WO1998030096A1 - Hydroalcoholic compositions thickened using surfactant/polymer complexes - Google Patents
Hydroalcoholic compositions thickened using surfactant/polymer complexes Download PDFInfo
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- WO1998030096A1 WO1998030096A1 PCT/US1997/023846 US9723846W WO9830096A1 WO 1998030096 A1 WO1998030096 A1 WO 1998030096A1 US 9723846 W US9723846 W US 9723846W WO 9830096 A1 WO9830096 A1 WO 9830096A1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
Definitions
- the present invention relates to compositions useful as surgical hand preparations and antimicrobial hand lotions. More specifically, the invention relates to stable hydroalcoholic compositions thickened using charged polymers and oppositely charged surfactants.
- Hand disinfection is generally accomplished using antimicrobial soaps with water.
- These soaps are usually formulated to include either povidone-iodine (usually 7.5% by weight) or chlorhexidine digluconate (CHG) (usually 2% or 4% by weight) as the active antimicrobial agent.
- these formulated soaps may contain surfactants and possibly low levels of humectants such as glycerin.
- Presurgical scrub replacements are used instead of the soap and water scrub.
- Presurgical scrub replacements ideally achieve bacterial kill equal to or better than a traditional soap and water scrub and in a shorter period of time. Additionally, they maintain or improve the skin's natural barrier to microbial and chemical contamination while providing acceptable tactile properties.
- Examples of presurgical scrub replacements include hydroalcoholic gels which generally include high levels of either ethanol or isopropanol as the disinfecting agent and also include a thickener and optionally a humectant (e.g., glycerin).
- thickeners used in hydroalcoholic gels have been based on anionic polymers such as polyacrylic acid (sold under the tradename "CARBOPOL” by BF Goodrich Specialty Polymers and Chemicals Division of Cleveland, Ohio).
- U.S. Patent No. 4,915,934 discloses the use of CHG-containing antiseptic foams based on hydroalcoholic solvents, a fatty alcohol, and a surfactant.
- the surfactant is selected from the group of ethoxylated sorbitan alkylates, ethoxylated fatty alcohols, and ethoxylated nonyl phenols. Formulating stable viscous hydroalcoholic emulsions is difficult for two reasons.
- U.S. Patent No. 4,956,170 discloses a hydroalcoholic skin moisturizing/conditioning antimicrobial gel.
- the gel comprises 60-75% by weight ethanol and 0.4-2% by weight of an anionic carbomer polymeric thickening agent.
- the formulations also comprise polyethoxylated nonionic surfactants/emulsifiers to stabilize the added emollient oils in addition to a fatty alcohol.
- 5,167,950 discloses an antimicrobial aerosol mousse having a high alcohol content.
- the mousse comprises alcohol, water, a polymeric gelling agent and a surfactant system comprising a C16-C22 alcohol, aerosol propellant, and a nonionic polyethoxylated surfactant.
- These systems are based on neutralized polymeric acrylic acids, which are anionic and therefore incompatible with positively charged molecules such as chlorhexidine digluconate.
- these systems while cosmetically acceptable, do not shear thin readily and can feel heavy with a somewhat tacky feel under gloves.
- nonionic, anionic, cationic, or zwitterionic emulsifiers are used as thickeners, without the need for a polymeric thickener such as polyacrylic acid.
- a polymeric thickener such as polyacrylic acid.
- the invention overcomes the shortcomings of past compositions by providing a viscous composition that can include a relatively high concentration of a lower alcohol, but does not require a high molecular weight polymeric thickener to make the composition viscous, which can often result in a slimy feeling once the hands are washed. Further, the composition has a cosmetically elegant feel and may be dispensed as a lotion or as a foam. It may also be suitable for the enhancement of the transdermal delivery of the pharmaceutical agent.
- One embodiment of the present invention is a hydroalcoholic composition
- a hydroalcoholic composition comprising: (a) a lower alcohol and water in a weight ratio of at least about 20:80; (b) a thickener system comprising a complex of at least one charged polymer and at least one oppositely charged surfactant, wherein the polymer and surfactant are selected such that: (i) the composition has a viscosity greater than that of the same composition with either the polymer or the surfactant absent; and (ii) the composition has a viscosity of at least about 4,000 centipoise at 23°C, when free of auxiliary thickeners.
- the composition is a stable hydroalcoholic composition.
- Another embodiment of the invention is a hydroalcoholic composition preparable by combining components comprising: (a) a lower alcohol and water in a weight ratio of at least about 20:80; (b) at least one ionizable polymer; and (c) at least one ionizable surfactant; wherein the polymer and surfactant are selected such that: (i) the hydroalcoholic composition has a viscosity greater than that of the same composition with either the polymer or the surfactant absent; and (ii) the hydroalcoholic composition has a viscosity of at least about 4,000 centipoise at 23°C, when free of auxiliary thickeners.
- the present invention also provides methods of preparing the hydroalcoholic compositions of the present invention.
- One method involves: heating an ionizable surfactant at a sufficient temperature to melt the surfactant; combining an ionizable polymer with a solvent system comprising water; combining the melted surfactant with the polymer/solvent system mixture to form a hydroalcoholic composition comprising a lower alcohol and water in a weight ratio of at least about 20:80; a thickener system comprising a complex of at least one charged polymer and at least one oppositely charged surfactant, wherein the polymer and surfactant are selected such that the composition has a viscosity greater than that of the same composition with either the polymer or the surfactant absent, and has a viscosity of at least about 4,000 centipoise at 23°C, when free of auxiliary thickeners.
- Ambient temperature refers to the temperature range of about 21-25°C.
- auxiliary thickeners refers to additives (other than the ionizable polymer and ionizable surfactants used to prepare the thickener system described below) which increase the viscosity of the solvent phase even in the absence of the thickener system. Certain auxiliary thickeners may act synergistically with the thickener system to increase the viscosity of the resultant formula. Auxiliary thickeners include but are not limited to soluble and swellable polymers and associative colloidal thickeners such as silica, magnesium aluminum silicate, and the like.
- Emollient refers broadly to materials which are capable of maintaining or improving the moisture level, compliance, or appearance of the skin when used repeatedly.
- Emulsifier refers to molecules comprising hydrophilic (polar) and hydrophobic (non-polar) regions on the same molecule capable of reducing the surface tension of water or the interglacial tension between an immiscible liquid or solid component and the solvent of the composition.
- Emulsion refers to a stable dispersion of one liquid in a second immiscible liquid. Emulsion also refers to stable dispersions of a solid in an immiscible liquid wherein the solid was formed by cooling below the freezing point of the solid composition.
- Ionizable Group refers to a group capable of forming an ion such as a primary, secondary, or tertiary amine, acids, and permanently charged groups such as those in quaternary amine salts.
- Ionizable Polymer refers to a natural, modified- natural, or synthetic molecule having repetitive units and having at least three ionizable groups per molecule.
- Ionizable Surfactant refers to molecules comprising hydrophilic (polar) and hydrophobic (non-polar) regions on the same molecule, and has at least one ionizable group per molecule.
- “Lotion” means liquid or cream, free of any propellant.
- Melt temperature T m as used herein refers to the temperature at which compositions or emulsions of the present invention dramatically lose viscosity.
- Periodically Charged refers to a group that remains charged independent of pH or hydrogen ion concentration, such as a quaternary amine.
- solvent solvent
- solvent system solvent system
- hydroalcoholic solvent hydroalcoholic solvent
- “Stable” as used herein refers to a composition that displays less than or equal to 10% by volume separation after centrifuging at 1545 x g for 30 minutes at ambient temperature.
- Thickener System refers to a complex of at least one charged polymer and at least one oppositely charged emulsifier.
- the invention provides a composition comprised of a lower chain alcohol, water, and a thickening system.
- the thickening system includes a complex of a charged polymer and an oppositely charged surfactant.
- This complex is formed as a result of reaction between ionizable groups on both the polymer and the surfactant to form ionic groups on both, which then ionically associate.
- this complex is formed as a result of acid-base reactions of the ionizable groups on the polymer and the surfactant.
- the polymer can have acidic or basic groups that, when combined with a surfactant having acidic or basic groups neutralize each other, thereby forming charged species. These charged species then ionically associate to form a complex that comprises the thickening system in the hydroalcoholic compositions of the present invention.
- the charged surfactant molecules can also hydrophobically associate as a result of the hydrophobic regions of the surfactant.
- the ionizable polymers and surfactants used to prepare the thickening system of the present invention may be capable of thickening (i.e., increasing the viscosity) a hydroalcoholic solvent system when used alone (i.e., just a polymer or mixture of polymers or just a surfactant or mixture of surfactants), there is significant improvement in the thickening of a hydroalcoholic solvent system (particularly at higher alcohol to water ratios) if the polymers and surfactants are chosen and combined such that they form a complex.
- compositions of the present invention include one or more alcohols in combination with water, thereby producing a hydroalcoholic solvent system.
- the alcohol used in the compositions of the present invention is a lower chain hydrocarbon alcohol (referred to herein as a "lower alcohol"), particularly a C1-C4 alcohol (i.e., an alcohol having 1-4 carbon atoms).
- the alcohol is ethanol, 2-propanol (i.e., isopropanol), or n-propanol.
- the alcohol is ethanol.
- Ethanol is a preferred alcohol because it provides quick killing of a broad spectrum of microbes. Furthermore, it has an acceptable odor to health practitioners and patients.
- compositions having an alcohol to water ratio within a range of about 40:60 to 95:5 by weight i.e., 40-95 weight percent alcohol and 5-60 weight percent water, based only on the weight of water plus lower alcohol in the composition
- the lower alcohol to water ratio is within a range of about 50:50 to about 85:15, more preferably about 60:40 to about 75:25.
- Higher ratios of alcohol to water are used in preferred embodiments for optimum antimicrobial activity and to ensure the composition is fast drying.
- the thickener system useful in this invention affects the cosmetic attributes of the final composition.
- hand preps and lotions of the invention have the following desirable cosmetic attributes.
- the composition should not result in excessive clumping of glove powder beneath powdered surgical gloves and should not affect the integrity of the glove material.
- the compositions should preferably maintain an acceptable viscosity (e.g., at least about 4000 centipoise) at ambient temperatures (i.e., 21-25°C), and preferably up to about 35°C.
- Preferred compositions are stable to heat and cool cycles (heating up to 50°C or higher and cooling to ambient temperature) as well as freeze/thaw cycles (cooling to -30°C and warming to ambient temperature). All of these cosmetic attributes are affected by the types and amounts of polymers and surfactants chosen, which combine to form a complex that comprises the thickener system of the present invention.
- compositions of this invention have a viscosity of at least about 4,000 centipoise (cps), preferably at least about 10,000 cps, more preferably at least about 20,000 cps, even more preferably at least about 50,000 cps, and most preferably at least about 80,000 cps (and even as high as about 500,000 cps or more), at 23 °C, measured using a very low shear viscometer such as Brookfield LVDV-I+ viscometer and T spindles with a heliopath adapter.
- cps centipoise
- the measured viscosity is that of the final composition, with all of these additional components but without any added auxiliary thickeners (e.g., noncomplexed polymeric thickeners or colloidal thickeners).
- a "complex” refers to the association of ionic polymer and surfactant molecules formed upon ionization of their respective ionizable molecules.
- Such ionizable molecules may be in the form of acids, bases, or salts, including salts of permanently charged species.
- the ionizable polymer used to prepare the thickener system is comprised of ionizable groups (at least three per molecule), which may be basic, acidic, anionic, or permanently charged.
- the ionizable surfactant used to prepare the thickener system is comprised of ionizable groups (at least one per molecule), which may be basic, acidic, anionic, or permanently charged.
- the thickener system so formed is comprised of a polymeric species ionically bound to a surfactant species of opposite charge, which is preferably present in an amount sufficient to ionically associate with at least about 3 mole-% of the ionic groups on the polymer molecules.
- the polymer Once reacted with the surfactant in the thickener system, the polymer possesses the opposite charge of the surfactant and is thus complexed with the surfactant.
- the polymer/surfactant complex may be formed by combining acids and bases. Alternatively, it may be formed by combining salts of opposite charge.
- the polymer For surfactants that are acidic in nature (and thus carry a negative charge once neutralized by the polymer), the polymer should be basic, and therefore is comprised of groups that contain basic functionality.
- the polymer For surfactants that are basic in nature (and thus carry a positive charge once neutralized by the polymer) the polymer should be acidic, and therefore is comprised of groups that contain acidic functionality.
- basic groups include primary, secondary, or tertiary amines, which upon neutralization form protonated amino groups.
- acidic groups, which upon neutralization form anionic groups include hydrogen sulfate (-OSO 2 OH), sulfonic acid (-SO 2 OH), hydrogen phosphate ((-O) 2 P(O)OH or
- M is a positively charged counterion and is selected from the group consisting of hydrogen, sodium, potassium, lithium, ammonium, calcium, magnesium or N R' where each R' is independently an alkyl group of 1 to 4 carbon atoms optionally substituted with N, O, or S atoms.
- the ionizable polymer used to prepare the thickener system in the compositions of the present invention may be a homopolymer or a copolymer and may be of natural, modified natural, or synthetic origin.
- preferred ionizable polymers are of low enough molecular weight that a hydroalcoholic solvent system in a ratio of 40:60 alcohol to water, containing an ionizable polymer in an amount of 4% by weight, has a viscosity of less than about 50,000 centipoise (cps), preferably less than about 30,000 cps, more preferably less than about 15,000 cps, and most preferably less than about 4000 cps.
- cps centipoise
- a slimy feel is usually imparted by higher molecular weight polymers, such as polyethylene oxide, that impart not only a high viscosity to the composition but create a highly viscoelastic composition as well.
- the viscous compositions of this invention are believed to derive their thickening efficiency from a hydrophobic association of the surfactants which are, in turn, ionically associated with the polymeric chains.
- These Van der Waals and/or ionic associations are generally easily disrupted making the lotions shear-sensitive and therefore easy to apply because the shear used during application decreases the viscosity significantly. It will be understood by one of skill in the art, however, that a certain amount of viscoelasticity and/or high yield stress may be highly desirable toward imparting stability to the compositions of the present invention.
- the ionizable polymer used to prepare the thickener systems of the present invention are preferably basic or acidic.
- Suitable basic polymers include groups that are primary, secondary, or tertiary amines, or combinations thereof.
- suitable polymers with basic functionality include, but are not limited to, polymers based on unsaturated monomers wherein at least one monomer is an unsaturated primary, secondary, or tertiary amine such as polyacrylates based on dialkylaminoalkylacrylate (e.g., dimethylaminoethylacrylate), dialkylaminoalkylmethacrylate (e.g., dimethylaminoethylacrylate), alkyldiallylamine (e.g., methyldiallylamine), dialkylaminoalkylacrylamide (e.g., dimethylaminopropylacrylamide), dialkylaminoalkylmethacrylamide (e.g., dimethylaminopropylmethacrylamide).
- suitable polymers with basic functionality include polymers prepared by reaction of suitable reagents that leave free primary, secondary, or tertiary amine groups (e.g., polyvinylalcohol reacted with 2,3-epoxypropylamine), polymers based on aziridine such as aziridine modified polymers as well as polyethyleneimine, and natural polymers such as amino functional polysaccharides (e.g., chitosan and modified chitosan), and aminofunctional proteins and polypeptides (e.g., polylysine). Combinations of these polymers can also be used.
- suitable reagents that leave free primary, secondary, or tertiary amine groups
- aziridine such as aziridine modified polymers as well as polyethyleneimine
- natural polymers such as amino functional polysaccharides (e.g., chitosan and modified chitosan), and aminofunctional proteins and polypeptides (e.g., polylysine). Combinations of these polymers can also be
- Suitable acidic polymers include acidic functionality such as hydrogen sulfate, sulfonic acid, hydrogen phosphate, phosphonic acid, and carboxylic acid, as listed above.
- suitable polymers with acidic functionality include, but are not limited to, polymers based on unsaturated monomers wherein at least one monomer is an unsaturated acid.
- suitable unsaturated acids include acrylic acid, methacrylic acid, vinyl phosphonic acid, vinyl sulfonic acid, and 2-methyl-2-(l-oxo-2-propenyl)amino-l -propane sulfonic acid (homopolymer is commercially available from Henkel Corp. as
- HSP-1180 Other polymers containing free acid groups are also suitable such as "PECOSIL PS- 100” polymer available from Phoenix Chemical Inc., Somerville, New Jersey, which is a dimethicone copolyol phosphate, as well as “GANTREZ” ES, SP, and V series polymers available from ISP, Wayne, New Jersey, which are monoalkyl esters of poly(methyl vinyl ether/maleic acid).
- the ionizable polymers used to prepare the thickener system may also include hydrophobic side chains that are capable of hydrophobically associating with the ionizable surfactant and/or other hydrophobic side chains of other polymer molecules.
- suitable hydrophobic side chains include alkyl side chains having at least 16 carbon atoms, preferably at least 18 carbon atoms, and more preferably at least 20 carbon atoms, polystyrene side chains (typically of about 2,000 to 30,000 number average molecular weight), and the like, and mixtures thereof.
- Suitable surfactants for use in the present invention are comprised of molecules having hydrophilic (polar) and hydrophobic (non-polar) regions on the same molecule and conform to the general structure:
- R represents a hydrophobic group
- L represents a hydrophilic group having at least one ionizable group when the surfactant is ionizable (i.e., prior to reaction with the polymer) or at least one ionic group when the surfactant is charged (i.e., as a result of reaction with the polymer), and "a” and “b” are independently 1 to 4.
- These compounds have at least one ionizable group, which may be acidic, basic, anionic or permanently charged.
- R includes an alkyl group of at least 16 carbon atoms, preferably at least 18 carbon atoms, more preferably at least 20 carbon atoms, and most preferably at least 22 carbon atoms; an alkenyl group of at least 16 carbon atoms, preferably at least 18 carbon atoms, and more preferably 20 carbon atoms; or an aralkyl or aralkenyl group of at least 20 carbon atoms, preferably at least 24 carbon atoms, and more preferably at least 26 carbon atoms.
- "R” is unbranched. These hydrophobic groups allow for hydrophobic association of the surfactant molecules.
- L represents a basic group including a primary amine, a secondary amine, or a tertiary amine; an acidic group (protonic acid) including hydrogen sulfate (-OSO OH), sulfonic acid (-SO OH), hydrogen phosphate ((-O).P(O)OH or -OP(O)(OH) 2 or -OP(O)(OH)O M + ), phosphonic acid (-PO(OH) 2 or -PO(OH)O " M + ), and carboxylic acid (-CO H), wherein, M is a positively charged counterion and is selected from the group consisting of hydrogen, sodium, potassium, lithium, ammonium, calcium, magnesium or N R' where each R' is independently an alkyl group of 1 to 4 carbon atoms optionally substituted with N, O, or S atoms; an anionic group derived from an acidic group or salt of an acidic group; or a permanently charged group such as a quaternary
- the surfactant may have more than one acidic, basic, anionic, or permanently charged hydrophilic group. It may also have additional nonionic groups, such as amide, ester, alcohol, sorbitan, polyglyceryl (generally having 2 to 10 or more glyceryl units), polyglucoside (generally having 1 to 10 or more glucoside units), polyethylene glycol (generally having 1 to 100, preferably 5 to 50 polyethylene oxide units), or combinations thereof.
- additional nonionic groups such as amide, ester, alcohol, sorbitan, polyglyceryl (generally having 2 to 10 or more glyceryl units), polyglucoside (generally having 1 to 10 or more glucoside units), polyethylene glycol (generally having 1 to 100, preferably 5 to 50 polyethylene oxide units), or combinations thereof.
- the surfactant is typically used in an amount effective to complex with (for example, by neutralization) at least about 3 mole-% of the ionizable polymer groups.
- the surfactant is used in an amount effective to complex with (for example, by neutralization) at least about 5 mole-%, more preferably at least about 10 mole-%, most preferably at least about 20 mole-%, and even as high as 100 mole-% or more (e.g., 200 mole-%), of the ionizable polymer groups.
- the surfactant is present in its charged form in the thickener system in an amount sufficient to ionically associate with at least about 3 mole-% (preferably at least about 5 mole-%, more preferably at least about 10 mole-%, most preferably at least about 20 mole-%, etc.) of the ionic groups on the polymer molecules. In certain systems, excess surfactant (on a molar basis) may be desirable.
- the thickener system can be prepared from one or more ionizable polymers and one or more ionizable surfactants. Each of these may be chosen from a single class of compounds or from more than one class.
- more than one surfactant is used, it is preferably present in a concentration of at least about 0.05% by weight, and more preferably at least 0.1% by weight, based on the total weight of the composition.
- Thickener systems of the present invention are capable of achieving high viscosities at relatively low total surfactant concentrations.
- the total concentration of surfactants present in the thickener system is generally less than about 8% by weight, preferably less than about 5% by weight, more preferably less than 4% by weight, and most preferably less than 3% by weight of the total composition of the present invention.
- a surfactant is considered part of the thickener system if it is charged, has an opposite charge to that of the charged polymer, is capable of associating with the charged polymer, and its presence in the composition results in an increase in the viscosity of the composition.
- Certain surfactants or emulsifiers that do not have these characteristics may also be present in the composition and may actually increase the viscosity of the composition, but for purposes of this invention, they are not considered part of the thickener system.
- a certain surfactant does not result in increasing the viscosity of the composition, it is considered an emollient or stabilizer, for example, which are defined below.
- At least one of the surfactants is a solid at ambient temperature.
- Such solid surfactants typically include at least one long chain hydrocarbon of at least 16 carbon atoms, preferably at least 18 carbon atoms, and more preferably at least 22 carbon atoms.
- the long chain hydrocarbon group preferably has at least 18 carbon atoms. The longer hydrocarbon chain length is believed to reduce the irritation potential of the compositions.
- the ionizable polymers and surfactants are selected such that the composition, free of auxiliary thickeners, has a viscosity of at least about 4,000 centipoise at 23°C.
- the ionizable polymers and surfactants are selected such that the composition has a viscosity that is greater than the same composition without either the ionizable polymer or the ionizable surfactant. That is, each of the polymer and the surfactant alone may be capable of increasing the viscosity of the composition. However, when used together, the complex of the charged polymer and charged surfactant is capable of increasing the viscosity of the composition to a much greater extent than either the ionizable polymer or the ionizable surfactant alone.
- the amount of ionizable polymer in the thickener system is preferably less than about 12% by weight, more preferably less than about 8% by weight, and most preferably less than about 4% by weight of the total composition of the present invention.
- the amount of the thickener system i.e., polymer/surfactant complex
- Preferred compositions of the present invention which are substantially free of auxiliary polymeric thickening agents, have a "melt temperature" (T m ).
- Thickener systems affect the melt temperature of a given composition.
- the thickener system in order to obtain a melt temperature in excess of about 25°C (and preferably, about 35°C), the thickener system includes at least one surfactant which is solid (e.g., a wax) at ambient temperature.
- the surfactants of the thickener system are solid at ambient temperature to increase the melt temperature of the resultant composition.
- the structure of surfactants in a thickener system affects the melt temperature of the resultant composition.
- at least one surfactant in a thickener system is capable of promoting a crystalline structure. Crystallinity is promoted by long straight chain alkyl groups. Therefore, at least one surfactant preferably comprises a saturated straight chain hydrocarbon of at least 16, preferably at least 18, and more preferably at least 20 carbon atoms.
- the surfactant chain length also helps to determine the maximum level of lower alcohol that can be used in the composition while maintaining a viscous composition (if so desired) and the concentration of surfactants required in the thickener system. For example, at higher levels of lower alcohol, longer chain surfactants are desired to produce stable viscous emulsions. It is believed that higher levels of lower alcohol tend to swell or solubilize the surfactants to a greater degree than lower levels of the same alcohol. Therefore, as the concentration of the lower alcohol increases, the chain length of the hydrocarbon group in the surfactants of the thickener system also increases in order to maintain a melt temperature over 25°C (preferably, over 35°C). In addition, as the chain length of the hydrophobic component in the thickener system increases, the amount of surfactant required to achieve a certain viscosity decreases.
- Preferred thickener systems used in the compositions of the present invention are capable of producing viscoelastic compositions that are preferably very stable.
- the degree of elasticity can be adjusted from almost a purely viscous composition to a highly elastic and even gel-like composition. If emollients are added, increasing the elasticity of the system imparts added stability to prevent separation of immiscible emollients. Excessive elasticity, however, is not preferred because an elastic composition usually does not provide a cosmetically appealing product. Addition of certain surfactants with at least two hydrophobic groups may limit the viscoelasticity while ensuring viscous stable compositions.
- a favored class of surfactants having multiple hydrophobic groups are tertiary amines conforming substantially to the following structure: R'
- Suitable multiple hydrophobic surfactants which may be added in addition include dialkylglycerol esters, trialkylglycerol esters, polyglycerol alkyl esters, ethylene glycol dialkylesters, polyethylene glycol dialkylesters, dialkylamides of diamines such as ethylene diamine, polyalkylesters of pentaerythritol, and alkyl esters of polyethyoxylated alkyl alcohols.
- surfactant classes are offered as nonlimiting examples of suitable surfactants for use in the present invention. Examples of some preferred surfactants are provided for each class.
- R 4 is a straight chain alkyl or alkenyl group of at least 14 carbon atoms, preferably at least 16 carbon atoms, more preferably at least 18 carbon atoms, and most preferably at least 20 carbon atoms, optionally substituted by N, O, and S atoms, or an aralkyl or aralkenyl group of at least 16 carbon atoms, preferably at least 18 carbon atoms, and more preferably at least 22 carbon atoms, optionally substituted by N, O, and S atoms.
- R 4 may also be selected from polyethoxylated or polypropoxylated alkyl or alkenyl alcohol chains having 1-50 moles of ethylene oxide or propylene oxide groups per mole of surfactant.
- R 5 is a short chain alkyl group of 1 to 4 carbon atoms, preferably methyl, ethyl, or propyl; and R 6 is the same as R 4 or R 5 .
- R 6 is an alkyl, alkenyl, or aralkyl group of at least 14 carbon atoms, preferably at least 16 carbon atoms, more preferably at least 18 carbon atoms, and most preferably at least 20 carbon atoms, optionally comprising oxygen, nitrogen, or sulfur atoms within or substituted upon the alkyl or alkenyl chain; or a polyethoxylated and/or polypropoxylated alkyl, alkenyl group, or aralkyl group, which alkyl, alkenyl, or aralkyl group comprises at least 14 carbon atoms, preferably at least 16 carbon atoms, more preferably at least 18 carbon atoms, and most preferably at least 20 carbon atoms, optionally comprising oxygen, nitrogen, or sulfur atoms within or substituted upon the alkyl, alkenyl, or aralkyl chain.
- R 6 is a polyethoxylated or polypropoxylated substituent or a copolymeric substituent of ethylene oxide and propylene oxide, these subunits are present in amounts of 1 to 100 moles, preferably 1 to 20 moles per mole of hydrophobe;
- L is sulfate (-OSO O " ), sulfonate
- M is hydrogen (H + ), sodium (Na + ), potassium (K + ), lithium (Li + ),
- suitable for use in a thickener system of the invention include behenic acid available as "CROACID B” from Croda, Inc. and stearyl phosphate available as "SIPPOSTAT 0018" from Specialty Industrial Products, Inc. of Spartanburg, SC.
- R 9 wherein R 10 is a straight chain alkyl or alkenyl group of at least 12 carbon atoms, preferably at least 16 carbon atoms, more preferably at least 18 carbon atoms, and most preferably at least 20 carbon atoms, or an aralkyl or aralkenyl group of at least 14 carbon atoms, preferably at least 18 carbon atoms, and more preferably at least 22 carbon atoms;
- R 7 is a short chain alkyl group of 1 to 4 carbon atoms, preferably methyl or ethyl;
- R 8 is the same as R 7 , or is a long chain alkyl or alkenyl hydrocarbon chain of at least 12 carbon atoms, preferably at least 16 carbon atoms, more preferably at least 18 carbon atoms, and most preferably at least 20 carbon atoms, optionally substituted in available positions by N, O, or S atoms, or R 8 is an aralkyl or aralkenyl group of at least 14 carbon
- R"CO -, (R") PO ", or (R M )PO (wherein R 11 is a short chain alkyl group of 1 to 4 carbon atoms, preferably methyl or ethyl).
- Nonlimiting examples of quaternary amine surfactants include dibehenyldimethylammonium methosulfate available as "INCROQUAT DBM-90" from Croda; behenyltrimethylammonium chloride available as “NIKKOL CA- 2580” from Barnet Products; and tallowtrimethylammonium chloride available as "ARQUAD T-27W” from Akzo Chemicals, Inc. of Chicago, Illinois.
- Surfactants other than those required in the composition to provide a thickener system may also function as emollients or stabilizers.
- certain emollients are also comprised of hydrophobic and hydrophilic regions and are useful in the present invention since they are believed to associate with the surfactant of the thickener system. These emollients tend to affect the stability of the composition.
- certain dimethicone copolyol surfactants can actually improve the stability of formulations incorporating emollients.
- compositions of the present invention may optionally include ingredients such as salts, emollients, stabilizers, antimicrobials, fragrances, pharmaceutical agents, penatrant enhancers, propellants, and emulsifiers.
- ingredients such as salts, emollients, stabilizers, antimicrobials, fragrances, pharmaceutical agents, penatrant enhancers, propellants, and emulsifiers.
- the melt temperature and stability of the compositions of the present invention may be affected by adding salts. As the concentration of salt is increased, the ratio of surfactant to polymer may need to change in order to maintain a stable composition. It is important to choose salts which do not create an unstable system and are compatible with any antimicrobials or pharmaceutical agents present in the system. For example, chlorhexidine digluconate (CHG) will precipitate rapidly in the presence of halide salts above a concentration of about 0.1M. Therefore, if a system includes CHG, preferably gluconate salts such as triethanolamine gluconate or sodium gluconate, are used.
- CHG chlorhexidine digluconate
- pH buffers may also be beneficial to incorporate pH buffers to maintain the desired pH during storage and use, thereby providing long term stability.
- the choice of the preferred pH buffer would depend on the thickener system. Suitable buffers are those that do not interfere with the complexation of the polymer/surfactant complex.
- a stable composition is one which does not separate more than 10% by volume after centrifuging at 1545 x g for 30 minutes as measured at the longitudinal midpoint of the sample tube. It is also recognized that stability may be time dependent due to precipitation of the polymer/surfactant complex, crystallization of emulsifiers and/or emollients present in the system, coalescence of emollients, emulsifiers and the like. Therefore, preferred compositions do not exhibit separation of more than 10% after standing for 6 months at ambient conditions.
- Two types of stabilizers are useful in the present invention. These include (1) those stabilizers that complex with emulsifier or surfactant hydrophilic head groups, and (2) those that associate with the emulsifier or surfactant hydrophobic tails.
- Certain stabilizers may perform both functions.
- polymers, surfactants or emulsifiers comprising 1 ,2-diol-containing head groups such as alkylpolyglucosides, monoalkylglycerides, and polyglycerol alkyl esters, may be "stabilized” by adding borate ion.
- borate ions complex with adjacent head groups which may increase the association of hydrophobic tails by holding them in close proximity.
- Natural, modified-natural, or synthetic polymers comprised of pendent long chain alkyl groups (greater than 12 and preferably greater than 16 carbon atoms) such as stearyl modified cellulose derivatives, stearyl modified proteins such as wheat protein, stearyl modified collagen, polymers comprising stearyl methacrylate, and the like, are capable of stabilizing compositions of the present invention. Such added components may also increase the melt temperature of compositions of the present invention. It is believed that the pendent alkyl groups in these polymers associate by Van der Waals interactions with the hydrophobes of a thickening system, thereby enhancing the stability of the crystalline structure.
- Polymeric thickeners which do not have associative pendent alkyl chains may also increase the melt temperature presumably by increasing the viscosity of the continuous phase.
- a nonlimiting example of such thickeners are quaternary celluloses such as "CELQUAT 230M” available from National Starch of Bridgewater, New Jersey.
- stearyldimonium hydroxypropyl cellulose commercially available as "CRODACEL QS” from Croda Inc., Parsippany, NJ is added as a stabilizer.
- Emollients are typically added to hand lotions or hand preps because they act to increase the moisture content of the stratum corneum. Emollients are generally separated into two broad classes based on their function. The first class of emollients function by forming an occlusive barrier to prevent water evaporation from the stratum corneum. The second class of emollients penetrate into the stratum corneum and physically bind water to prevent evaporation. The first class of emollients is subdivided into compounds that are waxes at room temperature and compounds which are liquid oils. The second class of emollients includes those that are water soluble and are often referred to as humectants.
- the thickener system is considered separate and distinct from any emollients which may be added even though it is recognized that the surfactant may function as an occlusive emollient and aid in maintaining or improving the skin condition. It is also recognized that the polymer/surfactant system may function to improve skin condition either as an occlusive complex, or by binding water, or both. If emollients are included, they preferably comprise about 0.5% to about 30%, more preferably about 2% to about 20%, and most preferably about 4% to about 16%, by weight of the formulation.
- the ratio of wax to liquid emollients (oils and humectants) in a preferred embodiment of the invention is within a range of about 5:1 to about 1:5 and preferably about 1 :3 to about 3:1.
- Emollients may be selected from any of the classes known in the art. A general list of useful emollients appears in U.S. Patent No. 4,478,853 (Cbrie), EPO Patent Publication No. 0 522 624 Al (Dunphy et al.) and in the CTFA Cosmetic Ingredient Handbook published by The Cosmetic, Toiletry, and Fragrance Association, Wash. D.C. (1992) under the listings "Skin Conditioning agents,” “emollients,” “humectants,” “miscellaneous,” and “occlusive.”
- emollients are chosen from the following nonlimiting list of general emollients, occlusive emollients and humectants.
- general emollients include short chain alkyl or aryl esters (C1-C6) of long chain straight or branched chain alkyl or alkenyl alcohols or acids (C8-C36) and their polyethoxylated derivatives; short chain alkyl or aryl esters (C1-C6) of C4-C12 diacids or diols optionally substituted in available positions by -OH; alkyl or aryl C1-C9 esters of glycerol, pentaerythritol, ethylene glycol, propylene glycol, as well as polyethoxylated derivatives of these and polyethylene glycol; C12-C22 alkyl esters or ethers of polypropylene glycol; C12-C22 alkyl esters or ethers of poly
- occlusive emollients include cyclic dimethicones, polydialkylsiloxanes, polyaryl/alkylsiloxanes, long chain (C8-C36) alkyl and alkenyl esters of long straight or branched chain alkyl or alkenyl alcohols or acids; long chain (C8-C36) alkyl and alkenyl amides of long straight or branched chain (C8-C36) alkyl or alkenyl amines or acids; hydrocarbons including straight and branched chain alkanes and alkenes such as squalene, squalane, and mineral oil; polysiloxane polyalkylene copolymers, dialkoxy dimethyl polysiloxanes, short chain alkyl or aryl esters (C1-C6) of C12-C22 diacids or diols optionally substituted in available positions by OH; and C12-C22 alkyl and alkenyl
- Nonlimiting examples of preferred humectant type emollients include glycerol, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, pantothenol, gluconic acid salts and the like.
- emollients may also affect the viscosity, stability, and melt temperature of a composition. It is anticipated that a single emollient may be added to the present invention or two or more emollients may be added to the composition. A wide range of emollients may be added to the formulations of the present invention. Preferably wax and oil type emollients along with water soluble emollients are used.
- emollient systems are comprised of humectants in addition to occlusive wax and oil emollients in concentrations which achieve a moisturizing but not greasy composition which maintains and improves the condition of the skin upon repeated use.
- emollients are non-comedogenic and are chosen to ensure no skin irritation or sensitization reaction occurs. This is particularly critical since the composition of the present invention will likely be worn in an occluded condition under surgical gloves.
- emollients should be chosen which do not affect the integrity of the glove material. For example, since hydrocarbon emollients such as mineral oil and petrolatum can detrimentally affect the tear strength of surgical gloves, these emollients may need to be avoided for compositions employed as presurgical disinfectants.
- emollients are added to the present compositions, they may be present in four distinct regions.
- the emollients could occur (1) as a soluble species in the solvent phase, (2) dispersed as emulsified droplets within the composition, (3) incorporated into an emulsifier micelle or network if present, or (4) as a separate and distinct emulsion.
- emollients can affect the melt temperature of a composition. Those emollients that are soluble or dispersible in the solvent phase tend to have little or no affect on the melt temperature and are therefore preferred.
- These emollients include the humectant and general emollients.
- the most preferred general emollients are those which are essentially insoluble in water but soluble in the hydroalcoholic solvent. These emollients are also preferred since they remain soluble and uniformly dispersed even above the melt temperature so that upon cooling to room temperature a uniform composition results. In addition, they are also believed to have little effect on surgical gloves. Such general emollients typically do not have alkyl or alkenyl chains greater than about 14, preferably not greater than 12 and most preferably not greater than about 9 carbon atoms.
- emollients that are insoluble in the hydroalcoholic solvent may associate with the surfactants of the thickener system and/or additional emulsifiers and may become incorporated into the micelle or crystalline gel network if present.
- Preferred emollients within this class are those emollients that are very hydrophobic since they tend to maintain a high melt temperature.
- Those emollients which are capable of associating with and disrupting the emulsifiers of the thickener system tend to decrease the melt temperature and may influence the stability of the composition.
- emulsifier/emollient components which improve thickening/stability of compositions of the present invention.
- Certain wax emulsifiers/emollients have been found to be particularly useful and include solid waxy esters such as: Myristyl Myristate, Cetyl Palmitate, Myristyl Stearate, Stearyl Behenate, Behenyl Isostearate, Isostearyl Behenate, Behenyl Behenate, Lauryl Behenate, Behenyl Erucate.
- Petrolatums which are mixtures of oily and waxy long chain hydrocarbons, provide excellent emolliency, and can also improve the stability of the emulsion when used in combination with oil emollients.
- antimicrobials i.e., a secondary antimicrobial agent
- a secondary antimicrobial agent may be added to enhance the antimicrobial action of the compositions of the present invention. This may be particularly desirable in critical uses such as presurgical hand scrubs.
- Suitable additional antimicrobials include iodine and its complexed forms such as povidone/iodine, chlorhexidine salts such as chlorhexidine digluconate (CHG), parachlorometaxylenol (PCMX), hexachlorophene, phenols, surfactants comprising a long chain hydrophobe (C12-C22) and a quaternary group, triclosan, "LAURICIDIN” glyceryl monolaurate, quaternary silanes, hydrogen peroxide, phenols, silver, silver salts such as silver chloride, silver oxide and silver sulfadiazine and the like.
- the antimicrobial level should be adjusted to the minimum level which maintains a low bacteriological count for 6 and most preferably for 12 hours after application.
- chlorhexidine-containing thickener system are preferably based on non- precipitating surfactants and polymers. These include certain alkyl phosphate and alkyl sarcosinate surfactants in combination with aminofunctional polymers. In addition, certain zwitterionic and cationic non-precipitating surfactants may also be useful. Propellants
- compositions of the present invention may also be formulated into an aerosol foam or mousse by addition of an appropriate propellant.
- the propellant must be chosen to ensure proper delivery from the container to prevent clogging of the valve.
- the propellant can be chosen from chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), hydrofiuorocarbons (HFCs), perfiuorinated alkanes, and lower alkanes (C1-C5) as well as nitrous oxide, dimethyl ether, and other solvent-soluble propellants.
- Preferred propellants are lower alkanes such as propane, butane, and isobutane since these result in a dramatic loss in viscosity making the formulation easy to dispense.
- a 70:30 mixture of propane/isobutane is a particularly preferred embodiment.
- the antimicrobial lotion is first formulated and charged into an appropriate pressure rated container. If convenient, the formulation may be heated above the melt temperature in order to facilitate filling. The propellant is then added under pressure at approximately 2-30% preferably 3- 20% by volume. The propellant may form a separate layer or may remain emulsified in the composition.
- Suitable pharmaceutical agents include antiinflammatory drugs, both steroidal (e.g., hydrocortisone, prednisolone, triamcinolone) and nonsteroidal (e.g., naproxen, piroxicam); antibacterials (e.g., penicillins such as penicillin V, cephalosporins such as cephalexin, erythromycin, tetracycline, gentamycin, sulfathiazole, nitrofurantoin, and quinolones such as norfloxacin, flumequine, and ibafloxacin); antiprotazoals (e.g., metronidazole); antifungals (e.g.
- vasodilators e.g., nitroglycerin
- calcium channel blockers e.g., nifedipine, diltiazem
- bronchodilators e.g., theophylline, pirbuterol, salmeterol, isoproterenol
- enzyme inhibitors such as collagenase inhibitors, protease inhibitors, elastase inhibitors, lipoxygenase inhibitors (e.g., A64077), and angiotensin converting enzyme inhibitors (e.g., captopril, lisinopril); other antihypertensives (e.g., propranolol); leukotriene antagonists (e.g., 10204,219) antiulceratives such as H2 antagonists; steroidal hormones (e.g., progesterone, testosterone, estradiol, levonorgestrel); antivirals and/or immunomodulators (e
- Additional compounds other than the lower alcohol or components of the emulsifier system may also be present in the composition to further boost the penetration of a particular pharmaceutical agent.
- These penetration enhancers may be present primarily in either the oil-like phase of the emulsion or the hydroalcoholic phase.
- Certain emulsifier systems may also significantly increase the flux of particular pharmaceutical agents. This may be particularly true of emulsifiers that are in a pure state liquids at skin temperature such as those having shorter chain hydrophobes (e.g., methyl laurate), unsaturated hydrophobes (methyl oleate, oleic acid, oleyl alcohol, glycerol monooleate), and branched hydrophobic hydrocarbon chains (isostearyl alcohol).
- shorter chain hydrophobes e.g., methyl laurate
- unsaturated hydrophobes methyl oleate, oleic acid, oleyl alcohol, glycerol monooleate
- branched hydrophobic hydrocarbon chains isostearyl alcohol.
- compositions of the present invention can be used in a variety of transdermal delivery systems (e.g., devices).
- transdermal delivery systems e.g., devices
- the simplest is a lotion of a pharmaceutical agent in the composition of the present invention.
- Others include matrix devices in which a pharmaceutical agent is incorporated into the composition of the present invention and placed within a polymeric material such as a hydrogel layer or adhesive; reservoir devices in which the pharmaceutical agent-containing hydroalcoholic composition is delivered to the skin through a rate-controlling membrane; drug-inadhesive devices in which the pharmaceutical agent is placed within the composition of the present invention as part of an adhesive composition; and more complex multilaminate devices involving several distinct layers (e.g., layers for containing the pharmaceutical agent, for containing excipients, for controlling the rate of release of the pharmaceutical agent and excipients, and for attaching the device to the skin).
- Each of these devices include an adhesive to maintain contact with the patient's skin and a backing that protects the device from external factors while in use,
- compositions of this invention may be compounded with UV absorbers and oils to deliver fast-drying sunscreens.
- Antimicrobials such as benzoyl peroxide may also be added to the formulations and the formulations may be useful as an acne medication.
- the systems of this invention may also be formulated with barrier compounds to form barrier creams and lotions.
- Materials which may be added to provide barrier protection for use as skin barriers to protect against diaper rash include but are not limited to 0.1 to 60% aldioxa, allantoin, aluminum acetate, aluminum hydroxide, bismuth subnitrate, boric acid, calamine, cellulose (microporous), cholecalciferol, cocoa butter, cod liver oil (in combination), colloidal oatmeal, cysteine hydrochloride, dexpanthenol, dimethicone, glycerin kaolin, lanolin (in combination), live yeast cell derivative, mineral oil, peruvian balsam, peruvian balsam oil, petrolatum, protein hydrolysate (1-leucine, 1 -isoleucine, 1 -methionine, 1-phenylalanine, and 1-tyrosine), racemethionine, shark liver oil, sodium bicarbonate, sulfur, talc, tannic acid, topical starch, vitamin A, white petrolatum, zinc acetate, zinc carbon
- compositions of the present invention may be prepared by a variety of techniques.
- the process can often be as simple as adding the thickener system to the hydroalcoholic solvent at a temperature above the melting point of the surfactant(s), mixing briefly and cooling, although the heating step may not be required. It is often beneficial to hold the mixture at an elevated temperature to ensure complete reaction and association.
- the components are preferably subjected to high shear (e.g., homogenized) for a limited time period while above the melting point of the thickener system followed by low shear mixing while cooling.
- the system should be mixed under high shear long enough to ensure complete mixing and association, however, excessive high shear mixing may result in decreased viscosity and stability.
- the cooling rate may be important depending on the particular thickener system. Certain thickener systems can be homogenized and then allowed to cool slowly, however, rapid cooling appears to work well for most systems.
- the order of adding the components may also affect the stability and viscosity of the system. In general it works well to melt the surfactant(s) of the thickener system with aqueous-insoluble emollients together in one vessel.
- the hydroalcoholic solvent, ionizable polymer, and any aqueous miscible emollients are mixed in a second vessel. Both components are heated above the melting temperature of the thickener system.
- the hot liquid components are mixed together rapidly followed by approximately 1 to 5 minutes of homogenization for typical batches under 500 grams.
- viscosity was measured at 23 °C at ambient pressure using a Brookfield LVDV-T viscometer equipped with a model D Brookfield heliopath and T spindles B-F.
- the spindle and speed was chosen for each particular sample such that the viscometer was operating in the middle of its range. All samples were allowed to equilibrate at 23 °C for 24 hours prior to measurement.
- the viscosity is taken at the lowest speed possible while staying within 20-80% of the viscometer range and more preferably between 30-70% of the range. In all cases the sample size and container geometry was chosen to ensure that there were no wall effects.
- wall effects it is meant the viscosity value is not affected by the container and is essentially equivalent to the viscosity taken in an infinitely large container. For this reason lower viscosity samples required a larger sample size to accommodate the larger spindles.
- the following table outlines preferred spindles for various sample viscosities.
- the viscosity of each sample was taken as the highest relatively stable reading achieved on the first path the spindle traversed using the heliopath adapter.
- the stability of samples was measured 24 hours after conditioning at ambient conditions by placing 12 ml of a formulation that formed a lotion/cream in a 15 ml graduated centrifuge tube. The tube was then centrifuged in a Labofuge B (Heraeus Sepatech GmbH, Model 2650, rotor 2150 and buckets #2101) at 2000 rpm (1545 x g when measured at the longitudinal midpoint of the sample tube) for 30 minutes at 23°C. Stability is recorded as a volume percent separation in the Examples below. Melt Temperature (T m .
- the melt temperature was measured by placing approximately 15 grams sample in a 25 cc sealed glass vial and placing the vial in a water bath. The temperature of the bath was increased periodically in discrete increments and the contents checked after approximately 1 hour at a given temperature. The melt temperature was taken as the temperature at which the mixture became very low in viscosity.
- compositions of this invention are preferably formulated with emollients to achieve a moisturized but relatively dry feel. Lotions with excessive emollients tend to be perceived as greasy and can result in excessive clumping of the powder under surgical gloves.
- the preferred formulations of this invention do not provide a tacky or sticky feel even in high humidity environments throughout the application process.
- the invention formulations preferably yield a smooth, soft, non-tacky, and moisturized feeling.
- the polymer was dissolved in the hydroalcoholic solvent (ethanol/water of the ratios indicated in the table below) and heated to 70°C.
- the "INCROMINE BB” was heated in a separate vessel to 70°C.
- the hot polymer solution was added to the surfactant while subjecting the contents to high shear on a Silverson L4R homogenizer available from Silverson Machines, Waterside England.
- a sulfonic acid polymer available from Henkel as HSP-1180 (2- methyl-2-((oxo-2-propenyl)amino)-l -propane sulfonic acid, which was supplied as a solution in water, the polymer concentration was approximately 14% by weight) was combined in various ratios with a behenamidopropyldimethylamine (available as "INCROMINE BB" from Croda Inc., Parsippany NJ).
- the procedure of Example 1 was used with the following results. All compositions produced appeared as an opaque white lotion/cream.
- Polymer EEmmulsifier Solvent Ethanol/water Viscosity Stability wt. (g) wt. wt. (g) wt. ratio (cps) (%) (°C)
- duPont deNemors of Wilmington, Delaware 22.0 grams of polystyrylethyl methacrylate having a molecular weight of about 10,000, which is available from Sartomer of Exton, Pennsylvania, or Polymer Chemistry Innovations of Arlington, Arizona.
- the mixture was deoxygenated by purging with one liter per minute nitrogen for two minutes.
- the bottle was sealed and placed in a rotating water bath at 55°C for 24 hours.
- Ethyl acetate (220.0 grams) was added to dilute the polymer to 36.65% solids and 52,500 cps.
- the inherent viscosity was measured as 0.685 dl/g in ethyl acetate at a concentration of 0.2 g/dl.
- the test procedure and apparatus used are described in "Textbook of Polymer Science"; F.W. Billmeyer, Ed.; Wiley-Interscience, NY; 2nd Edition; 84-85 (1971).
- This terpolymer was combined in various ratios with stearoyl sarcoine surfactant (available as "HAMPOSYL S” from Hampshire Chemical Corp., Lexington MA).
- HAMPOSYL S stearoyl sarcoine surfactant
- a 2.8% by weight polymer solution in ethanol was prepared by heating at 70°C for several hours.
- a 10% by weight solution of surfactant was prepared by mixing 13 grams of "HAMPOSYL S" in 117 grams of ethanol/water in the weight ratios shown in the following table. The following results were observed:
Abstract
Description
Claims
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CA002275168A CA2275168A1 (en) | 1997-01-09 | 1997-12-22 | Hydroalcoholic compositions thickened using surfactant/polymer complexes |
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US6183766B1 (en) | 1999-02-12 | 2001-02-06 | The Procter & Gamble Company | Skin sanitizing compositions |
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Also Published As
Publication number | Publication date |
---|---|
AU5385898A (en) | 1998-08-03 |
JP4560594B2 (en) | 2010-10-13 |
EP1464222A3 (en) | 2005-02-16 |
DE69730621T2 (en) | 2005-09-22 |
EP0963157A1 (en) | 1999-12-15 |
EP0963157B1 (en) | 2004-09-08 |
EP0963157B2 (en) | 2013-04-10 |
AU733138B2 (en) | 2001-05-10 |
US5908619A (en) | 1999-06-01 |
EP1464222A2 (en) | 2004-10-06 |
DE69730621D1 (en) | 2004-10-14 |
DE69730621T3 (en) | 2013-09-05 |
CA2275168A1 (en) | 1998-07-16 |
JP2001508443A (en) | 2001-06-26 |
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