WO1998037111A1 - Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein - Google Patents
Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein Download PDFInfo
- Publication number
- WO1998037111A1 WO1998037111A1 PCT/US1998/002696 US9802696W WO9837111A1 WO 1998037111 A1 WO1998037111 A1 WO 1998037111A1 US 9802696 W US9802696 W US 9802696W WO 9837111 A1 WO9837111 A1 WO 9837111A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- monomer
- product
- macromer
- vinyl
- moiety
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/04—Polymers provided for in subclasses C08C or C08F
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/04—Polymers provided for in subclasses C08C or C08F
- C08F290/044—Polymers of aromatic monomers as defined in group C08F12/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/04—Polymers provided for in subclasses C08C or C08F
- C08F290/046—Polymers of unsaturated carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J151/00—Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98914224A EP0961794A1 (en) | 1997-02-21 | 1998-02-23 | Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein |
CA002276339A CA2276339A1 (en) | 1997-02-21 | 1998-02-23 | Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein |
JP53672598A JP2001513124A (en) | 1997-02-21 | 1998-02-23 | Pressure-sensitive adhesive transdermal composite and pressure-sensitive adhesive used in it |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80504297A | 1997-02-21 | 1997-02-21 | |
US08/805,042 | 1997-02-21 | ||
US08/803,594 US5951999A (en) | 1997-02-21 | 1997-02-21 | Transdermal pressure sensitive adhesive drug delivery system |
US08/803,594 | 1997-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998037111A1 true WO1998037111A1 (en) | 1998-08-27 |
Family
ID=27122609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/002696 WO1998037111A1 (en) | 1997-02-21 | 1998-02-23 | Transdermal pressure sensitive adhesive drug delivery system and pressure sensitive adhesive used therein |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0961794A1 (en) |
JP (1) | JP2001513124A (en) |
KR (1) | KR20000070375A (en) |
CA (1) | CA2276339A1 (en) |
WO (1) | WO1998037111A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001192631A (en) * | 2000-01-04 | 2001-07-17 | Nitto Denko Corp | Graft-copolymer adhesive, adhesive tape for medical purposes using the same, and transdermal absorption agent |
WO2003006568A1 (en) * | 2001-07-09 | 2003-01-23 | 3M Innovative Properties Company | Pyrrolidonoethyl (meth)acrylate containing pressure sensitive adhesive compositions |
WO2004069141A2 (en) * | 2003-02-05 | 2004-08-19 | Strakan Limited | Transdermal granisetron |
WO2005011766A1 (en) * | 2003-07-31 | 2005-02-10 | Scimed Life Systems, Inc. | Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents |
DE102005056393A1 (en) * | 2005-11-24 | 2007-05-31 | Grünenthal GmbH | Pressure-sensitive adhesive, useful particularly for plasters and transdermal drug-delivery systems, contains specific multicyclic hydrocarbon substituted by polar groups |
US8246981B2 (en) | 2005-05-18 | 2012-08-21 | Abeille Pharamaceuticals, Inc. | Transdermal method and patch for emesis |
US10792246B2 (en) | 2018-06-27 | 2020-10-06 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11786508B2 (en) | 2016-12-31 | 2023-10-17 | Bioxcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
US11890272B2 (en) | 2019-07-19 | 2024-02-06 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010007975A (en) * | 2000-10-31 | 2001-02-05 | 장진환 | Straight line type window |
GB2402394B (en) * | 2002-03-25 | 2005-12-07 | Nat Starch Chem Invest | Rubber-acrylic adhesive formulation |
JP6114004B2 (en) * | 2011-11-10 | 2017-04-12 | 日東電工株式会社 | Adhesive composition and adhesive sheet |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554324A (en) * | 1982-09-16 | 1985-11-19 | Minnesota Mining And Manufacturing Co. | Acrylate copolymer pressure-sensitive adhesive composition and sheet materials coated therewith |
EP0554106A1 (en) * | 1992-01-31 | 1993-08-04 | Adhesives Research, Inc. | Water-inactivatable, pressure sensitive adhesive |
US5242951A (en) * | 1989-12-28 | 1993-09-07 | Nitto Denko Corporation | Estrogen-containing gel preparation |
WO1995014746A2 (en) * | 1993-11-29 | 1995-06-01 | Adhesives Research, Inc. | Water-soluble pressure sensitive adhesive |
EP0728780A2 (en) * | 1995-02-24 | 1996-08-28 | Röhm Gmbh | Graftpolymers with emulgator properties |
EP0732100A2 (en) * | 1995-03-17 | 1996-09-18 | Adhesives Research, Inc. | Drug flux enhancer-tolerant pressure sensitive adhesive composition |
-
1998
- 1998-02-23 JP JP53672598A patent/JP2001513124A/en active Pending
- 1998-02-23 CA CA002276339A patent/CA2276339A1/en not_active Abandoned
- 1998-02-23 KR KR1019997006608A patent/KR20000070375A/en not_active Application Discontinuation
- 1998-02-23 WO PCT/US1998/002696 patent/WO1998037111A1/en not_active Application Discontinuation
- 1998-02-23 EP EP98914224A patent/EP0961794A1/en not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554324A (en) * | 1982-09-16 | 1985-11-19 | Minnesota Mining And Manufacturing Co. | Acrylate copolymer pressure-sensitive adhesive composition and sheet materials coated therewith |
US5242951A (en) * | 1989-12-28 | 1993-09-07 | Nitto Denko Corporation | Estrogen-containing gel preparation |
EP0554106A1 (en) * | 1992-01-31 | 1993-08-04 | Adhesives Research, Inc. | Water-inactivatable, pressure sensitive adhesive |
WO1995014746A2 (en) * | 1993-11-29 | 1995-06-01 | Adhesives Research, Inc. | Water-soluble pressure sensitive adhesive |
EP0728780A2 (en) * | 1995-02-24 | 1996-08-28 | Röhm Gmbh | Graftpolymers with emulgator properties |
EP0732100A2 (en) * | 1995-03-17 | 1996-09-18 | Adhesives Research, Inc. | Drug flux enhancer-tolerant pressure sensitive adhesive composition |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001192631A (en) * | 2000-01-04 | 2001-07-17 | Nitto Denko Corp | Graft-copolymer adhesive, adhesive tape for medical purposes using the same, and transdermal absorption agent |
JP4633879B2 (en) * | 2000-01-04 | 2011-02-16 | 日東電工株式会社 | Transdermal absorption preparation |
WO2003006568A1 (en) * | 2001-07-09 | 2003-01-23 | 3M Innovative Properties Company | Pyrrolidonoethyl (meth)acrylate containing pressure sensitive adhesive compositions |
US6902740B2 (en) | 2001-07-09 | 2005-06-07 | 3M Innovative Properties Company | Pyrrolidonoethyl (meth)acrylate containing pressure sensitive adhesive compositions |
WO2004069141A2 (en) * | 2003-02-05 | 2004-08-19 | Strakan Limited | Transdermal granisetron |
WO2004069141A3 (en) * | 2003-02-05 | 2004-10-07 | Strakan Ltd | Transdermal granisetron |
HRP20050695B1 (en) * | 2003-02-05 | 2013-11-08 | Strakan International Limited | Transdermal granisetron |
KR100893158B1 (en) * | 2003-02-05 | 2009-04-16 | 스트라칸 인터네셔널 리미티드 | Transdermal granisetron |
WO2005011766A1 (en) * | 2003-07-31 | 2005-02-10 | Scimed Life Systems, Inc. | Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents |
US7357940B2 (en) | 2003-07-31 | 2008-04-15 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents |
US8246981B2 (en) | 2005-05-18 | 2012-08-21 | Abeille Pharamaceuticals, Inc. | Transdermal method and patch for emesis |
DE102005056393A1 (en) * | 2005-11-24 | 2007-05-31 | Grünenthal GmbH | Pressure-sensitive adhesive, useful particularly for plasters and transdermal drug-delivery systems, contains specific multicyclic hydrocarbon substituted by polar groups |
US11786508B2 (en) | 2016-12-31 | 2023-10-17 | Bioxcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
US11839604B2 (en) | 2016-12-31 | 2023-12-12 | Bioxcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
US11931340B2 (en) | 2016-12-31 | 2024-03-19 | Bioxcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
US10792246B2 (en) | 2018-06-27 | 2020-10-06 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11478422B2 (en) | 2018-06-27 | 2022-10-25 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11497711B2 (en) | 2018-06-27 | 2022-11-15 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11517524B2 (en) | 2018-06-27 | 2022-12-06 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11559484B2 (en) | 2018-06-27 | 2023-01-24 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11806429B2 (en) | 2018-06-27 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11890272B2 (en) | 2019-07-19 | 2024-02-06 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Also Published As
Publication number | Publication date |
---|---|
EP0961794A1 (en) | 1999-12-08 |
CA2276339A1 (en) | 1998-08-27 |
JP2001513124A (en) | 2001-08-28 |
KR20000070375A (en) | 2000-11-25 |
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