WO1999056790A3 - 13c glucose breath test for the diagnosis of diabetes - Google Patents

13c glucose breath test for the diagnosis of diabetes Download PDF

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Publication number
WO1999056790A3
WO1999056790A3 PCT/IB1999/000933 IB9900933W WO9956790A3 WO 1999056790 A3 WO1999056790 A3 WO 1999056790A3 IB 9900933 W IB9900933 W IB 9900933W WO 9956790 A3 WO9956790 A3 WO 9956790A3
Authority
WO
WIPO (PCT)
Prior art keywords
breath test
diagnosis
diabetes
glucose breath
glucose
Prior art date
Application number
PCT/IB1999/000933
Other languages
French (fr)
Other versions
WO1999056790A2 (en
Inventor
Randall W Yatscoff
Robert T Foster
Launa J Aspeslet
Richard Lewanczuk
Original Assignee
Isotechnika Inc
Randall W Yatscoff
Robert T Foster
Launa J Aspeslet
Richard Lewanczuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc, Randall W Yatscoff, Robert T Foster, Launa J Aspeslet, Richard Lewanczuk filed Critical Isotechnika Inc
Priority to EP99919475A priority Critical patent/EP1075286A2/en
Priority to DE1075286T priority patent/DE1075286T1/en
Priority to US09/674,806 priority patent/US6468802B1/en
Priority to AU37251/99A priority patent/AU3725199A/en
Priority to CA002331812A priority patent/CA2331812C/en
Priority to JP2000546814A priority patent/JP2002513911A/en
Publication of WO1999056790A2 publication Critical patent/WO1999056790A2/en
Publication of WO1999056790A3 publication Critical patent/WO1999056790A3/en
Priority to US11/069,169 priority patent/US7118919B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104998—Glucose, ketone, nitrate standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25875—Gaseous sample or with change of physical state

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Atmospheric Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Obesity (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications and monitoring of glycemic control. The breath test utilizes the measurement of expired 13C-labeled CO¿2? following the ingestion of a ?13¿C-enriched glucose source.
PCT/IB1999/000933 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetes WO1999056790A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP99919475A EP1075286A2 (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetes
DE1075286T DE1075286T1 (en) 1998-05-06 1999-05-06 13C-glucose breath test to diagnose diabetes indications and monitor glycemic control
US09/674,806 US6468802B1 (en) 1998-05-06 1999-05-06 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
AU37251/99A AU3725199A (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetic indications andmonitoring glycemic control
CA002331812A CA2331812C (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
JP2000546814A JP2002513911A (en) 1998-05-06 1999-05-06 13C glucose breath test for diagnosis of diabetes symptoms and monitoring of blood sugar control
US11/069,169 US7118919B2 (en) 1998-05-06 2005-02-28 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8448298P 1998-05-06 1998-05-06
US60/084,482 1998-05-06

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US09/674,806 A-371-Of-International US6468802B1 (en) 1998-05-06 1999-05-06 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
US09674806 A-371-Of-International 1999-05-06
US09/910,701 Continuation-In-Part US6461870B2 (en) 1998-05-06 2001-07-20 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control
US10/228,276 Continuation US6602715B2 (en) 1998-05-06 2002-08-27 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control

Publications (2)

Publication Number Publication Date
WO1999056790A2 WO1999056790A2 (en) 1999-11-11
WO1999056790A3 true WO1999056790A3 (en) 1999-12-16

Family

ID=22185237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000933 WO1999056790A2 (en) 1998-05-06 1999-05-06 13c glucose breath test for the diagnosis of diabetes

Country Status (8)

Country Link
US (3) US6468802B1 (en)
EP (1) EP1075286A2 (en)
JP (3) JP2002513911A (en)
AU (1) AU3725199A (en)
CA (1) CA2331812C (en)
DE (1) DE1075286T1 (en)
ES (1) ES2161669T1 (en)
WO (1) WO1999056790A2 (en)

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US20050147560A1 (en) 2005-07-07
US6468802B1 (en) 2002-10-22
WO1999056790A2 (en) 1999-11-11
US7118919B2 (en) 2006-10-10
JP2008292506A (en) 2008-12-04
AU3725199A (en) 1999-11-23
CA2331812A1 (en) 1999-11-11
US6602715B2 (en) 2003-08-05
US20030044993A1 (en) 2003-03-06
EP1075286A2 (en) 2001-02-14
ES2161669T1 (en) 2001-12-16
JP2007192831A (en) 2007-08-02
JP2002513911A (en) 2002-05-14
DE1075286T1 (en) 2002-05-23

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