WO2000004034A3 - Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages - Google Patents

Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages Download PDF

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Publication number
WO2000004034A3
WO2000004034A3 PCT/US1999/015960 US9915960W WO0004034A3 WO 2000004034 A3 WO2000004034 A3 WO 2000004034A3 US 9915960 W US9915960 W US 9915960W WO 0004034 A3 WO0004034 A3 WO 0004034A3
Authority
WO
WIPO (PCT)
Prior art keywords
internucleoside linkages
oligonucleotides
site specific
phosphorothioate internucleoside
chiral phosphorothioate
Prior art date
Application number
PCT/US1999/015960
Other languages
French (fr)
Other versions
WO2000004034A2 (en
Inventor
Phillip Dan Cook
Muthiah Manoharan
Original Assignee
Isis Pharmaceuticals Inc
Phillip Dan Cook
Muthiah Manoharan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Phillip Dan Cook, Muthiah Manoharan filed Critical Isis Pharmaceuticals Inc
Priority to EP99935570A priority Critical patent/EP1097162B1/en
Priority to DE69929524T priority patent/DE69929524D1/en
Priority to AU51022/99A priority patent/AU5102299A/en
Priority to JP2000560140A priority patent/JP2002520420A/en
Publication of WO2000004034A2 publication Critical patent/WO2000004034A2/en
Publication of WO2000004034A3 publication Critical patent/WO2000004034A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Abstract

Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5', and the 3'-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.
PCT/US1999/015960 1998-07-14 1999-07-14 Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages WO2000004034A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99935570A EP1097162B1 (en) 1998-07-14 1999-07-14 Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages
DE69929524T DE69929524D1 (en) 1998-07-14 1999-07-14 OLIGONUCLEOTIDES WITH SPECIFIC CHIRALS FOR BINDING TAPES PHOSPHOROTHIOATINOLUCLEOSIDE BINDINGS
AU51022/99A AU5102299A (en) 1998-07-14 1999-07-14 Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages
JP2000560140A JP2002520420A (en) 1998-07-14 1999-07-14 Oligonucleotides with site-specific chiral phosphorothioate internucleoside linkages

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/115,027 US6242589B1 (en) 1998-07-14 1998-07-14 Phosphorothioate oligonucleotides having modified internucleoside linkages
US09/115,027 1998-07-14

Publications (2)

Publication Number Publication Date
WO2000004034A2 WO2000004034A2 (en) 2000-01-27
WO2000004034A3 true WO2000004034A3 (en) 2000-06-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015960 WO2000004034A2 (en) 1998-07-14 1999-07-14 Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages

Country Status (7)

Country Link
US (3) US6242589B1 (en)
EP (1) EP1097162B1 (en)
JP (1) JP2002520420A (en)
AT (1) ATE316094T1 (en)
AU (1) AU5102299A (en)
DE (1) DE69929524D1 (en)
WO (1) WO2000004034A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
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US9394333B2 (en) 2008-12-02 2016-07-19 Wave Life Sciences Japan Method for the synthesis of phosphorus atom modified nucleic acids

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