WO1999065490A3 - Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders - Google Patents

Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders Download PDF

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Publication number
WO1999065490A3
WO1999065490A3 PCT/US1999/013100 US9913100W WO9965490A3 WO 1999065490 A3 WO1999065490 A3 WO 1999065490A3 US 9913100 W US9913100 W US 9913100W WO 9965490 A3 WO9965490 A3 WO 9965490A3
Authority
WO
WIPO (PCT)
Prior art keywords
apnea
disorders
norcisapride
treatment
bulimia
Prior art date
Application number
PCT/US1999/013100
Other languages
French (fr)
Other versions
WO1999065490A2 (en
Inventor
Paul D Rubin
Timothy J Barberich
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000554370A priority Critical patent/JP2003522103A/en
Application filed by Sepracor Inc filed Critical Sepracor Inc
Priority to BR9911302-3A priority patent/BR9911302A/en
Priority to DE69924488T priority patent/DE69924488T2/en
Priority to AU46784/99A priority patent/AU764474B2/en
Priority to EP99930196A priority patent/EP1087765B1/en
Priority to KR1020007014025A priority patent/KR20010052740A/en
Priority to AT99930196T priority patent/ATE291916T1/en
Priority to IL14011799A priority patent/IL140117A0/en
Priority to SK1906-2000A priority patent/SK19062000A3/en
Priority to CA002334369A priority patent/CA2334369A1/en
Priority to HU0102026A priority patent/HUP0102026A3/en
Publication of WO1999065490A2 publication Critical patent/WO1999065490A2/en
Publication of WO1999065490A3 publication Critical patent/WO1999065490A3/en
Priority to IS5755A priority patent/IS5755A/en
Priority to NZ508825A priority patent/NZ508825A/en
Priority to NO20006358A priority patent/NO20006358L/en
Priority to BG105097A priority patent/BG105097A/en
Priority to HK02101726.7A priority patent/HK1040059A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods for the prevention, treatment, or management of apnea, apnea disorders, bulimia nervosa, irritable bowel syndrome, urinary incontinence, bradycardia, bradyarrhythmia, syncope, other disorders, or symptoms thereof using (-) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (+) stereoisomer.
PCT/US1999/013100 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders WO1999065490A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IL14011799A IL140117A0 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia and other disorders
AT99930196T ATE291916T1 (en) 1998-06-15 1999-06-10 USE OF OPTICALLY PURE (-) NORCISAPRIDE IN THE TREATMENT OF IRGITABLE BOWEL SYNDROME
BR9911302-3A BR9911302A (en) 1998-06-15 1999-06-10 Methods to treat bulimia, to treat disorders mediated by vagal activity, to treat irritable bowel syndrome, to treat apnea or apnea disorders, to prevent or control bulimia, disorders mediated by vagal activity, irritable bowel syndrome, bradycardia or bradyarrhythmia, asthma , urinary incontinence, and, apnea or apnea disorders in a patient
DE69924488T DE69924488T2 (en) 1998-06-15 1999-06-10 USE OF OPTICALLY PURE (-) NORCISAPRIDE IN THE TREATMENT OF REIZDARY SYNDROME
AU46784/99A AU764474B2 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders
EP99930196A EP1087765B1 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of irritable bowel syndrome
KR1020007014025A KR20010052740A (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia and other disorders
JP2000554370A JP2003522103A (en) 1998-06-15 1999-06-10 Use of optically pure (-)-norsis apide to treat apnea, bulimia and other disorders
HU0102026A HUP0102026A3 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride for producing pharmaceutical compositions suitable for treating apnea, bulimis, and other disorders
CA002334369A CA2334369A1 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders
SK1906-2000A SK19062000A3 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders
IS5755A IS5755A (en) 1998-06-15 2000-12-08 Use of pure light (-) narcotic epidermis in the treatment of respiratory arrest, bulimia and other injuries
NZ508825A NZ508825A (en) 1998-06-15 2000-12-12 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia and other disorders
NO20006358A NO20006358L (en) 1998-06-15 2000-12-13 Use of optically pure (-) - norcisapride in the treatment of apnea, bulimia and other diseases
BG105097A BG105097A (en) 1998-06-15 2000-12-27 Use of optically pure(-)norcisapride in the treatment of apnea, bulimia, and other disorders
HK02101726.7A HK1040059A1 (en) 1998-06-15 2002-03-06 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8922598P 1998-06-15 1998-06-15
US60/089,225 1998-06-15
US12223699P 1999-03-01 1999-03-01
US60/122,236 1999-03-01

Publications (2)

Publication Number Publication Date
WO1999065490A2 WO1999065490A2 (en) 1999-12-23
WO1999065490A3 true WO1999065490A3 (en) 2000-04-13

Family

ID=26780367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013100 WO1999065490A2 (en) 1998-06-15 1999-06-10 Use of optically pure (-) norcisapride in the treatment of apnea, bulimia, and other disorders

Country Status (24)

Country Link
US (2) US6559165B1 (en)
EP (1) EP1087765B1 (en)
JP (1) JP2003522103A (en)
KR (3) KR20060020739A (en)
CN (1) CN1312716A (en)
AR (1) AR020327A1 (en)
AT (1) ATE291916T1 (en)
AU (1) AU764474B2 (en)
BG (1) BG105097A (en)
BR (1) BR9911302A (en)
CA (1) CA2334369A1 (en)
CZ (1) CZ20004736A3 (en)
DE (1) DE69924488T2 (en)
ES (1) ES2237117T3 (en)
HK (1) HK1040059A1 (en)
HU (1) HUP0102026A3 (en)
IL (1) IL140117A0 (en)
IS (1) IS5755A (en)
NO (1) NO20006358L (en)
NZ (3) NZ526108A (en)
PL (1) PL345325A1 (en)
SK (1) SK19062000A3 (en)
TR (6) TR200103762T2 (en)
WO (1) WO1999065490A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160898B2 (en) 2001-12-14 2007-01-09 Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
US6362202B1 (en) * 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6835200B2 (en) 1999-06-22 2004-12-28 Ndo Surgical. Inc. Method and devices for tissue reconfiguration
US6821285B2 (en) 1999-06-22 2004-11-23 Ndo Surgical, Inc. Tissue reconfiguration
US7846180B2 (en) 1999-06-22 2010-12-07 Ethicon Endo-Surgery, Inc. Tissue fixation devices and methods of fixing tissue
US6663639B1 (en) 1999-06-22 2003-12-16 Ndo Surgical, Inc. Methods and devices for tissue reconfiguration
US8287554B2 (en) 1999-06-22 2012-10-16 Ethicon Endo-Surgery, Inc. Method and devices for tissue reconfiguration
EP1833467B1 (en) 2004-12-20 2016-08-03 Collegium Pharmaceutical, Inc. Pharmaceutical compositions for sleep disorders
GB0524668D0 (en) * 2005-12-02 2006-01-11 Novartis Ag Organic compounds
US8852216B2 (en) 2007-03-23 2014-10-07 Ethicon Endo-Surgery, Inc. Tissue approximation methods

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0364274A1 (en) * 1988-10-13 1990-04-18 Glaxo Group Limited Imidazole derivatives
WO1993012785A1 (en) * 1991-12-21 1993-07-08 Smithkline Beecham Plc Use of 5-ht4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
WO1994027599A1 (en) * 1993-05-25 1994-12-08 Laboratoires Glaxo Wellcome S.A. Rectal compositions
EP0748807A1 (en) * 1995-06-13 1996-12-18 Synthelabo Derivatives of N-(1,4-diazabicyclo(2.2.2)-oct-2-yl)methyl benzamide, their preparation and their therapeutical use
WO1996040133A1 (en) * 1995-06-07 1996-12-19 Sepracor Inc. Optically pure (-) norcisapride for treating digestive tract disorders
WO1998003173A1 (en) * 1996-07-19 1998-01-29 Sepracor Inc. Methods for treating emesis and central nervous system disorders using optically pure (+) norcisapride
WO1999002496A1 (en) * 1997-07-11 1999-01-21 Janssen Pharmaceutica N.V. (+)-norcisapride useful for 5-ht3 and 5-ht4 mediated disorders

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR748807A (en) 1932-03-10 1933-07-10 Gulf Refining Co Improvements in the manufacture of hydrocarbons
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4962115A (en) 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5137896A (en) 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CA1183847A (en) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5057525A (en) 1981-10-01 1991-10-15 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives
US4598123A (en) 1983-07-14 1986-07-01 Unites States Steel Corporation Impact modified methyl methacrylate polymer
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4800162A (en) 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
US5057427A (en) 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5116407A (en) 1988-10-13 1992-05-26 Courtaulds Coatings Limited Antifouling coatings
JPH02188523A (en) 1989-01-13 1990-07-24 M S C:Kk Remedy for apnea in sleeping
IT1229203B (en) 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
US5075290A (en) 1989-06-28 1991-12-24 University Of Virginia Alumni Patents Foundation Use of adenosine, adenosine analogs or nucleoside uptake blockers, e.g. dipyridamole, as drug treatments for obstructive sleep apnea and snoring
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5356934A (en) 1990-03-29 1994-10-18 Eli Lilly And Company Selected serotonin subtype receptor agonist to treat sleep apnea
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
AU4666393A (en) 1992-07-07 1994-01-31 Sepracor, Inc. Methods of using (-) cisapride for the treatment of gastro-esophageal reflux disease and other disorders
EP1170010A3 (en) 1992-07-07 2004-05-19 Sepracor Inc. Method of using (+) cisapride for the treatment of gastro-esophageal reflux disease and other disorders
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
WO1995001803A1 (en) 1993-07-06 1995-01-19 Merck & Co., Inc. H2 antagonist-gastrointestinal motility agent combinations
US5407953A (en) 1994-02-04 1995-04-18 Morgan; Julia A. Treating apnea/hypopnea/snoring in humans
US5502067A (en) 1994-02-04 1996-03-26 Morgan; Julia A. Treating apneahypopnea/snoring in humans
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
SI1089733T1 (en) 1998-06-15 2005-06-30 Sepracor Inc. Use of optically pure (+)-norcisapride for treating irritable bowel syndrome

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0364274A1 (en) * 1988-10-13 1990-04-18 Glaxo Group Limited Imidazole derivatives
WO1993012785A1 (en) * 1991-12-21 1993-07-08 Smithkline Beecham Plc Use of 5-ht4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
WO1994027599A1 (en) * 1993-05-25 1994-12-08 Laboratoires Glaxo Wellcome S.A. Rectal compositions
WO1996040133A1 (en) * 1995-06-07 1996-12-19 Sepracor Inc. Optically pure (-) norcisapride for treating digestive tract disorders
EP0748807A1 (en) * 1995-06-13 1996-12-18 Synthelabo Derivatives of N-(1,4-diazabicyclo(2.2.2)-oct-2-yl)methyl benzamide, their preparation and their therapeutical use
WO1998003173A1 (en) * 1996-07-19 1998-01-29 Sepracor Inc. Methods for treating emesis and central nervous system disorders using optically pure (+) norcisapride
WO1999002496A1 (en) * 1997-07-11 1999-01-21 Janssen Pharmaceutica N.V. (+)-norcisapride useful for 5-ht3 and 5-ht4 mediated disorders

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BLECKER U. ET AL: "The role of ' occult ' gastroesophageal reflux in chronic pulmonary disease in children.", ACTA GASTRO-ENTEROLOGICA BELGICA, (1995) 58/5-6 (348-352)., XP002128488 *
NOOR N ET AL: "Effects of cisapride on symptoms and postcibal small-bowel motor function in patients with irritable bowel syndrome.", SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, (1998 JUN) 33 (6) 605-11., XP002128489 *
SHAH M.: "Gastroesophageal reflux - How to mend it?.", INDIAN JOURNAL OF PEDIATRICS, (1996) 63/4 (441-445)., XP002128487 *
SKINNER S ET AL: "Gastric ulcer presenting as gastroesophageal reflux and apnea in a term neonate.", TEXAS MEDICINE, (1998 SEP) 94 (9) 57-8., XP002128490 *
VANDENPLAS Y: "Clinical use of cisapride and its risk-benefit in paediatric patients.", EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, (1998 OCT) 10 (10) 871-81. REF: 106, XP002128486 *
WARD R M ET AL: "Cisapride: a survey of the frequency of use and adverse events in premature newborns.", PEDIATRICS, (1999 FEB) 103 (2) 469-72., XP002128485 *

Also Published As

Publication number Publication date
HUP0102026A2 (en) 2001-11-28
NZ508825A (en) 2003-09-26
CN1312716A (en) 2001-09-12
AR020327A1 (en) 2002-05-08
CA2334369A1 (en) 1999-12-23
NO20006358L (en) 2001-02-13
CZ20004736A3 (en) 2001-09-12
IS5755A (en) 2000-12-08
BG105097A (en) 2002-02-28
US20030158229A1 (en) 2003-08-21
TR200003707T2 (en) 2001-06-21
IL140117A0 (en) 2002-02-10
TR200103762T2 (en) 2002-05-21
TR200103760T2 (en) 2002-06-21
NZ526108A (en) 2004-10-29
EP1087765B1 (en) 2005-03-30
HK1040059A1 (en) 2002-05-24
KR20060067985A (en) 2006-06-20
TR200103758T2 (en) 2002-06-21
AU764474B2 (en) 2003-08-21
NZ535055A (en) 2006-04-28
JP2003522103A (en) 2003-07-22
DE69924488D1 (en) 2005-05-04
EP1087765A2 (en) 2001-04-04
ES2237117T3 (en) 2005-07-16
ATE291916T1 (en) 2005-04-15
TR200103759T2 (en) 2002-06-21
SK19062000A3 (en) 2001-07-10
US6559165B1 (en) 2003-05-06
TR200103757T2 (en) 2002-06-21
PL345325A1 (en) 2001-12-17
KR20060020739A (en) 2006-03-06
NO20006358D0 (en) 2000-12-13
DE69924488T2 (en) 2005-09-08
BR9911302A (en) 2001-03-13
KR20010052740A (en) 2001-06-25
WO1999065490A2 (en) 1999-12-23
HUP0102026A3 (en) 2002-12-28
US7064138B2 (en) 2006-06-20
AU4678499A (en) 2000-01-05

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