WO1998029433A3 - Method for solubilization and naturation of somatotropins - Google Patents

Method for solubilization and naturation of somatotropins Download PDF

Info

Publication number
WO1998029433A3
WO1998029433A3 PCT/US1997/024287 US9724287W WO9829433A3 WO 1998029433 A3 WO1998029433 A3 WO 1998029433A3 US 9724287 W US9724287 W US 9724287W WO 9829433 A3 WO9829433 A3 WO 9829433A3
Authority
WO
WIPO (PCT)
Prior art keywords
somatotropin
naturation
solubilization
detergent composition
somatotropins
Prior art date
Application number
PCT/US1997/024287
Other languages
French (fr)
Other versions
WO1998029433A2 (en
Inventor
S Bradley Storrs
Jacob S Tou
Jessica Marie Ballinger
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Priority to CA002276252A priority Critical patent/CA2276252A1/en
Priority to KR10-1999-7005951A priority patent/KR100487299B1/en
Priority to AU69370/98A priority patent/AU6937098A/en
Priority to EP97955015A priority patent/EP0948540A2/en
Priority to JP53035698A priority patent/JP2001509793A/en
Publication of WO1998029433A2 publication Critical patent/WO1998029433A2/en
Publication of WO1998029433A3 publication Critical patent/WO1998029433A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)

Abstract

A method for the solubilization and/or naturation of a somatotropin involves contacting a somatotropin with a detergent composition and water under conditions effective to obtain a naturated somatotropin, wherein the detergent composition may be a C10, C12, C16 or C18 acyl glutamate, a C10, C14 or C18 alkyl sulfate, an alcohol ethoxy sulfate, lauroyl ethylenediamine-triacetic acid (LEDA), a C10 to C18 linear alkyl benzene sulfonate, diphenyl disulfonate or an acyl amino acid.
PCT/US1997/024287 1996-12-31 1997-12-31 Method for solubilization and naturation of somatotropins WO1998029433A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002276252A CA2276252A1 (en) 1996-12-31 1997-12-31 Method for solubilization and naturation of somatotropins
KR10-1999-7005951A KR100487299B1 (en) 1996-12-31 1997-12-31 Method for solubilization and naturation of somatotropins
AU69370/98A AU6937098A (en) 1996-12-31 1997-12-31 Method for solubilization and naturation of somatotropins
EP97955015A EP0948540A2 (en) 1996-12-31 1997-12-31 Method for solubilization and naturation of somatotropins
JP53035698A JP2001509793A (en) 1996-12-31 1997-12-31 Somatotropin solubilization and regeneration method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3480896P 1996-12-31 1996-12-31
US60/034,808 1996-12-31

Publications (2)

Publication Number Publication Date
WO1998029433A2 WO1998029433A2 (en) 1998-07-09
WO1998029433A3 true WO1998029433A3 (en) 1998-10-15

Family

ID=21878743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/024287 WO1998029433A2 (en) 1996-12-31 1997-12-31 Method for solubilization and naturation of somatotropins

Country Status (8)

Country Link
US (3) US6034224A (en)
EP (1) EP0948540A2 (en)
JP (1) JP2001509793A (en)
KR (1) KR100487299B1 (en)
AU (1) AU6937098A (en)
CA (1) CA2276252A1 (en)
WO (1) WO1998029433A2 (en)
ZA (1) ZA9711733B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711733B (en) * 1996-12-31 1998-07-01 Monsanto Co Method for solubilization and naturation of somatotropins
US6794159B1 (en) 1999-04-30 2004-09-21 Pharmacia Corporation Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
US6743600B1 (en) 1999-04-30 2004-06-01 Monsanto Technologies Llc Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
WO2009136568A1 (en) 2008-05-08 2009-11-12 味の素株式会社 Protein reforming method
BR102013026129A2 (en) * 2013-10-10 2016-05-24 Ouro Fino Participações E Empreendimentos S A process for the production of active recombinant bovine somatotropin and product obtained

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218374A1 (en) * 1985-09-06 1987-04-15 International Minerals And Chemical Corporation Purification and activation of proteins from insoluble inclusion bodies
EP0226448A2 (en) * 1985-12-11 1987-06-24 Fidelity Food Technologies Pty. Ltd. Solubilisation of protein aggregates
EP0295859A2 (en) * 1987-06-15 1988-12-21 Southern Cross Biotech Pty.Ltd. Production of proteins in active forms

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985722A (en) * 1973-12-12 1976-10-12 Ajinomoto Co., Inc. Process for preparing N-higher aliphatic acyl derivatives of amino acids, peptides or proteins
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
CA1224432A (en) * 1982-08-17 1987-07-21 Gary N. Buell Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield
US4518526A (en) * 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
ES8800957A1 (en) * 1985-02-22 1987-12-01 Monsanto Co Method of somatotropin solubilization and naturation.
GB8508340D0 (en) * 1985-03-29 1985-05-09 Creighton T E Production of protein
JPH06104070B2 (en) * 1985-06-26 1994-12-21 ジ・アップジョン・カンパニ− Purification of somatotropin from transformed microorganisms.
US4766224A (en) * 1985-08-19 1988-08-23 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4888416A (en) * 1987-03-30 1989-12-19 International Minerals & Chemical Corp. Method for stabilizing somatotropins
US4985544A (en) * 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
JPH01132598A (en) * 1987-10-14 1989-05-25 Pitman Moore Inc Method for promoting production of intramolecular disulfide bond in recominant protein contained in modifier solution
US4975529A (en) * 1989-08-18 1990-12-04 Monsanto Company Method of folding somatotropins
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
US5023323A (en) * 1990-09-12 1991-06-11 Monsanto Company Method of somatotropin naturation
US5240834A (en) * 1991-01-22 1993-08-31 Albert Einstein College Of Medicine Of Yeshiva University Solubilization of protein after bacterial expression using sarkosyl
SE9201073D0 (en) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab PROTEIN FORMULATION
DE69426570T2 (en) * 1993-11-03 2001-08-23 Isomed Inc MICELLOUS FINE-PARTIAL PHARMACEUTICAL COMPOSITIONS
DE69434626D1 (en) * 1993-11-17 2006-04-20 Athena Neurosciences Inc TRANSPARENT LIQUID FOR THE ADMINISTRATION OF CAPTIVATED MEDICAMENTS
ZA9711733B (en) * 1996-12-31 1998-07-01 Monsanto Co Method for solubilization and naturation of somatotropins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218374A1 (en) * 1985-09-06 1987-04-15 International Minerals And Chemical Corporation Purification and activation of proteins from insoluble inclusion bodies
EP0226448A2 (en) * 1985-12-11 1987-06-24 Fidelity Food Technologies Pty. Ltd. Solubilisation of protein aggregates
EP0295859A2 (en) * 1987-06-15 1988-12-21 Southern Cross Biotech Pty.Ltd. Production of proteins in active forms

Also Published As

Publication number Publication date
EP0948540A2 (en) 1999-10-13
WO1998029433A2 (en) 1998-07-09
US6562951B2 (en) 2003-05-13
KR20000069805A (en) 2000-11-25
CA2276252A1 (en) 1998-07-09
US6034224A (en) 2000-03-07
AU6937098A (en) 1998-07-31
KR100487299B1 (en) 2005-05-03
US20020058792A1 (en) 2002-05-16
JP2001509793A (en) 2001-07-24
ZA9711733B (en) 1998-07-01
US6410694B1 (en) 2002-06-25

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