WO2000000282A1 - Basic clay catalyst for the production of glycol monoester - Google Patents
Basic clay catalyst for the production of glycol monoester Download PDFInfo
- Publication number
- WO2000000282A1 WO2000000282A1 PCT/US1999/014786 US9914786W WO0000282A1 WO 2000000282 A1 WO2000000282 A1 WO 2000000282A1 US 9914786 W US9914786 W US 9914786W WO 0000282 A1 WO0000282 A1 WO 0000282A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- clay
- base
- modified
- modified clay
- percent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
- C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
- B01J21/16—Clays or other mineral silicates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
- C07C29/175—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with simultaneous reduction of an oxo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/44—Preparation of carboxylic acid esters by oxidation-reduction of aldehydes, e.g. Tishchenko reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C11/00—Fermentation processes for beer
- C12C11/02—Pitching yeast
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/02—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the alkali- or alkaline earth metals or beryllium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Definitions
- the invention relates to methods for the preparation of glycol monoesters from aldehydes using a base-modified clay as a catalyst. More particularly, the invention relates to base-modified clays that catalyze aldol condensations and Tischenko hydride shifts while minimizing side reactions such as transesterif ⁇ cations .
- Glycol monoesters are compounds having the following structure, where R 1 and R 2 are each either hydrogen or an organic group (e.g., an alkyl group):
- glycol monoesters are used as industrial intermediates, solvents, plasticizers for polyvinylchloride and polyolefms, and coalescing aids for latex paints.
- One well-known glycol monoester is a product from 2-methyl propionaldehyde, where both R 1 and R 2 in the above formula are methyl groups, which is sold under the TEXANOL® trade name by Eastman Chemical Company, Kingsport, Tennessee.
- the TEXANOL® product is the premier coalescing aid and leveling agent for latex paints and is also used as a plasticizer for polyvinylchloride products.
- glycol monoesters from aldehydes is well known in the art.
- a typical process for forming glycol monoesters begins with an aldol condensation of an aldehyde having an alpha-hydrogen followed by a Tischenko hydride shift.
- Scheme I depicts these reactions, including the formation of a dioxanol intermediate.
- glycol monoester depicts the ester in the 1 -position
- the glycol monoester actually exists as a mixture of the 1- and 3- isomers. These isomers interconvert through an equilibrium (shown in scheme II) at sufficiently high temperature, in the presence of a catalyst, or over time.
- glycol monoesters Additional by-products in the preparation of glycol monoesters are glycol, glycol diester and alcohol. These by-products result from transesterifications, as shown in schemes V-VII:
- the extent of transesterification is generally related to the temperature and the reaction conditions for the aldehyde conversion. Under low simple ester production conditions, the limiting values of the transesterification keep the glycol : glycol monoester : glycol diester ratio near 1:2:1 so that the maximum yield of the glycol monoester is 50 percent. At high simple ester production conditions, the glycol : glycol monoester : glycol diester ratio becomes skewed toward the glycol diester as the simple ester transfers its ester group to the glycol derivatives releasing the alcohol. At high simple ester production conditions coupled with the limiting transesterification conditions, the yield of the glycol monoester may fall significantly below 50 percent.
- glycol monoesters Because significant amounts of by-products often result, processes to prepare glycol monoesters require elaborate and costly purification schemes to separate the product from the by-products and to reconvert the by-products into glycol monoesters. Processes requiring over one dozen distillation columns and two or more reactors are not uncommon. Thus, a need exists for an improved glycol monoester synthesis. A further need exists for a catalyst that promotes aldol condensations and Tischenko hydride shifts to produce glycol monoesters while minimizing unwanted by-products.
- a base-modified clay of the invention catalyzes the reaction underlying this new process.
- Use of a base-modified clay according to the invention selectively catalyzes the reaction and advantageously minimizes, or even eliminates, unwanted by-products.
- One embodiment of the invention is a base-modified clay that catalyzes the formation of a glycol monoester from an aldehyde.
- the base-modified clay has secluded conjugate base sites and exchangeable interstitial cationic spaces.
- all interstitial hydroxyl groups of the clay have been converted to oxide sites, at least one structural hydroxyl group has been converted to an oxide site, and the clay contains sufficient conjugate base cations to balance the charge of said oxide groups.
- Another embodiment is a process for preparing the base-modified clay.
- the process includes heating a clay in a basic solution under conditions sufficient to produce a clay having secluded conjugate base sites and exchangeable interstitial cationic spaces.
- Yet another embodiment of the invention provides a process for preparing a glycol monoester.
- This process includes heating in a reaction vessel an aldehyde and a catalytic amount of a base-modified clay under conditions sufficient to produce a glycol monoester.
- the aldehyde has formula:
- R 1 and R 2 are independently selected from the group consisting of H, C,. 2 o alkyl, C 2-2 o alkenyl, C 2 . 20 alkynyl, C 3 . 20 cycloalkyl, and aryl; and the glycol monoester has a formula:
- Figure 1 depicts TMPD isobutyrate selectivity as a function of isobutyraldehyde for several catalysts.
- Figure 2 depicts the monoester glycol yields for the reaction of 2-methyl propanal using a sodium isobutoxide catalyst.
- a glycol monoester is prepared by a process using a base-modified clay to catalyze the conversion of an aldehyde having an alpha- hydrogen to a glycol monoester via an aldol condensation followed by a Tischenko hydride shift.
- This reaction is shown in scheme VUI: R 2 O R 2 OH R 2 O R 1 catalyst I I I II I
- the invention relates to a base-modified clay having secluded conjugate base sites and exchangeable interstitial cationic spaces.
- all interstitial hydroxyl groups have been converted to oxide sites, at least one structural hydroxyl group has been converted to an oxide site, and the modified clay contains sufficient conjugate base cations to balance the charge of the oxide sites.
- the base-modified clay contains an actual number of sites per unit cell where an alkali metal or other base cation has been exchanged for the hydroxyl proton that exceeds a calculated number of exchangeable sites per unit cell in the unmodified clay.
- Clays encompasses not only clays, but also similar exchangeable minerals.
- Clays are generally microcrystalline, semi-microcrystalline, or amorphous mineral compounds of hydrated silicas and hydrated alumina, magnesias, iron oxides, and/or minor amounts of various other elements many of which exist as point impurities in the silica, alumina, magnesia, and/or iron oxide phases.
- Clays that are particularly useful in practicing the invention are the layered and exchangeable smectite clays, the partially exchangeable and hydrated illite clays, the hydrated chlorites, and other minerals with expandable and exchangeable interstitial cation spaces.
- These clays include, but are not limited to, montmorillonites, beidellites, nontronites, saponites, stevensites, sepiolite- palygorskites and hectorites, so-called degraded illites, hydrated chlorites, micas and other exchangeable and solvatable minerals including brucites, aluminas and silica gels.
- Clays are typically acidic in their naturally occurring state. Because this acidity would catalyze undesirable side reactions, the clays of the invention are modified by treating them with a basic cation-containing solution.
- the acidic or basic character of a particular clay depends largely on the nature of the water of hydration.
- the water may exist as structurally bound hyrdoxyl groups (OH groups) as well as loosely bound H 2 O. While intending not to be bound by any particular theory, it is believed that this base-modification serves two purposes. First, it neutralizes substantially all of the acid sites (OH sites) within the clay and replaces them with their conjugate basic sites (O ). Second, the treatment impregnates or dopes the clay with cations from the base.
- the base-modified clays of the invention can generally be characterized by the following properties.
- the crystalline fraction and the crystallographic structure, as shown by X-ray analysis, remains the same between the unmodified clay and the cation-doped clay.
- the ratios of the framework atoms, such as Si, Al, Mg, and Fe for the cation-doped clay remains substantially the same as the unmodified clay.
- the base cation is present in the base-modified clay in a concentration ranging from about 0.005 to about 20 weight percent, preferably from about 0.1 to about 15 weight percent, and even more preferably 0.5 to 10 percent weight.
- the catalyst activity remains low since the number of active sites is correspondingly small.
- the clay acts more and more like a homogeneous base catalyst, and the catalyst selectivity for only primary aldol / Tischenko products diminishes.
- the cation present is in the form of chemically bound ions, not merely adsorbed, because they remain in the catalyst after repeated washings with solvent.
- the basified clays display unusual basic properties deriving from the location of the base within the highly inaccessible interior of the clay's layer structure and occurring in addition to typical base properties provided by base sites within the readily accessible interstitial cavity or at the clay's surface. It is believed that under the forcing conditions of the catalyst preparation, the unusual base properties form when the reagent base anions penetrate the interior of the clay's layer structure converting the sequestered acidic structural hydroxyl (OH) groups into their Bronstead conjugate base form, oxide (O-) groups.
- the cationic counterions remain separate, largely within the interstitial cavity bound by ionic forces in order to balance charge but physically too large to fit into the clay's layer structure unless the outer shell of the clay layer is otherwise disrupted. It is believed that the resulting forced charge separation serves to further increase the basicity and further enhance the unusual basic properties. It is also believed that the number of basic sites, and thus the activity, and is directly proportionate to and therefore indicated by the amount of cation contained within the catalyst.
- lithium is an anomalous exception to basified clays described above due to its small size and propensity to form less ionic or covalent bonds. It is believed that the lithium cation may penetrate the clay's layer structure along with the base anion converting hydroxyl (OH) groups into tightly bound lithium oxide ion pairs, (OLi) groups, and displacing other ions especially in the octahedral layer sites. It is believed that this pervasive infusion explains why lithium loadings are often 2-4 times larger than other metal cations on a gram atom basis.
- the base-modified clay contains sufficient metal cations to balance the charge of all oxide sites within the clay.
- Suitable metal cations include alkaline metals, such as the group 1 alkali metals, the group 2 alkaline earth metals, and various other metals, such as zinc, cesium, rubidium, and thallium.
- Preferred counterions are sodium, potassium and lithium.
- a base-modified clay may have a mixture of metal cations.
- a base-modified clay of the invention should have greater than or equal to 1.2 metal cations per unit cell. The number of metal cations per unit cell will vary depending on the metal used in the base-modification. The amount of metal cation in the clay can be readily determined by elemental analysis or other techniques known on the art.
- the amount of base-modification can be readily determined by comparing the elemental analysis of the starting clay and that of the base-modified clay.
- concentration of metal cation in the base-modified clay should be greater than about 0.005 weight percent; more preferably, greater than about 0.1 weight percent; and most preferably, greater than 1 weight percent.
- Sodium-modified clays for example, can have up to three or more sodium cations per unit cell giving a sodium concentration of 8 to 9 weight percent.
- Lithium-modified clays have been found to have high concentrations of lithium cations. Lithium-modified clays have up to twelve lithium cations per unit cell. The lithium cation concentration may be as high as 10 weight percent in the base-modified clay. Preferably, the lithium cation concentration ranges from 0.1 to 15, and more preferably from 0.5 to 12.
- Preferred base-modified clays of the invention not only have secluded conjugate base sites but also have cavities or spaces penetratable by the organic substrate adjacent to the base sites.
- the cavities preferably have a gallery width that is less than about 10.2 A, as determined by the X-ray do ⁇ spacing and the clay layer width. More preferably, the gallery width ranges from about 9 A to about 10.2 A. It is also preferable that the cavities are wettable. Unwettable clays with neutral hydrophobic cavities, such as the talcs, or with highly charged cavities having tightly complexing counterions, such as the micas, are generally unsuitable.
- the base-modified clay can be used in various forms to catalyze chemical reactions such as those described below.
- the invention relates to a catalyst composition
- a catalyst composition comprising a base-modified clay as described above.
- the base-modified clay can be formed into granules, particles, pellets, spheres, tablets, rings, or extrudates and placed into a fixed bed reactor, as is known in the art.
- the minimum dimension of the catalyst is greater than about 0.02 inches.
- the reactants are passed over the catalyst bed and the crude product is collected at the other end.
- the catalyst can be stirred with the reactants as a slurry and the crude product separated from the catalyst by filtration, gravity settling, or centrifugation. In either case, the fact that the catalyst is a solid material and substantially insoluble in the reaction medium makes separation of the catalyst straightforward. It also avoids many costly environmental problems that are associated with the treatment and disposal of aqueous waste streams containing excess soluble base catalysts.
- Another embodiment of the invention is a process for preparing a base- modified clay.
- the clay is treated with a basic solution of a compound having a basic anion or an uncharged species capable of abstracting a proton from a hydroxyl group within the clay under conditions sufficient to produce a clay having secluded conjugate base sites and exchangeable interstitial cationic spaces.
- the species which extracts the hydroxyl group may, as explained below, be generated after the clay is treated with the compound.
- the solution may include either salts of a basic anion or other uncharged species in a solvent or as a neat liquid.
- the basic cation is preferably an alkaline metal cation from group 1 or 2 of the periodic table or other suitable metal cation.
- Suitable basic anions include, but are not limited to, hydroxide, amide, carbonate, silicate, metasilicate, phosphate, cyanide, borate, tetraborate, hydride, and aluminate.
- Suitable uncharged species include, but are not limited to, ammonia, amines, molten alkali metals, and alkali metal amalgams.
- Additional basic anions useful in the invention include other anions that are not intrinsically basic but that can be made basic with further treatment. Mixtures of basic compounds may be used in the base-modification to give a base-modified clay have a mixture of metal cations.
- the solvent used in the preparation of the base-modified clays is not critical, provided its dielectric constant or complexing ability is high enough to serve as a solvent for both the entering basic moiety and the leaving cation and provided that it thoroughly wets the clay. Wetting is important for good base exchange.
- Suitable solvents include, but are not limited to, water, anhydrous ammonia, aqueous ammonia, and polar organic solvents such as ethers, alcohols, amines, ketones, dimethyl sulfoxide, and dimethyl formamide.
- Preferred solvents include liquid ammonia, dimethyl formamide and, more preferably, water.
- One method of preparing a base-modified clay wherein the clay is heated, for example, with stirring, at reflux, and/or under pressure, in a basic solution for a sufficient amount of time to convert acidic hydroxyl (OH) sites, including interstitial and at least one structural hydroxyls, to oxide sites (O ).
- the oxide sites are the conjugate bases of the acidic hydroxyl sites.
- the process includes heating a slurry of a clay, for example, with stirring, at reflux, and/or, under pressure, in a basic solution for an amount of time sufficient to effect an exchange of a base for substantially all acidic sites on the surfaces of the clay. More preferably, the heating should continue until all interstitial hydroxyl groups of the clay have been converted to oxide sites and at least one structural hydroxyl group has been converted to an oxide site.
- the reaction conditions for preparation of the base-modified clay are not critical. Generally, however, the temperature should be within the range of about 0 °C and about 500 °C, preferably about 40 °C and about 120 °C. Likewise, the reaction time is not critical, but generally ranges from about 0.5 h to about 100 h, preferably at least 6 h. If the heating time is too short, an insufficient of base- modification will take place. If it is too long, the clay may begin to decay or even decompose.
- the ratio of basic solution to clay should be greater than about 1:10 by weight. Preferably the ratio ranges from about 2:1 to about 100: 1.
- the conversion of acidic hydroxyl (OH) sites, including interstitial and at least one structural hydroxyls, to oxide sites (O ) can be accomplished by heating, for example, with stirring, at reflux, and/or under pressure, for about 4 to 24 hours in a 5-50 percent preferably 10-30 percent aqueous solution of a Br ⁇ nsted base. As long as the base is present in large excess, the actual concentration is not critical although lower concentration may require longer heating times. Heating times will vary depending on the particular clay and the number of hydroxyl groups to be converted.
- the base-modified clay may be prepared by heating the clay, for example, with stirring, at reflux, and/or under pressure, for 6 to 12 hours in a 5-50 percent aqueous solution of an alkaline hydroxide, such as sodium hydroxide, lithium hydroxide, potassium hydroxide, magnesium hydroxide, calcium hydroxide and the like.
- an alkaline hydroxide such as sodium hydroxide, lithium hydroxide, potassium hydroxide, magnesium hydroxide, calcium hydroxide and the like.
- a base-modified clay of the invention may also be prepared by mixing the clay with a solution of a salt or other compound having an alkaline metal in combination with a species that undergoes combustion or pyrolysis to yield a basic species capable of extracting a proton from a hydroxyl group within the clay.
- a stoichiometric excess of the salt or other compound is first dissolved in an appropriate solvent and then mixed with the clay to treat the clay introducing the salt or other compound into the clay structure. The solvent is then removed or the clay isolated (e.g. by filtration) and the treated clay subjected to pyrolysis and /or combustion.
- Suitable salts and other compounds for this pyrolysis or combustion technique include, but are not limited to, carbonate, bicarbonate, nitrate, nitrite, azide, aliphatic and aromatic carboxylates, phenoxides, unsubstituted and substituted cyclopentadienes, and 1,3-dicarbonyl derivatives.
- alkaline earth hydroxides which have poor solubility in water.
- a soluble form of the cation can be dissolved in a solvent, intimately mixed with the clay, then the treated clay is subjected, for example, to pyrolysis or a combustion / pyrolysis process at 150 °C to 1250 °C, thereby releasing small, neutral molecules which are often anhydrides of inorganic acids.
- the acid anhydrides then react with the hydroxyl sites in the clay affecting the desired base- modification.
- a metal carbonate would decompose emitting carbon dioxide which, under oxidizing conditions, yields an oxide to extract the hydroxyl proton and, thereby, affecting the basic modification of the clay.
- Nitrates similarly decompose to an oxide under oxidative conditions.
- the clay should be heated to a temperature less than its fusing temperature, avoiding a change in molecular structure of the clay. Preferred temperatures ranges from about 300 °C to 500 °C, particularly for clays having a fusing temperature at or just above 600 °C.
- Another embodiment of the invention is a process for preparing a glycol monoester by reacting at least one aldehyde in the presence of a base-modified clay.
- This process includes heating, for example, with stirring, at reflux, and/or under pressure, in a reaction vessel the aldehyde(s) and the base-modified clay under conditions sufficient to produce a glycol monoester.
- the overall reaction of this process is shown in scheme VIII:
- R 1 and R 2 is each independently selected from the group consisting of H, C 1-20 alkyl, C 2 . 20 alkenyl, C 2 . 20 alkynyl, C 3 . 20 cycloalkyl, and aryl. Where R, or R 2 is an alkyl, alkenyl, alkynyl, cycloalkyl groups may be straight or branched, or unsubstituted or substituted.
- Preferred aldehydes are 2-alkylpropanals, 2- alkylbutanals, 2-alkylpentanals, and 2-alkylhexanals.
- glycol monoester As many as three different aldehydes can be used to form a glycol monoester. Mixtures of more than one aldehyde will produce a mixture of glycol monoester products. Generally, it is more economically desirable to produce a single glycol monoester product. It is therefore preferred to prepare a glycol monoester according to the invention from only one aldehyde reactant.
- the at least one aldehyde is in the liquid phase and can be heated, for example, with stirring, at reflux, and/or under pressure, with the base-modified clay catalyst.
- the aldehyde is present in an excess amount and acts as the solvent for the reaction, thereby obviating the need of a separate solvent.
- the temperature typically ranges from about 30 °C to 400 °C, preferably from about 50 °C to 250 °C. The temperature should not be so high as to degrade the starting aldehyde or the glycol monoester product. It is also preferable to reflux the mixture in an inert atmosphere to prevent undesired reactions with the air.
- preparing a glycol monoester using a base-modified clay catalyst of the invention does not require the same rigorous inert conditions as needed with other syntheses.
- the weight ratio of aldehyde to catalyst can range from about 1000:1 to 0.1 to 1 , and preferably from 100: 1 to 1 : 1. More preferably, the weight ratio is about 40:1.
- the process of the invention typically affords the desired glycol monoester in yields exceeding 85% under normal aldehyde conversion ranging from 30 to 98+ %. Yields of 95 % or greater can be achieved with aldehyde conversions of 50 to 98+ %.
- an organic solvent may be used to make the phases of the reaction mixture miscible.
- solvents include, but are not limited to, ethers, cyclic ethers, alcohols, amines, ketones, dimethyl sulfoxide, dimethyl formamide, or mixtures thereof.
- the organic solvent is an ether of formula R 6 OR 7 , where R 6 and R 7 are selected from the group consisting of hydrocarbyl moieties having from 1 to 12 carbon atoms or together form a cycloalkyl or cycloalkenyl moiety having from 3 to 12 carbon atoms.
- the organic solvent is tetrahydrofuran, tetrahydropyran, methanol, ethanol, propanal, isopropanal, or diethyl ether.
- the organic solvent should preferably be added in a large enough amount that the reaction mixture remains homogeneous throughout the course of the reaction, yet small enough that the reactants are not diluted to the point of slowing down the reaction.
- the amount of organic solvent ranges from 0 to about 75 % by weight.
- the preferred range for typical carbonyl-containing reactants is 5 to 50 % by weight with 10 to 40 % by weight being especially preferred.
- the catalyst functions as a base in the same way that any base known in the prior art functions.
- the base functionalities are sequestered in the catalyst cavities so that access to them is limited. Consequently, steric crowding in the rate determining transition state limits participation of that reaction to the final product mix.
- the sequestering changes the nature of the base so that it forms covalent bonds poorly. In these cases, large spatial requirements for the transition state are disfavored as are species requiring covalent bonding to the base site.
- the base site incorporated into the catalyst wall starts the Tischenko conversion by reversibly removing a proton from the dioxanol OH group.
- This dioxanalkoxide breaks down into an acyclic aldol hemiacetal conjugate base.
- Rotation of the H into the location formerly occupied by the Q: sets the stage for the hydride shift to the carbonyl C. Pushed by the negative charge on the O and pulled by the HO conjugate acid site on the catalyst cavity wall, the hydride shift takes place irreversibly.
- the size of this transition species depends on the size of the R groups. But in the case where R is methyl or some other primary alkyl group, the minimum diameter of the transition state is about 6.8 Angstrom units. Since the gallery width of montmorillonite is 9.6 Angstroms with no polar molecules in the cavity according to Grim, R.E., "Applied Clay Mineralogy,” McGraw-Hill (1962), 307- 20, there is enough room to accommodate this transition state and the reaction can physically take place.
- the spatial requirements of the intermediate dioxanol rearranging to form the glycol monoester is shown in Scheme IX:
- the simple ester product forms by a Tischenko / Cannizzarro reaction.
- the transition state contains only two aldehyde units and is smaller than the transition state forming the glycol monoester. So size constraints for the transition state in the critical dimension are not important.
- the equipment for this experiment was a 500 milliliter round bottom flask equipped with a magnetic stirring bar, a thermowell to momtor the internal reaction temperature, and a reflux condenser topped with a nitrogen bubbler used to maintain a nitrogen blanket over the flask contents throughout the reaction.
- the yields of the aldol / Tischenko / Cannizzarro products were 3.2 percent Glycol Monoester (2,2,4-trimethyl-3- hydroxy-1-pentyl 2-methylpropanoate), 0.1 percent Glycol (2,2,4-trimethyl-l,3- pentanediol), 0.0 percent Glycol Diester (2,2,4-trimethyl-l,3-pentane di-(2- methylpropanoate)), 0.3 percent Simple Ester (2-methyl- 1-propyl 2- methylpropanoate), and 0.3 percent Alcohol (2-methyl- 1-propanol).
- the most abundant single product was 2,4,6-tri-(2-methylethyl)-l,3,5-trioxane in 15.8 percent yield.
- Example 2 NaOH-Modification of Montmorillonite K10 Clay
- the workup consisted of a vacuum filtration of the mixture using a medium porosity glass frit funnel.
- Figure 1 shows TMPD isobutyrate selectivity as a function of aldehyde conversion for isobutyraldehyde for several catalysts. As shown in Figure 1, the NaOH-modified K10 clay catalyst produced greater selectivity over a greater range of aldehyde conversion.
- the equipment for this reaction was a one liter round bottom flask equipped with a magnetic stirring bar, a thermowell with thermometer, an addition funnel, and a reflux condenser topped with a nitrogen inlet connected to a bubbler. Flame drying all equipment under a stream of dry nitrogen and maintaining a dry nitrogen blanket throughout the reaction ensured its minimum exposure to water and air.
- the assay of the isobutyraldehyde showed 15 ppm water and less than 100 ppm isobutyric acid.
- the reaction began by heating the aldehyde to reflux while stirring and adding a few drops of the sodium isobutoxide catalyst. An increased reflux rate indicating the onset of the reaction began after the addition of 1.5 milliliters of the catalyst solution. Adding the catalyst drop by drop thereafter was necessary to control the vigorous reflux.
- Figure 2 shows the main product yields for 2-methyl propanal as a function of conversion. Immediately below the conversion axis, the reflux temperatures corresponding to these conversions appear. As seen in Figure 2, at no conversion does the yield of the aldol / Tischenko product (2,2,4-trimethyl-3-hydroxy-l-pentyl 2-methylpropanoate) exceed 89 percent. And at some locations it falls below 25 percent. The factors limiting the yield of the aldol / Tischenko product are its transesterification into the diester and the glycol and the competing Cannizzarro reaction occurring before the aldehyde has undergone any aldol condensation.
- the Cannizzarro reaction is favored relative to the aldol condensation giving the Simple Ester rather than the Glycol Monoester product.
- the free aldehyde shuttles through the aldol route (provided there is at least one alpha hydrogen) giving the Glycol Monoester instead of the Simple Ester.
- Glycol 28.2 percent Glycol Diester, and 18.8 percent other materials.
- reaction temperature had climbed from 92 ° C to 157 ° C.
- Example 2 was repeated using 100 grams of 85 percent potassium hydroxide in place of the caustic solution. All other conditions were the same. Starting with 200 grams of the Montmorillonite K10, the yield of the dried, treated product was 174 grams (87 percent). Elemental analysis showed a potassium content of 12.5 weight percent.
- Example 9 Reaction of 2-Methylpropanal with KOH-Modified K10 Clay Catalyst
- Example 10 LiOH-Modification of Montmorillonite K10 Clay
- Example 2 was repeated using 100 grams of lithium hydroxide in place of the caustic solution. The water volume was also increased to 600 milliliters in this preparation. All other conditions were the same. Starting with 200 grams of the Montmorillonite K10 clay, the yield of the dried, treated product was 197 grams (98.5 percent). Elemental analysis showed a lithium content of 10.0 weight percent.
- Example 2 was repeated using 200 grams of Montmorillonite KSF in place of Montmorillonite K10. All other conditions were the same. Starting with 200 grams of the Montmorillonite KSF clay, the yield of the dried, treated product was 171.5 grams (85.8 percent). Elemental analysis showed a sodium content of 11.0 weight percent.
- Example 3 was repeated using 5.04 grams of the caustic modified Montmorillonite KSF clay from Example 12 as the catalyst. All other conditions were the same. After heating and stirring for 200 hours, the reaction temperature increased from 65 ° C to 130 ° C.
- the base-modified Montmorillonite K10 catalyst from Example 2 was air dried and formed into 4-6 mesh pellets. Heating these pellets to 300 ° C for 1 hour completed their preparation for bench unit operation.
- the reactor was a 1" x 24" stainless steel pipe containing a thermocouple to monitor the internal temperature and a pressure gauge to monitor the internal pressure.
- the catalyst pellets were loaded into this reactor and 4 separate reactions were run by pumping the substrate (2-methylpropanal) through the bed under a nitrogen pressure of 170 kPa.
- the process poremakers and results appear in Table II, below.
- Gly glycol
- Ale alcohol
- GM Glycol Monoester
- a 1 -Liter round bottom flask equipped with an overhead mechanical stirrer and a reflux condenser was charged with 201.3 grams of Montmorillonite KSF clay, 600 milliliters deionized water, and 152.7 grams of lithium hydroxide monohydrate (3.640 moles). This mixture was stirred and heated at reflux overnight. The slurry was then allowed to cool to room temperature. The solids were separated from the liquid by centrifugation. The liquid portion was decanted and discarded. The solids were washed by resuspending in 600 milliliters of deionized water and centrifuging. This sequence was repeated two more times to ensure removal of all soluble species. The catalyst was dried in an oven at 100 °C with flowing air for 24 hours. The yield of the final material was 214.2 grams.
- Example 15 was repeated using 205.5 g of Montmorillonite K10 clay in place of the KSF type clay. All other conditions were essentially the same.
- the yield of the dried material was 209.7 g.
- X-ray diffraction analysis of this material exhibited the characteristic pattern for montmorillonite with a dw, basal spacing of 10.2 A, identical to the untreated montmorillonite K10 clay.
- the lithium content of the material increased from 0.002 weight percent Li to 9.0 % by weight. This shows that different types of clay can be modified in the same manner.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000556865A JP2002519274A (en) | 1998-06-30 | 1999-06-30 | Basic clay catalyst for glycol monoester production |
EP99933613A EP1098699B1 (en) | 1998-06-30 | 1999-06-30 | Production of glycol monoester |
DE69907915T DE69907915T2 (en) | 1998-06-30 | 1999-06-30 | THE PRODUCTION OF GLYCOL MONOESTER |
BR9911753-3A BR9911753A (en) | 1998-06-30 | 1999-06-30 | Base-modified clay, process for preparing it, catalyst composition, and process for preparing a monoester glycol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9117398P | 1998-06-30 | 1998-06-30 | |
US60/091,173 | 1998-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000000282A1 true WO2000000282A1 (en) | 2000-01-06 |
Family
ID=22226435
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/014786 WO2000000282A1 (en) | 1998-06-30 | 1999-06-30 | Basic clay catalyst for the production of glycol monoester |
PCT/US1999/014785 WO2000000456A1 (en) | 1998-06-30 | 1999-06-30 | Preparation of an aldol using a base-modified clay catalyst |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/014785 WO2000000456A1 (en) | 1998-06-30 | 1999-06-30 | Preparation of an aldol using a base-modified clay catalyst |
Country Status (8)
Country | Link |
---|---|
US (3) | US6215020B1 (en) |
EP (1) | EP1098699B1 (en) |
JP (1) | JP2002519274A (en) |
CN (1) | CN1314826A (en) |
AU (1) | AU4847299A (en) |
BR (1) | BR9911753A (en) |
DE (1) | DE69907915T2 (en) |
WO (2) | WO2000000282A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69907915T2 (en) * | 1998-06-30 | 2004-01-15 | Eastman Chem Co | THE PRODUCTION OF GLYCOL MONOESTER |
WO2002079130A1 (en) * | 2001-03-30 | 2002-10-10 | Council Of Scientific And Industrial Research | A process for preparing alkylated dihydroxybenzene |
CN100537658C (en) * | 2005-01-18 | 2009-09-09 | 中国科学院化学研究所 | Polyester/clay composite material preparation method |
EP1877183A1 (en) | 2005-04-21 | 2008-01-16 | Shell Internationale Researchmaatschappij B.V. | Hydrogenation catalyst and hydrogenation method |
WO2007103858A2 (en) | 2006-03-06 | 2007-09-13 | Wisconsin Alumni Research Foundation | Stable, aqueous-phase, basic catalysts and reactions catalyzed thereby |
CN101454076A (en) | 2006-04-13 | 2009-06-10 | 国际壳牌研究有限公司 | Process for hydrogenating an aldehyde |
EP2380850B1 (en) * | 2009-01-08 | 2016-10-19 | Hailisheng Pharmaceutical Co., Ltd | Modified sodium-montmorillonite, preparing method and uses thereof |
WO2012174678A1 (en) * | 2011-06-23 | 2012-12-27 | 山东大展纳米材料有限公司 | Layered clay catalytic material and intercalation method thereof |
JP6270742B2 (en) * | 2013-01-10 | 2018-01-31 | 塩野義製薬株式会社 | Method for producing cross-linked nucleic acid derivative |
CN103230797B (en) * | 2013-05-16 | 2015-03-25 | 陕西师范大学 | Cobalt-loaded-on-alkali activated montmorillonoid catalyst and preparation method and application thereof |
DE102013021509B4 (en) | 2013-12-18 | 2020-10-01 | Oxea Gmbh | Process for the preparation of 3-hydroxyalkanals |
DE102013021512A1 (en) | 2013-12-18 | 2015-06-18 | Oxea Gmbh | Process for the preparation of 3-hydroxyalkanals |
CN104072367B (en) * | 2014-07-09 | 2016-07-06 | 德纳化工滨海有限公司 | A kind of continuous production method of 2,2,4-trimethyl-1,3-pentanediol mono isobutyrate |
DE102015000809A1 (en) | 2015-01-23 | 2016-07-28 | Oxea Gmbh | Process for the preparation of 3-hydroxyalkanals |
DE102015000810B4 (en) | 2015-01-23 | 2021-05-27 | Oq Chemicals Gmbh | Process for the preparation of 3-hydroxyalkanals |
CN114789059B (en) * | 2021-01-26 | 2024-01-09 | 荆楚理工学院 | Preparation method and application of catalyst for Michael addition reaction |
CN115746859A (en) * | 2022-09-09 | 2023-03-07 | 浙江慧丰环保科技有限公司 | Mercury-contaminated soil remediation curing agent, and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876706A (en) * | 1971-02-09 | 1975-04-08 | Oleg Evgenievich Levanevsky | Method of producing hydroxy aldehydes and keto-alcohols |
EP0284397A1 (en) * | 1987-03-26 | 1988-09-28 | The British Petroleum Company p.l.c. | Lithiated clays and uses thereof |
WO1992001509A1 (en) * | 1990-07-16 | 1992-02-06 | Michigan State University | COMPOSITE CLAY MATERIALS FOR REMOVAL OF SOx FROM GAS STREAMS |
EP0707887A2 (en) * | 1994-10-18 | 1996-04-24 | Chisso Corporation | A solid basic catalyst, a process for producing the same and a process for producing a carbonyl compound derivative using the same |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE391674C (en) | 1921-10-09 | 1924-03-10 | Consortium Elektrochem Ind | Process for the treatment of organic fluids with relatively small amounts of other fluids |
GB308285A (en) | 1927-10-21 | 1929-03-21 | Du Pont | Improvements in and relating to the production of ketonic alcohols |
FR870204A (en) | 1939-03-14 | 1942-03-05 | Degussa | Process for preparing unsaturated ketones having an extreme vinyl group |
US2879298A (en) | 1957-05-29 | 1959-03-24 | Philip Morris Inc | Production of diacetone alcohol |
US3081344A (en) | 1961-04-24 | 1963-03-12 | Eastman Kodak Co | Preparation of esters by aldehyde condensation |
US3091632A (en) | 1961-07-06 | 1963-05-28 | Eastman Kodak Co | Process for the production of glycol monoesters from aldehydes |
FR1296196A (en) | 1961-07-25 | 1962-06-15 | B A Shawinigan Ltd | Process for preparing mesityl oxide |
US3291821A (en) | 1963-11-04 | 1966-12-13 | Eastman Kodak Co | Preparation of glycol monoesters by condensation of aldehydes in the presence of an aqueous solution of a strong inorganic base |
GB1317106A (en) | 1971-03-18 | 1973-05-16 | Inst Orch Khim Akademii Nauk K | Method of procucing hydroxy aldehydes and keto-alcohols |
JPS5215582B2 (en) | 1971-10-04 | 1977-04-30 | ||
US3718689A (en) | 1972-02-10 | 1973-02-27 | Union Carbide Corp | Preparation of trisubstituted-hydroxyalkyl alkanoates |
CA1106409A (en) | 1977-10-07 | 1981-08-04 | Richard M. D'sidocky | Base modified catalysis in the styrenation of diphenylamine |
DE2820518A1 (en) | 1978-05-11 | 1979-11-15 | Basf Ag | PROCESS FOR THE PREPARATION OF 3-HYDROXY-2,2,4-TRIMETHYLPENTYLISOBUTYRATE |
JPS5865245A (en) | 1981-10-14 | 1983-04-18 | Kyowa Yuka Kk | Preparation of glycol monoester |
US4458026A (en) | 1982-06-02 | 1984-07-03 | Union Carbide Corporation | Catalysts for aldol condensations |
US4476324A (en) | 1982-06-02 | 1984-10-09 | Union Carbide Corporation | Catalyzed aldol condensations |
DE3447209A1 (en) | 1984-12-22 | 1986-07-03 | Haarmann & Reimer Gmbh, 3450 Holzminden | UNSYMMETRIC DIHYDRO-DITHIAZINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A SMELLING AND FLAVORING SUBSTANCE |
DE3447029A1 (en) | 1984-12-22 | 1986-06-26 | Ruhrchemie Ag, 4200 Oberhausen | METHOD FOR PRODUCING 2,2,4-TRIMETHYL-1,3-PENTANEDIOL MONOISOBUTYRATE |
US5026919A (en) | 1985-12-20 | 1991-06-25 | Mobil Oil Corporation | Base-catalyzed reactions using zeolite catalysts |
US4701562A (en) | 1986-06-25 | 1987-10-20 | Union Carbide Corporation | Process for the condensation of aldehydes |
US4704478A (en) | 1986-06-25 | 1987-11-03 | Union Carbide Corporation | Process for the condensation of ketones |
US5180847A (en) | 1991-02-15 | 1993-01-19 | Basf Corporation | Processes for preparing 2,2,4-trimethyl-1,3-pentanediol derivatives |
US5144089A (en) | 1991-10-21 | 1992-09-01 | Uop | 2-ethyl-2-hexenal by aldol condensation of butyraldehyde in a continuous process |
US5157161A (en) | 1991-12-09 | 1992-10-20 | Texaco Chemical Company | One-step synthesis of methyl t-butyl ether from t-butanol using hydrogen fluoride-modified montmorillonite clays |
FR2688223B1 (en) * | 1992-03-05 | 1994-05-20 | Institut Francais Petrole | NEW PROCESS FOR SOFTENING OIL CUTS WITHOUT REGULAR ADDITION OF AQUEOUS ALKALINE SOLUTION, USING A BASIC SOLID CATALYST. |
US5254743A (en) | 1992-12-09 | 1993-10-19 | Uop | Solid bases as catalysts in aldol condensations |
US5409597A (en) * | 1993-10-12 | 1995-04-25 | Uop | Hydrocarbon conversion process using a pillared clay containing fluorided pillars |
AUPN012194A0 (en) * | 1994-12-16 | 1995-01-19 | University Of Queensland, The | Alumino-silicate derivatives |
FR2753717B1 (en) * | 1996-09-24 | 1998-10-30 | PROCESS AND PLANT FOR THE PRODUCTION OF LOW SULFUR CATALYTIC CRACKING ESSENCES | |
DE69907915T2 (en) * | 1998-06-30 | 2004-01-15 | Eastman Chem Co | THE PRODUCTION OF GLYCOL MONOESTER |
-
1999
- 1999-06-30 DE DE69907915T patent/DE69907915T2/en not_active Expired - Fee Related
- 1999-06-30 CN CN99810056A patent/CN1314826A/en active Pending
- 1999-06-30 US US09/343,215 patent/US6215020B1/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/US1999/014786 patent/WO2000000282A1/en active IP Right Grant
- 1999-06-30 EP EP99933613A patent/EP1098699B1/en not_active Expired - Lifetime
- 1999-06-30 JP JP2000556865A patent/JP2002519274A/en active Pending
- 1999-06-30 BR BR9911753-3A patent/BR9911753A/en not_active IP Right Cessation
- 1999-06-30 WO PCT/US1999/014785 patent/WO2000000456A1/en active Application Filing
- 1999-06-30 AU AU48472/99A patent/AU4847299A/en not_active Abandoned
-
2000
- 2000-11-28 US US09/722,294 patent/US6794325B1/en not_active Expired - Fee Related
-
2004
- 2004-09-20 US US10/944,404 patent/US20050113242A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876706A (en) * | 1971-02-09 | 1975-04-08 | Oleg Evgenievich Levanevsky | Method of producing hydroxy aldehydes and keto-alcohols |
EP0284397A1 (en) * | 1987-03-26 | 1988-09-28 | The British Petroleum Company p.l.c. | Lithiated clays and uses thereof |
WO1992001509A1 (en) * | 1990-07-16 | 1992-02-06 | Michigan State University | COMPOSITE CLAY MATERIALS FOR REMOVAL OF SOx FROM GAS STREAMS |
EP0707887A2 (en) * | 1994-10-18 | 1996-04-24 | Chisso Corporation | A solid basic catalyst, a process for producing the same and a process for producing a carbonyl compound derivative using the same |
Also Published As
Publication number | Publication date |
---|---|
US6794325B1 (en) | 2004-09-21 |
BR9911753A (en) | 2001-04-03 |
EP1098699A1 (en) | 2001-05-16 |
EP1098699B1 (en) | 2003-05-14 |
CN1314826A (en) | 2001-09-26 |
US20050113242A1 (en) | 2005-05-26 |
WO2000000456A1 (en) | 2000-01-06 |
AU4847299A (en) | 2000-01-17 |
US6215020B1 (en) | 2001-04-10 |
DE69907915D1 (en) | 2003-06-18 |
JP2002519274A (en) | 2002-07-02 |
DE69907915T2 (en) | 2004-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1098699B1 (en) | Production of glycol monoester | |
KR101442857B1 (en) | Process for codimerizing olefins | |
CN1021636C (en) | Improved aldehyde hydrogenation catalyst and process | |
CN102665900B (en) | Hydrogenation catalyst, process for production thereof, and use thereof | |
US4751248A (en) | Preparation of alcohols from synthesis gas | |
JPS6322043A (en) | Manufacture of glycol ethers | |
JPH0656730A (en) | Method of aldol condensation of solid basic catalyst comprising magnesium oxide and aluminum oxide having large surface area | |
EP2893976B1 (en) | Copper-based catalyst precursor, method for manufacturing same, and hydrogenation method | |
CN103476492B (en) | For aldehyde being hydrogenated the promoted cu zn catalyst for alcohol | |
Dill et al. | Brazilian mineral clays: classification, acid activation and application as catalysts for methyl esterification reactions | |
JPS6125A (en) | Manufacture of diene | |
JP2010511006A (en) | Method for producing 3-alkoxypropan-1-ol | |
JPS59105847A (en) | Method of synthesizing multicomponent acidic catalyst by organic solution method | |
MXPA00012544A (en) | Basic clay catalyst for the production of glycol monoester | |
JPH06107601A (en) | Production of dialkyl carbonate | |
JP2023515147A (en) | Chromium-free hydrogenation catalyst with excellent water and acid stability | |
TW531529B (en) | Synthesis of glycol ethers | |
CN104968639B (en) | By the manufacturing method of 1,2- alkanediol synthesis saturated aldehyde | |
JP3726123B2 (en) | Production method of dialkyl carbonate | |
JP2805296B2 (en) | Method for producing 4-oxa-amines | |
JPH0847639A (en) | Catalyst and catalyst-containing(carrier)-molded article | |
Mhadhbi et al. | DESIGN OF HETEROGENOUS CATALYSIS IN ORGANIC SYNTHESIS | |
JPH0820561A (en) | Production of carbonic acid ester | |
JP3987250B2 (en) | Ether production method | |
EP0645359B1 (en) | Synthesis of alkyl t-alkyl ether using pillared, phosphated montmorillonite clay catalysts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 99810056.0 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): BR CN JP MX SG |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2000/012544 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1999933613 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1999933613 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1999933613 Country of ref document: EP |