WO1998046588A3 - Compounds and therapies for the prevention of vascular and non-vascular pathologies - Google Patents

Compounds and therapies for the prevention of vascular and non-vascular pathologies Download PDF

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Publication number
WO1998046588A3
WO1998046588A3 PCT/US1998/007063 US9807063W WO9846588A3 WO 1998046588 A3 WO1998046588 A3 WO 1998046588A3 US 9807063 W US9807063 W US 9807063W WO 9846588 A3 WO9846588 A3 WO 9846588A3
Authority
WO
WIPO (PCT)
Prior art keywords
vascular
compounds
tgf
beta
therapies
Prior art date
Application number
PCT/US1998/007063
Other languages
French (fr)
Other versions
WO1998046588A2 (en
Inventor
David J Grainger
James C Metcalfe
Sudhakar Kasina
Original Assignee
Neorx Corp
David J Grainger
James C Metcalfe
Sudhakar Kasina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neorx Corp, David J Grainger, James C Metcalfe, Sudhakar Kasina filed Critical Neorx Corp
Priority to AU69598/98A priority Critical patent/AU6959898A/en
Publication of WO1998046588A2 publication Critical patent/WO1998046588A2/en
Publication of WO1998046588A3 publication Critical patent/WO1998046588A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/495—Transforming growth factor [TGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis

Abstract

The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compounds that elevate TGF-beta levels, as well as pharmaceutical compositions comprising compounds that elevate TGF-beta levels, and methods for detecting diseases associated with endothelial cell activation.
PCT/US1998/007063 1997-04-11 1998-04-09 Compounds and therapies for the prevention of vascular and non-vascular pathologies WO1998046588A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69598/98A AU6959898A (en) 1997-04-11 1998-04-09 Compounds and therapies for the prevention of vascular and non-vascular pathol ogies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4385297P 1997-04-11 1997-04-11
US60/043,852 1997-04-11

Publications (2)

Publication Number Publication Date
WO1998046588A2 WO1998046588A2 (en) 1998-10-22
WO1998046588A3 true WO1998046588A3 (en) 1999-01-07

Family

ID=21929208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/007063 WO1998046588A2 (en) 1997-04-11 1998-04-09 Compounds and therapies for the prevention of vascular and non-vascular pathologies

Country Status (3)

Country Link
US (5) US6117911A (en)
AU (1) AU6959898A (en)
WO (1) WO1998046588A2 (en)

Cited By (1)

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