WO1998052614A3 - Composition and method for enhancing transport across biological membranes - Google Patents

Composition and method for enhancing transport across biological membranes Download PDF

Info

Publication number
WO1998052614A3
WO1998052614A3 PCT/US1998/010571 US9810571W WO9852614A3 WO 1998052614 A3 WO1998052614 A3 WO 1998052614A3 US 9810571 W US9810571 W US 9810571W WO 9852614 A3 WO9852614 A3 WO 9852614A3
Authority
WO
WIPO (PCT)
Prior art keywords
transport
biological
membrane
polymer
subunits
Prior art date
Application number
PCT/US1998/010571
Other languages
French (fr)
Other versions
WO1998052614A2 (en
Inventor
Jonathan B Rothbard
Paul A Wender
Original Assignee
Univ Leland Stanford Junior
Jonathan B Rothbard
Paul A Wender
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Jonathan B Rothbard, Paul A Wender filed Critical Univ Leland Stanford Junior
Priority to JP55071698A priority Critical patent/JP2002502376A/en
Priority to AT98923711T priority patent/ATE251913T1/en
Priority to DE69818987T priority patent/DE69818987T2/en
Priority to GB9923841A priority patent/GB2341390B/en
Priority to AU75938/98A priority patent/AU734827B2/en
Priority to IL13294198A priority patent/IL132941A0/en
Priority to CA002291074A priority patent/CA2291074C/en
Priority to BR9809138-7A priority patent/BR9809138A/en
Priority to KR1019997010772A priority patent/KR20010012809A/en
Priority to EP98923711A priority patent/EP0975370B9/en
Publication of WO1998052614A2 publication Critical patent/WO1998052614A2/en
Publication of WO1998052614A3 publication Critical patent/WO1998052614A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In one embodiment, the polymer consists of from 6 to 25 subunits, at 50 % of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in non-conjugated form. The transport-enhancing polymers are exemplified, in a preferred embodiment, by peptides in which arginine residues constitute the subunits. Such a polyarginine peptide may be composed of either all D-, all L- or mixed D- and L-arginines, any may include additional amino acids. More preferably, at least one, and preferably all of the subunits are D-arginine residues, to enhance biological stability of the polymer during transit of the conjugate of its biological target.
PCT/US1998/010571 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes WO1998052614A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP55071698A JP2002502376A (en) 1997-05-21 1998-05-21 Compositions and methods for enhancing transport across biological membranes
AT98923711T ATE251913T1 (en) 1997-05-21 1998-05-21 COMPOSITION AND METHOD FOR DELAYING TRANSPORT THROUGH BIOLOGICAL MEMBRANES
DE69818987T DE69818987T2 (en) 1997-05-21 1998-05-21 COMPOSITION AND METHOD FOR DELAYING THE TRANSPORT BY BIOLOGICAL MEMBRANES
GB9923841A GB2341390B (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes
AU75938/98A AU734827B2 (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes
IL13294198A IL132941A0 (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes
CA002291074A CA2291074C (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes
BR9809138-7A BR9809138A (en) 1997-05-21 1998-05-21 Conjugate and method to increase the transport of a selected compound across a biological membrane
KR1019997010772A KR20010012809A (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes
EP98923711A EP0975370B9 (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4734597P 1997-05-21 1997-05-21
US60/047,345 1997-05-21

Publications (2)

Publication Number Publication Date
WO1998052614A2 WO1998052614A2 (en) 1998-11-26
WO1998052614A3 true WO1998052614A3 (en) 1999-03-18

Family

ID=21948441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/010571 WO1998052614A2 (en) 1997-05-21 1998-05-21 Composition and method for enhancing transport across biological membranes

Country Status (15)

Country Link
US (5) US6306993B1 (en)
EP (1) EP0975370B9 (en)
JP (1) JP2002502376A (en)
KR (1) KR20010012809A (en)
CN (1) CN1263473A (en)
AT (1) ATE251913T1 (en)
AU (1) AU734827B2 (en)
BR (1) BR9809138A (en)
CA (1) CA2291074C (en)
DE (1) DE69818987T2 (en)
ES (1) ES2210761T3 (en)
GB (1) GB2341390B (en)
IL (1) IL132941A0 (en)
PL (1) PL337033A1 (en)
WO (1) WO1998052614A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974774B2 (en) 2004-03-03 2015-03-10 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport

Families Citing this family (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090947A (en) 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
CN1260006A (en) 1996-02-26 2000-07-12 加利福尼亚州技术学院 Complex formation between dsDNA and oligomer of heterocycles
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
ATE251913T1 (en) * 1997-05-21 2003-11-15 Univ Leland Stanford Junior COMPOSITION AND METHOD FOR DELAYING TRANSPORT THROUGH BIOLOGICAL MEMBRANES
US7135191B2 (en) * 1997-09-04 2006-11-14 Zsolt Istvan Hertelendy Urogenital or anorectal transmucosal vaccine delivery system
US6958148B1 (en) * 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
IL138214A0 (en) 1998-03-09 2001-10-31 Zealand Pharmaceuticals As Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
JP2002518521A (en) 1998-06-20 2002-06-25 ワシントン・ユニバーシティ Membrane permeable peptide complexes for medical image analysis, diagnosis and therapy
US8038984B2 (en) 1998-06-20 2011-10-18 Washington University Membrane-permeant peptide complexes for treatment of sepsis
US6589503B1 (en) 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US7306784B2 (en) 1998-06-20 2007-12-11 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
CA2388991A1 (en) * 1998-11-11 2001-04-19 Peter E. Nielsen Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
DK173006B1 (en) * 1998-11-11 1999-11-01 Ke Burgmann As Method and plant for producing wall material for use in the manufacture of compensators, in particular for flue gas channels, as well as compensator material and compensator produced by the method
US7018654B2 (en) * 1999-03-05 2006-03-28 New River Pharmaceuticals Inc. Pharmaceutical composition containing an active agent in an amino acid copolymer structure
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
NZ514592A (en) * 1999-04-05 2004-02-27 Millennium Pharm Inc Formulation arrays and use thereof
EP1656945A1 (en) * 1999-06-05 2006-05-17 The Board Of Trustees Of The Leland Stanford Junior University Pharmaceutical composition comprising oligoarginine
IL141250A0 (en) * 1999-06-05 2002-03-10 Univ Leland Stanford Junior Method and composition for inhibiting cardiovascular cell proliferation
MXPA02000890A (en) * 1999-07-28 2003-10-15 Transform Pharmaceuticals Inc Sample arrays and highthroughput testing thereof to detect interactions.
US20050226890A1 (en) * 1999-08-12 2005-10-13 Cohen David I Tat-based vaccine compositions and methods of making and using same
KR100345214B1 (en) * 1999-08-17 2002-07-25 이강춘 The nasal transmucosal delivery of peptides conjugated with biocompatible polymers
US7229961B2 (en) 1999-08-24 2007-06-12 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into ocular tissues
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
US6730293B1 (en) 1999-08-24 2004-05-04 Cellgate, Inc. Compositions and methods for treating inflammatory diseases of the skin
AU769315B2 (en) * 1999-08-24 2004-01-22 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
US6864355B1 (en) 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
AU7773100A (en) * 1999-10-13 2001-04-23 Pantheco A/S Gene selection using pnas
AU765588C (en) 1999-11-24 2004-12-16 Immunogen, Inc. Cytotoxic agents comprising taxanes and their therapeutic use
JP2003516151A (en) * 1999-11-29 2003-05-13 エイブイアイ バイオファーマ， インコーポレイテッド Uncharged antisense oligonucleotides targeted to bacterial 16S and 23S rRNA and uses thereof
WO2001049775A2 (en) * 2000-01-04 2001-07-12 Avi Biopharma, Inc. Antisense antibacterial cell division composition and method
US6977723B2 (en) 2000-01-07 2005-12-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US7108970B2 (en) 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US20020009491A1 (en) * 2000-02-14 2002-01-24 Rothbard Jonathan B. Compositions and methods for enhancing drug delivery across biological membranes and tissues
AU2001238346A1 (en) 2000-02-15 2001-08-27 Genzyme Corporation Modification of biopolymers for improved drug delivery
US6749865B2 (en) 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
DE60128551D1 (en) 2000-03-16 2007-07-05 Genesoft Inc LOADED COMPOUNDS WITH A NUCLEIC ACID BINDING UNIT AND ITS USES
AU2001248281A1 (en) * 2000-04-06 2001-10-23 Pantheco A/S Pharmaceutical composition of modified pna molecules
GB0008563D0 (en) 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
US7049395B2 (en) 2000-05-02 2006-05-23 Yale University Anti-inflammatory compounds and uses thereof
KR20020097241A (en) 2000-05-04 2002-12-31 에이브이아이 바이오파마 인코포레이티드 Splice-region antisense composition and method
US20040220100A1 (en) * 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems
DK2364734T3 (en) * 2000-07-21 2017-10-30 Revance Therapeutics Inc Biological multicomponent transport systems
WO2005090392A1 (en) * 2004-03-16 2005-09-29 Inist Inc. Tat-based tolerogen compositions and methods of making and using same
WO2006033665A1 (en) * 2004-03-16 2006-03-30 Inist Inc. Tat-based vaccine compositions and methods of making and using same
US7163918B2 (en) 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
US20020099013A1 (en) * 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
US20050059031A1 (en) * 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
EP2085781B2 (en) * 2000-10-06 2020-03-11 Life Technologies Corporation Transfectable micelles containing semiconductor nanocrystals
US7033597B2 (en) * 2000-10-13 2006-04-25 Université de Lausanne Intracellular delivery of biological effectors
GB0026924D0 (en) 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
JP2004514427A (en) * 2000-11-24 2004-05-20 パンセコ・アクティーゼルスカブ PNA analog
WO2002053574A2 (en) * 2001-01-05 2002-07-11 Pantheco A/S Modified pna molecules
US7585834B2 (en) 2001-02-16 2009-09-08 The Board Of Trustees Of The Leland Stanford Junior University Transporters comprising spaced arginine moieties
US6825166B2 (en) 2001-03-23 2004-11-30 Tapestry Pharmaceuticals, Inc. Molecular conjugates for use in treatment of cancer
WO2002088119A1 (en) 2001-04-26 2002-11-07 Genesoft Pharmaceuticals, Inc Halogen-substituted thienyl compounds
AU2002312371A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Aryl-benzimidazole compounds having antiinfective activity
US6777425B2 (en) 2001-06-13 2004-08-17 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
EP1470119A4 (en) 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc Benzothiophene compounds having antiinfective activity
WO2002101007A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
US7033991B2 (en) * 2001-07-16 2006-04-25 Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College Inhibiting furin with polybasic peptides
US8815793B2 (en) * 2001-07-20 2014-08-26 Northwestern University Polymeric compositions and related methods of use
US7858679B2 (en) * 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
US7618937B2 (en) * 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
MXPA04001142A (en) * 2001-08-03 2004-09-13 Univ Leland Stanford Junior Bi-directional synthesis of oligoguanidine transport agents.
US20060264608A1 (en) * 2001-08-03 2006-11-23 Wender Paul A Bi-directional synthesis of oligoguanidine transport agents
EP1425577A4 (en) 2001-08-10 2004-12-29 Symyx Technologies Inc Apparatuses and methods for creating and testing pre-formulations and systems for same
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
EP1446008A4 (en) * 2001-10-18 2006-08-16 Essentia Biosystems Inc Compositions and methods for controlled release
MXPA04005611A (en) 2001-12-11 2005-04-19 Cellgate Inc Guanidinium transport reagents and conjugates.
WO2003059192A2 (en) 2001-12-21 2003-07-24 The Trustees Of Columbia University In The City Of New York C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis
DE10201862A1 (en) * 2002-01-18 2003-08-07 Deutsches Krebsforsch Conjugate used to treat prokaryotic infections
US7026166B2 (en) 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US20050181474A1 (en) * 2002-01-30 2005-08-18 Frank J. Giordano Transport peptides and uses therefor
EP1572902B1 (en) 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
ATE508188T1 (en) 2002-02-01 2011-05-15 Life Technologies Corp OLIGONUCLEOTIDE COMPOSITIONS WITH IMPROVED EFFECTIVENESS
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
ES2500117T3 (en) * 2002-02-22 2014-09-30 Shire Llc Novel sustained release pharmaceutical compounds to prevent the abuse of controlled substances
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US20050226821A1 (en) * 2002-02-22 2005-10-13 Jacob Waugh Cosmetic formulations containing l-arginine oligomers
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
WO2003092736A2 (en) * 2002-05-01 2003-11-13 Pantheco A/S Peptide nucleic acid conjugates with transporter peptides
SE0201863D0 (en) * 2002-06-18 2002-06-18 Cepep Ab Cell penetrating peptides
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US7033602B1 (en) 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7056523B1 (en) 2002-06-21 2006-06-06 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
US7794743B2 (en) 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
WO2004030610A2 (en) * 2002-07-11 2004-04-15 The Trustees Of Columbia University In The City Of New York Compositions and methods for the intracellular delivery of antibodies
US20080171012A1 (en) * 2007-01-11 2008-07-17 Phillip Messersmith Fouling Resistant Coatings and Methods of Making Same
US8911831B2 (en) * 2002-07-19 2014-12-16 Northwestern University Surface independent, surface-modifying, multifunctional coatings and applications thereof
WO2004009666A2 (en) * 2002-07-19 2004-01-29 The Regents Of The University Of California Dendrimers as molecular translocators
US7498349B2 (en) 2002-08-02 2009-03-03 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
BR0313197A (en) 2002-08-02 2005-08-09 Immunogen Inc Cytotoxic agents containing potent taxanes and their therapeutic use
AU2003259848A1 (en) * 2002-08-15 2004-03-03 Campbell, Samantha A Apicomplexan pathways, inhibitors, and drug delivery
EE200200531A (en) * 2002-09-17 2004-04-15 O� InBio Production and use of therapeutic intracellular antibodies
EP1562931A2 (en) 2002-10-25 2005-08-17 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
WO2004044139A2 (en) 2002-11-05 2004-05-27 Isis Parmaceuticals, Inc. Modified oligonucleotides for use in rna interference
DK1585548T3 (en) 2002-12-09 2018-09-03 Abraxis Bioscience Llc COMPOSITIONS AND PROCEDURES FOR THE DELIVERY OF PHARMACOLOGICAL AGENTS
EP1587529A4 (en) 2002-12-10 2009-08-12 Oscient Pharmaceuticals Corp Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
EP1583562B1 (en) * 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
US7704756B2 (en) 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
US6969514B2 (en) * 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US7166692B2 (en) * 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
CA2523672C (en) 2003-04-29 2012-07-17 Avi Biopharma, Inc. Compositions for enhancing transport of molecules into cells
KR101170840B1 (en) * 2003-05-29 2012-08-03 샤이어 엘엘씨 Abuse resistant amphetamine compounds
US8008255B2 (en) * 2003-05-30 2011-08-30 Amylin Pharmaceuticals, Inc. Methods and compositions for enhanced transmucosal delivery of peptides and proteins
WO2005013905A2 (en) * 2003-08-07 2005-02-17 Avi Biopharma, Inc. SENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING ssRNA VIRAL INFECTION
US20050222068A1 (en) * 2003-10-23 2005-10-06 Mourich Dan V Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
EP1675555A4 (en) * 2003-09-30 2011-03-09 Shire Llc Pharmaceutical compositions for prevention of overdose or abuse
US7985401B2 (en) * 2003-10-31 2011-07-26 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US7431915B2 (en) * 2003-10-31 2008-10-07 The Regents Of The University Of California Peptides whose uptake by cells is controllable
WO2005046730A2 (en) * 2003-11-12 2005-05-26 The University Of Georgia Research Foundation, Inc. Biotin-facilitated transport into gram negative bacteria
WO2005072527A2 (en) * 2004-01-23 2005-08-11 Avi Biopharma, Inc. Antisense oligomers and methods for inducing immune tolerance and immunosuppression
US20050192210A1 (en) * 2004-03-01 2005-09-01 Rothbard Jonathan B. Compositions and methods for treating diseases
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
PT2656859E (en) 2004-03-03 2016-02-24 Revance Therapeutics Inc Topical application and transdermal delivery of botulinum toxins
KR100578732B1 (en) 2004-03-05 2006-05-12 학교법인 포항공과대학교 Inositol-based molecular transporters and processes for the preparation thereof
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US7402574B2 (en) * 2004-03-12 2008-07-22 Avi Biopharma, Inc. Antisense composition and method for treating cancer
US20050288246A1 (en) * 2004-05-24 2005-12-29 Iversen Patrick L Peptide conjugated, inosine-substituted antisense oligomer compound and method
WO2005118884A1 (en) * 2004-05-28 2005-12-15 The United States Of America As Represented By The Secretary Of The Navy A method for the rapid diagnosis of infectious disease by detection and quantitation of microorganism induced cytokines
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
DK1766012T3 (en) * 2004-07-02 2011-09-19 Avi Biopharma Inc Antisense antibacterial method and compound
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US8129352B2 (en) * 2004-09-16 2012-03-06 Avi Biopharma, Inc. Antisense antiviral compound and method for treating ssRNA viral infection
US8357664B2 (en) * 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
US7524829B2 (en) * 2004-11-01 2009-04-28 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US7947772B2 (en) * 2004-11-10 2011-05-24 The Regents Of The University Of Michigan Multiphasic nano-components comprising colorants
US7767017B2 (en) * 2004-11-10 2010-08-03 The Regents Of The University Of Michigan Multi-phasic nanoparticles
US8043480B2 (en) * 2004-11-10 2011-10-25 The Regents Of The University Of Michigan Methods for forming biodegradable nanocomponents with controlled shapes and sizes via electrified jetting
EP1656951A1 (en) * 2004-11-12 2006-05-17 Xigen S.A. Conjugates with enhanced cell uptake activity
WO2006055531A2 (en) * 2004-11-16 2006-05-26 Northwestern University Peptidomimetic polymers for antifouling surfaces
CA2596506C (en) 2005-02-09 2021-04-06 Avi Biopharma, Inc. Antisense composition and method for treating muscle atrophy
DK1988167T3 (en) 2005-02-17 2020-07-13 Univ Sorbonne Intracellular inhibitory peptides
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
PT2360258E (en) * 2005-02-18 2015-01-13 Angiochem Inc Aprotinin polypeptides for transporting a compound across the blood-brain barrier
ATE507236T1 (en) 2005-03-03 2011-05-15 Revance Therapeutics Inc COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL ADMINISTRATION OF AN OLIGOPEPTIDE
US9180081B2 (en) 2005-03-03 2015-11-10 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
EP1865978A4 (en) * 2005-03-21 2012-01-25 Univ Columbia New neuronal pain pathway
US20060240032A1 (en) * 2005-03-31 2006-10-26 Hinrichs David J Immunomodulating compositions and methods for use in the treatment of human autoimmune diseases
DE602006017237D1 (en) 2005-04-05 2010-11-11 Allergan Inc Clostridientoxinaktivitätstests
KR100699279B1 (en) 2005-04-28 2007-03-23 학교법인 포항공과대학교 Molecular transporters based on sugar or its analogues and processes for the preparation thereof
US7973084B2 (en) * 2005-04-28 2011-07-05 Postech Academy-Industrial Foundation Molecular transporters based on alditol or inositol and processes for the preparation thereof
US20060293268A1 (en) * 2005-05-05 2006-12-28 Rieder Aida E Antisense antiviral compounds and methods for treating foot and mouth disease
US7790694B2 (en) * 2005-07-13 2010-09-07 Avi Biopharma Inc. Antisense antibacterial method and compound
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
DK2433653T3 (en) * 2005-07-15 2019-08-19 Angiochem Inc Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
US7538187B2 (en) * 2005-08-01 2009-05-26 E. I. Du Pont De Nemours And Company Coloring compositions with peptide-based dispersants and binders
WO2007030691A2 (en) * 2005-09-08 2007-03-15 Avi Biopharma, Inc. Antisense antiviral compound and method for treating picornavirus infection
EP1937278B1 (en) * 2005-09-08 2012-07-25 AVI BioPharma, Inc. Antisense antiviral compound and method for treating picornavirus infection
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007038172A2 (en) * 2005-09-23 2007-04-05 Nitto Denko Corporation Guanidinium carriers
WO2007038169A2 (en) * 2005-09-23 2007-04-05 Nitto Denko Corporation Multi-valent guanidinium compounds for molecular translocation across cellular membranes and epithelial tissues
US7700565B2 (en) * 2005-09-23 2010-04-20 Nitto Denko Corporation Peptide nucleic acid based guanidinium compounds
US8883507B2 (en) 2005-10-18 2014-11-11 The Regents Of The University Of Colorado Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells
US8501704B2 (en) 2005-11-08 2013-08-06 Sarepta Therapeutics, Inc. Immunosuppression compound and treatment method
US8568740B2 (en) * 2005-11-17 2013-10-29 Revance Therapeutics, Inc. Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins
FI20055653A (en) * 2005-12-08 2007-06-09 Wallac Oy The labeling reagent
FI20065030L (en) * 2006-01-17 2007-07-18 Wallac Oy Neutral labeling reagents and conjugates derived from them
US7732539B2 (en) * 2006-02-16 2010-06-08 National Science Foundation Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives
WO2008069824A2 (en) * 2006-02-27 2008-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for transport of molecules with enhanced release properties across biological barriers
US8785407B2 (en) * 2006-05-10 2014-07-22 Sarepta Therapeutics, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
JP2010505741A (en) * 2006-05-10 2010-02-25 エイブイアイ バイオファーマ， インコーポレイテッド Oligonucleotide analogues with cationic intersubunit linkages
WO2007149310A2 (en) * 2006-06-16 2007-12-27 The Regents Of The University Of Michigan Multiphasic biofunctional nano-components and methods for use thereof
JP5597836B2 (en) 2006-08-04 2014-10-01 ケンジー ナッシュ コーポレイション Biomimetic compound and synthesis method thereof
US8563117B2 (en) * 2006-08-04 2013-10-22 Phillip B. Messersmith Biomimetic modular adhesive complex: materials, methods and applications therefore
JP2010504929A (en) * 2006-09-27 2010-02-18 ボッティ，パオロ Means and methods for enhancing delivery to biological systems
MX2009007068A (en) * 2006-12-29 2009-07-10 Revance Therapeutics Inc Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from hiv-tat.
US20100093639A1 (en) * 2006-12-29 2010-04-15 Revance Therapeutics, Inc. Transport Molecules Using Reverse Sequence HIV-TAT Polypeptides
JP2010516707A (en) * 2007-01-19 2010-05-20 カイ ファーマシューティカルズ インコーポレーティッド Modification methods for increasing the stability and delivery efficiency of peptide compositions
GB0702020D0 (en) * 2007-02-02 2007-03-14 Novabiotics Ltd Peptides and their use
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US8383092B2 (en) * 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
JP2010529843A (en) * 2007-06-03 2010-09-02 オンコティーエックス インコーポレイテッド Cancer-associated isoforms of the transcription factor complex as biomarkers and drug targets
US20100016215A1 (en) * 2007-06-29 2010-01-21 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
ES2694726T3 (en) * 2007-06-29 2018-12-26 Sarepta Therapeutics, Inc. Tissue specific peptide conjugates and methods
DE102007041655A1 (en) 2007-09-03 2009-03-05 Medicyte Gmbh Propagation of primary cells and their use
ES2313848B1 (en) * 2007-10-24 2010-03-22 Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria NEW ANTIVIRAL PEPTIDES THAT PREVENT THE UNION OF VIRUS TO DLC8.
US20110160146A1 (en) * 2008-02-07 2011-06-30 National Institute of Health (NIH) Conjungation of Small Molecules to Octaarginine Transporters for Overcoming Multi-Drug Resistance
BR122012027456A2 (en) 2008-03-14 2015-07-14 Allergan Inc Pharmaceutical composition comprising botulinum neurotoxin serotype a
TR201905480T4 (en) * 2008-04-18 2019-05-21 Angiochem Inc Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and their respective preparation and use methods.
IL287311B1 (en) * 2008-05-16 2024-02-01 Taiga Biotechnologies Inc Antibodies and processes for preparing the same
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2010011641A2 (en) * 2008-07-21 2010-01-28 The Regents Of The University Of Michigan Microphasic micro-components and methods for controlling morphology via electrified jetting
EP2966084B1 (en) 2008-08-28 2018-04-25 Taiga Biotechnologies, Inc. Modulators of myc, methods of using the same and methods of identifying agents that modulate myc
EP2346896A4 (en) 2008-10-15 2014-06-25 Angiochem Inc Etoposide and doxorubicin conjugates for drug delivery
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
BRPI0922689A2 (en) 2008-12-05 2018-11-06 Angiochem Inc. neurotensin conjugates or neurotensin analogs and uses thereof
CA2746508A1 (en) * 2008-12-17 2010-07-15 Avi Biopharma, Inc. Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
EP2408372B1 (en) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Devices associated with blood sampling
US20120277629A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US8455203B2 (en) 2009-03-13 2013-06-04 Allergan, Inc. Immuno-based retargeted endopeptidase activity assays
KR20200146046A (en) 2009-03-13 2020-12-31 알러간, 인코포레이티드 Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays
DK2411043T3 (en) 2009-03-23 2013-10-21 Pin Pharma Inc TREATMENT OF CANCER WITH IMMUNOSTIMULATORY HIV TAT DERIVATE POLYPEPTIDES
JP2012521279A (en) 2009-03-26 2012-09-13 ビーエル・テクノロジーズ・インコーポレイテッド Non-woven reinforced hollow fiber membrane
RU2011146654A (en) 2009-04-20 2013-05-27 Ангиокем Инк. METHODS FOR TREATING OVARIAN CANCER USING CONJUGATED PRODUCT
EP2437772B1 (en) 2009-06-05 2017-12-06 13Therapeutics, Inc. Immunoregulatory peptides and methods of use
US20110269665A1 (en) 2009-06-26 2011-11-03 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
ES2521440T3 (en) 2009-06-26 2014-11-12 Bl Technologies, Inc. Textile reinforced non-braided hollow fiber membrane
IN2012DN00248A (en) 2009-07-02 2015-05-01 Angiochem Inc
EP2454271A4 (en) 2009-07-15 2015-08-12 Univ California Peptides whose uptake in cells is controllable
ES2607954T3 (en) * 2009-07-29 2017-04-04 Kai Pharmaceuticals, Inc. Therapeutic agents to reduce parathyroid hormone levels
EP3199634A1 (en) 2009-11-13 2017-08-02 Sarepta Therapeutics, Inc. Antisense antiviral compound and method for treating influenza viral infection
US20110130465A1 (en) * 2009-12-01 2011-06-02 Nerites Corporation Coatings for prevention of biofilms
JP5457813B2 (en) * 2009-12-16 2014-04-02 ルネサスエレクトロニクス株式会社 ADPLL circuit, semiconductor device and portable information device
US20140199239A1 (en) * 2010-05-17 2014-07-17 The Regents Of The University Of California Compositions and Methods for in Vivo Imaging
AU2011257980B2 (en) 2010-05-28 2016-06-30 Sarepta Therapeutics, Inc. Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
US8198429B2 (en) 2010-08-09 2012-06-12 Avi Biopharma, Inc. Antisense antiviral compounds and methods for treating a filovirus infection
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
WO2012031243A2 (en) 2010-09-03 2012-03-08 Avi Biopharma, Inc. dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
BR112013004171A2 (en) 2010-09-15 2016-05-10 Bl Technologies Inc process for manufacturing a reinforced hollow fiber membrane and precursor assembly
DE102010041958A1 (en) 2010-10-04 2012-04-05 Medicyte Gmbh Suitable hepatocytes for in vitro genotoxicity tests
CA2807036C (en) 2010-10-14 2018-01-16 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2012050673A1 (en) * 2010-10-14 2012-04-19 Wisconsin Alumni Research Foundation Methods for the treatment of x-linked hypophosphatemia and related disorders
WO2012054841A2 (en) 2010-10-22 2012-04-26 The Regents Of The University Of Michigan Optical devices with switchable particles
EP2637707A4 (en) 2010-11-09 2014-10-01 Kensey Nash Corp Adhesive compounds and methods use for hernia repair
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
US8529814B2 (en) 2010-12-15 2013-09-10 General Electric Company Supported hollow fiber membrane
JP2012131743A (en) * 2010-12-22 2012-07-12 Kyoto Univ Tumor accumulation type anticancer agent
WO2012138879A2 (en) 2011-04-06 2012-10-11 13Therapeutics, Inc. Peptides for the treatment of hearing
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
ES2597081T3 (en) 2011-04-29 2017-01-13 Seventh Sense Biosystems, Inc. Delivery and / or reception of fluids
KR102339196B1 (en) 2011-05-05 2021-12-15 사렙타 쎄러퓨틱스, 인코퍼레이티드 Peptide Oligonucleotide Conjugates
US9161948B2 (en) 2011-05-05 2015-10-20 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
US10202338B2 (en) 2011-06-21 2019-02-12 Evologie Llc Topical compositions for the treatment of dermatological disorders
JP5940542B2 (en) * 2011-08-31 2016-06-29 国立大学法人 岡山大学 Skin introduction system and whitening agent combining cell introduction peptide and skin introduction accelerator
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
TWI429747B (en) * 2011-11-02 2014-03-11 Univ Nat Taiwan Rna virus-derived peptides with modified side chains
KR102271212B1 (en) 2011-11-18 2021-07-01 사렙타 쎄러퓨틱스, 인코퍼레이티드 Functionally-modified oligonucleotides and subunits thereof
EP2782926B1 (en) 2011-11-24 2018-07-04 Positec Power Tools (Suzhou) Co., Ltd Peptide sequence design and use thereof for peptide-mediated sirna delivery
US9321014B2 (en) 2011-12-16 2016-04-26 Bl Technologies, Inc. Hollow fiber membrane with compatible reinforcements
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
US9643129B2 (en) 2011-12-22 2017-05-09 Bl Technologies, Inc. Non-braided, textile-reinforced hollow fiber membrane
US9022229B2 (en) 2012-03-09 2015-05-05 General Electric Company Composite membrane with compatible support filaments
JP6527331B2 (en) 2012-03-16 2019-06-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Target-directed amino acid lipid
KR102081046B1 (en) 2012-03-16 2020-02-25 메르크 파텐트 게엠베하 Aminoacid lipids
US8999454B2 (en) 2012-03-22 2015-04-07 General Electric Company Device and process for producing a reinforced hollow fibre membrane
CA2870711A1 (en) * 2012-04-17 2013-10-24 Brown University Neuroprotective composition and method of use
US9816066B2 (en) 2012-04-24 2017-11-14 The Regents Of The University Of California Method for delivery of small molecules and proteins across the cell wall of algae using molecular transporters
CN114645015A (en) 2012-07-20 2022-06-21 泰加生物工艺学公司 Enhanced reconstitution and autoreconstitution of hematopoietic compartments
WO2014026283A1 (en) 2012-08-14 2014-02-20 Angiochem Inc. Peptide-dendrimer conjugates and uses thereof
US9227362B2 (en) 2012-08-23 2016-01-05 General Electric Company Braid welding
US20150291958A1 (en) 2012-11-15 2015-10-15 Roche Innovation Center Copenhagen A/S Anti apob antisense conjugate compounds
US10029017B2 (en) 2013-01-29 2018-07-24 The Regents Of The University Of California Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
RU2018108405A (en) 2013-01-30 2019-02-26 Ф. Хоффманн-Ля Рош Аг CARBOHYDRATE AND LNA-OLIGONUCLEOTIDE CONJUGATES
CN105102484B (en) 2013-01-30 2020-03-10 艾维拉斯生物科学公司 Selective delivery molecules and methods of use
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
CN103739674A (en) * 2013-04-01 2014-04-23 中国人民解放军军事医学科学院野战输血研究所 Protamine mimic peptide series with low molecular and application thereof
US10370415B2 (en) 2013-04-11 2019-08-06 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US10221216B2 (en) 2013-04-11 2019-03-05 Carnegie Mellon University Template-directed γPNA synthesis process and γPNA targeting compounds
KR101447901B1 (en) * 2013-04-16 2014-10-16 한양대학교 산학협력단 Adipocyte targeted non-viral gene delivery system
EA201501080A1 (en) 2013-06-26 2016-07-29 Ксижен Инфлемейшн Лтд. NEW APPLICATIONS OF POSSIBLE ABILITIES TO PUNCH THE PEPTIDE INHIBITORS IN THE CELL OF JNK SIGNAL TRANSFORMATION TREATMENT FOR THE TREATMENT OF VARIOUS DISEASES
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EP3591054A1 (en) 2013-06-27 2020-01-08 Roche Innovation Center Copenhagen A/S Antisense oligomers and conjugates targeting pcsk9
WO2015051245A1 (en) 2013-10-04 2015-04-09 Pin Pharma, Inc. Immunostimulatory hiv tat derivative polypeptides for use in cancer treatment
GB201401453D0 (en) * 2014-01-28 2014-03-12 Univ Birmingham Transmucosal and transepithelial drug delivery system
GB201401877D0 (en) * 2014-02-04 2014-03-19 Univ Tromsoe Peptides
EP2927685A1 (en) 2014-04-02 2015-10-07 Medicyte GmbH Suitable hepatocytes for in-vitro hepatitis tests
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
KR20160001419A (en) * 2014-06-27 2016-01-06 포항공과대학교 산학협력단 Composition for skin permeation comprising cationic molecular transporters and anionic bioactive substance
US11072681B2 (en) 2014-07-28 2021-07-27 The Regents Of The University Of California Compositions and methods of making polymerizing nucleic acids
US10980744B2 (en) 2014-08-08 2021-04-20 The Regents Of The University Of California High density peptide polymers
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
MA41795A (en) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc EXCLUSION OF AN EXON INDUCED BY ANTISENSE COMPOUNDS IN MYOSTATIN
US10596259B2 (en) 2015-05-20 2020-03-24 The Regents Of The University Of California Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof
US11020417B2 (en) 2015-06-04 2021-06-01 Sarepta Therapeutics, Inc Methods and compounds for treatment of lymphocyte-related diseases and conditions
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
KR20180084782A (en) 2015-10-14 2018-07-25 엑스-써마 인코포레이티드 Compositions and methods for reducing ice crystal formation
ES2857702T3 (en) 2016-03-14 2021-09-29 Hoffmann La Roche Oligonucleotides for reduction of PD-L1 expression
WO2018058091A1 (en) 2016-09-26 2018-03-29 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US10583156B2 (en) 2016-12-02 2020-03-10 Taiga Biotechnologies, Inc. Nanoparticle formulations
BR112019012647A2 (en) 2016-12-19 2019-11-19 Sarepta Therapeutics Inc exon jump oligomer conjugates for muscular dystrophy
FR3064364A1 (en) * 2017-03-27 2018-09-28 S.P.C.M. Sa METHOD OF DETERMINING CATIONIC POLYMERS
WO2019018350A1 (en) 2017-07-17 2019-01-24 Keith Roizman Topical delivery of therapeutic agents comprising cell-penetrating peptides for use for the treatment of age-related macular degeneration and other eye diseases
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
CN108822052A (en) * 2018-05-18 2018-11-16 中国科学技术大学 Non- peptides polyguanidine small molecule and protein import technology based on non-peptides polyguanidine small molecule-protein matter couplet
WO2019245353A1 (en) * 2018-06-22 2019-12-26 재단법인 대구경북과학기술원 Cytokine fusion polypeptide and cytokine library comprising same
GB201900728D0 (en) * 2019-01-18 2019-03-06 Univ Birmingham Drug delivery system
KR20200110576A (en) * 2019-03-15 2020-09-24 재단법인대구경북과학기술원 Immune cells based on cytokines and immunotherapy uses thereof
JPWO2021002408A1 (en) 2019-07-02 2021-01-07
WO2023048236A1 (en) 2021-09-22 2023-03-30 Ａｇｃ株式会社 Peptide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007871A1 (en) * 1990-10-24 1992-05-14 Allelix Biopharmaceuticals Inc. Peptide-based inhibitors of hiv replication
CA2094658A1 (en) * 1992-04-23 1993-10-24 Martin Sumner-Smith Intracellular delivery of biochemical agents
EP0599303A2 (en) * 1992-11-27 1994-06-01 Takeda Chemical Industries, Ltd. Peptide conjugate

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA209468A (en) * 1921-03-15 Mitchell William Stocking
US4053638A (en) * 1970-05-06 1977-10-11 William Wrigley Jr. Company Anticaries confectioneries and oral health products
US3915800A (en) * 1972-03-30 1975-10-28 Kelco Co Polysaccharide and bacterial fermentation process for its preparation
US4083974A (en) * 1977-03-07 1978-04-11 The Upjohn Company Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
US4847240A (en) 1978-01-16 1989-07-11 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US4701521A (en) 1978-07-17 1987-10-20 The Trustees Of Boston University Method of effecting cellular uptake of molecules
JPS55500053A (en) 1978-01-16 1980-01-31
US4631190A (en) 1981-06-26 1986-12-23 Shen Wei C Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers
US4880911A (en) 1982-03-19 1989-11-14 G. D. Searle & Co. Fused polypeptides and methods for their detection
US4532207A (en) 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4883661A (en) * 1987-10-09 1989-11-28 Daly John M Use of arginine as an lymphokine synergist
JP2804273B2 (en) * 1988-03-09 1998-09-24 株式会社メニコン Highly hydrous ophthalmic lens material
US5241078A (en) * 1988-06-14 1993-08-31 Cetus Oncology Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5162505A (en) 1989-09-19 1992-11-10 Centocor Proteins modified with positively charged carriers and compositions prepared therefrom
ES2091916T3 (en) 1989-12-21 1996-11-16 Whitehead Biomedical Inst METHOD FOR SUPPLYING MOLECULES INSIDE EUCARIOTIC CELLS.
US5576351A (en) * 1989-12-29 1996-11-19 Mcgaw, Inc. Use of arginine as an immunostimulator
US5115075A (en) * 1990-05-08 1992-05-19 The Dow Chemical Company Amide and hydroxymethyl functionalized polyethers as thermoplastic barrier resins
US5409764A (en) * 1990-07-17 1995-04-25 Toyo Ink Manufacturing Co., Ltd. Curable adhesive composition and sheet thereof
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
US5646120A (en) 1990-10-24 1997-07-08 Allelix Biopharmaceuticals, Inc. Peptide-based inhibitors of HIV replication
US5633230A (en) 1990-10-24 1997-05-27 Allelix Biopharmaceuticals, Inc. Treatment of cytomegalovirus infection
US5674849A (en) 1990-10-24 1997-10-07 Allelix Biopharmaceuticals Inc. Anti-viral compositions
US5831001A (en) 1990-10-24 1998-11-03 Allelix Biopharmaceuticals Inc. Treatment of herpesvirus infection
CA2116107A1 (en) 1991-09-05 1993-03-18 George Y. Wu Targeted delivery of poly-or oligonucleotides to cells
ATE169822T1 (en) 1992-04-23 1998-09-15 Allelix Biopharma TREATMENT OF HERPESVIRUS INFECTION
US5434257A (en) * 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
JP2702285B2 (en) 1992-08-21 1998-01-21 バイオジェン，インコーポレイテッド TAT-derived transport polypeptide
CA2152387C (en) 1992-12-22 1998-10-27 Michael Twist (Deceased) Synergistic anti-viral compositions
CA2152373C (en) 1993-10-22 1998-12-15 Michael Twist (Deceased) Treatment of cytomegalovirus infection
US5716614A (en) 1994-08-05 1998-02-10 Molecular/Structural Biotechnologies, Inc. Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
US5783178A (en) * 1994-11-18 1998-07-21 Supratek Pharma. Inc. Polymer linked biological agents
WO1996021036A2 (en) 1994-12-30 1996-07-11 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity
ZA962455B (en) * 1995-03-31 1996-10-02 B Eugene Guthery Fast acting and persistent topical antiseptic
NZ332234A (en) 1996-03-12 2000-06-23 Pg Txl Company Lp Water soluble paclitaxel prodrugs formed by conjugating paclitaxel or docetaxel with a polyglutamic acid polymer and use for treating cancer
EP0966303A2 (en) 1996-05-01 1999-12-29 Antivirals Inc. Polypeptide conjugates for transporting substances across cell membranes
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5842441A (en) * 1996-08-26 1998-12-01 Pharmalett Denmark A/S Medicated and individualized treatment shampoo for dermatological disturbances of companion animals
ATE251913T1 (en) * 1997-05-21 2003-11-15 Univ Leland Stanford Junior COMPOSITION AND METHOD FOR DELAYING TRANSPORT THROUGH BIOLOGICAL MEMBRANES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007871A1 (en) * 1990-10-24 1992-05-14 Allelix Biopharmaceuticals Inc. Peptide-based inhibitors of hiv replication
CA2094658A1 (en) * 1992-04-23 1993-10-24 Martin Sumner-Smith Intracellular delivery of biochemical agents
EP0599303A2 (en) * 1992-11-27 1994-06-01 Takeda Chemical Industries, Ltd. Peptide conjugate

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BURTON, K. A. ET AL: "Basic polyelectrolytes and protein transport across the newborn pig intestine", J. PHYSIOL., 1970, VOL. 211, NO. 2, PAGE(S) 27P-28P, XP002086014 *
BUSCHLE M. ET AL: "Transloading of tumor antigen-derived peptides into antigen-presenting cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, VOL. 94, NO. 7, PAGE(S) 3256-3261, XP002086009 *
CHEMICAL ABSTRACTS, vol. 123, no. 7, 1995, Columbus, Ohio, US; abstract no. 79357, SUMNER-SMITH, M. ET AL: "Antiherpetic activities of N-.alpha.-acetyl-nona-D-arginine amide acetate" XP002086015 *
DRUGS EXP. CLIN. RES., 1995, VOL. 21, NO. 1, PAGE(S) 1-6 *
ELFERINK JG: "Changes of plasma membrane permeability in neutrophils treated with polycations.", INFLAMMATION, APR 1991, VOL. 15, NO. 2, PAGE(S) 103-15, XP002086012 *
MAUERSBERGER B ET AL: "Studies on the cytotoxicity of poly-L-arginine, poly -L-lysine and DEAE-dextran in L-cells and mouse embryonic fibroblasts.", EXP PATHOL (JENA), 1977, VOL. 13, NO. 4-5, PAGE(S) 268-73, XP002086013 *
NATSUME, H. ET AL: "Screening of absorption enhancers for nasal peptide and protein delivery", 23RD. PROC. INT. SYMP. CONTROLLED RELEASE BIOACT. MATER.,JULY 7-10, 1996 PAGES 481-482, XP002086011 *
UCHIDA D. ET AL: "Polycations decrease the transepithelial resistance of cultured tracheal epithelial cells", CHEST, 1992, VOL. 101, NO. 3 (SUPPL.), PAGE(S) 33S, XP002086010 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974774B2 (en) 2004-03-03 2015-03-10 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport

Also Published As

Publication number Publication date
GB9923841D0 (en) 1999-12-08
DE69818987D1 (en) 2003-11-20
JP2002502376A (en) 2002-01-22
PL337033A1 (en) 2000-07-31
DE69818987T2 (en) 2004-07-29
EP0975370A2 (en) 2000-02-02
ES2210761T3 (en) 2004-07-01
CN1263473A (en) 2000-08-16
US20030162719A1 (en) 2003-08-28
US6306993B1 (en) 2001-10-23
KR20010012809A (en) 2001-02-26
BR9809138A (en) 2001-08-28
US20060111274A1 (en) 2006-05-25
GB2341390A (en) 2000-03-15
AU7593898A (en) 1998-12-11
AU734827B2 (en) 2001-06-21
US6495663B1 (en) 2002-12-17
ATE251913T1 (en) 2003-11-15
CA2291074C (en) 2008-04-01
CA2291074A1 (en) 1998-11-26
EP0975370B9 (en) 2004-11-03
US20020131965A1 (en) 2002-09-19
IL132941A0 (en) 2001-03-19
WO1998052614A2 (en) 1998-11-26
EP0975370B1 (en) 2003-10-15
GB2341390B (en) 2000-11-08

Similar Documents

Publication Publication Date Title
WO1998052614A3 (en) Composition and method for enhancing transport across biological membranes
WO2002065986A3 (en) Transporters comprising spaced arginine moieties
EP2266590A3 (en) Active agent delivery sytems and methods for protecting and administering active agents
PL334365A1 (en) Stable liquid inteferon formulations
WO1994017099A3 (en) BIOLOGICALLY ACTIVE TGF-β1 AND TGF-β2 PEPTIDES
WO1993025583A3 (en) Proteinoid carriers and methods for preparation and use thereof
EP1025840A3 (en) Oral drug compositions and methods
WO1998007745A3 (en) Compositions and methods for treating infections using analogues of indolicidin
ATE283034T1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING FACTOR VIII AND NEUTRAL LIPOSOMES
EP1262527A3 (en) Antistatic polymer compositions
AU1278000A (en) Particles based on polyamino-acid(s) and methods for preparing same
EP0528312A3 (en) Cyclic peptides and use thereof
EP0378641A4 (en) Novel antimicrobial peptide, compositions containing same and uses thereof
CA2935888A1 (en) Peptide dendrimers comprising fibrinogen-binding peptides
WO1995003327A3 (en) Peptides for neutralizing the toxicity of lipid a
Sedlačík et al. Enzymatic degradation of the hydrogels based on synthetic poly (α-amino acid) s
FR2846883B1 (en) COSMETIC COMPOSITION COMPRISING, AS ACTIVE INGREDIENT, AT LEAST ONE PEPTIDE AND USE OF THIS PEPTIDE
BR9809103A (en) Stable pharmaceutical form of administration for peptides, proteins and nucleic acids
JPS5594934A (en) Peptide type polymer and pharmaceutic composition containing it
WO1996028468A3 (en) Amphiphilic peptide and analogs thereof
EP0354714A3 (en) Pharmaceutical compositions containing polyaromatic compounds
KR890013061A (en) Polypeptide derivatives
De Marre et al. Synthesis of macromolecular Mitomycin C derivatives
EP1174439A3 (en) Compositions and methods for treating infections using analogues of indolicidin
ATE331533T1 (en) PHARMACEUTICAL COMPOSITIONS OF HEDGEHOG PROTEINS AND THEIR USE

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 132941

Country of ref document: IL

Ref document number: 98807186.X

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998923711

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 9923841

Country of ref document: GB

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PV1999-4066

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: PA/a/1999/010704

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1019997010772

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2291074

Country of ref document: CA

Ref document number: 2291074

Country of ref document: CA

Kind code of ref document: A

Ref document number: 1998 550716

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 75938/98

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1998923711

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV1999-4066

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1019997010772

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV1999-4066

Country of ref document: CZ

WWG Wipo information: grant in national office

Ref document number: 75938/98

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: 1019997010772

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 1998923711

Country of ref document: EP