WO1999050255A3 - Disubstituted pyrazolines and triazolines as factor xa inhibitors - Google Patents
Disubstituted pyrazolines and triazolines as factor xa inhibitors Download PDFInfo
- Publication number
- WO1999050255A3 WO1999050255A3 PCT/US1999/006310 US9906310W WO9950255A3 WO 1999050255 A3 WO1999050255 A3 WO 1999050255A3 US 9906310 W US9906310 W US 9906310W WO 9950255 A3 WO9950255 A3 WO 9950255A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- triazolines
- inhibitors
- factor
- disubstituted pyrazolines
- pyrazolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69920888T DE69920888T2 (en) | 1998-03-27 | 1999-03-23 | DISUBSTITUTED PYRAZOLINES AND TRIAZOLINES AS FACTOR XA INHIBITORS |
EP99912828A EP1064270B1 (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
AT99912828T ATE278673T1 (en) | 1998-03-27 | 1999-03-23 | DISUBSTITUTED PYRAZOLINES AND TRIAZOLINES AS FACTOR XA INHIBITORS |
JP2000541159A JP2002509924A (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor Xa inhibitors |
CA002321538A CA2321538A1 (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
AU31109/99A AU3110999A (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7972598P | 1998-03-27 | 1998-03-27 | |
US60/079,725 | 1998-03-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999050255A2 WO1999050255A2 (en) | 1999-10-07 |
WO1999050255A3 true WO1999050255A3 (en) | 1999-11-18 |
Family
ID=22152402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/006310 WO1999050255A2 (en) | 1998-03-27 | 1999-03-23 | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
Country Status (9)
Country | Link |
---|---|
US (3) | US6191159B1 (en) |
EP (1) | EP1064270B1 (en) |
JP (1) | JP2002509924A (en) |
AT (1) | ATE278673T1 (en) |
AU (1) | AU3110999A (en) |
CA (1) | CA2321538A1 (en) |
DE (1) | DE69920888T2 (en) |
ES (1) | ES2230841T3 (en) |
WO (1) | WO1999050255A2 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3110999A (en) * | 1998-03-27 | 1999-10-18 | Du Pont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
DK1140941T3 (en) | 1998-12-23 | 2005-02-14 | Bristol Myers Squibb Pharma Co | Nitrogen-containing heterobicyclic compounds as factor Xa inhibitors |
AU4307800A (en) * | 1999-04-30 | 2000-11-17 | Merab Lomia | New indication for use of antiepileptic agents and medicines |
US6329527B1 (en) | 1999-10-21 | 2001-12-11 | Bristol-Myers Squibb Pharma Company | Synthesis of 1,3,5-trisubstituted pyrazoles |
ATE373655T1 (en) * | 2000-06-23 | 2007-10-15 | Bristol Myers Squibb Pharma Co | 1-(HETEROARYL-PHENYL)-CONDENSED PYRAZOLE DERIVATIVES AS FACTOR XA INHIBITORS |
US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
RS51449B (en) * | 2001-01-26 | 2011-04-30 | Schering Corporation | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
PL204653B1 (en) | 2001-09-21 | 2010-01-29 | Bristol Myers Squibb Co | Derivative of pyrazolo [3,4-c] pyridine, the use thereof and pharmaceutical composition |
DE60216300T2 (en) * | 2001-09-21 | 2007-06-28 | Schering Corp. | TREATMENT OF XANTHOM BY AZETIDINONE DERIVATIVES AS AN INHIBITOR OF STEROL ABSORPTION |
TWI331526B (en) * | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
AU2002350217A1 (en) | 2001-12-04 | 2003-06-17 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
EP1505966A4 (en) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
CA2488202C (en) * | 2002-06-12 | 2011-03-08 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
CN1756755A (en) * | 2003-03-07 | 2006-04-05 | 先灵公司 | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
JP5137228B2 (en) * | 2003-03-07 | 2013-02-06 | メルク・シャープ・アンド・ドーム・コーポレーション | Substituted azetidinone compounds, substituted azetidinone formulations and their use for the treatment of hypercholesterolemia |
DE602004018617D1 (en) * | 2003-03-07 | 2009-02-05 | Schering Corp | SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE FOR THE TREATMENT OF HYPERCHOLESTEROLMIA |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
US7235662B2 (en) * | 2003-06-11 | 2007-06-26 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
EP1720545B1 (en) * | 2004-03-03 | 2014-10-29 | ChemoCentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
NZ571441A (en) * | 2006-03-24 | 2010-08-27 | Eisai R&D Man Co Ltd | Triazolone derivative |
CN101405275B (en) * | 2006-03-24 | 2011-11-09 | 卫材R&D管理有限公司 | Triazolone derivative |
EP2202231A4 (en) | 2007-09-21 | 2011-09-28 | Eisai R&D Man Co Ltd | 2,3-dihydroiminoisoindole derivative |
RU2557908C1 (en) * | 2014-07-04 | 2015-07-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Method of incubation of chicken eggs |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995014682A1 (en) * | 1993-11-24 | 1995-06-01 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
WO1995014683A1 (en) * | 1993-11-24 | 1995-06-01 | The Du Pont Merck Pharmaceutical Company | Novel isoxazoline and isoxazole fibrinogen receptor antagonists |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5463071A (en) * | 1991-07-27 | 1995-10-31 | Dr. Karl Thomae Gmbh | 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds |
WO1997023212A1 (en) * | 1995-12-21 | 1997-07-03 | The Du Pont Merck Pharmaceutical Company | ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS |
WO1997030971A1 (en) * | 1996-02-22 | 1997-08-28 | The Du Pont Merck Pharmaceutical Company | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS |
WO1998028269A1 (en) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS |
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
WO1998057951A1 (en) * | 1997-06-19 | 1998-12-23 | Du Pont Pharmaceuticals Company | NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS |
WO1998057934A1 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550147A (en) | 1992-02-05 | 1996-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5563158A (en) | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
WO1997047299A1 (en) * | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
AU3110999A (en) * | 1998-03-27 | 1999-10-18 | Du Pont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
-
1999
- 1999-03-23 AU AU31109/99A patent/AU3110999A/en not_active Abandoned
- 1999-03-23 CA CA002321538A patent/CA2321538A1/en not_active Abandoned
- 1999-03-23 ES ES99912828T patent/ES2230841T3/en not_active Expired - Lifetime
- 1999-03-23 DE DE69920888T patent/DE69920888T2/en not_active Expired - Fee Related
- 1999-03-23 AT AT99912828T patent/ATE278673T1/en not_active IP Right Cessation
- 1999-03-23 EP EP99912828A patent/EP1064270B1/en not_active Expired - Lifetime
- 1999-03-23 WO PCT/US1999/006310 patent/WO1999050255A2/en active IP Right Grant
- 1999-03-23 JP JP2000541159A patent/JP2002509924A/en active Pending
- 1999-03-26 US US09/276,960 patent/US6191159B1/en not_active Expired - Lifetime
-
2000
- 2000-12-01 US US09/728,695 patent/US6436985B2/en not_active Expired - Lifetime
-
2002
- 2002-06-26 US US10/180,812 patent/US6630468B2/en not_active Expired - Lifetime
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5463071A (en) * | 1991-07-27 | 1995-10-31 | Dr. Karl Thomae Gmbh | 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
WO1995014682A1 (en) * | 1993-11-24 | 1995-06-01 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
WO1995014683A1 (en) * | 1993-11-24 | 1995-06-01 | The Du Pont Merck Pharmaceutical Company | Novel isoxazoline and isoxazole fibrinogen receptor antagonists |
WO1997023212A1 (en) * | 1995-12-21 | 1997-07-03 | The Du Pont Merck Pharmaceutical Company | ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS |
WO1997030971A1 (en) * | 1996-02-22 | 1997-08-28 | The Du Pont Merck Pharmaceutical Company | M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS |
WO1998028269A1 (en) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS |
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
WO1998057951A1 (en) * | 1997-06-19 | 1998-12-23 | Du Pont Pharmaceuticals Company | NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS |
WO1998057934A1 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
Also Published As
Publication number | Publication date |
---|---|
US6630468B2 (en) | 2003-10-07 |
ATE278673T1 (en) | 2004-10-15 |
EP1064270B1 (en) | 2004-10-06 |
CA2321538A1 (en) | 1999-10-07 |
EP1064270A2 (en) | 2001-01-03 |
WO1999050255A2 (en) | 1999-10-07 |
AU3110999A (en) | 1999-10-18 |
US6191159B1 (en) | 2001-02-20 |
DE69920888T2 (en) | 2006-02-02 |
US20030105105A1 (en) | 2003-06-05 |
JP2002509924A (en) | 2002-04-02 |
US6436985B2 (en) | 2002-08-20 |
DE69920888D1 (en) | 2004-11-11 |
US20010000179A1 (en) | 2001-04-05 |
ES2230841T3 (en) | 2005-05-01 |
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