WO1999017663A1 - Device and method for delivering fiber into a body - Google Patents

Device and method for delivering fiber into a body Download PDF

Info

Publication number
WO1999017663A1
WO1999017663A1 PCT/US1998/020371 US9820371W WO9917663A1 WO 1999017663 A1 WO1999017663 A1 WO 1999017663A1 US 9820371 W US9820371 W US 9820371W WO 9917663 A1 WO9917663 A1 WO 9917663A1
Authority
WO
WIPO (PCT)
Prior art keywords
tubular member
fiber material
fiber
opening
lumen
Prior art date
Application number
PCT/US1998/020371
Other languages
French (fr)
Inventor
Josef Slanda
David Sauvageau
Barry N. Gellman
Armand Morin
Original Assignee
Boston Scientific Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Corporation filed Critical Boston Scientific Corporation
Priority to EP98949605A priority Critical patent/EP1018949B1/en
Priority to CA002304663A priority patent/CA2304663C/en
Priority to JP2000514566A priority patent/JP4065663B2/en
Priority to IL13536198A priority patent/IL135361A0/en
Priority to AU95895/98A priority patent/AU734010B2/en
Priority to DE69831342T priority patent/DE69831342T2/en
Publication of WO1999017663A1 publication Critical patent/WO1999017663A1/en
Priority to IL135361A priority patent/IL135361A/en
Priority to IL184833A priority patent/IL184833A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0483—Hand-held instruments for holding sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06066—Needles, e.g. needle tip configurations
    • A61B17/06109—Big needles, either gripped by hand or connectable to a handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/008—Implant devices for drainage of body fluids from one part of the body to another pre-shaped, for use in the urethral or ureteral tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0482—Needle or suture guides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/31581—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle

Definitions

  • fiber material e.g., a fiber thread or a fiber pellet
  • devices and methods according to the invention are used to deliver the fiber material to radial sites about the urethra, and the fiber material provides bulking of tissue around the urethra to enable the patient to be continent permanently. That is, placing the fiber material at radial sites about the urethra forces coaptation of this valve and thus enables the patient to be continent permanently.
  • the invention involves a device for introducing fiber material into a body.
  • the device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member.
  • the device also comprises a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body.
  • the invention relates to a device for introducing fiber material into a body.
  • the device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member, and a helical member within the tubular member for conveying the fiber material through at least a portion of the lumen, out of the opening, and into the body.
  • a syringe can be coupled to the tubular member in communication with the lumen, and the syringe can provide the fiber material into the lumen of the tubular member.
  • the fiber material can comprise particles in a carrier such as a gel or liquid carrier.
  • the invention features a device for introducing fiber material into a body.
  • the device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member, and a sleeve slidable within the tubular member for forcing the fiber material through at least a portion of the lumen, out of the opening, and into the body.
  • a driving roller can feed the fiber material into a distal portion of the tubular member until the fiber material accumulates inside the distal portion, and then the sleeve can be moved to force the accumulated fiber material out of the opening in the distal end portion of the tubular member and into the body.
  • the fiber material can comprise a suture or a thread.
  • the invention in still another aspect, involves a device for introducing fiber material into a body.
  • the device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member, and a push rod slidable within the tubular member for pushing the fiber material through at least a portion of the lumen, out of the opening, and into the body.
  • the fiber material can comprise one or more pellets.
  • the invention in yet still another aspect, relates to a method of introducing fiber material into a body.
  • the method comprises providing a device including (i) a tubular member having a lumen extending to an opening in a distal end portion of the tubular member and (ii) a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body.
  • the method further comprises introducing the tubular member of the device into the body, and operating the mechanism in the tubular member of the device to pass the fiber material through the opening in the distal end portion of the tubular member and into the body.
  • FIG. 1 is a perspective view of a first embodiment of a material delivery device in accordance with the invention with portions of the device removed to reveal internal components of the device.
  • FIG. 2 is a perspective view of a second embodiment of the device.
  • FIG. 4 is a cross sectional view of particular components of the device of FIG. 2.
  • FIG. 5a is a top view of a housing of the device of FIG. 2.
  • FIG. 5b is a cross sectional view of the housing of FIG. 5a.
  • FIG. 5c is a cross sectional view of the housing of FIG. 5a.
  • FIG. 9a is a bottom view of an advancing lever shown in FIG. 2.
  • FIG. 1 la is a cross sectional view of a driving knob shown in FIG. 2.
  • FIG. 13a is a perspective view of a third embodiment of the device.
  • FIGS. 13b and 13c are cross sectional views of the device of FIG. 13a.
  • FIG. 14a is a top view of a housing shown in FIG. 13a.
  • FIG. 14d is a rear view of the housing of FIG. 14a.
  • FIG. 15a is a bottom view of an advancing lever shown in FIG. 13a.
  • FIG. 15b is a side view of the advancing lever of FIG. 13 a.
  • FIG. 16a is a rear view of a pivot arm shown in FIG. 13a.
  • FIG. 17b is a side view of the coupler of FIG. 17a.
  • FIG. 18 shows three layers of fiber wound on a mandrel to form a fiber pellet for loading in one of the devices.
  • FIG. 19 shows two layers of fiber wound on a mandrel to form a fiber pellet for loading in one of the devices.
  • FIG. 20 shows structure for winding the fiber on the mandrel to form a pellet.
  • FIG. 21 shows a way in which a fiber pellet is loaded in one of the devices.
  • FIG. 22 shows a way in which the fiber pellet is loaded in the devices.
  • FIG. 23 is a view of a push rod advancing apparatus for use with a fourth embodiment of the invention.
  • FIG. 24 is a side view of a needle for mounting to the device of FIG. 23.
  • FIG. 25 is a view of tubular cartridge loaded with a fiber pellet.
  • FIG. 26 is a view showing how the fiber pellet in the cartridge of FIG. 25 is loaded in the needle of FIG. 24.
  • FIG. 27 is a view showing the needle of FIG. 24 mounted to the advancing apparatus of FIG. 23 to deliver the fiber pellet.
  • FIG. 28 is a perspective view of a fifth embodiment of the device.
  • the present invention is directed to a device for delivering a fiber through a tubular member, such as a hypodermic needle.
  • the term fiber or fiber material includes one or more fiber strands, suture material, or thread material, for example.
  • the fiber is preferably made of material comprising polypropylene, nylon, polyester, silk, and/or cross linked polysaccharide, such as calcium alginate.
  • the fiber is preferably polypropylene suture, polyester suture, calcium alginate thread, or silk suture.
  • the fiber alternatively includes polyester, polypropylene, silk and/or calcium alginate fibrous material having a length or diameter of about 100 microns to about 200 microns.
  • the device is capable of delivering the fiber material to radial sites about the urethra.
  • the fiber material provides bulking of tissue around the urethra, thus enabling the patient to be permanently continent.
  • FIG. 1 shows a first embodiment of a device 10 for delivering the fiber.
  • the device 10 includes a syringe 12 coupled to a tubular member 14 via a Y-shaped luer adapter 32.
  • the syringe 12 includes a slidable plunger and a barrel filled with the fiber.
  • the barrel of the syringe 12 contains other materials or particles for delivery into the body and for bulking of tissue.
  • the tubular member 14 is preferably a needle or tube having a gauge of about 16 and a length of about 10 inches.
  • the tubular member 14 is joined to the adapter 32 with an adhesive.
  • a helical member 16 is provided in a lumen of the tubular member
  • the helical member 16 is shaped like an impeller, corkscrew, or auger. Rotation of a driving knob 24 rotates the helical member 16 in the lumen of the tubular member 14 so that the helical member 16 conveys bulking material (fiber) along the length of the tubular member 14 and through an opening in a distal portion of the tubular member 14.
  • a brazed connection 30 joins the helical member 16 to a mandrel 18, and the mandrel 18 is connected to the driving knob 24 via a set screw 22.
  • a tubular housing 20 for the mandrel 18 has a distal end connected to a leg of the adapter 32.
  • a driving lock 26 threaded on a proximal portion of the tubular housing 20 is rotatable to prevent (or provide resistance to) rotation of the driving knob 24.
  • An o-ring seal 28 maintains a seal between the tubular housing 20 and the rotatable mandrel 18.
  • the tubular member 14 is inserted in the body.
  • the plunger of the syringe 12 is pressed to pass material from the syringe 12 to the tubular member 14.
  • the driving knob 24 is rotated to rotate the helical member 16 and thereby convey the material through both the tubular member 14 and the opening in the tubular member 14.
  • the device 100 also includes an adjustable tension screw 128 shown in FIGS. 2 and 3 for adjusting the distance between the outer surface of the driving roller 120 and an inner surface of the hollow guide 132. Adjustment of the tension screw 128 controls the degree of slippage between the outer surface of the driving roller 120 and the fiber F. This allows the device 110 to accommodate a number of different sizes of fiber F.
  • the outer surface of the driving roller 120 is designed to reduce slippage of the fiber F.
  • the device 100 also includes an advancing lever 112 having an end portion pivotally connected to the housing 110.
  • a pivot arm 114 shown in FIGS. 2-4, 6a, and 6b has a first end pivotally connected to the advancing lever 112 and a second end pivotally connected to the coupler 126. Pivoting of the advancing lever 112 with respect to the housing 110 transmits motion to the pivot arm 114 and coupler 126 to move the sleeve 130 about its axis. In other words, pivoting of the advancing lever 112 slides sleeve 130 distally or proximally in the tubular member 14a depending upon the direction of pivoting of the advancing lever 112. With reference to FIG.
  • FIGS. 13a, 13b, 13c, 14a, 14b, 14c, 14d, 15a, 15b, 16a, 16b, 16c, 17a, and 17b show a third embodiment of a device 200 for introducing fiber in the body.
  • the device 200 includes a housing 210 having a passage extending along its length.
  • a tubular member 14b shown in FIGS. 13a and 13b has a proximal end connected to a distal end of the housing 210.
  • the tubular member 14b is a tube or needle releasably coupled to the housing 210.
  • an inner lumen of the tubular member 14b is preferably loaded with one or more pellets P of fiber, described below.
  • the tubular member 146 contains a plurality of pellets P, for example, ten.
  • the pellet P is loaded in a tubular member of a device for introducing the pellet P.
  • FIG. 21 shows one example of how the pellet P is loaded in a tubular member 14c, such as a tube or needle.
  • the pellet P is inserted in a lumen of the tubular member 14c and the mandrel 310 is removed from the pellet P.
  • additional pellets P are inserted in the tubular member 14c in the same manner.
  • a tubular member 14e shown in FIGS. 24, 26, and 27 has a threaded luer adapter 520 capable of being connected to the luer adapter 518 on the syringe barrel 514, as shown in FIG. 27.
  • tubular member 14e is a tube or needle, and the luer adapter 520 on the tubular member 14e is capable of being connected to a cystoscope for use in imaging the urethra.
  • the tubular member 14e is preferably loaded with one or more of the fiber pellets P.
  • the tubular member 14e is preferably loaded with the fiber pellet(s) P in the same way in which the tubular member 14d shown in FIG. 22 is loaded with pellet(s) P.
  • one or more of the pellets P are pushed into the tubular member 14e from a cartridge 440 shown in FIGS. 25 and 26 by a pushing member 450. After one or more pellets P are loaded in the tubular member 14e and the tubular member
  • FIG. 28 shows another device 600 for introducing fiber into the body.
  • the device 600 includes a housing 610 and a tubular member 14f connected to the housing 600.
  • the tubular member 14f is a needle or tube releasably connected of the housing 610.
  • the tubular member 14f is preferably loaded with a plurality of the pellets P.
  • a slide 620 is movable in a proximal end portion of the housing 610.
  • a push rod 630 extends through a passage in the slide 620 and into the tubular member 14f.
  • the slide 620 has a unidirectional engagement mechanism 636 including a pair of pivoting cams 632.
  • fiber pellets P are loaded in the tubular member 14f and the tubular member 14f is connected to the housing 610.
  • the tubular member 14f is inserted in the body and the slide 620 is moved in the distal direction with respect to the housing 610.
  • the unidirectional engagement mechanism 636 engages an outer surface of the push rod 630 and the one-way clutch mechanism 640 is placed out of engagement with the push rod 630. This allows the push rod 630 to move in the distal direction along with the slide 620.
  • the distal end of the push rod 630 pushes one or more fiber pellets P through the opening in the tubular member 14f.
  • the return spring 650 moves the slide 620 proximally back to its original position.

Abstract

A device, and related method, for introducing fiber material into a body includes a tubular member with a lumen extending to an opening in a distal end portion of the tubular member and a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body. The mechanism can be a helical member rotatable within the tubular member to convey the fiber material through at least a portion of the lumen, out of the opening, and into the body, and the fiber material can be particles in a carrier that are injected into the lumen by a syringe coupled to the tubular member. The mechanism alternatively can be a sleeve slidable within the tubular member to force the fiber material through at least a portion of the lumen, out of the opening, and into the body, and the fiber material can be a suture or thread that is fed into a distal portion of the tubular member where it collects until it is forced out of the opening by the sleeve. The mechanism also can be a push rod slidable within the tubular member to push the fiber material through at least a portion of the lumen, out of the opening, and into the body, and the fiber material can be one or more pellets.

Description

DEVICE AND METHOD FOR DELIVERING FIBER INTO A BODY
Cross-Reference to Related Application
This incorporates by reference and claims priority to and the benefit of U.S. provisional patent application serial number 60/060,842 which was filed on October 2, 1997.
Technical Field This invention relates to a device for delivering material into the body and a method of using such a device. More particularly, the present invention relates to feeding a fiber or particles through a tubular member, such as a needle.
Background Information Many different types of medical and surgical treatments require a mass of material to be implanted in the body. For example, in one type of procedure for treating urinary incontinence, material is delivered to radial sites about the urethra to bulk tissue around the urethra. In other procedures, materials, such as bulking materials, are implanted in the body to treat aneurysms and arteriovenous malformations (AVMs), for example.
One type of bulking material currently approved by the FDA is a mixture of a phosphate carrier and either collagen or fat. However, this type of material is absorbed in the body within about one year and sometimes needs to be reinjected into a patient periodically. Other materials, such as TEFLON and silicone, have been tested, but some of these materials may be capable of migrating to vital organs of the body, such as the brain or the lungs, and thereby harm a patient.
Summary of the Invention The invention relates to the use of fiber materials, such as threads and sutures, in bulking tissue. These fiber materials provide a permanent bulking, and are not absorbed in or by the body. The fiber materials can be made of the same substances used to form surgical sutures and wound care products that have a long, successful, and safe history when used for patient implantation.
It is an object of the invention to provide devices and methods for delivering fiber materials into the body for a variety of different uses. It is another object to provide devices and methods for dispensing fiber material (e.g., a fiber thread or a fiber pellet) into a body to bulk tissue to, for example, treat urinary incontinence. In treating urinary incontinence, devices and methods according to the invention are used to deliver the fiber material to radial sites about the urethra, and the fiber material provides bulking of tissue around the urethra to enable the patient to be continent permanently. That is, placing the fiber material at radial sites about the urethra forces coaptation of this valve and thus enables the patient to be continent permanently.
It is a further object to provide devices and methods for directing the fiber material into a patient's body with sufficient force to maintain long-term bulking of tissue with the fiber material.
In one aspect, the invention involves a device for introducing fiber material into a body. The device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member. The device also comprises a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body. In another aspect, the invention relates to a device for introducing fiber material into a body. The device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member, and a helical member within the tubular member for conveying the fiber material through at least a portion of the lumen, out of the opening, and into the body. A syringe can be coupled to the tubular member in communication with the lumen, and the syringe can provide the fiber material into the lumen of the tubular member. The fiber material can comprise particles in a carrier such as a gel or liquid carrier.
In yet another aspect, the invention features a device for introducing fiber material into a body. The device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member, and a sleeve slidable within the tubular member for forcing the fiber material through at least a portion of the lumen, out of the opening, and into the body. A driving roller can feed the fiber material into a distal portion of the tubular member until the fiber material accumulates inside the distal portion, and then the sleeve can be moved to force the accumulated fiber material out of the opening in the distal end portion of the tubular member and into the body. The fiber material can comprise a suture or a thread. In still another aspect, the invention involves a device for introducing fiber material into a body. The device comprises a tubular member having a lumen extending to an opening in a distal end portion of the tubular member, and a push rod slidable within the tubular member for pushing the fiber material through at least a portion of the lumen, out of the opening, and into the body. The fiber material can comprise one or more pellets.
In yet still another aspect, the invention relates to a method of introducing fiber material into a body. The method comprises providing a device including (i) a tubular member having a lumen extending to an opening in a distal end portion of the tubular member and (ii) a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body. The method further comprises introducing the tubular member of the device into the body, and operating the mechanism in the tubular member of the device to pass the fiber material through the opening in the distal end portion of the tubular member and into the body.
The foregoing and other objects, aspects, features, and advantages of the invention will become more apparent from the following description and from the claims.
Brief Description of the Drawings In the drawings, like reference characters generally refer to the same parts throughout the different views. Also, the drawings are not necessarily to scale, emphasis instead generally being placed upon illustrating the principles of the invention.
FIG. 1 is a perspective view of a first embodiment of a material delivery device in accordance with the invention with portions of the device removed to reveal internal components of the device. FIG. 2 is a perspective view of a second embodiment of the device.
FIG. 3 is a cross sectional view of the device of FIG. 2.
FIG. 4 is a cross sectional view of particular components of the device of FIG. 2. FIG. 5a is a top view of a housing of the device of FIG. 2. FIG. 5b is a cross sectional view of the housing of FIG. 5a. FIG. 5c is a cross sectional view of the housing of FIG. 5a.
FIG. 6a is a rear view of a pivot arm shown in FIG. 2. FIG. 6b is a side view of the pivot arm of FIG. 6a. FIG. 7a is a front view of a coupler shown in FIG. 3. FIG. 7b is a side view of the coupler of FIG. 7a. FIG. 7c is a top view of the coupler of FIG. 7a.
FIG. 8a is a side view of a roller mount shown in FIG. 3. FIG. 8b is a front view of the roller mount of FIG. 8a.
FIG. 8c is a top view of the roller mount of FIG. 8a.
FIG. 9a is a bottom view of an advancing lever shown in FIG. 2.
FIG. 9b is a side view of the advancing lever of FIG. 9a.
FIG. 10a is a cross sectional view of a drive roller shown in FIGS. 3 and 4.
FIG. 10b is a front view of the drive roller of FIG. 10a.
FIG. 1 la is a cross sectional view of a driving knob shown in FIG. 2.
FIG. l ib is a side view of the driving knob of FIG. 11a.
FIG. 12a is a cross sectional view of a drive mechanism cover shown in FIG. 2.
FIG. 12b is a side view of the drive mechanism cover of FIG. 12a.
FIG. 13a is a perspective view of a third embodiment of the device.
FIGS. 13b and 13c are cross sectional views of the device of FIG. 13a.
FIG. 14a is a top view of a housing shown in FIG. 13a.
FIGS. 14b and 14c are cross sectional views of the housing of FIG. 14a.
FIG. 14d is a rear view of the housing of FIG. 14a.
FIG. 15a is a bottom view of an advancing lever shown in FIG. 13a.
FIG. 15b is a side view of the advancing lever of FIG. 13 a.
FIG. 16a is a rear view of a pivot arm shown in FIG. 13a.
FIG. 16b is a side view of the pivot arm of FIG. 16a.
FIG. 17a is a front view of a coupler shown in FIG. 13a.
FIG. 17b is a side view of the coupler of FIG. 17a.
FIG. 17c is a top view of the coupler of FIG. 17a.
FIG. 18 shows three layers of fiber wound on a mandrel to form a fiber pellet for loading in one of the devices.
FIG. 19 shows two layers of fiber wound on a mandrel to form a fiber pellet for loading in one of the devices.
FIG. 20 shows structure for winding the fiber on the mandrel to form a pellet.
FIG. 21 shows a way in which a fiber pellet is loaded in one of the devices.
FIG. 22 shows a way in which the fiber pellet is loaded in the devices.
FIG. 23 is a view of a push rod advancing apparatus for use with a fourth embodiment of the invention.
FIG. 24 is a side view of a needle for mounting to the device of FIG. 23. FIG. 25 is a view of tubular cartridge loaded with a fiber pellet.
FIG. 26 is a view showing how the fiber pellet in the cartridge of FIG. 25 is loaded in the needle of FIG. 24.
FIG. 27 is a view showing the needle of FIG. 24 mounted to the advancing apparatus of FIG. 23 to deliver the fiber pellet.
FIG. 28 is a perspective view of a fifth embodiment of the device.
Description The present invention is directed to a device for delivering a fiber through a tubular member, such as a hypodermic needle. As used herein, the term fiber or fiber material includes one or more fiber strands, suture material, or thread material, for example. The fiber is preferably made of material comprising polypropylene, nylon, polyester, silk, and/or cross linked polysaccharide, such as calcium alginate. For example, the fiber is preferably polypropylene suture, polyester suture, calcium alginate thread, or silk suture. In addition, the fiber alternatively includes polyester, polypropylene, silk and/or calcium alginate fibrous material having a length or diameter of about 100 microns to about 200 microns.
Preferably, the device is capable of delivering the fiber material to radial sites about the urethra. The fiber material provides bulking of tissue around the urethra, thus enabling the patient to be permanently continent.
Preferably, the device does not use a carrier, such as saline solution or phosphate solution, to carry the fiber and to open the tissue planes. The device is preferably capable of directing the fiber into the body with a sufficient force to maintain long-term bulking of tissue. FIG. 1 shows a first embodiment of a device 10 for delivering the fiber. The device 10 includes a syringe 12 coupled to a tubular member 14 via a Y-shaped luer adapter 32. The syringe 12 includes a slidable plunger and a barrel filled with the fiber. Alternatively, the barrel of the syringe 12 contains other materials or particles for delivery into the body and for bulking of tissue. When the plunger of the syringe 12 is pressed, the material in the barrel of the syringe 12 passes into the tubular member 14. The tubular member 14 is preferably a needle or tube having a gauge of about 16 and a length of about 10 inches. Optionally, the tubular member 14 is joined to the adapter 32 with an adhesive. As shown in FIG. 1, a helical member 16 is provided in a lumen of the tubular member
14. The helical member 16 is shaped like an impeller, corkscrew, or auger. Rotation of a driving knob 24 rotates the helical member 16 in the lumen of the tubular member 14 so that the helical member 16 conveys bulking material (fiber) along the length of the tubular member 14 and through an opening in a distal portion of the tubular member 14.
A brazed connection 30 joins the helical member 16 to a mandrel 18, and the mandrel 18 is connected to the driving knob 24 via a set screw 22. A tubular housing 20 for the mandrel 18 has a distal end connected to a leg of the adapter 32. A driving lock 26 threaded on a proximal portion of the tubular housing 20 is rotatable to prevent (or provide resistance to) rotation of the driving knob 24. An o-ring seal 28 maintains a seal between the tubular housing 20 and the rotatable mandrel 18. To use the device 10, the tubular member 14 is inserted in the body. The plunger of the syringe 12 is pressed to pass material from the syringe 12 to the tubular member 14. The driving knob 24 is rotated to rotate the helical member 16 and thereby convey the material through both the tubular member 14 and the opening in the tubular member 14.
The barrel of the syringe 12 may be filled with many different types of materials, such as suture material, flat textured yarn material, ground suture material, or ground fabric polyester material. Preferably, the syringe 12 contains a paste or compound like substance, such as particles in a gel or liquid carrier. In the alternative, the syringe 12 contains a mixture of chopped suture and compound.
FIGS. 2-4, 5a, 5b, 5c, 6a, 6b, 7a, 7b, 7c, 8a, 8b, 8c, 9a, 9b, 10a, 10b, 1 la, 1 lb, 12a, and 12b show a second embodiment of a device 100 for delivering fiber in the body. As shown in FIGS. 2-4, 5a, 5b, and 5c, the device 100 includes a housing 110 and a tubular member 14a coupled to the housing 110 at a proximal end of the tubular member 14a. Preferably, the tubular member 14a is a needle or tube connected directly to the housing 110. Alternatively, the tubular member 14a is releasably coupled to the housing 110 via an adapter (not shown). A hollow guide 132 shown in FIGS. 3 and 4 is connected to a proximal end portion of the housing 110 and extends into a proximal end of the tubular member 14a. The fiber F is capable of passing through the hollow guide 132. As shown in FIGS. 3, 4, 10a, and 10b, a rotatable driving roller 120 is provided for feeding the fiber F through the hollow guide 132. The driving roller 120 is rotatably mounted in a roller mount 124 shown in FIGS. 3, 8a, 8b, and 8c, and extends into the lumen of the hollow guide 132 via a slot in the hollow guide 132, as shown in FIG. 4. A driving knob 116, shown in FIGS. 2, 11a, and 1 lb, is coupled to the driving roller 120 so that rotation of the driving knob 116 rotates the driving roller 120. A drive mechanism cover 118 shown in FIGS. 2, 12a and 12b is mounted to the housing 110 to cover an opening in the housing 110 for accommodating the driving roller 120 and roller mount 124. The device 100 also includes an adjustable tension screw 128 shown in FIGS. 2 and 3 for adjusting the distance between the outer surface of the driving roller 120 and an inner surface of the hollow guide 132. Adjustment of the tension screw 128 controls the degree of slippage between the outer surface of the driving roller 120 and the fiber F. This allows the device 110 to accommodate a number of different sizes of fiber F. Preferably, the outer surface of the driving roller 120 is designed to reduce slippage of the fiber F.
As shown in FIG. 3, an axially movable sleeve 130 is positioned between an outer surface of the hollow guide 132 and an inner surface of a proximal portion of the tubular member 14a, and between an outer surface of the hollow guide 132 and a distal portion of the housing 110. A coupler 126 shown in FIGS. 3, 4, 7a, 7b, and 7c is connected to a proximal end of the movable sleeve 126.
As shown in FIGS. 2, 3, 9a, and 9b, the device 100 also includes an advancing lever 112 having an end portion pivotally connected to the housing 110. A pivot arm 114 shown in FIGS. 2-4, 6a, and 6b has a first end pivotally connected to the advancing lever 112 and a second end pivotally connected to the coupler 126. Pivoting of the advancing lever 112 with respect to the housing 110 transmits motion to the pivot arm 114 and coupler 126 to move the sleeve 130 about its axis. In other words, pivoting of the advancing lever 112 slides sleeve 130 distally or proximally in the tubular member 14a depending upon the direction of pivoting of the advancing lever 112. With reference to FIG. 3, counter clockwise pivoting of the advancing lever 112 with respect to the housing 110 moves the sleeve 130 distally, and clockwise pivoting of the advancing lever 112 moves the sleeve 130 proximally. Preferably, a spring 122 shown in FIGS. 2 and 3 has one end connected to the advancing lever 112 and another end connected to the pivot arm 114 to bias the advancing lever 1 12 in the clockwise direction after the lever 112 pivots in the counter clockwise direction. To use the embodiment of FIGS. 2-4, the tubular member 14a is inserted into the body.
The fiber material F is passed into an opening in a proximal end of the guiding member 132. The driving roller 116 is rotated to rotate the driving roller 120 and thereby feed fiber F through the guiding member 132 and into the lumen of the tubular member 14a. When the fiber F encounters body tissue at the opening of the distal portion of the tubular member 14a, the fiber F bunches up inside the distal portion of the tubular member 14a. After a sufficient amount of fiber F accumulates in the distal portion of the tubular member 14a, an operator pivots the advancing lever 112 counter clockwise toward the housing 110 to move the sleeve 130 in the distal direction. The distal end of the sleeve 130 moves against the bunched fiber in the tubular member 14a to force this fiber mass from the distal opening of the tubular member 14a and into a body.
When an operator releases the advancing lever 112, the spring 122 biases the lever 112 away from the housing 110 and thereby moves the sleeve 130 in the proximal direction to its original position. During movement of the sleeve 130 in the proximal direction, the outer surface of the driving roller 120 maintains contact with the fiber F to resist proximal movement of fiber F in the device 110.
Preferably, the inner diameter of the tubular member 14a is large enough to allow a sufficient amount of the fiber material to bunch together. In addition, a space for the fiber F could be created using a balloon or some mechanical device. The device 110 also preferably includes structure (not shown) for cutting the fiber F to separate the bunch of fiber from the rest of the fiber. The fiber F can be a suture or a thread.
FIGS. 13a, 13b, 13c, 14a, 14b, 14c, 14d, 15a, 15b, 16a, 16b, 16c, 17a, and 17b show a third embodiment of a device 200 for introducing fiber in the body. As shown in FIGS. 13a, 13b, 13c, 14a, 14b, 14c, and 14d, the device 200 includes a housing 210 having a passage extending along its length. A tubular member 14b shown in FIGS. 13a and 13b has a proximal end connected to a distal end of the housing 210. Preferably, the tubular member 14b is a tube or needle releasably coupled to the housing 210. As shown in FIG. 13a, an inner lumen of the tubular member 14b is preferably loaded with one or more pellets P of fiber, described below. Preferably, the tubular member 146 contains a plurality of pellets P, for example, ten.
An axially movable push rod 220 shown in FIG. 13b extends in the longitudinal passage of the housing 210 and in the tubular member 14b. Similar to the embodiment of FIG. 2, the device 200 includes an advancing lever 212 (shown in FIGS. 13a, 13b, 15a, and 15b) pivotally connected to the housing 210, a coupler 216 (shown in FIGS. 17a, 17b, and 17c) connected to the push rod 220, a pivot arm 214 (shown in FIGS. 13a, 13b, 16a, and 16b) having one end pivotally connected to the advancing lever 212 and another end pivotally connected to the coupler 216, and a spring 218.
To use the device 200, the housing 210 is connected to the tubular member 14b loaded with one or more fiber pellets P and the tubular member 14b is inserted in the body. When the advancing lever 212 is pivoted toward the housing 210, the push rod 220 moves in the distal direction in the housing 210 and tubular member 14b. The distal end of the push rod 220 pushes one or more of the pellets P through an opening in a distal end of the tubular member 14b and into the body. Thereafter, the spring 218 returns the advancing lever 212 and push rod 220 to their original positions. Optionally, the device 200 has unidirectional engagement mechanism (described below) and clutch mechanism (described below) for resisting proximal movement of the push rod when the advancing lever 212 returns to its original position. With such an arrangement, each depression of the advancing lever 212 moves the push rod 220 further in the distal direction so that more of the pellets P may be dispensed through the opening in the tubular member 14b. FIG. 20 shows how the fiber pellet P is formed. A mandrel 310 is inserted into a pin vise
340 and an end portion of fiber F extending from a fiber spool 320 is secured to the pin vise 340. The pin vise 340 is rotated to wrap the fiber F helically around the mandrel 310. When a single layer of fiber F builds up on the mandrel 310, other layers are optionally wound on the initial layer. FIG. 18 shows an example of a fiber pellet P having 3 layers of helically wound fiber, and FIG. 19 shows an example of a fiber pellet P having 2 layers of helically wound fiber. For example, the pellet P is preferably about 1 inch to about 2 inches in length and made of nylon suture material.
After the fiber pellet P is formed, the pellet P is loaded in a tubular member of a device for introducing the pellet P. FIG. 21 shows one example of how the pellet P is loaded in a tubular member 14c, such as a tube or needle. The pellet P is inserted in a lumen of the tubular member 14c and the mandrel 310 is removed from the pellet P. Optionally, additional pellets P are inserted in the tubular member 14c in the same manner.
FIG. 22 shows another example of how a pellet P is loaded in a tubular member 14d, such as a tube or needle. Initially, one or more pellets P are loaded in a cartridge 440 in the same way that the pellet P is inserted in the tubular member 14c shown in FIG. 21. Then the cartridge 440 is coupled to an adapter 410 on the proximal end of the tubular member 14d. A pushing member 450 is then used to push the pellet(s) P from the cartridge 440 into the tubular member 14d. FIGS. 23-27 show another device for delivering fiber into a body. As shown in FIG. 23, this embodiment includes a syringe 510 having a plunger 512 slidable in a barrel 514. A threaded luer adapter 518 is provided at the distal end of the barrel 514. A push rod 516 extends from a distal end of the plunger 512 and through a distal opening in the barrel 514. Movement of the plunger 512 in the barrel 514 moves the push rod 516 axially.
A tubular member 14e shown in FIGS. 24, 26, and 27 has a threaded luer adapter 520 capable of being connected to the luer adapter 518 on the syringe barrel 514, as shown in FIG. 27. Preferably, tubular member 14e is a tube or needle, and the luer adapter 520 on the tubular member 14e is capable of being connected to a cystoscope for use in imaging the urethra. As shown in FIG. 27, the tubular member 14e is preferably loaded with one or more of the fiber pellets P. The tubular member 14e is preferably loaded with the fiber pellet(s) P in the same way in which the tubular member 14d shown in FIG. 22 is loaded with pellet(s) P. In other words, one or more of the pellets P are pushed into the tubular member 14e from a cartridge 440 shown in FIGS. 25 and 26 by a pushing member 450. After one or more pellets P are loaded in the tubular member 14e and the tubular member
14e is connected to the barrel 514, the tubular member 14e is inserted in the body. An operator moves the plunger 512 in the distal direction to extend the push rod 516 in the tubular member 14e. The distal end of the push rod 516 pushes one or more of the pellets P from a distal end of the tubular member 14e and into the body via an opening in the tubular member 14e. If more pellets P need to be loaded into the tubular member 14e during a procedure, the syringe barrel 514 is removed from the tubular member 14e, optionally while the tubular member 14e is still inserted in the body. Thereafter, the pellets P are loaded with the structure shown in FIG. 26.
For example, the distance from the distal end of the tubular member 14e needle to its connector 520 is 14 inches, and the length of the push rod 516 is 15 inches.
FIG. 28 shows another device 600 for introducing fiber into the body. The device 600 includes a housing 610 and a tubular member 14f connected to the housing 600. Preferably, the tubular member 14f is a needle or tube releasably connected of the housing 610. In addition, the tubular member 14f is preferably loaded with a plurality of the pellets P. A slide 620 is movable in a proximal end portion of the housing 610. A push rod 630 extends through a passage in the slide 620 and into the tubular member 14f. The slide 620 has a unidirectional engagement mechanism 636 including a pair of pivoting cams 632. The unidirectional engagement mechanism 636 engages an outer surface of the push rod 630 when the slide 620 is moved in the distal direction, and disengages from the push rod 630 when the slide 620 moves in the proximal direction. In other words, the mechanism 636 may function in a manner similar to a cleat used on a sail boat. The device 600 also includes a return spring 650 and one-way clutch mechanism 640 having a clutch spring 642 and clutch pad 644. The return spring 650 forces the slide 620 in the proximal direction after the slide 620 moves in the distal direction. The one-way clutch mechanism 640 allows distal movement of the push rod 630 and resists proximal movement of the push rod 630. Movement of the slide 620 in the distal direction overcomes a biasing force of the clutch spring 642 and moves the clutch pad 644 out of engagement with the push rod 630. Proximal movement of the slide 620 allows the clutch spring 642 to place the clutch pad 644 into engagement with the push rod 630.
To use the device 600, fiber pellets P are loaded in the tubular member 14f and the tubular member 14f is connected to the housing 610. The tubular member 14f is inserted in the body and the slide 620 is moved in the distal direction with respect to the housing 610. The unidirectional engagement mechanism 636 engages an outer surface of the push rod 630 and the one-way clutch mechanism 640 is placed out of engagement with the push rod 630. This allows the push rod 630 to move in the distal direction along with the slide 620. The distal end of the push rod 630 pushes one or more fiber pellets P through the opening in the tubular member 14f. When the slide 620 is released, the return spring 650 moves the slide 620 proximally back to its original position. The unidirectional engagement mechanism 636 releases its engagement with an outer surface of the push rod 630 and the one-way clutch mechanism 640 engages with the push rod 630. This resists movement of the push rod 630 in the proximal direction. Repeated distal movement and release of the slide 620 advances the push rod 630 further toward the distal end of tubular member 14f and thereby allows for continued dispensing of fiber pellets P from the tubular member 14f without the need to reload the device 600.
Preferably, each of the devices mentioned above is used to dispense fiber or fiber pellets for bulking tissue. For example, these devices are preferably used to provide tissue bulking for treating incontinence.
Variations, modifications, and other implementations of what is described herein will occur to those of ordinary skill in the art without departing from the spirit and the scope of the invention as claimed. Accordingly, the invention is to be defined not by the preceding illustrative description but instead by the spirit and scope of the following claims.
What is claimed is:

Claims

Claims
L A device for introducing fiber material into a body, comprising: a tubular member having a lumen extending to an opening in a distal end portion of the tubular member; and a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body. 2. The device of claim 1 wherein the mechanism comprises a helical member rotatable within the tubular member to convey the fiber material through at least a portion of the lumen, out of the opening, and into the body. 3. The device of claim 2 further comprising a syringe coupled to the tubular member and in communication with the lumen the syringe for providing the fiber material into the lumen of the tubular member. 4. The device of claim 3 wherein the fiber material comprises particles in a carrier. 5. The device of claim 1 wherein the mechanism comprises a sleeve slidable within the tubular member to force the fiber material through at least a portion of the lumen, out of the opening, and into the body. 6. The device of claim 5 further comprising a driving roller for feeding the fiber material into a distal portion of the tubular member until the fiber material accumulates inside the distal portion such that the sleeve can be moved to force the accumulated fiber material out of the opening in the distal end portion of the tubular member and into the body. 7. The device of claim 6 wherein the fiber material comprises a suture. 8. The device of claim 1 wherein the mechanism comprises a push rod slidable within the tubular member to push the fiber material through at least a portion of the lumen, out of the opening, and into the body. 9. The device of claim 8 wherein the fiber material comprises one or more pellets. 10. A method of introducing fiber material into a body, comprising: providing a device including (i) a tubular member having a lumen extending to an opening in a distal end portion of the tubular member and (ii) a mechanism in the tubular member for passing the fiber material through the lumen and the opening and into the body; introducing the tubular member of the device into the body; and operating the mechanism in the tubular member of the device to pass the fiber material through the opening in the distal end portion of the tubular member and into the body.
PCT/US1998/020371 1997-10-02 1998-09-30 Device and method for delivering fiber into a body WO1999017663A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP98949605A EP1018949B1 (en) 1997-10-02 1998-09-30 Device for delivering fiber material into a body
CA002304663A CA2304663C (en) 1997-10-02 1998-09-30 Device and method for delivering fiber into a body
JP2000514566A JP4065663B2 (en) 1997-10-02 1998-09-30 Device for delivering fibers into the body
IL13536198A IL135361A0 (en) 1997-10-02 1998-09-30 Device and method for delivering fiber into a body
AU95895/98A AU734010B2 (en) 1997-10-02 1998-09-30 Device and method for delivering fiber into a body
DE69831342T DE69831342T2 (en) 1997-10-02 1998-09-30 DEVICE FOR INTRODUCING FIBER MATERIALS IN THE BODY
IL135361A IL135361A (en) 1997-10-02 2000-03-30 Device and method for delivering fiber into a body particularly by using a tubular member
IL184833A IL184833A0 (en) 1997-10-02 2007-07-25 Device and method for delivering fiber into a body, particularly by using a tubular member

Applications Claiming Priority (2)

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US6084297P 1997-10-02 1997-10-02
US60/060,842 1997-10-02

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EP (1) EP1018949B1 (en)
JP (1) JP4065663B2 (en)
AU (1) AU734010B2 (en)
CA (1) CA2304663C (en)
DE (1) DE69831342T2 (en)
IL (3) IL135361A0 (en)
WO (1) WO1999017663A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220294545A1 (en) * 2021-03-09 2022-09-15 Apple Inc. Multi-phase-level signaling to improve data bandwidth over lossy channels

Families Citing this family (452)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1003865E (en) 1997-08-15 2008-10-14 Pasteur Institut Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection
US8465412B2 (en) * 2001-01-12 2013-06-18 Michael Levy Uterine devices and method of use
US20060183973A1 (en) * 2001-01-12 2006-08-17 Kamrava Michael M Endoscopic devices and method of use
US6758806B2 (en) 2001-01-12 2004-07-06 Napoli, Llc Endoscopic devices and method of use
US6623422B2 (en) 2001-01-12 2003-09-23 Napoli, Llc Method and apparatus for assisted embryo implantation
WO2002067772A2 (en) * 2001-01-12 2002-09-06 Napoli, Llc. Intra-uterine devices and method of use
US20020188170A1 (en) * 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
US7311731B2 (en) * 2001-04-27 2007-12-25 Richard C. Satterfield Prevention of myocardial infarction induced ventricular expansion and remodeling
US7033314B2 (en) * 2002-01-11 2006-04-25 Fidelitycorp Limited Endoscopic devices and method of use
US8277411B2 (en) * 2002-01-31 2012-10-02 Boston Scientific Scimed, Inc. Needle device
EP1507572B1 (en) * 2002-05-17 2007-01-10 Tyco Healthcare Group Lp Wound closure material applicator
US6830010B2 (en) * 2002-10-22 2004-12-14 Heartland Premium Beef, Inc. Quality assurance program and method for meat production
US20070084897A1 (en) 2003-05-20 2007-04-19 Shelton Frederick E Iv Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
US8444658B2 (en) * 2003-07-07 2013-05-21 Andrew C. Kim Hydrodynamic suture passer
US7396351B2 (en) 2003-11-05 2008-07-08 Boston Scientific Scimed, Inc. Device and method for the delivery of viscous fluids in the body
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
US8215531B2 (en) 2004-07-28 2012-07-10 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a medical substance dispenser
WO2006021932A1 (en) 2004-08-27 2006-03-02 Koninklijke Philips Electronics, N.V. Electronically and remotely controlled pill and system for delivering at least one medicament
US7335155B2 (en) * 2004-09-14 2008-02-26 Boston Scientific Scimed, Inc. Unitary formulation delivery device
US7244270B2 (en) * 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
US20060058892A1 (en) * 2004-09-16 2006-03-16 Lesh Michael D Valved tissue augmentation implant
US7641688B2 (en) * 2004-09-16 2010-01-05 Evera Medical, Inc. Tissue augmentation device
US20060058891A1 (en) * 2004-09-16 2006-03-16 Lesh Michael D Transformable tissue bulking device
WO2006034077A1 (en) * 2004-09-16 2006-03-30 Juva Medical, Inc. Tissue augmentation device
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US7673783B2 (en) * 2005-11-04 2010-03-09 Ethicon Endo-Surgery, Inc. Surgical stapling instruments structured for delivery of medical agents
US20070106317A1 (en) 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US7753904B2 (en) 2006-01-31 2010-07-13 Ethicon Endo-Surgery, Inc. Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US20120292367A1 (en) 2006-01-31 2012-11-22 Ethicon Endo-Surgery, Inc. Robotically-controlled end effector
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US20110024477A1 (en) 2009-02-06 2011-02-03 Hall Steven G Driven Surgical Stapler Improvements
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US20110290856A1 (en) 2006-01-31 2011-12-01 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instrument with force-feedback capabilities
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US8708213B2 (en) 2006-01-31 2014-04-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US8322455B2 (en) 2006-06-27 2012-12-04 Ethicon Endo-Surgery, Inc. Manually driven surgical cutting and fastening instrument
CA2658548A1 (en) * 2006-07-25 2008-01-31 Jeffrey E. Yeung Spooled filament to repair tissue
US8348131B2 (en) 2006-09-29 2013-01-08 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with mechanical indicator to show levels of tissue compression
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US8540128B2 (en) 2007-01-11 2013-09-24 Ethicon Endo-Surgery, Inc. Surgical stapling device with a curved end effector
US8727197B2 (en) 2007-03-15 2014-05-20 Ethicon Endo-Surgery, Inc. Staple cartridge cavity configuration with cooperative surgical staple
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US7753245B2 (en) 2007-06-22 2010-07-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US20090198329A1 (en) 2008-02-01 2009-08-06 Kesten Randy J Breast implant with internal flow dampening
US20090198331A1 (en) * 2008-02-01 2009-08-06 Kesten Randy J Implantable prosthesis with open cell flow regulation
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
RU2493788C2 (en) 2008-02-14 2013-09-27 Этикон Эндо-Серджери, Инк. Surgical cutting and fixing instrument, which has radio-frequency electrodes
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US20130153641A1 (en) 2008-02-15 2013-06-20 Ethicon Endo-Surgery, Inc. Releasable layer of material and surgical end effector having the same
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US20100331827A1 (en) * 2008-02-18 2010-12-30 Koninklijke Philips Electronics N.V. Administration of drugs to a patient
EP2303361B1 (en) * 2008-06-19 2015-02-25 Medimetrics Personalized Drug Delivery B.V. Capsule for delivery of powder like medication in the gastro-intestinal tract
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US8210411B2 (en) 2008-09-23 2012-07-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
US8517239B2 (en) 2009-02-05 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising a magnetic element driver
CA2751664A1 (en) 2009-02-06 2010-08-12 Ethicon Endo-Surgery, Inc. Driven surgical stapler improvements
US8444036B2 (en) 2009-02-06 2013-05-21 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector
US8057483B2 (en) * 2009-02-14 2011-11-15 Ocular Transplantation Llc Subretinal implantation instrument
JP5681875B2 (en) 2009-04-07 2015-03-11 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ Modular oral ingestion drug supply capsule
US8480681B2 (en) 2009-05-21 2013-07-09 Christopher Jordan Pressured syringe for the injection of a viscous liquid through a cannulated surgical screw bone filler adapter
EP2461850B1 (en) 2009-08-03 2014-10-08 Emory University A device for targeting therapeutic agents
EP2464414B1 (en) 2009-08-12 2013-06-12 Medimetrics Personalized Drug Delivery B.V. Drug delivery device with compressible drug reservoir
US9498271B2 (en) * 2009-10-29 2016-11-22 Cook Medical Technologies Llc Coaxial needle cannula with distal spiral mixer and side ports for fluid injection
EP2559402B1 (en) 2009-12-01 2016-05-04 Altura Medical, Inc. Modular endograft devices
US8851354B2 (en) 2009-12-24 2014-10-07 Ethicon Endo-Surgery, Inc. Surgical cutting instrument that analyzes tissue thickness
US8220688B2 (en) 2009-12-24 2012-07-17 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument with electric actuator directional control assembly
US8783543B2 (en) 2010-07-30 2014-07-22 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
WO2012040240A1 (en) 2010-09-20 2012-03-29 Altura Medical, Inc. Stent graft delivery systems and associated methods
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US9861361B2 (en) 2010-09-30 2018-01-09 Ethicon Llc Releasable tissue thickness compensator and fastener cartridge having the same
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US11925354B2 (en) 2010-09-30 2024-03-12 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US9517063B2 (en) 2012-03-28 2016-12-13 Ethicon Endo-Surgery, Llc Movable member for use with a tissue thickness compensator
US9295464B2 (en) 2010-09-30 2016-03-29 Ethicon Endo-Surgery, Inc. Surgical stapler anvil comprising a plurality of forming pockets
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US8695866B2 (en) 2010-10-01 2014-04-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a power control circuit
RU2606493C2 (en) 2011-04-29 2017-01-10 Этикон Эндо-Серджери, Инк. Staple cartridge, containing staples, located inside its compressible part
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US9228859B2 (en) * 2011-09-26 2016-01-05 Northeastern University Customizable embedded sensors
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
CN104334098B (en) 2012-03-28 2017-03-22 伊西康内外科公司 Tissue thickness compensator comprising capsules defining a low pressure environment
MX353040B (en) 2012-03-28 2017-12-18 Ethicon Endo Surgery Inc Retainer assembly including a tissue thickness compensator.
CN104321024B (en) 2012-03-28 2017-05-24 伊西康内外科公司 Tissue thickness compensator comprising a plurality of layers
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
BR112014032776B1 (en) 2012-06-28 2021-09-08 Ethicon Endo-Surgery, Inc SURGICAL INSTRUMENT SYSTEM AND SURGICAL KIT FOR USE WITH A SURGICAL INSTRUMENT SYSTEM
US20140001231A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Firing system lockout arrangements for surgical instruments
US9408606B2 (en) 2012-06-28 2016-08-09 Ethicon Endo-Surgery, Llc Robotically powered surgical device with manually-actuatable reversing system
RU2636861C2 (en) 2012-06-28 2017-11-28 Этикон Эндо-Серджери, Инк. Blocking of empty cassette with clips
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US20140005718A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Multi-functional powered surgical device with external dissection features
EP2882381B1 (en) 2012-08-10 2018-12-26 Lombard Medical Limited Stent delivery system
EP2719355A3 (en) * 2012-10-11 2014-05-21 Cook Medical Technologies LLC Clutched-gear handle for fiducial deployment
MX364729B (en) 2013-03-01 2019-05-06 Ethicon Endo Surgery Inc Surgical instrument with a soft stop.
RU2672520C2 (en) 2013-03-01 2018-11-15 Этикон Эндо-Серджери, Инк. Hingedly turnable surgical instruments with conducting ways for signal transfer
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9883860B2 (en) 2013-03-14 2018-02-06 Ethicon Llc Interchangeable shaft assemblies for use with a surgical instrument
US9737426B2 (en) 2013-03-15 2017-08-22 Altura Medical, Inc. Endograft device delivery systems and associated methods
US9867612B2 (en) 2013-04-16 2018-01-16 Ethicon Llc Powered surgical stapler
BR112015026109B1 (en) 2013-04-16 2022-02-22 Ethicon Endo-Surgery, Inc surgical instrument
RU2678363C2 (en) 2013-08-23 2019-01-28 ЭТИКОН ЭНДО-СЕРДЖЕРИ, ЭлЭлСи Firing member retraction devices for powered surgical instruments
US9510828B2 (en) 2013-08-23 2016-12-06 Ethicon Endo-Surgery, Llc Conductor arrangements for electrically powered surgical instruments with rotatable end effectors
WO2015034870A2 (en) * 2013-09-03 2015-03-12 Arocha Max Double-chamber mixing syringe and method of use
DE102013015845A1 (en) * 2013-09-24 2015-03-26 Urotech Gmbh Placement device for a medical catheter
GB2520562B (en) 2013-11-26 2017-07-26 Cook Medical Technologies Llc System and method for delivering material into a patient
ES2791290T3 (en) * 2014-01-27 2020-11-03 Allergan Holdings France S A S Substance delivery device
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
WO2015122921A1 (en) 2014-02-14 2015-08-20 Green Richard Dennis Gas removal systems and methods
US10874805B2 (en) 2014-02-14 2020-12-29 Ailnh, Llc Gas removal apparatus and related methods
JP6462004B2 (en) 2014-02-24 2019-01-30 エシコン エルエルシー Fastening system with launcher lockout
US20150272582A1 (en) 2014-03-26 2015-10-01 Ethicon Endo-Surgery, Inc. Power management control systems for surgical instruments
BR112016021943B1 (en) 2014-03-26 2022-06-14 Ethicon Endo-Surgery, Llc SURGICAL INSTRUMENT FOR USE BY AN OPERATOR IN A SURGICAL PROCEDURE
US10013049B2 (en) 2014-03-26 2018-07-03 Ethicon Llc Power management through sleep options of segmented circuit and wake up control
US9820738B2 (en) 2014-03-26 2017-11-21 Ethicon Llc Surgical instrument comprising interactive systems
US20150297223A1 (en) 2014-04-16 2015-10-22 Ethicon Endo-Surgery, Inc. Fastener cartridges including extensions having different configurations
US10426476B2 (en) 2014-09-26 2019-10-01 Ethicon Llc Circular fastener cartridges for applying radially expandable fastener lines
BR112016023807B1 (en) 2014-04-16 2022-07-12 Ethicon Endo-Surgery, Llc CARTRIDGE SET OF FASTENERS FOR USE WITH A SURGICAL INSTRUMENT
CN106456176B (en) 2014-04-16 2019-06-28 伊西康内外科有限责任公司 Fastener cartridge including the extension with various configuration
US10561422B2 (en) 2014-04-16 2020-02-18 Ethicon Llc Fastener cartridge comprising deployable tissue engaging members
BR112016023825B1 (en) 2014-04-16 2022-08-02 Ethicon Endo-Surgery, Llc STAPLE CARTRIDGE FOR USE WITH A SURGICAL STAPLER AND STAPLE CARTRIDGE FOR USE WITH A SURGICAL INSTRUMENT
US9788836B2 (en) 2014-09-05 2017-10-17 Ethicon Llc Multiple motor control for powered medical device
BR112017004361B1 (en) 2014-09-05 2023-04-11 Ethicon Llc ELECTRONIC SYSTEM FOR A SURGICAL INSTRUMENT
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US10105142B2 (en) 2014-09-18 2018-10-23 Ethicon Llc Surgical stapler with plurality of cutting elements
BR112017005981B1 (en) 2014-09-26 2022-09-06 Ethicon, Llc ANCHOR MATERIAL FOR USE WITH A SURGICAL STAPLE CARTRIDGE AND SURGICAL STAPLE CARTRIDGE FOR USE WITH A SURGICAL INSTRUMENT
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
BR112017012996B1 (en) 2014-12-18 2022-11-08 Ethicon Llc SURGICAL INSTRUMENT WITH AN ANvil WHICH IS SELECTIVELY MOVABLE ABOUT AN IMMOVABLE GEOMETRIC AXIS DIFFERENT FROM A STAPLE CARTRIDGE
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US10004501B2 (en) 2014-12-18 2018-06-26 Ethicon Llc Surgical instruments with improved closure arrangements
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US10182816B2 (en) 2015-02-27 2019-01-22 Ethicon Llc Charging system that enables emergency resolutions for charging a battery
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US10441279B2 (en) 2015-03-06 2019-10-15 Ethicon Llc Multiple level thresholds to modify operation of powered surgical instruments
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10548504B2 (en) 2015-03-06 2020-02-04 Ethicon Llc Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
JP2020121162A (en) 2015-03-06 2020-08-13 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ Time dependent evaluation of sensor data to determine stability element, creep element and viscoelastic element of measurement
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
USD811585S1 (en) 2015-08-13 2018-02-27 Richard Green Air removal device
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10603039B2 (en) 2015-09-30 2020-03-31 Ethicon Llc Progressively releasable implantable adjunct for use with a surgical stapling instrument
US20170086829A1 (en) 2015-09-30 2017-03-30 Ethicon Endo-Surgery, Llc Compressible adjunct with intermediate supporting structures
USD774181S1 (en) * 2015-11-10 2016-12-13 Richard Green Air removal device
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
CN108882932B (en) 2016-02-09 2021-07-23 伊西康有限责任公司 Surgical instrument with asymmetric articulation configuration
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US10245029B2 (en) 2016-02-09 2019-04-02 Ethicon Llc Surgical instrument with articulating and axially translatable end effector
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
USD826397S1 (en) * 2016-03-01 2018-08-21 Ailnh, Llc Air removal device
USD818117S1 (en) * 2016-03-01 2018-05-15 Ailnh, Llc Air removal device
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10376263B2 (en) 2016-04-01 2019-08-13 Ethicon Llc Anvil modification members for surgical staplers
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US20170296173A1 (en) 2016-04-18 2017-10-19 Ethicon Endo-Surgery, Llc Method for operating a surgical instrument
US10368867B2 (en) 2016-04-18 2019-08-06 Ethicon Llc Surgical instrument comprising a lockout
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US20180168633A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Surgical stapling instruments and staple-forming anvils
US10736629B2 (en) 2016-12-21 2020-08-11 Ethicon Llc Surgical tool assemblies with clutching arrangements for shifting between closure systems with closure stroke reduction features and articulation and firing systems
US10758230B2 (en) 2016-12-21 2020-09-01 Ethicon Llc Surgical instrument with primary and safety processors
US10835245B2 (en) 2016-12-21 2020-11-17 Ethicon Llc Method for attaching a shaft assembly to a surgical instrument and, alternatively, to a surgical robot
US10537325B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Staple forming pocket arrangement to accommodate different types of staples
US20180168615A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
CN110099619B (en) 2016-12-21 2022-07-15 爱惜康有限责任公司 Lockout device for surgical end effector and replaceable tool assembly
US10898186B2 (en) 2016-12-21 2021-01-26 Ethicon Llc Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls
US10695055B2 (en) 2016-12-21 2020-06-30 Ethicon Llc Firing assembly comprising a lockout
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US10835247B2 (en) 2016-12-21 2020-11-17 Ethicon Llc Lockout arrangements for surgical end effectors
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11179155B2 (en) 2016-12-21 2021-11-23 Cilag Gmbh International Anvil arrangements for surgical staplers
BR112019011947A2 (en) 2016-12-21 2019-10-29 Ethicon Llc surgical stapling systems
US20180168577A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Axially movable closure system arrangements for applying closure motions to jaws of surgical instruments
US10888322B2 (en) 2016-12-21 2021-01-12 Ethicon Llc Surgical instrument comprising a cutting member
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
JP7010956B2 (en) 2016-12-21 2022-01-26 エシコン エルエルシー How to staple tissue
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US11389161B2 (en) 2017-06-28 2022-07-19 Cilag Gmbh International Surgical instrument comprising selectively actuatable rotatable couplers
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US10758232B2 (en) 2017-06-28 2020-09-01 Ethicon Llc Surgical instrument with positive jaw opening features
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
EP4070740A1 (en) 2017-06-28 2022-10-12 Cilag GmbH International Surgical instrument comprising selectively actuatable rotatable couplers
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11944300B2 (en) 2017-08-03 2024-04-02 Cilag Gmbh International Method for operating a surgical system bailout
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
EP3988074A1 (en) 2017-12-03 2022-04-27 West Pharma. Services IL, Ltd Liquid transfer device with telescopic vial adapter for use with infusion liquid container and discrete injection vial
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US20190192147A1 (en) 2017-12-21 2019-06-27 Ethicon Llc Surgical instrument comprising an articulatable distal head
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
USD903864S1 (en) * 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (en) 2019-01-17 2019-12-16
WO2020157719A1 (en) 2019-01-31 2020-08-06 West Pharma. Services Il, Ltd Liquid transfer device
JP7430653B2 (en) 2019-02-06 2024-02-13 テルモ株式会社 Implant placement equipment and implants
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
IL307176A (en) 2019-04-30 2023-11-01 West Pharma Services Il Ltd Liquid transfer device with dual lumen iv spike
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11241235B2 (en) 2019-06-28 2022-02-08 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
US11737748B2 (en) 2020-07-28 2023-08-29 Cilag Gmbh International Surgical instruments with double spherical articulation joints with pivotable links
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11944296B2 (en) 2020-12-02 2024-04-02 Cilag Gmbh International Powered surgical instruments with external connectors
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11950777B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Staple cartridge comprising an information access control system
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11950779B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11944336B2 (en) 2021-03-24 2024-04-02 Cilag Gmbh International Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11826047B2 (en) 2021-05-28 2023-11-28 Cilag Gmbh International Stapling instrument comprising jaw mounts
US11957337B2 (en) 2021-10-18 2024-04-16 Cilag Gmbh International Surgical stapling assembly with offset ramped drive surfaces
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11937816B2 (en) 2021-10-28 2024-03-26 Cilag Gmbh International Electrical lead arrangements for surgical instruments

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197846A (en) * 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
EP0563983A1 (en) * 1992-04-03 1993-10-06 United States Surgical Corporation Endoscopic material delivery device
US5342394A (en) * 1990-05-16 1994-08-30 Olympus Optical Co., Ltd. Apparatus for blocking a vein branch and method of blocking a vein branch
WO1996004954A1 (en) * 1994-08-17 1996-02-22 Boston Scientific Corporation Implant, and method and device for inserting the implant
US5632746A (en) * 1989-08-16 1997-05-27 Medtronic, Inc. Device or apparatus for manipulating matter
WO1997019643A2 (en) * 1995-12-01 1997-06-05 Endomatrix, Inc. Device, system and method for implantation of filaments and particles in the body

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5243997A (en) * 1992-09-14 1993-09-14 Interventional Technologies, Inc. Vibrating device for a guide wire
US5524635A (en) * 1992-09-14 1996-06-11 Interventional Technologies Inc. Apparatus for advancing a guide wire
US5443078A (en) * 1992-09-14 1995-08-22 Interventional Technologies, Inc. Method for advancing a guide wire
US5713948A (en) * 1995-07-19 1998-02-03 Uflacker; Renan Adjustable and retrievable graft and graft delivery system for stent-graft system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197846A (en) * 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
US5632746A (en) * 1989-08-16 1997-05-27 Medtronic, Inc. Device or apparatus for manipulating matter
US5342394A (en) * 1990-05-16 1994-08-30 Olympus Optical Co., Ltd. Apparatus for blocking a vein branch and method of blocking a vein branch
EP0563983A1 (en) * 1992-04-03 1993-10-06 United States Surgical Corporation Endoscopic material delivery device
WO1996004954A1 (en) * 1994-08-17 1996-02-22 Boston Scientific Corporation Implant, and method and device for inserting the implant
WO1997019643A2 (en) * 1995-12-01 1997-06-05 Endomatrix, Inc. Device, system and method for implantation of filaments and particles in the body

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220294545A1 (en) * 2021-03-09 2022-09-15 Apple Inc. Multi-phase-level signaling to improve data bandwidth over lossy channels
US11784731B2 (en) * 2021-03-09 2023-10-10 Apple Inc. Multi-phase-level signaling to improve data bandwidth over lossy channels

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AU734010B2 (en) 2001-05-31
EP1018949A1 (en) 2000-07-19
CA2304663A1 (en) 1999-04-15

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