WO1999021507A2 - Synthetic fibres for medical use and method of making the same - Google Patents
Synthetic fibres for medical use and method of making the same Download PDFInfo
- Publication number
- WO1999021507A2 WO1999021507A2 PCT/US1998/022810 US9822810W WO9921507A2 WO 1999021507 A2 WO1999021507 A2 WO 1999021507A2 US 9822810 W US9822810 W US 9822810W WO 9921507 A2 WO9921507 A2 WO 9921507A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fiber
- component
- cavities
- polymer
- longitudinally
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/24—Formation of filaments, threads, or the like with a hollow structure; Spinnerette packs therefor
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
- D01D5/36—Matrix structure; Spinnerette packs therefor
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/12—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one polyamide as constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
Definitions
- the present invention relates to synthetic fibers for medical use and methods for making such synthetic fibers, and, more particularly, to synthetic fibers having cavities adapted to hold relatively large quantities of a medicament, for use in forming sutures, textile prostheses and medicated epidermal pads.
- U.S. Patent No. 5,010,167 to Ron et al. discloses biocompatible, biodegradable polymers useful for making controlled release devices for drug delivery, such as bioabsorbable sutures, wherein the drug is incorporated directly into the polymer.
- U.S. Patent No. 4,024,871 to Stevenson incorporated herein by reference in its entirety, discloses multifilament suture stands that are impregnated with an antimicrobial agent and top coated with a segmented polymer, such that the sutures retain antimicrobial properties over an extended period of time. The antimicrobial agent is distributed substantially throughout the suture in the interstices between strands and between individual filaments.
- U.S. Patent No. 5,378,540 to Olson discloses coating an absorbable braided suture with a solution that controls the release of chemical or pharmaceutical agents as the suture is absorbed into living tissue.
- U.S. Patent No. 4,841 ,968 to Dunn et al. discloses biodegradable sutures having a core and sheath configuration, wherein the core comprises a blend of a polymer and an agent to be released into living tissue, and the sheath comprises only the polymer.
- a synthetic fiber is formed with a plurality of longitudinally-extending cavities which hold a medicament intended to be absorbed into living tissue brought into contact with the fiber.
- the fiber can be formed by dissolving a soluble polymer component of an extruded plural-component fiber, leaving cavities that extend inward from the outer surface of the fiber in the locations of the dissolved polymer. After the fiber has been exposed to a solvent, the cavities left by the dissolved component are filled with a medicament. Specifically, the cavities are filled with a medicament that is mixed with a viscous carrier which solidifies within the cavities.
- the fibers can be used to make sutures, textile prostheses for insertion into the body, and epidermal pads and bandages.
- Fibers having internal cavities can be formed by extruding a single-component fiber from a spinneret orifice having a number of T-shaped slots extending from a central hub.
- a medicament is introduced into the internal cavities by soaking the fiber in a liquid containing the medicament.
- the internal-cavity fiber is therefore formed of polymer having some capability for liquid transport, e.g., nylon.
- a fiber with external cavities can be formed from a similar process by modifying one or more of the extrusion parameters.
- the fiber of the present invention includes cavities or reservoirs specifically designed to hold a medicament, these fiber advantageously hold significantly more medicine that prior art fibers relying on absorption of a medicament by a fiber or formation of a polymer into which a medicament is intermixed.
- Fig. 1 is a transverse cross-sectional view of an island-in-the-sea bicomponent fiber having longitudinal "island” components along the fiber surface, wherein the "island” components are dissolvable in a solvent.
- Fig. 2 is a transverse cross-sectional view of the synthetic fiber shown in Fig. 1 , wherein the "island" components have been dissolved, leaving longitudinal cavities along the fiber surface, wherein the cavities have substantially round cross- sectional shapes.
- Fig. 3 is a transverse cross-sectional view of the synthetic fiber of Fig. 2, wherein the cavities are filled with a medicament in accordance with a first embodiment of the present invention.
- Fig. 4 is a cross-sectional view of a spin pack suitable for extruding the synthetic fiber shown in Fig. 1.
- Fig. 5 is a transverse cross-sectional view of a synthetic fiber of the present invention, having longitudinal cavities along the fiber surface, wherein the cavities have cross-sectional shapes elongated in the radial direction.
- Fig. 6 is transverse cross-sectional view of a synthetic fiber of the present invention having arcuate, internal longitudinal cavities.
- Fig. 7 is a spinneret orifice for forming a single component synthetic fiber having internal or surface longitudinal cavities for holding a medicament.
- synthetic textile fibers, monofilaments and multifilament yarns are formed from fibers having open voids or reservoirs that can be filled with a medicament or other additives with beneficial medical uses, for subsequent absorption into the body.
- the terms “medicine”, “medicament” and “medication” refer to any substance, agent, compound or composition of matter intended to interact with tissue or bodily fluids to treat or prevent disease or damage, cause a pharmacologic or physiologic response, or to provide some other beneficial or therapeutic effect, including, but not limited to: all types of therapeutic agents, such as antiseptics, including antibiotics, antimicrobial, antibacterial and antiviral agents, analgesics, anesthetics, anorexics, anthemidines, antiarthritics, antiasthmatic agents, anticonvulsants, antidepressants, antidiabetic agents, antidiarheals, antihistamines, antiinflammatory agents, antimigraine agents, antimotion sickness agents, antinauseants, antineoplastics, antiparkinsonism drugs, antipruitics, antipsychotics, antipyretics, antispasmodics including gastrointestinal and urinary, anticholinergics, sympathomimetics, xanthine derivative
- an extruded synthetic fiber according to an exemplary embodiment of the present invention is shown in transverse cross section at three different stages of the manufacturing process.
- an extruded bicomponent fiber 10 is a so-called “island-in-the-sea” fiber with a substantially circular cross sectional shape.
- fiber 10 comprises a durable "sea" polymer 12, which forms the bulk of fiber 10, and four polymer "islands" 14 having substantially circular cross sections.
- the polymer islands 14 are embedded in the sea polymer 12 and lie along the outer surface of fiber 10, spaced apart by approximately 90°, such that the islands 14 are not totally encapsulated by the sea polymer 12, and a portion of the outer surface of fiber 10 is formed by the polymer islands 14.
- the sea polymer 12 of fiber 10 may be made from any organic high polymer such as nylon, polyethylene terepthalate, or polypropylene, or from absorbable polymers such as polymerized vinyl alcohol or more modern absorbable co-polymers. As used herein, the term "polymer” includes all such materials (both polymers and co-polymers).
- the polymer islands 14 are composed of a polymer, such as polyvinyl alcohol, which can later be dissolved in water, alcohol or another suitable solvent. Importantly, sea polymer 12 is does not dissolve in the solvent in which polymer islands 14 dissolve.
- bicomponent island-in-the-sea fiber 10 shown in Fig. 1 can be by melt, dry or wet spinning.
- bicomponent fiber 10 can be made by bicomponent spinning, using equipment of the general type disclosed in U.S. Patent Nos. 4,370,114 or 4,381 ,274, the disclosures of which are incorporated herein by reference in their entirety.
- Fig. 4 is a cross-sectional view of a spin pack 20 that is a simplified version of the spin pack shown in Fig. 1a of U.S. Patent No. 4,370,114 and that is suitable for generating bicomponent island-in-the-sea fiber 10.
- Spin pack 20 includes upstream openings 22 and 24 through which the island polymer and sea polymer respectively enter spin pack 20.
- the island polymer travels through capillary tubes 26 which inject the island polymer into the flow of the sea polymer at the entrance to spinneret 28 in four discrete locations along the edge of the spinneret entrance.
- the polymers flow through spinneret 28 to an orifice 30, where they are extruded as island-in-the-sea fiber 10.
- bicomponent fiber 10 is formed, it is treated with a suitable solvent, such as water, to dissolve the polymer islands 14. As shown in Fig. 2, polymer islands 14 are removed by exposure to the solvent, leaving a single component (i.e., the sea polymer 12) fiber 10' having longitudinally-extending voids or cavities 16 along the surface of fiber 10' in the locations formerly occupied by the dissolved polymer islands 14. If the fibers are to be made into a fabric, it is preferable to form the fabric prior to exposure to the solvent (with the polymer islands 14 in place), and subsequently to wash the fabric in water, alcohol or some other suitable solvent to remove the polymer islands 14, leaving cavities 16 on the surface of the fibers. It will be understood that the cavities formed in the fibers of the present invention are not interstitial spaces lying between separate, adjacent polymer filaments or strands; rather, the cavities are voids formed in an otherwise solid polymer fiber.
- a suitable solvent such as water
- cavities 16 left along the outer surface of fiber 10' by the dissolved islands 14 serve as reservoirs that are filled with a medicament 18 to form a fiber 10".
- Medicament 18 can be added to the fiber by dipping the fiber (or a fabric, felt, or other textile product made from the fibers) in a bath containing the medicament in a suitable carrier.
- the carrier is preferable a somewhat viscous carrier so that the medicament 18 and carrier can solidify by drying and/or cooling at room temperature before the medicament/carrier can drain out of the fiber cavities. Treating of the fibers 10' (Fig. 2) with a medicament/carrier to form fiber 10"
- sutures or fabrics made from the extruded and solvent-treated fiber 10', or fiber 10' itself are general purpose fibers, sutures and fabrics that can be later treated with any desired medicament/carrier mixture for a particular application.
- the medicament is of the type absorbed into the body over a period of time after the medical element formed from the fiber (e.g., a suture, textile prosthesis, or epidermal pad) has been deployed in or on the body.
- the medical element formed from the fiber e.g., a suture, textile prosthesis, or epidermal pad
- a medicament is added to the island polymer prior to fiber spinning (by melt, dry or wet spinning) to produce the desired end use fiber in one step. That is, the island polymer is extruded with the desired medicament incorporated therein, such that the extruded fiber is used directly in the final medical product without requiring the island components to be dissolved or the fiber to be dipped in a medicament/carrier mixture. Fibers produced in this manner are of a single purpose type, having a particular medicament that is predetermined at the time of extrusion.
- a fiber 50 having a substantially circular transverse cross-sectional profile, comprises an extruded "sea" polymer 52, with four longitudinally-extending cavities 54 created by dissolving four polymer islands that are partially embedded in the sea polymer and form part of the outer surface of the extruded fiber.
- the cavities 54 are spaced apart by approximately 90°, and each of cavities 54 has a substantially pointed elliptical transverse cross-section shape, with the major elliptical axis lying along a radial line.
- the cavities 54 extend to the outer surface of fiber 50, where the elliptical shape of the cavities is truncated. As seen in Fig. 5, the shape of cavities 54 results in sea polymer 52 having a substantially cruciform shape with the circular profile of fiber 50.
- fiber 50 is similar to fiber 10' (Fig. 2) except that the cavities are elongated in the radial direction.
- the fibers of the present invention can include external (i.e., on the fiber surface) medicament-holding cavities having any of variety of different transverse cross-sectional shapes, and the present invention is not limited to the particular cross-sectional shapes shown in the figures. Further, number of cavities can be any suitable number (one or more) of external cavities.
- an extruded fiber includes one or more internal longitudinal cavities (i.e., cavities not extending to the outer surface of the fiber), which cavities lie in relatively close proximity to the fiber surface.
- a fiber 60 having internal cavities for storing a medicament is shown.
- fiber 60 has a substantially circular transverse cross-sectional profile, and comprises an extruded polymer 62 with five longitudinally-extending internal cavities 64.
- Each of cavities 64 has an arcuate transverse cross-section shape, and cavities 64 together form a ring of arcuate cavities lying along a circle concentric with fiber 60 (i.e., the circle lies at a fixed radial distance from the center of fiber 60).
- Fiber 60 and other fibers having internal cavities, can be made without the need for bicomponent spinning by employing a spinneret orifice of a suitable shape.
- Fig. 7 illustrates a spinneret face 70 having formed therein an orifice 72 suitable for extruding fiber 60 (Fig. 6).
- Orifice 72 includes five T-shaped slots extending radially outward from a circular, central hub opening. The circumferential portions of the T- shaped slots are arcuate and form an outer circular ring of openings, with gaps 74 between adjacent slots 72.
- a medicament can be added to fiber 60 by soaking fiber 60 in a liquid containing the medicament and, optionally, pressurizing the liquid to speed liquid transport into the fiber cavities 64. Consequently, fiber 60 is preferably made from a polymer with some capability for liquid transport, such as nylon.
- the internal-cavity fiber 60 has several advantages over a simple hollow fiber with a single, central hole. Specifically, a hollow fiber with a small, single, central hole has a limited capacity to hold medicine, and transport of the medicine to the surrounding tissue is slow due to the thick fiber wall. Conversely, a hollow fiber having a large internal hole holds more medicine; however, such a fiber tends to collapse and cause processing problems in knitting, weaving or, in the case of sutures, the tying of knots.
- the internal-cavity fiber of the present invention because the fiber cavities are formed closer to the exterior surface of the fiber, the medicament can be transported to the surrounding tissue more rapidly than with fiber having a small, single, central cavity. Further, the medicament is distributed through several cavities, so that a large quantity of medicament can be held in the fiber without the aforementioned problems associated with fiber having a large, single, central hole.
- the internal-cavity fiber of the present invention is not limited to the particular configuration shown in Fig. 6.
- the cavities need not be arcuate and can have any cross-sectional shape.
- the cavities need not be the same size and need not lie at the same radial distance from the fiber center. Further any suitable number of internal cavities can be formed.
- Fibers of the type described above have a variety of different medical applications and also some non-medical applications, including, but not limited to: fabrics for wound dressings and adhesive bandage pads, where the fibers contain an antiseptic or an agent to promote healing; textile prostheses where the base polymer (or copolymer) is an absorbable type and can be left to gradually disintegrate in the body, or where the base polymer is tissue-compatible and remains in the body; sutures of the absorbable or non-absorbable type made from monofilament or twisted or braided multifilaments; and patches for application to the skin where the fiber cavities contain a component such as nicotine for slow absorption into the skin.
- fabrics for wound dressings and adhesive bandage pads where the fibers contain an antiseptic or an agent to promote healing
- textile prostheses where the base polymer (or copolymer) is an absorbable type and can be left to gradually disintegrate in the body, or where the base polymer is tissue-compatible and remains in the body
- the fibers can be used in a number of non-medical applications, including, but not limited to: fibrous inking pads for rubber stamping and for the printing industry, wherein fibers such as those shown in Figs. 2 and 5 have the longitudinal cavities filled with viscous ink; fabrics, felts or fiber masses formed from a fiber having a maximum number of empty small surface grooves and used as absorbent pads in medical or non-medical applications.
- Such pads can be used, for example, to absorb oil from tanker oil spills, and then wrung out and reused. Fibers such as nylon will withstand many more cycles of absorption and wringing than conventional cotton fibers used in this manner.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/530,183 US6551353B1 (en) | 1997-10-28 | 1998-10-28 | Synthetic fibers for medical use and method of making the same |
AU12824/99A AU1282499A (en) | 1997-10-28 | 1998-10-28 | Synthetic fibres for medical use and method of making the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6334597P | 1997-10-28 | 1997-10-28 | |
US60/063,345 | 1997-10-28 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/530,183 A-371-Of-International US6551353B1 (en) | 1997-10-28 | 1998-10-28 | Synthetic fibers for medical use and method of making the same |
US10/373,057 Division US20030138480A1 (en) | 1997-10-28 | 2003-02-26 | Synthetic fibers for medical use and method of making the same |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999021507A2 true WO1999021507A2 (en) | 1999-05-06 |
WO1999021507A3 WO1999021507A3 (en) | 1999-07-22 |
Family
ID=22048573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/022810 WO1999021507A2 (en) | 1997-10-28 | 1998-10-28 | Synthetic fibres for medical use and method of making the same |
Country Status (3)
Country | Link |
---|---|
US (2) | US6551353B1 (en) |
AU (1) | AU1282499A (en) |
WO (1) | WO1999021507A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207274B1 (en) | 1999-12-21 | 2001-03-27 | International Flavors & Fragrances Inc. | Fragrance containing fiber |
WO2001047459A1 (en) * | 1999-12-23 | 2001-07-05 | Johnson & Johnson Medical Limited | Absorbent medicinal articles |
US6500444B1 (en) | 1999-12-21 | 2002-12-31 | International Flavors & Fragrances Inc. | Continuously fragrance-emitting dry or wet wipe fabric article and method for preparing same |
US8968362B2 (en) | 2010-04-08 | 2015-03-03 | Covidien Lp | Coated looped suture |
WO2018078562A1 (en) | 2016-10-26 | 2018-05-03 | Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) | Fibers with segments, their preparation and applications thereof |
EP3919673A4 (en) * | 2019-01-30 | 2023-05-03 | Toray Industries, Inc. | Water-repellent woven article, production method for same, and garment |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1289815B1 (en) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS |
US6540780B1 (en) * | 1998-11-23 | 2003-04-01 | Medtronic, Inc. | Porous synthetic vascular grafts with oriented ingrowth channels |
EP1132058A1 (en) | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
US6979347B1 (en) * | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
US6758859B1 (en) * | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
ATE330564T1 (en) * | 2001-07-20 | 2006-07-15 | Sorin Biomedica Cardio Srl | STENT |
DE10150995A1 (en) * | 2001-10-08 | 2003-04-10 | Biotronik Mess & Therapieg | Implant e.g. a stent, comprises a decomposable substance which allows contact between the cell proliferation inhibitor and the stent surroundings only after a specified time |
US6861142B1 (en) * | 2002-06-06 | 2005-03-01 | Hills, Inc. | Controlling the dissolution of dissolvable polymer components in plural component fibers |
US20030236219A1 (en) * | 2002-06-21 | 2003-12-25 | Nightingale Stephen D. | Edible product markers and methods for making and using edible product markers |
NZ537729A (en) * | 2002-06-21 | 2006-07-28 | Stephen D Nightingale | Multi-functional product markers and methods for making and using the same |
US7135038B1 (en) * | 2002-09-30 | 2006-11-14 | Advanced Cardiovascular Systems, Inc. | Drug eluting stent |
US7776101B2 (en) * | 2003-06-18 | 2010-08-17 | Gore Enterprise Holdings, Inc. | Soft tissue defect repair device |
US6991637B2 (en) * | 2003-06-18 | 2006-01-31 | Gore Enterprise Holdings, Inc. | Soft tissue defect repair device |
US20040260034A1 (en) | 2003-06-19 | 2004-12-23 | Haile William Alston | Water-dispersible fibers and fibrous articles |
US8513147B2 (en) | 2003-06-19 | 2013-08-20 | Eastman Chemical Company | Nonwovens produced from multicomponent fibers |
US7687143B2 (en) * | 2003-06-19 | 2010-03-30 | Eastman Chemical Company | Water-dispersible and multicomponent fibers from sulfopolyesters |
US7892993B2 (en) | 2003-06-19 | 2011-02-22 | Eastman Chemical Company | Water-dispersible and multicomponent fibers from sulfopolyesters |
US20050133948A1 (en) * | 2003-12-22 | 2005-06-23 | Cook Michael C. | Apparatus and method for multicomponent fibers |
WO2006026397A2 (en) * | 2004-08-26 | 2006-03-09 | Stout Medical Group, L.P. | Sutures and methods of making the same |
AU2005295811B2 (en) * | 2004-10-18 | 2011-03-03 | Covidien Lp | Adhesive suture structure and methods of using the same |
CA2585634A1 (en) * | 2004-10-29 | 2006-05-11 | Adhesives Research, Inc. | Microscopic tagging system for security identification |
US8303604B2 (en) | 2004-11-05 | 2012-11-06 | Biomet Sports Medicine, Llc | Soft tissue repair device and method |
US9801708B2 (en) | 2004-11-05 | 2017-10-31 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7658751B2 (en) | 2006-09-29 | 2010-02-09 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US8118836B2 (en) | 2004-11-05 | 2012-02-21 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US7905904B2 (en) | 2006-02-03 | 2011-03-15 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US7749250B2 (en) | 2006-02-03 | 2010-07-06 | Biomet Sports Medicine, Llc | Soft tissue repair assembly and associated method |
US7909851B2 (en) | 2006-02-03 | 2011-03-22 | Biomet Sports Medicine, Llc | Soft tissue repair device and associated methods |
US8298262B2 (en) | 2006-02-03 | 2012-10-30 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US8088130B2 (en) | 2006-02-03 | 2012-01-03 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9017381B2 (en) | 2007-04-10 | 2015-04-28 | Biomet Sports Medicine, Llc | Adjustable knotless loops |
US8361113B2 (en) | 2006-02-03 | 2013-01-29 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US8128658B2 (en) | 2004-11-05 | 2012-03-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to bone |
US20060189993A1 (en) * | 2004-11-09 | 2006-08-24 | Arthrotek, Inc. | Soft tissue conduit device |
US8137382B2 (en) | 2004-11-05 | 2012-03-20 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US11311287B2 (en) | 2006-02-03 | 2022-04-26 | Biomet Sports Medicine, Llc | Method for tissue fixation |
US11259792B2 (en) | 2006-02-03 | 2022-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for coupling anatomical features |
US10517587B2 (en) | 2006-02-03 | 2019-12-31 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US9149267B2 (en) | 2006-02-03 | 2015-10-06 | Biomet Sports Medicine, Llc | Method and apparatus for coupling soft tissue to a bone |
US9538998B2 (en) | 2006-02-03 | 2017-01-10 | Biomet Sports Medicine, Llc | Method and apparatus for fracture fixation |
US8562645B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8936621B2 (en) | 2006-02-03 | 2015-01-20 | Biomet Sports Medicine, Llc | Method and apparatus for forming a self-locking adjustable loop |
US8968364B2 (en) | 2006-02-03 | 2015-03-03 | Biomet Sports Medicine, Llc | Method and apparatus for fixation of an ACL graft |
US8801783B2 (en) | 2006-09-29 | 2014-08-12 | Biomet Sports Medicine, Llc | Prosthetic ligament system for knee joint |
US8562647B2 (en) | 2006-09-29 | 2013-10-22 | Biomet Sports Medicine, Llc | Method and apparatus for securing soft tissue to bone |
US9078644B2 (en) | 2006-09-29 | 2015-07-14 | Biomet Sports Medicine, Llc | Fracture fixation device |
US8597327B2 (en) | 2006-02-03 | 2013-12-03 | Biomet Manufacturing, Llc | Method and apparatus for sternal closure |
US8652171B2 (en) | 2006-02-03 | 2014-02-18 | Biomet Sports Medicine, Llc | Method and apparatus for soft tissue fixation |
US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US7737060B2 (en) * | 2006-03-31 | 2010-06-15 | Boston Scientific Scimed, Inc. | Medical devices containing multi-component fibers |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
CA2655793A1 (en) | 2006-06-29 | 2008-01-03 | Boston Scientific Limited | Medical devices with selective coating |
EP2063808A4 (en) * | 2006-09-14 | 2012-06-13 | Spineology Inc | Absorbent fabric implant |
US9918826B2 (en) | 2006-09-29 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US11259794B2 (en) | 2006-09-29 | 2022-03-01 | Biomet Sports Medicine, Llc | Method for implanting soft tissue |
US8672969B2 (en) | 2006-09-29 | 2014-03-18 | Biomet Sports Medicine, Llc | Fracture fixation device |
US20090169628A1 (en) * | 2006-10-17 | 2009-07-02 | Armark Authentication Technologies, Llc | Article and method for focused delivery of therapeutic and/or diagnostic materials |
US8431149B2 (en) * | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US20080221618A1 (en) * | 2007-03-09 | 2008-09-11 | Gaoyuan Chen | Co-extruded tissue grasping monofilament |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
JP2010535541A (en) * | 2007-08-03 | 2010-11-25 | ボストン サイエンティフィック リミテッド | Coating for medical devices with large surface area |
US20090118812A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090118821A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
US8128677B2 (en) | 2007-12-12 | 2012-03-06 | Intact Vascular LLC | Device and method for tacking plaque to a blood vessel wall |
US9375327B2 (en) | 2007-12-12 | 2016-06-28 | Intact Vascular, Inc. | Endovascular implant |
US9603730B2 (en) | 2007-12-12 | 2017-03-28 | Intact Vascular, Inc. | Endoluminal device and method |
US7896911B2 (en) | 2007-12-12 | 2011-03-01 | Innovasc Llc | Device and method for tacking plaque to blood vessel wall |
US10022250B2 (en) | 2007-12-12 | 2018-07-17 | Intact Vascular, Inc. | Deployment device for placement of multiple intraluminal surgical staples |
US10166127B2 (en) | 2007-12-12 | 2019-01-01 | Intact Vascular, Inc. | Endoluminal device and method |
EP2271380B1 (en) | 2008-04-22 | 2013-03-20 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
WO2009132176A2 (en) * | 2008-04-24 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
EP2303350A2 (en) * | 2008-06-18 | 2011-04-06 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
WO2010037021A2 (en) * | 2008-09-29 | 2010-04-01 | Armark Authentication Technologies, Llc | Spinneret and method of spinning fiber |
US20100291214A1 (en) * | 2008-12-23 | 2010-11-18 | Armark Authentication Technologies, Llc | Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure |
US8512519B2 (en) | 2009-04-24 | 2013-08-20 | Eastman Chemical Company | Sulfopolyesters for paper strength and process |
US20100291384A1 (en) * | 2009-05-15 | 2010-11-18 | Armark Authentication Technologies, Llc | Fiber having non-uniform composition and method for making same |
US8501644B2 (en) * | 2009-06-02 | 2013-08-06 | Christine W. Cole | Activated protective fabric |
US8616040B2 (en) * | 2010-09-17 | 2013-12-31 | Medtronic Vascular, Inc. | Method of forming a drug-eluting medical device |
US20120183861A1 (en) | 2010-10-21 | 2012-07-19 | Eastman Chemical Company | Sulfopolyester binders |
US10390977B2 (en) | 2011-06-03 | 2019-08-27 | Intact Vascular, Inc. | Endovascular implant |
US9096955B2 (en) | 2011-09-30 | 2015-08-04 | Ut-Battelle, Llc | Method for the preparation of carbon fiber from polyolefin fiber precursor, and carbon fibers made thereby |
US9357991B2 (en) | 2011-11-03 | 2016-06-07 | Biomet Sports Medicine, Llc | Method and apparatus for stitching tendons |
US9357992B2 (en) | 2011-11-10 | 2016-06-07 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
US9381013B2 (en) | 2011-11-10 | 2016-07-05 | Biomet Sports Medicine, Llc | Method for coupling soft tissue to a bone |
CN107028691B (en) | 2012-01-25 | 2019-08-16 | 因特脉管有限公司 | Intracavitary unit and method |
US8840757B2 (en) | 2012-01-31 | 2014-09-23 | Eastman Chemical Company | Processes to produce short cut microfibers |
US9096959B2 (en) | 2012-02-22 | 2015-08-04 | Ut-Battelle, Llc | Method for production of carbon nanofiber mat or carbon paper |
US9597426B2 (en) | 2013-01-25 | 2017-03-21 | Covidien Lp | Hydrogel filled barbed suture |
US9918827B2 (en) | 2013-03-14 | 2018-03-20 | Biomet Sports Medicine, Llc | Scaffold for spring ligament repair |
US9303357B2 (en) | 2013-04-19 | 2016-04-05 | Eastman Chemical Company | Paper and nonwoven articles comprising synthetic microfiber binders |
JP6313450B2 (en) | 2013-08-29 | 2018-04-18 | テレフレックス メディカル インコーポレイテッド | High strength multi-component suture |
US9598802B2 (en) | 2013-12-17 | 2017-03-21 | Eastman Chemical Company | Ultrafiltration process for producing a sulfopolyester concentrate |
US9605126B2 (en) | 2013-12-17 | 2017-03-28 | Eastman Chemical Company | Ultrafiltration process for the recovery of concentrated sulfopolyester dispersion |
US9433520B2 (en) | 2015-01-29 | 2016-09-06 | Intact Vascular, Inc. | Delivery device and method of delivery |
US9375336B1 (en) | 2015-01-29 | 2016-06-28 | Intact Vascular, Inc. | Delivery device and method of delivery |
US10076324B2 (en) * | 2015-08-31 | 2018-09-18 | Ethicon Llc | Adjunct material to provide controlled drug elution |
US10569071B2 (en) | 2015-08-31 | 2020-02-25 | Ethicon Llc | Medicant eluting adjuncts and methods of using medicant eluting adjuncts |
US10086116B2 (en) * | 2015-08-31 | 2018-10-02 | Ethicon Llc | Adjunct material to provide controlled drug release |
US10993824B2 (en) | 2016-01-01 | 2021-05-04 | Intact Vascular, Inc. | Delivery device and method of delivery |
US20180117819A1 (en) * | 2016-10-27 | 2018-05-03 | Clemson University Research Foundation | Inherently super-omniphobic filaments, fibers, and fabrics and system for manufacture |
US11660218B2 (en) | 2017-07-26 | 2023-05-30 | Intact Vascular, Inc. | Delivery device and method of delivery |
JP7391524B2 (en) * | 2019-03-29 | 2023-12-05 | 帝人フロンティア株式会社 | Sea-island type composite fiber bundle and surface uneven fiber bundle made from the same |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5551954A (en) * | 1991-10-04 | 1996-09-03 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US3991766A (en) | 1973-05-31 | 1976-11-16 | American Cyanamid Company | Controlled release of medicaments using polymers from glycolic acid |
US3978203A (en) | 1974-07-12 | 1976-08-31 | Dynatech Corporation | Sustained release of pharmaceuticals from polyester matrices |
US4024871A (en) | 1975-07-23 | 1977-05-24 | Ethicon, Inc. | Antimicrobial sutures |
US4307723A (en) * | 1978-04-07 | 1981-12-29 | Medical Engineering Corporation | Externally grooved ureteral stent |
US4841968A (en) | 1986-09-26 | 1989-06-27 | Southern Research Institute | Antithrombotic/thrombolytic suture and methods of making and using the same |
US5162074A (en) * | 1987-10-02 | 1992-11-10 | Basf Corporation | Method of making plural component fibers |
EP0376656B1 (en) | 1988-12-29 | 1994-04-06 | Deknatel Technology Corporation | Absorbable coating and blend |
US5010167A (en) | 1989-03-31 | 1991-04-23 | Massachusetts Institute Of Technology | Poly(amide-and imide-co-anhydride) for biological application |
JP2842905B2 (en) * | 1989-12-01 | 1999-01-06 | 帝人株式会社 | Multileaf cross section elastic filament |
CA2071960C (en) * | 1990-02-20 | 1994-08-23 | Hugh Ansley Thompson | Open capillary channel structures, improved process for making capillary channel structures, and extrusion die for use therein |
US6004346A (en) * | 1990-02-28 | 1999-12-21 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5411550A (en) * | 1991-09-16 | 1995-05-02 | Atrium Medical Corporation | Implantable prosthetic device for the delivery of a bioactive material |
US5370681A (en) * | 1991-09-16 | 1994-12-06 | Atrium Medical Corporation | Polyumenal implantable organ |
US5716410A (en) * | 1993-04-30 | 1998-02-10 | Scimed Life Systems, Inc. | Temporary stent and method of use |
US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
ZA9710342B (en) * | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
US6240616B1 (en) * | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US6117802A (en) * | 1997-10-29 | 2000-09-12 | Alliedsignal Inc. | Electrically conductive shaped fibers |
US6206915B1 (en) * | 1998-09-29 | 2001-03-27 | Medtronic Ave, Inc. | Drug storing and metering stent |
US6465095B1 (en) * | 2000-09-25 | 2002-10-15 | Fiber Innovation Technology, Inc. | Splittable multicomponent fibers with partially overlapping segments and methods of making and using the same |
-
1998
- 1998-10-28 AU AU12824/99A patent/AU1282499A/en not_active Abandoned
- 1998-10-28 US US09/530,183 patent/US6551353B1/en not_active Expired - Lifetime
- 1998-10-28 WO PCT/US1998/022810 patent/WO1999021507A2/en active Application Filing
-
2003
- 2003-02-26 US US10/373,057 patent/US20030138480A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5551954A (en) * | 1991-10-04 | 1996-09-03 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207274B1 (en) | 1999-12-21 | 2001-03-27 | International Flavors & Fragrances Inc. | Fragrance containing fiber |
US6500444B1 (en) | 1999-12-21 | 2002-12-31 | International Flavors & Fragrances Inc. | Continuously fragrance-emitting dry or wet wipe fabric article and method for preparing same |
US6517759B1 (en) | 1999-12-21 | 2003-02-11 | International Flavors & Fragrances Inc. | Method of making fragrance containing fiber |
WO2001047459A1 (en) * | 1999-12-23 | 2001-07-05 | Johnson & Johnson Medical Limited | Absorbent medicinal articles |
US8968362B2 (en) | 2010-04-08 | 2015-03-03 | Covidien Lp | Coated looped suture |
US8979894B2 (en) | 2010-04-08 | 2015-03-17 | Covidien Lp | Coated looped suture |
US9687228B2 (en) | 2010-04-08 | 2017-06-27 | Covidien Lp | Coated looped suture |
WO2018078562A1 (en) | 2016-10-26 | 2018-05-03 | Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) | Fibers with segments, their preparation and applications thereof |
EP3919673A4 (en) * | 2019-01-30 | 2023-05-03 | Toray Industries, Inc. | Water-repellent woven article, production method for same, and garment |
Also Published As
Publication number | Publication date |
---|---|
US6551353B1 (en) | 2003-04-22 |
WO1999021507A3 (en) | 1999-07-22 |
US20030138480A1 (en) | 2003-07-24 |
AU1282499A (en) | 1999-05-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6551353B1 (en) | Synthetic fibers for medical use and method of making the same | |
US10920346B2 (en) | Mechanically strong absorbent non-woven fibrous mats | |
US5919473A (en) | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant | |
FI88259C (en) | SURGICAL REPARATIONSANORDNING | |
US9655609B2 (en) | Soft suture anchor | |
US7765647B2 (en) | Non-woven fiber assemblies | |
US3108357A (en) | Compound absorbable prosthetic implants, fabrics and yarns therefor | |
US9101508B2 (en) | Electro spun nanofibrous wound dressing and a method of synthesizing the same | |
KR101457341B1 (en) | Multi-component fibers produced using a rotational spinning method | |
HUT58532A (en) | Alginate febric of improved absorption and method for producing same | |
JP2003510475A (en) | Absorbent fabric | |
JP2010527414A (en) | Electronic rotating device, fiber structure manufacturing method, and electronic spun fiber structure | |
EP3704291B1 (en) | Process and system for making poly(glycerol sebacate)/alginate continuous fibers, and yarns comprising a continuous poly(glycerol sebacate) fiber | |
US20130150764A1 (en) | Non-Adherent Wound Dressings and Related Methods Therefor | |
EP2567714A1 (en) | Flocked surgical suture and methods for the production thereof | |
CN101481828A (en) | Fiber for wound dressing | |
CN1282258A (en) | Orthopedic casting articles containing backings having water soluble binders | |
CA2892249C (en) | Mechanically strong absorbent non-woven fibrous mats | |
US20200276379A1 (en) | Tissue cuff | |
WO2001047459A1 (en) | Absorbent medicinal articles | |
JPH0978453A (en) | Charging of treating liquid into hollow fiber and charging of polymer | |
CZ300142B6 (en) | Process for preparing fibrous biologically degradable materials serving as controlled release-medicament carriers | |
CZ20293U1 (en) | Nanofiber net and nanofibers with doped liposomes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 09530183 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: CA |