WO1998029107A3 - Poly(diallylamine)-based bile acid sequestrants - Google Patents

Poly(diallylamine)-based bile acid sequestrants Download PDF

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Publication number
WO1998029107A3
WO1998029107A3 PCT/US1997/023899 US9723899W WO9829107A3 WO 1998029107 A3 WO1998029107 A3 WO 1998029107A3 US 9723899 W US9723899 W US 9723899W WO 9829107 A3 WO9829107 A3 WO 9829107A3
Authority
WO
WIPO (PCT)
Prior art keywords
diallylamine
poly
bile acid
acid sequestrants
patient
Prior art date
Application number
PCT/US1997/023899
Other languages
French (fr)
Other versions
WO1998029107A2 (en
Inventor
Stephen Randall Holmes-Farley
Pradeep K Dhal
John S Petersen
Original Assignee
Geltex Pharma Inc
Holmes Farley Stephen Randall
Pradeep K Dhal
John S Petersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geltex Pharma Inc, Holmes Farley Stephen Randall, Pradeep K Dhal, John S Petersen filed Critical Geltex Pharma Inc
Priority to EP97952646A priority Critical patent/EP1094801A2/en
Priority to JP53022198A priority patent/JP2002512598A/en
Priority to AU56210/98A priority patent/AU724507B2/en
Priority to CA002276394A priority patent/CA2276394A1/en
Priority to IL13064897A priority patent/IL130648A0/en
Priority to NZ336440A priority patent/NZ336440A/en
Publication of WO1998029107A2 publication Critical patent/WO1998029107A2/en
Priority to US09/286,341 priority patent/US6610283B1/en
Publication of WO1998029107A3 publication Critical patent/WO1998029107A3/en
Priority to US10/647,665 priority patent/US7125547B2/en
Priority to US11/498,309 priority patent/US20070190021A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule

Abstract

The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.
PCT/US1997/023899 1996-12-30 1997-12-29 Poly(diallylamine)-based bile acid sequestrants WO1998029107A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP97952646A EP1094801A2 (en) 1996-12-30 1997-12-29 Poly(diallylamine)-based bile acid sequestrants
JP53022198A JP2002512598A (en) 1996-12-30 1997-12-29 Bile acid sequestering agent based on poly (diallylamine)
AU56210/98A AU724507B2 (en) 1996-12-30 1997-12-29 Poly(diallylamine)-based bile acid sequestrants
CA002276394A CA2276394A1 (en) 1996-12-30 1997-12-29 Poly(diallylamine)-based bile acid sequestrants
IL13064897A IL130648A0 (en) 1996-12-30 1997-12-29 Poly (diallylamine)-based bile acid sequestrants
NZ336440A NZ336440A (en) 1996-12-30 1997-12-29 Poly(diallylamine) polymers useful as bile acid sequestrants
US09/286,341 US6610283B1 (en) 1996-12-30 1999-04-05 Poly(diallylamine)-based bile acid sequestrants
US10/647,665 US7125547B2 (en) 1996-12-30 2003-08-25 Poly(diallylamine)-based bile acid sequestrants
US11/498,309 US20070190021A1 (en) 1996-12-30 2006-08-01 Poly(diallylamine)-based bile acid sequestrants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/777,408 1996-12-30
US08/777,408 US6203785B1 (en) 1996-12-30 1996-12-30 Poly(diallylamine)-based bile acid sequestrants

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US08/777,408 Continuation-In-Part US6203785B1 (en) 1996-12-30 1996-12-30 Poly(diallylamine)-based bile acid sequestrants

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09/286,341 Continuation US6610283B1 (en) 1996-12-30 1999-04-05 Poly(diallylamine)-based bile acid sequestrants
US09/286,341 A-371-Of-International US6610283B1 (en) 1996-12-30 1999-04-05 Poly(diallylamine)-based bile acid sequestrants
US10/647,665 Continuation US7125547B2 (en) 1996-12-30 2003-08-25 Poly(diallylamine)-based bile acid sequestrants

Publications (2)

Publication Number Publication Date
WO1998029107A2 WO1998029107A2 (en) 1998-07-09
WO1998029107A3 true WO1998029107A3 (en) 2001-03-01

Family

ID=25110177

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023899 WO1998029107A2 (en) 1996-12-30 1997-12-29 Poly(diallylamine)-based bile acid sequestrants

Country Status (10)

Country Link
US (4) US6203785B1 (en)
EP (1) EP1094801A2 (en)
JP (1) JP2002512598A (en)
KR (1) KR20000069826A (en)
CN (1) CN1245425A (en)
AU (1) AU724507B2 (en)
CA (1) CA2276394A1 (en)
IL (1) IL130648A0 (en)
NZ (1) NZ336440A (en)
WO (1) WO1998029107A2 (en)

Cited By (4)

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US8889738B2 (en) 2006-12-14 2014-11-18 Genzyme Corporation Amido-amine polymer compositions
US8900560B2 (en) 2006-09-29 2014-12-02 Genzyme Corporation Amide dendrimer compositions
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
US9555056B2 (en) 2004-11-01 2017-01-31 Genzyme Corporation Aliphatic amine polymer salts for tableting

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US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US6203785B1 (en) * 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
GB9816171D0 (en) 1998-07-25 1998-09-23 Secr Defence Monomers and network polymers obtained therefrom
US6271264B1 (en) 1998-12-01 2001-08-07 Geltex Pharmaceuticals, Inc. Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
AU3990399A (en) * 1999-05-13 2000-12-05 Geltex Pharmaceuticals, Inc. Combination therapy for treating hypercholesterolemia
AU3988099A (en) * 1999-05-13 2000-12-05 Geltex Pharmaceuticals, Inc. Combination therapy for treating hypercholesterolemia
CA2379308A1 (en) * 1999-07-14 2001-01-25 Geltex Pharmaceuticals, Inc. Fat-binding polymers, optionally combined with lipase inhibitors
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
GB9927088D0 (en) * 1999-11-17 2000-01-12 Secr Defence Use of poly(diallylamine) polymers
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EP1923064B1 (en) 2001-04-18 2017-06-28 Genzyme Corporation Use of amine polymer for lowering serum glucose
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JP5170932B2 (en) * 2001-04-18 2013-03-27 ジェンザイム コーポレーション Polyallylamine in low salt form
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
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AU2003282867A1 (en) * 2002-10-22 2004-05-13 Genzyme Corporation Amine polymers for promoting bone formation
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
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JP5595660B2 (en) 2005-09-15 2014-09-24 ジェンザイム コーポレーション Sachet formulation for amine polymer
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CA2658338A1 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
JP2008102343A (en) * 2006-10-19 2008-05-01 Az Electronic Materials Kk Developed resist substrate processing liquid and method of processing resist substrate using the same
JP5000260B2 (en) * 2006-10-19 2012-08-15 ＡｚエレクトロニックマテリアルズＩｐ株式会社 Method for forming fine pattern and resist substrate processing liquid used therefor
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US20070190021A1 (en) 2007-08-16
CA2276394A1 (en) 1998-07-09
AU724507B2 (en) 2000-09-21
AU5621098A (en) 1998-07-31
WO1998029107A2 (en) 1998-07-09
US20040151687A1 (en) 2004-08-05
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US7125547B2 (en) 2006-10-24
KR20000069826A (en) 2000-11-25
US6203785B1 (en) 2001-03-20

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