WO1999040106A3 - Use of angiotensin analogues for promoting erythropoiesis - Google Patents

Use of angiotensin analogues for promoting erythropoiesis Download PDF

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Publication number
WO1999040106A3
WO1999040106A3 PCT/US1999/002648 US9902648W WO9940106A3 WO 1999040106 A3 WO1999040106 A3 WO 1999040106A3 US 9902648 W US9902648 W US 9902648W WO 9940106 A3 WO9940106 A3 WO 9940106A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
angiotensin
aii
fragments
erythropoiesis
Prior art date
Application number
PCT/US1999/002648
Other languages
French (fr)
Other versions
WO1999040106A2 (en
Inventor
Kathleen E Rodgers
Gere Dizerega
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Priority to CA002319701A priority Critical patent/CA2319701C/en
Priority to JP2000530534A priority patent/JP2002509077A/en
Priority to AU25916/99A priority patent/AU2591699A/en
Priority to EP99905848A priority patent/EP1053004A2/en
Publication of WO1999040106A2 publication Critical patent/WO1999040106A2/en
Publication of WO1999040106A3 publication Critical patent/WO1999040106A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen

Abstract

The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists as a therapeutic adjunct. The method is useful for the treatment of congenital or acquired aplastic or hypoplastic anemia associated with chronic renal failure, end-stage renal disease, renal transplantation, cancer, AIDS, chemotherapy, radiotherapy, bone marrow transplantation and chronic diseases.
PCT/US1999/002648 1998-02-09 1999-02-08 Use of angiotensin analogues for promoting erythropoiesis WO1999040106A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002319701A CA2319701C (en) 1998-02-09 1999-02-08 Method of promoting erythropoiesis
JP2000530534A JP2002509077A (en) 1998-02-09 1999-02-08 Erythropoiesis promotion method
AU25916/99A AU2591699A (en) 1998-02-09 1999-02-08 Method of promoting erythropoiesis
EP99905848A EP1053004A2 (en) 1998-02-09 1999-02-08 Use of angiotensin analogues for promoting erythropoiesis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7410698P 1998-02-09 1998-02-09
US11153598P 1998-12-09 1998-12-09
US60/111,535 1998-12-09
US60/074,106 1998-12-09

Publications (2)

Publication Number Publication Date
WO1999040106A2 WO1999040106A2 (en) 1999-08-12
WO1999040106A3 true WO1999040106A3 (en) 1999-09-23

Family

ID=26755261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002648 WO1999040106A2 (en) 1998-02-09 1999-02-08 Use of angiotensin analogues for promoting erythropoiesis

Country Status (6)

Country Link
US (3) US6239109B1 (en)
EP (1) EP1053004A2 (en)
JP (1) JP2002509077A (en)
AU (1) AU2591699A (en)
CA (1) CA2319701C (en)
WO (1) WO1999040106A2 (en)

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US6916783B2 (en) * 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
CA2339330A1 (en) 1998-08-13 2000-02-24 University Of Southern California Methods to increase blood flow to ischemic tissue
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
US6821953B1 (en) 1999-12-16 2004-11-23 University Of Southern California Methods for treating and preventing damage to mucosal tissue
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US6747008B1 (en) 2000-06-19 2004-06-08 University Of Southern California Methods for treating and preventing alopecia
MXPA03011693A (en) 2001-05-31 2004-12-06 Vicore Pharma Ab Tricyclic compounds useful as angiotensin ii agonists.
US7375073B2 (en) 2002-02-27 2008-05-20 Wake Forest University Health Sciences Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
US7273896B2 (en) * 2003-04-10 2007-09-25 Angiotech Pharmaceuticals (Us), Inc. Compositions and methods of using a transient colorant
US7588745B2 (en) * 2004-04-13 2009-09-15 Si Options, Llc Silicon-containing products
CA2648035A1 (en) * 2006-03-31 2007-10-11 Centocor, Inc. Human epo mimetic hinge core mimetibodies, compositions, methods and uses for preventing or treating glucose intolerance related conditions or renal disease associated anemia
EP2187943A2 (en) * 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Gamma 1 msh alone or in combination with pentagastrin as a therapeutic agent
WO2009040051A2 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of the peptide rfmwmk alone or in combination with the peptide ymdgtmsqv as a therapeutic agent
AU2008303909A1 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of Tyr-w-Mif-1 and urocortin 2 as therapeutic agents
RU2010113981A (en) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) APPLICATION OF A HEXAPEPTIDE ANTAGONIST RECEPTOR OF THROMBOCITARY FIBRINOGEN AND ALPHA-ENDORPHINE AS A THERAPEUTIC
CN103694337B (en) 2008-02-08 2016-03-02 Ambrx公司 Modified leptin polypeptide and its purposes
US20090227507A1 (en) * 2008-03-10 2009-09-10 University Of Southern California Angiotensin (1-7) Dosage Forms and Uses Thereof
EP3225248B1 (en) 2008-07-23 2023-06-07 Ambrx, Inc. Modified bovine g-csf polypeptides and their uses
AU2009296397B2 (en) 2008-09-26 2012-11-08 Ambrx Inc. Modified animal erythropoietin polypeptides and their uses
TWI480288B (en) 2010-09-23 2015-04-11 Lilly Co Eli Formulations for bovine granulocyte colony stimulating factor and variants thereof
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
ES2649905T3 (en) * 2012-03-30 2018-01-16 Daiichi Sankyo Company, Limited Succinic (2-heteroarylamino) acid derivative
US9688724B2 (en) 2012-05-14 2017-06-27 University Of Southern California Methods for limiting development of a skin wound
US8557958B1 (en) 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
US9623084B2 (en) 2013-03-15 2017-04-18 University Of Southern California Methods for treating multiple sclerosis
WO2014145331A1 (en) 2013-03-15 2014-09-18 University Of Southern California Methods, compounds, and compositions for the treatment of angiotensin-related diseases
JP6254692B2 (en) 2013-07-03 2017-12-27 ジ アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニヴァーシティー オブ アリゾナ Methods for treating cognitive dysfunction
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
WO2016014342A2 (en) 2014-07-21 2016-01-28 Arizona Board Of Regents For The University Of Arizona Ang-(1-7) derviative oligopeptides and methods for using and producing the same
US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
CA2998862A1 (en) 2015-09-18 2017-03-23 Wake Forest University Health Sciences Angiotensin (1-7) analogs and methods relating thereto
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
EP4007592A1 (en) 2019-08-02 2022-06-08 LanthioPep B.V. Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Citations (6)

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US5015629A (en) * 1989-06-26 1991-05-14 University Of Southern California Tissue repair
WO1995008337A1 (en) * 1993-09-24 1995-03-30 The University Of Southern California Use of angiotensin iii and analogs thereof in tissue repair
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WO1998032457A2 (en) * 1997-01-28 1998-07-30 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
WO1999026644A1 (en) * 1997-11-26 1999-06-03 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
WO1999031125A1 (en) * 1997-12-12 1999-06-24 University Of Southern California Wound healing compositions

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WO1995008337A1 (en) * 1993-09-24 1995-03-30 The University Of Southern California Use of angiotensin iii and analogs thereof in tissue repair
WO1996039164A1 (en) * 1995-06-06 1996-12-12 The University Of Southern California Use of angiotensin ii type 2 receptor agonists in tissue repair
WO1998032457A2 (en) * 1997-01-28 1998-07-30 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
WO1999026644A1 (en) * 1997-11-26 1999-06-03 University Of Southern California Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
WO1999031125A1 (en) * 1997-12-12 1999-06-24 University Of Southern California Wound healing compositions

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Also Published As

Publication number Publication date
US20090062210A1 (en) 2009-03-05
EP1053004A2 (en) 2000-11-22
WO1999040106A2 (en) 1999-08-12
AU2591699A (en) 1999-08-23
CA2319701C (en) 2009-09-29
CA2319701A1 (en) 1999-08-12
US7288522B1 (en) 2007-10-30
US6239109B1 (en) 2001-05-29
JP2002509077A (en) 2002-03-26
US7745411B2 (en) 2010-06-29

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