WO1999066959A3 - Compositions and methods for delivery of genetic material for altering neuronal growth, regeneration, and survival - Google Patents

Compositions and methods for delivery of genetic material for altering neuronal growth, regeneration, and survival Download PDF

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Publication number
WO1999066959A3
WO1999066959A3 PCT/US1999/012126 US9912126W WO9966959A3 WO 1999066959 A3 WO1999066959 A3 WO 1999066959A3 US 9912126 W US9912126 W US 9912126W WO 9966959 A3 WO9966959 A3 WO 9966959A3
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WO
WIPO (PCT)
Prior art keywords
methods
compositions
delivery
regeneration
survival
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Application number
PCT/US1999/012126
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French (fr)
Other versions
WO1999066959A9 (en
WO1999066959A2 (en
Inventor
Andrew Baird
Martin Berry
Ann Logan
Ana Maria Gonzalez
Original Assignee
Selective Genetics Inc
Andrew Baird
Martin Berry
Ann Logan
Ana Maria Gonzalez
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Publication date
Application filed by Selective Genetics Inc, Andrew Baird, Martin Berry, Ann Logan, Ana Maria Gonzalez filed Critical Selective Genetics Inc
Priority to CA002330026A priority Critical patent/CA2330026A1/en
Priority to AU62380/99A priority patent/AU765436B2/en
Priority to JP2000555645A priority patent/JP2002518464A/en
Priority to EP99949529A priority patent/EP1082142A2/en
Publication of WO1999066959A2 publication Critical patent/WO1999066959A2/en
Publication of WO1999066959A9 publication Critical patent/WO1999066959A9/en
Publication of WO1999066959A3 publication Critical patent/WO1999066959A3/en

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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Abstract

Devices useful in the delivery of DNA encoding neurotrophic agents, antifibrotic agents, and related compositions are disclosed herein for use in the treatment of central and/or peripheral nervous system injury. Methods of making and using the disclosed devices and DNA are also described. In various embodiments, the invention also discloses compositions and devices that may further include a targeting agent, such as a polypeptide that is reactive with an FGF receptor (e.g., bFGF), or another ligand that binds to cell surface receptors on neuronal cells, or a support cell. The invention also discloses methods of promoting neuronal survival and regeneration via transfection of an axon as it grows through a device or composition of the present invention, or via transfection of a repair cell.
PCT/US1999/012126 1998-06-01 1999-06-01 Compositions and methods for delivery of genetic material for altering neuronal growth, regeneration, and survival WO1999066959A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002330026A CA2330026A1 (en) 1998-06-01 1999-06-01 Compositions and methods for delivery of agents for altering neuronal growth, regeneration, and survival
AU62380/99A AU765436B2 (en) 1998-06-01 1999-06-01 Compositions and methods for delivery of agents for altering neuronal growth, regeneration, and survival
JP2000555645A JP2002518464A (en) 1998-06-01 1999-06-01 Compositions and methods for delivery of factors to alter neuronal growth, regeneration, and survival
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