WO2000001850A2 - Molecular torches - Google Patents
Molecular torches Download PDFInfo
- Publication number
- WO2000001850A2 WO2000001850A2 PCT/US1999/015098 US9915098W WO0001850A2 WO 2000001850 A2 WO2000001850 A2 WO 2000001850A2 US 9915098 W US9915098 W US 9915098W WO 0001850 A2 WO0001850 A2 WO 0001850A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- target
- torch
- domain
- closing
- target binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
Definitions
- T m melting temperature
- the molecular torch is well suited for use in a transcription-associated amplification because the T m of the target binding domaimtarget closing domain hybrid can readily be adjusted to be higher than the temperature used during the amplification.
- the closed target binding domain prevents the molecular torch from prematurely binding to target sequences generated by amplification.
- Reagent 2 12.5 mM MgCl 2 , 17.5 mM KCl, 0.15 mM zinc acetate, 5% glycerol, 6.25 mM ATP, 2.5 mM CTP, 6.25 mM GTP, 2.5 mM UTP, 0.2 mM dATP, 0.2 mM dCTP, 0.2 mM dGTP, 0.2 mM dTTP, 50 mM Trizma base, 53 mM trehalose, 100 ⁇ M desferoxamine, and 2 mM spermidine, at pH 8.0;
- Condition A was made up of 25 ⁇ l of Reagent 2, 20 ⁇ l of Reagent 4, 50 ⁇ l of sample, reverse transcriptase (-33.4 ⁇ g), T7 RNA polymerase (-540 ng) and primers.
- Condition B was made up of 20 ⁇ l Reagent 3, 25 ⁇ l of Reagent 2, 50 ⁇ l of sample, and primers.
- Condition C was the same as condition A, but without the presence of primers.
- Condition D was the same as condition B, but without the presence of primers.
- Torch 8 (see Figure 7) was designed and tested for its ability to detect an RNA target sequence in solution.
- Torch 8 was made up of the nucleotide base recognition of SEQ ED NO: 9 (5'-cggcugcagg ggaaagaaua gttttttccc ctgcagccg-3'), where the 5'-ugcaggggaaagaauag-3' portion represents the target binding domain, the 5'-tcccctgcagccg-3' portion represents the target closing domain, the 5'-cggc-3' portion represents a "clamp" region for binding a portion of the target closing domain sequence, and the 5'-ttttt-3' portion was a deoxyribonucleotide joining region.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2333253A CA2333253C (en) | 1998-07-02 | 1999-07-01 | Molecular torches |
AU48575/99A AU762728B2 (en) | 1998-07-02 | 1999-07-01 | Molecular torches |
AT99932220T ATE440963T1 (en) | 1998-07-02 | 1999-07-01 | MOLECULAR TORCHES |
EP99932220A EP1092047B1 (en) | 1998-07-02 | 1999-07-01 | Molecular torches |
JP2000558240A JP4646404B2 (en) | 1998-07-02 | 1999-07-01 | Molecular torch |
DE69941333T DE69941333D1 (en) | 1998-07-02 | 1999-07-01 | MOLECULAR TORCHES |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9161698P | 1998-07-02 | 1998-07-02 | |
US60/091,616 | 1998-07-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000001850A2 true WO2000001850A2 (en) | 2000-01-13 |
WO2000001850A3 WO2000001850A3 (en) | 2000-04-06 |
Family
ID=22228747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/015098 WO2000001850A2 (en) | 1998-07-02 | 1999-07-01 | Molecular torches |
Country Status (9)
Country | Link |
---|---|
US (6) | US6361945B1 (en) |
EP (1) | EP1092047B1 (en) |
JP (2) | JP4646404B2 (en) |
AT (1) | ATE440963T1 (en) |
AU (1) | AU762728B2 (en) |
CA (1) | CA2333253C (en) |
DE (1) | DE69941333D1 (en) |
ES (1) | ES2330812T3 (en) |
WO (1) | WO2000001850A2 (en) |
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US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
US7718354B2 (en) | 2001-03-02 | 2010-05-18 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
US20040121311A1 (en) * | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in livestock |
US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
US7297494B2 (en) * | 2001-06-25 | 2007-11-20 | Georgia Tech Research Corporation | Activatable probes and methods for in vivo gene detection |
US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
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US7214780B2 (en) * | 2001-11-02 | 2007-05-08 | Gen-Probe Incorporated | Probes, compositions and kits for determining the presence of Mycoplasma pneuomoniae in a test sample |
US20070059690A1 (en) * | 2002-05-31 | 2007-03-15 | Amirul Islam | "Met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands" |
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US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
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US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
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US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
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US20120122103A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
WO2005029705A2 (en) | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
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WO2005042763A2 (en) | 2003-10-28 | 2005-05-12 | Bioarray Solutions Ltd. | Optimization of gene expression analysis using immobilized capture probes |
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US8163895B2 (en) | 2003-12-05 | 2012-04-24 | Ibis Biosciences, Inc. | Compositions for use in identification of orthopoxviruses |
ES2383947T3 (en) | 2003-12-19 | 2012-06-27 | Gen-Probe Incorporated | Compositions, methods and equipment for the detection of nucleic acids from hiv-1 and hiv-2 |
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US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
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US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
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US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
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JP2008531052A (en) * | 2005-02-28 | 2008-08-14 | ジェン−プローブ・インコーポレーテッド | Composition and method for detecting an analyte using a nucleic acid hybridization switch probe |
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US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
US7727721B2 (en) * | 2005-03-08 | 2010-06-01 | California Institute Of Technology | Hybridization chain reaction amplification for in situ imaging |
EP2333561A3 (en) | 2005-03-10 | 2014-06-11 | Gen-Probe Incorporated | System for performing multi-formatted assays |
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US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
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AU2006272776B2 (en) | 2005-07-21 | 2012-01-19 | Ibis Biosciences, Inc. | Methods for rapid identification and quantitation of nucleic acid variants |
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EP1931806B1 (en) | 2005-10-07 | 2011-10-05 | California Institute Of Technology | Pkr activation via hybridization chain reaction |
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DE202005017542U1 (en) * | 2005-11-08 | 2006-01-12 | Pfankuch Maschinen Gmbh | Device for applying a hanging label to a bottle neck |
US20070243534A1 (en) * | 2006-04-12 | 2007-10-18 | Michael Seul | Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase |
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US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
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EP2069536B1 (en) | 2006-08-01 | 2014-11-05 | Gen-Probe Incorporated | Methods of nonspecific target capture of nucleic acids |
JP5420412B2 (en) | 2006-09-14 | 2014-02-19 | アイビス バイオサイエンシズ インコーポレイティッド | Targeted whole genome amplification method for pathogen identification |
US8008034B2 (en) * | 2006-10-13 | 2011-08-30 | Theranos, Inc. | Reducing optical interference in a fluidic device |
US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
EP3095873B1 (en) * | 2006-12-21 | 2018-04-18 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
WO2008104002A2 (en) | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
US8183359B2 (en) * | 2007-03-01 | 2012-05-22 | Gen-Probe Incorporated | Kits for amplifying DNA |
WO2008106658A2 (en) | 2007-03-01 | 2008-09-04 | California Institute Of Technology | TRIGGERED RNAi |
EP1978111B1 (en) | 2007-04-02 | 2013-03-27 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa |
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US20110020947A1 (en) * | 2007-04-25 | 2011-01-27 | 3M Innovative Properties Company | Chemical component and processing device assembly |
WO2008144562A1 (en) | 2007-05-16 | 2008-11-27 | California Institute Of Technology | A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
WO2008151023A2 (en) * | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
US9458451B2 (en) | 2007-06-21 | 2016-10-04 | Gen-Probe Incorporated | Multi-channel optical measurement instrument |
ES2376509T3 (en) | 2007-07-06 | 2012-03-14 | The Regents Of The University Of Michigan | REPORTS OF GENES MIPOL 1-ETV1. |
EP2604701B1 (en) | 2007-07-06 | 2015-11-04 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
WO2009012387A2 (en) * | 2007-07-18 | 2009-01-22 | Gen-Probe Incorporated | Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer |
EP2215211A1 (en) * | 2007-11-06 | 2010-08-11 | 3M Innovative Properties Company | Processing device tablet |
CA2715991A1 (en) * | 2007-12-26 | 2009-07-09 | Gen-Probe Incorporated | Amplification oligomers and methods to detect candida albicans 26s rrna or encoding dna |
US8497364B2 (en) * | 2008-02-27 | 2013-07-30 | California Institute Of Technology | Triggered RNAi |
US20090304714A1 (en) * | 2008-03-25 | 2009-12-10 | The Regents Of The University Of Michigan | IKKi Inhibitor Therapies and Screening Methods, and Related IKKi Diagnostics |
CA2721536A1 (en) | 2008-04-21 | 2009-10-29 | Gen-Probe Incorporated | Method for detecting chikungunya virus |
US20100021904A1 (en) * | 2008-05-21 | 2010-01-28 | Pierce Niles A | Shielded cross-linking probes |
US8241854B2 (en) * | 2008-05-22 | 2012-08-14 | California Institute Of Technology | Triggered RNAi |
US20100021901A1 (en) * | 2008-05-22 | 2010-01-28 | Peng Yin | Compositions and methods for detecting analytes |
EP2291553A4 (en) | 2008-05-28 | 2011-12-14 | Genomedx Biosciences Inc | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
WO2009158119A2 (en) * | 2008-05-30 | 2009-12-30 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of salmonella |
CN102112632A (en) * | 2008-08-08 | 2011-06-29 | 史密斯探测公司 | Detection algorithm for PCR assay |
EP2331703A2 (en) * | 2008-09-12 | 2011-06-15 | Promega Corporation | Assessing expression of endogenous and exogenous genes |
WO2010033627A2 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
US8550694B2 (en) | 2008-09-16 | 2013-10-08 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
WO2010033625A1 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Microplate handling systems and related computer program products and methods |
EP2389449B1 (en) | 2008-12-30 | 2015-02-18 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of listeria |
WO2010081001A2 (en) | 2009-01-09 | 2010-07-15 | The Regents Of The University Of Michigan | Recurrent gene fusions in cancer |
US8368882B2 (en) | 2009-01-30 | 2013-02-05 | Gen-Probe Incorporated | Systems and methods for detecting a signal and applying thermal energy to a signal transmission element |
WO2010093943A1 (en) | 2009-02-12 | 2010-08-19 | Ibis Biosciences, Inc. | Ionization probe assemblies |
US8921039B2 (en) | 2009-02-26 | 2014-12-30 | Gen-Probe Incorporated | Assay for detection of human parvovirus nucleic acid |
WO2010114842A1 (en) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
WO2010126913A1 (en) | 2009-04-27 | 2010-11-04 | Gen-Probe Incorporated | Methods and kits for use in the selective amplification of target sequences |
EP2446057B1 (en) | 2009-06-23 | 2014-11-19 | Gen-Probe Incorporated | Compositions and methods for detecting nucleic acid from mollicutes |
WO2011003020A1 (en) | 2009-07-01 | 2011-01-06 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
US8950604B2 (en) | 2009-07-17 | 2015-02-10 | Ibis Biosciences, Inc. | Lift and mount apparatus |
EP2454000A4 (en) | 2009-07-17 | 2016-08-10 | Ibis Biosciences Inc | Systems for bioagent identification |
WO2011011535A2 (en) | 2009-07-21 | 2011-01-27 | Gen-Probe Incorporated | Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range |
US8409802B2 (en) * | 2009-08-14 | 2013-04-02 | Roche Molecular Systems, Inc. | Format of probes to detect nucleic acid differences |
GB0915664D0 (en) | 2009-09-08 | 2009-10-07 | Enigma Diagnostics Ltd | Reaction method |
CN102712953A (en) | 2009-09-17 | 2012-10-03 | 密歇根大学董事会 | Recurrent gene fusions in prostate cancer |
WO2011047307A1 (en) | 2009-10-15 | 2011-04-21 | Ibis Biosciences, Inc. | Multiple displacement amplification |
US8790879B2 (en) * | 2010-01-22 | 2014-07-29 | Gen-Probe Incorporated | Probes for detecting the presence of Trichomonas vaginalis in a sample |
WO2011103274A1 (en) | 2010-02-17 | 2011-08-25 | Gen-Probe Incorporated | Compositions and methods to detect atopobium vaginae nucleic acid |
US8383793B2 (en) | 2010-04-15 | 2013-02-26 | St. Jude Children's Research Hospital | Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors |
WO2011133811A2 (en) | 2010-04-21 | 2011-10-27 | Gen-Probe Incorporated | Compositions, methods and kits to detect herpes simplex virus nucleic acid |
US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
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EP2591363B1 (en) | 2010-07-07 | 2017-09-20 | The Regents Of The University Of Michigan | Diagnosis and treatment of breast cancer |
EP3301195B1 (en) | 2010-07-12 | 2022-11-02 | Gen-Probe Incorporated | Compositions and assays to detect 2009 swine h1n1 influenza a virus nucleic acid |
US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
WO2012030856A2 (en) | 2010-08-30 | 2012-03-08 | Gen-Probe Incorporated | Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus |
EP2616555B1 (en) | 2010-09-16 | 2017-11-08 | Gen-Probe Incorporated | Capture probes immobilizable via l-nucleotide tail |
EP2625297B1 (en) | 2010-10-04 | 2018-10-10 | Gen-Probe Prodesse, Inc. | Compositions, methods and kits to detect adenovirus nucleic acids |
US10093981B2 (en) | 2010-10-19 | 2018-10-09 | Northwestern University | Compositions and methods for identifying depressive disorders |
US10233501B2 (en) | 2010-10-19 | 2019-03-19 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
US20150225792A1 (en) | 2014-01-17 | 2015-08-13 | Northwestern University | Compositions and methods for identifying depressive disorders |
US20150218639A1 (en) | 2014-01-17 | 2015-08-06 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
US8945556B2 (en) | 2010-11-19 | 2015-02-03 | The Regents Of The University Of Michigan | RAF gene fusions |
AU2011329753B2 (en) | 2010-11-19 | 2015-07-23 | The Regents Of The University Of Michigan | ncRNA and uses thereof |
WO2012112558A1 (en) | 2011-02-14 | 2012-08-23 | The Regents Of The University Of Michigan | Compositions and methods for the treatment of obesity and related disorders |
CN103403533B (en) | 2011-02-24 | 2017-02-15 | 简.探针公司 | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
EP2683833B1 (en) | 2011-03-10 | 2018-09-26 | Gen-Probe Incorporated | Methods for the selection and optimization of oligonucleotide tag sequences |
AU2012249751B2 (en) | 2011-04-25 | 2016-11-03 | Gen-Probe Incorporated | Compositions and methods for detecting BV-associated bacterial nucleic acid |
AU2012284307A1 (en) | 2011-07-15 | 2013-05-09 | Gen-Probe Incorporated | Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis A virus nucleic acids in single-plex or multiplex assays |
US9663829B2 (en) | 2011-09-08 | 2017-05-30 | Gen-Probe Incorporated | Compositions and methods for detecting BV-associated bacterial nucleic acid |
EP2758547B1 (en) | 2011-09-21 | 2015-09-16 | Gen-Probe Incorporated | Methods for amplifying nucleic acid using tag-mediated displacement |
EP2773772A1 (en) | 2011-11-04 | 2014-09-10 | Oslo Universitetssykehus HF | Methods and biomarkers for analysis of colorectal cancer |
EP3492604B1 (en) | 2011-11-04 | 2021-01-06 | Gen-Probe Incorporated | Molecular assay reagents and methods |
DE102011120550B4 (en) | 2011-12-05 | 2013-11-07 | Gen-Probe Prodesse, Inc. | Compositions, methods and kits for the detection of adenovirus nucleic acids |
WO2013096460A1 (en) | 2011-12-20 | 2013-06-27 | The Regents Of The University Of Michigan | Pseudogenes and uses thereof |
WO2013096838A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
WO2013096799A1 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
US9970061B2 (en) | 2011-12-27 | 2018-05-15 | Ibis Biosciences, Inc. | Bioagent detection oligonucleotides |
CA2860594A1 (en) | 2012-01-09 | 2013-07-18 | Oslo Universitetssykehus Hf | Methods and biomarkers for analysis of colorectal cancer |
CN107326085B (en) | 2012-02-03 | 2022-05-03 | 加州理工学院 | Encoding and decoding of signals in multiplexed biochemical assays |
US9506117B2 (en) | 2012-02-21 | 2016-11-29 | Oslo Universitetssykehus Hf | Methods and biomarkers for detection and prognosis of cervical cancer |
AU2013205010B2 (en) | 2012-02-24 | 2016-10-20 | Gen-Probe Incorporated | Detection of Shiga toxin genes in bacteria |
CA2866254A1 (en) | 2012-03-06 | 2013-09-12 | Oslo Universitetssykehus Hf | Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer |
WO2013152114A1 (en) | 2012-04-03 | 2013-10-10 | The Regents Of The University Of Michigan | Biomarker associated with irritable bowel syndrome and crohn's disease |
AU2013205110B2 (en) | 2012-04-24 | 2016-10-13 | Gen-Probe Incorporated | Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids |
AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
AU2013202804A1 (en) | 2012-06-14 | 2014-01-16 | Gen-Probe Incorporated | Use of a fluorescent material to detect failure or deteriorated performance of a fluorometer |
WO2014005076A2 (en) | 2012-06-29 | 2014-01-03 | The Regents Of The University Of Michigan | Methods and biomarkers for detection of kidney disorders |
EP2885640B1 (en) | 2012-08-16 | 2018-07-18 | Genomedx Biosciences, Inc. | Prostate cancer prognostics using biomarkers |
ES2761920T3 (en) | 2012-08-30 | 2020-05-21 | Gen Probe Inc | Multiphasic nucleic acid amplification |
AU2013205122B2 (en) | 2012-10-11 | 2016-11-10 | Gen-Probe Incorporated | Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid |
WO2014072832A2 (en) | 2012-10-18 | 2014-05-15 | Oslo Universitetstssykehus Hf | Biomarkers for cervical cancer |
AU2013205090B2 (en) | 2012-12-07 | 2016-07-28 | Gen-Probe Incorporated | Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid |
WO2014160233A1 (en) | 2013-03-13 | 2014-10-02 | Abbott Molecular Inc. | Systems and methods for isolating nucleic acids |
AU2013202788B2 (en) | 2013-03-14 | 2015-10-01 | Gen-Probe Incorporated | Indexing signal detection module |
CN105378107A (en) | 2013-03-14 | 2016-03-02 | 雅培分子公司 | Multiplex methylation-specific amplification systems and methods |
CN105392892A (en) | 2013-03-27 | 2016-03-09 | 六品科技公司 | Recombinant phage and bacterial detection methods |
ES2727898T3 (en) | 2013-05-02 | 2019-10-21 | Univ Michigan Regents | Deuterated Amlexanox with enhanced metabolic stability |
JP2016521996A (en) | 2013-06-19 | 2016-07-28 | サンプルシックス テクノロジーズ,インコーポレイティド | Phage-based bacterial detection assay |
US9856472B2 (en) | 2013-07-01 | 2018-01-02 | California Institute Of Technology | Small conditional RNAs |
EP3033437B1 (en) | 2013-08-14 | 2023-11-08 | Gen-Probe Incorporated | Compositions and methods for detecting hev nucleic acid |
WO2015089438A1 (en) | 2013-12-13 | 2015-06-18 | Northwestern University | Biomarkers for post-traumatic stress states |
EP3670663A1 (en) | 2014-02-28 | 2020-06-24 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
GB2528344B (en) | 2014-02-28 | 2018-10-31 | Gen Probe Inc | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
US10760109B2 (en) | 2014-06-06 | 2020-09-01 | The Regents Of The University Of Michigan | Compositions and methods for characterizing and diagnosing periodontal disease |
GB2536745B (en) | 2014-10-20 | 2019-06-26 | Gen Probe Inc | Red Blood cell lysis solution |
JP6944873B2 (en) | 2015-01-09 | 2021-10-06 | ジェン−プローブ・インコーポレーテッド | Methods and Compositions for Diagnosing Bacterial Vaginal Disease |
US10550438B2 (en) | 2015-03-16 | 2020-02-04 | Gen-Probe Incorporated | Methods and compositions for detecting bacterial nucleic acid |
WO2016196478A1 (en) | 2015-06-01 | 2016-12-08 | St. Jude Children's Research Hospital | Methods and compositions for prognostications and/or clinical management of graft-versus-host disease and transplant rejection |
EP3764079B1 (en) | 2015-12-31 | 2023-08-09 | Gen-Probe Incorporated | System and method for monitoring the performance of an optical signal detector |
EP4249609A3 (en) | 2016-01-04 | 2023-12-20 | Gen-Probe Incorporated | Methods and compositions for detecting candida species |
EP3407974A4 (en) | 2016-01-29 | 2019-08-28 | The Regents Of The University Of Michigan | Amlexanox analogs |
CA3021914A1 (en) | 2016-04-27 | 2017-11-02 | Gen-Probe Incorporated | Blood cell lysis reagent |
EP3985131A1 (en) | 2016-06-10 | 2022-04-20 | Gen-Probe Incorporated | Compositions and methods for detecting zika virus nucleic acid |
EP3943613A1 (en) | 2016-07-05 | 2022-01-26 | California Institute of Technology | Fractional initiator hybridization chain reaction |
US11091795B2 (en) | 2016-07-11 | 2021-08-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for diagnosing and treating arrhythmias |
CN110506127B (en) | 2016-08-24 | 2024-01-12 | 维拉科特Sd公司 | Use of genomic tags to predict responsiveness of prostate cancer patients to post-operative radiation therapy |
WO2018044939A1 (en) | 2016-08-30 | 2018-03-08 | California Institute Of Technology | Immunohistochemistry via hybridization chain reaction |
AU2017346854A1 (en) | 2016-10-19 | 2019-05-30 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying hepatitis C virus |
US10508313B2 (en) | 2016-11-21 | 2019-12-17 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying Hepatitis B virus |
WO2018127786A1 (en) | 2017-01-06 | 2018-07-12 | Oslo Universitetssykehus Hf | Compositions and methods for determining a treatment course of action |
US11208697B2 (en) | 2017-01-20 | 2021-12-28 | Decipher Biosciences, Inc. | Molecular subtyping, prognosis, and treatment of bladder cancer |
WO2018165600A1 (en) | 2017-03-09 | 2018-09-13 | Genomedx Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
EP3601617B3 (en) | 2017-03-24 | 2024-03-20 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying parainfluenza virus |
EP4212635A1 (en) | 2017-03-24 | 2023-07-19 | Gen-Probe Incorporated | Compositions and methods for detection of rsv a in samples |
EP4219768A3 (en) | 2017-03-25 | 2023-10-11 | Gen-Probe Incorporated | Compositions, methods and kits to detect metapneumovirus nucleic acids |
AU2018265274B2 (en) | 2017-05-11 | 2021-10-07 | Gen-Probe Incorporated | Compositions and methods for isolating target nucleic acids |
CA3062716A1 (en) | 2017-05-12 | 2018-11-15 | Decipher Biosciences, Inc. | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
WO2018226798A1 (en) | 2017-06-07 | 2018-12-13 | Gen-Probe Incorporated | Detecting babesia species nucleic acid in a sample |
CA3155871A1 (en) | 2017-07-10 | 2019-01-17 | Gen-Probe Incorporated | Analytical systems and methods for nucleic acid amplification using sample assigning parameters |
CA3072452A1 (en) | 2017-08-11 | 2019-02-14 | Gen-Probe Incorporated | Compositions and methods for detecting staphylococcus aureus |
US11377688B2 (en) | 2017-11-17 | 2022-07-05 | Gen-Probe Incorporated | Compositions and methods for detecting C1orf43 nucleic acid |
WO2019118550A1 (en) | 2017-12-13 | 2019-06-20 | Gen-Probe Incorporated | Methods for biological sample processing |
JP2021506274A (en) | 2017-12-15 | 2021-02-22 | ジェン−プローブ・インコーポレーテッド | Compositions and methods for detecting toxin-producing Clostridium difficile |
AU2019212931A1 (en) | 2018-01-29 | 2020-08-27 | Gen-Probe Incorporated | Analytical systems and methods |
WO2019202536A1 (en) | 2018-04-18 | 2019-10-24 | St. Jude Children's Research Hospital | Genotyping assays to identify mutations in xaf1 |
CH716454B1 (en) | 2018-06-13 | 2023-05-15 | Gen Probe Inc | Compositions and methods for detecting Group B Streptococcus nucleic acid. |
CA3105684A1 (en) | 2018-07-10 | 2020-01-16 | Gen-Probe Incorporated | Methods and systems for detecting and quantifying nucleic acids |
EP3830302B1 (en) | 2018-08-01 | 2022-10-05 | Gen-Probe Incorporated | Compositions and methods for detecting nucleic acids of epstein-barr virus |
JP2021532808A (en) | 2018-08-08 | 2021-12-02 | ジェン−プローブ・インコーポレーテッド | Compositions, Methods, and Kits for Detecting MYCOPLASMA GENITALIUM |
AU2019326462A1 (en) | 2018-08-21 | 2021-03-25 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus |
CA3108906A1 (en) | 2018-08-24 | 2020-02-27 | Gen-Probe Incorporated | Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis |
WO2020069085A2 (en) | 2018-09-27 | 2020-04-02 | Gen-Probe Incorporated | Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid |
JP7432610B2 (en) | 2018-10-01 | 2024-02-16 | ジェン-プローブ・インコーポレーテッド | Compositions and methods for amplifying or detecting varicella zoster virus |
WO2020086546A1 (en) | 2018-10-22 | 2020-04-30 | Gen-Probe Incorporated | Compositions and methods for amplifying, detecting or quantifying human polyomavirus bk virus |
TW202030333A (en) | 2018-12-20 | 2020-08-16 | 美商簡 探針公司 | Compositions and methods for detecting plasmodium species nucleic acid |
WO2020142347A2 (en) | 2018-12-31 | 2020-07-09 | Gen-Probe Incorporated | Systems and methods for filling multi-well cartridges with solid reagents |
AU2020210753A1 (en) | 2019-01-25 | 2021-09-02 | Gen-Probe Incorporated | Detection of drug-resistant mycoplasma genitalium |
US20220098647A1 (en) | 2019-03-22 | 2022-03-31 | Gen-Probe Incorporated | Compositions and Methods for Detecting Group A Streptococcus |
CA3176699A1 (en) | 2019-05-03 | 2020-11-12 | Gen-Probe Incorporated | Receptacle transport system for an analytical system |
CN114096683A (en) | 2019-07-03 | 2022-02-25 | 简·探针公司 | Oligonucleotides for determining the presence of Trichomonas vaginalis in a sample |
US20220333162A1 (en) | 2019-09-05 | 2022-10-20 | Gen-Probe Incorporated | Detection of chlamydia trachomatis nucleic acid variants |
US20220396786A1 (en) | 2019-11-14 | 2022-12-15 | Gen-Probe Incorporated | Compositions and Methods for Capturing Target Nucleic Acids |
JP2023516683A (en) | 2020-03-04 | 2023-04-20 | ジェン-プローブ・インコーポレーテッド | Compositions and methods for detecting SARS-CoV-2 nucleic acids |
WO2021224873A1 (en) | 2020-05-07 | 2021-11-11 | Grifols Diagnostic Solutions Inc. | Methods and compositions for detecting sars-cov-2 nucleic acid |
JP2023534457A (en) | 2020-07-17 | 2023-08-09 | ジェン-プローブ・インコーポレーテッド | Detection of macrolide-resistant Mycoplasma genitalium |
US20230393163A1 (en) | 2020-10-21 | 2023-12-07 | Gen-Probe Incorporated | Fluid container management system |
WO2022164796A1 (en) | 2021-01-26 | 2022-08-04 | California Institute Of Technology | Allosteric conditional guide rnas for cell-selective regulation of crispr/cas |
JP2024510996A (en) | 2021-03-15 | 2024-03-12 | ジェン-プローブ・インコーポレーテッド | Compositions and methods for biological sample processing |
CA3218222A1 (en) | 2021-05-14 | 2022-11-17 | Gen-Probe Incorporated | Compositions and methods for detecting human adenovirus nucleic acid |
AU2022304654A1 (en) | 2021-07-01 | 2023-12-14 | Gen-Probe Incorporated | Enzyme formulations and reaction mixtures for nucleic acid amplification |
WO2023010008A1 (en) | 2021-07-27 | 2023-02-02 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal pathogens |
WO2023021330A1 (en) | 2021-08-16 | 2023-02-23 | University Of Oslo | Compositions and methods for determining a treatment course of action |
WO2023135485A1 (en) | 2022-01-13 | 2023-07-20 | Oslo Universitetssykehus Hf | Prostate cancer markers and uses thereof |
WO2023175434A1 (en) | 2022-03-15 | 2023-09-21 | Diagenode S.A. | Detection of methylation status of a dna sample |
WO2023248185A1 (en) | 2022-06-24 | 2023-12-28 | Mobidiag Oy | Compact detection system |
WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
WO2024062208A1 (en) | 2022-09-20 | 2024-03-28 | Cost-Bry Pty Ltd (trading as BiomeBank) | Compositions and methods for reducing endogenous sulphide in inflammatory bowel diseases |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0566751A1 (en) * | 1992-03-23 | 1993-10-27 | F. Hoffmann-La Roche Ag | DNA detection method |
EP0601889A2 (en) * | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nucleic acid probes |
WO1997023647A1 (en) * | 1995-12-22 | 1997-07-03 | Behringwerke Aktiengesellschaft | Homogeneous amplification and detection of nucleic acids |
WO1998002582A2 (en) * | 1996-07-16 | 1998-01-22 | Gen-Probe Incorporated | Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m? |
US5723591A (en) * | 1994-11-16 | 1998-03-03 | Perkin-Elmer Corporation | Self-quenching fluorescence probe |
WO1999022018A2 (en) * | 1997-10-27 | 1999-05-06 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4174384A (en) | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4261968A (en) | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
CA1190838A (en) | 1981-07-17 | 1985-07-23 | Cavit Akin | Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer |
US4766064A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay employing polyether and diagnostic kit |
US4766062A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
US5268266A (en) | 1984-05-07 | 1993-12-07 | Genetics Institute, Inc. | Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences |
US4629689A (en) | 1984-08-29 | 1986-12-16 | Allied Corporation | Binding assay with amplified read-out and gas-phase detection |
US4820630A (en) | 1984-11-23 | 1989-04-11 | Digene Diagnostics, Incorporated | Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels |
US4767699A (en) | 1985-05-02 | 1988-08-30 | Allied Corporation | Diagnostic reagent, kit and method employing polynucleotide displacement, separation, enzymatic cleavage and adenosine phosphate detection |
US4735897A (en) | 1985-05-02 | 1988-04-05 | Allied Corporation | Method and kit for detecting polyriboadenosine segments and messenger RNA |
US4822733A (en) | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
US4795701A (en) | 1985-07-17 | 1989-01-03 | Allied Corporation | Homogeneous polynucleotide displacement assay method kit and reagent complex |
US4725536A (en) | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
US4725537A (en) | 1985-09-19 | 1988-02-16 | Allied Corporation | Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage |
US4752566A (en) | 1985-12-17 | 1988-06-21 | Genetics Institute, Inc. | Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide |
US4818680A (en) | 1985-12-18 | 1989-04-04 | Mary Collins | Method and kit involving displacement and rehybridization of labeled polynucleotide |
CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
US4996143A (en) * | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
DE3785591T2 (en) | 1986-01-10 | 1993-09-02 | Amoco Corp | COMPETITIVE HOMOGENEOUS TEST. |
US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
CA2008096A1 (en) | 1989-01-19 | 1990-07-19 | Samuel Rose | Nucleic acid amplification using single primer |
CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
US5439793A (en) | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
US5237515A (en) * | 1991-04-10 | 1993-08-17 | University Of Utah Research Foundation | Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes |
NZ255028A (en) | 1992-07-02 | 1997-03-24 | Hybridon Inc | Antisense oligonucleotides resistant to nucleolytic degradation |
US5445933A (en) * | 1992-09-15 | 1995-08-29 | Boehringer Mannheim Corporation | Strand displacement assay and complex useful therefor |
US6482655B1 (en) | 1993-07-23 | 2002-11-19 | University Of Utah Research Foundation | Immunoassay procedure utilizing fluorogenic tracer antigens |
US5437793A (en) * | 1993-06-08 | 1995-08-01 | Mansfield & Alper, Inc. | Coagulant for oil glyceride/isobutyl methacrylate composition and method of use |
US6576419B1 (en) * | 1993-07-23 | 2003-06-10 | University Of Utah Research Foundation | Assay procedure using fluorogenic tracers |
US5514546A (en) | 1993-09-01 | 1996-05-07 | Research Corporation Technologies, Inc. | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
DK1921169T3 (en) | 1993-11-12 | 2012-06-04 | Phri Properties Inc | Hybridization probes for nucleic acid detection, universal stem cells, methods and kits |
US5491063A (en) * | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
ATE196322T1 (en) | 1995-05-05 | 2000-09-15 | Perkin Elmer Corp | METHODS AND REAGENTS FOR COMBINING PCR AMPLIFICATION WITH A HYBRIDIZATION ASSAY |
US5731148A (en) | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
WO1998010096A1 (en) | 1996-04-12 | 1998-03-12 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
JP3898228B2 (en) | 1996-04-12 | 2007-03-28 | ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク | Detection probes, kits and assays |
US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
US6110676A (en) * | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
US5846726A (en) | 1997-05-13 | 1998-12-08 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
US5928869A (en) | 1997-05-30 | 1999-07-27 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
EP1009852A2 (en) * | 1997-09-04 | 2000-06-21 | Bayer Corporation | Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof |
AU762728B2 (en) | 1998-07-02 | 2003-07-03 | Gen-Probe Incorporated | Molecular torches |
AU2001249386A1 (en) * | 2000-03-22 | 2001-10-03 | Quantum Dot Corporation | Methods of using semiconductor nanocrystals in bead-based nucleic acid assays |
-
1999
- 1999-07-01 AU AU48575/99A patent/AU762728B2/en not_active Expired
- 1999-07-01 JP JP2000558240A patent/JP4646404B2/en not_active Expired - Fee Related
- 1999-07-01 DE DE69941333T patent/DE69941333D1/en not_active Expired - Lifetime
- 1999-07-01 AT AT99932220T patent/ATE440963T1/en not_active IP Right Cessation
- 1999-07-01 ES ES99932220T patent/ES2330812T3/en not_active Expired - Lifetime
- 1999-07-01 WO PCT/US1999/015098 patent/WO2000001850A2/en active IP Right Grant
- 1999-07-01 EP EP99932220A patent/EP1092047B1/en not_active Expired - Lifetime
- 1999-07-01 CA CA2333253A patent/CA2333253C/en not_active Expired - Lifetime
- 1999-07-01 US US09/346,551 patent/US6361945B1/en not_active Expired - Lifetime
-
2001
- 2001-10-31 US US10/001,344 patent/US6534274B2/en not_active Expired - Lifetime
-
2003
- 2003-01-27 US US10/352,355 patent/US6849412B2/en not_active Expired - Lifetime
- 2003-01-27 US US10/352,331 patent/US6835542B2/en not_active Expired - Lifetime
-
2005
- 2005-01-27 US US11/044,090 patent/US7252947B2/en not_active Expired - Fee Related
- 2005-01-27 US US11/044,098 patent/US7250259B2/en not_active Expired - Lifetime
-
2010
- 2010-08-23 JP JP2010186702A patent/JP2010252817A/en not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0566751A1 (en) * | 1992-03-23 | 1993-10-27 | F. Hoffmann-La Roche Ag | DNA detection method |
EP0601889A2 (en) * | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nucleic acid probes |
US5723591A (en) * | 1994-11-16 | 1998-03-03 | Perkin-Elmer Corporation | Self-quenching fluorescence probe |
WO1997023647A1 (en) * | 1995-12-22 | 1997-07-03 | Behringwerke Aktiengesellschaft | Homogeneous amplification and detection of nucleic acids |
WO1998002582A2 (en) * | 1996-07-16 | 1998-01-22 | Gen-Probe Incorporated | Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m? |
WO1999022018A2 (en) * | 1997-10-27 | 1999-05-06 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
Non-Patent Citations (1)
Title |
---|
TYAGI S ET AL: "MOLECULAR BEACONS: PROBES THAT FLUORESCE UPON HYBRIDIZATION" NATURE BIOTECHNOLOGY,US,NATURE PUBLISHING, vol. 100, page 303-308 XP002914999 ISSN: 1087-0156 * |
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Also Published As
Publication number | Publication date |
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DE69941333D1 (en) | 2009-10-08 |
ATE440963T1 (en) | 2009-09-15 |
WO2000001850A3 (en) | 2000-04-06 |
US7250259B2 (en) | 2007-07-31 |
AU762728B2 (en) | 2003-07-03 |
US6835542B2 (en) | 2004-12-28 |
US20020090633A1 (en) | 2002-07-11 |
ES2330812T3 (en) | 2009-12-15 |
US7252947B2 (en) | 2007-08-07 |
EP1092047B1 (en) | 2009-08-26 |
EP1092047A2 (en) | 2001-04-18 |
US6534274B2 (en) | 2003-03-18 |
US6361945B1 (en) | 2002-03-26 |
JP2010252817A (en) | 2010-11-11 |
US20050123988A1 (en) | 2005-06-09 |
US20050130216A1 (en) | 2005-06-16 |
US20030165957A1 (en) | 2003-09-04 |
CA2333253C (en) | 2010-09-07 |
CA2333253A1 (en) | 2000-01-13 |
AU4857599A (en) | 2000-01-24 |
US20030157542A1 (en) | 2003-08-21 |
JP4646404B2 (en) | 2011-03-09 |
US6849412B2 (en) | 2005-02-01 |
JP2002519073A (en) | 2002-07-02 |
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