WO2000000620A3 - Dna encoding methymycin and pikromycin - Google Patents

Dna encoding methymycin and pikromycin Download PDF

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Publication number
WO2000000620A3
WO2000000620A3 PCT/US1999/014398 US9914398W WO0000620A3 WO 2000000620 A3 WO2000000620 A3 WO 2000000620A3 US 9914398 W US9914398 W US 9914398W WO 0000620 A3 WO0000620 A3 WO 0000620A3
Authority
WO
WIPO (PCT)
Prior art keywords
pikromycin
methymycin
dna encoding
gene cluster
biosynthetic gene
Prior art date
Application number
PCT/US1999/014398
Other languages
French (fr)
Other versions
WO2000000620A2 (en
Inventor
David H Sherman
Hung-Wen Liu
Yongquan Xue
Lishan Zhao
Original Assignee
Univ Minnesota
David H Sherman
Liu Hung Wen
Yongquan Xue
Lishan Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota, David H Sherman, Liu Hung Wen, Yongquan Xue, Lishan Zhao filed Critical Univ Minnesota
Priority to CA002332129A priority Critical patent/CA2332129A1/en
Priority to AU47199/99A priority patent/AU4719999A/en
Priority to JP2000557373A priority patent/JP2002536959A/en
Priority to EP99930718A priority patent/EP1090125A2/en
Publication of WO2000000620A2 publication Critical patent/WO2000000620A2/en
Publication of WO2000000620A3 publication Critical patent/WO2000000620A3/en
Priority to US09/988,384 priority patent/US20030073824A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Abstract

A biosynthetic gene cluster for methymycin and pikromycin as well as a biosynthetic gene cluster for desosamine is provided.
PCT/US1999/014398 1998-06-26 1999-06-25 Dna encoding methymycin and pikromycin WO2000000620A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002332129A CA2332129A1 (en) 1998-06-26 1999-06-25 Dna encoding methymycin and pikromycin
AU47199/99A AU4719999A (en) 1998-06-26 1999-06-25 Dna encoding methymycin and pikromycin
JP2000557373A JP2002536959A (en) 1998-06-26 1999-06-25 Genes encoding methymycin and picromycin
EP99930718A EP1090125A2 (en) 1998-06-26 1999-06-25 Dna encoding methymycin and pikromycin
US09/988,384 US20030073824A1 (en) 1999-06-25 2001-11-19 DNA encoding methymycin and pikromycin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/105,537 1998-06-26
US09/105,537 US6265202B1 (en) 1998-06-26 1998-06-26 DNA encoding methymycin and pikromycin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/988,384 Continuation US20030073824A1 (en) 1999-06-25 2001-11-19 DNA encoding methymycin and pikromycin

Publications (2)

Publication Number Publication Date
WO2000000620A2 WO2000000620A2 (en) 2000-01-06
WO2000000620A3 true WO2000000620A3 (en) 2000-04-13

Family

ID=22306384

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/014398 WO2000000620A2 (en) 1998-06-26 1999-06-25 Dna encoding methymycin and pikromycin

Country Status (6)

Country Link
US (4) US6265202B1 (en)
EP (1) EP1090125A2 (en)
JP (1) JP2002536959A (en)
AU (1) AU4719999A (en)
CA (1) CA2332129A1 (en)
WO (1) WO2000000620A2 (en)

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AU2001296652A1 (en) * 2000-10-05 2002-04-15 Regents Of The University Of Minnesota Method to alter sugar moieties
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US20040161839A1 (en) * 2001-10-05 2004-08-19 Hung-Wen Liu Method to alter sugar moieties
WO2004024744A2 (en) * 2002-07-31 2004-03-25 The Board Of Trustees Of The Leland Stanford Junior University Production of glycosylated macrolides in e. coli
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US7288396B2 (en) * 2003-09-11 2007-10-30 Kosan Biosciences Incorporated Biosynthetic gene cluster for leptomycins
KR100636653B1 (en) 2004-04-27 2006-10-19 주식회사 진켐 Novel Olivosyl Pikromycin Derivatives and Method for Preparing the Same
KR100649394B1 (en) 2004-04-27 2006-11-24 주식회사 진켐 Novel Olivosyl Methymycin Derivatives and Method for Preparing the Same
WO2010034243A1 (en) 2008-09-24 2010-04-01 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
US8292863B2 (en) 2009-10-21 2012-10-23 Donoho Christopher D Disposable diaper with pouches
MX2013008062A (en) 2011-01-28 2013-08-09 Amyris Inc Gel-encapsulated microcolony screening.
KR20140032438A (en) 2011-05-13 2014-03-14 아미리스 인코퍼레이티드 Methods and compositions for detecting microbial production of water-immiscible compounds
AU2013299608B2 (en) 2012-08-07 2019-02-21 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
MX364748B (en) 2013-03-15 2019-05-06 Amyris Inc Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds.
US10563229B2 (en) 2013-08-07 2020-02-18 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
BR112017027970A2 (en) 2015-06-25 2018-08-28 Amyris, Inc. maltose-dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in the production of non-catabolic compounds
CN106916834B (en) * 2015-12-24 2022-08-05 武汉合生科技有限公司 Biosynthetic gene cluster of compounds and application thereof

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Also Published As

Publication number Publication date
EP1090125A2 (en) 2001-04-11
JP2002536959A (en) 2002-11-05
AU4719999A (en) 2000-01-17
US20020164742A1 (en) 2002-11-07
US6265202B1 (en) 2001-07-24
US20030087405A1 (en) 2003-05-08
WO2000000620A2 (en) 2000-01-06
US20020110897A1 (en) 2002-08-15
CA2332129A1 (en) 2000-01-06

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