and antibodies produced therefrom |
WO1998050433A2 (en) * | 1997-05-05 | 1998-11-12 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US7807798B2 (en) | 1997-05-05 | 2010-10-05 | Amgen Fremont Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
EP1878746A3 (en) * | 1997-05-05 | 2011-05-25 | Amgen Fremont Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
WO1998050433A3 (en) * | 1997-05-05 | 1999-02-04 | Abgenix Inc | Human monoclonal antibodies to epidermal growth factor receptor |
US8227580B2 (en) | 1997-05-05 | 2012-07-24 | Amgen Inc | Human monoclonal antibodies to epidermal growth factor receptor |
EP1854885A2 (en) | 1997-11-21 | 2007-11-14 | Serono Genetics Institute S.A. | Chlamydia pneumoniae genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
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WO2000026373A1 (en) * | 1998-11-03 | 2000-05-11 | Babraham Institute | MURINE EXPRESSION OF HUMAN Igμ LOCUS |
US6998514B2 (en) | 1998-11-03 | 2006-02-14 | Babraham Institute | Murine expression of a human IgA lambda locus |
US9963508B2 (en) | 1998-12-23 | 2018-05-08 | Amgen Fremont Inc. | Human monoclonal antibodies to CTLA-4 |
US8143379B2 (en) | 1998-12-23 | 2012-03-27 | Amgen Fremont Inc. | Human monoclonal antibodies to CTLA-4 |
US7132281B2 (en) | 1998-12-23 | 2006-11-07 | Amgen Fremont Inc. | Methods and host cells for producing human monoclonal antibodies to CTLA-4 |
US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
US7411057B2 (en) | 1998-12-23 | 2008-08-12 | Amgen Fremont Inc. | Nucleic acids encoding human monoclonal antibodies to CTLA-4 |
US7807797B2 (en) | 1998-12-23 | 2010-10-05 | Amgen Fremont Inc. | Human monoclonal antibodies to CTLA-4 |
US7824679B2 (en) | 1998-12-23 | 2010-11-02 | Amgen Fremont Inc. | Human monoclonal antibodies to CTLA-4 |
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US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
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WO2000076310A1 (en) * | 1999-06-10 | 2000-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
US7547817B2 (en) | 1999-06-10 | 2009-06-16 | Amgen Fremont Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
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US6984720B1 (en) | 1999-08-24 | 2006-01-10 | Medarex, Inc. | Human CTLA-4 antibodies |
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WO2001019394A3 (en) * | 1999-09-15 | 2001-10-04 | Therapeutic Human Polyclonals | Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds |
EP2003202A2 (en) | 1999-10-05 | 2008-12-17 | Agensys, Inc. | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
US7771968B2 (en) | 1999-10-28 | 2010-08-10 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
US7928212B2 (en) | 1999-10-28 | 2011-04-19 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
US6893818B1 (en) | 1999-10-28 | 2005-05-17 | Agensys, Inc. | Gene upregulated in cancers of the prostate |
EP2194130A1 (en) | 1999-12-23 | 2010-06-09 | ZymoGenetics, L.L.C. | Cytokine ZCYTO18 |
US7767207B2 (en) | 2000-02-10 | 2010-08-03 | Abbott Laboratories | Antibodies that bind IL-18 and methods of inhibiting IL-18 activity |
WO2001077361A1 (en) * | 2000-04-10 | 2001-10-18 | American Biogenetic Sciences, Inc. | Human immunoglobulin-producing gnotobiotics |
EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
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WO2002002641A1 (en) | 2000-06-16 | 2002-01-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
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EP2022797A2 (en) | 2000-08-28 | 2009-02-11 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer |
US8791323B2 (en) | 2000-10-31 | 2014-07-29 | Regeneron Pharmaceuticals, Inc. | Hybrid antibodies comprising human variable regions and mouse constant regions produced in a genetically modified mouse |
US9376699B2 (en) | 2000-10-31 | 2016-06-28 | Regeneron Pharmaceuticals, Inc. | Methods of producing hybrid antibodies |
US9708635B2 (en) | 2000-10-31 | 2017-07-18 | Regeneron Pharmaceuticals, Inc. | Methods of making a nucleic acid encoding a human variable region |
US10344299B2 (en) | 2000-10-31 | 2019-07-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for modifying cells |
US8759105B2 (en) | 2000-10-31 | 2014-06-24 | Regeneron Pharmaceuticals, Inc. | Method for genetically modifying mouse embryonic stem cell by homologous recombination |
US8846402B2 (en) | 2000-10-31 | 2014-09-30 | Regeneron Pharmaceuticals, Inc. | Method for genetically modifying isolated non-human mammalian cell by homologous recombination |
US9677129B2 (en) | 2000-10-31 | 2017-06-13 | Regeneron Pharmaceuticals, Inc. | Method for detecting the replacement of an endogenous allele with a modified allele by homologous recombination in a mouse ES cell |
US10227625B2 (en) | 2000-10-31 | 2019-03-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
EP2042594A1 (en) | 2000-11-17 | 2009-04-01 | Kirin Pharma Kabushiki Kaisha | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
EP2338512A1 (en) | 2000-11-28 | 2011-06-29 | MedImmune, LLC | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
EP2027874A2 (en) | 2000-11-28 | 2009-02-25 | Medimmune, Inc. | Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment |
EP2412384A1 (en) | 2000-11-28 | 2012-02-01 | MedImmune, LLC | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
EP2339035A1 (en) | 2000-12-07 | 2011-06-29 | Novartis Vaccines and Diagnostics, Inc. | Endogenous retroviruses up-regulated in prostate cancer |
US10584364B2 (en) | 2000-12-07 | 2020-03-10 | Rgeneron Pharmaceuticals, Inc. | Mice that produce hybrid antibodies |
EP2336368A1 (en) | 2000-12-07 | 2011-06-22 | Novartis Vaccines and Diagnostics, Inc. | Endogenous retroviruses up-regulated in prostate cancer |
US7776523B2 (en) | 2000-12-07 | 2010-08-17 | Novartis Vaccines And Diagnostics, Inc. | Endogenous retroviruses up-regulated in prostate cancer |
EP2354149A1 (en) | 2000-12-12 | 2011-08-10 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
EP2341060A1 (en) | 2000-12-12 | 2011-07-06 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
EP2357187A1 (en) | 2000-12-12 | 2011-08-17 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
EP3569610A2 (en) | 2000-12-12 | 2019-11-20 | Medlmmune, LLC | Molecules with extended half lives, compositions and uses thereof |
WO2002059263A3 (en) * | 2000-12-19 | 2004-02-26 | Sunol Molecular Corp | Transgenic animals comprising a humanized immune system |
EP2194067A2 (en) | 2001-01-05 | 2010-06-09 | Pfizer Inc. | Antibodies to insulin-like growth factor I receptor (IGF-IR) |
US7037498B2 (en) | 2001-01-05 | 2006-05-02 | Abgenix, Inc. | Antibodies to insulin-like growth factor I receptor |
EP2796468A2 (en) | 2001-01-05 | 2014-10-29 | Pfizer Inc | Antibodies to insulin-like growth factor I receptor |
WO2002064612A2 (en) | 2001-02-09 | 2002-08-22 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (ccr5) hdgnr10 |
US10378037B2 (en) | 2001-02-16 | 2019-08-13 | Regeneron Pharmaceuticals, Inc. | Methods of making a nucleic acid encoding a human variable region |
US9528136B2 (en) | 2001-02-16 | 2016-12-27 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
EP2264163A2 (en) | 2001-02-16 | 2010-12-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
EP2786657B1 (en) | 2001-02-16 | 2018-02-07 | Regeneron Pharmaceuticals, Inc. | A method of producing an antibody comprising a human variable region and a rodent constant region. |
US9371553B2 (en) | 2001-02-16 | 2016-06-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice that produce hybrid antibodies |
EP2767588B1 (en) * | 2001-02-16 | 2020-08-19 | Regeneron Pharmaceuticals, Inc. | Use of mouse producing hybrid antibodies containing human variable regions and mouse constant regions as a source of dna encoding a human variable region of a said antibody |
US10378039B2 (en) | 2001-02-16 | 2019-08-13 | Regeneron Pharmaceuticals, Inc. | Mouse embryonic stem cells comprising a hybrid heavy chain immunoglobulin locus |
US10378038B2 (en) | 2001-02-16 | 2019-08-13 | Regeneron Pharmaceuticals, Inc. | Mice that produce hybrid antibodies |
US20140017238A1 (en) | 2001-02-16 | 2014-01-16 | Regeneron Pharmaceuticals, Inc. | Methods of Modifying Eukaryotic Cells |
US9382567B2 (en) | 2001-02-16 | 2016-07-05 | Regeneron Pharmaceuticals, Inc. | Methods of producing hybrid antibodies |
US10526630B2 (en) | 2001-02-16 | 2020-01-07 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice that produce hybrid antibodies |
US9353394B2 (en) | 2001-02-16 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Methods of producing hybrid antibodies |
US10378040B2 (en) | 2001-02-16 | 2019-08-13 | Regeneron Pharmaceuticals, Inc. | Mice that produce hybrid antibodies |
US10640800B2 (en) | 2001-02-16 | 2020-05-05 | Regeneron Pharmaceuticals, Inc. | Mice that produce hybrid antibodies |
US9388446B2 (en) | 2001-02-16 | 2016-07-12 | Regeneron Pharmaceuticals, Inc. | Methods of producing hybrid antibodies |
EP2311863A1 (en) | 2001-03-05 | 2011-04-20 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer |
EP2366711A2 (en) | 2001-03-14 | 2011-09-21 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer |
WO2002072785A2 (en) | 2001-03-14 | 2002-09-19 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 125p5c8 useful in treatment and detection of cancer |
US8981061B2 (en) | 2001-03-20 | 2015-03-17 | Novo Nordisk A/S | Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
EP2294917A1 (en) | 2001-03-22 | 2011-03-16 | Abbott GmbH & Co. KG | Transgenic animals expressing antibodies specific for genes of interest and uses thereof |
US7795494B2 (en) | 2001-03-22 | 2010-09-14 | Abbott Laboratories | Transgenic mice expressing antibodies specific for genes of interest and uses thereof |
US7351811B2 (en) | 2001-04-06 | 2008-04-01 | Georgetown University | Gene SCC-112 and diagnostic and therapeutic uses thereof |
EP2280030A2 (en) | 2001-04-10 | 2011-02-02 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
EP2228389A2 (en) | 2001-04-13 | 2010-09-15 | Human Genome Sciences, Inc. | Antibodies against vascular endothelial growth factor 2 |
US7078492B2 (en) | 2001-05-16 | 2006-07-18 | Abgenix, Inc. | Human antipneumococcal antibodies from non-human animals |
WO2002097033A2 (en) | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
EP2080766A1 (en) | 2001-06-06 | 2009-07-22 | Bristol-Myers Squibb Company | B7-related nucleic acids and polypeptides useful for immunomodulation |
EP3492100A1 (en) | 2001-06-26 | 2019-06-05 | Amgen Inc. | Antibodies to opgl |
EP2087908A1 (en) | 2001-06-26 | 2009-08-12 | Amgen, Inc. | Antibodies to opgl |
EP2287186A1 (en) | 2001-09-06 | 2011-02-23 | Agensys, Inc. | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
EP2302041A1 (en) | 2001-11-07 | 2011-03-30 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
EP2343086A2 (en) | 2001-11-09 | 2011-07-13 | Pfizer Products Inc. | Antibodies to CD40 |
JP2013198489A (en) * | 2001-11-30 | 2013-10-03 | Amgen Fremont Inc | TRANSGENIC ANIMAL BEARING HUMAN Igλ LIGHT CHAIN GENE |
EP1461442B1 (en) * | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
WO2003047336A2 (en) | 2001-11-30 | 2003-06-12 | Abgenix, Inc. | TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES |
US7435871B2 (en) | 2001-11-30 | 2008-10-14 | Amgen Fremont Inc. | Transgenic animals bearing human Igλ light chain genes |
EP3698626A1 (en) | 2001-11-30 | 2020-08-26 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
EP2319301A3 (en) * | 2001-11-30 | 2011-06-29 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
EP2319301B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
EP3269235A1 (en) | 2001-11-30 | 2018-01-17 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
EP2319301A2 (en) | 2001-11-30 | 2011-05-11 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
JP2009100765A (en) * | 2001-11-30 | 2009-05-14 | Amgen Fremont Inc | TRANSGENIC ANIMAL BEARING HUMAN Iglambda LIGHT CHAIN GENE |
EP2277888A2 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Fusion proteins of albumin and erythropoietin |
EP2990417A1 (en) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Albumin insulin fusion protein |
EP1997829A1 (en) | 2001-12-21 | 2008-12-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2261250A1 (en) | 2001-12-21 | 2010-12-15 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2277889A2 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Fusion proteins of albumin and interferon beta |
EP2277910A1 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7067131B2 (en) | 2001-12-28 | 2006-06-27 | Abgenix, Inc. | Methods for using anti-MUC18 antibodies |
US7090844B2 (en) | 2001-12-28 | 2006-08-15 | Abgenix, Inc. | Use of antibodies against the MUC18 antigen |
EP1572900A2 (en) * | 2002-01-07 | 2005-09-14 | Abgenix, Inc. | Antibodies directed to pdgfd and uses thereof |
EP1572900A4 (en) * | 2002-01-07 | 2007-01-03 | Abgenix Inc | Antibodies directed to pdgfd and uses thereof |
US8088377B2 (en) | 2002-01-09 | 2012-01-03 | Medarex, Inc. | Human monoclonal antibodies against CD30 |
EP2338910A1 (en) | 2002-01-18 | 2011-06-29 | ZymoGenetics, Inc. | Cytokine receptor Zcytor17 multimers |
EP2840089A1 (en) | 2002-01-18 | 2015-02-25 | ZymoGenetics, Inc. | Cytokine receptor zcytor17 multimers |
EP2230299A1 (en) | 2002-01-18 | 2010-09-22 | ZymoGenetics, Inc. | Novel cytokine ZCYTOR17 ligand |
US8673305B2 (en) | 2002-01-25 | 2014-03-18 | G2 Therapies Ltd | Methods of treatment with antibodies against the extracellular loops of C5aR |
EP2093233A1 (en) | 2002-03-21 | 2009-08-26 | Sagres Discovery, Inc. | Novel compositions and methods in cancer |
US7141653B2 (en) | 2002-03-29 | 2006-11-28 | Schering Corporation | Human monoclonal antibodies to interleukin-5 |
US7422742B2 (en) | 2002-03-29 | 2008-09-09 | Schering Corporation | Methods for using human monoclonal antibodies to interleukin-5 |
EP2314316A1 (en) | 2002-04-05 | 2011-04-27 | Amgen, Inc | Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors |
US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
US8586717B2 (en) | 2002-04-08 | 2013-11-19 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
US8029784B2 (en) | 2002-04-08 | 2011-10-04 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
US7244565B2 (en) | 2002-04-10 | 2007-07-17 | Georgetown University | Gene shinc-3 and diagnostic and therapeutic uses thereof |
US8142778B2 (en) | 2002-04-12 | 2012-03-27 | Medarex, Inc. | Methods of treatment using CTLA-4 antibodies |
EP2270049A2 (en) | 2002-04-12 | 2011-01-05 | Medimmune, Inc. | Recombinant anti-interleukin-9-antibody |
US7452535B2 (en) | 2002-04-12 | 2008-11-18 | Medarex, Inc. | Methods of treatment using CTLA-4 antibodies |
WO2003086458A1 (en) | 2002-04-12 | 2003-10-23 | Medimmune, Inc. | Recombinant anti-interleukin-9 antibodies |
WO2003087374A1 (en) | 2002-04-18 | 2003-10-23 | Yeda Research And Development Co. Ltd. | Derivatives of the il-2 receptor gamma chain, their production and use. |
WO2003089603A2 (en) | 2002-04-19 | 2003-10-30 | Zymogenetics, Inc. | Cytokine receptor |
EP2295455A1 (en) | 2002-04-19 | 2011-03-16 | ZymoGenetics, L.L.C. | Cytokine receptor |
WO2003097812A2 (en) | 2002-05-17 | 2003-11-27 | Hematech, Llc | Transgenic ungulates capable of human antibody production |
US7879990B2 (en) | 2002-06-10 | 2011-02-01 | University Of Rochester | Polynucleotides encoding antibodies that bind to the C35 polypeptide |
US7968688B2 (en) | 2002-06-10 | 2011-06-28 | University Of Rochester | Antibodies that bind to the C35 polypeptide |
US7750125B2 (en) | 2002-06-10 | 2010-07-06 | University Of Rochester | Antibodies that bind to the C35 polypeptide |
US8518694B2 (en) | 2002-06-13 | 2013-08-27 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acid vector comprising a promoter and a sequence encoding a polypeptide from the endogenous retrovirus PCAV |
EP2570432A1 (en) | 2002-06-14 | 2013-03-20 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
US10934571B2 (en) | 2002-07-18 | 2021-03-02 | Merus N.V. | Recombinant production of mixtures of antibodies |
EP2371389A2 (en) | 2002-08-14 | 2011-10-05 | MacroGenics, Inc. | FcgammaRIIB-specific antibodies and methods of use thereof |
EP2301954A2 (en) | 2002-08-16 | 2011-03-30 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 282P1G3 useful in treatment and detection of cancer |
EP2332966A1 (en) | 2002-08-16 | 2011-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 191P4D12(b) useful in treatment and detection of cancer |
EP3020414A1 (en) | 2002-09-06 | 2016-05-18 | Amgen, Inc | Therapeutic anti-il-1r1 monoclonal antibody |
EP2213685A1 (en) | 2002-09-06 | 2010-08-04 | Amgen Inc. | Therapeutic anti-IL-1R1 monoclonal antibody |
EP2277543A1 (en) | 2002-09-06 | 2011-01-26 | Amgen, Inc | Therapeutic anti-IL-1R1 monoclonal antibody |
EP2298811A2 (en) | 2002-10-16 | 2011-03-23 | Amgen Inc. | Human anti-ifn-gamma neutralizing antibodies as selective ifn-gamma pathway inhibitors |
WO2004035747A2 (en) | 2002-10-16 | 2004-04-29 | Amgen Inc. | Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors |
US7807863B2 (en) | 2002-11-08 | 2010-10-05 | Kyowa Hakko Kirin Co., Ltd. | Transgenic bovine having reduced prion protein activity and uses thereof |
EP2246363A1 (en) | 2002-11-15 | 2010-11-03 | Novartis Vaccines and Diagnostics, Inc. | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
EP2287192A1 (en) | 2002-11-15 | 2011-02-23 | Novartis Vaccines and Diagnostics, Inc. | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
US8101178B2 (en) | 2002-12-02 | 2012-01-24 | Amgen Fremont Inc. | Antibodies directed to tumor necrosis factor and uses thereof |
WO2004050683A2 (en) | 2002-12-02 | 2004-06-17 | Abgenix, Inc. | Antibodies directed to tumor necrosis factor and uses thereof |
WO2004058171A2 (en) | 2002-12-20 | 2004-07-15 | Protein Design Labs, Inc. | Antibodies against gpr64 and uses thereof |
EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
EP2336160A2 (en) | 2003-01-31 | 2011-06-22 | Abbott GmbH & Co. KG | Amyloid-beta(1-42) oligomers, derivatives thereof, antibodies for the same, method for production and use thereof. |
US10464976B2 (en) | 2003-01-31 | 2019-11-05 | AbbVie Deutschland GmbH & Co. KG | Amyloid β(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
EP2336159A2 (en) | 2003-01-31 | 2011-06-22 | Abbott GmbH & Co. KG | Amyloid-beta(1-42) oligomers, derivatives thereof, antibodies for the same, method for production and use thereof. |
EP2336161A2 (en) | 2003-01-31 | 2011-06-22 | Abbott GmbH & Co. KG | Amyloid-beta(1-42) oligomers, derivatives thereof, antibodies for the same, method for production and use thereof. |
EP2343315A2 (en) | 2003-02-10 | 2011-07-13 | Agensys, Inc. | Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers |
EP2241330A1 (en) | 2003-02-14 | 2010-10-20 | The Curators Of The University Of Missouri | Contraceptive methods and compositions related to proteasomal interference |
EP2058408A2 (en) | 2003-02-14 | 2009-05-13 | Sagres Discovery, Inc. | Therapeutic GPCR targets in cancer |
WO2004073656A2 (en) | 2003-02-20 | 2004-09-02 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
EP2289559A1 (en) | 2003-02-20 | 2011-03-02 | Seattle Genetics, Inc. | Anit-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
EP2100619A1 (en) | 2003-02-20 | 2009-09-16 | Seattle Genetics, Inc. | Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
US8932821B2 (en) | 2003-03-19 | 2015-01-13 | Biogen Idec Ma Inc. | NOGO receptor binding protein |
EP3000886A1 (en) | 2003-03-19 | 2016-03-30 | Amgen Fremont Inc. | Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof |
US8765662B2 (en) | 2003-03-19 | 2014-07-01 | Biogen Idec Ma Inc. | NOGO receptor binding protein |
WO2004084823A2 (en) | 2003-03-19 | 2004-10-07 | Abgenix, Inc. | Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof |
US7785829B2 (en) | 2003-03-19 | 2010-08-31 | Biogen Idec Ma, Inc. | Nogo receptor binding protein |
EP2316487A1 (en) | 2003-04-11 | 2011-05-04 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
US8404820B2 (en) | 2003-05-21 | 2013-03-26 | Medarex, Inc. | Human monoclonal antibodies against Bacillus anthracis protective antigen |
US9738701B2 (en) | 2003-05-30 | 2017-08-22 | Merus N.V. | Method for selecting a single cell expressing a heterogeneous combination of antibodies |
US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
US10670599B2 (en) | 2003-05-30 | 2020-06-02 | Merus N.V. | Method for selecting a single cell expressing a heterogeneous combination of antibodies |
EP2319524A1 (en) | 2003-05-30 | 2011-05-11 | Agensys, Inc. | Prostate stem cell antigen (PSCA) variants and subsequences thereof |
US11492411B2 (en) | 2003-06-27 | 2022-11-08 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US7628986B2 (en) | 2003-06-27 | 2009-12-08 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP2457586A1 (en) | 2003-06-27 | 2012-05-30 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US10508153B2 (en) | 2003-06-27 | 2019-12-17 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP3037105A1 (en) | 2003-06-27 | 2016-06-29 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US9096672B2 (en) | 2003-06-27 | 2015-08-04 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP2457587A1 (en) | 2003-06-27 | 2012-05-30 | Amgen Fremont Inc. | Anitbodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US9085624B2 (en) | 2003-06-27 | 2015-07-21 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP3679951A1 (en) | 2003-06-27 | 2020-07-15 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US9062113B2 (en) | 2003-06-27 | 2015-06-23 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US7736644B2 (en) | 2003-06-27 | 2010-06-15 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP3011971A1 (en) | 2003-06-27 | 2016-04-27 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US10118968B2 (en) | 2003-06-27 | 2018-11-06 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US9073998B2 (en) | 2003-06-27 | 2015-07-07 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
US7393534B2 (en) | 2003-07-15 | 2008-07-01 | Barros Research Institute | Compositions and methods for immunotherapy of cancer and infectious diseases |
US8257714B2 (en) | 2003-07-15 | 2012-09-04 | Michigan State University | Compositions and methods for immunotherapy of cancer and infectious diseases |
EP2341067A1 (en) | 2003-07-18 | 2011-07-06 | Amgen, Inc | Specific binding agents to hepatocyte growth factor |
WO2005016111A2 (en) | 2003-08-08 | 2005-02-24 | Abgenix, Inc. | Antibodies directed to parathyroid hormone (pth) and uses thereof |
EP2128270A1 (en) | 2003-08-08 | 2009-12-02 | Genenews Inc. | Osteoarthritis biomarkers and uses thereof |
WO2005019463A1 (en) * | 2003-08-11 | 2005-03-03 | Therapeutic Human Polyclonals, Inc. | Improved transgenesis with humanized immunoglobulin loci |
US20080254021A1 (en) * | 2003-08-12 | 2008-10-16 | Dyax Corp. | Tie1-binding ligands |
NO343557B1 (en) * | 2003-09-10 | 2019-04-01 | Warner Lambert Co | Antibodies to M-CSF |
NL1027009C2 (en) * | 2003-09-10 | 2006-06-19 | Warner Lambert Co | Antibodies to M-CSF. |
EP3170840A1 (en) | 2003-09-10 | 2017-05-24 | Warner-Lambert Company LLC | Antibodies to m-csf |
US9718883B2 (en) | 2003-09-10 | 2017-08-01 | Amgen Fremont Inc. | Antibodies to M-CSF |
US10280219B2 (en) | 2003-09-10 | 2019-05-07 | Amgen Fremont Inc. | Antibodies to M-CSF |
EP1670825A4 (en) * | 2003-09-10 | 2012-01-18 | Warner Lambert Co | Antibodies to m-csf |
EP1670825A2 (en) * | 2003-09-10 | 2006-06-21 | Warner-Lambert Company | Antibodies to m-csf |
EP2322561A1 (en) | 2003-10-07 | 2011-05-18 | Yeda Research And Development Co., Ltd. | Anti-NIK antibodies and uses thereof |
EP2354164A1 (en) | 2003-10-07 | 2011-08-10 | Yeda Research And Development Co., Ltd. | Anti-NIK antibodies and uses thereof |
EP2395020A2 (en) | 2003-11-12 | 2011-12-14 | Abbott Laboratories | IL-18 binding proteins |
EP2460829A2 (en) | 2003-11-12 | 2012-06-06 | Abbott Laboratories | IL-18 binding proteins |
EP2460830A2 (en) | 2003-11-12 | 2012-06-06 | Abbott Laboratories | IL-18 binding proteins |
EP2385070A1 (en) | 2003-11-12 | 2011-11-09 | Abbott Laboratories | Il-18 binding proteins |
EP2805728A1 (en) | 2003-12-23 | 2014-11-26 | Genentech, Inc. | Novel anti-IL 13 antibodies and uses thereof |
EP3718564A1 (en) | 2003-12-23 | 2020-10-07 | Genentech, Inc. | Novel anti-il 13 antibodies and uses thereof |
WO2005062972A2 (en) | 2003-12-23 | 2005-07-14 | Tanox, Inc. | Treatment of cancer with novel anti-il 13 monoclonal antibodies |
EP2332575A1 (en) | 2003-12-23 | 2011-06-15 | Genentech, Inc. | Treatment of cancer with novel anti-IL 13 monoclonal antibodies |
EP2351584A1 (en) | 2003-12-23 | 2011-08-03 | Genentech, Inc. | Novel anti-IL 13 antibodies and uses thereof |
WO2005060739A1 (en) * | 2003-12-24 | 2005-07-07 | G2 Inflammation Pty Ltd | Transgenic non-human mammal comprising a polynucleotide encoding human or humanized c5ar |
US8071839B2 (en) | 2003-12-24 | 2011-12-06 | G2 Inflammation Pty Ltd | Transgenic mouse comprising a polynucleotide encoding human or humanized C5aR and methods of production and use |
US9926371B2 (en) | 2004-01-07 | 2018-03-27 | Novartis Vaccines And Diagnostics, Inc. | M-CSF specific monoclonal antibody and uses thereof |
EP2311873A1 (en) | 2004-01-07 | 2011-04-20 | Novartis Vaccines and Diagnostics, Inc. | M-CSF-specific monoclonal antibody and uses thereof |
US11034759B2 (en) | 2004-01-07 | 2021-06-15 | Novartis Vaccines And Diagnostics, Inc. | Humanized M-CSF specific monoclonal antibodies, kits, and uses thereof |
EP3476861A1 (en) | 2004-01-07 | 2019-05-01 | Novartis Vaccines and Diagnostics, Inc. | M-csf-specific monoclonal antibody and uses thereof |
US9522186B2 (en) | 2004-01-07 | 2016-12-20 | Novartis Vaccines And Diagnostics Inc. | M-CSF specific monoclonal antibody and uses therof |
US9079956B2 (en) | 2004-01-07 | 2015-07-14 | Novartis Vaccines And Diagnostics Inc. | M-CSF specific monoclonal antibody and uses thereof |
US10259872B2 (en) | 2004-01-09 | 2019-04-16 | Pfizer, Inc. | Antibodies to MAdCAM |
USRE45847E1 (en) | 2004-01-09 | 2016-01-19 | Pfizer Inc. | Antibodies to MAdCAM |
US9328169B2 (en) | 2004-01-09 | 2016-05-03 | Pfizer Inc. | Human antibodies that bind human MAdCAM |
US7932372B2 (en) | 2004-01-09 | 2011-04-26 | Amgen Fremont Inc. | Antibodies to MAdCAM |
WO2005077042A2 (en) | 2004-02-09 | 2005-08-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2005092926A2 (en) | 2004-03-19 | 2005-10-06 | Amgen Inc. | Reducing the risk of human and anti-human antibodies through v gene manipulation |
EP2418224A2 (en) | 2004-03-19 | 2012-02-15 | Amgen Inc. | Reducing the risk of human and anti-human antibodies through V gene manipulation |
US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
US8198508B2 (en) | 2004-03-19 | 2012-06-12 | Amgen Fremont, Inc. | Reducing the risk of human anti-human antibodies through V gene manipulation |
US8597615B2 (en) | 2004-03-19 | 2013-12-03 | Amgen Fremont Inc. | Methods of monitoring a human anti-human antibody response and inhibitors thereof |
WO2005117967A2 (en) | 2004-04-12 | 2005-12-15 | Medimmune, Inc. | Anti-il-9 antibody formulations and uses thereof |
US7928285B2 (en) | 2004-04-22 | 2011-04-19 | Kyowa Hakko Kirin Co., Ltd. | Method of producing xenogenous antibodies using a bovine |
WO2005118864A2 (en) | 2004-05-28 | 2005-12-15 | Agensys, Inc. | Antibodies and related molecules that bind to psca proteins |
EP2428522A1 (en) | 2004-05-28 | 2012-03-14 | Agensys, Inc. | Antibodies that bind to PSCA proteins for diagnosis of cancer |
EP2583981A2 (en) | 2004-05-28 | 2013-04-24 | Agensys, Inc. | Antibodies and related molecules that bind to PSCA proteins |
EP2740743A2 (en) | 2004-06-01 | 2014-06-11 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
EP2497492A1 (en) | 2004-06-01 | 2012-09-12 | Mount Sinai School of Medicine | Genetically engineered swine influenza virus and uses thereof |
EP3332803A1 (en) | 2004-06-01 | 2018-06-13 | Icahn School of Medicine at Mount Sinai | Genetically engineered swine influenza virus and uses thereof |
WO2006083286A2 (en) | 2004-06-01 | 2006-08-10 | Mount Sinai School Of Medicine Of New York University | Genetically engineered swine influenza virus and uses thereof |
EP2474317A1 (en) | 2004-06-24 | 2012-07-11 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
US8486893B2 (en) | 2004-06-24 | 2013-07-16 | Biogen Idec Ma Inc. | Treatment of conditions involving demyelination |
US9068992B2 (en) | 2004-06-24 | 2015-06-30 | Biogen Ma Inc. | Screening methods for identifying Sp35 antagonists |
EP2287195A2 (en) | 2004-07-01 | 2011-02-23 | Novo Nordisk A/S | Pan-KIR2DL NK-receptor antibodies and their use in diagnostik and therapy |
WO2006003179A2 (en) | 2004-07-01 | 2006-01-12 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
EP2848942A1 (en) | 2004-07-14 | 2015-03-18 | The Regents of The University of California | Biomarkers for early detection of ovarian cancer |
EP2261672A2 (en) | 2004-07-14 | 2010-12-15 | The Regents of the University of California | Biomarkers for early detection of ovarian cancer |
EP3203241A1 (en) | 2004-07-14 | 2017-08-09 | The Regents of The University of California | Biomarkers for early detection of ovarian cancer |
EP2199801A2 (en) | 2004-07-14 | 2010-06-23 | The Regents Of The University Of California | Biomarkers for early detection of ovarian cancer |
EP2322215A2 (en) | 2004-07-16 | 2011-05-18 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody |
EP2322217A2 (en) | 2004-07-16 | 2011-05-18 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody |
EP2335727A2 (en) | 2004-07-16 | 2011-06-22 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody |
EP2204376A2 (en) | 2004-07-20 | 2010-07-07 | Sagres Discovery, Inc. | Novel therapeutic targets in cancer |
EP2329714A1 (en) | 2004-08-03 | 2011-06-08 | Biogen Idec MA Inc. | Influence of TAJ in the neuronal functions |
EP2336177A1 (en) | 2004-08-04 | 2011-06-22 | Amgen, Inc | Antibodies to DKK-1 |
EP2319925A2 (en) | 2004-08-16 | 2011-05-11 | Quark Pharmaceuticals, Inc. | Therapeutic uses of inhibitors of RTP801 |
US8840898B2 (en) | 2004-08-30 | 2014-09-23 | Biotest Ag | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
EP3805248A2 (en) | 2004-09-09 | 2021-04-14 | Genentech, Inc. | Process for concentration of antibodies and therapeutic products thereof |
EP2292636A2 (en) | 2004-09-09 | 2011-03-09 | Genentech, Inc. | Process for concentration of antibodies and therapeutic products thereof |
EP4104859A1 (en) | 2004-09-09 | 2022-12-21 | Genentech, Inc. | Process for concentration of antibodies and therapeutic products thereof |
EP4108259A1 (en) | 2004-09-09 | 2022-12-28 | Genentech, Inc. | Process for concentration of antibodies and therapeutic products thereof |
EP3073267A1 (en) | 2004-09-21 | 2016-09-28 | Medimmune, Inc. | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
US7790160B2 (en) | 2004-10-01 | 2010-09-07 | Medarex, Inc. | Method of treating CD30 positive lymphomas |
US9585374B2 (en) | 2004-10-22 | 2017-03-07 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
US11085054B2 (en) | 2004-10-22 | 2021-08-10 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
EP2527456A1 (en) | 2004-10-22 | 2012-11-28 | Revivicor Inc. | Transgenic porcines lacking endogenous immunoglobulin light chain |
EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
US7994302B2 (en) | 2004-11-17 | 2011-08-09 | Amgen Inc. | Fully human monoclonal antibodies to IL-13 |
US7585500B2 (en) | 2004-11-17 | 2009-09-08 | Amgen Inc. | Fully human monoclonal antibodies to IL-13 |
WO2006055638A2 (en) | 2004-11-17 | 2006-05-26 | Abgenix, Inc. | Fully human monoclonal antibodies to il-13 |
US9273111B2 (en) | 2004-11-29 | 2016-03-01 | Universite De Lorraine | Therapeutic TREM-1 peptides |
US10603357B2 (en) | 2004-11-29 | 2020-03-31 | Bristol-Myers Squibb Company | Therapeutic TREM-1 peptides |
WO2006056492A1 (en) | 2004-11-29 | 2006-06-01 | Bioxell Spa | Therapeutic peptides comprising sequences derived from cdr2 or cdr3 of trem-1 and uses thereof to inhibit sepsis |
EP2769990A2 (en) | 2004-12-02 | 2014-08-27 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and GLP-1 or PYY |
EP2295465A2 (en) | 2004-12-06 | 2011-03-16 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibodies to influenza M2 protein and methods of making and using same |
WO2006068975A2 (en) | 2004-12-20 | 2006-06-29 | Abgenix, Inc. | Binding proteins specific for human matriptase |
EP3699191A1 (en) | 2004-12-21 | 2020-08-26 | MedImmune Limited | Antibodies directed to angiopoietin-2 and uses thereof |
EP2284194A1 (en) | 2004-12-21 | 2011-02-16 | AstraZeneca AB | Antibodies directed to angiopoietin-2 and uses thereof |
EP3698807A1 (en) | 2005-01-21 | 2020-08-26 | Genentech, Inc. | Fixed dosing of her antibodies |
EP2361933A2 (en) | 2005-01-26 | 2011-08-31 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
US7402730B1 (en) | 2005-02-03 | 2008-07-22 | Lexicon Pharmaceuticals, Inc. | Knockout animals manifesting hyperlipidemia |
EP2520669A2 (en) | 2005-02-07 | 2012-11-07 | GeneNews Inc. | Mild osteoathritis biomarkers and uses thereof |
WO2006089133A2 (en) | 2005-02-15 | 2006-08-24 | Duke University | Anti-cd19 antibodies and uses in oncology |
EP2548575A1 (en) | 2005-02-15 | 2013-01-23 | Duke University | Anti-CD19 antibodies that mediate ADCC for use in treating autoimmune diseases |
US8207303B2 (en) | 2005-02-18 | 2012-06-26 | Medarex, Inc. | Monoclonal antibodies against CD30 lacking in fucosyl residues |
US8491898B2 (en) | 2005-02-18 | 2013-07-23 | Medarex, L.L.C. | Monoclonal antibodies against CD30 lacking in fucosyl residues |
EP2399605A1 (en) | 2005-02-23 | 2011-12-28 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
US8211430B2 (en) | 2005-03-04 | 2012-07-03 | Curedm Group Holdings, Llc | Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions |
EP2311491A1 (en) | 2005-03-08 | 2011-04-20 | Pharmacia & Upjohn Company LLC | Composition comprising an antibody against macrophage colony-stimulating factor (M-CSF) and a chelating agent |
EP2620450A2 (en) | 2005-03-08 | 2013-07-31 | Pharmacia & Upjohn Company LLC | Anti-CTLA-4 antibody compositions |
EP3300739A2 (en) | 2005-03-31 | 2018-04-04 | Agensys, Inc. | Antibodies and related molecules that bind to 161p2f10b proteins |
EP2444099A1 (en) | 2005-03-31 | 2012-04-25 | Agensys, Inc. | Antibodies and related molecules that bind to 161P2F10B proteins |
EP2083088A2 (en) | 2005-04-07 | 2009-07-29 | Novartis Vaccines and Diagnostics, Inc. | Cancer-related genes |
EP2062591A1 (en) | 2005-04-07 | 2009-05-27 | Novartis Vaccines and Diagnostics, Inc. | CACNA1E in cancer diagnosis detection and treatment |
EP3479844A1 (en) | 2005-04-15 | 2019-05-08 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
US8604174B2 (en) | 2005-04-20 | 2013-12-10 | Amgen Inc. | High affinity fully human monoclonal antibodies to interleukin-8 |
EP1874820A2 (en) * | 2005-04-20 | 2008-01-09 | Amgen Fremont Inc. | High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies |
EP1874820A4 (en) * | 2005-04-20 | 2010-09-22 | Amgen Fremont Inc | High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies |
EP2295466A2 (en) | 2005-04-25 | 2011-03-16 | Pfizer Inc. | Antibodies to myostatin |
US7807159B2 (en) | 2005-04-25 | 2010-10-05 | Amgen Fremont Inc. | Antibodies to myostatin |
EP2444420A1 (en) | 2005-04-26 | 2012-04-25 | Pfizer Inc. | P-Cadherin antibodies |
EP2444419A1 (en) | 2005-04-26 | 2012-04-25 | Pfizer Inc. | P-Cadherin antibodies |
EP2444421A1 (en) | 2005-04-26 | 2012-04-25 | Pfizer Inc. | P-Cadherin antibodies |
EP2842968A1 (en) | 2005-04-29 | 2015-03-04 | Janssen Biotech, Inc. | Anti-IL-6 antibodies, compositions, methods and uses |
EP2221316A1 (en) | 2005-05-05 | 2010-08-25 | Duke University | Anti-CD19 antibody therapy for autoimmune disease |
US8383578B2 (en) | 2005-05-25 | 2013-02-26 | Curedm Group Holdings, Llc | Peptides, derivatives and analogs thereof, and methods of using same |
US7393919B2 (en) | 2005-05-25 | 2008-07-01 | Cure Dm, Inc. | Peptides, derivatives and analogs thereof, and methods of using same |
US8829158B2 (en) | 2005-05-25 | 2014-09-09 | Curedm Group Holdings, Llc | Peptides, derivatives and analogs thereof, and methods of using same |
US7714103B2 (en) | 2005-05-25 | 2010-05-11 | Curedm, Inc. | Peptides, derivatives and analogs thereof, and methods of using same |
EP2295066A1 (en) | 2005-05-25 | 2011-03-16 | CureDM Group Holdings, LLC | Peptides, derivatives and analogs thereof, and methods of using same |
US7989415B2 (en) | 2005-05-25 | 2011-08-02 | Curedm Group Holdings, Llc | Peptides, derivatives and analogs thereof, and methods of using same |
WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
EP3501537A1 (en) | 2005-06-30 | 2019-06-26 | Janssen Biotech, Inc. | Anti-il23 antibodies, compositions, methods and uses |
EP2452694A1 (en) | 2005-06-30 | 2012-05-16 | Janssen Biotech, Inc. | Anti-IL-23 antibodies, compositions, methods and uses |
US8551476B2 (en) | 2005-07-08 | 2013-10-08 | Biogen Idec Ma Inc. | SP35 antibodies and uses thereof |
EP2478917A1 (en) | 2005-07-08 | 2012-07-25 | Biogen Idec MA Inc. | SP35 antibodies and uses thereof |
US9066984B2 (en) | 2005-07-08 | 2015-06-30 | Biogen Ma Inc. | Sp35 antibodies and uses thereof |
EP2394661A1 (en) | 2005-07-08 | 2011-12-14 | Biogen Idec MA Inc. | Sp35 antibodies and uses thereof |
EP2238986A2 (en) | 2005-07-08 | 2010-10-13 | Biogen Idec MA Inc. | Sp35 antibodies and uses thereof |
EP2388276A2 (en) | 2005-07-18 | 2011-11-23 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
EP2397497A2 (en) | 2005-07-18 | 2011-12-21 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
EP2388277A2 (en) | 2005-07-18 | 2011-11-23 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
US7868140B2 (en) | 2005-07-18 | 2011-01-11 | Amgen Inc. | Human anti-B7RP1 neutralizing antibodies |
US10072090B2 (en) | 2005-07-18 | 2018-09-11 | Amgen Inc. | Human anti-B7RP1 neutralizing antibodies |
US8981071B2 (en) | 2005-07-18 | 2015-03-17 | Amgen, Inc. | Human anti-B7RP1 neutralizing antibodies |
US9266945B2 (en) | 2005-07-18 | 2016-02-23 | Amgen Inc. | Human anti-B7RP1 neutralizing antibodies |
EP2397498A2 (en) | 2005-07-18 | 2011-12-21 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
EP2397496A2 (en) | 2005-07-18 | 2011-12-21 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
EP2397499A2 (en) | 2005-07-18 | 2011-12-21 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
US8652469B2 (en) | 2005-07-28 | 2014-02-18 | Novartis Ag | M-CSF-specific monoclonal antibody and uses thereof |
EP2573114A1 (en) | 2005-08-10 | 2013-03-27 | MacroGenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
EP2520588A1 (en) | 2005-08-19 | 2012-11-07 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500356A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2495257A2 (en) | 2005-08-19 | 2012-09-05 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500358A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
WO2007024715A2 (en) | 2005-08-19 | 2007-03-01 | Abbott Laboratories | Dual variable domain immunoglobin and uses thereof |
EP2500353A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500354A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500352A1 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500355A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500357A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2500359A2 (en) | 2005-08-19 | 2012-09-19 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
EP2960253A1 (en) | 2005-09-07 | 2015-12-30 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
EP3381945A1 (en) | 2005-09-07 | 2018-10-03 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
EP2447283A2 (en) | 2005-09-07 | 2012-05-02 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1) |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
US8906864B2 (en) | 2005-09-30 | 2014-12-09 | AbbVie Deutschland GmbH & Co. KG | Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use |
EP2319941A2 (en) | 2005-10-21 | 2011-05-11 | GeneNews Inc. | Method and apparatus for correlating levels of biomarker products with disease |
EP2500030A2 (en) | 2005-11-04 | 2012-09-19 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
EP2510934A1 (en) | 2005-11-04 | 2012-10-17 | Biogen Idec MA Inc. | Methods for promoting neurite outgrowth and survival of dopaminergic neurons |
EP2998318A1 (en) | 2005-11-04 | 2016-03-23 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
EP3299027A1 (en) | 2005-11-04 | 2018-03-28 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
WO2007056352A2 (en) | 2005-11-07 | 2007-05-18 | The Scripps Research Institute | Compositions and methods for controlling tissue factor signaling specificity |
WO2007059082A1 (en) | 2005-11-10 | 2007-05-24 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen |
EP2548583A2 (en) | 2005-11-10 | 2013-01-23 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen |
US8007995B2 (en) | 2005-11-10 | 2011-08-30 | Bristol-Myers Squibb Company | Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers |
EP2366715A2 (en) | 2005-11-14 | 2011-09-21 | Amgen Inc. | Rankl Antibody-PTH/PTHRP Chimeric Molecules |
EP2816060A1 (en) | 2005-11-14 | 2014-12-24 | Amgen Inc. | Rankl antibody-PTH/PTHRP chimeric molecules |
EP3345927A1 (en) | 2005-11-25 | 2018-07-11 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
EP4219557A1 (en) | 2005-11-25 | 2023-08-02 | Kyowa Kirin Co., Ltd. | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
EP3098238A1 (en) | 2005-11-25 | 2016-11-30 | Kyowa Hakko Kirin Co., Ltd. | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
EP2567973A2 (en) | 2005-11-28 | 2013-03-13 | Zymogenetics, Inc. | IL-21 antagonists |
EP2805971A1 (en) | 2005-11-28 | 2014-11-26 | ZymoGenetics, Inc. | IL-21 antagonists |
US10323084B2 (en) | 2005-11-30 | 2019-06-18 | Abbvie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
EP2289909A1 (en) | 2005-11-30 | 2011-03-02 | Abbott Laboratories | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
US10538581B2 (en) | 2005-11-30 | 2020-01-21 | Abbvie Inc. | Anti-Aβ globulomer 4D10 antibodies |
US10208109B2 (en) | 2005-11-30 | 2019-02-19 | Abbvie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
EP2623516A2 (en) | 2005-12-02 | 2013-08-07 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R |
EP3006466A2 (en) | 2005-12-02 | 2016-04-13 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
EP2543384A2 (en) | 2005-12-02 | 2013-01-09 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
EP2251034A1 (en) | 2005-12-02 | 2010-11-17 | Mount Sinai School of Medicine of New York University | Chimeric Newcastle Disease viruses presenting non-native surface proteins and uses thereof |
EP2529747A2 (en) | 2005-12-02 | 2012-12-05 | Mount Sinai School of Medicine | Chimeric Newcastle Disease viruses presenting non-native surface proteins and uses thereof |
US9062111B2 (en) | 2005-12-07 | 2015-06-23 | Medarex, L.L.C. | CTLA-4 antibody dosage escalation regimens |
EP2404616A2 (en) | 2005-12-13 | 2012-01-11 | AstraZeneca AB | Binding proteins specific for insulin-like growth factors and uses thereof |
EP3309170A1 (en) | 2005-12-15 | 2018-04-18 | Genentech, Inc. | Polyubiquitin antibodies |
EP2518083A2 (en) | 2005-12-15 | 2012-10-31 | Medimmune Limited | Combination of angiopoietin-2 antagonist and of VEGF-A, KDR and/or FLTL antagonist for treating cancer |
EP2325208A1 (en) | 2005-12-15 | 2011-05-25 | Genentech, Inc. | Polyubiquitin antibodies |
WO2007068895A1 (en) | 2005-12-15 | 2007-06-21 | Astrazeneca Ab | Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer |
US8771695B2 (en) | 2005-12-30 | 2014-07-08 | U3 Pharma Gmbh | Antibodies directed to HER-3 and uses thereof |
EP2993187A2 (en) | 2005-12-30 | 2016-03-09 | U3 Pharma GmbH | Antibodies directed to her-3 and uses thereof |
EP3196213A2 (en) | 2005-12-30 | 2017-07-26 | Daiichi Sankyo Europe GmbH | Antibodies directed to her-3 and uses thereof |
WO2007077028A2 (en) | 2005-12-30 | 2007-07-12 | U3 Pharma Ag | Antibodies directed to her-3 and uses thereof |
US7705130B2 (en) | 2005-12-30 | 2010-04-27 | U3 Pharma Gmbh | Antibodies directed to HER-3 and uses thereof |
EP3950715A1 (en) | 2005-12-30 | 2022-02-09 | Amgen Inc. | Antibodies directed to her-3 and uses thereof |
US9988462B2 (en) | 2005-12-30 | 2018-06-05 | Daiichi Sankyo Europe Gmbh | Material and methods for treating or preventing HER-3 associated diseases |
EP2594585A1 (en) | 2006-01-10 | 2013-05-22 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using IL-31 antagonists |
EP2749571A2 (en) | 2006-01-10 | 2014-07-02 | ZymoGenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using IL-31RA and OSMRb antagonists |
EP2463305A1 (en) | 2006-01-12 | 2012-06-13 | Alexion Pharmaceuticals, Inc. | Antibodies to OX-2/CD200 and uses thereof |
EP2402443A2 (en) | 2006-01-20 | 2012-01-04 | Quark Pharmaceuticals, Inc. | Therapeutic uses of inhibitors of rtp801 |
EP2526968A2 (en) | 2006-01-27 | 2012-11-28 | Biogen Idec MA Inc. | Nogo receptor antagonists |
EP2311477A1 (en) | 2006-03-20 | 2011-04-20 | Japan Science and Technology Agency | Use of ip3 receptor-binding protein for controlling phosphatidylinositol metabolism |
US8278421B2 (en) | 2006-03-20 | 2012-10-02 | Xoma Techolology Ltd. | Human antibodies specific for gastrin materials and methods |
EP2311478A1 (en) | 2006-03-20 | 2011-04-20 | Japan Science and Technology Agency | Use of ip3 receptor-binding protein for controlling intracellular pH |
US7910798B2 (en) | 2006-03-31 | 2011-03-22 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
US8232449B2 (en) | 2006-03-31 | 2012-07-31 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
US9220244B2 (en) | 2006-03-31 | 2015-12-29 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
EP2614839A2 (en) | 2006-04-05 | 2013-07-17 | Genentech, Inc. | Method for using BOC/CDO to modulate hedgehog signaling |
US8071323B2 (en) | 2006-04-07 | 2011-12-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human monoclonal antibodies that bind human insulin like growth factors and their use |
EP2357202A1 (en) | 2006-04-10 | 2011-08-17 | AstraZeneca AB | Targeted binding agents directed to Upar and uses thereof |
EP2407483A1 (en) | 2006-04-13 | 2012-01-18 | Novartis Vaccines and Diagnostics, Inc. | Methods of treating, diagnosing or detecting cancers |
EP2446904A2 (en) | 2006-05-30 | 2012-05-02 | Genentech, Inc. | Anti-CD22 antibodies, their immunoconjugates and uses thereof |
EP2447282A2 (en) | 2006-05-30 | 2012-05-02 | Genentech, Inc. | Anti-CD22 Antibodies, their Immunoconjugates and uses thereof |
EP2380908A1 (en) | 2006-06-02 | 2011-10-26 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (hgf) binding proteins |
EP2361934A2 (en) | 2006-06-02 | 2011-08-31 | Aveo Pharmaceuticals, Inc. | Hepatocyte growth factor (HGF) binding proteins |
US7803377B2 (en) | 2006-06-06 | 2010-09-28 | Genentech, Inc. | Anti-DLL4 antibodies and methods using same |
EP2815764A1 (en) | 2006-06-14 | 2014-12-24 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity |
WO2007147090A2 (en) | 2006-06-14 | 2007-12-21 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity |
EP2505209A1 (en) | 2006-06-26 | 2012-10-03 | MacroGenics, Inc. | Fcgamma-RIIB-specific antibodies and methods of the use thereof |
EP2193801A2 (en) | 2006-06-28 | 2010-06-09 | Yeda Research And Development Co. Ltd. | Caspase-8 and inflammation, infection and wound healing |
EP2671946A1 (en) | 2006-06-30 | 2013-12-11 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
WO2008105797A2 (en) | 2006-06-30 | 2008-09-04 | Bristol-Myers Squibb Company | Polynucleotides encoding novel pcsk9 variants |
EP2639301A2 (en) | 2006-06-30 | 2013-09-18 | Bristol-Myers Squibb Company | Polynucleotides encoding novel PCSK9 variants |
WO2008003319A1 (en) | 2006-07-04 | 2008-01-10 | Genmab A/S | Cd20 binding molecules for the treatment of copd |
EP2479284A2 (en) | 2006-07-13 | 2012-07-25 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
EP2447275A1 (en) | 2006-07-13 | 2012-05-02 | University of Iowa Research Foundation | Methods and reagents for treatment of age-related macular degeneration |
US8460667B2 (en) | 2006-07-18 | 2013-06-11 | Sanofi | EPHA2 receptor antagonist antibodies |
USRE47123E1 (en) | 2006-07-18 | 2018-11-13 | Sanofi | EPHA2 receptor antagonist antibodies |
EP2420513A1 (en) | 2006-08-03 | 2012-02-22 | MedImmune Limited | Targeted binding agents directed to PDGFR-alpha and uses thereof |
US8894998B2 (en) | 2006-08-03 | 2014-11-25 | Medimmune Limited | Antibodies directed to αVβ6 and uses thereof |
EP2420514A1 (en) | 2006-08-03 | 2012-02-22 | MedImmune Limited | Targeted binding agents directed to PDGFR-alpha and uses thereof |
US8398975B2 (en) | 2006-08-03 | 2013-03-19 | Medimmune Limited | Antibodies directed to αVβ6 and uses thereof |
US9006398B2 (en) | 2006-08-04 | 2015-04-14 | Novartis Ag | EPHB3-specific antibody and uses thereof |
EP2511301A2 (en) | 2006-08-04 | 2012-10-17 | Medimmune Limited | Human antibodies to ERBB2 |
EP3018144A1 (en) | 2006-08-18 | 2016-05-11 | XOMA Technology Ltd. | Prlr-specific antibody and uses thereof |
EP3415532A1 (en) | 2006-08-18 | 2018-12-19 | XOMA Technology Ltd. | Prlr-specific antibody and uses thereof |
US9005614B2 (en) | 2006-08-18 | 2015-04-14 | Novartis Ag | PRLR-specific antibody and uses thereof |
EP2423231A2 (en) | 2006-08-18 | 2012-02-29 | Novartis AG | PRLR-specific antibody and uses thereof |
US8337852B2 (en) | 2006-08-22 | 2012-12-25 | G2 Inflammation Pty Ltd | Anti-C5aR antibodies with improved properties |
EP2484696A1 (en) | 2006-08-28 | 2012-08-08 | Kyowa Hakko Kirin Co., Ltd. | Antagonistic human light-specific human monoclonal antibodies |
EP2292663A2 (en) | 2006-08-28 | 2011-03-09 | Kyowa Hakko Kirin Co., Ltd. | Antagonistic human light-specific human monoclonal antibodies |
US10118970B2 (en) | 2006-08-30 | 2018-11-06 | Genentech, Inc. | Multispecific antibodies |
US11008401B2 (en) | 2006-08-30 | 2021-05-18 | Genentech, Inc. | Multispecific antibodies |
EP2471816A1 (en) | 2006-08-30 | 2012-07-04 | Genentech, Inc. | Multispecific antibodies |
US11851501B2 (en) | 2006-08-30 | 2023-12-26 | Genentech, Inc. | Multispecific antibodies |
US11230697B2 (en) | 2006-09-01 | 2022-01-25 | Therapeutic Human Polyclonals Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
EP3524685A1 (en) | 2006-09-08 | 2019-08-14 | AbbVie Bahamas Ltd. | Interleukin -13 binding proteins |
EP3910065A1 (en) | 2006-09-08 | 2021-11-17 | AbbVie Bahamas Ltd. | Interleukin -13 binding proteins |
US10086076B2 (en) | 2006-09-08 | 2018-10-02 | Abbvie Inc. | Interleukin-13 binding proteins |
EP3339445A1 (en) | 2006-09-08 | 2018-06-27 | AbbVie Bahamas Ltd. | Interleukin -13 binding proteins |
US11344621B2 (en) | 2006-09-08 | 2022-05-31 | Abbvie, Inc. | Interleukin-13 binding proteins |
EP2845912A1 (en) | 2006-09-12 | 2015-03-11 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of lung cancer using KIT gene as genetic marker |
EP2386655A2 (en) | 2006-09-12 | 2011-11-16 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of lung cancer using KIT or KDG gene as genetic marker |
EP2862579A1 (en) | 2006-10-04 | 2015-04-22 | Dana-Farber Cancer Institute, Inc. | Tumor immunity |
EP2407548A1 (en) | 2006-10-16 | 2012-01-18 | MedImmune, LLC | Molecules with reduced half-lives, compositions and uses thereof |
EP3909980A1 (en) | 2006-10-19 | 2021-11-17 | Sanofi | Novel anti-cd38 antibodies for the treatment of cancer |
EP3498735A1 (en) | 2006-10-19 | 2019-06-19 | Sanofi | Novel anti-cd38 antibodies for the treatment of leukemia |
US8383106B2 (en) | 2006-10-24 | 2013-02-26 | Emergent Product Development Seattle, Llc | Materials and methods for improved immunoglycoproteins |
US7846434B2 (en) | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
EP2845866A1 (en) | 2006-10-27 | 2015-03-11 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
US8785400B2 (en) | 2006-11-22 | 2014-07-22 | Curedm Group Holdings, Llc | Methods and compositions relating to islet cell neogenesis |
EP2431053A1 (en) | 2006-11-27 | 2012-03-21 | Patrys Limited | Novel glycosylated peptide target in neoplastic cells |
US9951125B2 (en) | 2006-11-30 | 2018-04-24 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
EP2687232A1 (en) | 2006-12-06 | 2014-01-22 | MedImmune, LLC | Methods of treating systemic lupus erythematosus |
EP2494988A1 (en) | 2006-12-07 | 2012-09-05 | Novartis AG | Antagonist antibodies against EPHB3 |
WO2008073300A2 (en) | 2006-12-08 | 2008-06-19 | Lexicon Pharmaceuticals, Inc. | Monoclonal antibodies against angptl3 |
EP2610267A1 (en) | 2006-12-18 | 2013-07-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
EP3124045A2 (en) | 2006-12-20 | 2017-02-01 | Xoma (Us) Llc | Treatment of il-1 beta related diseases |
EP2436696A1 (en) | 2007-01-05 | 2012-04-04 | University of Zurich | Method of providing disease-specific binding molecules and targets |
WO2008081008A1 (en) | 2007-01-05 | 2008-07-10 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
EP2426143A2 (en) | 2007-01-05 | 2012-03-07 | University of Zurich | Method of providing disease-specific binding molecules and targets |
EP3239174A1 (en) | 2007-01-05 | 2017-11-01 | University of Zurich | Anti-beta-amyloid antibody and uses thereof |
EP3239175A1 (en) | 2007-01-05 | 2017-11-01 | University of Zurich | Method of providing disease-specific binding molecules and targets |
US8609407B2 (en) | 2007-01-09 | 2013-12-17 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
EP2740744A2 (en) | 2007-01-09 | 2014-06-11 | Biogen Idec MA Inc. | SP35 antibodies and uses thereof |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
US9051368B2 (en) | 2007-01-16 | 2015-06-09 | Abbvie, Inc. | Methods for treating psoriasis by administering an antibody which binds an epitope of the p40 subunit of IL-12 and/or IL-23 |
EP2468776A2 (en) | 2007-02-09 | 2012-06-27 | Genentech, Inc. | Anti-Robo4 antibodies and uses therefor |
US8114606B2 (en) | 2007-02-16 | 2012-02-14 | The Board Of Trustees Of Southern Illinois University | ARL-1 specific antibodies |
US8685666B2 (en) | 2007-02-16 | 2014-04-01 | The Board Of Trustees Of Southern Illinois University | ARL-1 specific antibodies and uses thereof |
EP2436781A1 (en) | 2007-02-22 | 2012-04-04 | Genentech, Inc. | Methods for detecting inflammatory bowel disease |
US7981418B2 (en) | 2007-03-02 | 2011-07-19 | Genentech, Inc. | Predicting response to a HER inhibitor |
EP2899541A1 (en) | 2007-03-02 | 2015-07-29 | Genentech, Inc. | Predicting response to a HER dimerisation inhbitor based on low HER3 expression |
EP2465950A2 (en) | 2007-03-13 | 2012-06-20 | Amgen Inc. | K-RAS mutations and anti-EGFR antibody therapy |
EP2412828A1 (en) | 2007-03-13 | 2012-02-01 | Amgen Inc. | K-ras and B-raf mutations and anti-EGFr antibody therapy |
WO2008112269A2 (en) | 2007-03-13 | 2008-09-18 | Amgen Inc. | K-ras mutations and anti-egfr antibody therapy |
EP2474556A2 (en) | 2007-03-14 | 2012-07-11 | Novartis AG | APCDD1 inhibitors for treating, diagnosing or detecting cancer |
EP3524626A1 (en) | 2007-03-22 | 2019-08-14 | Biogen MA Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
US10317393B2 (en) | 2007-03-23 | 2019-06-11 | Academia Sinica | Alkynyl sugar analogs for labeling and visualization of glycoconjugates in cells |
US9816981B2 (en) | 2007-03-23 | 2017-11-14 | Academia Sinica | Alkynyl sugar analogs for labeling and visualization of glycoconjugates in cells |
WO2008118324A2 (en) | 2007-03-26 | 2008-10-02 | Macrogenics, Inc. | Composition and method of treating cancer with an anti-uroplakin ib antibody |
EP2703007A1 (en) | 2007-03-30 | 2014-03-05 | MedImmune, LLC | Antibodies with decreased deamidation profiles |
US7867494B2 (en) | 2007-04-02 | 2011-01-11 | Amgen Fremont Inc. | Anti-IgE antibodies |
EP3072525A1 (en) | 2007-05-14 | 2016-09-28 | MedImmune, LLC | Methods of reducing basophil levels |
EP2612924A2 (en) | 2007-05-21 | 2013-07-10 | Genentech, Inc. | Methods and compositions for indentifying and treating lupus |
EP3318643A2 (en) | 2007-05-21 | 2018-05-09 | Genentech, Inc. | Methods and compositions for identifying and treating lupus |
US9388233B2 (en) | 2007-06-01 | 2016-07-12 | Roland Buelow | Rat having a disrupted immunoglobulin gene |
US8703485B2 (en) * | 2007-06-01 | 2014-04-22 | Omt, Inc. | Germ cells having inactivated endogenous immunoglobulin genes, and transgenic animals derived therefrom |
US8907157B2 (en) | 2007-06-01 | 2014-12-09 | Omt, Inc. | Methods for producing transgenic rodents having recombinant immunoglobulin loci |
US10072069B2 (en) | 2007-06-01 | 2018-09-11 | Open Monoclonal Technology, Inc. | Humanized monoclonal antibodies from a transgenic rat |
US20100212035A1 (en) * | 2007-06-01 | 2010-08-19 | Omt, Inc. | Compositions and Methods for Producing Transgenic Mammals Having Recombinant Immunoglobulin Loci |
EP2592156A2 (en) | 2007-06-08 | 2013-05-15 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
EP3424951A1 (en) | 2007-06-21 | 2019-01-09 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
WO2008157379A2 (en) | 2007-06-21 | 2008-12-24 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
WO2009005726A1 (en) | 2007-06-29 | 2009-01-08 | Amgen Inc. | Antigen binding proteins that bind par-2 |
EP2562186A1 (en) | 2007-06-29 | 2013-02-27 | Amgen Inc. | Antigen binding proteins that bind PAR-2 |
EP4245766A2 (en) | 2007-07-09 | 2023-09-20 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
EP4335863A2 (en) | 2007-07-09 | 2024-03-13 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
EP3597659A1 (en) | 2007-07-09 | 2020-01-22 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
EP2586788A1 (en) | 2007-07-09 | 2013-05-01 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
EP3327026A1 (en) | 2007-07-09 | 2018-05-30 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
EP4219522A2 (en) | 2007-07-09 | 2023-08-02 | Genentech, Inc. | Prevention of disulfide bond reduction during recombinant production of polypeptides |
WO2009054873A2 (en) | 2007-08-02 | 2009-04-30 | Novimmune S.A. | Anti-rantes antibodies and methods of use thereof |
EP2592093A1 (en) | 2007-08-21 | 2013-05-15 | Amgen, Inc | Human c-fms antigen binding proteins |
EP2589610A1 (en) | 2007-08-21 | 2013-05-08 | Amgen, Inc | Human c-fms antigen binding proteins |
EP3330292A1 (en) | 2007-08-21 | 2018-06-06 | Amgen, Inc | Human c-fms antigen binding proteins |
US8168762B2 (en) | 2007-08-23 | 2012-05-01 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
US9045547B2 (en) | 2007-08-23 | 2015-06-02 | Amgen Inc. | Methods of using antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
US9920134B2 (en) | 2007-08-23 | 2018-03-20 | Amgen Inc. | Monoclonal antibodies to proprotein convertase subtilisin kexin type 9 (PCSK9) |
US8030457B2 (en) | 2007-08-23 | 2011-10-04 | Amgen, Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
US9056915B2 (en) | 2007-08-23 | 2015-06-16 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
DE202008018562U1 (en) | 2007-08-23 | 2015-11-02 | Amgen Inc. | Antigen-binding Proteins Against Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) |
EP3666797A1 (en) | 2007-08-23 | 2020-06-17 | Amgen, Inc | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) |
US9493576B2 (en) | 2007-08-23 | 2016-11-15 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
EP4248976A2 (en) | 2007-08-23 | 2023-09-27 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) |
US8647622B2 (en) | 2007-08-29 | 2014-02-11 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their use |
US9175087B2 (en) | 2007-08-29 | 2015-11-03 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their use |
US9228019B2 (en) | 2007-08-29 | 2016-01-05 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their use |
US9815902B2 (en) | 2007-08-29 | 2017-11-14 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their uses |
US9243067B2 (en) | 2007-08-29 | 2016-01-26 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their use |
US8980262B2 (en) | 2007-08-29 | 2015-03-17 | Sanofi | Humanized anti-CXCR5 antibodies, derivatives thereof and their use |
US8816047B2 (en) | 2007-08-30 | 2014-08-26 | Cure DM Group Holdings, LLC | Compositions and methods of using proislet peptides and analogs thereof |
WO2009033121A2 (en) | 2007-09-06 | 2009-03-12 | University Of Washington | Molecules and methods for treatment and detection of diabetes |
EP2236519A1 (en) | 2007-09-18 | 2010-10-06 | Amgen, Inc | Human GM-CSF antigen binding proteins |
EP2497783A2 (en) | 2007-09-26 | 2012-09-12 | U3 Pharma GmbH | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
WO2009040134A1 (en) | 2007-09-26 | 2009-04-02 | U3 Pharma Gmbh | Heparin-binding epidermal growth factor-like growth factor antigen binding proteins |
US9320797B2 (en) | 2007-09-27 | 2016-04-26 | Amgen Inc. | Pharmaceutical formulations |
US10653781B2 (en) | 2007-09-27 | 2020-05-19 | Amgen Inc. | Pharmaceutical formulations |
EP2573119A1 (en) | 2007-10-15 | 2013-03-27 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2573117A1 (en) | 2007-10-15 | 2013-03-27 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2574626A1 (en) | 2007-10-15 | 2013-04-03 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2574629A1 (en) | 2007-10-15 | 2013-04-03 | Sanofi | Antibodies that bind il-4 and/or il-13 and their uses |
EP3686220A1 (en) | 2007-10-15 | 2020-07-29 | Sanofi | Antibodies that bind il-4 and/or il-13 and their uses |
EP2574630A1 (en) | 2007-10-15 | 2013-04-03 | Sanofi | Antibodies that bind il-4 and/or il-13 and their uses |
EP2573115A1 (en) | 2007-10-15 | 2013-03-27 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2573118A1 (en) | 2007-10-15 | 2013-03-27 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
US9732162B2 (en) | 2007-10-15 | 2017-08-15 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2573116A1 (en) | 2007-10-15 | 2013-03-27 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
US11453727B2 (en) | 2007-10-15 | 2022-09-27 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
US10759871B2 (en) | 2007-10-15 | 2020-09-01 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
US8388965B2 (en) | 2007-10-15 | 2013-03-05 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
US9738728B2 (en) | 2007-10-15 | 2017-08-22 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2573121A1 (en) | 2007-10-15 | 2013-03-27 | Sanofi | Antibodies that bind il-4 and/or il-13 and their uses |
WO2009061818A1 (en) | 2007-11-05 | 2009-05-14 | Medimmune, Llc | Methods of treating scleroderma |
US9068230B2 (en) | 2007-11-07 | 2015-06-30 | Genentech, Inc. | Methods and compositions for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
EP3360567A1 (en) | 2007-11-07 | 2018-08-15 | Genentech, Inc. | Amp for use in treating microbial disorders |
EP2918605A1 (en) | 2007-11-12 | 2015-09-16 | U3 Pharma GmbH | Axl antibodies |
EP3381445A2 (en) | 2007-11-15 | 2018-10-03 | Amgen Inc. | Aqueous formulation of antibody stablised by antioxidants for parenteral administration |
WO2009064944A2 (en) | 2007-11-16 | 2009-05-22 | Nuvelo, Inc. | Antibodies to lrp6 |
EP3211011A1 (en) | 2007-11-16 | 2017-08-30 | Nuvelo, Inc. | Antibodies to lrp6 |
US9308257B2 (en) | 2007-11-28 | 2016-04-12 | Medimmune, Llc | Protein formulation |
EP2851372A1 (en) | 2007-11-30 | 2015-03-25 | Genentech, Inc. | Anti-VEGF antibodies |
EP3173425A1 (en) | 2007-11-30 | 2017-05-31 | Genentech, Inc. | Anti-vegf antibodies |
WO2009086003A1 (en) | 2007-12-20 | 2009-07-09 | Xoma Technology Ltd. | Methods for the treatment of gout |
EP2851373A1 (en) | 2007-12-20 | 2015-03-25 | Xoma (Us) Llc | Methods for the treatment of gout |
WO2009085200A2 (en) | 2007-12-21 | 2009-07-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
EP2261254A2 (en) | 2007-12-21 | 2010-12-15 | Amgen, Inc | Anti-amyloid antibodies and uses thereof |
US9011864B2 (en) | 2007-12-26 | 2015-04-21 | Biotest Ag | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
EP2801584A1 (en) | 2007-12-26 | 2014-11-12 | Biotest AG | Agents targeting CD138 and uses thereof |
WO2009092011A1 (en) | 2008-01-18 | 2009-07-23 | Medimmune, Llc | Cysteine engineered antibodies for site-specific conjugation |
US9175078B2 (en) | 2008-01-25 | 2015-11-03 | Amgen Inc. | Ferroportin antibodies and methods of use |
WO2009094551A1 (en) | 2008-01-25 | 2009-07-30 | Amgen Inc. | Ferroportin antibodies and methods of use |
EP2574628A1 (en) | 2008-01-25 | 2013-04-03 | Amgen Inc. | Ferroportin antibodies and methods of use |
EP2803675A2 (en) | 2008-01-25 | 2014-11-19 | Amgen, Inc | Ferroportin antibodies and methods of use |
US9688759B2 (en) | 2008-01-25 | 2017-06-27 | Amgen, Inc. | Ferroportin antibodies and methods of use |
WO2009100309A2 (en) | 2008-02-08 | 2009-08-13 | Medimmune, Llc | Anti-ifnar1 antibodies with reduced fc ligand affinity |
WO2009098700A1 (en) | 2008-02-10 | 2009-08-13 | Yeda Research And Development Co. Ltd | Siva 3, its preparation and use |
US8808701B2 (en) | 2008-02-20 | 2014-08-19 | G2 Inflammation Pty Ltd | Methods of inhibiting the interaction of C5aR with C5a with anti-C5aR antibodies |
US8361468B2 (en) | 2008-02-20 | 2013-01-29 | G2 Inflammation Pty Ltd | Humanized anti-C5aR antibodies |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
US9605069B2 (en) | 2008-02-29 | 2017-03-28 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM a protein and uses thereof |
EP3309173A1 (en) | 2008-02-29 | 2018-04-18 | AbbVie Deutschland GmbH & Co KG | Monoclonal antibodies against the rgm a protein and uses thereof |
EP2098537A2 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Identification of antigen- or ligand-specific binding proteins |
EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
US8716194B2 (en) | 2008-03-05 | 2014-05-06 | 4-Antibody Ag | Identification of antigen or ligand-specific binding proteins |
US8748353B2 (en) | 2008-03-05 | 2014-06-10 | 4-Antibody Ag | Identification of antigen or ligand-specific binding proteins |
US9593327B2 (en) | 2008-03-05 | 2017-03-14 | Agenus Inc. | Identification of antigen or ligand-specific binding proteins |
US10502745B2 (en) | 2008-03-05 | 2019-12-10 | Agenus Inc. | Identification of antigen- or ligand-specific binding proteins |
US8945545B2 (en) | 2008-03-18 | 2015-02-03 | Abbvie Inc. | Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23 |
WO2009118300A1 (en) | 2008-03-25 | 2009-10-01 | Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by down-regulating frizzled-4 and/or frizzled-1 |
EP2631302A2 (en) | 2008-03-31 | 2013-08-28 | Genentech, Inc. | Compositions and methods for treating and diagnosing asthma |
WO2009131203A1 (en) | 2008-04-25 | 2009-10-29 | 東レ株式会社 | Nucleic acid containing chimeric gene derived from hepatitis type-c virus |
US9029508B2 (en) | 2008-04-29 | 2015-05-12 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
EP2899209A1 (en) | 2008-04-29 | 2015-07-29 | Abbvie Inc. | Dual Variable Domain Immunoglobulins and uses thereof |
WO2009139822A1 (en) | 2008-05-01 | 2009-11-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
EP2816059A1 (en) | 2008-05-01 | 2014-12-24 | Amgen, Inc | Anti-hepcidin antibodies and methods of use |
EP2620448A1 (en) | 2008-05-01 | 2013-07-31 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
US11319526B2 (en) | 2008-05-02 | 2022-05-03 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
EP2500361A1 (en) | 2008-05-09 | 2012-09-19 | Abbott GmbH & Co. KG | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
US8323651B2 (en) | 2008-05-09 | 2012-12-04 | Abbott Laboratories | Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof |
EP2116556A1 (en) | 2008-05-09 | 2009-11-11 | Abbott GmbH & Co. KG | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
US9394363B2 (en) | 2008-05-09 | 2016-07-19 | AbbVie Deutschland GmbH & Co. KG | Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof |
EP3059248A1 (en) | 2008-05-09 | 2016-08-24 | Abbvie Deutschland GmbH & Co. KG | Antibodies to receptor of advanced glycation end products (rage) and uses thereof |
EP2599793A1 (en) | 2008-05-29 | 2013-06-05 | Nuclea Biotechnologies, Inc. | Anti-phospho-akt antibodies |
US9109026B2 (en) | 2008-06-03 | 2015-08-18 | Abbvie, Inc. | Dual variable domain immunoglobulins and uses thereof |
US9035027B2 (en) | 2008-06-03 | 2015-05-19 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2009149185A2 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
EP3002299A1 (en) | 2008-06-03 | 2016-04-06 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2010004438A2 (en) | 2008-06-16 | 2010-01-14 | Patrys Limited | Lm-antibodies, functional fragments, lm-1 target antigen, and methods for making and using same |
US9951124B2 (en) | 2008-06-27 | 2018-04-24 | Merus N.V. | Antibody producing non-human mammals |
US11559049B2 (en) | 2008-06-27 | 2023-01-24 | Merus N.V. | Antibody producing non-human animals |
US9944695B2 (en) | 2008-06-27 | 2018-04-17 | Merus N.V. | Antibody producing non-human mammals |
US10966411B2 (en) | 2008-06-27 | 2021-04-06 | Merus N.V. | Antibody producing non-human mammals |
US11925174B2 (en) | 2008-06-27 | 2024-03-12 | Merus N.V. | Antibody producing non-human animals |
US11785924B2 (en) | 2008-06-27 | 2023-10-17 | Merus N.V. | Antibody producing non-human animals |
US9765133B2 (en) | 2008-06-27 | 2017-09-19 | Merus N.V. | Antibody producing non-human mammals |
EP2671891A2 (en) | 2008-06-27 | 2013-12-11 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
EP2810654A1 (en) | 2008-07-08 | 2014-12-10 | AbbVie Inc. | Prostaglandin E2 binding proteins and uses thereof |
US8822645B2 (en) | 2008-07-08 | 2014-09-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
US8058406B2 (en) | 2008-07-09 | 2011-11-15 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
EP2982695A1 (en) | 2008-07-09 | 2016-02-10 | Biogen MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
US9745375B2 (en) | 2008-07-09 | 2017-08-29 | Biogen Ma Inc. | Compositions comprising antibodies to LINGO or fragments thereof |
US8425910B2 (en) | 2008-07-09 | 2013-04-23 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
US10274488B2 (en) | 2008-07-15 | 2019-04-30 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
KR20160116056A (en) | 2008-08-14 | 2016-10-06 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | Anti-il-12/il-23 antibodies |
US8710191B2 (en) | 2008-08-18 | 2014-04-29 | Pfizer Inc. | Antibodies to CCR2 |
US9238691B2 (en) | 2008-08-18 | 2016-01-19 | Pfizer Inc. | Nucleic acids encoding antibodies to CCR2 |
US8193321B2 (en) | 2008-09-03 | 2012-06-05 | Genentech, Inc. | Multispecific antibodies |
US9017686B2 (en) | 2008-09-03 | 2015-04-28 | Genentech, Inc. | Multispecific antibodies |
US9522960B2 (en) | 2008-09-03 | 2016-12-20 | Genentech, Inc. | Multispecific antibodies |
WO2010027364A1 (en) | 2008-09-07 | 2010-03-11 | Glyconex Inc. | Anti-extended type i glycosphingolipid antibody, derivatives thereof and use |
EP2927244A1 (en) | 2008-09-19 | 2015-10-07 | MedImmune, LLC | Antibodies directed to DLL4 and uses thereof |
US10575504B2 (en) | 2008-09-30 | 2020-03-03 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US10555506B2 (en) | 2008-09-30 | 2020-02-11 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US10492476B2 (en) | 2008-09-30 | 2019-12-03 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US10561123B2 (en) | 2008-09-30 | 2020-02-18 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US9346873B2 (en) | 2008-09-30 | 2016-05-24 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US10638736B2 (en) | 2008-09-30 | 2020-05-05 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
EP3524620A1 (en) | 2008-10-14 | 2019-08-14 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
EP3351628A1 (en) | 2008-10-24 | 2018-07-25 | The Government of The United States of America as represented by The Secretary, Department of Health and Human Services | Human ebola virus species and compositions and methods thereof |
WO2010048615A2 (en) | 2008-10-24 | 2010-04-29 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services, Center For Disease Control And Prevention | Human ebola virus species and compositions and methods thereof |
US10149461B2 (en) | 2008-10-27 | 2018-12-11 | Revivicor, Inc. | Immunocompromised ungulates |
WO2010052288A1 (en) | 2008-11-07 | 2010-05-14 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Teneurin and cancer |
EP3974448A1 (en) | 2008-11-10 | 2022-03-30 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complementassociated disorders |
EP2894166A1 (en) | 2008-11-10 | 2015-07-15 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
EP2894165A1 (en) | 2008-11-10 | 2015-07-15 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
EP3121197A1 (en) | 2008-11-10 | 2017-01-25 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
WO2010054403A1 (en) | 2008-11-10 | 2010-05-14 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
EP3101031A1 (en) | 2008-11-10 | 2016-12-07 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating complement-associated disorders |
EP2191842A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
EP2191840A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
EP2191841A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
WO2010061357A1 (en) | 2008-11-28 | 2010-06-03 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan |
WO2010061359A1 (en) | 2008-11-28 | 2010-06-03 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically cd38 and cytarabine |
WO2010061358A1 (en) | 2008-11-28 | 2010-06-03 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically cd38 and vincristine |
WO2010061360A1 (en) | 2008-11-28 | 2010-06-03 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically cd38 and cylophosphamide |
EP2191843A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP4169951A1 (en) | 2008-12-09 | 2023-04-26 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP3929216A1 (en) | 2008-12-09 | 2021-12-29 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP4209510A1 (en) | 2008-12-09 | 2023-07-12 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
CN112715482B (en) * | 2008-12-18 | 2022-11-11 | 伊拉兹马斯大学鹿特丹医学中心 | Non-human transgenic animals expressing humanized antibodies and uses thereof |
CN112626117A (en) * | 2008-12-18 | 2021-04-09 | 伊拉兹马斯大学鹿特丹医学中心 | Non-human transgenic animals expressing humanized antibodies and uses thereof |
US9131669B2 (en) | 2008-12-18 | 2015-09-15 | Erasmus University Medical Center | Antibody production |
CN112715482A (en) * | 2008-12-18 | 2021-04-30 | 伊拉兹马斯大学鹿特丹医学中心 | Non-human transgenic animals expressing humanized antibodies and uses thereof |
WO2010070263A1 (en) * | 2008-12-18 | 2010-06-24 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
US11877565B2 (en) | 2008-12-18 | 2024-01-23 | Erasmus University Medical Center | Antibody production |
EP3482769A1 (en) | 2008-12-19 | 2019-05-15 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
EP2786762A2 (en) | 2008-12-19 | 2014-10-08 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
WO2010080538A1 (en) | 2008-12-19 | 2010-07-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
WO2010075548A2 (en) | 2008-12-23 | 2010-07-01 | Genentech, Inc. | Immunoglobulin variants with altered binding to protein a |
WO2010072740A2 (en) | 2008-12-23 | 2010-07-01 | Astrazeneca Ab | TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF |
EP3569620A1 (en) | 2008-12-23 | 2019-11-20 | Amgen Inc. | Human cgrp receptor binding antibodies |
WO2010075238A1 (en) | 2008-12-23 | 2010-07-01 | Amgen Inc. | Human cgrp receptor binding proteins |
EP3318573A1 (en) | 2008-12-23 | 2018-05-09 | F. Hoffmann-La Roche AG | Mmunoglobulin variants with altered binding to protein a |
WO2010078526A1 (en) | 2008-12-31 | 2010-07-08 | Biogen Idec Ma Inc. | Anti-lymphotoxin antibodies |
WO2010082134A1 (en) | 2009-01-14 | 2010-07-22 | Iq Therapeutics Bv | Combination antibodies for the treatment and prevention of disease caused by bacillus anthracis and related bacteria and their toxins |
WO2010085510A1 (en) | 2009-01-20 | 2010-07-29 | Zadeh Homayoun H | Antibody mediated osseous regeneration |
US8852608B2 (en) | 2009-02-02 | 2014-10-07 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
US9499590B2 (en) | 2009-02-02 | 2016-11-22 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
US8309530B2 (en) | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
WO2010093993A2 (en) | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
EP2810652A2 (en) | 2009-03-05 | 2014-12-10 | AbbVie Inc. | IL-17 binding proteins |
EP2772269A2 (en) | 2009-03-05 | 2014-09-03 | Abbvie Inc. | IL-17 binding proteins |
US9663587B2 (en) | 2009-03-05 | 2017-05-30 | Abbvie Inc. | IL-17 binding proteins |
WO2010100247A1 (en) | 2009-03-06 | 2010-09-10 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Novel therapy for anxiety |
EP3088420A1 (en) | 2009-03-20 | 2016-11-02 | F. Hoffmann-La Roche AG | Bispecific anti-her antibodies |
WO2010108153A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
WO2010108127A1 (en) | 2009-03-20 | 2010-09-23 | Genentech, Inc. | Bispecific anti-her antibodies |
EP3385279A1 (en) | 2009-03-20 | 2018-10-10 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
WO2010111180A1 (en) | 2009-03-24 | 2010-09-30 | Teva Biopharmaceuticals Usa, Inc. | Humanized antibodies against light and uses thereof |
US8524869B2 (en) | 2009-03-24 | 2013-09-03 | Teva Biopharmaceuticals Usa, Inc. | Humanized antibodies against LIGHT and uses thereof |
WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
US9849172B2 (en) | 2009-03-30 | 2017-12-26 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
WO2010114859A1 (en) | 2009-04-01 | 2010-10-07 | Genentech, Inc. | Treatment of insulin-resistant disorders |
WO2010118243A2 (en) | 2009-04-08 | 2010-10-14 | Genentech, Inc. | Use of il-27 antagonists to treat lupus |
WO2010117057A1 (en) | 2009-04-10 | 2010-10-14 | 協和発酵キリン株式会社 | Method for treatment of blood tumor using anti-tim-3 antibody |
EP2241323A1 (en) | 2009-04-14 | 2010-10-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Tenascin-W and brain cancers |
EP2918602A1 (en) | 2009-04-16 | 2015-09-16 | AbbVie Biotherapeutics Inc. | Anti-TNF-alpha antibodies and their uses |
US9617600B2 (en) | 2009-04-18 | 2017-04-11 | Genentech, Inc. | Methods for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
WO2010126066A1 (en) | 2009-04-27 | 2010-11-04 | 協和発酵キリン株式会社 | Anti-il-3rα antibody for use in treatment of blood tumor |
EP2949673A1 (en) | 2009-04-27 | 2015-12-02 | Kyowa Hakko Kirin Co., Ltd. | Anti-il-3ra antibody for use in treatment of blood tumor |
WO2010128407A2 (en) | 2009-05-05 | 2010-11-11 | Novimmune S.A. | Anti-il-17f antibodies and methods of use thereof |
US9175069B2 (en) | 2009-05-26 | 2015-11-03 | Icahn School Of Medicine At Mount Sinai | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
EP2894167A1 (en) | 2009-06-17 | 2015-07-15 | AbbVie Biotherapeutics Inc. | Anti-VEGF Antibodies and their uses |
WO2010148223A2 (en) | 2009-06-17 | 2010-12-23 | Facet Biotech Corporation | Anti-vegf antibodies and their uses |
EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
US9504236B2 (en) | 2009-07-08 | 2016-11-29 | Kymab Limited | Animal models and therapeutic molecules |
US11606941B2 (en) | 2009-07-08 | 2023-03-21 | Kymab Limited | Animal models and therapeutic molecules |
US11812731B2 (en) | 2009-07-08 | 2023-11-14 | Kymab Ltd. | Animal models and therapeutic molecules |
US9505827B2 (en) | 2009-07-08 | 2016-11-29 | Kymab Limited | Animal models and therapeutic molecules |
US9434782B2 (en) | 2009-07-08 | 2016-09-06 | Kymab Limited | Animal models and therapeutic molecules |
US10165763B2 (en) | 2009-07-08 | 2019-01-01 | Kymab Limited | Animal models and therapeutic molecules |
US10064398B2 (en) | 2009-07-08 | 2018-09-04 | Kymab Limited | Animal models and therapeutic molecules |
US9447177B2 (en) | 2009-07-08 | 2016-09-20 | Kymab Limited | Transgenic mouse homozygous for chimeric IgH locus |
WO2011006001A1 (en) | 2009-07-09 | 2011-01-13 | Genentech, Inc. | Animal model for the evaluation of adjuvant therapies of cancer |
WO2011008696A2 (en) | 2009-07-13 | 2011-01-20 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2011014457A1 (en) | 2009-07-27 | 2011-02-03 | Genentech, Inc. | Combination treatments |
WO2011014504A1 (en) | 2009-07-27 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Recombinant influenza virus vectors and uses thereof |
WO2011014645A1 (en) | 2009-07-30 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Influenza viruses and uses thereof |
WO2011014750A1 (en) | 2009-07-31 | 2011-02-03 | Genentech, Inc. | Inhibition of tumor metastasis using bv8- or g-csf-antagonists |
WO2011019620A1 (en) | 2009-08-10 | 2011-02-17 | Genentech, Inc. | Antibodies with enhanced adcc function |
EP3760712A1 (en) | 2009-08-11 | 2021-01-06 | F. Hoffmann-La Roche AG | Production of proteins in glutamine-free cell culture media |
US10982003B2 (en) | 2009-08-11 | 2021-04-20 | Genentech, Inc. | Production of proteins in glutamine-free cell culture media |
WO2011019619A1 (en) | 2009-08-11 | 2011-02-17 | Genentech, Inc. | Production of proteins in glutamine-free cell culture media |
US8512983B2 (en) | 2009-08-11 | 2013-08-20 | Martin Gawlitzek | Production of proteins in glutamine-free cell culture media |
US9714293B2 (en) | 2009-08-11 | 2017-07-25 | Genentech, Inc. | Production of proteins in glutamine-free cell culture media |
WO2011020079A1 (en) | 2009-08-13 | 2011-02-17 | Calmune Corporation | Antibodies against human respiratory syncytial virus (rsv) and methods of use |
US8568719B2 (en) | 2009-08-13 | 2013-10-29 | Crucell Holland B.V. | Antibodies against human respiratory syncytial virus (RSV) and methods of use |
US9365638B2 (en) | 2009-08-13 | 2016-06-14 | Crucell Holland B. V. | Antibodies against human respiratory syncytial virus (RSV) and methods of use |
US9988437B2 (en) | 2009-08-13 | 2018-06-05 | Janssen Vaccines & Prevention B.V. | Anti-human Respiratory Syncytial Virus (RSV) antibodies and methods of use |
WO2011020049A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Biological markers for monitoring patient response to vegf antagonists |
WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
EP2292266A1 (en) | 2009-08-27 | 2011-03-09 | Novartis Forschungsstiftung, Zweigniederlassung | Treating cancer by modulating copine III |
US9132190B2 (en) | 2009-08-29 | 2015-09-15 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
US8623358B2 (en) | 2009-08-29 | 2014-01-07 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
US9469688B2 (en) | 2009-08-29 | 2016-10-18 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
EP3029070A1 (en) | 2009-08-29 | 2016-06-08 | AbbVie Inc. | Therapeutic dll4 binding proteins |
WO2011025964A2 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
US8586714B2 (en) | 2009-09-01 | 2013-11-19 | Abbvie, Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2011028950A1 (en) | 2009-09-02 | 2011-03-10 | Genentech, Inc. | Mutant smoothened and methods of using the same |
EP3211094A2 (en) | 2009-09-03 | 2017-08-30 | F. Hoffmann-La Roche AG | Methods for treating, diagnosing, and monitoring rheumatoid arthritis |
AU2010292342B2 (en) * | 2009-09-09 | 2015-04-30 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human protease-activated receptor-2 |
US9028819B2 (en) | 2009-09-09 | 2015-05-12 | Regeneron Pharmaceuticals, Inc. | Methods of alleviating itch by administering human antibodies to human protease-activated receptor 2 |
AU2010292342C1 (en) * | 2009-09-09 | 2015-08-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human protease-activated receptor-2 |
WO2011032013A1 (en) | 2009-09-11 | 2011-03-17 | Genentech, Inc. | Method to identify a patient with an increased likelihood of responding to an anti-cancer agent |
US8557239B2 (en) | 2009-09-14 | 2013-10-15 | Abbvie Inc. | Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23 |
WO2011033006A1 (en) | 2009-09-17 | 2011-03-24 | F. Hoffmann-La Roche Ag | Methods and compositions for diagnostics use in cancer patients |
WO2011036118A1 (en) | 2009-09-22 | 2011-03-31 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mex-3 |
EP3187877A1 (en) | 2009-09-25 | 2017-07-05 | XOMA Technology Ltd. | Screening methods |
WO2011038301A2 (en) | 2009-09-25 | 2011-03-31 | Xoma Technology Ltd. | Screening methods |
WO2011038302A2 (en) | 2009-09-25 | 2011-03-31 | Xoma Technology Ltd. | Novel modulators |
EP2957296A1 (en) | 2009-09-25 | 2015-12-23 | Xoma (Us) Llc | Insulin receptor binding antibodies |
EP2483309A4 (en) * | 2009-09-29 | 2013-07-17 | Green Cross Corp | Antibodies specifically binding to the epidermal growth factor receptor |
US8748175B2 (en) | 2009-09-29 | 2014-06-10 | Green Cross Corporation | Antibodies specifically binding to the epidermal growth factor receptor |
EP2483309A1 (en) * | 2009-09-29 | 2012-08-08 | Green Cross Corporation | Antibodies specifically binding to the epidermal growth factor receptor |
WO2011041336A2 (en) | 2009-09-30 | 2011-04-07 | Genentech, Inc. | Methods of treating cancer using notch antagonists |
WO2011039724A1 (en) | 2009-10-02 | 2011-04-07 | Sanofi-Aventis | Antibodies that specifically bind to the epha2 receptor |
US8668910B2 (en) | 2009-10-02 | 2014-03-11 | Sanofi | Antibodies that specifically bind to the EphA2 receptor |
US9676864B2 (en) | 2009-10-02 | 2017-06-13 | Sanofi | Antibodies that specifically bind to the EphA2 receptor |
US10053734B2 (en) | 2009-10-07 | 2018-08-21 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
EP3219813A2 (en) | 2009-10-07 | 2017-09-20 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
EP3839068A2 (en) | 2009-10-07 | 2021-06-23 | F. Hoffmann-La Roche AG | Methods for treating, diagnosing, and monitoring lupus |
WO2011044205A1 (en) | 2009-10-07 | 2011-04-14 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
WO2011044368A1 (en) | 2009-10-07 | 2011-04-14 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
WO2011049758A1 (en) | 2009-10-09 | 2011-04-28 | Amgen Inc. | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors |
EP3028717A1 (en) | 2009-10-09 | 2016-06-08 | Amgen, Inc | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors |
US8716450B2 (en) | 2009-10-15 | 2014-05-06 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2011045352A2 (en) | 2009-10-15 | 2011-04-21 | Novartis Forschungsstiftung | Spleen tyrosine kinase and brain cancers |
EP3656790A1 (en) | 2009-10-26 | 2020-05-27 | Amgen, Inc | Human il-23 antigen binding proteins |
US9487580B2 (en) | 2009-10-26 | 2016-11-08 | Amgen Inc. | Human IL-23 antigen binding proteins |
WO2011056502A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Bone morphogenetic protein receptor type ii compositions and methods of use |
US9951129B2 (en) | 2009-10-26 | 2018-04-24 | Amgen Inc. | Human IL-23 antigen binding proteins |
WO2011056600A1 (en) | 2009-10-26 | 2011-05-12 | Amgen Inc. | Human il-23 antigen binding proteins |
WO2011056494A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
EP3181586A1 (en) | 2009-10-26 | 2017-06-21 | Amgen, Inc | Human il-23 antigen binding proteins |
US9315583B2 (en) | 2009-10-26 | 2016-04-19 | Genentech, Inc. | Assays for detecting antibodies specific to therapeutic anti-IgE antibodies and their use in anaphylaxis |
WO2011056497A1 (en) | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor type iib compositions and methods of use |
WO2011059762A1 (en) | 2009-10-28 | 2011-05-19 | Abbott Biotherapeutics Corp. | Anti-egfr antibodies and their uses |
US8722855B2 (en) | 2009-10-28 | 2014-05-13 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2011051392A1 (en) | 2009-10-30 | 2011-05-05 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Phosphorylated twist1 and cancer |
US8420083B2 (en) | 2009-10-31 | 2013-04-16 | Abbvie Inc. | Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof |
US9067996B2 (en) | 2009-10-31 | 2015-06-30 | Abbvie Inc. | Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof |
WO2011056073A2 (en) | 2009-11-04 | 2011-05-12 | Erasmus University Medical Center Rotterdam | Novel compounds for modulating neovascularisation and methods of treatment using these compounds |
WO2011058321A1 (en) | 2009-11-11 | 2011-05-19 | King's College Hospital Nhs Foundation Trust | Conjugate molecule |
WO2011060015A1 (en) | 2009-11-11 | 2011-05-19 | Genentech, Inc. | Methods and compositions for detecting target proteins |
EP2896632A2 (en) | 2009-11-13 | 2015-07-22 | U3 Pharma GmbH | Material and methods for treating or preventing HER-3 associated diseases |
US9101760B2 (en) | 2009-11-13 | 2015-08-11 | U3 Pharma Gmbh | Material and methods for treating or preventing HER-3 associated diseases |
EP3670539A1 (en) | 2009-11-13 | 2020-06-24 | Daiichi Sankyo Europe GmbH | Material and methods for treating or preventing her-3 associated diseases |
EP2719708A2 (en) | 2009-11-13 | 2014-04-16 | U3 Pharma GmbH | Material and methods for treating or preventing HER-3 associated diseases |
EP3351558A2 (en) | 2009-11-13 | 2018-07-25 | Daiichi Sankyo Europe GmbH | Material and methods for treating or preventing her-3 associated diseases |
US9803025B2 (en) | 2009-11-13 | 2017-10-31 | Amgen, Inc. | Material and methods for treating or preventing HER-3 associated diseases |
WO2011060206A2 (en) | 2009-11-13 | 2011-05-19 | U3 Pharma Gmbh | Material and methods for treating or preventing her-3 associated diseases |
EP3037435A1 (en) | 2009-11-17 | 2016-06-29 | MUSC Foundation For Research Development | Human monoclonal antibodies to human nucleolin |
US10385128B2 (en) | 2009-11-17 | 2019-08-20 | Musc Foundation For Research Development | Nucleolin antibodies |
US9260517B2 (en) | 2009-11-17 | 2016-02-16 | Musc Foundation For Research Development | Human monoclonal antibodies to human nucleolin |
WO2011063277A1 (en) | 2009-11-20 | 2011-05-26 | Amgen Inc. | Anti-orai1 antigen binding proteins and uses thereof |
EP3279215A1 (en) | 2009-11-24 | 2018-02-07 | MedImmune Limited | Targeted binding agents against b7-h1 |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US11267870B2 (en) | 2009-12-02 | 2022-03-08 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
EP2711375A1 (en) | 2009-12-07 | 2014-03-26 | Amgen Inc. | Human Antigen Binding Proteins that bind Beta-Klotho, FGF Receptors and complexes thereof |
EP3760642A1 (en) | 2009-12-07 | 2021-01-06 | Amgen Inc. | Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof |
EP3202787A1 (en) | 2009-12-07 | 2017-08-09 | Amgen, Inc | Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof |
WO2011071783A1 (en) | 2009-12-07 | 2011-06-16 | Amgen Inc. | Human antigen binding proteins that bind beta-klotho, fgf receptors and complexes thereof |
WO2011070045A1 (en) | 2009-12-08 | 2011-06-16 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
US9175075B2 (en) | 2009-12-08 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Methods of treating retinal nerve fiber layer degeneration with monoclonal antibodies against a retinal guidance molecule (RGM) protein |
WO2011071577A1 (en) | 2009-12-11 | 2011-06-16 | Genentech, Inc. | Anti-vegf-c antibodies and methods using same |
WO2011084496A1 (en) | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
WO2011084750A1 (en) | 2009-12-21 | 2011-07-14 | Genentech, Inc. | Antibody formulation |
US11020495B2 (en) | 2009-12-21 | 2021-06-01 | Regeneron Pharmaceuticals, Inc. | Humanized low affinity FCγR mouse cells |
EP2516457B1 (en) | 2009-12-21 | 2018-03-14 | Regeneron Pharmaceuticals, Inc. | Humanized fc gamma r mice |
EP3616719A1 (en) | 2009-12-21 | 2020-03-04 | F. Hoffmann-La Roche AG | Antibody formulation |
US10426848B2 (en) | 2009-12-21 | 2019-10-01 | Regeneron Pharmaceuticals, Inc. | Humanized FcγR mice |
WO2011079185A1 (en) | 2009-12-23 | 2011-06-30 | Genentech, Inc. | Anti-bv8 antibodies and uses thereof |
WO2011085343A1 (en) | 2010-01-11 | 2011-07-14 | Alexion Pharmaceuticals, Inc | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
US10412940B2 (en) | 2010-02-08 | 2019-09-17 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
US11026407B2 (en) | 2010-02-08 | 2021-06-08 | Regeneran Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US10167344B2 (en) | 2010-02-08 | 2019-01-01 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US9969814B2 (en) | 2010-02-08 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | Methods for making fully human bispecific antibodies using a common light chain |
US10986820B2 (en) | 2010-02-08 | 2021-04-27 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
EP3680253A2 (en) | 2010-03-02 | 2020-07-15 | AbbVie Inc. | Therapeutic dll4 binding proteins |
EP3072904A1 (en) | 2010-03-02 | 2016-09-28 | Abbvie Inc. | Therapeutic dll4 binding proteins |
US9115195B2 (en) | 2010-03-02 | 2015-08-25 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
US9469689B2 (en) | 2010-03-02 | 2016-10-18 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
WO2011107586A1 (en) | 2010-03-05 | 2011-09-09 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research, | Smoc1, tenascin-c and brain cancers |
US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
EP3900740A1 (en) | 2010-03-30 | 2021-10-27 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
US10179806B2 (en) | 2010-03-30 | 2019-01-15 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
EP3248615A1 (en) | 2010-03-30 | 2017-11-29 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
US10526420B2 (en) | 2010-03-31 | 2020-01-07 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US11104743B2 (en) | 2010-03-31 | 2021-08-31 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US11220555B2 (en) | 2010-03-31 | 2022-01-11 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US11104744B2 (en) | 2010-03-31 | 2021-08-31 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US11242409B2 (en) | 2010-03-31 | 2022-02-08 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10662255B2 (en) | 2010-03-31 | 2020-05-26 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10604587B2 (en) | 2010-03-31 | 2020-03-31 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10494445B2 (en) | 2010-03-31 | 2019-12-03 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10829564B2 (en) | 2010-03-31 | 2020-11-10 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10626188B2 (en) | 2010-03-31 | 2020-04-21 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US11352444B2 (en) | 2010-03-31 | 2022-06-07 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10618977B2 (en) | 2010-03-31 | 2020-04-14 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10836832B2 (en) | 2010-03-31 | 2020-11-17 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
WO2011130377A2 (en) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Amyloid-beta binding proteins |
EP3670534A2 (en) | 2010-04-15 | 2020-06-24 | Amgen Inc. | Human fgf receptor and beta-klotho binding proteins |
US9822171B2 (en) | 2010-04-15 | 2017-11-21 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
WO2011130417A2 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS |
WO2011131611A1 (en) | 2010-04-19 | 2011-10-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Modulating xrn1 |
WO2011133931A1 (en) | 2010-04-22 | 2011-10-27 | Genentech, Inc. | Use of il-27 antagonists for treating inflammatory bowel disease |
US9309310B2 (en) | 2010-04-30 | 2016-04-12 | Alexion Pharmaceuticals, Inc. | Nucleic acids encoding anti-C5a antibodies |
US9221901B2 (en) | 2010-04-30 | 2015-12-29 | Alexion Pharmaceuticals, Inc. | Methods of treating complement-associated disorders with anti-C5a antibodies |
US11407821B2 (en) | 2010-04-30 | 2022-08-09 | Alexion Pharmaceuticals, Inc. | Anti-C5A antibodies |
US9469690B2 (en) | 2010-04-30 | 2016-10-18 | Alexion Pharmaceuticals, Inc. | Methods of treating complement-associated disorders with anti-C5a antibodies |
US10450370B2 (en) | 2010-04-30 | 2019-10-22 | Alexion Pharmaceuticals, Inc. | Anti-C5a antibodies |
US9371378B1 (en) | 2010-04-30 | 2016-06-21 | Alexion Pharmaceuticals, Inc. | Anti-C5a antibodies |
US9963503B2 (en) | 2010-04-30 | 2018-05-08 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-C5a antibodies |
US9434784B1 (en) | 2010-04-30 | 2016-09-06 | Alexion Pharmaceuticals, Inc. | Nucleic acids encodng anti-C5A antibodies |
EP2824111A2 (en) | 2010-04-30 | 2015-01-14 | Alexion Pharmaceuticals, Inc. | Anti-C5A Antibodies and Methods for Using the Antibodies |
WO2011137395A1 (en) | 2010-04-30 | 2011-11-03 | Rother Russell P | Anti-c5a antibodies and methods for using the antibodies |
WO2011138776A2 (en) | 2010-05-06 | 2011-11-10 | Hervana Ltd. | Biologic female contraceptives |
US9403855B2 (en) | 2010-05-10 | 2016-08-02 | Academia Sinica | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
US9874562B2 (en) | 2010-05-10 | 2018-01-23 | Academia Sinica | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
WO2011141823A2 (en) | 2010-05-14 | 2011-11-17 | Orega Biotech | Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists |
WO2011143562A2 (en) | 2010-05-14 | 2011-11-17 | Abbott Laboratories | Il-1 binding proteins |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
WO2011153224A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2011153346A1 (en) | 2010-06-03 | 2011-12-08 | Genentech, Inc. | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
US8771966B2 (en) | 2010-06-03 | 2014-07-08 | Genentech, Inc. | Immuno-PET imaging of antibodies and immunoconjugates and uses therefor |
WO2011154485A1 (en) | 2010-06-10 | 2011-12-15 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mammalian sterile 20-like kinase 3 |
EP3323830A1 (en) | 2010-06-19 | 2018-05-23 | Memorial Sloan-Kettering Cancer Center | Anti-gd2 antibodies |
EP4269563A2 (en) | 2010-06-19 | 2023-11-01 | Memorial Sloan-Kettering Cancer Center | Anti-gd2 antibodies |
USRE49339E1 (en) | 2010-06-22 | 2022-12-20 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3D fragment of complement component 3 |
US9815890B2 (en) | 2010-06-22 | 2017-11-14 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3d fragment of complement component 3 |
WO2011161427A2 (en) | 2010-06-25 | 2011-12-29 | Aston University | Glycoproteins having lipid mobilizing properties and therapeutic uses thereof |
EP3459558A1 (en) | 2010-06-25 | 2019-03-27 | Aston University | Glycoproteins having lipid mobilizing properties and therapeutic uses thereof |
WO2012012141A1 (en) | 2010-06-30 | 2012-01-26 | Amgen Inc. | Scnn1a/tnfrsf1a fusion proteins in cancer |
WO2012006500A2 (en) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Monoclonal antibodies against hepatitis c virus core protein |
WO2012006596A2 (en) | 2010-07-09 | 2012-01-12 | Calmune Corporation | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
EP2921177A2 (en) | 2010-07-09 | 2015-09-23 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
WO2012010547A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010549A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010548A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2801826A1 (en) | 2010-07-19 | 2014-11-12 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2848940A1 (en) | 2010-07-19 | 2015-03-18 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2848939A1 (en) | 2010-07-19 | 2015-03-18 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2824457A1 (en) | 2010-07-19 | 2015-01-14 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
EP2866032A1 (en) | 2010-07-19 | 2015-04-29 | F. Hoffmann-La Roche AG | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010550A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010551A1 (en) | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
WO2012010855A1 (en) | 2010-07-23 | 2012-01-26 | Medical Research Council | Intracellular immunity |
WO2012010321A1 (en) | 2010-07-23 | 2012-01-26 | Erasmus University Medical Center Rotterdam | Foetal haemoglobin inhibitor |
US9516868B2 (en) | 2010-08-02 | 2016-12-13 | Regeneron Pharmaceuticals, Inc. | Mice that make VL binding proteins |
US10954310B2 (en) | 2010-08-02 | 2021-03-23 | Regeneran Pharmaceuticals, Inc. | Mice that make VL binding proteins |
WO2012018687A1 (en) | 2010-08-02 | 2012-02-09 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9686970B2 (en) | 2010-08-02 | 2017-06-27 | Regeneron Pharmaceuticals, Inc. | Mice that make VL binding proteins |
EP3252072A2 (en) | 2010-08-03 | 2017-12-06 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
US9493560B2 (en) | 2010-08-03 | 2016-11-15 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2012018404A2 (en) | 2010-08-06 | 2012-02-09 | U3 Pharma Gmbh | Use of her3 binding agents in prostate treatment |
WO2012021648A1 (en) | 2010-08-10 | 2012-02-16 | Amgen Inc. | Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies |
US10047121B2 (en) | 2010-08-14 | 2018-08-14 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US10125192B2 (en) | 2010-08-19 | 2018-11-13 | Zoetis Belgium S.A. | Caninized anti-NGF antibodies and their use |
WO2012024650A2 (en) | 2010-08-19 | 2012-02-23 | Abbott Laboratories | Anti-ngf antibodies and their use |
EP3333188A1 (en) | 2010-08-19 | 2018-06-13 | Zoetis Belgium S.A. | Anti-ngf antibodies and their use |
EP4056589A1 (en) | 2010-08-19 | 2022-09-14 | Zoetis Belgium S.A. | Anti-ngf antibodies and their use |
US10093725B2 (en) | 2010-08-19 | 2018-10-09 | Zoetis Belgium S.A. | Anti-NGF antibodies and their use |
US9505829B2 (en) | 2010-08-19 | 2016-11-29 | Zoetis Belgium S.A. | Anti-NGF antibodies and their use |
US9046513B2 (en) | 2010-08-26 | 2015-06-02 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
WO2012032143A1 (en) | 2010-09-10 | 2012-03-15 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Phosphorylated twist1 and metastasis |
WO2012040518A2 (en) | 2010-09-22 | 2012-03-29 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
WO2012047968A2 (en) | 2010-10-05 | 2012-04-12 | Genentech, Inc. | Mutant smoothened and methods of using the same |
WO2012054748A2 (en) | 2010-10-22 | 2012-04-26 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
EP3581206A1 (en) | 2010-10-22 | 2019-12-18 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the p13k-akt mtor pathway |
EP3219725A2 (en) | 2010-10-27 | 2017-09-20 | Amgen, Inc | Dkk1 antibodies and methods of use |
EP3838922A1 (en) | 2010-10-27 | 2021-06-23 | Amgen Inc. | Dkk1 antibodies and methods of use |
WO2012058393A2 (en) | 2010-10-27 | 2012-05-03 | Amgen Inc. | Dkk1 antibodies and methods of use |
US10800839B2 (en) | 2010-10-27 | 2020-10-13 | Amgen Inc. | DKK1 antibodies and methods of use |
WO2012065937A1 (en) | 2010-11-15 | 2012-05-24 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Anti-fungal agents |
WO2012071381A1 (en) | 2010-11-24 | 2012-05-31 | Lexicon Pharmaceuticals, Inc. | Antibodies to notum pectinacetylesterase |
US9314522B2 (en) | 2010-12-10 | 2016-04-19 | Sanofi | Antitumors combinations containing antibodies recognizing specifically CD38 and bortezomib |
WO2012076663A1 (en) | 2010-12-10 | 2012-06-14 | Sanofi | Antitumor combinations containing antibodies recognizing specifically cd38 and bortezomib |
WO2012121775A2 (en) | 2010-12-21 | 2012-09-13 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
WO2012088094A2 (en) | 2010-12-21 | 2012-06-28 | Abbott Laboratories | Il-1 binding proteins |
WO2012083370A1 (en) | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
WO2012094252A1 (en) | 2011-01-03 | 2012-07-12 | The Terasaki Family Foundation | Anti-hla-e antibodies, therapeutic immunomodulatory antibodies to human hla-e heavy chain, useful as ivig mimetics and methods of their use |
WO2012099983A1 (en) | 2011-01-18 | 2012-07-26 | Amgen Inc. | Nav1.7 knockout mice and uses thereof |
WO2012102679A1 (en) | 2011-01-24 | 2012-08-02 | National University Of Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
WO2012103165A2 (en) | 2011-01-26 | 2012-08-02 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
EP3763740A1 (en) | 2011-01-26 | 2021-01-13 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
WO2012106634A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
US10694725B2 (en) | 2011-02-25 | 2020-06-30 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US10905109B2 (en) | 2011-02-25 | 2021-02-02 | Regeneren Pharmaceuticals, Inc. | ADAM6 mice |
US11950578B2 (en) | 2011-02-25 | 2024-04-09 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US10905108B2 (en) | 2011-02-25 | 2021-02-02 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US9944716B2 (en) | 2011-02-25 | 2018-04-17 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US8697940B2 (en) | 2011-02-25 | 2014-04-15 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US8642835B2 (en) | 2011-02-25 | 2014-02-04 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US9932408B2 (en) | 2011-02-25 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
US10577430B2 (en) | 2011-02-25 | 2020-03-03 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
WO2012118750A2 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
WO2012118903A2 (en) | 2011-03-01 | 2012-09-07 | Amgen Inc. | Bispecific binding agents |
US11008389B2 (en) | 2011-03-16 | 2021-05-18 | Sanofi | Uses of a dual V region antibody-like protein |
WO2012128377A1 (en) | 2011-03-18 | 2012-09-27 | 国立大学法人鹿児島大学 | Composition for treatment and diagnosis of pancreatic cancer |
WO2012138997A1 (en) | 2011-04-07 | 2012-10-11 | Amgen Inc. | Novel egfr binding proteins |
US8628773B2 (en) | 2011-04-07 | 2014-01-14 | Amgen Inc. | Antigen binding proteins |
US9676846B2 (en) | 2011-04-12 | 2017-06-13 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
EP3403672A1 (en) | 2011-04-20 | 2018-11-21 | Medlmmune, LLC | Antibodies and other molecules that bind b7-h1 and pd-1 |
WO2012145493A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
US9205148B2 (en) | 2011-04-20 | 2015-12-08 | Medimmune, Llc | Antibodies and other molecules that bind B7-H1 and PD-1 |
US9255143B2 (en) | 2011-04-27 | 2016-02-09 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9505834B2 (en) | 2011-04-27 | 2016-11-29 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9365645B1 (en) | 2011-04-27 | 2016-06-14 | Abbvie, Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9090688B2 (en) | 2011-04-27 | 2015-07-28 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
EP3597218A1 (en) | 2011-05-10 | 2020-01-22 | Amgen, Inc | Methods of treating or preventing cholesterol related disorders |
WO2012154999A1 (en) | 2011-05-10 | 2012-11-15 | Amgen Inc. | Methods of treating or preventing cholesterol related disorders |
US11013800B2 (en) | 2011-05-16 | 2021-05-25 | Evive Biotech Ltd. | Multi-specific Fab fusion proteins comprising a CD3-binding Fab fragment with N-terminal fusion to binding domains and methods of use |
EP3623381A1 (en) | 2011-05-19 | 2020-03-18 | The Regents Of The University Of Michigan | Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation |
US8975029B2 (en) | 2011-05-19 | 2015-03-10 | The Regents Of The University Of Michigan | Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation |
WO2012162068A2 (en) | 2011-05-21 | 2012-11-29 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
WO2012162531A1 (en) | 2011-05-25 | 2012-11-29 | Bg Medicine, Inc. | Inhibitors of galectin-3 and methods of use thereof |
US11344633B2 (en) | 2011-06-02 | 2022-05-31 | University Of Louisville Research Foundation, Inc | Anti-nucleolin agent-conjugated nanoparticles |
US9452219B2 (en) | 2011-06-02 | 2016-09-27 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles |
WO2012167143A1 (en) | 2011-06-03 | 2012-12-06 | Xoma Technology Ltd. | Antibodies specific for tgf-beta |
EP3954704A1 (en) | 2011-06-03 | 2022-02-16 | XOMA Technology Ltd. | Antibodies specific for tgf-beta |
US10882916B2 (en) | 2011-06-06 | 2021-01-05 | Novo Nordisk A/S | Anti-C5a receptor antibodies |
WO2012168259A1 (en) | 2011-06-06 | 2012-12-13 | Novartis Forschungsstiftung, Zweigniederlassung | Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer |
US9181553B2 (en) | 2011-06-06 | 2015-11-10 | Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Method of treatment of breast cancers over-expressing the SHP2 signature genes |
WO2012170438A2 (en) | 2011-06-06 | 2012-12-13 | Amgen Inc. | HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING β-KLOTHO AND AN FGF RECEPTOR |
US9574002B2 (en) | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
WO2012170071A1 (en) | 2011-06-06 | 2012-12-13 | Elan Pharmaceuticas, Inc | Mcam antagonists and methods of treatment |
US10323097B2 (en) | 2011-06-06 | 2019-06-18 | Novo Nordisk A/S | Anti-C5a receptor antibodies |
US8846045B2 (en) | 2011-06-06 | 2014-09-30 | Novo Nordisk A/S | Anti-C5a receptor antibodies |
US8613926B2 (en) | 2011-06-06 | 2013-12-24 | Novo Nordisk A/S | Anti-C5a receptor antibodies |
EP3447074A2 (en) | 2011-06-06 | 2019-02-27 | Amgen, Inc | Human antigen binding proteins that bind to a complex comprising beta-klotho and an fgf receptor |
US11248052B2 (en) | 2011-06-06 | 2022-02-15 | Amgen Inc. | Antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
EP3385280A1 (en) | 2011-06-10 | 2018-10-10 | MedImmune Limited | Anti-pseudomonas psl binding molecules and uses thereof |
WO2012174534A2 (en) | 2011-06-17 | 2012-12-20 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using clec-2 |
WO2012175576A1 (en) | 2011-06-20 | 2012-12-27 | Pierre Fabre Medicament | Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer. |
US9562097B2 (en) | 2011-07-01 | 2017-02-07 | Genentech, Inc. | Use of anti-CD83 agonist antibodies for treating autoimmune diseases |
EP3574919A1 (en) | 2011-07-13 | 2019-12-04 | AbbVie Inc. | Methods and compositions for treating asthma using anti-il-13 antibodies |
US9724413B2 (en) | 2011-08-01 | 2017-08-08 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
US10646567B2 (en) | 2011-08-01 | 2020-05-12 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
WO2013019906A1 (en) | 2011-08-01 | 2013-02-07 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
US11357217B2 (en) | 2011-08-05 | 2022-06-14 | Regeneron Pharmaceuticals, Inc. | Humanized universal light chain mice |
US10130081B2 (en) | 2011-08-05 | 2018-11-20 | Regeneron Pharmaceuticals, Inc. | Humanized universal light chain mice |
WO2013025779A1 (en) | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
WO2013025944A1 (en) | 2011-08-17 | 2013-02-21 | Genentech, Inc. | Inhibition of angiogenesis in refractory tumors |
WO2013034660A1 (en) | 2011-09-09 | 2013-03-14 | Medimmune Limited | Anti-siglec-15 antibodies and uses thereof |
WO2013066491A1 (en) | 2011-09-09 | 2013-05-10 | Amgen Inc. | Use of human papillomavirus status in establishing use of an agent that binds egfr in the treatment of cancer |
EP2757875A2 (en) | 2011-09-19 | 2014-07-30 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US11051497B2 (en) | 2011-09-19 | 2021-07-06 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
EP2757875B1 (en) | 2011-09-19 | 2017-11-29 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
EP3311661B1 (en) | 2011-09-19 | 2022-04-20 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US10131695B2 (en) | 2011-09-20 | 2018-11-20 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
EP4241785A2 (en) | 2011-09-20 | 2023-09-13 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
WO2013042426A1 (en) | 2011-09-21 | 2013-03-28 | 富士レビオ株式会社 | Antibody against affinity complex |
US9963716B2 (en) | 2011-09-26 | 2018-05-08 | Kymab Limited | Chimaeric surrogate light chains (SLC) comprising human VpreB |
US10793633B2 (en) | 2011-09-30 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
WO2013052155A1 (en) | 2011-10-05 | 2013-04-11 | Genentech, Inc. | Methods of treating liver conditions using notch2 antagonists |
US10246509B2 (en) | 2011-10-17 | 2019-04-02 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
US9932398B2 (en) | 2011-10-17 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
US11261248B2 (en) | 2011-10-17 | 2022-03-01 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
WO2013063114A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against tnf |
WO2013063095A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against sclerostin |
US11219195B2 (en) | 2011-10-28 | 2022-01-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US10045516B2 (en) | 2011-10-28 | 2018-08-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US10219493B2 (en) | 2011-10-28 | 2019-03-05 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US9585373B2 (en) | 2011-10-28 | 2017-03-07 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US9615550B2 (en) | 2011-10-28 | 2017-04-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
US10779520B2 (en) | 2011-10-28 | 2020-09-22 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US10986822B2 (en) | 2011-10-28 | 2021-04-27 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US9700025B2 (en) | 2011-10-28 | 2017-07-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
US10869466B2 (en) | 2011-10-28 | 2020-12-22 | Regeneran Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US9113616B2 (en) | 2011-10-28 | 2015-08-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice having humanized TCR variable genes |
US8847005B2 (en) | 2011-10-28 | 2014-09-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US11528895B2 (en) | 2011-10-28 | 2022-12-20 | Regeneron Pharmaceuticals, Inc. | Genetically modified T cell receptor mice |
EP3091029A1 (en) | 2011-10-31 | 2016-11-09 | F. Hoffmann-La Roche AG | Anti-il13 antibody formulations |
EP4218937A2 (en) | 2011-10-31 | 2023-08-02 | F. Hoffmann-La Roche AG | Anti-il13 antibody formulations |
WO2013067060A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
WO2013067054A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Antibodies and methods of treating cancer |
WO2013067057A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
WO2013067055A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
US10196442B2 (en) | 2011-11-01 | 2019-02-05 | Bionomics Inc. | Methods of inhibiting growth of a colon cancer tumor in a subject by administering monoclonal antibodies to G protein-coupled receptor 49 (GPR49) |
US10598653B2 (en) | 2011-11-01 | 2020-03-24 | Bionomics Inc. | Methods of blocking cancer stem cell growth |
US10259849B2 (en) | 2011-11-03 | 2019-04-16 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
WO2013067492A1 (en) | 2011-11-03 | 2013-05-10 | The Trustees Of The University Of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
US9279008B2 (en) | 2011-11-03 | 2016-03-08 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
US10961288B2 (en) | 2011-11-03 | 2021-03-30 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
US9422351B2 (en) | 2011-11-03 | 2016-08-23 | The Trustees Of The University Of Pennsylvania | Isolated B7-H4 specific compositions and methods of use thereof |
WO2013068431A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
WO2013068432A1 (en) | 2011-11-08 | 2013-05-16 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research | Early diagnostic of neurodegenerative diseases |
WO2013068902A1 (en) | 2011-11-08 | 2013-05-16 | Pfizer Inc. | Methods of treating inflammatory disorders using anti-m-csf antibodies |
WO2013070821A1 (en) | 2011-11-08 | 2013-05-16 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
US9790267B2 (en) | 2011-11-08 | 2017-10-17 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
WO2013075048A1 (en) | 2011-11-16 | 2013-05-23 | Amgen Inc. | Methods of treating epidermal growth factor deletion mutant viii related disorders |
EP3763741A1 (en) | 2011-11-28 | 2021-01-13 | Merck Patent GmbH | Anti-pd-l1 antibodies and uses thereof |
WO2013079174A1 (en) | 2011-11-28 | 2013-06-06 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
US10117932B2 (en) | 2011-12-08 | 2018-11-06 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
WO2013086443A1 (en) | 2011-12-08 | 2013-06-13 | Amgen Inc. | Agonistic human lcat antigen binding proteins and their use in therapy |
WO2013083817A1 (en) | 2011-12-08 | 2013-06-13 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
WO2013090633A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
EP3800200A1 (en) | 2011-12-14 | 2021-04-07 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
US10822403B2 (en) | 2011-12-14 | 2020-11-03 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
WO2013090635A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
US10118958B2 (en) | 2011-12-14 | 2018-11-06 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
US9636398B2 (en) | 2011-12-14 | 2017-05-02 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
EP3050900A1 (en) | 2011-12-19 | 2016-08-03 | Xoma (Us) Llc | Methods for treating acne |
WO2013096516A1 (en) | 2011-12-19 | 2013-06-27 | Xoma Technology Ltd. | Methods for treating acne |
US11617357B2 (en) | 2011-12-20 | 2023-04-04 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
US10561124B2 (en) | 2011-12-20 | 2020-02-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
US9622459B2 (en) | 2011-12-20 | 2017-04-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
US11612151B2 (en) | 2011-12-20 | 2023-03-28 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
US9706759B2 (en) | 2011-12-20 | 2017-07-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
WO2013093809A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
US9120870B2 (en) | 2011-12-30 | 2015-09-01 | Abbvie Inc. | Dual specific binding proteins directed against IL-13 and IL-17 |
WO2013102825A1 (en) | 2012-01-02 | 2013-07-11 | Novartis Ag | Cdcp1 and breast cancer |
WO2013106485A2 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
WO2013106489A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
EP3663314A1 (en) | 2012-01-09 | 2020-06-10 | The Scripps Research Institute | Humanized antibodies with ultralong cdr3s |
WO2013106586A2 (en) | 2012-01-11 | 2013-07-18 | The Terasaki Family Foundation | Anti-hla class-ib antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (ivig) useful as therapeutic ivig mimetics and methods of their use |
US10800847B2 (en) | 2012-01-11 | 2020-10-13 | Dr. Mepur Ravindranath | Anti-HLA class-IB antibodies mimic immunoreactivity and immunomodulatory functions of intravenous immunoglobulin (IVIG) useful as therapeutic IVIG mimetics and methods of their use |
WO2013106765A1 (en) | 2012-01-13 | 2013-07-18 | Genentech, Inc. | Biological markers for identifying patients for treatment with vegf antagonists |
WO2013107290A1 (en) | 2012-01-20 | 2013-07-25 | The Government of the Hong Kong Special Administrative Region of the People's Republic of China | A novel paramyxovirus and uses thereof |
US9139620B2 (en) | 2012-01-20 | 2015-09-22 | The Government of the Hong Kong Special Administrative Region of the People's Republic of China | Feline morbillivirus and uses thereof |
EP3653647A1 (en) | 2012-01-27 | 2020-05-20 | AbbVie Deutschland GmbH & Co KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
US9365643B2 (en) | 2012-01-27 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Antibodies that bind to repulsive guidance molecule A (RGMA) |
WO2013112922A1 (en) | 2012-01-27 | 2013-08-01 | AbbVie Deutschland GmbH & Co. KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
EP3369746A1 (en) | 2012-01-27 | 2018-09-05 | AbbVie Deutschland GmbH & Co KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
US10106602B2 (en) | 2012-01-27 | 2018-10-23 | AbbVie Deutschland GmbH & Co. KG | Isolated monoclonal anti-repulsive guidance molecule A antibodies and uses thereof |
US9102722B2 (en) | 2012-01-27 | 2015-08-11 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of diseases associated with neurite degeneration |
WO2013116287A1 (en) | 2012-01-31 | 2013-08-08 | Genentech, Inc. | Anti-ig-e m1' antibodies and methods using same |
US9663575B2 (en) | 2012-02-06 | 2017-05-30 | Inhibrx, Lp | CD47 antibodies and methods of use thereof |
US9045541B2 (en) | 2012-02-06 | 2015-06-02 | Inhibrx Llc | CD47 antibodies and methods of use thereof |
EP3578569A1 (en) | 2012-02-06 | 2019-12-11 | Inhibrx, Inc. | Cd47 antibodies and methods of use thereof |
WO2013117735A1 (en) | 2012-02-09 | 2013-08-15 | Medical Research Council | Conjugate comprising an agent and an antiviral ligand and its use in a method for delivering the agent intracellularly |
EP3575794A1 (en) | 2012-02-10 | 2019-12-04 | Seattle Genetics, Inc. | Detection and treatment of cd30+ cancers |
US9663568B2 (en) | 2012-02-15 | 2017-05-30 | Novo Nordisk A/S | Antibodies that bind peptidoglycan recognition protein 1 |
US10906975B2 (en) | 2012-02-15 | 2021-02-02 | Novo Nordisk A/S | Methods of treating autoimmune disease or chronic inflammation with antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US10189904B2 (en) | 2012-02-15 | 2019-01-29 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US9550830B2 (en) | 2012-02-15 | 2017-01-24 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US9000127B2 (en) | 2012-02-15 | 2015-04-07 | Novo Nordisk A/S | Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) |
US10150809B2 (en) | 2012-02-15 | 2018-12-11 | Bristol-Myers Squibb Company | Antibodies that bind peptidoglycan recognition protein 1 |
US10906965B2 (en) | 2012-02-15 | 2021-02-02 | Novo Nordisk A/S | Methods of treating autoimmune disease or chronic inflammation wtih antibodies that bind peptidoglycan recognition protein 1 |
WO2013126813A1 (en) | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
US10525130B2 (en) | 2012-03-26 | 2020-01-07 | Sanofi | Stable IGG4 based binding agent formulations |
WO2013148232A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
WO2013148315A1 (en) | 2012-03-27 | 2013-10-03 | Genentech, Inc. | Diagnosis and treatments relating to her3 inhibitors |
EP3725892A1 (en) | 2012-03-27 | 2020-10-21 | F. Hoffmann-La Roche AG | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
US10774155B2 (en) | 2012-03-28 | 2020-09-15 | Kymab Limited | Animal models and therapeutic molecules |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US11297811B2 (en) | 2012-03-28 | 2022-04-12 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
US9924705B2 (en) | 2012-03-28 | 2018-03-27 | Kymab Limited | Animal models and therapeutic molecules |
US9938357B2 (en) | 2012-03-28 | 2018-04-10 | Kymab Limited | Animal models and therapeutic molecules |
US9938358B2 (en) | 2012-03-28 | 2018-04-10 | Kymab Limited | Animal models and therapeutic molecules |
US9896516B2 (en) | 2012-03-28 | 2018-02-20 | Kymab Limited | Animal models and therapeutic molecules |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
WO2013144240A1 (en) | 2012-03-29 | 2013-10-03 | Friedrich Miescher Institute For Biomedical Research | Inhibition of interleukin- 8 and/or its receptor cxcrl in the treatment her2/her3 -overexpressing breast cancer |
WO2013148288A1 (en) | 2012-03-30 | 2013-10-03 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
WO2013155447A1 (en) | 2012-04-13 | 2013-10-17 | Children's Medical Center Corporation | Tiki inhibitors |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9346879B2 (en) | 2012-04-20 | 2016-05-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9957318B2 (en) | 2012-04-20 | 2018-05-01 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9359434B2 (en) | 2012-04-20 | 2016-06-07 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9683033B2 (en) | 2012-04-20 | 2017-06-20 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9193787B2 (en) | 2012-04-20 | 2015-11-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9708400B2 (en) | 2012-04-20 | 2017-07-18 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
EP3929208A1 (en) | 2012-04-27 | 2021-12-29 | Amgen Inc. | Human cd30 ligand antigen binding proteins |
EP3431492A1 (en) | 2012-04-27 | 2019-01-23 | Novo Nordisk A/S | Human cd30 ligand antigen binding proteins |
EP4230641A2 (en) | 2012-04-27 | 2023-08-23 | Amgen Inc. | Human cd30 ligand antigen binding proteins |
WO2013163377A1 (en) | 2012-04-27 | 2013-10-31 | Novo Nordisk A/S | Human cd30 ligand antigen binding proteins |
WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
EP3656399A1 (en) | 2012-05-03 | 2020-05-27 | Amgen, Inc | Stable formulations containing anti-pcsk9 antibodies |
WO2013165590A1 (en) | 2012-05-03 | 2013-11-07 | Fibrogen, Inc. | Methods for treating idiopathic pulmonary fibrosis |
WO2013166448A1 (en) | 2012-05-03 | 2013-11-07 | Amgen Inc. | Stable formulations containing anti-pcsk9 antibodies |
WO2013166290A1 (en) | 2012-05-04 | 2013-11-07 | Abbvie Biotherapeutics Inc. | P21 biomarker assay |
US9796780B2 (en) | 2012-05-14 | 2017-10-24 | Biogen Ma Inc. | LINGO-2 antagonists for treatment of conditions involving motor neurons |
WO2013172951A1 (en) | 2012-05-15 | 2013-11-21 | Morphotek, Inc. | Methods for treatment of gastric cancer |
US9289507B2 (en) | 2012-05-17 | 2016-03-22 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
US9173950B2 (en) | 2012-05-17 | 2015-11-03 | Extend Biosciences, Inc. | Vitamin D-ghrelin conjugates |
US9884124B2 (en) | 2012-05-17 | 2018-02-06 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
US10667501B2 (en) | 2012-05-17 | 2020-06-02 | Kymab Limited | Transgenic non-human vertebrate for the in vivo production of dual specificity immunoglobulins or hypermutated heavy chain only immunoglobulins |
EP3693395A1 (en) | 2012-05-18 | 2020-08-12 | Amgen Inc. | St2 antigen binding proteins |
WO2013177386A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Biotherapeutics Inc. | Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
EP3556776A1 (en) | 2012-05-31 | 2019-10-23 | F. Hoffmann-La Roche AG | Methods of treating cancer using pd-1 axis binding antagonists and vegf antagonists |
WO2013181452A1 (en) | 2012-05-31 | 2013-12-05 | Genentech, Inc. | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
US9617334B2 (en) | 2012-06-06 | 2017-04-11 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
US9951128B2 (en) | 2012-06-06 | 2018-04-24 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
US11666040B2 (en) | 2012-06-12 | 2023-06-06 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
US10238093B2 (en) | 2012-06-12 | 2019-03-26 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
US10542735B2 (en) | 2012-06-12 | 2020-01-28 | Regerneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
US11559050B2 (en) | 2012-06-12 | 2023-01-24 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
WO2013192550A2 (en) | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
US9822148B2 (en) | 2012-06-25 | 2017-11-21 | Hoya Corporation | EGFR-binding peptide |
WO2014001482A1 (en) | 2012-06-29 | 2014-01-03 | Novartis Forschungsstiftung, Zweigniererlassung, Friedrich Miescher Institute For Biomedical Research | Treating diseases by modulating a specific isoform of mkl1 |
WO2014006114A1 (en) | 2012-07-05 | 2014-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
US10656156B2 (en) | 2012-07-05 | 2020-05-19 | Mepur Ravindranath | Diagnostic and therapeutic potential of HLA-E monospecific monoclonal IgG antibodies directed against tumor cell surface and soluble HLA-E |
WO2014006115A1 (en) | 2012-07-06 | 2014-01-09 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction |
US9670276B2 (en) | 2012-07-12 | 2017-06-06 | Abbvie Inc. | IL-1 binding proteins |
US10696749B2 (en) | 2012-07-13 | 2020-06-30 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
US11795240B2 (en) | 2012-07-13 | 2023-10-24 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
US9765156B2 (en) | 2012-07-13 | 2017-09-19 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
EP3730512A1 (en) | 2012-07-13 | 2020-10-28 | The Trustees of the University of Pennsylvania | Enhancing activity of car t cells by co-introducing a bispecific antibody |
US9259488B2 (en) | 2012-08-17 | 2016-02-16 | The Regents Of The University Of Colorado, A Body Corporate | Anti-C3d antibody conjugates and methods of detecting complement activation |
US11191851B2 (en) | 2012-08-17 | 2021-12-07 | Musc Foundation For Research Development | Anti-C3d antibody conjugates and methods of detecting complement activation |
US9914956B2 (en) | 2012-08-18 | 2018-03-13 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
US10214765B2 (en) | 2012-08-18 | 2019-02-26 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
US9547009B2 (en) | 2012-08-21 | 2017-01-17 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
EP3712175A1 (en) | 2012-08-31 | 2020-09-23 | ImmunoGen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
WO2014036495A2 (en) | 2012-08-31 | 2014-03-06 | Immunogen Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
US9234033B2 (en) | 2012-09-02 | 2016-01-12 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9290568B2 (en) | 2012-09-02 | 2016-03-22 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2014039975A2 (en) | 2012-09-10 | 2014-03-13 | Neotope Biosciences Limited | Anti-mcam antibodies and associated methods of use |
EP3530287A1 (en) | 2012-09-10 | 2019-08-28 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
WO2014055370A1 (en) | 2012-10-01 | 2014-04-10 | Abbvie Biotherapeutics Inc. | Compostions and methods for producing glycoproteins |
US10329355B2 (en) | 2012-10-01 | 2019-06-25 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
US11718685B2 (en) | 2012-10-01 | 2023-08-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
US9365641B2 (en) | 2012-10-01 | 2016-06-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
US10844117B2 (en) | 2012-10-05 | 2020-11-24 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
WO2014063205A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Queensland | Use of endocytosis inhibitors and antibodies for cancer therapy |
US9944720B2 (en) | 2012-11-01 | 2018-04-17 | Abbvie Inc. | Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof |
US9163093B2 (en) | 2012-11-01 | 2015-10-20 | Abbvie Inc. | Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof |
US9045551B2 (en) | 2012-11-01 | 2015-06-02 | Abbvie Inc. | Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof |
WO2014085654A1 (en) | 2012-11-30 | 2014-06-05 | Abbvie Biotherapeutics Inc. | Anti-vegf antibodies and their uses |
US9815893B2 (en) | 2012-11-30 | 2017-11-14 | Abbvie Biotherapeutics Inc. | Anti-VEGF antibodies and their uses |
US9383357B2 (en) | 2012-12-07 | 2016-07-05 | Northwestern University | Biomarker for replicative senescence |
EP3597191A1 (en) | 2012-12-07 | 2020-01-22 | Sanofi | Compositions comprising anti-cd38 antibodies and lenalidomide for use in treating cancer |
US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
WO2014089416A1 (en) | 2012-12-07 | 2014-06-12 | Sanofi | Compositions comprising anti-cd38 antibodies and lenalidomide |
JP2016505257A (en) * | 2012-12-14 | 2016-02-25 | オーエムティー,インコーポレイティド | Polynucleotide encoding rodent antibody having human idiotype and animal containing the same |
US9968670B2 (en) | 2012-12-18 | 2018-05-15 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
US10583188B2 (en) | 2012-12-18 | 2020-03-10 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
US10137189B2 (en) | 2012-12-18 | 2018-11-27 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
EP4154907A1 (en) | 2012-12-18 | 2023-03-29 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
US9371366B2 (en) | 2012-12-18 | 2016-06-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
WO2014100483A1 (en) | 2012-12-19 | 2014-06-26 | Amplimmune, Inc. | Anti-human b7-h4 antibodies and their uses |
WO2014100823A1 (en) | 2012-12-21 | 2014-06-26 | Amplimmune, Inc. | Anti-h7cr antibodies |
WO2014114801A1 (en) | 2013-01-25 | 2014-07-31 | Amgen Inc. | Antibodies targeting cdh19 for melanoma |
WO2014114800A1 (en) | 2013-01-25 | 2014-07-31 | Amgen Research (Munich) Gmbh | Antibody constructs for cdh19 and cd3 |
EP3699194A1 (en) | 2013-01-25 | 2020-08-26 | Amgen Research (Munich) GmbH | Antibody constructs for cdh19 and cd3 |
US11498964B2 (en) | 2013-01-25 | 2022-11-15 | Amgen Research (Munich) Gmbh | Antibody constructs for CDH19 and CD3 |
US9834610B2 (en) | 2013-01-31 | 2017-12-05 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector T cells |
EP4137518A1 (en) | 2013-02-06 | 2023-02-22 | Inhibrx, Inc. | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
WO2014129895A1 (en) | 2013-02-19 | 2014-08-28 | Stichting Vu-Vumc | Means and method for increasing the sensitivity of cancers for radiotherapy |
US9930871B2 (en) | 2013-02-20 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
US10820581B2 (en) | 2013-02-20 | 2020-11-03 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
US9204624B2 (en) | 2013-02-20 | 2015-12-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modifed immunoglobulin heavy chain sequences |
US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
US11224208B2 (en) | 2013-02-22 | 2022-01-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US10154658B2 (en) | 2013-02-22 | 2018-12-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
US10314296B2 (en) | 2013-02-22 | 2019-06-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
WO2014130923A2 (en) | 2013-02-25 | 2014-08-28 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
US10421823B2 (en) | 2013-03-13 | 2019-09-24 | Amgen Inc. | Proteins specific for BAFF and B7RP1 and uses thereof |
US10010611B2 (en) | 2013-03-13 | 2018-07-03 | Genentech, Inc. | Antibody formulations |
EP3744345A1 (en) | 2013-03-13 | 2020-12-02 | F. Hoffmann-La Roche AG | Antibody formulations |
US10925966B2 (en) | 2013-03-13 | 2021-02-23 | Genentech, Inc. | Antibody formulations |
WO2014160490A1 (en) | 2013-03-13 | 2014-10-02 | Genetech, Inc. | Antibody formulations |
US10421824B2 (en) | 2013-03-13 | 2019-09-24 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
EP3769783A1 (en) | 2013-03-13 | 2021-01-27 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
US11492417B2 (en) | 2013-03-13 | 2022-11-08 | Amgen Inc. | Proteins specific for BAFF and B7RP1 and uses thereof |
WO2014159911A1 (en) | 2013-03-13 | 2014-10-02 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
US11596620B2 (en) | 2013-03-13 | 2023-03-07 | F. Hoffmann-La Roche Ag | Formulations with reduced oxidation |
US10653779B2 (en) | 2013-03-13 | 2020-05-19 | Genentech, Inc. | Formulations with reduced oxidation |
WO2014160495A1 (en) | 2013-03-13 | 2014-10-02 | Genentech, Inc. | Formulations with reduced oxidation |
WO2014160497A1 (en) | 2013-03-13 | 2014-10-02 | Genentech, Inc. | Formulations with reduced oxidation |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
EP3841876A1 (en) | 2013-03-14 | 2021-06-30 | Erasmus University Medical Center Rotterdam | Transgenic mouse for antibody production |
US9980470B2 (en) | 2013-03-14 | 2018-05-29 | Erasmus University Medical Center | Antibody production |
US9708399B2 (en) | 2013-03-14 | 2017-07-18 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9790478B2 (en) | 2013-03-14 | 2017-10-17 | Abbott Laboratories | HCV NS3 recombinant antigens and mutants thereof for improved antibody detection |
EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
US10444242B2 (en) | 2013-03-14 | 2019-10-15 | Abbott Laboratories | Detection methods employing HCV core lipid and DNA binding domain monoclonal antibodies |
WO2014153056A2 (en) | 2013-03-14 | 2014-09-25 | Parkash Gill | Cancer treatment using antibodies that bing cell surface grp78 |
US10197573B2 (en) | 2013-03-14 | 2019-02-05 | Abbott Laboratories | HCV core lipid binding domain monoclonal antibodies |
US10345311B2 (en) | 2013-03-14 | 2019-07-09 | Abbott Laboratories | Detection methods employing HCV core lipid and DNA binding domain monoclonal antibodies |
US10544207B2 (en) | 2013-03-14 | 2020-01-28 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
US9841427B2 (en) | 2013-03-14 | 2017-12-12 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
WO2014159764A1 (en) | 2013-03-14 | 2014-10-02 | Amgen Inc. | Chrdl-1 antigen binding proteins and methods of treatment |
WO2014141189A1 (en) | 2013-03-14 | 2014-09-18 | Erasmus University Medical Center | Transgenic non-human mammal for antibody production |
EP3916103A1 (en) | 2013-03-14 | 2021-12-01 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
US11428694B2 (en) | 2013-03-14 | 2022-08-30 | Abbott Laboratories | Detection methods employing HCV core lipid and DNA binding domain monoclonal antibodies |
EP3653642A1 (en) | 2013-03-15 | 2020-05-20 | Amgen Research (Munich) GmbH | Single chain binding molecules comprising n-terminal abp |
WO2014140368A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Antibody constructs for influenza m2 and cd3 |
WO2014145000A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Anti-cd25 antibodies and their uses |
US10829732B2 (en) | 2013-03-15 | 2020-11-10 | Genentech, Inc. | Cell culture compositions with antioxidants and methods for polypeptide production |
EP3683237A1 (en) | 2013-03-15 | 2020-07-22 | Amgen Inc. | Human pac1 antibodies |
US10017732B2 (en) | 2013-03-15 | 2018-07-10 | Genentech, Inc. | Cell culture compositions with antioxidants and methods for polypeptide production |
US9062108B2 (en) | 2013-03-15 | 2015-06-23 | Abbvie Inc. | Dual specific binding proteins directed against IL-1 and/or IL-17 |
US10308709B2 (en) | 2013-03-15 | 2019-06-04 | Abbott Laboratories | Anti-GP73 monoclonal antibodies and methods of obtaining the same |
WO2014144935A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Anti-cd25 antibodies and their uses |
US9469686B2 (en) | 2013-03-15 | 2016-10-18 | Abbott Laboratories | Anti-GP73 monoclonal antibodies and methods of obtaining the same |
EP3527586A1 (en) | 2013-03-15 | 2019-08-21 | Abbott Laboratories | Anti-gp73 monoclonal antibodies and methods of obtaining the same |
WO2014144960A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Fc variants |
EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
WO2014140358A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Single chain binding molecules comprising n-terminal abp |
WO2014144763A2 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan Kettering Cancer Center | High affinity anti-gd2 antibodies |
US11421023B2 (en) | 2013-03-15 | 2022-08-23 | Abbott Laboratories | Anti-GP73 monoclonal antibodies and methods of obtaining the same |
EP3124499A1 (en) | 2013-03-15 | 2017-02-01 | Abbott Laboratories | Anti-gp73 monoclonal antibodies and methods of obtaining the same |
EP3216804A2 (en) | 2013-03-15 | 2017-09-13 | AbbVie Biotechnology Ltd. | Anti-cd25 antibodies and their uses |
WO2014145254A2 (en) | 2013-03-15 | 2014-09-18 | Sutter West Bay Hospitals | Falz for use as a target for therapies to treat cancer |
US8987418B2 (en) | 2013-03-15 | 2015-03-24 | Abbvie Inc. | Dual specific binding proteins directed against IL-1β and/or IL-17 |
US10745483B2 (en) | 2013-03-15 | 2020-08-18 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides |
US9441035B2 (en) | 2013-03-15 | 2016-09-13 | Genentech, Inc. | Cell culture media and methods of antibody production |
WO2014145098A1 (en) | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Cell culture compositions with antioxidants and methods for polypeptide production |
US10526411B2 (en) | 2013-03-15 | 2020-01-07 | Amgen Inc. | Methods and compositions relating to anti-CCR7 antigen binding proteins |
WO2014144553A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Secreted frizzle-related protein 5 (sfrp5) binding proteins and methods of treatment |
WO2014144632A2 (en) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Human pac1 antibodies |
EP3712252A1 (en) | 2013-03-15 | 2020-09-23 | F. Hoffmann-La Roche AG | Cell culture compositions with antioxidants and methods for polypeptide production |
US10676710B2 (en) | 2013-03-15 | 2020-06-09 | Genentech, Inc. | Cell culture compositions with antioxidants and methods for polypeptide production |
WO2014144355A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Anti-gp73 monoclonal antibodies and methods of obtaining the same |
WO2014151834A2 (en) | 2013-03-15 | 2014-09-25 | Amgen Inc. | Methods and compositions relating to anti-ccr7 antigen binding proteins |
US10131873B2 (en) | 2013-03-15 | 2018-11-20 | Genentech, Inc. | Cell culture compositions with antioxidants and methods for polypeptide production |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US10226033B2 (en) | 2013-03-18 | 2019-03-12 | Kymab Limited | Animal models and therapeutic molecules |
US11297810B2 (en) | 2013-03-18 | 2022-04-12 | Kymab Limited | Animal models and therapeutic molecules |
WO2014165818A2 (en) | 2013-04-05 | 2014-10-09 | T Cell Therapeutics, Inc. | Compositions and methods for preventing and treating prostate cancer |
WO2014169076A1 (en) | 2013-04-09 | 2014-10-16 | Annexon,,Inc. | Methods of treatment for neuromyelitis optica |
US10005835B2 (en) | 2013-04-29 | 2018-06-26 | Sanofi | Anti-IL-4/anti-IL-13 bispecific antibody formulations |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US10730930B2 (en) | 2013-05-02 | 2020-08-04 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
US11820810B2 (en) | 2013-05-02 | 2023-11-21 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US10981981B2 (en) | 2013-05-06 | 2021-04-20 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
US11827698B2 (en) | 2013-05-06 | 2023-11-28 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
US10597443B2 (en) | 2013-05-06 | 2020-03-24 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
US9758576B2 (en) | 2013-05-06 | 2017-09-12 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
US9989540B2 (en) | 2013-05-10 | 2018-06-05 | The Regents Of The University Of California | Diagnostic and monitoring system for Huntington's disease |
WO2014190356A2 (en) | 2013-05-24 | 2014-11-27 | Amplimmune, Inc. | Anti-b7-h5 antibodies and their uses |
EP4349864A2 (en) | 2013-05-30 | 2024-04-10 | Kiniksa Pharmaceuticals, Ltd. | Oncostatin m receptor antigen binding proteins |
EP3456743A1 (en) | 2013-05-30 | 2019-03-20 | Kiniksa Pharmaceuticals, Ltd. | Oncostatin m receptor antigen binding proteins |
EP3971212A1 (en) | 2013-05-30 | 2022-03-23 | Kiniksa Pharmaceuticals, Ltd. | Oncostatin m receptor antigen binding proteins |
WO2014197866A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Modified antibodies and related compounds, compositions, and methods of use |
WO2014197849A2 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Anti-c10orf54 antibodies and uses thereof |
US10421818B2 (en) | 2013-06-06 | 2019-09-24 | Pierre Fabre Medicament | Anti-C10orf54 antibodies and uses thereof |
US10414823B2 (en) | 2013-06-06 | 2019-09-17 | Pierre Fabre Medicament | Anti-C10orf54 antibodies and uses thereof |
US10100123B2 (en) | 2013-06-06 | 2018-10-16 | Pierre Fabre Medicament | Anti-C10orf54 antibodies and uses thereof |
EP3632467A1 (en) | 2013-06-07 | 2020-04-08 | Duke University | Inhibitors of complement factor h |
US11897946B2 (en) | 2013-06-07 | 2024-02-13 | Duke University | Methods of inhibiting complement factor H (CFH) comprising administering an antibody that binds CFH |
US11136380B2 (en) | 2013-06-07 | 2021-10-05 | Duke University | Anti-complement factor H antibodies |
US10183988B2 (en) | 2013-06-07 | 2019-01-22 | Duke University | Anti-Complement factor H antibodies |
WO2014200349A1 (en) | 2013-06-13 | 2014-12-18 | Fast Forward Pharmaceutical B.V. | Cd40 signalling inhibitor and a further compound, wherein the further compound is a bile acid, a bile acid derivative, an tgr5-receptor agonist, an fxr agonist or a combination thereof, for the treatment of chronic inflammation, and the prevention of gastrointestinal cancer or fibrosis. |
US9499628B2 (en) | 2013-06-14 | 2016-11-22 | Children's Hospital Medical Center | Method of boosting the immune response in neonates |
US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
WO2014209384A1 (en) | 2013-06-28 | 2014-12-31 | Amgen Inc. | Methods for treating homozygous familial hypercholesterolema |
EP4252769A2 (en) | 2013-07-09 | 2023-10-04 | Annexon, Inc. | Anti-complement factor c1q antibodies and uses thereof |
WO2015006504A1 (en) | 2013-07-09 | 2015-01-15 | Annexon, Inc. | Anti-complement factor c1q antibodies and uses thereof |
EP3789036A1 (en) | 2013-07-16 | 2021-03-10 | F. Hoffmann-La Roche AG | Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors |
WO2015017146A2 (en) | 2013-07-18 | 2015-02-05 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
WO2015010100A2 (en) | 2013-07-18 | 2015-01-22 | Fabrus, Inc. | Humanized antibodies with ultralong complementarity determining regions |
WO2015019286A1 (en) | 2013-08-07 | 2015-02-12 | Friedrich Miescher Institute For Biomedical Research | New screening method for the treatment friedreich's ataxia |
US10457744B2 (en) | 2013-08-07 | 2019-10-29 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
EP3617234A1 (en) | 2013-08-07 | 2020-03-04 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
EP3705494A2 (en) | 2013-08-14 | 2020-09-09 | Sachdev Sidhu | Antibodies against frizzled proteins and methods of use thereof |
US10077304B2 (en) | 2013-08-14 | 2018-09-18 | The Governing Council Of The University Of Toronto | Antibodies against frizzled receptor |
US10689442B2 (en) | 2013-08-14 | 2020-06-23 | Sachdev Sidhu | Antibodies against Frizzled receptor |
EP3427751A1 (en) | 2013-08-30 | 2019-01-16 | Amgen, Inc | Gitr antigen binding proteins |
WO2015031808A2 (en) | 2013-08-30 | 2015-03-05 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
WO2015031782A1 (en) | 2013-08-30 | 2015-03-05 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
US9464139B2 (en) | 2013-08-30 | 2016-10-11 | Amgen Inc. | GITR antigen binding proteins and methods of use thereof |
WO2015035044A2 (en) | 2013-09-04 | 2015-03-12 | Abbvie Biotherapeutics Inc. | Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY |
US10111951B2 (en) | 2013-09-06 | 2018-10-30 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
US10918714B2 (en) | 2013-09-06 | 2021-02-16 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
US10875922B2 (en) | 2013-09-27 | 2020-12-29 | Genentech, Inc. | Anti-PDL1 antibody formulations |
WO2015048520A1 (en) | 2013-09-27 | 2015-04-02 | Genentech, Inc. | Anti-pdl1 antibody formulations |
EP3626742A1 (en) | 2013-09-27 | 2020-03-25 | F. Hoffmann-La Roche AG | Anti-pdl1 antibody formulations |
US11399522B2 (en) | 2013-10-01 | 2022-08-02 | Kymab Limited | Animal models and therapeutic molecules |
US10149462B2 (en) | 2013-10-01 | 2018-12-11 | Kymab Limited | Animal models and therapeutic molecules |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
WO2015054427A1 (en) | 2013-10-10 | 2015-04-16 | Beth Israel Deaconess Medical Center, Inc. | Tm4sf1 binding proteins and methods of using same |
US9499616B2 (en) | 2013-10-18 | 2016-11-22 | Abbvie Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9688752B2 (en) | 2013-10-18 | 2017-06-27 | Abbvie Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9315574B2 (en) | 2013-10-18 | 2016-04-19 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9200069B2 (en) | 2013-10-18 | 2015-12-01 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9200070B2 (en) | 2013-10-18 | 2015-12-01 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9522953B2 (en) | 2013-10-18 | 2016-12-20 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9266949B2 (en) | 2013-10-18 | 2016-02-23 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
EP3733868A2 (en) | 2013-10-28 | 2020-11-04 | DOTS Technology Corp. | Allergen detection |
EP3805266A1 (en) | 2013-10-31 | 2021-04-14 | Sanofi | Specific anti-cd38 antibodies for treating human cancers |
WO2015066450A1 (en) | 2013-10-31 | 2015-05-07 | Sanofi | Specific anti-cd38 antibodies for treating human cancers |
EP3556863A1 (en) | 2013-11-06 | 2019-10-23 | Astute Medical, Inc. | Assays for igfbp7 having improved performance in biological samples |
US9550826B2 (en) | 2013-11-15 | 2017-01-24 | Abbvie Inc. | Glycoengineered binding protein compositions |
US10106611B2 (en) | 2013-12-06 | 2018-10-23 | Dana-Farber Cancer Institute, Inc. | Antibodies that bind to MHC class I polypeptide-related sequence A |
WO2015088346A1 (en) | 2013-12-13 | 2015-06-18 | Rijksuniversiteit Groningen | Antibodies against staphylococcus aureus and uses thereof. |
US10611849B2 (en) | 2013-12-17 | 2020-04-07 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
EP3680254A1 (en) | 2013-12-17 | 2020-07-15 | F. Hoffmann-La Roche AG | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
WO2015095410A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody |
WO2015095418A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies |
WO2015095423A2 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
US9040052B1 (en) | 2013-12-17 | 2015-05-26 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
EP3527587A1 (en) | 2013-12-17 | 2019-08-21 | F. Hoffmann-La Roche AG | Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists |
EP3647324A1 (en) | 2013-12-17 | 2020-05-06 | F. Hoffmann-La Roche AG | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
US11434305B2 (en) | 2013-12-17 | 2022-09-06 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
US10618971B2 (en) | 2013-12-17 | 2020-04-14 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
WO2015095539A1 (en) | 2013-12-20 | 2015-06-25 | Genentech, Inc. | Dual specific antibodies |
EP3712174A1 (en) | 2013-12-24 | 2020-09-23 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
EP4043493A1 (en) | 2013-12-24 | 2022-08-17 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
WO2015097536A2 (en) | 2013-12-24 | 2015-07-02 | Janssen Pharmaceutical Nv | Anti-vista antibodies and fragments |
EP2893939A1 (en) | 2014-01-10 | 2015-07-15 | Netris Pharma | Anti-netrin-1 antibody |
WO2015104360A1 (en) | 2014-01-10 | 2015-07-16 | Netris Pharma | Novel anti-netrin-1 antibody |
WO2015109180A2 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US9982041B2 (en) | 2014-01-16 | 2018-05-29 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
WO2015120075A2 (en) | 2014-02-04 | 2015-08-13 | Genentech, Inc. | Mutant smoothened and methods of using the same |
US11773175B2 (en) | 2014-03-04 | 2023-10-03 | Kymab Limited | Antibodies, uses and methods |
EP3590539A1 (en) | 2014-03-04 | 2020-01-08 | Kymab Limited | Antibodies, uses & methods |
US11753479B2 (en) | 2014-03-04 | 2023-09-12 | Kymab Limited | Nucleic acids encoding anti-OX40L antibodies |
US10279021B2 (en) | 2014-03-14 | 2019-05-07 | Dana-Faber Cancer Institute, Inc. | Vaccine compositions and methods for restoring NKG2D pathway function against cancers |
US10881085B2 (en) | 2014-03-21 | 2021-01-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
US10787522B2 (en) | 2014-03-21 | 2020-09-29 | Regeneron Pharmaceuticals, Inc. | VL antigen binding proteins exhibiting distinct binding characteristics |
WO2015148736A1 (en) | 2014-03-25 | 2015-10-01 | Genentech, Inc. | Methods of preparing a poloxamer for use in cell culture medium |
US11034793B2 (en) | 2014-03-25 | 2021-06-15 | Genentech, Inc. | Methods of preparing a poloxamer for use in cell culture medium |
EP3778702A1 (en) | 2014-03-25 | 2021-02-17 | F. Hoffmann-La Roche AG | Methods of preparing a poloxamer for use in cell culture medium |
US11912823B2 (en) | 2014-03-25 | 2024-02-27 | Genentech, Inc. | Methods of preparing a poloxamer for use in cell culture medium |
US10119972B2 (en) | 2014-03-27 | 2018-11-06 | Academia Sinica | Reactive labelling compounds and uses thereof |
US9759726B2 (en) | 2014-03-27 | 2017-09-12 | Academia Sinica | Reactive labelling compounds and uses thereof |
US9975957B2 (en) | 2014-03-31 | 2018-05-22 | Genentech, Inc. | Anti-OX40 antibodies and methods of use |
US10730951B2 (en) | 2014-03-31 | 2020-08-04 | Genentech, Inc. | Anti-OX40 antibodies and methods of use |
US10358500B2 (en) | 2014-04-04 | 2019-07-23 | Bionomics Inc. | Humanized antibodies that bind LGR5 |
EP3804745A1 (en) | 2014-04-25 | 2021-04-14 | The Brigham and Women's Hospital, Inc. | Methods to manipulate alpha-fetoprotein (afp) |
EP3888690A2 (en) | 2014-05-16 | 2021-10-06 | MedImmune, LLC | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
WO2015175874A2 (en) | 2014-05-16 | 2015-11-19 | Medimmune, Llc | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
WO2015179627A1 (en) | 2014-05-21 | 2015-11-26 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer with anti bip or anti mica antibodies |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
US11884739B2 (en) | 2014-05-27 | 2024-01-30 | Academia Sinica | Anti-CD20 glycoantibodies and uses thereof |
US10023892B2 (en) | 2014-05-27 | 2018-07-17 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
EP4116329A1 (en) | 2014-05-27 | 2023-01-11 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
US11319567B2 (en) | 2014-05-27 | 2022-05-03 | Academia Sinica | Fucosidase from bacteroides and methods using the same |
US10618973B2 (en) | 2014-05-27 | 2020-04-14 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
US10005847B2 (en) | 2014-05-27 | 2018-06-26 | Academia Sinica | Anti-HER2 glycoantibodies and uses thereof |
WO2015184099A1 (en) | 2014-05-28 | 2015-12-03 | 4-Antibody Ag | Anti-gitr antibodies and methods of use thereof |
EP3498295A1 (en) | 2014-05-28 | 2019-06-19 | Agenus Inc. | Anti-gitr antibodies and methods of use thereof |
US11332523B2 (en) | 2014-05-28 | 2022-05-17 | Academia Sinica | Anti-TNF-alpha glycoantibodies and uses thereof |
WO2015189816A1 (en) | 2014-06-13 | 2015-12-17 | Friedrich Miescher Institute For Biomedical Research | New treatment against influenza virus |
WO2015195917A1 (en) | 2014-06-18 | 2015-12-23 | Mersana Therapeutics, Inc. | Monoclonal antibodies against her2 epitope and methods of use thereof |
EP4285917A2 (en) | 2014-06-18 | 2023-12-06 | Mersana Therapeutics, Inc. | Monoclonal antibodies against her2 epitope and methods of use thereof |
WO2015198202A1 (en) | 2014-06-23 | 2015-12-30 | Friedrich Miescher Institute For Biomedical Research | Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small rnas |
WO2016001830A1 (en) | 2014-07-01 | 2016-01-07 | Friedrich Miescher Institute For Biomedical Research | Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma |
EP3777535A1 (en) | 2014-07-09 | 2021-02-17 | F. Hoffmann-La Roche AG | Ph adjustment to improve thaw recovery of cell banks |
WO2016007752A1 (en) | 2014-07-09 | 2016-01-14 | Genentech, Inc. | Ph adjustment to improve thaw recovery of cell banks |
US10602739B2 (en) | 2014-07-09 | 2020-03-31 | Genentech, Inc. | PH adjustment to improve thaw recovery of cell banks |
WO2016011052A1 (en) | 2014-07-14 | 2016-01-21 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
US9045548B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
US9045545B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision medicine by targeting PD-L1 variants for treatment of cancer |
US9068012B1 (en) | 2014-07-15 | 2015-06-30 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
US10618955B2 (en) | 2014-07-15 | 2020-04-14 | Kymab Limited | Methods for treating neurodegenerative disease using anti-PD-1 antibodies |
US11555066B2 (en) | 2014-07-15 | 2023-01-17 | Kymab Limited | Precision medicine for cholesterol treatment |
US9067998B1 (en) | 2014-07-15 | 2015-06-30 | Kymab Limited | Targeting PD-1 variants for treatment of cancer |
US10946093B2 (en) | 2014-07-15 | 2021-03-16 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
US10711059B2 (en) | 2014-07-15 | 2020-07-14 | Kymab Limited | Methods for treating neurodegenerative diseases using anti-PD-L1 antibodies |
EP3563870A1 (en) | 2014-07-15 | 2019-11-06 | F. Hoffmann-La Roche AG | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
US9051378B1 (en) | 2014-07-15 | 2015-06-09 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
WO2016011160A1 (en) | 2014-07-15 | 2016-01-21 | Genentech, Inc. | Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors |
US11072654B2 (en) | 2014-07-17 | 2021-07-27 | Novo Nordisk A/S | Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity |
US11661462B2 (en) | 2014-07-31 | 2023-05-30 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody contructs |
US9765157B2 (en) | 2014-07-31 | 2017-09-19 | Amgen Research (Munich) Gmbh | Antibody constructs for CDH19 and CD3 |
WO2016016412A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Antibody constructs for cdh19 and cd3 |
WO2016016415A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Bispecific single chain antibody construct with enhanced tissue distribution |
WO2016016859A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody constructs |
EP4066859A1 (en) | 2014-08-08 | 2022-10-05 | Alector LLC | Anti-trem2 antibodies and methods of use thereof |
US11084875B2 (en) | 2014-08-08 | 2021-08-10 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
WO2016029079A2 (en) | 2014-08-21 | 2016-02-25 | Walter Reed Army Institute Of Research Department Of The Army | Monoclonal antibodies for treatment of microbial infections |
EP3311846A1 (en) | 2014-09-02 | 2018-04-25 | ImmunoGen, Inc. | Methods for formulating antibody drug conjugate compositions |
US10603388B2 (en) | 2014-09-02 | 2020-03-31 | Immunogen, Inc. | Methods for formulating antibody drug conjugate compositions |
US9879042B2 (en) | 2014-09-08 | 2018-01-30 | Academia Sinica | Human iNKT cell activation using glycolipids |
US10533034B2 (en) | 2014-09-08 | 2020-01-14 | Academia Sinica | Human iNKT cell activation using glycolipids |
WO2016040767A2 (en) | 2014-09-12 | 2016-03-17 | Amgen Inc. | Chrdl-1 epitopes and antibodies |
US11370833B2 (en) | 2014-09-15 | 2022-06-28 | Genentech, Inc. | Antibody formulations |
WO2016044224A1 (en) | 2014-09-15 | 2016-03-24 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
US10080790B2 (en) | 2014-09-19 | 2018-09-25 | The Regents Of The University Of Michigan | Staphylococcus aureus materials and methods |
US10596245B2 (en) | 2014-09-19 | 2020-03-24 | The Regents Of The University Of Michigan | Staphylococcus aureus materials and methods |
WO2016046768A1 (en) | 2014-09-24 | 2016-03-31 | Friedrich Miescher Institute For Biomedical Research | Lats and breast cancer |
US10202616B2 (en) | 2014-10-15 | 2019-02-12 | Amgen Inc. | Promoter and regulatory elements for improved expression of heterologous genes in host cells |
WO2016061240A1 (en) | 2014-10-15 | 2016-04-21 | Amgen Inc. | Promoter and regulatory elements for improved expression of heterologous genes in host cells |
EP3722433A1 (en) | 2014-10-15 | 2020-10-14 | Amgen Inc. | Promoter and regulatory elements for improved expression of heterologous genes in host cells |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
US10702574B2 (en) | 2014-10-22 | 2020-07-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
US10420819B2 (en) | 2014-10-22 | 2019-09-24 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
US10406202B2 (en) | 2014-10-22 | 2019-09-10 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
US11116816B2 (en) | 2014-10-22 | 2021-09-14 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US11208661B2 (en) | 2014-10-31 | 2021-12-28 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified T cells and uses thereof |
EP4219725A2 (en) | 2014-10-31 | 2023-08-02 | The Trustees of the University of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
US11203758B2 (en) | 2014-10-31 | 2021-12-21 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified T cells and uses thereof |
WO2016069283A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in cart cells and uses thereof |
US10308713B2 (en) | 2014-10-31 | 2019-06-04 | Abbvie Biotherapeutics Inc. | Anti-CS1 antibodies and antibody drug conjugates |
WO2016070089A2 (en) | 2014-10-31 | 2016-05-06 | Abbvie Biotherapeutics Inc. | Anti-cs1 antibodies and antibody drug conjugates |
US11471487B2 (en) | 2014-10-31 | 2022-10-18 | The Trustees Of The University Of Pennsylvania | Compositions and methods of stimulating and expanding T cells |
US10011657B2 (en) | 2014-10-31 | 2018-07-03 | Abbvie Biotherapeutics Inc. | Anti-CS1 antibodies and antibody drug conjugates |
WO2016073791A1 (en) | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
EP3753948A1 (en) | 2014-11-05 | 2020-12-23 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
WO2016073794A1 (en) | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
US11091530B2 (en) | 2014-11-05 | 2021-08-17 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
US11299539B2 (en) | 2014-11-05 | 2022-04-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
EP4295911A2 (en) | 2014-11-05 | 2023-12-27 | Annexon, Inc. | Humanized anti-complement factor c1q antibodies and uses thereof |
US10066002B2 (en) | 2014-11-05 | 2018-09-04 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
US10112994B2 (en) | 2014-11-05 | 2018-10-30 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
WO2016073282A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
WO2016073157A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Anti-ang2 antibodies and methods of use thereof |
US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
WO2016077526A1 (en) | 2014-11-12 | 2016-05-19 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
EP4183806A2 (en) | 2014-11-12 | 2023-05-24 | Seagen Inc. | Glycan-interacting compounds and methods of use |
WO2016081384A1 (en) | 2014-11-17 | 2016-05-26 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
US10864268B2 (en) | 2014-11-18 | 2020-12-15 | Janssen Pharmaceutica Nv | CD47 antibodies, methods, and uses |
WO2016081423A1 (en) | 2014-11-18 | 2016-05-26 | Janssen Pharmaceutica Nv | Cd47 antibodies, methods, and uses |
US11270782B2 (en) | 2014-11-19 | 2022-03-08 | Koninklijke Philips N.V. | Diagnostic method employing HNL |
WO2016081808A1 (en) | 2014-11-20 | 2016-05-26 | The Regents Of The University Of California | Compositions and methods related to hematologic recovery |
WO2016090300A1 (en) | 2014-12-05 | 2016-06-09 | Genentech, Inc. | Methods and compositions for treating cancer using pd-1 axis antagonists and hpk1 antagonists |
US10766959B2 (en) | 2014-12-11 | 2020-09-08 | Pierre Fabre Medicament | Anti-C10ORF54 antibodies and uses thereof |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
US11873339B2 (en) | 2014-12-11 | 2024-01-16 | Pierre Fabre Medicament | Anti-C10orf54 antibodies and uses thereof |
US10703813B2 (en) | 2014-12-19 | 2020-07-07 | Universite De Nantes | Anti IL-34 antibodies |
WO2016106221A1 (en) | 2014-12-22 | 2016-06-30 | The Rockefeller University | Anti-mertk agonistic antibodies and uses thereof |
EP3789039A1 (en) | 2014-12-22 | 2021-03-10 | The Rockefeller University | Anti-mertk agonistic antibodies and uses thereof |
US10435467B2 (en) | 2015-01-08 | 2019-10-08 | Biogen Ma Inc. | LINGO-1 antagonists and uses for treatment of demyelinating disorders |
WO2016115345A1 (en) | 2015-01-14 | 2016-07-21 | The Brigham And Women's Hospital, | Treatment of cancer with anti-lap monoclonal antibodies |
WO2016114819A1 (en) | 2015-01-16 | 2016-07-21 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
WO2016118961A1 (en) | 2015-01-24 | 2016-07-28 | Academia Sinica | Cancer markers and methods of use thereof |
US10342858B2 (en) | 2015-01-24 | 2019-07-09 | Academia Sinica | Glycan conjugates and methods of use thereof |
US11236391B2 (en) | 2015-01-28 | 2022-02-01 | Genentech, Inc. | Gene expression markers and treatment of multiple sclerosis |
WO2016123329A2 (en) | 2015-01-28 | 2016-08-04 | Genentech, Inc. | Gene expression markers and treatment of multiple sclerosis |
WO2016123593A1 (en) | 2015-01-30 | 2016-08-04 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
EP4223873A2 (en) | 2015-01-31 | 2023-08-09 | The Trustees of the University of Pennsylvania | Compositions and methods for t cell delivery of therapeutic molecules |
US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
WO2016126972A1 (en) | 2015-02-04 | 2016-08-11 | Genentech, Inc. | Mutant smoothened and methods of using the same |
US11858993B2 (en) | 2015-02-09 | 2024-01-02 | Memorial Sloan Kettering Cancer Center | Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof |
WO2016130539A2 (en) | 2015-02-09 | 2016-08-18 | Memorial Sloan Kettering Cancer Center | Multi-specific antibodies with affinity for human a33 antigen and dota metal complex and uses thereof |
US10988534B2 (en) | 2015-02-09 | 2021-04-27 | Memorial Sloan Kettering Cancer Center | Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof |
WO2016137985A1 (en) | 2015-02-26 | 2016-09-01 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
US10800846B2 (en) | 2015-02-26 | 2020-10-13 | Merck Patent Gmbh | PD-1/PD-L1 inhibitors for the treatment of cancer |
US10711067B2 (en) | 2015-03-03 | 2020-07-14 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
EP4137157A1 (en) | 2015-03-03 | 2023-02-22 | Kymab Limited | Antibodies, uses and methods |
WO2016139482A1 (en) | 2015-03-03 | 2016-09-09 | Kymab Limited | Antibodies, uses & methods |
WO2016141111A1 (en) | 2015-03-03 | 2016-09-09 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
US11155601B2 (en) | 2015-03-06 | 2021-10-26 | CSL Behring Lengnau AG | Modified von Willebrand factor having improved half-life |
WO2016149368A1 (en) | 2015-03-17 | 2016-09-22 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
EP4190817A1 (en) | 2015-03-17 | 2023-06-07 | Memorial Sloan Kettering Cancer Center | Anti-muc16 antibodies and uses thereof |
US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
WO2016151558A1 (en) | 2015-03-25 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of factor d of the alternative complement pathway |
WO2016151557A1 (en) | 2015-03-25 | 2016-09-29 | Alexion Pharmaceuticals, Inc. | A method for measuring the protease activity of c5 convertase of the alternative complement pathway |
US10167334B2 (en) | 2015-04-03 | 2019-01-01 | Xoma Technology Ltd. | Treatment of cancer using anti-TGF-BETA and PD-1 antibodies |
US11685775B2 (en) | 2015-04-03 | 2023-06-27 | Xoma Technology Ltd. | Method of increasing the ratio of effector T cells to regulatory T cells in a tumor by administering to a subject a TGF-beta inhibitor and a PD-1 antibody |
EP3770171A1 (en) | 2015-04-03 | 2021-01-27 | XOMA Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
WO2016161410A2 (en) | 2015-04-03 | 2016-10-06 | Xoma Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
WO2016161446A1 (en) * | 2015-04-03 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
US10683347B2 (en) | 2015-04-03 | 2020-06-16 | Xoma Technology Ltd. | Treatment of cancer using anti-TGF-β and anti-PD-1 antibodies |
US11259510B2 (en) | 2015-04-06 | 2022-03-01 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
US10087255B2 (en) | 2015-04-07 | 2018-10-02 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
US11186645B2 (en) | 2015-04-07 | 2021-11-30 | Alector Llc | Isolated nucleic acids encoding anti-sortilin antibodies |
US11339223B2 (en) | 2015-04-07 | 2022-05-24 | Alector Llc | Methods of use of anti-Sortilin antibodies for treating a disease, disorder, or injury |
US11208488B2 (en) | 2015-04-07 | 2021-12-28 | Alector Llc | Methods of increasing progranulin levels using anti-Sortilin antibodies |
US10849992B1 (en) | 2015-04-07 | 2020-12-01 | Alector Llc | Methods of screening for sortilin binding antagonists |
EP3991748A2 (en) | 2015-04-07 | 2022-05-04 | Alector LLC | Anti-sortilin antibodies and methods of use thereof |
US10428150B2 (en) | 2015-04-07 | 2019-10-01 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
US10308718B2 (en) | 2015-04-07 | 2019-06-04 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
WO2016166360A1 (en) | 2015-04-17 | 2016-10-20 | Bayer Pharma Aktiengesellschaft | Bispecific antibody constructs for cdh3 and cd3 |
EP4276116A2 (en) | 2015-04-17 | 2023-11-15 | Amgen Research (Munich) GmbH | Bispecific antibody constructs for cdh3 and cd3 |
US11926666B2 (en) | 2015-04-17 | 2024-03-12 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs for CDH3 and CD3 |
US11028171B2 (en) | 2015-04-17 | 2021-06-08 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs for CDH3 and CD3 |
EP3653225A1 (en) | 2015-04-24 | 2020-05-20 | Amgen, Inc | Methods for treating or preventing migraine headache using antibodies directed at the cgrp receptor |
WO2016171742A1 (en) | 2015-04-24 | 2016-10-27 | Amgen Inc. | Methods for treating or preventing migraine headache |
US10857237B2 (en) | 2015-05-05 | 2020-12-08 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and MRI and/or X-ray contrast agents |
WO2016179517A1 (en) | 2015-05-07 | 2016-11-10 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
EP3936524A2 (en) | 2015-05-11 | 2022-01-12 | F. Hoffmann-La Roche AG | Compositions and methods of treating lupus nephritis |
EP3783029A1 (en) | 2015-05-12 | 2021-02-24 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer |
EP4292664A2 (en) | 2015-05-15 | 2023-12-20 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
EP3447075A2 (en) | 2015-05-15 | 2019-02-27 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
EP3718569A1 (en) | 2015-05-22 | 2020-10-07 | Translational Drug Development, LLC | Benzamide and active compound compositions and methods of use |
EP4209228A1 (en) | 2015-05-22 | 2023-07-12 | Translational Drug Development, LLC | Benzamide and active compound compositions and methods of use |
WO2016191397A1 (en) | 2015-05-22 | 2016-12-01 | Td2 Inc. | Benzamide and active compound compositions and methods of use |
EP3736290A1 (en) | 2015-05-29 | 2020-11-11 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
EP3708681A1 (en) | 2015-05-29 | 2020-09-16 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer |
EP4047022A1 (en) | 2015-05-29 | 2022-08-24 | AbbVie Inc. | Anti-cd40 antibodies and uses thereof |
EP3626744A1 (en) | 2015-05-29 | 2020-03-25 | AbbVie Inc. | Anti-cd40 antibodies and uses thereof |
WO2016196237A1 (en) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
WO2016196298A1 (en) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Therapeutic and diagnolstic methods for cancer |
WO2016191811A1 (en) | 2015-06-03 | 2016-12-08 | The University Of Queensland | Mobilizing agents and uses therefor |
US11136390B2 (en) | 2015-06-12 | 2021-10-05 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
WO2016201388A2 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
WO2016201389A2 (en) | 2015-06-12 | 2016-12-15 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
US11174313B2 (en) | 2015-06-12 | 2021-11-16 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
US9840554B2 (en) | 2015-06-15 | 2017-12-12 | Abbvie Inc. | Antibodies against platelet-derived growth factor (PDGF) |
US10869924B2 (en) | 2015-06-16 | 2020-12-22 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
WO2016205320A1 (en) | 2015-06-17 | 2016-12-22 | Genentech, Inc. | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes |
EP3722314A1 (en) | 2015-06-24 | 2020-10-14 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
WO2016207717A1 (en) | 2015-06-24 | 2016-12-29 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments |
WO2017004091A1 (en) | 2015-06-29 | 2017-01-05 | Genentech, Inc. | Type ii anti-cd20 antibody for use in organ transplantation |
US10519241B2 (en) | 2015-07-31 | 2019-12-31 | Amgen Research (Munich) Gmbh | Antibody constructs for EGFRVIII and CD3 |
WO2017021356A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs binding mesothelin and cd3 |
US11447567B2 (en) | 2015-07-31 | 2022-09-20 | Amgen Research (Munich) Gmbh | Antibody constructs for FLT3 and CD3 |
WO2017021354A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Antibody constructs for cd70 and cd3 |
US10294300B2 (en) | 2015-07-31 | 2019-05-21 | Amgen Research (Munich) Gmbh | Antibody constructs for DLL3 and CD3 |
US11155629B2 (en) | 2015-07-31 | 2021-10-26 | Amgen Research (Munich) Gmbh | Method for treating glioblastoma or glioma with antibody constructs for EGFRVIII and CD3 |
EP3912999A1 (en) | 2015-07-31 | 2021-11-24 | Amgen Research (Munich) GmbH | Bispecific antibody constructs binding egfrviii and cd3 |
EP4219562A2 (en) | 2015-07-31 | 2023-08-02 | Amgen Research (Munich) GmbH | Antibody constructs for flt3 and cd3 |
US10851170B2 (en) | 2015-07-31 | 2020-12-01 | Amgen Research (Munich) Gmbh | Antibody constructs for CD70 and CD3 |
WO2017021349A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs binding dll3 and cd3 |
US11884720B2 (en) | 2015-07-31 | 2024-01-30 | Amgen Research (Munich) Gmbh | Antibody constructs for MSLN and CD3 |
US10683351B2 (en) | 2015-07-31 | 2020-06-16 | Amgen Research (Munich) Gmbh | Antibody constructs for DLL3 and CD3 |
WO2017021370A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Bispecific antibody constructs binding egfrviii and cd3 |
US11591396B2 (en) | 2015-07-31 | 2023-02-28 | Amgen Research (Munich) Gmbh | Antibody constructs for DLL3 and CD3 |
EP4327885A2 (en) | 2015-07-31 | 2024-02-28 | Amgen Research (Munich) GmbH | Antibody constructs for msln and cd3 |
EP3865514A1 (en) | 2015-07-31 | 2021-08-18 | Amgen Research (Munich) GmbH | Bispecific antibody constructs binding dll3 and cd3 |
WO2017021362A1 (en) | 2015-07-31 | 2017-02-09 | Amgen Research (Munich) Gmbh | Antibody constructs for flt3 and cd3 |
US10927342B2 (en) | 2015-08-04 | 2021-02-23 | Regeneran Pharmaceuticals, Inc. | Taurine supplemented cell culture medium and methods of use |
US11312936B2 (en) | 2015-08-04 | 2022-04-26 | Regeneron Pharmaceuticals, Inc. | Taurine supplemented cell culture medium and methods of use |
US10253101B2 (en) | 2015-08-06 | 2019-04-09 | Xoma (Us) Llc | Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia |
US11186647B2 (en) | 2015-08-11 | 2021-11-30 | Legend Biotech Usa Inc. | Chimeric antigen receptors targeting BCMA and methods of use thereof |
EP3896091A1 (en) | 2015-08-11 | 2021-10-20 | Legend Biotech Ireland Limited | Chimeric antigen receptors targeting bcma and methods of use thereof |
EP4063397A1 (en) | 2015-08-11 | 2022-09-28 | Legend Biotech Ireland Limited | Chimeric antigen receptors based on single-domain antibodies and methods of use thereof |
US11535677B2 (en) | 2015-08-11 | 2022-12-27 | Legend Biotech Usa Inc. | Chimeric antigen receptors targeting BCMA and methods of use thereof |
US10934363B2 (en) | 2015-08-11 | 2021-03-02 | Legend Biotech Usa Inc. | Chimeric antigen receptors based on single domain antibodies and methods of use thereof |
EP4282878A2 (en) | 2015-08-11 | 2023-11-29 | Legend Biotech Ireland Limited | Chimeric antigen receptors targeting bcma and methods of use thereof |
WO2017031353A1 (en) | 2015-08-19 | 2017-02-23 | Rutgers, The State University Of New Jersey | Novel methods of generating antibodies |
US11391733B2 (en) | 2015-08-20 | 2022-07-19 | Roche Diagnostics Operations, Inc. | Particle-based immunoassay using a pegylated analyte-specific binding agent |
WO2017040301A1 (en) | 2015-08-28 | 2017-03-09 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
US10590198B2 (en) | 2015-08-28 | 2020-03-17 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
US11390680B2 (en) | 2015-08-28 | 2022-07-19 | Alector Llc | Anti-Siglec-7 antibodies and methods of use thereof |
WO2017040790A1 (en) | 2015-09-01 | 2017-03-09 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
US10935544B2 (en) | 2015-09-04 | 2021-03-02 | Obi Pharma, Inc. | Glycan arrays and method of use |
WO2017049004A1 (en) | 2015-09-15 | 2017-03-23 | Amgen Inc. | Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof |
WO2017058780A1 (en) | 2015-09-30 | 2017-04-06 | Merck Patent Gmbh | Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer |
WO2017062672A2 (en) | 2015-10-06 | 2017-04-13 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
WO2017072669A1 (en) | 2015-10-28 | 2017-05-04 | Friedrich Miescher Institute For Biomedical Research | Tenascin-w and biliary tract cancers |
WO2017075432A2 (en) | 2015-10-29 | 2017-05-04 | Alector Llc | Anti-siglec-9 antibodies and methods of use thereof |
US11667710B2 (en) | 2015-10-29 | 2023-06-06 | Alector Llc | Anti-Siglec-9 antibodies and methods of use thereof |
US10800844B2 (en) | 2015-10-29 | 2020-10-13 | Alector Llc | Anti-Siglec-9 antibodies and methods of use thereof |
WO2017076864A1 (en) | 2015-11-02 | 2017-05-11 | Netris Pharma | Combination therapy of ntn1 neutralizing agent with drugs inhibiting epigenetic control |
EP3909984A1 (en) | 2015-11-03 | 2021-11-17 | Merck Patent GmbH | Affinity matured c-met antibodies |
WO2017076492A1 (en) | 2015-11-03 | 2017-05-11 | Merck Patent Gmbh | Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof |
US11235063B2 (en) | 2015-11-03 | 2022-02-01 | Merck Patent Gmbh | Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof |
WO2017083582A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
US11028181B2 (en) | 2015-11-12 | 2021-06-08 | Seagen Inc. | Glycan-interacting compounds and methods of use |
EP4335851A2 (en) | 2015-11-25 | 2024-03-13 | ImmunoGen, Inc. | Pharmaceutical formulations and methods of use thereof |
WO2017091745A1 (en) | 2015-11-25 | 2017-06-01 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
US10188660B2 (en) | 2015-11-30 | 2019-01-29 | Abbvie Inc. | Anti-huLRRC15 antibody drug conjugates and methods for their use |
US10195209B2 (en) | 2015-11-30 | 2019-02-05 | Abbvie Inc. | Anti-huLRRC15 antibody drug conjugates and methods for their use |
US11045480B2 (en) | 2015-11-30 | 2021-06-29 | Abbvie Inc. | Anti-huLRRC15 antibody drug conjugates and methods for their use |
WO2017095808A1 (en) | 2015-11-30 | 2017-06-08 | Abbvie Inc. | ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
WO2017095805A1 (en) | 2015-11-30 | 2017-06-08 | Abbvie Inc. | ANTI-huLRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
EP3909983A1 (en) | 2015-12-02 | 2021-11-17 | STCube & Co. Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
US11253590B2 (en) | 2015-12-02 | 2022-02-22 | Stsciences, Inc. | Antibodies specific to glycosylated BTLA (B- and T- lymphocyte attenuator) |
WO2017106578A1 (en) | 2015-12-15 | 2017-06-22 | Amgen Inc. | Pacap antibodies and uses thereof |
WO2017109180A1 (en) | 2015-12-23 | 2017-06-29 | Julius-Maximilians-Universität Würzburg | Glycoprotein v inhibitors for use as coagulants |
US10294303B2 (en) | 2015-12-23 | 2019-05-21 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists |
US11046774B2 (en) | 2015-12-23 | 2021-06-29 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists |
EP3184544A1 (en) | 2015-12-23 | 2017-06-28 | Julius-Maximilians-Universität Würzburg | Glycoprotein v inhibitors for use as coagulants |
US10525137B2 (en) | 2015-12-30 | 2020-01-07 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
US10933141B2 (en) | 2015-12-30 | 2021-03-02 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
WO2017117304A1 (en) | 2015-12-30 | 2017-07-06 | Genentech, Inc. | Use of tryptophan derivatives for protein formulations |
WO2017117311A1 (en) | 2015-12-30 | 2017-07-06 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
EP3848709A1 (en) | 2015-12-31 | 2021-07-14 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating esophageal cancer |
US11085924B2 (en) | 2015-12-31 | 2021-08-10 | Syncerus S.À. R.L. | Compositions and methods for assessing the risk of cancer occurrence |
US11789021B2 (en) | 2015-12-31 | 2023-10-17 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating esophageal cancer |
EP3954998A1 (en) | 2015-12-31 | 2022-02-16 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating gastric cancer |
EP3954999A1 (en) | 2015-12-31 | 2022-02-16 | Progastrine et Cancers S.à r.l. | Compositions and methods for detecting and treating ovarian cancer |
US11760808B2 (en) | 2015-12-31 | 2023-09-19 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating ovarian cancer |
EP3862365A1 (en) | 2016-01-08 | 2021-08-11 | F. Hoffmann-La Roche AG | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies |
US11103589B2 (en) | 2016-01-08 | 2021-08-31 | Apg Therapeutics, Inc. | Polyethylenimine (PEI)-polypeptide conjugates and methods of use thereof |
US10301391B2 (en) | 2016-02-03 | 2019-05-28 | Amgen Research (Munich) Gmbh | BCMA and CD3 bispecific T cell engaging antibody constructs |
US11434302B2 (en) | 2016-02-03 | 2022-09-06 | Amgen Research (Munich) Gmbh | Bispecific T cell engaging antibody constructs |
US11352433B2 (en) | 2016-02-03 | 2022-06-07 | Amgen Research (Munich) Gmbh | BCMA and CD3 bispecific T cell engaging antibody constructs |
EP4039709A1 (en) | 2016-02-03 | 2022-08-10 | Amgen Research (Munich) GmbH | Bcma and cd3 bispecific t cell engaging antibody constructs |
US10781264B2 (en) | 2016-02-03 | 2020-09-22 | Amgen Research (Munich) Gmbh | PSMA and CD3 bispecific T cell engaging antibody constructs |
EP4206228A1 (en) | 2016-02-03 | 2023-07-05 | Amgen Research (Munich) GmbH | Psma and cd3 bispecific t cell engaging constructs |
WO2017136558A1 (en) | 2016-02-04 | 2017-08-10 | Curis, Inc. | Mutant smoothened and methods of using the same |
WO2017137830A1 (en) | 2016-02-12 | 2017-08-17 | Janssen Pharmaceutica Nv | Anti-vista (b7h5) antibodies |
WO2017151502A1 (en) | 2016-02-29 | 2017-09-08 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
EP4155415A1 (en) | 2016-02-29 | 2023-03-29 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
US11357849B2 (en) | 2016-03-07 | 2022-06-14 | Musc Foundation For Research Development | Anti-nucleolin antibodies |
US10336784B2 (en) | 2016-03-08 | 2019-07-02 | Academia Sinica | Methods for modular synthesis of N-glycans and arrays thereof |
EP4302782A2 (en) | 2016-03-15 | 2024-01-10 | Mersana Therapeutics, Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
WO2017159699A1 (en) | 2016-03-15 | 2017-09-21 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
EP4112641A1 (en) | 2016-03-15 | 2023-01-04 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
WO2017160754A1 (en) | 2016-03-15 | 2017-09-21 | Mersana Therapeutics,Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
EP4275745A2 (en) | 2016-03-17 | 2023-11-15 | Tillotts Pharma Ag | Anti-tnfalpha-antibodies and functional fragments thereof |
WO2017158097A1 (en) | 2016-03-17 | 2017-09-21 | Tillotts Pharma Ag | Anti-tnfalpha-antibodies and functional fragments thereof |
EP3219727A1 (en) | 2016-03-17 | 2017-09-20 | Tillotts Pharma AG | Anti-tnf alpha-antibodies and functional fragments thereof |
WO2017158079A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | Anti-tnfalpha-antibodies and functional fragments thereof |
WO2017158092A1 (en) | 2016-03-17 | 2017-09-21 | Tillotts Pharma Ag | Anti-tnfalpha-antibodies and functional fragments thereof |
WO2017158084A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF |
WO2017158101A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF |
EP3219726A1 (en) | 2016-03-17 | 2017-09-20 | Tillotts Pharma AG | Anti-tnf alpha-antibodies and functional fragments thereof |
US10745487B2 (en) | 2016-03-22 | 2020-08-18 | Bionomics Limited | Method of treating cancer by administering an anti-LGR5 monoclonal antibody |
WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
US11833223B2 (en) | 2016-03-29 | 2023-12-05 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
WO2017172771A2 (en) | 2016-03-29 | 2017-10-05 | Janssen Biotech, Inc. | Method of treating psoriasis with increased interval dosing of anti-il12/23 antibody |
WO2017175058A1 (en) | 2016-04-07 | 2017-10-12 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
WO2017181111A2 (en) | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
WO2017181079A2 (en) | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Methods for monitoring and treating cancer |
WO2017182427A1 (en) | 2016-04-19 | 2017-10-26 | Amgen Research (Munich) Gmbh | Administration of a bispecific construct binding to cd33 and cd3 for use in a method for the treatment of myeloid leukemia |
US11053318B2 (en) | 2016-04-19 | 2021-07-06 | Amgen Research (Munich) Gmbh | Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia |
US11583577B2 (en) | 2016-04-22 | 2023-02-21 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via Globo series antigens |
WO2017185089A2 (en) | 2016-04-22 | 2017-10-26 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
WO2017196902A2 (en) | 2016-05-10 | 2017-11-16 | Genentech, Inc. | Methods of decreasing trisulfide bonds during recombinant production of polypeptides |
US11535670B2 (en) | 2016-05-11 | 2022-12-27 | Huyabio International, Llc | Combination therapies of HDAC inhibitors and PD-L1 inhibitors |
WO2017197153A1 (en) | 2016-05-11 | 2017-11-16 | Huya Bioscien International, Llc | Combination therapies of hdac inhibitors pd-1 inhibitors |
WO2017194568A1 (en) | 2016-05-11 | 2017-11-16 | Sanofi | Treatment regimen using anti-muc1 maytansinoid immunoconjugate antibody for the treatment of tumors |
EP4233909A2 (en) | 2016-05-17 | 2023-08-30 | AbbVie Biotherapeutics Inc. | Anti-cmet antibody drug conjugates and methods for their use |
EP3804765A1 (en) | 2016-05-17 | 2021-04-14 | AbbVie Biotherapeutics Inc. | Anti-cmet antibody drug conjugates and methods for their use |
EP3626273A1 (en) | 2016-05-17 | 2020-03-25 | AbbVie Biotherapeutics Inc. | Anti-cmet antibody drug conjugates and methods for their use |
WO2017201204A1 (en) | 2016-05-17 | 2017-11-23 | Abbvie Biotherapeutics Inc. | ANTI-cMet ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE |
US11649291B2 (en) | 2016-05-24 | 2023-05-16 | Insmed Incorporated | Antibodies and methods of making same |
WO2017202744A1 (en) | 2016-05-26 | 2017-11-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
EP3995511A1 (en) | 2016-05-27 | 2022-05-11 | AbbVie Biotherapeutics Inc. | Anti-cd40 antibodies and their uses |
WO2017205742A1 (en) | 2016-05-27 | 2017-11-30 | Abbvie Biotherapeutics Inc. | Anti-cd40 antibodies and their uses |
US10875921B2 (en) | 2016-05-27 | 2020-12-29 | Abbvie Biotherapeutics Inc. | Anti-4-1BB antibodies and their uses |
WO2017205745A1 (en) | 2016-05-27 | 2017-11-30 | Abbvie Biotherapeutics Inc. | Anti-4-1bb antibodies and their uses |
WO2017205721A1 (en) | 2016-05-27 | 2017-11-30 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
WO2017215590A1 (en) | 2016-06-13 | 2017-12-21 | I-Mab | Anti-pd-l1 antibodies and uses thereof |
US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
US11865173B2 (en) | 2016-06-15 | 2024-01-09 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
WO2018007999A1 (en) | 2016-07-08 | 2018-01-11 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
US11447573B2 (en) | 2016-07-20 | 2022-09-20 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
WO2018018011A2 (en) | 2016-07-22 | 2018-01-25 | Amgen Inc. | Methods of purifying fc-containing proteins |
US11642400B2 (en) | 2016-07-27 | 2023-05-09 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
US11643456B2 (en) | 2016-07-29 | 2023-05-09 | Obi Pharma, Inc. | Human antibodies, pharmaceutical compositions and methods |
WO2018020476A1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings, Europe B.V. | Anti-pd-1 antibodies |
US10494436B2 (en) | 2016-07-29 | 2019-12-03 | Aduro Biotech Holdings, Europe B.V. | Anti-PD-1 antibodies |
US10519250B2 (en) | 2016-08-01 | 2019-12-31 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof |
US11787876B2 (en) | 2016-08-01 | 2023-10-17 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof |
WO2018026748A1 (en) | 2016-08-01 | 2018-02-08 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof |
WO2018025178A1 (en) | 2016-08-02 | 2018-02-08 | Aduro Biotech Holdings, Europe B.V. | Antibodies against human ctla-4 |
US10808030B2 (en) | 2016-08-02 | 2020-10-20 | Aduro Biotech Holdings, Europe B.V. | Anti-HCTLA-4 antibodies |
WO2018029124A1 (en) | 2016-08-08 | 2018-02-15 | F. Hoffmann-La Roche Ag | Therapeutic and diagnostic methods for cancer |
WO2018031865A1 (en) | 2016-08-12 | 2018-02-15 | Genentech, Inc. | Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a vegf inhibitor |
US10538592B2 (en) | 2016-08-22 | 2020-01-21 | Cho Pharma, Inc. | Antibodies, binding fragments, and methods of use |
WO2018049261A1 (en) | 2016-09-09 | 2018-03-15 | Icellhealth Consulting Llc | Oncolytic virus expressing immune checkpoint modulators |
WO2018049248A1 (en) | 2016-09-09 | 2018-03-15 | Icellhealth Consulting Llc | Oncolytic virus equipped with bispecific engager molecules |
EP3778643A1 (en) | 2016-09-14 | 2021-02-17 | AbbVie Biotherapeutics Inc. | Pharmaceutical uses of anti-pd-1(cd279) antibodies |
WO2018053106A1 (en) | 2016-09-14 | 2018-03-22 | Abbvie Biotherapeutics Inc. | Anti-pd-1(cd279) antibodies |
WO2018050111A1 (en) | 2016-09-19 | 2018-03-22 | I-Mab | Anti-gm-csf antibodies and uses thereof |
EP4119580A1 (en) | 2016-09-21 | 2023-01-18 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
US11242404B2 (en) | 2016-09-21 | 2022-02-08 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
WO2018057669A1 (en) | 2016-09-21 | 2018-03-29 | Alexo Therapeutics Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
WO2018057735A1 (en) | 2016-09-21 | 2018-03-29 | Nextcure, Inc. | Antibodies for siglec-15 and methods of use thereof |
US11401338B2 (en) | 2016-09-21 | 2022-08-02 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
US10858428B2 (en) | 2016-09-28 | 2020-12-08 | Xoma (Us) Llc | Antibodies that bind interleukin-2 and uses thereof |
WO2018064255A2 (en) | 2016-09-28 | 2018-04-05 | Xoma (Us) Llc | Antibodies that bind interleukin-2 and uses thereof |
WO2018064299A1 (en) | 2016-09-29 | 2018-04-05 | Genentech, Inc. | Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a taxane |
WO2018064436A1 (en) | 2016-09-30 | 2018-04-05 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il23 specific antibody |
WO2018067468A1 (en) | 2016-10-03 | 2018-04-12 | Abbott Laboratories | Improved methods of assessing uch-l1 status in patient samples |
WO2018067474A1 (en) | 2016-10-03 | 2018-04-12 | Abbott Laboratories | Improved methods of assessing gfap status in patient samples |
WO2018068028A1 (en) | 2016-10-06 | 2018-04-12 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
US11274154B2 (en) | 2016-10-06 | 2022-03-15 | Pfizer Inc. | Dosing regimen of avelumab for the treatment of cancer |
US11472881B2 (en) | 2016-10-11 | 2022-10-18 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against CTLA-4 |
US10844119B2 (en) | 2016-10-11 | 2020-11-24 | Agenus Inc. | Anti-LAG-3 antibodies and methods of use thereof |
US10882908B2 (en) | 2016-10-11 | 2021-01-05 | Agenus Inc. | Anti-LAG-3 antibodies and methods of use thereof |
WO2018071500A1 (en) | 2016-10-11 | 2018-04-19 | Agenus Inc. | Anti-lag-3 antibodies and methods of use thereof |
WO2018081578A1 (en) | 2016-10-28 | 2018-05-03 | Astute Medical, Inc. | Use of antibodies to timp-2 for the improvement of renal function |
WO2018081531A2 (en) | 2016-10-28 | 2018-05-03 | Ariad Pharmaceuticals, Inc. | Methods for human t-cell activation |
WO2018085359A1 (en) | 2016-11-02 | 2018-05-11 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and parp inhibitors |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
WO2018083538A1 (en) | 2016-11-07 | 2018-05-11 | Neuracle Scienc3 Co., Ltd. | Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof |
WO2018087285A1 (en) | 2016-11-10 | 2018-05-17 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Or10h1 antigen binding proteins and uses thereof |
WO2018090052A1 (en) | 2016-11-14 | 2018-05-17 | Amgen Inc. | Bispecific or biparatopic antigen binding proteins and uses thereof |
WO2018093841A1 (en) | 2016-11-16 | 2018-05-24 | Janssen Biotech, Inc. | Method of treating psoriasis with anti-il-23 specific antibody |
US11208474B2 (en) | 2016-11-16 | 2021-12-28 | Janssen Biotech, Inc. | Method of treating psoriasis with anti-IL23 specific antibody |
US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
US11000601B2 (en) | 2016-11-21 | 2021-05-11 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
WO2018098401A1 (en) | 2016-11-23 | 2018-05-31 | Translational Drug Development, Llc | Benzamide and active compound compositions and methods of use |
EP4289484A2 (en) | 2016-12-07 | 2023-12-13 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
WO2018106862A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
WO2018106864A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
EP3725809A1 (en) | 2016-12-15 | 2020-10-21 | AbbVie Biotherapeutics Inc. | Anti-ox40 antibodies and their uses |
WO2018112346A1 (en) | 2016-12-15 | 2018-06-21 | Abbvie Biotherapeutics Inc. | Anti-ox40 antibodies and their uses |
WO2018122043A1 (en) | 2016-12-27 | 2018-07-05 | F. Hoffmann-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
WO2018122205A2 (en) | 2016-12-27 | 2018-07-05 | F. Hoffmann-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
WO2018122204A1 (en) | 2016-12-27 | 2018-07-05 | F. Hoffmann-La Roche Ag | Novel biotin-specific monoclonal antibody and use thereof |
WO2018127570A1 (en) | 2017-01-05 | 2018-07-12 | Netris Pharma | Combined treatment with netrin-1 interfering drug and immune checkpoint inhibitors drugs |
US10905772B2 (en) | 2017-01-17 | 2021-02-02 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using GLP-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (GIPR) |
US10465007B2 (en) | 2017-01-20 | 2019-11-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-PD-1 antibodies and uses thereof |
US11560430B2 (en) | 2017-01-20 | 2023-01-24 | Tayu Huaxia Biotech Medical Group Co., LTD | Anti-PD-1 antibodies and uses thereof |
WO2018137598A1 (en) | 2017-01-24 | 2018-08-02 | I-Mab | Anti-cd73 antibodies and uses thereof |
EP4050030A1 (en) | 2017-01-24 | 2022-08-31 | I-Mab Biopharma US Limited | Anti-cd73 antibodies and uses thereof |
WO2018140026A1 (en) | 2017-01-27 | 2018-08-02 | Memorial Sloan Kettering Cancer Center | Bispecific her2 and cd3 binding molecules |
US11041020B2 (en) | 2017-01-30 | 2021-06-22 | Janssen Biotech, Inc. | Methods for the treatment of active Psoriatic Arthritis |
WO2018141910A1 (en) | 2017-02-02 | 2018-08-09 | Amgen Research (Munich) Gmbh | Low ph pharmaceutical composition comprising t cell engaging antibody constructs |
WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
US11099180B2 (en) | 2017-02-02 | 2021-08-24 | Roche Diagnostics Operations, Inc. | Immunoassay using at least two pegylated analyte-specific binding agents |
US11014982B2 (en) | 2017-02-07 | 2021-05-25 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, and methods for the treatment of active ankylosing spondylitis |
WO2018153320A1 (en) | 2017-02-21 | 2018-08-30 | 上海君实生物医药科技股份有限公司 | Anti-pd-l1 antibody and application thereof |
WO2018160841A1 (en) | 2017-03-01 | 2018-09-07 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
US11253609B2 (en) | 2017-03-03 | 2022-02-22 | Seagen Inc. | Glycan-interacting compounds and methods of use |
US10842869B2 (en) | 2017-03-22 | 2020-11-24 | Sanofi | Method of treating lupus by administering humanized anti-CXCR5 (C-X-C motif chemokine receptor 5) antibodies |
WO2018172465A1 (en) | 2017-03-22 | 2018-09-27 | Sanofi | Treatment of lupus using humanized anti-cxcr5 antibodies |
WO2018175942A1 (en) | 2017-03-23 | 2018-09-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
US11644468B2 (en) | 2017-03-30 | 2023-05-09 | Progastrine et Cancers S.à r.L | Compositions and methods for detecting and treating prostate cancer using progastrin binding molecule |
WO2018178352A1 (en) | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting prostate cancer |
US11614448B2 (en) | 2017-03-30 | 2023-03-28 | Ecs-Progastrin Sa | Compositions and methods for detecting prostate cancer |
US11561225B2 (en) | 2017-03-30 | 2023-01-24 | Progastrine Et Cancers S.À R.L. | Compositions and methods for treating lung cancer |
WO2018178354A1 (en) | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting lung cancer |
WO2018178363A1 (en) | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating prostate cancer using progastrin binding molecule |
WO2018178364A1 (en) | 2017-03-30 | 2018-10-04 | Progastrine Et Cancers S.À R.L. | Compositions and methods for treating lung cancer |
US11913958B2 (en) | 2017-03-30 | 2024-02-27 | Ecs-Progastrin Sa | Compositions and methods for detecting lung cancer |
WO2018178040A1 (en) | 2017-03-30 | 2018-10-04 | Merck Patent Gmbh | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
WO2018191502A2 (en) | 2017-04-13 | 2018-10-18 | Agenus Inc. | Anti-cd137 antibodies and methods of use thereof |
WO2018191531A1 (en) | 2017-04-15 | 2018-10-18 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
WO2018195527A1 (en) | 2017-04-22 | 2018-10-25 | Immunomic Therapeutics, Inc. | Improved lamp constructs |
WO2018196782A1 (en) | 2017-04-27 | 2018-11-01 | The University Of Hong Kong | Use of hcn inhibitors for treatment of cancer |
WO2018200823A1 (en) | 2017-04-28 | 2018-11-01 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
EP4275698A2 (en) | 2017-05-01 | 2023-11-15 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
WO2018204363A1 (en) | 2017-05-01 | 2018-11-08 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
WO2018204534A1 (en) | 2017-05-02 | 2018-11-08 | Immunomic Therapeutics, Inc. | Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens |
WO2018204907A1 (en) | 2017-05-05 | 2018-11-08 | Amgen Inc. | Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration |
US11918650B2 (en) | 2017-05-05 | 2024-03-05 | Amgen Inc. | Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration |
US10865238B1 (en) | 2017-05-05 | 2020-12-15 | Duke University | Complement factor H antibodies |
WO2018209194A2 (en) | 2017-05-12 | 2018-11-15 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
US11359014B2 (en) | 2017-05-16 | 2022-06-14 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
WO2018213316A1 (en) | 2017-05-16 | 2018-11-22 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
US10914729B2 (en) | 2017-05-22 | 2021-02-09 | The Trustees Of Princeton University | Methods for detecting protein binding sequences and tagging nucleic acids |
WO2018218169A1 (en) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
WO2018222784A1 (en) | 2017-05-30 | 2018-12-06 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i |
WO2018222783A1 (en) | 2017-05-30 | 2018-12-06 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers |
WO2018222685A1 (en) | 2017-05-31 | 2018-12-06 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1 |
US11897963B2 (en) | 2017-05-31 | 2024-02-13 | Amgen Inc. | Anti-Jagged1 antigen binding proteins |
WO2018222689A1 (en) | 2017-05-31 | 2018-12-06 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
US11028180B2 (en) | 2017-05-31 | 2021-06-08 | Amgen Inc. | Anti-Jagged1 antigen binding proteins |
WO2018222770A1 (en) | 2017-05-31 | 2018-12-06 | Amgen Inc. | Anti-jagged1 antigen binding proteins |
US11897965B2 (en) | 2017-05-31 | 2024-02-13 | Amgen Inc. | Anti-Jagged1 antigen binding proteins |
US11542331B2 (en) | 2017-06-06 | 2023-01-03 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to BTN1A1 or BTN1A1-ligands |
WO2018226671A1 (en) | 2017-06-06 | 2018-12-13 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands |
WO2018237097A1 (en) | 2017-06-20 | 2018-12-27 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
US11827713B2 (en) | 2017-06-27 | 2023-11-28 | Nanjing Legend Biotech Co., Ltd. | Chimeric antibody immune effector cell engagers and methods of use thereof |
US11802156B2 (en) | 2017-07-14 | 2023-10-31 | Pfizer Inc. | Antibodies to MAdCAM |
WO2019014572A1 (en) | 2017-07-14 | 2019-01-17 | Pfizer, Inc. | Antibodies to madcam |
WO2019018757A1 (en) | 2017-07-21 | 2019-01-24 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2019023460A1 (en) | 2017-07-27 | 2019-01-31 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
US10676525B2 (en) | 2017-08-03 | 2020-06-09 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
US11254743B2 (en) | 2017-08-03 | 2022-02-22 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
WO2019028283A1 (en) | 2017-08-03 | 2019-02-07 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
EP4248996A2 (en) | 2017-08-03 | 2023-09-27 | Alector LLC | Anti-trem2 antibodies and methods of use thereof |
WO2019028292A1 (en) | 2017-08-03 | 2019-02-07 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
US10711062B2 (en) | 2017-08-03 | 2020-07-14 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
US11634489B2 (en) | 2017-08-03 | 2023-04-25 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
WO2019028382A1 (en) | 2017-08-04 | 2019-02-07 | Amgen Inc. | Method of conjugation of cys-mabs |
US11578426B2 (en) | 2017-08-21 | 2023-02-14 | Adagene Inc. | Dynamic human heavy chain antibody libraries |
US11585014B2 (en) | 2017-08-21 | 2023-02-21 | Adagene Inc. | Dynamic human antibody light chain libraries |
WO2019051164A1 (en) | 2017-09-07 | 2019-03-14 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
WO2019059411A1 (en) | 2017-09-20 | 2019-03-28 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent |
WO2019057816A1 (en) | 2017-09-22 | 2019-03-28 | F. Hoffmann-La Roche Ag | Multivalent mono- or bispecific recombinant antibodies for analytic purpose |
WO2019058345A2 (en) | 2017-09-25 | 2019-03-28 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
US11230601B2 (en) | 2017-10-10 | 2022-01-25 | Tilos Therapeutics, Inc. | Methods of using anti-lap antibodies |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | Anti-lap antibodies and uses thereof |
US11912754B2 (en) | 2017-10-12 | 2024-02-27 | Immunowake Inc. | VEGFR-antibody light chain fusion protein |
WO2019083904A1 (en) | 2017-10-23 | 2019-05-02 | Chan Zuckerberg Biohub, Inc. | Measurement of afucosylated igg fc glycans and related treatment methods |
WO2019084460A1 (en) | 2017-10-26 | 2019-05-02 | The Regents Of The University Of California | Inhibition of oxidation-specific epitopes to treat ischemic reperfusion injury |
WO2019089594A1 (en) | 2017-10-31 | 2019-05-09 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and cytarabine |
WO2019087115A1 (en) | 2017-10-31 | 2019-05-09 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
WO2019090263A1 (en) | 2017-11-06 | 2019-05-09 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
US11401345B2 (en) | 2017-11-27 | 2022-08-02 | Purdue Pharma L.P. | Humanized antibodies targeting human tissue factor |
WO2019102435A1 (en) | 2017-11-27 | 2019-05-31 | Euro-Celtique S.A. | Humanized antibodies targeting human tissue factor |
US11046758B2 (en) | 2017-12-05 | 2021-06-29 | Progastrine Et Cancers S.À R.L. | Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer |
WO2019110662A1 (en) | 2017-12-05 | 2019-06-13 | Progastrine Et Cancers S.À R.L. | Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer |
WO2019113375A2 (en) | 2017-12-06 | 2019-06-13 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
WO2019113525A2 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1) |
WO2019112860A1 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
WO2019118426A1 (en) | 2017-12-11 | 2019-06-20 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
EP4295915A2 (en) | 2017-12-20 | 2023-12-27 | Harbour Biomed (Shanghai) Co., Ltd | Antibodies binding ctla-4 and uses thereof |
WO2019120232A1 (en) | 2017-12-20 | 2019-06-27 | Harbour Biomed (Shanghai) Co., Ltd | Antibodies binding ctla-4 and uses thereof |
US11891439B2 (en) | 2017-12-28 | 2024-02-06 | Astute Medical, Inc. | Antibodies and assays for CCL14 |
US11905327B2 (en) | 2017-12-28 | 2024-02-20 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against TIGIT |
WO2019129211A1 (en) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Antibodies and variants thereof against pd-l1 |
WO2019133961A1 (en) | 2017-12-29 | 2019-07-04 | Amgen Inc. | Bispecific antibody construct directed to muc17 and cd3 |
EP3508499A1 (en) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
WO2019134991A1 (en) | 2018-01-08 | 2019-07-11 | Iomx Therapeutics Ag | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
WO2019140216A1 (en) | 2018-01-12 | 2019-07-18 | Amgen Inc. | Pac1 antibodies and uses thereof |
US11713353B2 (en) | 2018-01-15 | 2023-08-01 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against PD-1 |
WO2019145537A1 (en) | 2018-01-26 | 2019-08-01 | Ecs-Progastrin Sa | Combination of progastrin detection with other cancer biomarkers in cancer diagnosis |
WO2019165434A1 (en) | 2018-02-26 | 2019-08-29 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2019166499A1 (en) | 2018-02-27 | 2019-09-06 | Ecs-Progastrin Sa | Progastrin as a biomarker for immunotherapy |
WO2019169229A1 (en) | 2018-03-01 | 2019-09-06 | Nextcure, Inc. | Klrg1 binding compositions and methods of use thereof |
WO2019168403A2 (en) | 2018-03-02 | 2019-09-06 | Labo Bio-Medical Investments B.V. | Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders |
WO2019171252A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
US10982002B2 (en) | 2018-03-12 | 2021-04-20 | Zoetis Services Llc | Anti-NGF antibodies and methods thereof |
US11485782B2 (en) | 2018-03-14 | 2022-11-01 | Beijing Xuanyi Pharmasciences Co., Ltd. | Anti-claudin 18.2 antibodies |
US11939393B2 (en) | 2018-03-21 | 2024-03-26 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
US11292850B2 (en) | 2018-03-21 | 2022-04-05 | ALX Oncology Inc. | Antibodies against signal-regulatory protein α and methods of use |
EP4144372A2 (en) | 2018-03-21 | 2023-03-08 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
US11576984B2 (en) | 2018-03-26 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with humanized immunoglobulin heavy chain constant region genes and method of using |
WO2019197651A1 (en) | 2018-04-12 | 2019-10-17 | Mediapharma S.R.L. | Lgals3bp antibody-drug-conjugate and its use for the treatment of cancer |
WO2019207159A1 (en) | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
WO2019211489A1 (en) | 2018-05-04 | 2019-11-07 | Merck Patent Gmbh | COMBINED INHIBITION OF PD-1/PD-L1, TGFβ AND DNA-PK FOR THE TREATMENT OF CANCER |
WO2019215701A1 (en) | 2018-05-11 | 2019-11-14 | Janssen Biotech, Inc. | Methods of treating depression using il-23 antibodies |
WO2019222130A1 (en) | 2018-05-15 | 2019-11-21 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and flt3 inhibitors |
WO2019222281A1 (en) | 2018-05-15 | 2019-11-21 | Immunomic Therapeutics, Inc | Improved lamp constructs comprising allergens |
WO2019226973A1 (en) | 2018-05-25 | 2019-11-28 | Alector Llc | Anti-sirpa antibodies and methods of use thereof |
WO2019236965A1 (en) | 2018-06-08 | 2019-12-12 | Alector Llc | Anti-siglec-7 antibodies and methods of use thereof |
US11241417B2 (en) | 2018-06-21 | 2022-02-08 | Yumanity Therapeutics, Inc. | Compositions and methods for the treatment and prevention of neurological disorders |
WO2019246557A1 (en) | 2018-06-23 | 2019-12-26 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor |
US11203645B2 (en) | 2018-06-27 | 2021-12-21 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
US11884729B2 (en) | 2018-06-29 | 2024-01-30 | ApitBio, Inc | Anti-L1CAM antibodies and uses thereof |
US11396546B2 (en) | 2018-07-13 | 2022-07-26 | Alector Llc | Anti-Sortilin antibodies and methods of use thereof |
WO2020018789A1 (en) | 2018-07-18 | 2020-01-23 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent |
WO2020016838A2 (en) | 2018-07-18 | 2020-01-23 | Janssen Biotech, Inc. | Sustained response predictors after treatment with anti-il23 specific antibody |
WO2020016459A1 (en) | 2018-07-20 | 2020-01-23 | Pierre Fabre Medicament | Receptor for vista |
WO2020023920A1 (en) | 2018-07-27 | 2020-01-30 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
WO2020025532A1 (en) | 2018-07-30 | 2020-02-06 | Amgen Research (Munich) Gmbh | Prolonged administration of a bispecific antibody construct binding to cd33 and cd3 |
US11692031B2 (en) | 2018-08-03 | 2023-07-04 | Amgen Research (Munich) Gmbh | Antibody constructs for CLDN18.2 and CD3 |
WO2020025792A1 (en) | 2018-08-03 | 2020-02-06 | Amgen Research (Munich) Gmbh | Antibody constructs for cldn18.2 and cd3 |
WO2020033485A1 (en) | 2018-08-08 | 2020-02-13 | Genentech, Inc. | Use of tryptophan derivatives and l-methionine for protein formulation |
WO2020043670A1 (en) | 2018-08-27 | 2020-03-05 | Affimed Gmbh | Cryopreserved nk cells preloaded with an antibody construct |
WO2020061060A1 (en) | 2018-09-19 | 2020-03-26 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
WO2020061349A1 (en) | 2018-09-21 | 2020-03-26 | Genentech, Inc. | Diagnostic methods for triple-negative breast cancer |
EP4249917A2 (en) | 2018-09-21 | 2023-09-27 | F. Hoffmann-La Roche AG | Diagnostic methods for triple-negative breast cancer |
WO2020065532A1 (en) | 2018-09-24 | 2020-04-02 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
WO2020064971A1 (en) | 2018-09-26 | 2020-04-02 | Merck Patent Gmbh | Combination of a pd-1 antagonist, an atr inhibitor and a platinating agent for the treatment of cancer |
WO2020070678A2 (en) | 2018-10-03 | 2020-04-09 | Staten Biotechnology B.V. | Antibodies specific for human and cynomolgus apoc3 and methods of use thereof |
US11130802B2 (en) | 2018-10-10 | 2021-09-28 | Tilos Therapeutics, Inc. | Anti-lap antibody variants |
WO2020076969A2 (en) | 2018-10-10 | 2020-04-16 | Tilos Therapeutics, Inc. | Anti-lap antibody variants and uses thereof |
WO2020077212A1 (en) | 2018-10-11 | 2020-04-16 | Amgen Inc. | Downstream processing of bispecific antibody constructs |
WO2020078905A1 (en) | 2018-10-15 | 2020-04-23 | Merck Patent Gmbh | Combination therapy utilizing dna alkylating agents and atr inhibitors |
WO2020081767A1 (en) | 2018-10-18 | 2020-04-23 | Genentech, Inc. | Diagnostic and therapeutic methods for sarcomatoid kidney cancer |
EP3811969A1 (en) | 2018-10-24 | 2021-04-28 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Immunization scheme for variant surface glycoprotein carriers |
WO2021214043A1 (en) | 2018-10-24 | 2021-10-28 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Immunization scheme for variant surface glycoprotein carriers |
WO2020092455A2 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Car t cell transcriptional atlas |
WO2020096959A1 (en) | 2018-11-05 | 2020-05-14 | Genentech, Inc. | Methods of producing two chain proteins in prokaryotic host cells |
WO2020099533A1 (en) | 2018-11-16 | 2020-05-22 | F. Hoffmann-La Roche Ag | Streptavidin-coated solid phases with a member of a binding pair |
US11548941B2 (en) | 2018-11-20 | 2023-01-10 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-IL-23 specific antibody |
WO2020104943A2 (en) | 2018-11-20 | 2020-05-28 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il-23 specific antibody |
WO2020118011A1 (en) | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
WO2020118293A2 (en) | 2018-12-07 | 2020-06-11 | Georgia Tech Research Corporation | Antibodies that bind to natively folded myocilin |
WO2020128864A1 (en) | 2018-12-18 | 2020-06-25 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-il12/il23 antibody |
WO2020150152A1 (en) | 2019-01-14 | 2020-07-23 | Genentech, Inc. | Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine |
WO2020148651A1 (en) | 2019-01-15 | 2020-07-23 | Janssen Biotech, Inc. | Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis |
WO2020154410A1 (en) | 2019-01-23 | 2020-07-30 | Genentech, Inc. | Methods of producing multimeric proteins in eukaryotic host cells |
WO2020152544A1 (en) | 2019-01-23 | 2020-07-30 | Janssen Biotech, Inc. | Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis |
WO2020159504A1 (en) | 2019-01-30 | 2020-08-06 | Nomocan Pharmaceuticals Llc | Antibodies to m(h)dm2/4 and their use in diagnosing and treating cancer |
WO2020163589A1 (en) | 2019-02-08 | 2020-08-13 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
WO2020168555A1 (en) | 2019-02-22 | 2020-08-27 | 武汉友芝友生物制药有限公司 | Cd3 antigen binding fragment and application thereof |
WO2020176497A1 (en) | 2019-02-26 | 2020-09-03 | Rgenix, Inc. | High-affinity anti-mertk antibodies and uses thereof |
WO2020176748A1 (en) | 2019-02-27 | 2020-09-03 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies |
WO2020183269A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
WO2020183271A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
WO2020183418A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-il12/il23 antibody compositions |
WO2020183270A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
US10934337B2 (en) | 2019-03-15 | 2021-03-02 | Cartesian Therapeutics, Inc. | Anti-BCMA chimeric antigen receptors |
US11220535B2 (en) | 2019-03-15 | 2022-01-11 | Cartesian Therapeutics, Inc. | Anti-BCMA chimeric antigen receptors |
WO2020188466A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Biotech, Inc. | Method of treating psoriasis in pediatric subjects with anti-il12/il23 antibody |
US11090336B2 (en) | 2019-03-27 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Tn-MUC1 chimeric antigen receptor (CAR) T cell therapy |
WO2020198731A2 (en) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Engineered antibodies |
WO2020216947A1 (en) | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
WO2020226986A2 (en) | 2019-05-03 | 2020-11-12 | Genentech, Inc. | Methods of treating cancer with an anti-pd-l1 antibody |
US11780911B2 (en) | 2019-05-23 | 2023-10-10 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
EP3741389A1 (en) | 2019-05-23 | 2020-11-25 | Fibrogen, Inc. | A connective tissue growth factor (ctgf) inhibitor for use in the treatment of muscular dystrophies |
WO2020243477A2 (en) | 2019-05-30 | 2020-12-03 | Amgen Inc. | Engineering the hinge region to drive antibody dimerization |
WO2020245677A1 (en) | 2019-06-03 | 2020-12-10 | Janssen Biotech, Inc. | Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis |
WO2020245676A1 (en) | 2019-06-03 | 2020-12-10 | Janssen Biotech, Inc. | Anti-tnf antibody compositions, and methods for the treatment of psoriatic arthritis |
WO2020252442A1 (en) | 2019-06-13 | 2020-12-17 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
WO2020264384A1 (en) | 2019-06-28 | 2020-12-30 | Amgen Inc. | Anti-cgrp receptor/anti-pac1 receptor bispecific antigen binding proteins |
WO2021001458A1 (en) | 2019-07-01 | 2021-01-07 | Tonix Pharma Holdings Limited | Anti-cd154 antibodies and uses thereof |
WO2022008514A1 (en) | 2019-07-05 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
WO2021005009A1 (en) | 2019-07-05 | 2021-01-14 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
EP3763737A1 (en) | 2019-07-12 | 2021-01-13 | Eberhard Karls Universität Tübingen | Binding compounds of penicillin binding protein 2 a |
WO2021021676A1 (en) | 2019-07-26 | 2021-02-04 | Amgen Inc. | Anti-il13 antigen binding proteins |
WO2021028752A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Anti-tfn antibodies for treating type i diabetes |
WO2021042019A1 (en) | 2019-08-30 | 2021-03-04 | Agenus Inc. | Anti-cd96 antibodies and methods of use thereof |
WO2021043206A1 (en) | 2019-09-03 | 2021-03-11 | 百奥泰生物制药股份有限公司 | Anti-tigit immunosuppressant and application thereof |
WO2021046159A1 (en) | 2019-09-04 | 2021-03-11 | Genentech, Inc. | Cd8 binding agents and uses thereof |
WO2021050640A1 (en) | 2019-09-10 | 2021-03-18 | Amgen Inc. | Purification method for bispecific antigen-binding polypeptides with enhanced protein l capture dynamic binding capacity |
WO2021050645A1 (en) | 2019-09-12 | 2021-03-18 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
WO2021062323A1 (en) | 2019-09-26 | 2021-04-01 | Stcube & Co. | Antibodies specific to glycosylated ctla-4 and methods of use thereof |
WO2021062085A1 (en) | 2019-09-27 | 2021-04-01 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2021072277A1 (en) | 2019-10-09 | 2021-04-15 | Stcube & Co. | Antibodies specific to glycosylated lag3 and methods of use thereof |
WO2021076930A1 (en) | 2019-10-18 | 2021-04-22 | The Regents Of The University Of California | Plxdc activators and their use in the treatment of blood vessel disorders |
WO2021077051A1 (en) | 2019-10-18 | 2021-04-22 | Immunomic Therapeutics, Inc | Improved lamp constructs comprising cancer antigens |
WO2021087406A1 (en) | 2019-11-01 | 2021-05-06 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
WO2021084124A1 (en) | 2019-11-01 | 2021-05-06 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFβ AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
WO2021089704A1 (en) | 2019-11-05 | 2021-05-14 | Merck Patent Gmbh | Combined inhibition of pd-1, tgfb and tigit for the treatment of cancer |
WO2021092171A1 (en) | 2019-11-06 | 2021-05-14 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
WO2021092355A1 (en) | 2019-11-08 | 2021-05-14 | Amgen Inc. | Engineering charge pair mutations for pairing of hetero-igg molecules |
WO2021097344A1 (en) | 2019-11-13 | 2021-05-20 | Amgen Inc. | Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules |
WO2021099347A1 (en) | 2019-11-18 | 2021-05-27 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
EP3822288A1 (en) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
WO2021099418A1 (en) | 2019-11-19 | 2021-05-27 | International - Drug - Development - Biotech | Anti-cd117 antibodies and methods of use thereof |
WO2021102049A1 (en) | 2019-11-19 | 2021-05-27 | Amgen Inc. | Novel multispecific antibody format |
EP3825330A1 (en) | 2019-11-19 | 2021-05-26 | International-Drug-Development-Biotech | Anti-cd117 antibodies and methods of use thereof |
WO2021113655A1 (en) | 2019-12-05 | 2021-06-10 | Alector Llc | Methods of use of anti-trem2 antibodies |
US11897950B2 (en) | 2019-12-06 | 2024-02-13 | Augusta University Research Institute, Inc. | Osteopontin monoclonal antibodies |
WO2021118930A2 (en) | 2019-12-09 | 2021-06-17 | Genentech, Inc. | Anti-pd-l1 antibody formulations |
WO2021119400A1 (en) | 2019-12-12 | 2021-06-17 | Alector Llc | Methods of use of anti-cd33 antibodies |
WO2021127528A1 (en) | 2019-12-20 | 2021-06-24 | Amgen Inc. | Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors |
WO2021130383A1 (en) | 2019-12-27 | 2021-07-01 | Affimed Gmbh | Method for the production of bispecific fcyriii x cd30 antibody construct |
WO2021142086A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
WO2021150824A1 (en) | 2020-01-22 | 2021-07-29 | Amgen Research (Munich) Gmbh | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
WO2021155149A1 (en) | 2020-01-31 | 2021-08-05 | Genentech, Inc. | Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine |
WO2021160133A1 (en) | 2020-02-13 | 2021-08-19 | 湖南华康恒健生物技术有限公司 | Anti-bcma antibody, pharmaceutical composition of same, and applications thereof |
WO2021173565A1 (en) | 2020-02-24 | 2021-09-02 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
WO2021178896A1 (en) | 2020-03-06 | 2021-09-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
WO2021183207A1 (en) | 2020-03-10 | 2021-09-16 | Massachusetts Institute Of Technology | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER |
WO2021183861A1 (en) | 2020-03-12 | 2021-09-16 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor |
WO2021188851A1 (en) | 2020-03-19 | 2021-09-23 | Amgen Inc. | Antibodies against mucin 17 and uses thereof |
WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2021202473A2 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Engineered antibodies |
WO2021197340A1 (en) | 2020-03-31 | 2021-10-07 | 百奥泰生物制药股份有限公司 | Antibody and fusion protein for treating coronaviruses and use thereof |
WO2021202959A1 (en) | 2020-04-03 | 2021-10-07 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
WO2021203030A2 (en) | 2020-04-03 | 2021-10-07 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2021207449A1 (en) | 2020-04-09 | 2021-10-14 | Merck Sharp & Dohme Corp. | Affinity matured anti-lap antibodies and uses thereof |
WO2021211331A1 (en) | 2020-04-13 | 2021-10-21 | Abbott Point Of Care Inc. | METHODS, COMPLEXES AND KITS FOR DETECTING OR DETERMINING AN AMOUNT OF A ß-CORONAVIRUS ANTIBODY IN A SAMPLE |
WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
WO2021222313A1 (en) | 2020-04-27 | 2021-11-04 | Magenta Therapeutics, Inc. | Methods and compositions for transducing hematopoietic stem and progenitor cells in vivo |
WO2021222181A2 (en) | 2020-04-27 | 2021-11-04 | The Regents Of The University Of California | Isoform-independent antibodies to lipoprotein(a) |
WO2021222167A1 (en) | 2020-04-28 | 2021-11-04 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
WO2021236638A1 (en) | 2020-05-19 | 2021-11-25 | Amgen Inc. | Mageb2 binding constructs |
EP3915641A1 (en) | 2020-05-27 | 2021-12-01 | International-Drug-Development-Biotech | Anti-cd5 antibodies and methods of use thereof |
WO2021243320A2 (en) | 2020-05-29 | 2021-12-02 | Amgen Inc. | Adverse effects-mitigating administration of a bispecific antibody construct binding to cd33 and cd3 |
WO2021247908A1 (en) | 2020-06-03 | 2021-12-09 | Bionecure Therapeutics, Inc. | Trophoblast cell-surface antigen-2 (trop-2) antibodies |
WO2021249969A1 (en) | 2020-06-10 | 2021-12-16 | Merck Patent Gmbh | Combination product for the treatment of cancer diseases |
WO2021257503A1 (en) | 2020-06-16 | 2021-12-23 | Genentech, Inc. | Methods and compositions for treating triple-negative breast cancer |
WO2021257124A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
WO2022006562A1 (en) | 2020-07-03 | 2022-01-06 | Dana-Farber Cancer Institute, Inc. | Multispecific coronavirus antibodies |
WO2022008027A1 (en) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
WO2022010797A2 (en) | 2020-07-07 | 2022-01-13 | Bionecure Therapeutics, Inc. | Novel maytansinoids as adc payloads and their use for the treatment of cancer |
WO2022020636A2 (en) | 2020-07-24 | 2022-01-27 | Amgen Inc. | Immunogens derived from sars-cov2 spike protein |
WO2022026699A1 (en) | 2020-07-31 | 2022-02-03 | Genentech, Inc. | Anti-integrin beta7 antibody formulations and devices |
WO2022031749A1 (en) | 2020-08-03 | 2022-02-10 | Genentech, Inc. | Diagnostic and therapeutic methods for lymphoma |
WO2022031804A1 (en) | 2020-08-04 | 2022-02-10 | Abbott Laboratories | Improved methods and kits for detecting sars-cov-2 protein in a sample |
WO2022028608A1 (en) | 2020-08-07 | 2022-02-10 | 百奥泰生物制药股份有限公司 | Anti pd-l1 antibody and application thereof |
WO2022036146A1 (en) | 2020-08-12 | 2022-02-17 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
WO2022040466A1 (en) | 2020-08-20 | 2022-02-24 | Amgen Inc. | Antigen binding proteins with non-canonical disulfide in fab region |
WO2022042659A1 (en) | 2020-08-26 | 2022-03-03 | 湖南华康恒健生物技术有限公司 | Anti-ox40 antibody, and pharmaceutical composition and application thereof |
WO2022047381A1 (en) | 2020-08-31 | 2022-03-03 | Genentech, Inc. | Methods for producing antibodies |
WO2022051549A1 (en) | 2020-09-04 | 2022-03-10 | Rutgers, The State University Of New Jersey | Sars-cov-2 vaccines and antibodies |
WO2022050954A1 (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
WO2022056490A1 (en) | 2020-09-14 | 2022-03-17 | Vor Biopharma, Inc. | Chimeric antigen receptors for treatment of cancer |
WO2022076474A2 (en) | 2020-10-07 | 2022-04-14 | Amgen Inc. | Rational selection of building blocks for the assembly of multispecific antibodies |
WO2022074206A1 (en) | 2020-10-08 | 2022-04-14 | Affimed Gmbh | Trispecific binders |
WO2022081436A1 (en) | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
WO2022087274A1 (en) | 2020-10-21 | 2022-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies that neutralize type-i interferon (ifn) activity |
WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
WO2022090529A1 (en) | 2020-11-02 | 2022-05-05 | Ares Trading S.A. | Combination treatment of cancer |
WO2022090527A1 (en) | 2020-11-02 | 2022-05-05 | Ares Trading S.A. | Combination treatment of cancer |
WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
EP3992205A1 (en) | 2020-11-03 | 2022-05-04 | Rheinische Friedrich-Wilhelms-Universität Bonn | Sars coronavirus-2 spike protein binding compounds |
WO2022096536A1 (en) | 2020-11-03 | 2022-05-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Target-cell restricted, costimulatory, bispecific and bivalent anti-cd28 antibodies |
WO2022096704A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Antigen binding domain with reduced clipping rate |
WO2022096700A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Research (Munich) Gmbh | Polypeptide constructs selectively binding to cldn6 and cd3 |
WO2022096716A2 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Multitargeting bispecific antigen-binding molecules of increased selectivity |
WO2022095970A1 (en) | 2020-11-06 | 2022-05-12 | 百奥泰生物制药股份有限公司 | Bispecific antibody and use thereof |
WO2022096698A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Polypeptide constructs binding to cd3 |
WO2022103773A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Novel linkers of multispecific antigen binding domains |
WO2022100694A1 (en) | 2020-11-12 | 2022-05-19 | 迈威(上海)生物科技股份有限公司 | Antibody and preparation method therefor |
WO2022106205A1 (en) | 2020-11-18 | 2022-05-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Corona virus spike protein binding compounds |
WO2022119841A1 (en) | 2020-12-01 | 2022-06-09 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
WO2022140797A1 (en) | 2020-12-23 | 2022-06-30 | Immunowake Inc. | Immunocytokines and uses thereof |
WO2022147147A1 (en) | 2020-12-30 | 2022-07-07 | Abbott Laboratories | Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample |
WO2022150452A1 (en) | 2021-01-06 | 2022-07-14 | Seth Lederman | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
WO2022162201A1 (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses |
WO2022162203A1 (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses |
WO2022187591A1 (en) | 2021-03-05 | 2022-09-09 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
WO2022192898A2 (en) | 2021-03-10 | 2022-09-15 | Immunowake Inc. | Immunomodulatory molecules and uses thereof |
WO2022190034A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody |
WO2022190033A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
WO2022198192A1 (en) | 2021-03-15 | 2022-09-22 | Genentech, Inc. | Compositions and methods of treating lupus nephritis |
WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
WO2022212831A1 (en) | 2021-04-02 | 2022-10-06 | Amgen Inc. | Mageb2 binding constructs |
WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
WO2022216898A1 (en) | 2021-04-09 | 2022-10-13 | Genentech, Inc. | Combination therapy with a raf inhibitor and a pd-1 axis inhibitor |
WO2022225921A1 (en) | 2021-04-20 | 2022-10-27 | Amgen Inc. | Balanced charge distribution in electrostatic steering of chain pairing in multi-specific and monovalent igg molecule assembly |
WO2022232376A1 (en) | 2021-04-29 | 2022-11-03 | Amgen Inc. | Methods for reducing low molecular weight species of recombinantly-produced proteins |
WO2022233718A2 (en) | 2021-05-03 | 2022-11-10 | Merck Patent Gmbh | Her2 targeting fc antigen binding fragment-drug conjugates |
WO2022235628A1 (en) | 2021-05-04 | 2022-11-10 | Regeneron Pharmaceuticals, Inc. | Multispecific fgf21 receptor agonists and their uses |
WO2022235940A1 (en) | 2021-05-06 | 2022-11-10 | Dana-Farber Cancer Institute, Inc. | Antibodies against alk and methods of use thereof |
WO2022234102A1 (en) | 2021-05-06 | 2022-11-10 | Amgen Research (Munich) Gmbh | Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases |
WO2022245920A1 (en) | 2021-05-18 | 2022-11-24 | Abbott Laboratories | Methods of evaluating brain injury in a pediatric subject |
WO2022248380A1 (en) | 2021-05-25 | 2022-12-01 | Merck Patent Gmbh | Egfr targeting fc antigen binding fragment-drug conjugates |
WO2022258622A1 (en) | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
WO2022263357A1 (en) | 2021-06-14 | 2022-12-22 | Argenx Iip Bv | Anti-il-9 antibodies and methods of use thereof |
WO2022266034A1 (en) | 2021-06-14 | 2022-12-22 | Abbott Laboratories | Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind |
WO2023281462A1 (en) | 2021-07-09 | 2023-01-12 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
WO2023281466A1 (en) | 2021-07-09 | 2023-01-12 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-il12/il23 antibody compositions |
WO2023281463A1 (en) | 2021-07-09 | 2023-01-12 | Janssen Biotech, Inc. | Manufacturing methods for producing anti-tnf antibody compositions |
WO2023010118A1 (en) | 2021-07-29 | 2023-02-02 | Vor Biopharma Inc. | Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same |
WO2023007023A1 (en) | 2021-07-30 | 2023-02-02 | Affimed Gmbh | Duplexbodies |
WO2023014863A1 (en) | 2021-08-05 | 2023-02-09 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
WO2023016826A2 (en) | 2021-08-05 | 2023-02-16 | Vaccinvent Gmbh | Method and means for enhancing therapeutic antibodies |
WO2023018803A1 (en) | 2021-08-10 | 2023-02-16 | Byomass Inc. | Anti-gdf15 antibodies, compositions and uses thereof |
WO2023023491A1 (en) | 2021-08-16 | 2023-02-23 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
WO2023023489A2 (en) | 2021-08-17 | 2023-02-23 | Hemogenyx Pharmaceuticals Llc | Bispecific anti-flt3/cd3 antibodies and methods of use |
WO2023034777A1 (en) | 2021-08-31 | 2023-03-09 | Abbott Laboratories | Methods and systems of diagnosing brain injury |
WO2023034569A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-cmet antibodies and their uses |
WO2023034571A1 (en) | 2021-09-03 | 2023-03-09 | Go Therapeutics, Inc. | Anti-glyco-lamp1 antibodies and their uses |
WO2023056268A1 (en) | 2021-09-30 | 2023-04-06 | Abbott Laboratories | Methods and systems of diagnosing brain injury |
WO2023069421A1 (en) | 2021-10-18 | 2023-04-27 | Byomass Inc. | Anti-activin a antibodies, compositions and uses thereof |
WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
WO2023073615A1 (en) | 2021-10-29 | 2023-05-04 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
WO2023079493A1 (en) | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Bispecific cd16a binders |
WO2023078968A1 (en) | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Bispecific cd16a binders |
WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
WO2023084488A1 (en) | 2021-11-15 | 2023-05-19 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
WO2023095000A1 (en) | 2021-11-23 | 2023-06-01 | Janssen Biotech, Inc. | Method of treating ulcerative colitis with anti-il23 specific antibody |
WO2023097024A1 (en) | 2021-11-24 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Antibodies against ctla-4 and methods of use thereof |
WO2023102384A1 (en) | 2021-11-30 | 2023-06-08 | Abbott Laboratories | Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi |
WO2023114544A1 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Antibodies and uses thereof |
WO2023114978A1 (en) | 2021-12-17 | 2023-06-22 | Abbott Laboratories | Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples |
WO2023111168A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
WO2023114543A2 (en) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Platform for antibody discovery |
WO2023122213A1 (en) | 2021-12-22 | 2023-06-29 | Byomass Inc. | Targeting gdf15-gfral pathway cross-reference to related applications |
WO2023129942A1 (en) | 2021-12-28 | 2023-07-06 | Abbott Laboratories | Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan |
WO2023139292A1 (en) | 2022-01-24 | 2023-07-27 | Cambridge Enterprise Limited | Tau therapy |
WO2023147107A1 (en) | 2022-01-31 | 2023-08-03 | Byomass Inc. | Myeloproliferative conditions |
WO2023150652A1 (en) | 2022-02-04 | 2023-08-10 | Abbott Laboratories | Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample |
WO2023164516A1 (en) | 2022-02-23 | 2023-08-31 | Alector Llc | Methods of use of anti-trem2 antibodies |
WO2023169896A1 (en) | 2022-03-09 | 2023-09-14 | Astrazeneca Ab | BINDING MOLECULES AGAINST FRα |
WO2023170216A1 (en) | 2022-03-11 | 2023-09-14 | Astrazeneca Ab | A SCORING METHOD FOR AN ANTI-FRα ANTIBODY-DRUG CONJUGATE THERAPY |
EP4245772A1 (en) | 2022-03-18 | 2023-09-20 | Netris Pharma | Anti-netrin-1 antibody to treat liver inflammation |
EP4249509A1 (en) | 2022-03-22 | 2023-09-27 | Netris Pharma | Anti-netrin-1 antibody against arthritis-associated pain |
WO2023180276A1 (en) | 2022-03-22 | 2023-09-28 | Netris Pharma | Anti-netrin-1 antibody against arthritis-associated pain |
WO2023186968A1 (en) | 2022-03-29 | 2023-10-05 | Netris Pharma | Novel mcl-1 inhibitor and combination of mcl-1 and a bh3 mimetic, such as a bcl-2 inhibitor |
WO2023187707A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of treating mild to moderate psoriasis with il-23 specific antibody |
WO2023194539A1 (en) | 2022-04-07 | 2023-10-12 | Heidelberg Pharma Research Gmbh | Methods of improving the therapeutic index of amatoxin-antibody conjugates |
WO2023201201A1 (en) | 2022-04-10 | 2023-10-19 | Immunomic Therapeutics, Inc. | Bicistronic lamp constructs comprising immune response enhancing genes and methods of use thereof |
WO2023215498A2 (en) | 2022-05-05 | 2023-11-09 | Modernatx, Inc. | Compositions and methods for cd28 antagonism |
WO2023218027A1 (en) | 2022-05-12 | 2023-11-16 | Amgen Research (Munich) Gmbh | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
WO2023223265A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for evaluating and treating psoriatic arthritis with il23 antibody |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2024006876A1 (en) | 2022-06-29 | 2024-01-04 | Abbott Laboratories | Magnetic point-of-care systems and assays for determining gfap in biological samples |
WO2024015953A1 (en) | 2022-07-15 | 2024-01-18 | Danisco Us Inc. | Methods for producing monoclonal antibodies |
WO2024039672A2 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against msln and methods of use thereof |
WO2024039670A1 (en) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Antibodies against cldn4 and methods of use thereof |
WO2024059675A2 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Bispecific molecule stabilizing composition |
WO2024059708A1 (en) | 2022-09-15 | 2024-03-21 | Abbott Laboratories | Biomarkers and methods for differentiating between mild and supermild traumatic brain injury |
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