WO1999051266A3 - Derivatives of pneumococcal choline binding proteins for vaccines - Google Patents

Derivatives of pneumococcal choline binding proteins for vaccines Download PDF

Info

Publication number
WO1999051266A3
WO1999051266A3 PCT/US1999/007680 US9907680W WO9951266A3 WO 1999051266 A3 WO1999051266 A3 WO 1999051266A3 US 9907680 W US9907680 W US 9907680W WO 9951266 A3 WO9951266 A3 WO 9951266A3
Authority
WO
WIPO (PCT)
Prior art keywords
choline binding
vaccines
derivatives
binding proteins
pneumococcal
Prior art date
Application number
PCT/US1999/007680
Other languages
French (fr)
Other versions
WO1999051266A2 (en
Inventor
Theresa M Wizemann
Scott Koenig
Leslie S Johnson
Original Assignee
Medimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99915326A priority Critical patent/EP1067962B1/en
Priority to AT99915326T priority patent/ATE461709T1/en
Application filed by Medimmune Inc filed Critical Medimmune Inc
Priority to CA002325340A priority patent/CA2325340A1/en
Priority to IL13879899A priority patent/IL138798A0/en
Priority to AU33869/99A priority patent/AU766455C/en
Priority to NZ507717A priority patent/NZ507717A/en
Priority to HU0102617A priority patent/HUP0102617A3/en
Priority to DE69942176T priority patent/DE69942176D1/en
Priority to JP2000542036A priority patent/JP2002510649A/en
Priority to PL99343544A priority patent/PL190188B1/en
Priority to BR9909483-5A priority patent/BR9909483A/en
Publication of WO1999051266A2 publication Critical patent/WO1999051266A2/en
Publication of WO1999051266A3 publication Critical patent/WO1999051266A3/en
Priority to IL138798A priority patent/IL138798A/en
Priority to NO20004972A priority patent/NO20004972L/en
Priority to AU2004200125A priority patent/AU2004200125B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

The present invention provides bacterial immunogenic agents for adminstration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species.
PCT/US1999/007680 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines WO1999051266A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP2000542036A JP2002510649A (en) 1998-04-07 1999-04-06 Vaccines and antibodies using pneumococcal choline binding protein derivatives
DE69942176T DE69942176D1 (en) 1998-04-07 1999-04-06 CHOLINE-BINDING PROTEIN DERIVATIVES FROM PNEUMOCOKES AS A VACCINE
CA002325340A CA2325340A1 (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines
AT99915326T ATE461709T1 (en) 1998-04-07 1999-04-06 CHOLINE-BINDING PROTEINS DERIVATIVES FROM PNEUMOCOCES AS VACCINES
AU33869/99A AU766455C (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines
NZ507717A NZ507717A (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines
PL99343544A PL190188B1 (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines
EP99915326A EP1067962B1 (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines
IL13879899A IL138798A0 (en) 1998-04-07 1999-04-06 Vaccines and antibodies against bacterial pneumococcal infection
HU0102617A HUP0102617A3 (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines
BR9909483-5A BR9909483A (en) 1998-04-07 1999-04-06 Choline pneumococcal binding protein derivatives for vaccines
IL138798A IL138798A (en) 1998-04-07 2000-09-29 Vaccines and antibodies against bacterial pneumococcal infection
NO20004972A NO20004972L (en) 1998-04-07 2000-10-03 Derivatives of pneumococcal choline binding proteins for vaccines
AU2004200125A AU2004200125B2 (en) 1998-04-07 2004-01-13 Derivatives of Pneumococcal Choline Binding Proteins for Vaccines

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8087898P 1998-04-07 1998-04-07
US60/080,878 1998-04-07
US8574398P 1998-05-15 1998-05-15
US60/085,743 1998-05-15

Publications (2)

Publication Number Publication Date
WO1999051266A2 WO1999051266A2 (en) 1999-10-14
WO1999051266A3 true WO1999051266A3 (en) 1999-12-09

Family

ID=26764078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/007680 WO1999051266A2 (en) 1998-04-07 1999-04-06 Derivatives of pneumococcal choline binding proteins for vaccines

Country Status (16)

Country Link
US (3) US6503511B1 (en)
EP (1) EP1067962B1 (en)
JP (1) JP2002510649A (en)
KR (2) KR100794394B1 (en)
CN (1) CN1200731C (en)
AT (1) ATE461709T1 (en)
AU (1) AU766455C (en)
BR (1) BR9909483A (en)
CA (1) CA2325340A1 (en)
DE (1) DE69942176D1 (en)
ES (1) ES2343492T3 (en)
HU (1) HUP0102617A3 (en)
IL (2) IL138798A0 (en)
NO (1) NO20004972L (en)
NZ (2) NZ507717A (en)
WO (1) WO1999051266A2 (en)

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US7078042B2 (en) * 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
US6858706B2 (en) * 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
WO1999051188A2 (en) * 1998-04-07 1999-10-14 St. Jude Children's Research Hospital A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
DE69942176D1 (en) * 1998-04-07 2010-05-06 Medimmune Llc CHOLINE-BINDING PROTEIN DERIVATIVES FROM PNEUMOCOKES AS A VACCINE
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
PT1163000E (en) 1999-03-19 2008-03-20 Glaxosmithkline Biolog Sa Vaccine against antigens from bacteriae
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
AU2001287645A1 (en) * 2000-07-20 2002-02-05 Hansa Medical Ab Fh-binding protein of streptococcus pneumiae
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US6674504B1 (en) 2000-09-29 2004-01-06 Kent Optronics, Inc. Single layer multi-state ultra-fast cholesteric liquid crystal device and the fabrication methods thereof
HUE029200T2 (en) 2002-08-02 2017-03-28 Glaxosmithkline Biologicals Sa Neisserial vaccine compositions comprising a combination of antigens
AU2003278166B2 (en) 2002-11-01 2009-01-29 Glaxosmithkline Biologicals S.A. Immunogenic composition
EP1667712B1 (en) 2003-10-02 2010-07-21 GlaxoSmithKline Biologicals S.A. B. pertussis antigens and use thereof in vaccination
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
US8052971B2 (en) * 2005-11-21 2011-11-08 MG Biologics Oral use of specific antibodies for intestinal health
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
AR058592A1 (en) 2005-12-22 2008-02-13 Glaxosmithkline Biolog Sa VACCINE
NZ569417A (en) 2006-01-17 2012-04-27 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein E; pE)
US8722055B2 (en) * 2006-09-27 2014-05-13 St. Jude Children's Research Hospital Synthetic Streptococcus pneumoniae vaccine
WO2009000825A2 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
JP5056490B2 (en) * 2008-03-10 2012-10-24 富士通株式会社 Distortion compensation coefficient updating apparatus and distortion compensation amplifier
EP2612680B1 (en) 2008-04-16 2018-05-23 GlaxoSmithKline Biologicals SA Vaccine
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
US9567377B2 (en) 2010-03-10 2017-02-14 Glaxosmithkline Biologicals Sa Immunogenic composition
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
JP6225104B2 (en) 2011-04-08 2017-11-01 タフツ メディカル センター インコーポレイテッドＴｕｆｔｓ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ，Ｉｎｃ． Design and use of pepducin
MX339058B (en) 2011-05-17 2016-05-09 Glaxosmithkline Biolog Sa Vaccine against streptococcus pneumoniae.
JP2014000016A (en) * 2012-06-15 2014-01-09 National Agriculture & Food Research Organization Novel antigenic protein of erysipelothrix rhusiopathiae, gene thereof, recombinant vector, and the use thereof
GB201318170D0 (en) * 2013-10-14 2013-11-27 Univ Edinburgh Proteins with Diagnostic and Therapeutic Uses
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
CA3005029A1 (en) 2015-11-13 2017-05-18 Oasis Pharmaceuticals, LLC Protease-activated receptor-2 modulators
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
JP7132954B2 (en) 2017-06-10 2022-09-07 インベントプライズ リミテッド ライアビリティ カンパニー Multivalent conjugate vaccines comprising bivalent or multivalent conjugated polysaccharides providing improved immunogenicity and avidity
GB201714478D0 (en) * 2017-09-08 2017-10-25 Univ Bristol Sensor

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Publication number Priority date Publication date Assignee Title
WO1997009994A1 (en) * 1995-09-15 1997-03-20 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
WO1997041151A2 (en) * 1996-05-01 1997-11-06 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998021337A2 (en) * 1996-11-12 1998-05-22 Regents Of The University Of Minnesota C3 BINDING PROTEIN OF $i(STREPTOCOCCUS PNEUMONIAE)

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BR9712900A (en) * 1996-11-06 2000-11-28 Univ California Isolated tumor necrosis factor receptor-releasing enzyme, compositions comprising the enzyme and methods of using it
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US6858706B2 (en) * 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
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WO1997041151A2 (en) * 1996-05-01 1997-11-06 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998021337A2 (en) * 1996-11-12 1998-05-22 Regents Of The University Of Minnesota C3 BINDING PROTEIN OF $i(STREPTOCOCCUS PNEUMONIAE)

Also Published As

Publication number Publication date
NO20004972L (en) 2000-12-05
IL138798A (en) 2008-11-03
US6503511B1 (en) 2003-01-07
ES2343492T3 (en) 2010-08-02
EP1067962B1 (en) 2010-03-24
CA2325340A1 (en) 1999-10-14
BR9909483A (en) 2001-10-09
HUP0102617A2 (en) 2001-11-28
US20050142145A1 (en) 2005-06-30
US20030138447A1 (en) 2003-07-24
KR20010034752A (en) 2001-04-25
ATE461709T1 (en) 2010-04-15
CN1315870A (en) 2001-10-03
AU766455B2 (en) 2003-10-16
IL138798A0 (en) 2001-10-31
CN1200731C (en) 2005-05-11
NZ530277A (en) 2005-08-26
WO1999051266A2 (en) 1999-10-14
HUP0102617A3 (en) 2006-04-28
AU766455C (en) 2004-12-02
US7435421B2 (en) 2008-10-14
US6863893B2 (en) 2005-03-08
JP2002510649A (en) 2002-04-09
EP1067962A2 (en) 2001-01-17
DE69942176D1 (en) 2010-05-06
AU3386999A (en) 1999-10-25
NO20004972D0 (en) 2000-10-03
KR20060126844A (en) 2006-12-08
KR100794394B1 (en) 2008-01-15
NZ507717A (en) 2004-02-27

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